TASHKENT MEDICAL ACADEMY Department of Bioorganic and Biological Chemistry

Bioorganic chemistry I COURSE

SUBJECT : Alkaloids and Vitamins

LECTURE №18

LECTURER : PROFESSOR A.D.DZHURAEV

PURPOSE OF LECTURES:

Form of knowledge of the principlesclassification and structure

important properties of alkaloids andvitamins as the chemical basis of

for further orientationmedicinal

alkaloid nature and vitamins

The questions of: 1. Alkaloids

1.1. Alkaloids of pyridine and piperidine1.2. Quinoline alkaloids group1.3. Phenanthrene alkaloids - isoquinoline1.4. Alkaloids of purine1.5. Tropane alkaloids group1.6. Isoquinoline alkaloids group1.7. Indole alkaloids group1.8. Alkaloids of Phenylethylamine

The questions of2. Vitamins

2.1. Water-soluble vitamins2.1.1. Vitamin B1 (thiamine).2.1.2. Vitamin B2 (riboflavin).2.1.3. Vitamin B6 (adermin, pyridoxine).2.1.4. Vitamin B12 (antianemik, cyanocobalamin).2.1.5. Foul acid.2.1.6. Vitamin C.

2.2. vitamin-like substance2.2.1. Para-aminobenzoic acid.2.2.2. Vitamin B15 (pangamic acid).2.2.3. Inositol.2.2.4. Lipoic acid.

Classification alkaloids

1. GROUP pyridine and piperidine 2. GROUP quinoline 3. GROUP phenanthrene - isoquinoline

4. GROUP Purina

5. GROUP tropane

6. GROUP isoquinoline

7. GROUP indole

Alkaloids pyrrolidine derivatives, pyridine, piperidine

gigrin nicotineconiine

tropaneanabasine

piperidinehalkasi

pyrrolidinehalkasi

Tropane derivatives

cocaine atropine

Piperidine derivatives

piperinelobeline

Quinoline derivatives

quinine morphine heroin

Isoquinoline derivatives

papaverinecodeine

CLASSIFICATION OF VITAMINSI. Water-soluble vitamins

1. Vitamin B1 (thiamine).2. Vitamin B2 (riboflavin).3. Vitamin B6 (adermin, pyridoxine).4. Vitamin B12 (antianemik, cyanocobalamin).5. Foul acid.6. Vitamin C.

II. Fat-soluble vitamins

1 Vitamin A2. vitamin D3. vitamin E4. vitamin K5. vitamin F

III. vitamin-like substance

1. P-aminobenzyl acid.2. Vitamin B15 (Pang acid).3. Inositol.4. Linden acid.

VITAMINS

HCL salt of Vitamin B1 or Thiamin

Vitamin B2 or riboflavin

piridoksol pyridoxal pyridoxamine

Vitamin В6

Folic acid

folic acid

ASCORBIC ACID

tautomerism

vitamin С Keto acid GulonL - sorbose

vitamin-like substance

H2N COOH

p-aminobenzyl acid.

vitamin В15 (pangamic acid)

Inosite

OH

OH

OH

OH

HO

HO

lipoic acid

lipoicacid

dihydrolipoicacid