Testing for von Willebrand Disease

Factor VIII:C

vWF:Ag No further testing

vWF:RCo <10% vWF:CBA <10% Multimerics: loss of all

Type III

Normal (?)Less then 10% or absent

Decreased

Multimerics Analysis

Relative decrease or loss of HWM vWF:CBA

Normal

Probable Type I

Decreased

Probable Type II

vWF:RCo Decreased

Normal

vWF:CBA

Normal Decreased

Multimerics: smeary pattern

Multimerics: loss of HWM

Likely Type IIM Likely Type IIA or IIB

Probable Type I

Supplemental Data Figure 1.