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8TH SANTORINI Conference SYSTEMS MEDICINE, PERSONALISED HEALTH & THERAPY3-5 October 2016Thira-Santorini / Greece

Nomikos Conference Centerwww.santoriniconference.org

PRELIMINARY PROGRAM

GOLD SPONSORS

ANSARI Marc (Geneva, Switzerland)

AUFFRAY Charles (Lyon, France)

BAROUKI Robert (Paris, France)

BÜHLMANN Roland P. (Schönenbuch, Switzerland)

DAGHER Georges (Paris, France)

DEDOUSSIS George (Athens, Greece)

DELOUKAS Panos (Cambridge, United Kingdom)

FITZGERALD Peter (Crumlin, Co-Antrim, United Kingdom)

FROGUEL Philippe (Lille, France)

INGELMAN-SUNDBERG Magnus (Stockholm, Sweden)

JACOBS Peter (Gent, Belgium)

LAMONT John (Co-Antrim, United Kingdom)

LLERENA Adrian (Badajoz, Spain)

MANOLOPOULOS Vangelis G. (Alexandroupolis, Greece)

MÄRZ Winfried (Mannheim, Germany)

MEIER-ABT Peter (Basel, Switzerland)

MEYER Urs A. (Basel, Switzerland)

NOYER-WEIDNER Mario (Berlin, Germany)

ROSES Allen (Durham, USA)

SIEST Gérard (Nancy, France) †SIEST Sofia (Nancy, France)

VAN SCHAIK Ron (Rotterdam, The Netherlands)

UMR INSERM U1122IGE-PCVInteractionsGène-Environnementen PhysiopathologieCardio-Vasculaire,Nancy, France

SCIENTIFIC COMMITTEE

ORGANIZING COMMITTEEALDASORO ARGUIÑANO Alex-AnderCHATELIN JérômeHIEGEL BrigitteKLEIN MarcMASSON ChristinePETRELIS AlexandrosRANCIER MarcSIEST Gérard †SIEST SofiaSTATHOPOULOU MariaVERMION CatherineWERYHA Georges Richard XIE Ting

Under the auspices of:

BRONZE SPONSORS

SILVER SPONSORS

Congress VenueNomikos Conference CenterPetros M. Nomikos A.E.Santorini, GreeceTel.: +30210 7241516Email: info@thera-conferences.grcom

Contact OrganizationCom&Co, Etienne Jarry15, Bd Grawitz - 13016 Marseille, FranceTel.: +33 (0)4 91 09 70 53Fax: +33 (0) 4 96 15 33 08Email: ejarry@comnco.com

PRELIMINARY PROGRAM AT A GLANCE

ACKNOWLEDGEMENTS

INFORMATION

Dear colleagues, Dear friends,

We have simulating conference program wich will be comple-ted by the last arrived abstract.

It will be organized in close collaboration with ESPT. After the most successful 2014 conference ever with the highest number of participants we are planning again with the scientific com-mittee a 3 days meeting.

Starting the first day with Systems Medicine we have 2 specific clinical prospective sessions.

A second day devoted to the phenotypes importance in the studies of physiological variations chronic diseases and under the environment effects, particularly nutrition.

The last day, sessions will be constructed around personal therapy with the use of the new genomic data. The recent introduction of new drugs and development of biological pathways also are interesting topics.

We are now waiting the abstracts for posters presentations until July 20th.

SANTORINI is an inspiring island for thinking about the future of Personalised Health and Individual Therapy.

We hope to see you there.

Sofia Siest

8TH SANTORINI Conference

WELCOME LETTER

Online registration: www.santoriniconference.org

REGISTRATION

OPENING RECEPTION

Coffee break & first poster visitCoffee break & poster visit

Coffee break & last poster visit

Coffee break & poster visit

Lunch break

Poster visit

Lunch break & poster visit Lunch break

SESSION I FROM SYSTEMS BIOLOGY TO SYSTEMS MEDICINE

SESSION V OMICS STUDIES OF HUMAN

PHENOTYPES AND ENVIRONMENT

SESSION VII PHARMACOGENOMICS AND PERSONALISED / STRATIFIED THERAPY

SESSION II SYSTEMS PHARMACOGENOMICS

AND MECHANISMS OF DRUG ACTION

SESSION VI NUTRITION AND METABOLIC HEALTH

SESSION VIII GENOMIC BIOMARKERS

AND MANAGEMENT OF METABOLIC AND INFLAMMATORY DISEASES

SESSION IX NEW BIOMARKERS

AND COMPANION DIAGNOSTICS

ROUND TABLE

VGF CONSORTIUM MEETING

ESPT GENERAL ASSEMBLY

SESSION III CELLULAR TARGETS

IN ONCO-HEMATOLOGYSELECTED ORAL PRESENTATION

SESSION IV GENOMICS AND PROTEOMICS OF ALZHEIMER’S DISEASE

GALA DINNER Special keynote addresses in honor of Gérard Siest

POSTER AWARDS CEREMONY

MONDAY OCTOBER 3RD TUESDAY OCTOBER 4TH WEDNESDAY OCTOBER 5TH

Diagnostics

SPONSORS

Coffee break

H2020 MSCA-RISE-2015 (MAST4HEALTH

PROJECT)

ESPT WORKING GROUPS

SATE

LLIT

E M

EETI

NGS

08:00 REGISTRATION

08:30 SESSION I

FROM SYSTEMS BIOLOGY TO SYSTEMS MEDICINE

Chairs:CharlesAuffray,Lyon, France / SofiaSiest,Nancy, France

08:30 • From the 1st to the 8th Colloquium - SofiaSiest, Nancy, France

09:10 • The strategic vision and implementation plan of the newly formed European Association of Systems Medicine - CharlesAuffray,Lyon, France

09:30 • Mechanistic bioprofiles and pharmacophenomics for precision medicine of heart failure - FaiezZannad,Nancy, France

10:00 • Epigenetic signatures of brain aging - AndreasPapassotiropoulos,Basel, Switzerland

10:30 Coffee break and first poster visit

11:00 SESSION II

SYSTEMS PHARMACOGENOMICS AND MECHANISMS OF DRUG ACTION

Chairs:PeterMeier-Abt, Bern, Switzerland / UrsMeyer,Basel, Switzerland

11:00 • Metabolomics and its role in precision medicine: From patient to drug - JohnRyals,Raleigh, USA

11:30 • Prediction of combination therapy based on perturbation modeling of the immune system signaling network in patients with multiple sclerosis - PabloVilloslada,Barcelona, Spain

12:00 • Genomic precision to be achieved in the use of VEGF- inhibitors in cancer patients - FedericoInnocenti,Chapel Hill, USA

12:30 Poster visit

13:00 Lunch break

14:00 SESSION III

CELLULAR TARGETS IN ONCO-HEMATOLOGY Chairs:MarcAnsari,Geneva, Switzerland /

MajaKrajinovic,Montreal, Canada 14:00 • Stem cells and enzymatic target - MarcAnsari,

Geneva, Switzerland 14:30 • Tumor immunity and immunotherapy: past, present,

future - Pierre-YvesDietrich,Geneva, Switzerland 15:00 • The myeloma targets - AurorePerrot,Nancy, France 15:30 • Leukemia pharmacogenomics - MajaKrajinovic,

Montreal, Canada

16:00 Coffee break and poster visit

16:30 SESSION IV

GENOMICS AND PROTEOMICS OF ALZHEIMER’S DISEASE

Chairs:AndreasPapassotiropoulos,Basel, Switzerland / AllenRoses,Chapel Hill, USA

16:30 • TOMM40-APOE haplotypes and Alzheimer’s disease in multiple ethnic groups - AllenRoses,Chapel Hill, USA

17:00 • Functional analysis of the APOE/TOMM40 locus implicates a complex regulatory structure - LynnBekris,Cleveland, USA

17:30 • Proteomics, identification of new small molecules and prediction of Alzheimer‘s disease - ErichWanker,Berlin, Germany

18:00 • The case of genetic determination of leukocyte telomere length in childhood - EllenUmlof,Vienna, Austria

19:00 OPENING RECEPTION Suites of the Gods on the Caldera

08:30 SESSION V

OMICS STUDIES OF HUMAN PHENOTYPES AND ENVIRONMENT

Chairs:GeorgesDedoussis,Athens, Greece / BaishenPan,Shanghai, China

08:30 • Biobanks, omics, nutritional habits and cardiovascular phenotypes - PanosDeloukas,London, United Kingdom

09:00 • Update on the exposome in Europe and in The States - RobertBarouki,Paris, France

09:30 • Non alcoholic fatty liver disease (NAFLD): interaction between phenotype and environment - AmaliaGastaldelli,Pisa, Italy

09:50 • The human plasma-metabolome: reference values in 800 healthy volunteers; impact of cholesterol, gender and age - LaurentBecquemont,Paris, France

10:10 Coffee break and poster visit

10:30 SESSION VI

NUTRITION AND METABOLIC HEALTH Chairs:RolandP.Bühlmann,Basel, Switzerland /

MarioNoyer-Weidner,Berlin, Germany 10:30 • Gene-nutrient interaction data stemmed

from nutritional interventions. The paradigm of the MAST4HEALTH EU program - GeorgesDedoussis,Athens, Greece

11:00 • The gut microbiome and metabolic health - PilarFrancino,Valencia, Spain

11:30 • Xenohormetic nutrient signals that modulate aging and healthspan: a complex regulatory network for nutrigenomics research - GiovanniScapagnini,Molise, Italy

12:00 ESPT GENERAL ASSEMBLY 13:30 Lunch break and poster visit

14:30 SELECTED ORAL PRESENTATION 14:30 • Clinical Development of Tanibirumab and its next

generation bispecific antibodies for cancer treatment - Jin-SanYoo,Daejeon, South Korea

14:45 • Unbiased mass-spectrometry-based metabolomics profiling in over 1,000 patients reveals specific abnormalities in biochemical pathways in patients with atherosclerosis, as defined by cardiovascular CT-based precision phenotyping in the multi-center GLOBAL Clinical study - SzilardVoros,Atlanta, USA

15:00 • Single nucleotide polymorphisms in dopaminergic pathways genes are associated with bruxism - GonzaloHOportoV,Temuco, Chile

15:15 • The “antioxidogram”: a biomarker of clinical interest for personalized medicine in blood diseases - OlivierHerault,Tours, France

15:30 Coffee break

16:00 SATELLITE MEETINGS (simultaneous sessions) 16:00-17:30 ESPT WORKING GROUPS ON: Pediatric individualised treatment

in oncology hematology Moderator:MarcAnsari,Geneva, Switzerland

Curriculae and education for pharmacogenomics and personalized medicine

Moderator:JanjaMarc,Ljubljana, Slovenia

Endiobiotic and drug interactions Moderator:AdrianLlerena,Badajoz, Spain

Transporter of drugs and metabolites Moderator:IngolfCascorbi, Kiel, Germany 16:00 • Drug transporters in cancer resistance -

IngolfCascorbi, Kiel, Germany 16:20 • Pharmacogenetics of drug transporters: clinically

relevance - MauricioSimmaco,Roma, Italy 16:40 • General discussion 17:25 • Final remarks - IngolfCascorbi, Kiel, Germany

16:00-18:00 H2020 MSCA-RISE-2015 (MAST4HEALTH PROJECT) Practical issues in NAFLD/NASH

diagnosis and management Moderator:MilicaMedic-Stojanoska,

Oxford, United Kingdom 16:00 • An interventional study with a natural product

to implement safety and efficacy - AndrianaKaliora,Athens, Greece

16:30 • General discussion 17:55 • Final remarks - GeorgeDedoussis,Athens, Greece

21:00 GALA DINNER – Pyrgos restaurant Special keynote addresses in honor of Gérard Siest A lifetime work dedicated to the promotion

of personalised medicine and the visionary man behind the Santorini Conferences. Withtheparticipationof:

• The Director of the Research Unit, UMR INSERM U1122; IGE-PCV - SofiaSiest, Nancy, France

• The President of the University of Lorraine - PierreMutzenhardt, Nancy, France

• The President of the European Society of Pharmacogenomics and Personalised Therapy - RonH.VanSchaik, Rotterdam, The Netherlands

• The President of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) - On behalf of the President, Maurizio Ferrari: TomrisOzben, Antalya, Turkey

POSTER AWARDS CEREMONY Awards granted by the University of Lorraine

and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).

08:30 SESSION VII

PHARMACOGENOMICS AND PERSONALISED / STRATIFIED THERAPY

Chairs:Pierre-YvesDietrich,Geneva, Switzerland / RonVanSchaik,Rotterdam, The Netherlands

08:30 • A novel predictive tool for 5-Fluorouracil toxicity and efficacy - MaurizioSimmaco, Roma, Italy

09:00 • Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility - Andrew Lukowiak,San Diego, USA

09:30 • The use of pharmacogenomic methodologies in the pharmacovigilance evaluation of medicinal products - MichaelMarschler,Mann-heim, Germany

10:00 • High throughput ADME PGx genotyping for clinical trial stratification - RobinEverts,San Diego, USA

10:30 • GSTA1 genetic variants: a missing key factor in Busulfan first dose prediction models in conditio-ning before hematopoietic stem cell transplant in children - TiagoNava,Montreal, Canada

10:45 Coffee break and last poster visit

11:15 SESSION VIII

GENOMIC BIOMARKERS AND MANAGEMENT OF METABOLIC AND INFLAMMATORY DISEASES

Chairs:FedericoInnocenti,Chapel Hill, USA / WinfriedMärz,Augsburg, Germany

11:15 • Genomic stratification and diabetes - PhilippeFroguel,Lille, France

11:45 • Causality versus predictive ability in personalised medicine: C-Reactive Protein - BehroozZ.Alizadeh,Gröningen, The Netherlands

12:15 • Interplay between epigenetic mechanisms in rheumatic disorders - SteffenGay,Zurich, Switzerland

12:45 • Contribution of an integrative multi-omic approach in the metabolic syndrome prediction: a nested case-control study - BlandineComte, Saint-Genès-Champanelle, France

13:00 • The association of ATP binding cassette gene B1 (ABCB1) C3435T polymorphism with apixaban peak concentration in patients with acute cardioembolic stroke and atrial fibrillation - AlexanderKryukov,Moscow, Russia

13:15 Lunch break

14:30 SESSION IX

NEW BIOMARKERS AND COMPANION DIAGNOSTICS

Chairs:LynnBekris,Washington, USA / PanosDeloukas,London, United Kingdom

14:30 • Cell-Free DNA: the search of prognostic biomarkers in prostate - TomrisÖzben,Antalya, Turkey

15:00 • PCSK9 and Pharmacogenomics - WinfriedMärz,Augsburg, Germany

15:30 • Osteoporosis in the age of biotherapies with anti-sclerostin - GeorgesWeryha,Nancy, France

16:00 • OneOmics in the cloud: integrating multi-omics data for quantitative system biology - Jean-BaptisteVincendet,Paris, France

16:30 ROUND TABLE The future of personalised medicine, systems

medicine and systems pharmacology: how to translate the big data for the clinicians and personalised therapy

Discussionleaders:CharlesAuffray,Lyon, France / SofiaSiest,Nancy, France

Panel discussion • DenisHorgan,EAPM, Brussels, Belgium • AdrianLlerena,Badajoz, Spain • GeorgesDagher, Paris, France - Next generation

biobanking • MarisaPapaluca,EMA, Belgium • CaterinaCinti, Foresight, NRCI, Italy - Theranostics

for P4-Medicine • MagnusIngelmannSundberg,Stockholm, Sweden

(Skype) • MunirPirmohamed,Liverpool, United Kingdom (Skype)

17:30 VEGF CONSORTIUM MEETING Moderator:SofiaSiest,Nancy, France

18:30 End of the conference

MONDAY OCTOBER 3RD TUESDAY OCTOBER 4TH WEDNESDAY OCTOBER 5TH REGISTRATION FORM

PRELIMINARY PROGRAM8TH SANTORINI Conference

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INDIVIDUAL REGISTRATION FEES (VAT 20% INCL.)

TO BE RETURNED BY:POST Com&Co - 15, Bd Grawitz - 13016 Marseille, FranceFAX +33 (0)4 96 15 33 08EMAIL ejarry@comnco.com

ONLINE REGISTRATION: www.santoriniconference.org

8TH SANTORINI Conference SYSTEMS MEDICINE, PERSONALISED HEALTH & THERAPY

3-5 October 2016 Thira-Santorini / Greece

Before August 1st After August 1st

Full registration 650€ 800€

ESPT Members 600€ 800€

ESPT Associate Members 625€ 800€

Student registration 300€ 400€

ESPT Members 275€ 400€

Accompanying 300€ 350€

TOTAL DUE ........................................................................... € vat incl.

The full and Student registration fees include: • Entrance to plenary lectures, symposia,

workshops, posters sessions and exhibition• Delegate’s bag (incl. abstracts book)• Certificate of attendance• Coffee and tea service during intermissions• Lunches of October 2016, 3rd, 4th and 5th 2016 • Welcome Reception (October 2016, 3rd)• Gala dinner (October 2016, 4th)

The Accompanying registration fee includes: • Posters sessions and exhibition• Coffee and tea service during intermissions• Lunches of October 2016, 3rd, 4th and 5th 2016 • Welcome Reception (October 2016, 3rd)• Gala dinner (October 2016, 4th)

PAYMENTq By credit card: Visa, Mastercard (no other card) On protected payment Paybox online form, directly on the website www.comnco.com. Please indicate your name + SANTORINI 2016 in the part: “Additional details”.

q By check enclosed (please make check in Euro payable in France to Com&Co)

q By bank transfert Beneficiary :Com&Co Bank: Banque Chaix 41- 43, Bd Peytral - 13006 Marseille IBAN: FR76 1017 8000 2600 2626 3880 380 BIC : CCBPFRPPCHX

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CALL FOR ABSTRACTSSubmissionfororalpresentationisnowclosed butyoucanstillsubmitabstractsforposterpresentation...

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