Technical features of Ploom Tech,JTI’s novel tobacco vapor device

Ian Jones, PhDVice President, Reduced-Risk ProductsJT International

Inhalable tobacco products in

which the tobacco is not

combusted during intended

use

Tobacco Vapor Products (TVPs)

Non-combusted tobacco

products for inhalation

(NCTPIs)

What is Tobacco Vapor ?

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Tobacco Vapor Category:existing technologies

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Direct heatingIndirect heating

(Air)

Ambient

(no heating)

Indirect heating

(Liquid)

Heats or Burns or Combusts?..

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Indirect heating Direct & indirect heating Combustion

Co

0 100 200 400 500 600 700 800300

Heated sticks

CigarettesCharcoal heated

Heated pods

Hybrid products

Human bodytemperature

Domestic oven Pizza oven The middle of a fireplace

Ploom Tech hybrid device

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TECH-CAP

• Specially blended

granulated tobacco

CARTRIDGE

• Contains non-nicotine containing liquid to create vapor

BATTERYTOBACCO VAPOR

• No smoke, no smoke smell, no ash

How Ploom Tech works

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Aerosol picks up tobacco

flavour and nicotine from

tobacco particles

Aerosol with tobacco

flavour/nicotine

from tobacco

CARTRIDGETECH-CAP

HeaterPlain Aerosol Liquid

°C

100

200

400

500

600

700

800

300

0

30°C

Scientific data: Vapor chemistry

Approximately 99% reduction in levels of measured

constituents compared to cigarette smoke

Source:Chemical and in vitro toxicological analysis of a vapor from a novel tobacco vapor device and capsuleTakahashi, Y; Kanemaru, Y; Fukushima ,T; Eguchi K and Miller-Holt, JPresented at EuroTox 2016

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Scientific data: In vitro toxicology

Micronucleus assay

AMES assay Neutral red assay

◆：3R4F ■：NTV

Source:Chemical and in vitro toxicological analysis of a vapor from a novel tobacco vapor device and capsuleTakahashi, Y; Kanemaru, Y; Fukushima ,T; Eguchi K and Miller-Holt, JPresented at EuroTox 2016

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© Copyright JTI

Scientific data:In vitro cellular responses (human bronchial epithelial cells)

Strong potential to be a reduced-risk product

Source:Comparative effects of cigarette smoke and novel tobacco product vapor on in vitro cellular responses in human bronchial epithelial cellsMunakata, S; Ishimori, K; Takanami, Y; Ishikawa, S; Ito, SPresented at Society of Toxicology Annual Meeting 2017

Evidence of correlation between tobacco temperature and biological activity

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Lower cell toxicity than directly-heated tobacco

vapor (HnB product) or cigarette smoke

C

o

0100200400500600700800 300

Cigarette

Competitive directly

heated product in Japan

Evidence of correlation between tobacco temperature and vapor chemistry

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C

o

0100200400500600700800 300

90%

93%

95%

99%Stated reductions in measured harmful and potentially harmful vapor constituents (HPHCs) compared to cigarette smoke

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Summary

Ploom Tech:

• A tobacco vapor product

• Hybrid technology

• Indirectly heats tobacco to 30 °C

• No burning of tobacco, no smoke, smoke smell or ash

• 99% reduction in measured HPHCs in vapor compared to smoke

• Significantly reduced in vitro biological responses compared to

smoke

Has strong potential as a reduced-risk product

Thank you!

Any questions?

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