tao1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by...
TRANSCRIPT
![Page 1: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/1.jpg)
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes
by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas Levin, Joanna Clark, and Viji M. Draviam
Open BiologyVolume 4(6):130108
June 4, 2014
©2014 by The Royal Society
![Page 2: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/2.jpg)
TAO1-depleted cells display chromosome congression defects.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 3: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/3.jpg)
Rescue of TAO1 depletion-induced chromosome congression defects.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 4: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/4.jpg)
TAO1 is required to maintain dynamic microtubules during mitosis.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 5: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/5.jpg)
TAO1-depleted cells display mis-segregating lagging chromosomes.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 6: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/6.jpg)
Taxol or MPS1 inhibitor treatments in TAO1-depleted cells.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 7: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/7.jpg)
Correcting erroneous kinetochore–microtubule attachments requires TAO1.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society
![Page 8: TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas](https://reader030.vdocument.in/reader030/viewer/2022032702/56649cac5503460f9496ed84/html5/thumbnails/8.jpg)
Model of TAO1 depletion-induced mis-segregation arising from defective microtubule stability.
Roshan L. Shrestha et al. Open Biol. 2014;4:130108
©2014 by The Royal Society