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TCIASustainmentandScalability–PlatformsforQuantitativeImagingInformaticsinPrecisionMedicine
11/3/2017
FredPrior,PhDUniversityofArkansasforMedicalSciences
JoelSaltz,MD,PhDStonyBrookUniversity
Ashish Sharma,PhDEmoryUniversity
Overview• PrecisionMedicinerequirestheabilitytoclassifypatientsintospecializedcohortsthatdifferintheir
susceptibilitytodisease,inthebiologyand/orprognosisofthediseasestheydevelop,orintheirresponsetotherapy.Identifyingquantitativeimagingphenotypesacrossscalethroughtheuseofradiomic/pathomicanalysesisanevolvingapproachtocohortidentificationandtoimprovingourunderstandingofcancerbiology.Theseanalytictechniquesrequirelargecollectionsofwell-curateddataforalgorithmtestingandvalidation.
• Since2011theCancerImagingArchive(TCIA)hasencouragedandsupportedcancer-relatedopenscienceresearchbyacquiring,curating,hostingandmanagingcollectionsofmulti-modalinformation.ToremainrelevanttoitscurrentresearchcommunityTCIAmustundergocontinuousimprovementandexpansionofitcapabilitiesguidedbytheresearchcommunity.
• TheTCIAusercommunityhasidentifiedfourcriticalareasforimprovement:– expandedresourcesforintegrativeImage-Omics studies,– enhancedcapacitytoacquirehighqualitydatacollections,– resourcestosupportvalidationstudiesandResearchReproducibility,– increasedcommunityengagement.
SpecificAims• Aim1:DeployexpandedresourcesforIntegrativeImage-Omics Studies.– expandedcapabilitiesindatadriveninformationintegration,semanticquerycapabilityandfeaturemanagement
• Aim2:Increasecapacitytoacquirehighqualitydatacollections.– extendandautomatecurationprocessestoincreaseTCIA’scollectionsandaddnewtypesofdatabasedonprioritiesestablishedbyourResearchAdvisoryCommittee
– consolidatetheTCIAsoftwarestackintoasetofeasilydeployableentitiestoreduceTCIA’slong-terminternaloperationalcosts
• Aim3:Enhanceresourcestosupportvalidationstudiesandresearchreproducibility.– deployasetoftoolsandcapabilitiestodirectlysupportITCRimaginggrandchallenges
• AIM4:EmphasizeCommunityEngagement,CollaborationandDissemination.– ResearchAdvisoryCommitteewillbecreatedtoprovidedirectcommunityguidanceonTCIAenhancementandcollectionpriorities.
ResearchAdvisoryCommittee• ThisgroupofexpertswillprovidedirectcommunityguidanceonTCIAenhancementsandcollectionpriorities.
• Dr.TJFitzgeraldhasagreedtochairtheRACandthefollowingseniorscientistshaveagreedtoparticipate:– Dr.MichaelMcNitt-Gray(UCLA),– Dr.Jayashree Kalpathy-Cramer(Harvard),– Dr.Metin Gurcan (OSU),– Dr.SamuelAchilefu (WashingtonUniversity),– Dr.HugoAerts (Harvard).– NCIwillalsoprovidealiaisontotheRAC.
ImageDerivedFeatures
• Annotations,Segmentations,RadiomicsfeaturesetsarebeingsubmittedtoTCIA
• Currentmanagementmechanismsonlysupportdiscoveryanddownload
• Growingneedforafeatureontologyanda“featurebase”
EvolvingtheRepositoryArchitecture
TCIADistributedObjectStore
UAMS
AWS
Emory
Stoneybrook
IndexingandSearchEngines AnalyticsEngines
GUIandVisualization(Clients)
DataAccessEngines
OtherRepositories
InSummary
ThesustainmentofTCIAandresearchcommunitydirectedexpansionofitscapabilitieswillensurethisvaluableresourcecontinuestopromoteresearchreproducibilityanddatareuseincancerprecisionmedicalresearch.