Temistocle Despina Luciana

Short background The Candida gender is represented by dimorphic-like fungi

can shift from yeast to pseudomycelial state, depending on the environmental conditions of the host.

exception - Candida glabrata which is an anamorphic species.

Candida and especially Candida albicans colonizes the oral mucosa and becomes invasive when the immune system most of the oral-maxillofacial conditions are associated with Candida.

Purpose The qualitative and quantitative assessment of yeast colonization of the

oral cavity in patients with oro-maxillo-facial (OMF) conditions the establishment of an association between the different contributing

factors and colonization.

Material and methodsThe study was conducted on a sample of 70 patients

hospitalized in OMF clinic.Samples were collected by rinsing the mouth with sterile saline. Historical data were also collected.

Material and methodsThe samples were analysed at the Microbiology

Laboratory of UMF Tg MuresCulture:

Sabouraud agar medium

Material and methodsIdentification:

Chromogenic medium

Identification:For Candida non-albicansBiomerieux ID32C

Material and methodsAntifungigram

fluconazole and voriconazole following the CLSI standards.

Results

ResultsIdentified yeast species

Resultsgender vs. Candida carriage

p = 0,075

Resultssmoking habits vs. Candida carriage

P = 0,74 P = 0,0053OR = 2,34 (1,428 - 3,843)

Resultsoral hygiene vs. Candida carriage

P = 0,496

Resultsantibiotic use vs. Candida carriage

P = 0,798

AMP, CRO, DA

Resultsantifungal resistance in Candida spp.

ConclusionsColonization with yeasts of the oral cavity is present in about half of

the patients with OMF conditions Probably due to

classical predisposing factors due to chronic oral pathology

The most significant predisposing factor is smokingOral hygiene diminishes Candida colonization although not

significantly.The testing of Candida spp. to fluconazole showed an increased

resistance, probably due to oral antifungal therapy C. non-albicans kept their sensibility to voriconazole