International Partnership for International Partnership for MicrobicidesMicrobicides

International Partnership for International Partnership for MicrobicidesMicrobicides

Tessa Mattholie, European Liaison Officer, Tessa Mattholie, European Liaison Officer, BrusselsBrussels

IPM MissionIPM MissionIPM MissionIPM Mission

IPM’s mission is to prevent HIV transmission by accelerating the development and access of safe and effective microbicides for use by women in developing countries.

Pathway of Microbicide Pathway of Microbicide DevelopmentDevelopment

1. Assess and fundacross the microbicide

portfolio

4. Optimize clinical trialcapacity

2. Help develop the“next generation”of microbicides

3. Provide commoncapabilities or

supports for the field

5. Coordinate effortto ensure worldwide

access

DiscoveryBasicresearch

Pre-clinical

Clinicaltrials

Launch &Access

Multiple mechanisms/targets/products

Formulation capacityIn vitro and in vivo modelsRegulatoryManufacturing

IPM InfrastructureIPM InfrastructureIPM InfrastructureIPM Infrastructure

4 areas of initial focus were on the gaps/bottlenecks in microbicide development pathway:

Screening/activity testing Formulation NHP testing Clinical trials material manufacturing

IPM Clinical TrialsIPM Clinical TrialsIPM Clinical TrialsIPM Clinical Trials

Vaginal ring Phase I trial of TMC120 completed in Belgium

TMC120 Gel Phase I/II trial in Africa(Developing clinical trial sites)

Male tolerance of TMC120

IPM’s Approach to AccessIPM’s Approach to AccessIPM’s Approach to AccessIPM’s Approach to Access

Ensuring availability requires: Appropriate regulatory approval and licensing

infrastructure Manufacturing capability and sufficient capacity Logistics and delivery networks in-country

Ensuring adoption requires: End-user awareness about the product and its benefits Effective pricing and financing mechanisms to ensure

affordability Supportive social and policy environment (and the

research to generate this)

European advocacy activitiesEuropean advocacy activitiesEuropean advocacy activitiesEuropean advocacy activities

Aims: Increase political commitment for

microbicides Increase funding for R&D through

national research institutions and PPPs Advance policy environment for

development of, and acess to, microbicides

Current Donors to the IPMCurrent Donors to the IPMCurrent Donors to the IPMCurrent Donors to the IPM

Canada Denmark EC Gates Foundation Ireland Netherlands Norway

Rockefeller Foundation

Sweden UK UN US World Bank

How to Contact IPM?How to Contact IPM?How to Contact IPM?How to Contact IPM?

Visit our website at

www.ipm-microbicides.org

Email Tessa Mattholie at:

tmattholie@ipm-microbicide.org