temporal lobe lesion

8/9/2019 Temporal Lobe Lesion

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TEMPORAL LOBE LESION

Kluver Bucy Syndrome



Cerebrum

1. Largest pa rt of the br ainLearning and Senses

2 h emisp h eres- Right and LeftConnected by the Co rpus C allo sumRigh t side controls- left sideLeft side controls r ight s ide of body

Four sect ions - LOBES1. Fron tal Lobe 2 . P arietal Lobe3. Occipital Lobe 4.Temp o ral Lobe



K lüver-Bucy sy n dr o me is a beh aviora l disorder th a t occurswhen both the r ight and leftmed ia l tem pora l lobes of the

brain ma lfunct ion . The amygd a lahas been a pa rt icularly imp lica tedbrain reg ion in the pa thogenes isof th is syndrome .



Klüver-Bucy syndrome

A Disorder produced by b ila ter a l

temp

ora

l lobectomy,character ized by p lacidity, soc ia llyinapp ropriate sexu a l act ivity,

com pulsive ora lity, a decre asedability to recogn ize peo p le, andmemory def icits .



Sympt o msThe list of sym p toms d iffers somewh a t by source . Gener a lly

included are the follow ing:Docility. Character ized by exh ibit ing d im inishedfear responses or re act ing with unusu a lly lowaggress ion . This has a lso been termed"p lacidity" or "tameness" .Diet ary changes . Character ized by ea t inginapp ropriate objects and/or overe a t ing (e .g.

bulim ia).Hyperor a lity. This is descr ibed as "an ora ltendency, or com pulsion to ex am ine objects bymouth" .



Hypersexu a lity. Character ized by a

he ightened sex dr ive or a tendency to seeksexua l stimula t ion from unusu a l orinapp ropriate objects .Visua l agnos ia . Character ized by an inability

to recogn ize f am iliar objects or peo ple.Hypermet amor phos is, character ized by "anirres ist ible impulse to not ice and re act toeveryth ing w ith in sight" .Lack of emot iona l response, d im inishedemot iona l affect . Memory loss .



It is rare for hum ans to m anifest a ll of theident if ied sym p toms of the syndrome;three or more are requ ired fordiagnos is.Among hum ans, the most commonsymp toms include p lacidity, hy peror a lity anddiet ary changes . They m ay a lso present w ith an

inability to recogn ize objects or inability torecogn ize f aces or other memory d isorders .



Klüver-Bucy syndromeIn an a ttem p t to reduce aggress ion in monkeys,

Klüver &Bucy (1939) inflicted l arge b ila ter a l lesions of the infer ior tem pora l lobe of wild monkeys housed in

a labor a tory These lesions a ffected high level v isua l assoc iat ioncort ica l areas, amygd a la , hipp ocampus



Klüver-Bucy syndromeSymptoms of Klüver-Bucy syndrome

PSYCHIC BLINDNESS did not app rec iate thesign if icance ofwh a t they were look ing a t

HYPERMETAMORPHOSIS compulsively app roacha ll items they encounter

ORAL TENDENCIES they put everyth ing theyfound in the irmouth

CHANGE IN EMOTIONAL BEHAVIOR

bec ame t ame,emot iona llybland, SHOWED LITTLE FEAR of hum ans or n a tur a lly fear-invok ing st imul i (i.e . snakes)CHANGES IN SEXUAL BEHAVIOR

ind iscrim inantly sexu a l



Klüver-Bucy follow-ups We now know th a t many of these ch anges are de pendent

upon (b ila ter a l) amygd a la lesionsIn subsequent work, les ions of the amygd a la in pa rt icularmade monkeys fe arless of e .g. hum ans or sn akes, andaffect ively fla t, t ame

Also disrupted soc ial inter act ion (changes in sexu a l behavior most prob ably due to d amageto the pyriform cortex, not rel a ted to amygd a la)



W h at is K lüver-Bucy Sy n dr o me?

Klüver-Bucy syndrome is a rare beh aviora l impai rmentth a t is assoc iated w ith damage to both of the anter iortem pora l lobes of the br ain. It causes ind ividua ls toput objects in the ir mouths and eng age ininapp ropriate sexu a l behavior. Other sym ptoms m ayinclude visua l agnos ia (inability to v isua lly recogn izeobjects ), loss of norm a l fear and anger res ponses,memory loss, d istr act ibility, se izures, and dement ia . The d isorder m ay be assoc iated w ith her pesence pha lit is and tr aum a , which can result in braindamage .



As rega rds h is visua l funct ions, the pa t ientseemed un able to recogn ize a wideva riety of common objects . He exam ined e achobject placed before h im asthough see ing it for the f irst t ime, ex plored itrepet it ively and seemed un awareof its s ign if icance . he seemed un able todist ingu ish between relev ant andirrelev ant objects and act ions .Behaviora l pa tterns were d ist inctly abnorm a l.

He exh ibited a fla t affect, and,a lthough or igina lly restless, ult ima telybec ame rem a rkably placid. He app eared

ind ifferent to peo p le or situa t ions Onoccasion he bec ame f acet ious,sm iling inapp ropriately and m im icking thegestures and act ions of others .



All objects th a t he could f ind were p laced inhis mouth and sucked orchewed he ingested v irtu a lly everyth ingwith in reach, includ ing the p last icwrapp er from bre ad, cleaning pa stes, ink, dogfood and feces .

The pa t ient s sexua l behavior was a pa rt icularsource of concern wh ile in hos pita l.Although v igorously heterosexu a l prior to h isillness, he w as observed inhos pita l to make advances tow ard other m a lepa t ients by strok ing the ir legs

and invit ing fella t io by gesture; a t t imes, hea ttem pted to k iss them .Marlowe, Mancall, & Thomas, 1975, pp. 55-56

temporal lobe lesion

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