tdms no. 20307 - 04 p09: non-neoplastic …...tdmse version: 2.4.2.1_003 pwg approval date: none...
TRANSCRIPT
![Page 1: TDMS No. 20307 - 04 P09: NON-NEOPLASTIC …...TDMSE Version: 2.4.2.1_003 PWG Approval Date: NONE TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested:](https://reader033.vdocument.in/reader033/viewer/2022042419/5f367b7b010a6a3b64168de7/html5/thumbnails/1.jpg)
F1_M3C Number: C20307
Lock Date: 12/28/2009
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.4.2.1_003
PWG Approval Date: NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
![Page 2: TDMS No. 20307 - 04 P09: NON-NEOPLASTIC …...TDMSE Version: 2.4.2.1_003 PWG Approval Date: NONE TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested:](https://reader033.vdocument.in/reader033/viewer/2022042419/5f367b7b010a6a3b64168de7/html5/thumbnails/2.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
ALIMENTARY SYSTEM
Esophagus I + + + + + + + + + 9
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + M + + + + + + + + 9Cyst X 1
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Follicle, Degeneration 2 1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + M + + + + 9
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M + M M + M + M M + 4
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 3.0
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Tongue + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10Cyst X X 2
Pituitary Gland + + + + + + + I + + 9
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M + + + M + M M M M 4
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
Skeletal Muscle + 1
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retina, Dysplasia 2 1 2.0
Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 2 1 2 1.5
URINARY SYSTEM
Kidney + + + + + + + + + + 10Inflammation, Chronic 1 1 1.0
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25%ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 4 1.5
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25%ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
Hyperkeratosis 1 1 2 1.0Hyperplasia 2 2 2 1 2 2 1 1 2 9 1.7Inflammation, Chronic Active 1 2 1 2 2 1 1 7 1.4Hair Follicle, Hyperplasia 1 1 1 3 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 1 1 2 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 2 1 2 1.5Control, Inflammation, Chronic Active 2 1 2 1.5
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
Control, Hair Follicle, Hyperplasia 2 1 2.0
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 3 2.0Hyperkeratosis 1 1 2 2 1 5 1.4Hyperplasia 2 2 3 2 1 2 1 3 1 2 10 1.9Inflammation, Chronic Active 1 2 2 2 2 2 1 2 1 2 10 1.7Hair Follicle, Hyperplasia 2 1 2 1.5
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + I + + + + + 9Centrilobular, Hypertrophy 1 2 1 3 1.3
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + I + + + + + 9
INTEGUMENTARY SYSTEM
Skin + + + + I + + + + + 9Control, Fibrosis 1 1 1.0Control, Hyperplasia 1 1 1 1 4 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Control, Inflammation, Chronic Active 1 1 2 1 4 1.3
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 2 2 2 2 8 1.8Hyperkeratosis 1 1 2 1 2 5 1.4Hyperplasia 1 1 1 2 2 2 2 2 3 9 1.8Inflammation, Chronic Active 1 1 1 2 2 2 2 2 2 9 1.7Epidermis, Inflammation, Suppurative 1 1 1.0Hair Follicle, Hyperplasia 1 3 3 3 2.3
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Fibrosis 2 1 2 1.5Control, Hyperkeratosis 2 2 2 2.0Control, Hyperplasia 3 2 1 3 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
Control, Inflammation, Chronic Active 2 2 2 2.0Control, Epidermis, Inflammation, Suppurative 2 1 2.0Control, Hair Follicle, Hyperplasia 2 1 2.0
Skin, Site Of Application + + + + + + + I + + 9Fibrosis 1 2 2 2 2 1 2 1 8 1.6Hyperkeratosis 1 1 1 2 1 2 1 2 8 1.4Hyperplasia 2 3 2 3 2 3 2 2 2 9 2.3Inflammation, Chronic Active 1 1 2 2 2 2 2 2 1 9 1.7Epidermis, Inflammation, Suppurative 2 1 2.0Hair Follicle, Hyperplasia 1 1 2 1 1 1 1 7 1.1
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
ALIMENTARY SYSTEM
Esophagus + I + + + + + + + + 9
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 2 2 4 2.0
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Tongue + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + M + + 9
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M M + M + M + M + M 4
Skin + + + + + + + + + + 10Control, Fibrosis 1 2 1 2 1 5 1.4Control, Hyperkeratosis 2 2 1 1 2 5 1.6Control, Hyperplasia 2 3 2 2 2 3 2 2 8 2.3Control, Inflammation, Neutrophil 1 1 1.0Control, Inflammation, Chronic Active 2 2 2 1 2 2 2 1 8 1.8Control, Epidermis, Inflammation, Suppurative 1 1 1 1 4 1.0Control, Hair Follicle, Hyperplasia 2 1 2 2 1 5 1.6
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 2 2 2 2 2 2 2 10 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Hyperkeratosis 2 2 2 2 2 2 1 1 2 1 10 1.7Hyperplasia 2 3 3 3 2 3 3 3 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 1 1 1 5 1.0Hair Follicle, Hyperplasia 2 2 1 1 2 2 2 2 8 1.8
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 1 1 1.0Inflammation, Chronic 2 1 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
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DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
*** END OF MALE DATA ***
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + M + 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + M + 9
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
Vagina + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + M + + + 9
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + M + + + + + + 9
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + M M + + M + + + 7
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland M + M M + + + + + M 6
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
Vagina + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10Ulcer 4 1 4.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 1.0
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 1 1 4 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Control, Inflammation, Chronic Active 1 1 1 2 4 1.3
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1.5Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 3 2 2 2 2 2 2 2 2 2 10 2.1Inflammation, Chronic Active 2 2 2 1 2 2 2 1 2 2 10 1.8Hair Follicle, Hyperplasia 1 2 1 3 1.3
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Fibrosis 1 1 2 3 1.3
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
Control, Hyperkeratosis 1 1 1.0Control, Hyperplasia 2 1 2 3 1.7Control, Inflammation, Chronic Active 2 1 1 2 4 1.5
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 1 2 2 1 1 2 2 2 1 2 10 1.6Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 1 2 2 1 2 2 2 2 1 3 10 1.8Inflammation, Chronic Active 1 2 2 2 1 2 2 2 1 2 10 1.7Epidermis, Inflammation, Suppurative 1 1 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 2 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
Control, Inflammation, Chronic Active 2 1 2 1.5Control, Hair Follicle, Hyperplasia 1 1 1.0
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 1 2 2 2 1 2 1 10 1.7Hyperkeratosis 2 2 3 2 1 2 1 2 1 1 10 1.7Hyperplasia 2 2 2 2 2 2 2 2 2 2 10 2.0Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 2 1 1 4 1.3Hair Follicle, Hyperplasia 2 3 3 3 4 2.8
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart I + + + + + + + + + 9
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen I + + I + + + + + + 8
Thymus I I + + + + + + + + 8
INTEGUMENTARY SYSTEM
Skin I + + I + + + + + + 8Control, Hyperplasia 1 1 1 3 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Control, Inflammation, Chronic Active 1 2 1 3 1.3
Skin, Site Of Application I I I I + + + + + + 6Fibrosis 1 1 1 2 4 1.3Hyperkeratosis 2 1 2 2 2 2 6 1.8Hyperplasia 3 3 2 2 2 2 6 2.3Inflammation, Chronic Active 2 2 2 2 2 2 6 2.0Ulcer 2 1 2.0Epidermis, Inflammation, Suppurative 1 1 1 2 4 1.3Hair Follicle, Hyperplasia 3 1 2 3 2.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + M + + M + 8Cyst X 1
Pituitary Gland + + + + + I + + + + 9
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Vagina + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node + 1
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10Atrophy 2 2 2 2.0
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Control, Fibrosis 2 2 1 1 1 2 6 1.5Control, Hyperkeratosis 2 1 2 2 2 2 3 7 2.0Control, Hyperplasia 3 1 2 3 2 1 2 1 3 3 10 2.1Control, Inflammation, Chronic Active 2 1 2 2 2 2 2 2 8 1.9Control, Ulcer 2 1 2.0Control, Epidermis, Inflammation, Suppurative 1 1 2 2 2 2 1 2 8 1.6Control, Hair Follicle, Hyperplasia 1 2 3 3 2.0
Skin, Site Of Application + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Fibrosis 3 2 2 2 1 2 2 2 2 9 2.0Hyperkeratosis 3 2 1 3 2 1 2 2 2 3 10 2.1Hyperplasia 3 3 3 3 3 3 2 2 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 2 1 2 1 1 7 1.3Hair Follicle, Hyperplasia 1 1 2 2 1 3 2 2 3 3 10 2.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0
Harderian Gland + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
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DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
*** END OF REPORT ***
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43