the 46th annual meeting of the japanese society …the 46th annual meeting of the japanese society...

30
The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2 100002 1-B-W4-9-O/P Presentation: 7min, Discussion: 2min Toshihiko Kobayashi Department of Molecular Immunology &amp; Inflammation, Research Institute, NCGM Regulatory role of an oligopeptide transporter SLC15A3 during the systemic inflammation Dec. 12 (Tue.), 2017 14:55-16:15 Room B Endogenous innate immunity and inflammation-2 Osamu Takeuchi Sachiko Takamura (Akashi) 100007 1-H-W16-3-O/P Presentation: 6min, Discussion: 2min Takashi Izawa Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan Crosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone homeostasis Dec. 12 (Tue.), 2017 14:55-16:15 Room H Cytokines and chemokines-2 Takayuki Yoshimoto Takashi Kobayashi 100009 1-I-W18-7-O/P Presentation: 7min, Discussion: 3min Kota Kokubo Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan <strong>Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells.</strong> Dec. 12 (Tue.), 2017 14:55-16:15 Room I Helper T cells Masakatsu YAMASHITA Motoko Y. KIMURA 100010 1-I-W17-1-O/P Presentation: 7min, Discussion: 3min Yuki Hitomi Department of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo Japan Identification of the disease causal variants in human primary biliary cholangitis (PBC) susceptibility gene loci <em>NFKB1/MANBA</em> Dec. 12 (Tue.), 2017 13:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio 100011 1-I-W17-7-P Poster Presentation Tomonori Hayashi Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan <strong>Relationship between T-cell Frequencies before Vaccination, Cytokine Levels, and Influenza Vaccine Response</strong> Dec. 12 (Tue.), 2017 Odd Number / 16:30-17:30, Even Number / 17:30-18:30 Exhibition Hall Human Immunology Koji Yasutomo Keishi Fujio 100012 2-B-W20-2-O/P Presentation: 7min, Discussion: 3min Takeshi Machida Department of Immunology, Fukushima Medical University, Fukushima, Japan <strong>Significant role for splenic marginal zone B cells in anti-dsDNA autoantibody production in lupus-prone mice with an MRL background</strong> Dec. 13 (Wed.), 2017 14:25-15:45 Room B Systemic autoimmune disease (1) Hitoshi Kohsaka Shinsuke Yasuda 100013 1-D-W7-11-P Poster Presentation Motomi Yamazaki Department of Gastroenterology, Nihon University School of Medicine Effects of H1N1 influenza virus infection on maternal and fetal in pregnant mouse Dec. 12 (Tue.), 2017 Odd Number / 16:30-17:30, Even Number / 17:30-18:30 Exhibition Hall Virus infection-1 Taro Kawai Mitsutoshi Yoneyama 100014 1-C-W5-9-P Poster Presentation Yusei Miyazaki Hokkaido Medical Center, Sapporo, Japan <strong>Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis</strong> Dec. 12 (Tue.), 2017 Odd Number / 16:30-17:30, Even Number / 17:30-18:30 Exhibition Hall Tissue-specific immune diseases I Mitsuru Matsumoto Daisuke Kamimura 100015 3-I-W42-5-O/P Presentation: 7min, Discussion: 3min Honglian Tong Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells Dec. 14 (Thu.), 2017 12:50-14:10 Room I T cell-2 : T cell signaling Satoshi Matsuda Tadashi Yokosuka 100016 1-H-W16-10-P Poster Presentation Munehiro Yamaguchi Department of Internal Medicine, Division of Allergology and Respiratory Medicine, School of Medicine, Showa University, Tokyo, Japan IL-34 induces lung fibrosis via M2 macrophages differentiation in mouse lung injured model Dec. 12 (Tue.), 2017 Odd Number / 16:30-17:30, Even Number / 17:30-18:30 Exhibition Hall Cytokines and chemokines-2 Takayuki Yoshimoto Takashi Kobayashi 100017 2-H-W24-8-P Poster Presentation Risa Nakamura Department of Parasitology, NEKKEN, Nagasaki University, Nagasaki, Japan Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice Dec. 13 (Wed.), 2017 16:00-17:00 Exhibition Hall Immune response to parasite infections Yoichi Maekawa Masahiro Yamamoto 100018 2-I-W25-1-O/P Presentation: 7min, Discussion: 3min Tomofumi Uto Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan Critical role of plasmacytoid dendritic cells in the induction of oral tolerance for the control of allergic sensitization Dec. 13 (Wed.), 2017 14:25-15:45 Room I Dendritic cells and Macrophages-1: Organ- specific Immune Tolerance Satoshi Ishido Kenichi Asano 100019 2-F-W22-14-O/P Presentation: 8min, Discussion: 3min Osamu Kaminuma Center for Life Science Research, University of Yamanashi Establishment of non-transgenic monoclonal T cell receptor-expressing mice Dec. 13 (Wed.), 2017 14:25-15:45 Room F T cell-1: T cell development and repertoire selection Taishin Akiyama Takeshi Nitta 100020 2-H-W24-13-P Poster Presentation Motoko Morimoto School of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai City, Miyagi, Japan Antibiotic-induced changes in the intestinal microbiota affect the host resistance against helminths in murine small intestine Dec. 13 (Wed.), 2017 16:00-17:00 Exhibition Hall Immune response to parasite infections Yoichi Maekawa Masahiro Yamamoto 100021 3-H-W40-4-P Poster Presentation Kensuke Yanashima Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan <strong>Synthetic host defense peptide IDR-1018 activates various functions of human mast cells</strong> Dec. 14 (Thu.), 2017 Odd Number / 16:00-17:00, Even Number / 17:00-18:00 Exhibition Hall Granulocyte & Mast cells Atsuhito Nakao Yosuke Kurashima 100022 3-I-W43-13-O/P Presentation: 7min, Discussion: 3min Junpei Suzuki Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan <strong>The tumor suppressor menin epigenetically regulates CD8 T cell senescence via the modulation of glutamine metabolism</strong> Dec. 14 (Thu.), 2017 14:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu 100023 3-G-W38-2-O/P Presentation: 7min, Discussion: 4min Maiko Okumura 1st Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama Production of Ro52/TRIM21 autoantibodies that react to PEP08 epitope in Ro52 clinically relate to the morbidity and severity of interstitial lung disease in connective tissue diseases. Dec. 14 (Thu.), 2017 12:50-14:10 Room G Systemic autoimmune disease (2) Yoshiya Tanaka Masayuki Nishide 100024 1-D-W8-5-O/P Presentation: 6min, Discussion: 2.5min Eiji SHINYA Nippon Medical School, Tokyo, Japan Hematopoietic cell kinase (Hck) augmented the interaction between HIV-1 Nef and SERINC5, which might promote HIV-1 infection by excluding SERINC5 from virion incorporation in immature dendritic cells Dec. 12 (Tue.), 2017 14:55-16:15 Room D Virus infection-2 Takashi Fujita Hiroyuki Oshiumi 100025 2-I-W25-8-P Poster Presentation Yasuyuki Negishi Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan Adoptive transfer of innate immune cells induce murine fetal loss Dec. 13 (Wed.), 2017 16:00-17:00 Exhibition Hall Dendritic cells and Macrophages-1: Organ- specific Immune Tolerance Satoshi Ishido Kenichi Asano 100026 1-G-W13-1-P Poster Presentation Ikuo Nobuhisa Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos Dec. 12 (Tue.), 2017 Odd Number / 16:30-17:30, Even Number / 17:30-18:30 Exhibition Hall Hematopoiesis and immune environments Takashi Nagasawa Hitoshi Takizawa 100027 3-C-W30-5-P Poster Presentation Hirofumi Miyazaki Department of Organ Anatomy, Graduate School of Medicine, Tohoku University FABP7 is involved in the M2 polarization of macrophages via mitochondrial fatty-acid oxidation Dec. 14 (Thu.), 2017 Odd Number / 16:00-17:00, Even Number / 17:00-18:00 Exhibition Hall Dendritic cells and Macrophages-2: Development and Recognition Tomohiko Tamura Masafumi Nakayama 100028 3-C-W31-17-P Poster Presentation Aya Ushio Department of Oral Molecular Pathology, Graduate school of Biomedical Sciences, Tokushima University, Tokushima, Japan CCL22-producing resident macrophages enhances autoimmune lesions in a mouse model of Sj&ouml;gren&rsquo;s syndrome Dec. 14 (Thu.), 2017 Odd Number / 16:00-17:00, Even Number / 17:00-18:00 Exhibition Hall Dendritic cells and Macrophages-3: Inflammatory Responses Tsuneyasu Kaisho Rikinari Hanayama 1 / 30

Upload: others

Post on 29-May-2020

3 views

Category:

Documents


0 download

TRANSCRIPT

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100002 1-B-W4-9-O/PPresentation: 7min,

Discussion: 2min

Toshihiko

KobayashiDepartment of Molecular Immunology &amp;

Inflammation, Research Institute, NCGMRegulatory role of an oligopeptide transporter SLC15A3 during the systemic inflammation

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100007 1-H-W16-3-O/PPresentation: 6min,

Discussion: 2minTakashi Izawa

Department of Orthodontics and Dentofacial

Orthopedics, Tokushima University Graduate

School of Biomedical Sciences, Tokushima,

Japan

Crosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone

homeostasis

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100009 1-I-W18-7-O/PPresentation: 7min,

Discussion: 3minKota Kokubo

Department of Immunology, Graduate School of

Medicine, Chiba University, Chiba, Japan

<strong>Menin controls the memory Th2 cell function by maintaining the epigenetic integrity

of Th2 cells.</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100010 1-I-W17-1-O/PPresentation: 7min,

Discussion: 3minYuki Hitomi

Department of Human Genetics, Graduate

School of Medicine, the University of Tokyo,

Tokyo Japan

Identification of the disease causal variants in human primary biliary cholangitis (PBC)

susceptibility gene loci <em>NFKB1/MANBA</em>

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100011 1-I-W17-7-P Poster Presentation Tomonori HayashiDepartment of Molecular Biosciences, Radiation

Effects Research Foundation, Hiroshima, Japan

<strong>Relationship between T-cell Frequencies before Vaccination, Cytokine Levels, and

Influenza Vaccine Response</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100012 2-B-W20-2-O/PPresentation: 7min,

Discussion: 3minTakeshi Machida

Department of Immunology, Fukushima Medical

University, Fukushima, Japan

<strong>Significant role for splenic marginal zone B cells in anti-dsDNA autoantibody

production in lupus-prone mice with an MRL background</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100013 1-D-W7-11-P Poster Presentation Motomi YamazakiDepartment of Gastroenterology, Nihon

University School of MedicineEffects of H1N1 influenza virus infection on maternal and fetal in pregnant mouse

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100014 1-C-W5-9-P Poster Presentation Yusei Miyazaki Hokkaido Medical Center, Sapporo, Japan<strong>Fingolimod induces BAFF and expands circulating transitional B cells without

activating memory B cells and plasma cells in multiple sclerosis</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100015 3-I-W42-5-O/PPresentation: 7min,

Discussion: 3minHonglian Tong

Division of Molecular and Cellular

Immunoscience, Department of Biomolecular

Sciences, Faculty of Medicine, Saga University,

Saga, Japan

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of

antigen-stimulated T cells

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100016 1-H-W16-10-P Poster PresentationMunehiro

Yamaguchi

Department of Internal Medicine, Division of

Allergology and Respiratory Medicine, School of

Medicine, Showa University, Tokyo, Japan

IL-34 induces lung fibrosis via M2 macrophages differentiation in mouse lung injured modelDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100017 2-H-W24-8-P Poster Presentation Risa NakamuraDepartment of Parasitology, NEKKEN, Nagasaki

University, Nagasaki, JapanType 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100018 2-I-W25-1-O/PPresentation: 7min,

Discussion: 3minTomofumi Uto

Division of Immunology, Department of

Infectious Diseases, Faculty of Medicine,

University of Miyazaki, Miyazaki, Japan

Critical role of plasmacytoid dendritic cells in the induction of oral tolerance for the control of

allergic sensitization

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100019 2-F-W22-14-O/PPresentation: 8min,

Discussion: 3minOsamu Kaminuma

Center for Life Science Research, University of

YamanashiEstablishment of non-transgenic monoclonal T cell receptor-expressing mice

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100020 2-H-W24-13-P Poster Presentation Motoko MorimotoSchool of Food, Agricultural, and Environmental

Sciences, Miyagi University, Sendai City, Miyagi,

Japan

Antibiotic-induced changes in the intestinal microbiota affect the host resistance against

helminths in murine small intestine

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100021 3-H-W40-4-P Poster PresentationKensuke

Yanashima

Atopy (Allergy) Research Center, Juntendo

University Graduate School of Medicine, Tokyo,

Japan

<strong>Synthetic host defense peptide IDR-1018 activates various functions of human

mast cells</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100022 3-I-W43-13-O/PPresentation: 7min,

Discussion: 3minJunpei Suzuki

Department of Hematology, Clinical Immunology

and Infectious Diseases, Ehime University

Graduate School of Medicine, Ehime, Japan

<strong>The tumor suppressor menin epigenetically regulates CD8 T cell senescence via

the modulation of glutamine metabolism</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100023 3-G-W38-2-O/PPresentation: 7min,

Discussion: 4minMaiko Okumura

1st Department of Internal Medicine, Graduate

School of Medicine and Pharmaceutical

Sciences (Medicine), University of Toyama

Production of Ro52/TRIM21 autoantibodies that react to PEP08 epitope in Ro52 clinically

relate to the morbidity and severity of interstitial lung disease in connective tissue diseases.

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100024 1-D-W8-5-O/PPresentation: 6min,

Discussion: 2.5minEiji SHINYA Nippon Medical School, Tokyo, Japan

Hematopoietic cell kinase (Hck) augmented the interaction between HIV-1 Nef and

SERINC5, which might promote HIV-1 infection by excluding SERINC5 from virion

incorporation in immature dendritic cells

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100025 2-I-W25-8-P Poster Presentation Yasuyuki NegishiDepartment of Microbiology and Immunology,

Nippon Medical School, Tokyo, JapanAdoptive transfer of innate immune cells induce murine fetal loss

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100026 1-G-W13-1-P Poster Presentation Ikuo NobuhisaDepartment of Stem Cell Regulation, Medical

Research Institute, Tokyo Medical and Dental

University (TMDU), Tokyo, Japan

Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic

hematopoietic cell cluster formation in midgestation mouse embryos

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100027 3-C-W30-5-P Poster Presentation Hirofumi MiyazakiDepartment of Organ Anatomy, Graduate School

of Medicine, Tohoku University

FABP7 is involved in the M2 polarization of macrophages via mitochondrial fatty-acid

oxidation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100028 3-C-W31-17-P Poster Presentation Aya UshioDepartment of Oral Molecular Pathology,

Graduate school of Biomedical Sciences,

Tokushima University, Tokushima, Japan

CCL22-producing resident macrophages enhances autoimmune lesions in a mouse model

of Sj&ouml;gren&rsquo;s syndrome

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

1 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100029 2-C-W21-10-P Poster Presentation Soki KashimaDepartment of immunology, Institute for Frontier

Life and Medical Sciences, Kyoto University,

Kyoto, Japan

WT1-specific CTLs regenerated from T cell derived iPS cells exert therapeutic effect in

xenograft model of renal cell carcinoma

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100030 3-A-W27-14-O/PPresentation: 10min,

Discussion: 3minHiroki Satooka

Department of Fundamental Biosciences, Shiga

University of Medical Science, Shiga, Japan

The ERM protein moesin regulates CD8<sup>+</sup> regulatory T cell homeostasis and

self-torelance

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100031 1-A-W1-13-P Poster Presentation Chika KanamoriDepartment of Animal medical science, Faculty

of Life science, Kyoto Sangyo University, Kyoto,

Japan

<strong>Effects of Cryptomeria Japonica pollen and cigarette smoke on immune

cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100032 3-D-W32-16-P Poster Presentation Naosuke MorikawaGraduate School of Pharmaceutical Sciences,

Osaka University, Osaka, Japan

<strong>LY341495, an mGluR2/3 antagonist, attenuates the immunosuppressive function

of myeloid-derived suppressor cells and inhibits the melanoma tumor growth.</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100033 3-C-W31-5-O/PPresentation: 8min,

Discussion: 3minTanapat Palaga

Department of Microbiology, Faculty of Science,

Chulalongkorn University, Bangkok, Thailand

Notch Signaling Regulates Macrophages Activation by LPS in the Presence of Immune

Complex

Dec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100034 2-B-W20-1-O/PPresentation: 7min,

Discussion: 3minSumie Hiramatsu

Department of Nephrology, Rheumatology,

Endocrinology and Metabolism, Okayama

University Graduate School of Medicine,

Dentistry and Pharmaceutical Sciences,

Okayama, Japan.

DNA Methylation-dependent regulation of Cathepsin E gene expression by the transcription

factor Kaiso in MRL/lpr mice.

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100035 2-I-W25-7-P Poster Presentation Yo UedaDepartment of Rheumatology and Clinical

immunology, Kobe University Graduate School of

Medicine, Kobe, Japan

<strong>Inhibition of the mTOR Pathway and Glutaminolysis Facilitates the Expansion of

Myeloid-Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG

Mice</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100036 3-G-W39-7-O/PPresentation: 7min,

Discussion: 4minHarumi Shirai

Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

Investigation of pathogenesis of Adult onset Still&rsquo;s disease through lymphocyte

subsets analysis in peripheral blood followed by RNA-sequencing

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100037 1-C-W6-4-O/PPresentation: 7min,

Discussion: 3minKojiro Sato

Department of Rheumatology and Applied

Immunology, Saitama Medical University,

Saitama, Japan

Analysis of the function of Nfatc1 isoforms in the differentiation of osteoclasts and an

attempt to make short-form specific Nfatc1 knockout mice with the CRISPR/Cas9 system

Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100038 3-D-W32-9-O/PPresentation: 7min,

Discussion: 3minTakuto Nosaka

Second Department of Internal Medicine, Faculty

of Medical Sciences, Fukui University, Eiheiji-

machi, Japan

<strong>Alveolar macrophages drive hepatocellular carcinoma lung metastasis in

collaboration with interstitial macrophages</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100039 2-C-W21-11-P Poster Presentation Rong ZhangDivision of Cancer Immunotherapy, Exploratory

Oncology Research &amp; Clinical Trial Center,

National Cancer Center, Kashiwa, Japan

Type 1 IFN-producing myeloid cells influence on host immune system to inhibit tumor

growth

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100040 1-B-W4-1-O/PPresentation: 7min,

Discussion: 2min

Ayako

WakabayashiDepartment of Microbiology and Immunology,

Nippon Medical School, Tokyo, Japan

Enhancement of epithelial cell death, cytoplasmic HMGB1 expression in IECs, and increase

of HMGB1 release by oral CT-stimulation

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100041 1-A-W1-3-O/PPresentation: 7min,

Discussion: 3min

Satoko Tahara-

HanaokaDepartment of Immunology, Faculty of Medicine,

University of Tsukuba, Tsukuba, Japan

Inhibition of house dust mite-induced Th2 responses by Allergin-1 immunoreceptor on

dendritic cells

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100042 1-I-W18-1-O/PPresentation: 7min,

Discussion: 3minSoh Yamazaki

Department of Biochemistry, Toho University

School of MedicineThe AP-1 transcription factor JunB is essential for development of Th17 cells

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100043 3-E-W34-8-O/PPresentation: 7min,

Discussion: 3minTsubasa Okano

Department of Pediatrics and Developmental

Biology, Graduate School of Medical and Dental

Sciences, Tokyo Medical and Dental University

(TMDU), Tokyo, Japan

Maternal B cells, engrafted in patients with X-linked severe combined immunodeficiency (X-

SCID), could undergo class switch recombination without somatic hypermutation and cause

IgG1 gammopathy.

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100044 1-F-W11-3-O/PPresentation: 9min,

Discussion: 2minNaoto Nishii

Department of Molecular Immunology, Graduate

School, Tokyo Medical and Dental University

Systemic administration of low dose TLR7 agonist augments antitumor responses in the

PD-1 checkpoint blockade-resistant and regulatory T cell-dominant murine tumor models

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100045 1-H-W16-11-P Poster Presentation Izumi SasakiDepartment of Immunology, Institute of

Advanced Medicine, Wakayama Medical

University, Wakayama, Japan

Roles of arginine and methionine metabolism in cholera toxin-induced adjuvant effectsDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100046 1-E-W9-17-P Poster Presentation Kazuhiro NegoroDepartment of Immunology, Institute of

Advanced Medicine, Wakayama Medical

University, Wakayama, Japan

An Ets family member, Ets2 is required for Cholera toxin-induced arginase-1 gene

expression

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100047 3-B-W29-4-O/PPresentation: 11min,

Discussion: 2minTakanori So

Department of Microbiology and Immunology,

Tohoku University Graduate School of Medicine,

Sendai, Japan

Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the

TNFR superfamily molecule GITR

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100049 3-I-W42-8-P Poster Presentation Kaoru ToshimaDivision of Glycopathology, Institute of Molecular

Biomembrane and Glycobiology, Tohoku Medical

and Pharmaceutical University, Miyagi, Japan

Sphingomyelin is involved in TCR-induced apoptosis in thymocyte developmentDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100050 2-G-W23-1-O/PPresentation: 10min,

Discussion: 3min

Kazuhiko

Yamamura

Department of Dermatology, Graduate School of

Medical Sciences, Kyushu University, Fukuoka,

Japan

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31

induction

Dec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100051 3-I-W43-9-P Poster Presentation Ryoyo IkebuchiLaboratory of Immunology, Faculty of Pharmacy,

Osaka Ohtani University, Tondabayashi, Osaka,

Japan

Single-cell gene and protein expression analysis revealed functional and migratory

heterogeneity in regulatory T cells of inflamed skin

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

2 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100052 3-F-W36-9-O/PPresentation: 7min,

Discussion: 3min

Masaaki

HASHIGUCHI

Department of Immunology, Dokkyo Medical

University School of Medicine, Mibu, Tochigi,

Japan

Tumor necrosis factor superfamily member (TNFSF) 13, APRIL and TNFSF13B, BAFF

downregulate homeostatic immunoglobulin production in intestines

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100053 1-D-W8-1-O/PPresentation: 6min,

Discussion: 2.5minTakayuki Chikata

Center for AIDS Research, Kumamoto

University, Kumamoto, JapanControl of HIV-1 by an HLA-B*52:01-HLA-C*12:02 protective haplotype

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100054 1-C-W5-10-P Poster Presentation Koji ShinodaDepartment of Neurology, Neurological Institute,

Graduate School of Medical Sciences, Kyushu

University, Fukuoka, Japan

A distinct repertoire of the &gamma;&delta; T cell population is associated with disease

severity of multiple sclerosis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100055 3-D-W33-5-O/PPresentation: 7min,

Discussion: 3minChie Kudo-Saito

Department of Immune Medicine, National

Cancer Center Research Institute, Tokyo, Japan

<strong>Targeting the pathogenic mesenchymal stromal/stem cells prevents immune

exhaustion</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100056 1-A-W2-1-P Poster Presentation Oji NakamuraDepartment of Applied Biological Chemistry,

Tokyo University of Agriculture and Technology,

Tokyo, Japan

Effect of honeybush extracts on the murine model of pollen allergyDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100057 3-B-W28-10-P Poster Presentation Masato KameiDepartment of Immunology, Juntendo University

School of Medicine, Tokyo, JapanMAIT cells exacerbate the disease course of oxazolone colitis.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100058 2-G-W23-2-O/PPresentation: 10min,

Discussion: 3minAkihiko Murata

Division of Immunology, Department of

Molecular and Cellular Biology, School of Life

Science, Faculty of Medicine, Tottori University,

Japan

Local skin memory response in contact dermatitis involves tissue resident memory T cellsDec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100059 3-I-W43-5-O/PPresentation: 7min,

Discussion: 3minAkihiro Shimba

Institute for Frontier Life and Medical Sciences,

Kyoto University, Kyoto, Japan

Glucocorticoids drive diurnal changes in distibution and response of T cells via IL-7 receptor

expression

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100060 3-B-W28-11-O/PPresentation: 11min,

Discussion: 2minGoh Murayama

Department of Immunology, Juntendo University

School of Medicine, Tokyo, JapanRole of mucosal-associated invariant T cells in lupus pathogenesis

Dec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100061 1-H-W15-6-O/PPresentation: 6min,

Discussion: 2minMasaaki Kawano

Department of Allergy and Immunology, Faculty

of Medicine, Saitama Medical University,

Saitama, Japan

<strong>Dopamine fluctuates cytokine secretion in innate and adaptive immune

responses</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100062 2-F-W22-1-O/PPresentation: 8min,

Discussion: 3minYoichi Sutoh

Iwate Tohoku Medical Megabank Organization,

Iwate Medical University, Yahaba, Japan

<strong>Origin of thymic selection inferred from the deviated antigen receptor usage in

lamprey</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100063 1-I-W18-17-P Poster Presentation Shunta KanekoDepartment of Internal Medicine, Faculty of

Medicine, University of Tsukuba, Ibaraki, Japan.

The RORgt-CCR6-CCL20 axis enhances Th17 cells invasion into the synovia of patients in

rheumatoid arthritis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100064 1-A-W2-2-P Poster Presentation Inoue AkikoDepartment of Otorhinolaryngology, Toho

University School of Medicine, Tokyo, JapanStudy of relationship of allergy and chronic rhinosinusitis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100065 2-I-W25-5-O/PPresentation: 7min,

Discussion: 3minSho Sendo

Department of Rheumatology and Clinical

Immunology, Kobe University Graduate School

of Medicine, Kobe, Japan.

<strong>CD11b<sup>+</sup>Gr1<sup>dim</sup> Tolerogenic Dendritic Cell-like Cells

Differentiated from Monocytic-MDSCs Suppress the Progression of Interstitial Lung Disease

in SKG Mice</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100066 1-D-W7-9-O/PPresentation: 6min,

Discussion: 2minTomoko Takahashi

Department of Biological Sciences, Graduate

School of Science, The University of Tokyo

LGP2 upregulates apoptosis-related genes by acting as an RNA silencing modulator during

viral infection

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100067 2-A-W19-17-O/PPresentation: 7min,

Discussion: 3minChiao-Ching Hsu

Laboratory of Immune Regulation, Graduate

School of Medicine, Osaka University, Japan

<strong>Human LYPD8 protein has motility inhibitory functions to pathogenic flagellated

bacteria</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100068 2-B-W20-11-P Poster Presentation Chi LiuDivision of Transplantation Immunology, National

Center for Child Health and Development, Tokyo,

Japan

<strong>Combination of 5-aminolevulinic acid and iron prevents skin fibrosis in murine

sclerodermatous grafts-versus-host disease</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100070 1-B-W3-2-O/PPresentation: 7min,

Discussion: 2min

Sachiko  Akashi-Takamura

Aichi Medical University School of Medicine,

Nagakute, JapanC4b binding protein negatively regulates cell-surface TLRs response

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100071 3-G-W39-2-P Poster Presentation Shizuyo TsujimuraThe First Department of Internal Medicine,

School of Medicine University of Occupational

and Environmental Health, Kitakyushu, Japan

<strong>The Characteristic of the P glycoprotein expression on the B cell subsets in

rheumatoid arthritis</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100072 2-B-W20-14-P Poster Presentation Mareki OhtsujiToin Human Science and Technology Center,

Department of Biomedical Engineering, Toin

University of Yokohama,Kanagawa,Japan

<strong>Inhibitory effect of the blocking of monocyte recruitment from the blood on

spontaneously occurring arthritis </strong><strong>in arthritis-prone Fc&gamma;RIIB-

deficient mice</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100073 2-G-W23-17-P Poster Presentation Kazunobu OKONDepartment of Applied Biological Chemistry,

Tokyo University of Agriculture and TechnologyStudies of the anti-allergic activity of honeybush

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100074 3-I-W43-6-P Poster Presentation Guangwei CuiLaboratory of Immune Regulation, Institute for

Frontier Life and Medical Sciences, Kyoto

University, Kyoto, Japan

Competition between STAT5 and PI3K of the IL-7R modulates T cell and type 2 ILC

development in vivo

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

3 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100075 3-B-W28-2-O/PPresentation: 11min,

Discussion: 2minTsukasa Nabekura

Life Science Center, Tsukuba Advanced

Research Alliance, University of Tsukuba,

Ibaraki, Japan

Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after

cytomegalovirus infection

Dec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100076 3-A-W26-11-P Poster Presentation Cuiying HeDepartment of Immunology and Parasitology,

University of Occupational and Environmental

Health, Kitakyushu, Japan.

<strong>Urban particulate matter 2.5 induced immunosuppression in splenocytes is related

with lipopolysaccharide level on particulate matter 2.5</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100077 1-B-W4-14-P Poster Presentation Takashi MinoInstitute for Frontier Life and Medical Sciences,

Kyoto University

<strong>Regnase-1 regulates inflammatory mRNAs during pioneer rounds of

translation</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100078 1-B-W3-8-O/PPresentation: 7min,

Discussion: 2minMasahiro Nagata

Department of Molecular Immunology, Research

Institute for Microbial Diseases, Osaka

University, Osaka, Japan

Intracellular metabolite, &beta;-glucosylceramide, is an endogenous adjuvant acting through

Mincle

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100079 1-E-W9-14-P Poster Presentation Hideo NegishiDepartment of Molecular Immunology, Institute

of Industrial Science, The University of Tokyo,

Tokyo, Japan

Identification and analysis of commensal bacteriophage in the intestineDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100080 1-E-W9-2-O/PPresentation: 7min,

Discussion: 3minImai Takashi

Division of Molecular Immunology, Medical

Institute of Bioregulation, Kyushu University,

Fukuoka, Japan

<strong>Glycolipids in group A <em>Streptococcus </em>are recognized by Mincle to

trigger host immune responses</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100081 2-G-W23-16-O/PPresentation: 10min,

Discussion: 3minMAYUMI UETA

Departments of Frontier Medical Science and

Technology for Ophthalmology, Kyoto Prefectural

University of Medicine, Kyoto, Japan

Difference in the tear cytokines between chronic Stevens-Johnson syndrome patients and

Atopic keratoconjunctivitis

Dec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100082 1-I-W18-2-O/PPresentation: 7min,

Discussion: 3minSHINYA TANAKA

Research Institute for Biomedical Sciences,

Tokyo University of Science, Chiba, Japan

<strong>Tripartite motif-containing 33 (Trim33) mediates a pro-inflammatory phenotype of

Th17 cells.</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100083 3-G-W39-1-P Poster Presentation Tatsuhiko OzawaDepartment of Immunology, Graduate School of

Medicine and Pharmaceutical Sciences,

University of Toyama, Toyama, Japan

Evolution of anti-citrullinated peptide antibody (ACPA): analysis of autoantigen under native

condition using a human monoclonal ACPA

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100084 3-G-W39-8-O/PPresentation: 7min,

Discussion: 4minNoriko Arase

Department of Immunochemistry, Research

Institute for Microbial Diseases, Osaka UniversityRecognition of SS-A/IgG/HLA-DR complex by autoantibodies in Sjogren&rsquo;s syndrome

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100085 2-A-W19-15-P Poster Presentation Kazuaki NakataCollege of Bioresource Sciences, Nihon

University, Kanagawa, Japan

miR-21-5p regulates intestinal epithelial permeability through ADP-ribosylation factor 4

(ARF4)

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100086 3-F-W37-8-P Poster Presentation

Tomomi

Hashizume-

Takizawa

Nihon University School of Dentistry at Matsudo,

Chiba, Japan

Surface IgA<sup>+</sup> Peyer&rsquo;s patch B cells play key roles for induction of

recombinant <em>Salmonella</em>-derived antigen-specific intestinal IgA antibody

responses

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100087 1-F-W12-2-O/PPresentation: 10min,

Discussion: 3minHarada Michishige

RIKEN Center for Integrative Medical Science

(IMS)

CD81 is associated with non-apoptotic cell death in B cell lymphoma cell lines through HLA-

DR&alpha;/&beta; engagement

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100088 1-I-W18-16-P Poster Presentation Izumi KurataDivision of Rheumatology, Department of

Internal Medicine, Faculty of Medicine, University

of Tsukuba, Tsukuba, Japan

The Role of Follicular Helper 17 T cells and Desialylation of Autoantibody in Glucose-6-

phosphate Isomerase Induced Arthritis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100089 3-E-W34-7-O/PPresentation: 7min,

Discussion: 3minMineto Ota

The Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

Abnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of

immune cells

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100090 2-A-W19-11-O/PPresentation: 7min,

Discussion: 3minTomohiro FUKAYA

Division of Immunology, Department of

Infectious Diseases, Faculty of Medicine,

University of Miyazaki

Critical role of IL-22 binding protein in the control of skin inflammationDec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100091 2-F-W22-7-O/PPresentation: 8min,

Discussion: 3minKenta Kondo

Institute of Advanced Medical Sciences,

University of Tokushima, Tokushima, Japan.

Thymoproteasome-dependent positive selection conditions <em>in vivo</em> immune

responses in CD8<sup>+</sup> T cells

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100092 2-B-W20-15-P Poster PresentationNobuhito

NEMOTODepartment of immunology, Yamagata

University, Yamagata, Japan

Integrated analysis of intestinal immunity at initial onset and relapse stages in arthritis mouse

model

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100093 1-E-W9-18-P Poster Presentation Masanori IsekiDepartment of Immunology and Molecular

Genetics, Kawasaki Medical School, Kurashiki,

Japan

BST-1/CD157 on B cells negatively regulates Toll-like receptor signalingDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100094 2-I-W25-3-O/PPresentation: 7min,

Discussion: 3minHisako Kayama

Graduate School of Medicine, Osaka University,

Suita, Japan

Spi-C inhibits expression of a subset of Toll-like receptor 4-inducible genes in intestinal

CX<sub>3</sub>CR1<sup>high</sup> macrophages and prevents colonic inflammation

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100095 1-B-W3-14-P Poster Presentation Shimpei WatanabeR&amp;D Innovation Group, Kracie Holdings,

Ltd., Tokyo, JapanArctigenin suppresses the activation of NLRP3 and AIM2 inflammasomes.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100096 2-B-W20-6-O/PPresentation: 7min,

Discussion: 3minSonia Zeggar

Department of

Nephrology,Rheumatology,Endocrinology and

Metabolism,Okayama University graduate school

of medecine,Okayama,Japan

Lgals9 deficiency attenuates nephritis and arthritis in pristane induced mice model of SLEDec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

4 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100097 1-G-W13-16-O/PPresentation: 6min,

Discussion: 2minYasuyuki Saito

Division of Molecular and Cellular Signaling,

Department of Biochemistry and Molecular

Biology, Kobe University Graduate School of

Medicine, Kobe, Japan

SIRP&alpha;<sup>+</sup> dendritic cells regulate homeostasis of fibroblastic reticular cells

via TNF receptor ligands in the adult spleen

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100098 3-D-W32-12-P Poster Presentation Hidemi TakahashiDepartment of Microbiology and Immunology,

Nippon Medical School, Tokyo, Japan

<strong>Suppression of murine tumor growth through CD8+ CTLs via activated DEC-205+

dendritic cells by sequential administration of &alpha;-galactosylceramide in vivo: A possible

mechanism for SSM (Maruyama Vaccine)</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100099 1-C-W6-3-P Poster Presentation Masato KinoshitaDepartment of Nephrology and Rheumatology,

Gunma University Graduate School of Medicine,

Gunma, Japan

Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp-1 induces

autoimmune sialadenitis characterized by infiltration of CD4<sup>+</sup> T cells and B

cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100100 1-A-W1-4-O/PPresentation: 7min,

Discussion: 3minKoji Hayashizaki

Department of Immunology, Graduate School of

Medicine, Chiba University, Chiba, Japan

Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway

inflammation

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100101 2-F-W22-5-O/PPresentation: 8min,

Discussion: 3minSatoshi Kojo

Lab. for Transcriptional Regulation, RIKEN IMS,

Yokohama, Japan

Regulation of Runx3 activity in immune system development by the C-terminal end amino

acid sequence

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100102 1-D-W7-5-O/PPresentation: 6min,

Discussion: 2minTatsuya Yamazaki

Department of Microbiology and Immunology,

Aichi Medical University, School of Medicine

<strong>Neutralizing anti-hemagglutinin IgG and IgA mAb induced by gene-base

hydrodynamic injection have a therapeutic effect in<u> upper respiratory influenza virus

infection</u></strong>

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100103 3-E-W34-1-O/PPresentation: 7min,

Discussion: 3minSachiko Hirose

Toin Human Science and Technology Center,

Department of Biomedical Engineering, Toin

University of Yokohama, Yokohama, Japan

<strong>Independent effect of inhibitory </strong><strong>IgG Fc receptor</strong>

<strong>IIB on</strong><strong> B cells and monocytes </strong><strong>on

<em>Yaa</em>-induced murine lupus</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100104 1-H-W16-9-O/PPresentation: 6min,

Discussion: 2minKazuko Uno Louis Pasteur Center for Medical Research

Using non-negative matrix factorization analysis of IFN/Cytokine production and those of

serum levels to identify groups at high-risk of disease or those in the early stages of disease

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100105 1-H-W16-12-P Poster Presentation Toshikazu KondoDepartment of Forensic Medicine, Wakayama

Medical University, Wakayama, JapanThe absence of CCL3 exaggerates CaCl<sub>2</sub>-induced aortic aneurysm

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100106 3-D-W32-8-P Poster Presentation Shinsuke NakajimaDivision of Immunology and Molecular Biology,

Cancer Research Institute, Kanazawa University,

Ishikawa, Japan

Caspase-1-induced pyroptosis potentiates anti-tumor immunityDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100107 1-H-W15-5-O/PPresentation: 6min,

Discussion: 2minMizuho Nosaka

Department of Forensic Medicine, Wakayama

Medical University, Wakayama, Japan

Absence of CCR5 axis exaggerates thrombus formation through reduced uPA, tPA and

VEGF expression in murine DVT mode

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100108 1-E-W9-7-P Poster Presentation Krisana AsanoDepartment of Microbiology and Immunology,

Hirosaki University Graduate School of Medicine,

Aomori, Japan

<strong>Establishment of a mouse uterine infection model of <em>Staphylococcus aureus

</em>for studying a role of toxic shock syndrome toxin-1</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100109 1-G-W13-4-O/PPresentation: 6min,

Discussion: 2minTakao Sudo

Department of Immunology and Cell Biology,

Osaka University Graduate School of Medicine,

Osaka, Japan

Stressed microenvironment induced by 5-FU promotes the proliferation of HSPC in bone

marrow

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100110 1-A-W2-9-O/PPresentation: 7min,

Discussion: 3minDat Nguyen-Tien

Division of Molecular Biology, Research Institute

for Biomedical Sciences, Tokyo University of

Science

<strong>A selection technique for human IgE<sup>+</sup> memory B cells and the

function of the &ldquo;new&rdquo; isoform of human IgE</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100111 1-I-W17-8-P Poster Presentation Segawa SeijiDepartment of Internal Medicine, Faculty of

Medicine, University of Tsukuba, Japan.The analysis of placenta specific 8 in monocytes from Adult Still&rsquo;s disease

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100112 3-I-W43-16-P Poster Presentation Ruka SetoguchiRIKEN Center for Integrative Medical Sciences,

Kanagawa, Japan

<strong>Impairment of memory CD8 T cell maintenance in MHC class II deficient mice is

caused by inflammation not by CD4 T cell deficiency</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100113 1-A-W2-10-O/PPresentation: 7min,

Discussion: 3minMariana Almeida

Department of Immunology, Faculty of Medicine,

University of Tsukuba, Tsukuba, Japan

Inhibition of house dust mite-induced MAP kinase activation in dendritic cells by Allergin-1

immunoreceptor

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100114 3-D-W33-8-O/PPresentation: 7min,

Discussion: 3minMarija Mojic

Division of Pathogenic Biochemistry Institute of

Natural Medicine, University of Toyama, Toyama,

Japan

<strong>Tumor-specific CTL&#39;s reduced clonality and proliferation index, not the

inhibitory immune checkpoint expression, as hallmarks of B16 melanoma immune

evasion</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100115 1-H-W15-10-P Poster Presentation Takehiko ShibataDepartment of Immunology, National Institute of

Infectious Diseases, Tokyo, JapanThe role of RSV-induced Gas6/Axl signaling in secondary bacterial infection.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100116 1-D-W7-4-O/PPresentation: 6min,

Discussion: 2minKayoko Sato

Influenza Virus Research Center, National

Institute of Infectious Diseases, Tokyo, Japan

TLR agonists enhance avidity and ADCC activities of virus-specific antibodies upon a

booster immunization of influenza vaccines

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100117 2-A-W19-8-O/PPresentation: 7min,

Discussion: 3minTakahiro Nagatake

Laboratory of Vaccine Materials and Laboratory

of Gut Environmental System, National Institutes

of Biomedical Innovation, Health and Nutrition

(NIBIOHN), Osaka, Japan

17,18-EpETE, a metabolite of omega-3 essential fatty acids, inhibited neutrophil mobility

and ameliorated skin inflammation in DNFB-induced contact hypersensitivity model

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100118 2-A-W19-2-P Poster Presentation Siddhika PareekLaboratory of Immune Regulation, Graduate

School of Medicine, Osaka University, Osaka,

Japan

<strong>Comparative analysis of gut microbiome diversity between Japanese and Indian

cohorts exhibits a diet-dependent synergism between bacteria and fungi</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

5 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100119 2-B-W20-9-O/PPresentation: 7min,

Discussion: 3minNorio Hanata

Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

The effects of <em>peptidylarginine deiminase 4</em> in imiquimod-induced lupus model

mice.

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100120 3-H-W40-5-P Poster Presentation Kyosuke InuiDepartment of Immunology, Graduate School of

Pharmaceutical Sciences, Hokkaido University,

Hokkaido, Japan

STAP-2 negatively controls Fc&epsilon;RI-mediated mast cell activation.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100121 1-E-W10-13-P Poster Presentation Sonoko TasakiSection of Infection Biology, Department of

Functional Biosciences, Fukuoka Dental College.Investigation of mechanisms underlying the T cell response in oral candidasis.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100122 3-H-W40-6-P Poster Presentation Kazumi KasakuraDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

The effect of commensal bacteria on anaphylactic reactionDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100123 2-C-W21-5-P Poster Presentation Shuhei YonamineDepartment of Dermatology, Graduate School of

Medicine, University of the Ryukyus, Nishihara,

Okinawa, Japan.

Rapid isolation of tumor antigen specific antibodies from semi-synthetic alpaca VHH phage

display library for cancer immunotherapy.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100124 1-G-W13-15-P Poster Presentation Krutula NairRIKEN Center for Integrative Medical Sciences,

Yokohama, JapanA ThPOK-independent CD4-skewed differentiation by loss of Tet proteins and SATB1

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100125 3-F-W37-19-P Poster Presentation Naoto YoshinoDivision of Infectious Diseases and Immunology,

Department of Microbiology, School of Medicine,

Iwate Medical University, Iwate, Japan

Mucosal adjuvanticity of surfactin correlates with the surface-active propertyDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100126 3-E-W35-2-O/PPresentation: 7min,

Discussion: 3minMayuko Shimoda

Laboratory of Host Defense, Research Institute

for Microbial Diseases Osaka University, Suita,

Osaka, Japan

<strong>GANP maintains antibody structural integrity during somatic

hypermutation</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100127 3-G-W38-1-O/PPresentation: 7min,

Discussion: 4minShigeru Iwata

The First Department of Internal Medicine,

School of Medicine, University of Occupational

&amp; Environmental Health, Japan, Kitakyushu,

Fukuoka, Japan

<strong>IFN-</strong><strong>&gamma;</strong><strong>-T-bet mediated metabolic

reprograming in T</strong> <strong>helper 1cells</strong><strong>and </strong><strong>its relevance topathogenesis of SLE</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100128 2-A-W19-16-O/PPresentation: 7min,

Discussion: 3minYuki Usui

Division of Systems Immunology, Institute of

Medical Science, The University of Tokyo

<strong>Maintenance of intestinal barrier function by long-term intake of LB81

yogurt</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100129 1-C-W5-7-O/PPresentation: 7min,

Discussion: 3minSatoshi Yamada

Department of Intelligent Mechanical

Engineering, Okayama University of Science,

Okayama, Japan

Computer model of a gateway of immune cells across blood-brain barrierDec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100130 3-A-W26-5-O/PPresentation: 10min,

Discussion: 3minShigenori Nagai

Department of Molecular Immunology, Tokyo

Medical and Dental University, Tokyo, JapanPI3K-Akt pathway enhances type 1 regulatory T cell differentiation induced by IL-27

Dec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100131 2-B-W20-4-O/PPresentation: 7min,

Discussion: 3minTakamasa Cho

Division of Clinical Nephrology and

Rheumatology,Niigata University, Niigata,JapanAnti-ribosomal-P antibody induces psychosis and hepatitis

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100132 3-G-W39-9-O/PPresentation: 7min,

Discussion: 4minYoshinobu Koyama

Center for Autoimmune Diseases, Division of

Rheumatology, Japan Red Cross Okayama

Hospital,Okayama, Japan

Exercise-induced pulmonary hypertension at early stage of systemic sclerosis: changes in

gene expression of peripheral blood cells

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100133 2-F-W22-12-P Poster Presentation Ryo YokotaInstitute of Industrial Science, the University of

Tokyo, Tokyo, JapanQuantification of inter-sample differences in repertoire of T cell receptors

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100134 2-F-W22-10-O/PPresentation: 8min,

Discussion: 3minKazumasa Kaneko

Graduate School of Engineering, The University

of Tokyo, Tokyo, Japan

Mathematical modeling of thymic T cell development via interaction with thymic epithelial

cells

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100135 1-I-W18-5-P Poster Presentation Kyoko NISHIDADepartment of Immunology and Pathology,

National Center for Global Health and Medicine

NQO1 play a pathogenic role in autoimmune diseases through the suppression of IL-10

production in Th17 cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100136 1-E-W9-3-P Poster Presentation Yukiko AkahoriInternational University of Health and Welfare,

Narita, Japan

Dectin-1 mediates innate immune responses in <em>Streptococcus pneumoniae</em>

infection

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100137 1-E-W9-12-P Poster Presentation Shiho SuzukiDept Bacterial Infection and Host Responce,

Tokyo Medical and Dental Univ (TMDU), Tokyo,

Japan

The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in

<em>Shigella</em>-infected macrophages

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100138 1-C-W6-1-O/PPresentation: 7min,

Discussion: 3minOta Mitsutoshi

Division of Psychoimmunology, Institute for

Genetic Medicine, Hokkaido University, Sapporo,

Japan

<strong>NF-kB Arthritis Inducer 1 (NAI1) in chondrocytes regulates joint inflammation via

NF-kB activation</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100139 3-D-W33-15-P Poster PresentationNaoko Kumagai-

TakeiDepartment of Hygiene, Kawasaki Medical Scool,

Kurashiki, Japan

The analysis for function of human CD8+T cell line with and without long-term exposure to

asbestos fibers

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100140 3-I-W43-15-O/PPresentation: 7min,

Discussion: 3minMichio Miyajima

Laboratory for Mucosal Immunity, Center for

Integrative Medical Sciences, RIKEN Yokohama

Institute, Yokohama, Japan

Systemic metabolic shift induced by PD-1 deficiency perturbs brain monoamines and

emotional behaviour

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

6 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100141 1-H-W16-13-P Poster Presentation Yasu-Taka Azuma

Laboratory of Veterinary Pharmacology, Division

of Veterinary Science, Osaka Prefecture

University Graduate School of Life and

Environmental Science, Izumisano, Japan

Exacerbated TNBS-induced colitis in interleukin-19 knockout miceDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100142 2-C-W21-2-P Poster Presentation Hiroshi Hamana

Department of Innovative Cancer

Immunotherapy, Graduate School of Medicine

and Pharmaceutical Sciences, University of

Toyama, Japan

T cell receptor (TCR) gene cloning from tumor infiltrating lymphocytes of breast cancer

patients toward TCR gene therapy

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100143 2-B-W20-18-P Poster Presentation Yuki TanakaPsychoimmunology, Institute for Genetic

Medicine, Hokkaido University, Sapporo, Japan

<strong>Enriched environment, which might suppresses the Gateway Reflex attenuated the

development of EAE via inhibiting immune cell accumulation in the L5 spinal cord.</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100144 1-E-W10-7-O/PPresentation: 7min,

Discussion: 3minYasunobu Miyake

Division of Molecular and Cellular

Immunoscience, Department of Biomolecular

Sciences, Faculty of Medicine, Saga University,

Saga, Japan

Immunosuppressive receptor, Siglec binds to pathogenic fungus, <em>Trichophyton

mentagrophytes</em>, and negatively regulates host immune responses

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100145 2-H-W24-14-P Poster Presentation Caroline M. Kijogi

Division of Immunology, Department of

Molecular Microbiology and Immunology,

Graduate School of Biomedical Sciences,

Nagasaki University, Nagasaki, Japan.

<strong>T-cell responses to <em>Plasmodium falciparum </em>and <em>Schistosoma

mansoni </em>infections in asymptomatic children living in the endemic region of Mbita,

western Kenya.</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100146 1-H-W16-4-O/PPresentation: 6min,

Discussion: 2minYurina Miyajima

Laboratory for Innate Immune Systems, RIKEN

IMSFunction of BMP2 and BMP7 produced by ILC2 in the adipose tissue

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100147 3-B-W29-5-O/PPresentation: 11min,

Discussion: 2minNatsuko Otaki

Laboratory for Innate Immune Systems, RIKEN

IMSThe role of group 2 innate lymphoid cells in pulmonary fibrosis

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100148 3-C-W31-6-O/PPresentation: 8min,

Discussion: 3minSayako Chiba

Division of Gastroenterology and Hepatology,

Department of Internal Medicine, Keio University

School of Medicine, Tokyo, Japan

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophagesDec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100149 3-C-W31-7-O/PPresentation: 8min,

Discussion: 3minAkihiro Kimura

Dept. of Immunology and Pathology, Research

Institute National Center for Global Health and

Medicine, Chiba, Japan

<strong>The novel ubiquitin ligase complex, NQO1-PDLIM2 inhibits TLR-dependent

production of selective cytokines by degrading I&kappa;B-&zeta;</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100150 1-H-W15-7-O/PPresentation: 6min,

Discussion: 2minKeiko Yoshimoto

Division of Rheumatology, Department of

Internal Medicine, Keio University School of

Medicine, Tokyo, Japan

BAFF signaling inhibitors ameliorate enhanced production of IL-6 and IL-10 by pSS

monocytes and consequently suppress IgG overproduction by affecting differentiation of B

cells.

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100151 3-G-W38-5-P Poster Presentation Kato YasuhiroDepartment of Respiratory Medicine and Clinical

Immunology, Graduate School of Medicine,

University of Osaka, Japan

The role of Stimulator of interferon genes (STING) in the pathogenesis of SLEDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100152 3-I-W43-12-P Poster Presentation Yumiko KannoDepartment of Immunology, Dokkyo Medical

University School of Medicine, Mibu,

Shimotsuga, Tochigi, Japan

HIF-1&alpha; plays a key role in regulation of homeostatic energy metabolism in cytotoxic T

lymphocytes.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100153 1-A-W2-3-P Poster Presentation Dong-Young KimDepartment of Otorhinolaryngology-Head and

Neck Surgery, Seoul National University College

of Medicine, Seoul, Korea

Anti-allergic effect of intranasal vitamin D treatment by inhibiting dendritic cell activation in

the allergic rhinitis mouse model

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100154 1-I-W17-15-O/PPresentation: 7min,

Discussion: 3minIwamoto Sanju

Division of Physiology and Pathology,

Department of Pharmacology, Toxicology and

Therapeutics, Showa University of Pharmacy,

Tokyo, Japan

Atypical development of human Th17 lineage from na&iuml;ve CD4 T cells in psoriasis.Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100155 3-F-W37-14-P Poster Presentation Hideo KataokaDepartment of Oral Microbiology, Showa

University School of Dentistry, Tokyo, JapanMALDI-TOF-MS Analysis of gut microbiota in murine model of food allergy

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100156 3-G-W38-3-O/PPresentation: 7min,

Discussion: 4minYusuke Takeshima

1Department of Allergy and Rheumatology,

Graduate School of Medicine, the University of

Tokyo, Tokyo, Japan

Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in

peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells

to systemic lupus erythematosus.

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100157 3-B-W29-10-P Poster Presentation Shindo RyodaiToho University School of Medicine, Tokyo,

Japan

<strong>ROR&gamma;t-positive cells mediate RIPK3- and MLKL-dependent lethal ileitis in

neonatal mice</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100158 1-C-W5-4-O/PPresentation: 7min,

Discussion: 3minFumitaka Sato Kindai University, Osakasayama, Japan

Protective and detrimental effects of curdlan, a Th17 cell inducer, in immune-mediated

demyelination induced by a neurotropic viral infection

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100159 3-E-W34-10-P Poster Presentation Shoya YasudaDepartment of Computational Intelligence and

Systems Science, Tokyo Institute of Technology,

Yokohama, Japan

Mathematical modeling of BAFFR-mediated B cell survival signaDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100160 1-E-W10-4-O/PPresentation: 7min,

Discussion: 3min

Shihoko Komine-

Aizawa

Nihon University School of Medicine, Tokyo,

Japan

Induction of CD8<sup>+</sup>- MHC-I-restricted, antigen-specific T cells by recombinant

BCG protects against mycobacterial infection

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100161 1-H-W15-11-P Poster Presentation Yuji TakedaDepartment of Immunology, Yamagata University

Faculty of Medicine, Yamagata, Japan

Analysis of cytokine signals using flow cytometry is useful for detection of contractive and

fluctuating signals.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100162 2-A-W19-4-P Poster Presentation Masahisa HemmiGraduate School of Pharmaceutical Sciences,

Osaka University,Osaka, Japan

Th17 promotes the induction of antigen-specific gut-mucosal CTLs following intramuscular

vaccination of an adenovirus vector

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

7 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100163 3-C-W31-14-P Poster PresentationMohamad Alaa

Terkawi

Department of Orthopedic Surgery, Faculty of

Medicine and Graduate School of Medicine,

Hokkaido University, Sapporo, Japan

Transcriptional profile of human macrophages stimulated by ultra-high molecular weight

polyethylene particulate debris of orthopaedic implants uncovers a common gene

expression signature of rheumatoid arthritis

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100164 2-G-W23-3-O/PPresentation: 10min,

Discussion: 3minSeiji Kamijo

Atopy (Allergy) Research Center, Juntendo

University Graduate School of Medicine, Tokyo,

Japan

Protease allergen-induced local IL-17A production in skin tissue and accumulation of IL-

17A<sup>+</sup> &gamma;&delta; T cells in skin draining lymph nodes; possible

contribution to enhancement of skin eosinophilia and serum IgE response

Dec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100165 1-H-W16-14-P Poster Presentation Kyosuke KanaiDepartment of Virology, Tottori University Faculty

of Medicine, Yonago, JapanRole of IL-35 in Lipopolysaccharide-Induced Airway Eosinophilia

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100166 3-A-W26-4-O/PPresentation: 10min,

Discussion: 3minDaisuke Kimura

Division of Immunology, Department of

Molecular Microbiology and Immunology,

Nagasaki University Graduate School of

Biomedical Sciences, Nagasaki, Japan

Interleukin-27-dependent loss of CD4<sup>+</sup> T cell-memory during malaria infectionDec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100167 3-C-W31-9-O/PPresentation: 8min,

Discussion: 3minTakuya Yashiro

Department of Biological Science and

Technology, Faculty of lndustrial Science and

Technology, Tokyo University of Science, Tokyo,

Japan

Defect of NR4A3 leads to impaired ability of migration in intestinal dendritic cellsDec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100168 2-H-W24-2-O/PPresentation: 7min,

Discussion: 3minMana Miyakoda

Division of Immunology, Department of

Molecular Microbiology and Immunology,

Graduate School of Biomedical Sciences,

Nagasaki University

Mechanisms underlying metformin-mediated enhancement of the protective immune

responses against malaria infection.

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100169 2-A-W19-6-P Poster Presentation Ito SayamiProject for Vaccine and Immune Regulation,

Graduate School of Pharmaceutical Sciences,

Osaka University

Elucidation of the induction mechanism of transcutaneous immune responses with the self-

dissolving microneedle patch

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100170 1-D-W8-9-O/PPresentation: 6min,

Discussion: 2.5minTakahisa Kouwaki

Department of Immunology, Graduate school of

Medical Sciences, Faculty of Life Sciences,

Kumamoto University, Kumamoto, Japan

<strong>Zyxin</strong> <strong>is a positive factor in a MAVS/IPS-1-dependent

</strong><strong>type</strong> <strong>?</strong> <strong>interferon</strong>

<strong>expression pathway during viral infection.</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100171 2-I-W25-9-P Poster Presentation Hideki MinematsuKatayama Chemical Industries Co.,Ltd, Osaka,

Japan

Effects of liposome-encapsulated clodronate which can deplete macrophages <em>in

vivo</em>.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100172 1-C-W6-6-O/PPresentation: 7min,

Discussion: 3minTomomi Sato

Department of Fundamental Biosciences, Shiga

University of Medical Science, Shiga, Japan

Characterization of rheumatoid arthritis-associated interstitial pneumonia using collagen-

induced arthritis mice

Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100173 1-I-W18-6-P Poster PresentationNobumasa

WatanabeTokyo Metropolitan Institute of Medical Science,

Tokyo, JapanMHC-II-dependent autonomous immune responses of in vitro-differentiated Th17 cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100174 3-D-W32-2-P Poster Presentation Ayumi HongoDepartment of Pathology, Sapporo Medical

University, Sapporo, Japan

Presence of proline in N-terminal extensions of epitope sequences influences HLA-A24

antigen processing and decreases CD8+ T-cell responses

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100175 3-F-W37-6-O/PPresentation: 7min,

Discussion: 2minHideaki Takagi

Division of Immunology, Department of

Infectious Diseases, Faculty of Medicine,

University of Miyazaki

Tolerogenesis of gastrointestinal plasmacytoid dendritic cells impacts the induction of oral

tolerance

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100176 1-F-W12-3-P Poster Presentation Makoto KuboDivision of Immunology, Kitasato University

School of Allied Health Sciences, Kanagawa,

Japan

Analysis of immune responses in prostate cancer patients received iridium-192 high-dose-

rate prostate brachytherapy

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100177 1-D-W8-4-O/PPresentation: 6min,

Discussion: 2.5minTakamasa Ueno

Center for AIDS Research, Kumamoto

University, Kumamoto, Japan

<strong>Relative resistance of MHC-B to Nef-mediated downregulation is conserved

among primate lentiviruses and correlates with reduced viral loads in HIV-1-infected

individuals</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100178 3-I-W42-9-O/PPresentation: 7min,

Discussion: 3minEun Jeong Park

Mie University Graduate School of Medicine,

Mie, Japan&beta;7 integrin-mediated homing of exosomes to the gut

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100179 2-A-W19-1-P Poster Presentation Jianshi JinRIKEN Quantitative Biology Center (QBiC),

Osaka, Japan

A novel high-throughput method for bacteria counting based on <em>de-novo</em> 16S

rRNA sequence identification with single-base resolution

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100180 1-I-W17-14-O/PPresentation: 7min,

Discussion: 3minDaisuke SUZUKI

Center for iPS Cell Research and Application,

Kyoto University, Kyoto, Japan

Differential natural killer (NK) cell immunity against class-I human leukocyte antigen (HLA)-

knockout (KO) platelets and megakaryocytes

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100181 1-B-W3-7-O/PPresentation: 7min,

Discussion: 2minHo Minh Van

Department of Emergency and Critical Care

Medicine, Graduate School of Biomedical and

Health Sciences, Hiroshima University

<strong>Detection of ATP-dependent inflammatory suppression of the innate immune

response in septic patients</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100182 1-F-W11-5-P Poster Presentation Etsuko HaradaDepartment of Immunology, Mie University

School of Medicine, Mie, Japan

<strong><em>Agaricus blazei</em></strong><strong> Murrill extract

inhibits</strong><strong> the expression of immune checkpoint molecules in a lung cancer

cell line</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100183 2-F-W22-13-P Poster Presentation Hiromichi TsuruiDepartment of Pathology, Juntendo University

School of Medicine

Precise estimation of residue-residue interaction in TCR-pMHC complex by Fragment

Molecular Orbitan (FMO) calculation

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100184 2-F-W22-2-O/PPresentation: 8min,

Discussion: 3minKatsuto Hozumi

Tokai University School of Medicine, Isehara,

Japan

Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages

in hematopoietic stem/progenitor cells by Lmo2

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

8 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100185 3-D-W33-10-P Poster Presentation Wakana GotoLaboratory of Hematology and Oncology,

Graduate School of Health Sciences, Niigata

University, Japan

<strong>Clonal amplification of WT1 specific CTL using dendritic cell line.</strong>Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100186 3-D-W32-11-O/PPresentation: 7min,

Discussion: 3minHisashi Kanemaru

Research Institute for Microbial Diseases

(RIMD), Osaka University, Osaka, Japan

Basic leucine zipper transcription factor ATF-like 2 exhibits an anti-tumor effect through

upregulation of IL-12 p40 expression

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100187 3-I-W43-1-O/PPresentation: 7min,

Discussion: 3minJisu Ma

Department of Immunoparasitology, Research

Institute for Microbial Diseases, Osaka

University, Osaka, Japan

<strong>PLC&beta; plays an important role in CD8 T cell-mediated host defense against

<em>Toxoplasma gondii</em></strong>

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100188 1-B-W3-5-O/PPresentation: 7min,

Discussion: 2minNaoya Sakaguchi

Research Institute for Microbial Diseases

(RIMD), Osaka University, Osaka, Japan

<strong>Role of GABARAP subfamily in the regulation of non-canonical inflammasome

activation</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100189 1-A-W1-9-O/PPresentation: 7min,

Discussion: 3minAiko Saku

Department of Allergy and Clinical Immunology,

Graduate School of Medicine, Chiba University,

Chiba, Japan

Lung epithelial fucosylation promotes the development of house dust mite (HDM)-induced

allergic airway inflammation.

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100190 3-D-W32-1-O/PPresentation: 7min,

Discussion: 3minYasuhiro Kikuchi

Department of Pathology, Sapporo Medical

University School of Medicine, Sapporo, JapanA novel HLA class I peptide encoded by a long non-coding RNA

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100191 2-B-W20-3-P Poster Presentation Atsushi NomuraDepartment of Immunology, Juntendo University

School of Medicine, Tokyo, JapanComparative analysis of neuroinflammation in Lupus-prone mice

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100192 1-F-W12-6-O/PPresentation: 10min,

Discussion: 3minKikuya Sugiura

Department of Advanced Pathobiology, Graduate

School of Life and Environmental Sciences,

Osaka Prefecture University, Izumisano, Japan

Manipulation of tumor microenvironment by cytokine gene transfection enhances dendritic

cell-based immunotherapy

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100193 1-H-W15-12-P Poster PresentationYAMAMOTO

ShinyaDivision of Chemotherapy, Kindai University

Faculty of Pharmacy, Osaka, Japan

A highly active form of lymphotactin/XCL1 (XCL1-CC3) functions as a potent adjuvant to

accumulate CD103+XCR1+ cross-presenting dendritic cells and induce CD8+ CTL-

mediated antitumor and antiviral effects

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100194 3-I-W42-2-P Poster Presentation Saitoh KodaiDepartment of Immunology, Faculty of

Pharmaceutical Sciences, Hokkaido University,

Hokkaido, Japan

A role of STAP-2 in T cell activation and T cell-mediated immune responsesDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100195 1-H-W15-13-P Poster PresentationKAMBARA

HirokazuDivision of Chemotherapy, Kindai University

Faculty of Pharmacy, Osaka, Japan

CCL28-deficiency altered microbiota in the colon and aggravated DSS-induced colitis in

mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100196 2-B-W20-7-O/PPresentation: 7min,

Discussion: 3minShin-Ichiroh Saitoh

The Institute of Medical Science, The University

of Tokyo, Tokyo, Japan.

ADP-libosylation factor-like 8b is required for pathogenesis of mouse models of Systemic

Lupus Erythematosus

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100197 1-H-W15-14-P Poster PresentationMATSUO

KazuhikoDivision of Chemotherapy, Kindai University

Faculty of Pharmacy, Osaka, Japan

CCR4 is involved in atopic dermatitis-like skin lesions induced by topical sensitization of

ovalbumin and &delta;-toxin using a hydrogel patch in mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100198 3-E-W34-2-O/PPresentation: 7min,

Discussion: 3minHisashi Nomura

Department of Dermatology, Keio University

School of Medicine, Tokyo, Japan

Fc&gamma;RIIb plays an important role in maintaining clonal ignorance and prevents

pemphigus phenotype in pathogenic anti-desmoglein 3 antibody knock-in mice

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100199 1-A-W1-14-O/PPresentation: 7min,

Discussion: 3minKatsuhide Okunishi

Institute for Molecular and Cellular Regulation,

Gunma University, Maebashi, JapanRab27 effector exophilin5 regulates IL-33 signaling in allergic immune responses

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100200 1-F-W12-7-P Poster Presentation Mariko TakamiDepartment of Medical Immunology, Graduate

School of Medicine, Chiba University, Chiba,

Japan

AhR signaling enhances the moDC function to activate NKT cellsDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100201 2-G-W23-4-P Poster Presentation

Worawalun

HIRUNWIDCHAY

ARAT

Department of Molecular Immunology, Graduate

School, Tokyo Medical and Dental University.

Site-specific regulation of oral mucosa-recruiting CD8<sup>+</sup> T cells -Comparison of

contact allergy between skin and oral mucosa-

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100202 1-B-W4-11-P Poster Presentation HAI T PHUNGDepartment of Microbiology and Immunology,

Tohoku University Graduate School of Medicine,

Sendai, Japan

TNF receptor-associated factors 5 expressed in non-hematopoietic cells augments acute

colonic damage induced by dextran sulfate sodium

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100203 1-A-W2-11-P Poster PresentationHirotomo

ShibaguchiDepartment of Biochemistry, Faculty of

Medicine, Fukuoka University, Fukuoka, JapanGene analysis of HL-60 cells and neutrophils to generate ideal chemotactic cells for HiSAT

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100204 1-G-W13-8-O/PPresentation: 6min,

Discussion: 2minYohei Kawano

Department of Immune Regulation, Tokyo

Medical and Dental Universiy Graduate School,

Tokyo, Japan

Establishment of a novel culture system for long-term proliferating hematopoietic progenitors

with lymphoid and myeloid potential from normal mouse bone marrow without genetic

manipulations

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100205 1-A-W2-12-O/PPresentation: 7min,

Discussion: 3minShihono Kato

Laboratory for Innate Immune Systems, RIKEN,

IMS, Kanagawa, Japan

Role of ILC2 in the formation of maternal allergic inflammation and allergic susceptibility of

the offspring

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100206 2-H-W24-10-O/PPresentation: 7min,

Discussion: 3min

Odsuren

Sukhbaatar

Department of Molecular Microbiology and

Immunology, Nagasaki University Graduate

School of Biomedical Science, Nagasaki, Japan

Role of Interleukin-27 in the regulation of immune responses against chronic malaria

infection

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

9 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100207 1-I-W18-4-O/PPresentation: 7min,

Discussion: 3minYuko Okuyama

Department of Microbiology and Immunology,

Tohoku University Graduate School of Medicine,

Miyagi, Japan

A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by

CD4<sup>+</sup> T cells

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100208 3-C-W31-12-O/PPresentation: 8min,

Discussion: 3minTakeshi Nakatani

Department of respiratory medicine and clinical

immunology, Osaka Univ., Osaka, JapanLamtor1 (p18) plays a crucial role in trafficking of dendritic cells.

Dec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100209 2-C-W21-3-P Poster Presentation Yusuke TakahashiDepartment of Immunology, Graduate School of

Medicine and Pharmaceutical Science,

University of Toyama, Japan

<strong>T cell receptor repertoire of PD-1<sup>+</sup>CD137<sup>+</sup> and PD-

1</strong><strong><sup>&minus;</sup></strong><strong>CD137</strong><strong><sup

>&minus;</sup></strong><strong> tumor infiltrating lymphocytes in various

cancers</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100210 1-D-W8-6-O/PPresentation: 6min,

Discussion: 2.5minNami Iwamoto

Immuno Technology Section, Vaccine Research

Center, NIAID, NIH

Development of Chimeric Antigen Receptor (CAR)-Transduced CD8 T cells Using SIV-

specific Neutralizing Anibodies

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100211 3-I-W43-4-P Poster Presentation Tomohiro Masuda 名古屋市昭和区 Growth factor Midkine promotes NFAT activation and Th1 differentiation in lupus NephritisDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100212 1-B-W4-13-P Poster Presentation Masaaki Toda Dept of Immunology<strong>Epigenetic mechanisms mediate the antiatherosclerotic activity of low consumption

of alcohol</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100213 2-G-W23-15-P Poster Presentation Chang-Hyun KimCollege of Medicine, Dongguk University,

Gyeonggi-do, South Korea

Protective effects of agonistic anti-4-1BB antibody on the development of imiquimod-

induced psoriasis-like dermatitis in mice

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100214 3-C-W30-13-O/PPresentation: 7min,

Discussion: 3min

Masafumi

NakayamaFrontier Research Institute for Interdisciplinary

Sciences, Tohoku UniversityIdentification of a silica receptor associated with canonical inflammasome activation.

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100215 3-H-W41-8-P Poster Presentation Taizo Mori

Department of Immune Regulation, The

Research Center for Hepatitis and Immunology,

Research Institute, National Center for Global

Health and Medicine

Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group1-ILCsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100216 1-B-W3-3-O/PPresentation: 7min,

Discussion: 2minKen Takashima

Department of Immunology, Graduate School of

Medicine, Hokkaido University, Sapporo, JapanNovel Negative Regulators for MDA5-Mediated Innate Immune Response

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100217 3-F-W36-10-P Poster PresentationKatsuhiro

Nakanishi

Laboratory of Microbiology and Immunology,

School of Pharmaceutical Sciences, University of

Shizuoka, Shizuoka, Japan

Production of secretory hybrid-IgG/IgA in plant expression systemDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100218 1-A-W1-16-P Poster PresentationPrince Baffour

TontoDept. of Immunology <strong>Role of eosinophils and metalloproteinase-2 in airway remodeling</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100219 2-H-W24-12-O/PPresentation: 7min,

Discussion: 3minShin-Ichi Inoue

Department of Infectious Diseases, Kyorin

University School of Medicine, Tokyo, Japan

<strong>Maintenance of immunological memory to malaria is impaired by

<em>Salmonella</em> infection</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100220 2-I-W25-10-P Poster Presentation Hiroki HIRAMALaboratory of Immunology, Graduate School of

Health Sciences, Niigata University, Niigata,

Japan

The effects of ovariectomy on autoimmune hepatitis and hepatic dendritic cells.Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100221 3-F-W37-15-O/PPresentation: 7min,

Discussion: 2minHidehiko Suzuki

Laboratory of Vaccine Materials and Laboratory

of Gut Environmental System, National

Institutes of Biomedical Innovation, Health and

Nutrition (NIBIOHN)

Development of divalent food poisoning vaccine by augmented antigenicity of

<em>Clostridium perfringens</em> enterotoxin

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100222 3-G-W39-4-O/PPresentation: 7min,

Discussion: 4minHaruka Tsuchiya

Department of Allergy and Rheumatology, The

University of Tokyo, Tokyo, Japan

Identification EP300 as a Novel Therapeutic Target for Rheumatoid Arthritis by the

Comprehensive Analysis of Fibroblast-like Synoviocytes

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100223 3-C-W30-7-P Poster Presentation Atsuo NakamuraDairy Science and Technology Institute, Kyodo

Milk Industry Co. Ltd.,Tokyo, Japan

<strong>Effect of polyamines on macrophage polarization and mucosal

inflammation</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100224 1-F-W12-12-O/PPresentation: 10min,

Discussion: 3minSerina Tokita

Department of Pathology, Sapporo Medical

University School of Medicine, Sapporo, JapanHLA-A24 ligandome analysis identifies a neoantigen that elicits strong CTL responses

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100225 3-H-W40-7-P Poster Presentation Nobuhiro NakanoAtopy (Allergy) Research Center, Juntendo

University Graduate School of Medicine, Tokyo,

Japan

Mast cells acquire intestinal antigen-presenting cell-like properties by Notch signalingDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100226 1-D-W7-10-O/PPresentation: 6min,

Discussion: 2minAkihiko Komuro

Niigata University of Pharmacy and Applied Life

Sciences, Niigata, Japan

A possible role of TAR-RNA binding protein phosphorylation in MDA5/LGP2-mediated

cellular responses by Cardiovirus infection

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100227 1-D-W8-10-P Poster Presentation Yoshihiro KumagaiDepartment of Microbiology and Immunology,

Nippon Medical School, Tokyo, Japan

<strong>THE ANALYSIS OF THE INTERACTION BETWEEN HIV-1 GP 120 AND

</strong><strong>b-CHEMOKINE RECEPTOR BY USING MULITIVALENT V3

EPITOPES GRAFTED AT IMMUNOGLOBULIN HYPERVARIABLE REGIONS </strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100228 1-F-W11-2-P Poster PresentationOuji-Sageshima

NorikoDepartment of Immunology, Nara Medical

University, Kashihara, JapanThe critical role of HLA class Ib proteins, HLA-E and HLA-F, expressed on tumor cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

10 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100229 1-G-W13-11-P Poster Presentation Akihisa Oda Chiba, Japan<strong>Niche-induced myeloproliferative-like disease caused by overexpression of Tlx1

i<em>n situ </em>in splenic stromal cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100230 3-E-W34-9-P Poster Presentation Hanbing XueGraduate School of Life and Environmental

Sciences, University of Tsukuba, Ibaraki, Japan

Examination of &ldquo;Universal Light Chain&rdquo; models that can be paired with a wide

spectrum of immunoglobulin heavy chains maintaining their antigen-binding specificities

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100231 1-C-W6-10-P Poster Presentation Hayakawa KunihiroInstitute for Environmental and Gender Specific

Medicine, Juntendo University Graduate School

of Medicine, Chiba, Japan

Possible mechanisms of anti-arthritic effect induced by dietary &omega;-3 polyunsaturated

fatty acids

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100232 1-A-W2-13-O/PPresentation: 7min,

Discussion: 3minMio Ohashi

Department of Immunoregulation, Institute of

Medical Science, Tokyo Medical University,

Tokyo, Japan

Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expressionin

Dendritic Cells Using a Novel 3D Co-Culture System

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100233 3-A-W26-1-O/PPresentation: 10min,

Discussion: 3minTakumi Maruhashi

Division of Immune Regulation, Institute for

Genome Research, Tokushima University,

Tokushima, Japan

Immuno-inhibitory co-receptor LAG-3 regulates immunodominance and autoimmunity by

virtue of its conformation-dependent recognition of MHCII

Dec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100234 3-C-W31-4-P Poster Presentation Naho IkariResearch &amp; Development Division,

Kikkoman Corporation, Chiba, Japan

Double-stranded RNA in lactic acid bacteria augments Th1 immunity via IFN-&beta;

secretion by human dendritic cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100235 1-A-W1-5-P Poster Presentation Ryuichi NagashimaDivision of Cancer Biology and Therapeutics,

Miyagi Cancer Certer Reserch Institute, Natori,

Japan

<strong>Nrf2 activation suppressed lung allergic inflammation induced by type2-innate

lymphoid cells.</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100236 3-G-W39-3-P Poster Presentation Shinji MaedaDepartment of Respiratory Medicine, Allergy and

Clinical Immunology, Nagoya City University

Graduate School of Medical Sciences

<strong>Exploratory study of T cell biomarkers predicting Abatacept treatment response in

RA patients with background adjustment by IPW method</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100237 3-C-W30-1-O/PPresentation: 7min,

Discussion: 3minJeong-Hwan Yoon

Biomedical Research Institute, Kyungpook

National University Hospital, Daegu, Korea

Repression of SMAD3 by STAT3 and c-SKI is essential for conventional dendritic cell

differentiation

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100238 2-H-W24-4-O/PPresentation: 7min,

Discussion: 3minSayuri Nakamae

Division of Immunology, Department of

Molecular Microbiology and Immunology,

Nakgasaki University Graduate School of

Biomedical Sciences, Nagasaki, Japan

Modulation of T-cell immune responses to pathogenic malaria parasites by prior infection

with different species of malaria parasites

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100239 3-A-W26-12-P Poster Presentation Manabu KinoshitaDepartment of Immunology and Microbiology,

National Defense medical College, Saitama,

Japan

<strong>LPS tolerance recruits CD11b<sup>+</sup> macrophages to the liver with

enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic

resistance to lethal septicemia</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100240 3-C-W30-2-O/PPresentation: 7min,

Discussion: 3minHaruka Sasaki

Department of Immunology, Yokohama City

University Graduate School of Medicine,

Yokohama, Japan

A novel distal enhancer responsible for <em>Irf8</em> expression in the mononuclear

phagocyte lineage

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100241 1-G-W13-12-O/PPresentation: 6min,

Discussion: 2minAkihisa Oda

Research Institute for Biomedical Sciences

Tokyo Universitiy of Science, Chiba, Japan

<strong>Niche-induced myeloproliferative-like disease caused by overexpression of Tlx1

i<em>n situ </em>in splenic stromal cells</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100242 1-D-W7-3-O/PPresentation: 6min,

Discussion: 2minNatsuko Imakita

Department of Immunology, Nara Medical

University, Nara, Japan

The contribution of histone methyltransferase Setdb2 in the pathogenesis of influenza

associated encephalopathy

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100243 3-F-W36-11-O/PPresentation: 7min,

Discussion: 3minTadashi Takeuchi

Laboratory for Intestinal Ecosystem, RIKEN

Center for Integrative Medical SciencesGut microbial metabolite acetate modulates affinity of IgA to maintain intestinal homeostasis

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100244 1-G-W13-13-P Poster Presentation Ueno YutaLaboratory of Molecular Biology and

Immunology, Department of Biological Science

and Technology, Tokyo University of Science

<strong>Two mesenchymal progenitor cell populations in the spleen defined by a novel

three-dimensional culture system</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100245 3-E-W35-10-P Poster Presentation Mizuki IshikawaAkita University, Graduate School of Engineering

Science, Laboratory for Molecular Cell

Physiology, Akita, Japan

Regulatory mechanism for intracellular sorting of Parm1 by NPxY motif.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100246 1-D-W7-6-O/PPresentation: 6min,

Discussion: 2minMasaaki Okamoto

Department of Immunology, Graduate School of

Medical Sciences, Kumamoto University,

Kumamoto, Japan

<strong>Circulating miR-451a in extracellular vesicles regulate innate immune cells

response to influenza A virus vaccine</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100247 3-H-W40-8-P Poster Presentation Izumi FujigakiDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

Suppression of mast cell-mediated allergic responses by valerate, butyrate, and niacin via

GPR109a.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100248 3-H-W40-9-P Poster Presentation Yuki NakamuraDepartment of Immunology, Faculty of Medicine,

University of Yamanashi, JapanRegulation of plasma histamine levels by the mast cell clock and its modulation by stress

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100249 1-A-W2-4-P Poster Presentation Ayumi FukuokaDepartment of Immunology, Hyogo College of

Medicine, Nishinomiya, Hyogo, JapanCystatin SN inhibits Japanese cedar pollen-induced allergic rhinitis in mice.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100250 1-E-W10-6-P Poster PresentationMasahiro

KitabatakeDepartment of Immunology, Nara Medical

University, Nara, Japan

<strong>CD8<sup>+</sup> T cells play a critical role for the murine model of immune

reconstitution inflammatory syndrome.</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

11 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100251 3-A-W26-2-O/PPresentation: 10min,

Discussion: 3minHikari Okamura

Division of Immune Regulation, Institute for

Genome Research, Tokushima UniversitySingle-cell analysis of autoreactive T cells under the control of PD-1

Dec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100252 3-C-W31-8-O/PPresentation: 8min,

Discussion: 3minRimpei MORITA

Department of Immunology, International

University of Health and Welfare, School of

Medicine, Narita, Japan

Clathrin heavy chain is an NLRP3 partner for NLRP3 inflammasome activationDec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100253 3-F-W37-7-O/PPresentation: 7min,

Discussion: 2minTakashi Kanaya

Laboratory for Intestinal Ecosystem, RIKEN

Center for Integrative Medical Sciences,

Yokohama, Kanagawa, Japan

IL-22 binding protein (IL-22BP) regulates the properties of follicle-associated epithelium

(FAE) to facilitate antigen uptake into Peyer&rsquo;s patches

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100254 1-G-W13-3-P Poster Presentation Takahiro NoguchiDepartment of Immunology and Cell Biology,

Osaka University Graduate School of Medicine,

Osaka, Japan

Dynamic analysis of hematopoietic stem cells in vivo by using intravital imaging techniquesDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100255 3-G-W39-5-O/PPresentation: 7min,

Discussion: 4minShinsuke Yasuda

Department of Rheumatology, Endocrinology and

Nephrology, Faculty of Medicine and Graduate

School of Medicine, Hokkaido University,

Sapporo, Japan

<strong>RasGRP-Ras-MAPK activation in </strong><strong>fibroblast-like synoviocytes

from patients with rheumatoid arthritis and inhibition of this pathway by Ras

translocation</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100256 2-I-W25-11-P Poster Presentation Seiki ShiraiLaboratory of Nano-design for Innovative Drug

Development, Graduate School of

Pharmaceutical Sciences, Osaka University

Development of dendritic cell-targeting peptides that induce antigen-specific immune

tolerance

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100257 2-A-W19-13-P Poster Presentation Airi MasakiDepartment of Plastic and Reconstructive

Surgery, Tohoku University school, Miyagi,

Japan

Critical role of interferon (IFN) - &gamma; in the skin wound healingDec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100258 2-A-W19-9-O/PPresentation: 7min,

Discussion: 3minEmi Furusawa

Department of Molecular Immunology , Tokyo

Medical and Dental University,Tokyo,Japan

Silencing of B7-DC/PD-L2 in the cutaneous dendritic cells using siRNA inhibits contact

allergy

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100259 1-F-W12-8-P Poster Presentation Kazuki Misato

Vaccine Creation Project, BIKEN Innovative

Vaccine Research Alliance Laboratories,

Research Institute for Microbial Diseases, Osaka

University

Development of a cancer vaccine by using dendritic cell-targeting peptideDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100260 3-C-W31-1-P Poster Presentation Yoshiyuki MiyazakiFaculty of Agriculture, Kyushu University,

Fukuoka, JapanThe induction of macrophage activation by a sulfated polysaccharide fucoidan

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100261 1-D-W8-11-P Poster PresentationTomotaka

Okamura

Tsukuba Primate Research Center, National

Institutes of Biomedical Innovation, Health and

Nutrition, Ibaraki Japan

Non-pathogenic AIDS virus carrying an adjuvant molecule induced strong cellular immunity

and long-term protective efficacy against pathogenic SHIV.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100262 3-I-W43-8-O/PPresentation: 7min,

Discussion: 3min

Mohammad A

SAYEM

Division of Cellular Signaling, Advanced Institute

of Medical Research, Keio University School of

Medicine, Tokyo, Japan

<strong>IL-8 has a negative role on tumor infiltrating CD8<sup>+</sup> T cells in various

cancers</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100263 1-D-W8-8-O/PPresentation: 6min,

Discussion: 2.5minTakuya Sueyoshi

Laboratory of Molecular Immunobiology,

Graduate School of Biological Sciences, Nara

Institute of Science and Technology (NAIST),

Nara, Japan

RNA-binding protein Hu antigen R (HuR) plays an important role in antiviral innate immune

responses via mRNA stabilization

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100264 2-A-W19-14-O/PPresentation: 7min,

Discussion: 3minMari Tenno

Department of Immune Regulation Research

Institute National Center for Global Health and

Medicine, Chiba, Japan

Disruption of Lnk increases severity of dextran sulfate sodium-induced acute colonic

inflammation

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100265 1-D-W7-12-P Poster Presentation Keiko NagataDivision of Molecular Pathology, Department of

Pathology, Faculty of Medicine, Tottori

University, Yonago, Japan

ImmunoglobulinG4 production is induced by reactivation of Epstein-Barr virus persistent in

B lymphocytes from Graves&rsquo; disease patients and controls

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100266 1-D-W7-8-O/PPresentation: 6min,

Discussion: 2minHaruna Okude

Laboratory of Molecular Immunobiology, Nara

Institute of Science and Technology, Nara, JapanInduction of cell death by imiquimod (R837) and its role in immune responses

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100267 3-A-W27-2-P Poster Presentation Akane HaraGraduate School of Systems Life Sciences,

Kyushu University, Fukuoka, JapanTheoretical study of relationship between allergy and intestinal microbiome.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100268 1-A-W1-10-O/PPresentation: 7min,

Discussion: 3min

Tomomitsu

Miyasaka

Division of Pathophysiology, Department of

Pharmaceutical Sciences, Faculty of

Pharmaceutical Sciences, Tohoku Medical and

Pharmaceutical University, Sendai, Japan

Possible involvement of CD103<sup>+</sup> dendritic cells in female-predominant Th2

priming in asthma

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100269 3-C-W31-10-P Poster Presentation Shiori Nakano

Department of Biological Science and

Technology, Faculty of Industrial Science and

Technology, Tokyo University of Science, Tokyo,

Japan

NR4A3 is involved in function of migratory DCs and activation of T cells in FITC-induced

contact hypersensitivity

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100270 1-B-W4-8-O/PPresentation: 7min,

Discussion: 2minKafi N. Ealey

Laboratory for Innate Immune Systems, RIKEN

IMS, Yokohama, Japan

Mechanisms for the regulation of adipose tissue expansion and remodeling by group 2

innate lymphoid cells

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100271 2-F-W22-3-P Poster Presentation Shinji FujimotoInstitute for Frontier Life and Medical Sciences,

Kyoto University, Kyoto, JapanD1V14(inverted), an oddly rearranged <em>Tcrb</em> in normal thymus

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100272 3-E-W34-15-P Poster PresentationMiyoko

Matsushima

Department of Pathophysiological Laboratory

Sciences, Nagoya University Graduate School of

Medicine, Nagoya, Japan

<strong>Deteriorated amount of IC capture without CD40 on B cells</strong>Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

12 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100273 3-F-W37-18-P Poster Presentation Yuki KanaiLaboratory of Nano-design for Innovative Drug

Development, Graduate School of

Pharmaceutical Sciences, Osaka University

Pulmonary vaccine against lung cancer developed using dendritic cell-targeting peptideDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100274 1-E-W10-3-O/PPresentation: 7min,

Discussion: 3minNaoto Nouchi

Division of Host Defense, Medical Institute of

Bioregulation, Kushu University, Fukuoka, Japan

IL-21 signaling drives differentiation of short-lived effector CD8<sup>+</sup>T cells from

early effector cells but does not inhibit exhaustion following <em>Mycobacterium

bovis</em> Bacillus Calmette-Gu&eacute;rin infection in mice

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100275 3-C-W31-3-P Poster Presentation Kazuko AtsumiDepartment of Pathophysiological Laboratory

Sciences, Nagoya University Graduate School of

Medicine, Nagoya, Japan

<strong>Analysis on signal pathway in pro-inflammatory response by diazinon</strong>Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100276 3-H-W40-10-P Poster Presentation Azusa KageyamaDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

Physiological significance of IL-10 produced by mucosal type mast cellsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100277 3-H-W41-5-P Poster Presentation Natsumi KikuchiDepartment of Biosciences, School of Science,

Kitasato University, Kanagawa, Japan

The roles of ILC3 and &gamma;&delta; T cells in the development of colitis of the model-

mice

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100278 1-I-W17-16-O/PPresentation: 7min,

Discussion: 3minNozomi Kuse

Center for AIDS Research, Kumamoto

University, Kumamoto, Japan

<strong>Effective priming of functional HIV-1-specific CD8<sup>+</sup> T Cells from

na&iuml;ve T cells using STING ligand</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100279 1-H-W16-2-O/PPresentation: 6min,

Discussion: 2minKoki Hirashima

Department of immunology, Graduate School of

Pharmaceutical Sciences, Hokkaido University

<strong>Tyk2 positively regulates <em>P. acnes</em>-induced acute

inflammation</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100280 2-A-W19-18-P Poster Presentation Atsushi NishidaShiga University of Medical Science, Otsu,

JapanExpression of Human Cathelicidin Peptide LL-37 in Inflammatory Bowel Disease

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100281 3-H-W40-11-P Poster Presentation Takahiro AraiDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

Transcriptional regulation of basophil-specific proteasesDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100282 2-A-W19-12-P Poster Presentation Ryuta MuromotoFaculty of Pharmaceutical Sciences, Hokkaido

University, Sapporo, Japan

Basal STAT3 activity maintained by TYK2 is required for IL-17-induced I&kappa;B-&zeta;

expression in keratinocytes

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100283 1-E-W10-5-O/PPresentation: 7min,

Discussion: 3minYusuke Tsujimura

Tsukuba Primate Research Center, National

Institutes of Biomedical Innovation, Health and

Nutrition, Ibaraki, Japan

The immune responses induced by BCG vaccination in the non-human primate TB modelDec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100284 3-H-W40-12-P Poster Presentation Megumi IwasakiDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

Generation of mutant mouse Fc&epsilon;RI&alpha;, which can be expressed as

&alpha;&gamma;<sub>2</sub> trimer and can bind to mouse IgE with high affinity

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100285 1-F-W12-4-O/PPresentation: 10min,

Discussion: 3minTakeshi Yamada

System Biology,Kanazawa

university,Kanazawa,Japan

<strong>Features of immune response induced </strong><strong>by

</strong><strong>Gemcitabine in </strong><strong>pancreatic ductal

adenocarcinoma</strong> <strong>model</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100286 3-B-W28-5-O/PPresentation: 11min,

Discussion: 2minHiroshi Watarai

Division of Stem Cell Cellomics, Institute of

Medical Science, University of Tokyo

<strong>A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9

Technology Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100287 2-I-W25-14-P Poster Presentation Miya Yoshino

Division of Immunology, Department of

Molecular and Cellular Biology, School of Life

Science, Faculty of Medicine, Tottori University,

Yonago , Japan

Measurement of the transport of skin self-antigens under inflammatory conditionsDec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100288 1-A-W2-5-P Poster Presentation Makoto MatsuiDepartment of Fundamental Biosciences, Shiga

University of Medical Science, Otsu, JapanRole of neutrophils in the nasal mucosa in a mouse model of allergic rhinitis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100289 3-C-W30-6-P Poster Presentation Hidetoshi NaraDepartment of Immunology, Yamagata University

Faculty of Medicine, Yamagata, Japan

Interleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive

state

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100290 3-C-W30-9-O/PPresentation: 7min,

Discussion: 3minRyo Okada

Dept. of integrated Biosciences, Grad. school of

frontier Sciences, The university of Tokyo,

Tokyo, Japan

Distribution of DCIR4 among various tissue-resident macrophagesDec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100291 1-A-W1-17-O/PPresentation: 7min,

Discussion: 3min

Kazuyuki

Nakagome

Department of Respiratory Medicine and Allergy

Center, Saitama Medical University, Saitama,

Japan

Elevated periostin concentrations in the bronchoalveolar lavage fluid of eosinophilic

pneumonia

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100292 1-A-W2-6-P Poster Presentation Daisuke NagakuboDepartment of Fundamental Biosciences, Shiga

University of Medical Science, Otsu, JapanInvolvement of CCL28 in the pathogenesis of allergic rhinitis in a mouse model

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100293 3-F-W36-14-O/PPresentation: 7min,

Discussion: 3minMayuri Tanaka

Laboratory of Adjuvant Innovation, Center for

Vaccine and Adjuvant Research, National

Institutes of Biomedical Innovation, Health and

Nutrition, Osaka, Japan

Essential role of CARD14 in murine experimental psoriasisDec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100294 1-I-W18-18-P Poster Presentation Hayato YabeResearch Institute for Frontier Medicine ,

Sapporo Medical University School of Medicine ,

Hokkaido , Japan

Regulatory mechanisms of the production of IgG4 in IgG4-related dacryoadenitis and

sialadenitis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

13 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100295 3-E-W34-16-P Poster Presentation Haruka SaitoDepartment of Biosciences, School of Science,

Kitasato University, Kanagawa, JapanRab13 prevents development of B cell lymphoma

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100297 1-I-W17-3-O/PPresentation: 7min,

Discussion: 3min

Ryutaro

IWABUCHIDepartment of Life Science and Medical

Bioscience, Waseda University, Tokyo, Japan

Human GM-CSF and Flt3-L induce reconstitution and maturation of human myeloid

dendritic cells in humanized mice

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100298 1-A-W1-1-O/PPresentation: 7min,

Discussion: 3minSho SHIBATA

Department of Immune Regulation, Tokyo

Medical and Dental University, Tokyo, Japan

Monocyte-derived macrophages in the lung contribute to the development of pulmonary

emphysema through MMP-12 production in a mouse model of COPD

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100299 3-D-W33-2-O/PPresentation: 7min,

Discussion: 3minIbuki Harada

Department of Immunology, Yokohama City

University Graduate School of Medicine,

Yokohama, Japan

<strong>Soluble factors produced by BCR-ABL-positive leukemic cells may compromise

antitumor immunity in chronic myeloid leukemia </strong>

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100300 1-A-W2-7-O/PPresentation: 7min,

Discussion: 3minMasaya Matsuda

Laboratory of Immunopharmacology, Faculty of

Pharmaceutical Sciences, Setsunan University,

Osaka, Japan

Effects of subcutaneous immunotherapy (SCIT) on regulatory T cells in pollinosis patientsDec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100301 1-A-W1-2-P Poster Presentation Minoru TakeuchiDept. of Animal Medical Science, Kyoto Sangyo

University, Kyoto, Japan

<strong>Effect of H</strong><strong>ot Water Extract from Agaricus Blazei Murill on

Lipopolysaccharide (LPS) -induced Lung Inflammation and the Immunological

Mechanism</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100302 1-G-W13-18-O/PPresentation: 6min,

Discussion: 2minArata Takeuchi

Department of Immunology, Graduate School of

Medical and Dental Sciences, Niigata University,

Niigata, Japan

Six different types of mesenchymal stromal cells provide the framework of multi-layered

subcompartments in lymph node

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100303 3-C-W31-11-P Poster Presentation Yuna UchidaDepartment of Biological Science and

Technology, Tokyo University of Science, Tokyo,

Japan

The role of NR4A3 in the gene expression and function of dendritic cellsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100304 1-E-W10-8-O/PPresentation: 7min,

Discussion: 3minDaiki Tanno

Department of Medical Microbiology, Mycology

and Immunology, Tohoku University Graduate

School of Medicine

Dectin-2-mediated signaling triggered by the cell wall structures of <em>Cryptococcus

neoformans</em>

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100305 3-H-W41-6-P Poster Presentation Shigeki SakaiDepartment of Medicine, Shiga University of

Medical Science, Shiga, Japan

Bortezomib suppresses the development of experimental colitis by inhibiting the activation of

NF-&kappa;B

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100306 2-A-W19-7-P Poster Presentation Kanae Niimi

International Education and Research Center for

Food and Agricultural Immunology, Graduate

School of Agricultural Science, Tohoku

University, Miyagi, Japan

Development of immune and microbial environments is independently regulated in the

mammary gland

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100307 3-G-W38-6-O/PPresentation: 7min,

Discussion: 4minYukiko Iwasaki

Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Japan

Plasma metabolomic analysis combined with transcriptome data has potential for

stratification of SLE patients

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100308 1-H-W16-5-O/PPresentation: 6min,

Discussion: 2minIppei Koshi

Department of Molecular and Cellular

Immunology, Shinshu University Graduate

School of Medicine

Branching cytokine signals for an effector function and cell survival via a discrete common

&beta; chain subregion in murine primary basophils

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100309 1-H-W15-8-O/PPresentation: 6min,

Discussion: 2minMizoguchi Izuru

Department of Immunoregulation, Institute of

Medical Science, Tokyo Medical University,

Tokyo, Japan

<strong>A Novel Role for Epstein-Barr Virus-Induced Gene 3 to Augment IL-23 Receptor

</strong><strong>&alpha;</strong> <strong>Protein Expression through A Lectin

Chaperone Calnexin </strong>

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100310 3-H-W41-7-P Poster Presentation Miki MatsuiDepartment of Pharmacology, Kyoto

Pharmaceutical University, Kyoto, Japan

The role of Ca<sup>2+</sup>-activated K<sup>+</sup> channel K<sub>Ca</sub>3.1 in

mesenteric lymph node CD4<sup>+ </sup>T cells of chemically-induced murine

inflammatory bowel disease model

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100311 1-A-W2-14-O/PPresentation: 7min,

Discussion: 3minKano Tanabe

Department of Medical Technology, Kumamoto

Health Science University, Kumamoto, JapanCaMKII regulates IgE class switch recombination via TRAF3 ubiquitination

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100312 1-G-W13-7-O/PPresentation: 6min,

Discussion: 2minJunichiro Takano

Laboratory for Immune Regeneration, RIKEN

Center for Integrative Medical Sciences,

Yokohama, Japan

<strong>Varinat PRC1.1 is required for specification of hematopoietic progenitor cells

toward B lymphoid lineage</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100313 1-D-W8-2-O/PPresentation: 6min,

Discussion: 2.5minHayato Murakoshi

Center for AIDS Research, Kumamoto

University, Kumamoto, Japan

Impact of a single escape mutation selected by HLA-A*24:02-restricted CD8<sup>+</sup>

T cells on HIV-1 control by HLA-B*35:01-restricted ones and T cell adaptation

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100314 3-G-W39-11-O/PPresentation: 7min,

Discussion: 4minSugimori Yusuke

Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

Comprehensive Flow Cytometric Analysis of Immune Cell Subsets in PBMCs from

Idiopathic Inflammatory Myopathy Patients

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100315 3-E-W34-5-O/PPresentation: 7min,

Discussion: 3minAkihiko Muto

Department of Biochemistry, Tohoku University

Graduate School of Medicine, Miyagi, JapanSingle-cell analysis of gene regulatory network in activated B cells

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100316 1-B-W4-12-P Poster Presentation Kyohei NishinoDepartment of Medicine, Shiga University of

Medical ScienceAnalysis of the role of autophay in dextran sodium sulfate (DSS) induced experimental colitis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100317 1-A-W2-15-P Poster Presentation Akira AwayaDermatology&amp;Epidemiology Research

Institute(DERI),Totsuka,Yokohama, Japan

Strategy for advance of melanocyte immunology from research on pollen-induced

diseases(PID) such as Kawasaki disease(KD) - Epidemiological study of KD(13): Statistical

analyses reveal epidemics of Influenza suppress or postpone KD onsets. Coadministration

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

14 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100318 1-H-W16-6-O/PPresentation: 6min,

Discussion: 2minYuki Hikichi

Laboratory for Innate Immune Systems, RIKEN

Center for Integrative Medical SciencesPost-transcriptional regulation of type 2 cytokine gene expression in ILC2

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100319 1-E-W9-13-P Poster Presentation Yoshihiko SugitaniDepartment of Medicine, Shiga University of

Medical Science, Otsu, JapanThe therapeutic effects of elemental diet and intestnal microbiota

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100320 1-I-W18-8-O/PPresentation: 7min,

Discussion: 3minMakoto Kuwahara

Department of Immunology, Graduate School of

Medicine, Ehime University, Ehime, JapanThe transcriptional repressor Bach2 regulates differentiation of pathogenic Th2 cells

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100321 1-A-W1-8-P Poster Presentation Tomohiro TamachiDepartment of Allergy and Clinical Immunology,

Graduate School of Medicine, Chiba University,

Chiba, Japan

A20 (<em>Tnfaip3</em>) expressed in T cells suppresses Th2 cell-mediated allergic airway

inflammation in mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100322 1-B-W3-6-O/PPresentation: 7min,

Discussion: 2minKohsuke Tsuchiya

Cancer Research Institute, Kanazawa University,

Kanazawa, Japan

Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D

(GSDMD)

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100323 3-F-W37-1-O/PPresentation: 7min,

Discussion: 2minHiroe Tetsu

Laboratory for innate Immune Systems, RIKEN,

IMS, JapanRole of group 2 innate lymphoid cells in the skin

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100324 1-G-W13-5-P Poster Presentation Yoshikazu HayashiInternational Research Center for Medical

Sciences, Kumamoto University, Kumamoto,

Japan

<strong>Impact of inflammatory stress on early hematopoiesis</strong>Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100325 1-B-W4-3-O/PPresentation: 7min,

Discussion: 2minAkiko Ishitani Nara Medical University, Kashihara, Nara, Japan

<em>The three faces of F: HLA-F as a ligand for KIRs, a cofactor in antigen presentation,

and a receptor on B cells and monocytes, combined in an immunoregulatory capacity

centered on the inflammatory response.</em>

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100326 3-F-W36-1-O/PPresentation: 7min,

Discussion: 3minAkira Nakajima

Center for Innovation in Immunoregulative

Technology and Therapeutics, Graduate School

of Medicine, Kyoto University

<strong>Mucus-associated functional factors in Bacteroidetes promotes inter-

phylum</strong><strong> symbiosis and colonic homeostasis</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100327 2-C-W21-7-O/PPresentation: 10min,

Discussion: 3minNgoc M Pham

Department of Surgery, Shiga University of

Medical Science, Otsu, Japan

Co-stimulation via OX40 signal <em>in vitro</em> to generate tumor antigen-specific CTLs

for adoptive cell transfer therapy

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100328 2-C-W21-6-O/PPresentation: 10min,

Discussion: 3minSatomi Okada

Department of Oncology, Nagasaki University

Graduate School of Biomedical Sciences,

Nagasaki, Japan

Development of TCR gene therapy with allogeneic &ldquo;Stealth T cells&rdquo; deficient

in endogenous TCR and HLA class I molecules

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100329 1-E-W10-10-P Poster Presentation Kotone KawamuraDepartment of Medical Microbiology, Mycology

and Immunology, Tohoku University Graduate

School of Medicine, Miyagi, japan

Activation of Dectin-2-mediated signaling by cryptococcal capsular polysaccharides:

Comparison between <em>Cryptococcus neoformans</em> and <em>C. gattii</em>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100330 3-H-W41-13-O/PPresentation: 7min,

Discussion: 3minYosuke Kurashima

Division of Mucosal Immunology, Department of

Microbiology and Immunology, The Institute of

Medical Science, The University of Tokyo, Tokyo,

Japan

<strong>Mesenchymal-myeloid cell interactions in renal microenvironment for pathological

fibrogenic machinery in kidney fibrosis</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100331 3-G-W38-4-O/PPresentation: 7min,

Discussion: 4minNatsumoto Bunki

Department of Allergy and Rheumatology,

Graduate School of Medicine, The University of

Tokyo, Japan

Pathophysiological analysis of systemic lupus erythematosus (SLE) using patient-derived

induced pluripotent stem cells

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100332 3-D-W33-16-P Poster PresentationYasumitsu

NishimuraDepartment of Hygiene, Kawasaki Medical

School

Secretory factors produced by immune cells upon exposure to asbestos facilitate

proliferation of mesothelial cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100333 1-I-W18-15-P Poster Presentation Akiho OniyamaMedical Microbiology, Mycology and

Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

Immunological analysis of the mechanism for higher virulence of <em>Cryptococcus

gattii</em> infection using a transgenic mouse expressing T cell antigen receptor for 98

kDa mannoprotein

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100334 3-B-W28-1-O/PPresentation: 11min,

Discussion: 2minShinya Hatano

Division of Host Defense, Medical Institute of

Bioregulation, Kyushu University, Fukuoka,

Japan.

Development of new monoclonal antibody specific for murine V&gamma;6 chainDec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100335 1-F-W12-11-P Poster Presentation Kaori Denda-NagaiDivision of Glycobiologics, Intractable Research

Center, Juntendo University Graduate School of

Medicine, Tokyo, Japan

Difference in humoral immune response after immunization with glycosylated MUC1

between C57BL/6 mice and MUC1 transgenic mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100336 1-G-W13-10-O/PPresentation: 6min,

Discussion: 2min

Masashi

Kanayama

Department of Immunology, Duke University

School of Medicine, Durham, North Carolina,

USA.

Balancing population sizes of myeloid and lymphoid cells by osteopontin isoformsDec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100337 3-D-W32-3-P Poster Presentation Taro KikuchiDepartment of Pathology, Sapporo Medical

University, Sapporo, JapanCTL responses against cancer with an MHC class I antigen-processing defect

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100338 3-F-W36-2-P Poster Presentation Junko NishioInstitute of Industrial Science, The University of

Tokyo, Tokyo, Japan

Surfactant protein D directly binds to gut bacteria and regulates microbiota composition for

intestinal homeostasis

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100339 1-A-W1-18-P Poster Presentation Shigeki KatohDepartment of Respiratory Medicine, Kawasaki

Medical School, Okayama, Japan

Possible role of IL-25 in eosinophilic lung inflammation in patients with eosinophilic

pneumonia

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

15 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100340 1-E-W9-11-O/PPresentation: 7min,

Discussion: 3min

Nobuhiro

NakamotoKeio University School of Medicine, Tokyo,

Japan

<strong>Integrated collaboration of intestinal microbiota induces bacterial translocation and

Th17 immune response in primary sclerosing cholangitis</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100341 3-C-W31-16-P Poster PresentationHiroyuki

Nakashima

Immunology and Microbiology, National Defense

Medical College, 3-2 Namiki Tokorozawa

Saitama, Japan

Liver sinusoidal endothelial cells and resident Kupffer cells are involved in cholesterol

metabolism in mice

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100342 1-C-W5-5-O/PPresentation: 7min,

Discussion: 3min

Fumihiro

YanagimuraDepartment of Neurology, Brain Research

Institute, Niigata University, Niigata, Japan

Differential dynamics of mucosal-associated invariant T cells in the blood and the CNS

lesions of patients with neuromyelitis optica

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100343 2-H-W24-5-P Poster Presentation Kenji IshiwataDepartment of Tropical Medicine, The Jikei

University School of Medicine, Tokyo, Japan

T cell-dependent long-lasting blockade of mucosal penetration by infective larvae of a

murine gastrointestinal nematode

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100344 3-F-W36-3-O/PPresentation: 7min,

Discussion: 3minEiji Miyauchi

Laboratory for Intestinal Ecosystem, IMS,

RIKEN, Yokohama, Japan

Mimicry peptides from gut commensals stimulate myelin-specific T cells and exacerbate

experimental autoimmune encephalomyelitis

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100345 1-F-W11-1-P Poster Presentation Matsuoka ShujiDepartment of Patology and Oncology Juntendo

University School of MedicineAnapocosis: Direct cell death of lymphoma cells induced by mAbs.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100346 1-D-W8-3-O/PPresentation: 6min,

Discussion: 2.5minChengcheng Zou

Center for AIDS research, Kumamoto University,

Kumamoto, Japan<strong>Conserved epitope-specific CTLs controlling HIV-1 replication</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100347 1-H-W15-1-O/PPresentation: 6min,

Discussion: 2minKentaro Asayama Dept of Immunology

<strong>A novel mouse model of spontaneous lung cancer caused by lung TGF-&beta;1

overexpression</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100348 2-B-W20-10-O/PPresentation: 7min,

Discussion: 3min

Masahiro

NakashimaImmunology and Microbiology, National Defense

Medical College, Tokorozawa, Japan

Repeated administrations of &alpha;-galactosylceramide slow the progression of lupus

nephritis in BWF1 mice

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100349 3-H-W41-2-P Poster Presentation Zhang BaoluoLaboratory of Pharmacotherapy of Life-Style

Related Diseases, Tohoku University

Role of histamine in IL-17 expression in Imiquimod-induced psoriasis-like inflammation

model

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100350 1-F-W12-5-P Poster Presentation Erica YADADepartment of Cancer Immunotherapy,

Kanagawa Cancer Center Research Institute,

Kanagawa, Japan

Next-generation sequencing analysis of gemcitabine (GEM) resistant mechanism using

patient-derived xenograft (PDX) model in pancreatic cancer

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100351 2-C-W21-13-P Poster Presentation Kento FujiwaraProject for Vaccine and Immune Regulation,

Graduate School of Pharmaceutical Sciences,

Osaka University

Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by

mRNA-EP for clinical research

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100352 1-F-W12-10-O/PPresentation: 10min,

Discussion: 3minYoshino Tanaka

Division of Immunobiology, Institute for Genetic

Medicine, Hokkaido University, Sapporo, JapanDying but not dead cancer cells exert the effect of cell-based cancer vaccine

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100353 1-B-W4-4-O/PPresentation: 7min,

Discussion: 2minToshiaki Totoki Dept. of Immunology

<strong>Overexpression of protein S exacerbates carbon tetrachloride-induced liver injury

and fibrosis</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100354 3-A-W26-6-P Poster Presentation Hirotaka KuwataSchool of dentistry, Showa University, Tokyo,

Japan

Microarray and gene co-expression analysis reveals that melatonin attenuates immune

responses and modulates actin rearrangement in macrophages.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100355 1-B-W4-15-P Poster PresentationYasuharu

Watanabe

Department of Immunobiology and

Pharmacological Genetics, Graduate School of

Medicine and Pharmaceutical Science for

Research, University of Toyama, Toyama,

Japan

<strong>The interaction of neutrophils with adipocytes plays a key role in the infiltration of

macrophage into the adipose tissue</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100356 1-A-W1-11-O/PPresentation: 7min,

Discussion: 3minKentaro Fujiwara Dept. of Immunology

<strong>M1 macrophages mediate attenuation of bronchial asthma by matrix-

metalloproteinase-2</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room A

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100357 1-D-W7-13-P Poster Presentation Yoshiko MurakataTsukuba Primate Research Center, National

Institute of Biomedical Innovation, Ibaraki, Japan

<strong>Studies of incomplete control of Epstein-Barr virus infection by using cynomolgus

macaques model.</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100358 1-F-W12-9-P Poster Presentation Shunsuke Takese

Department of Pharmacokinetics and

Biopharmaceutics, Institute of Biomedical

Sciences, Tokushima University, Tokushima,

Japan

The combined effect of liposomal oxaliplatin with cancer vaccine on anticancer therapy.Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100359 1-E-W9-8-P Poster Presentation Matsui KatsuhikoDepartment of Microbial Science and Host

Defense, Meiji Pharmaceutical University, Tokyo,

Japan

<strong>Mast cells stimulated with peptidoglycan from <em>Staphylococcus aureus</em>

enhance the development of Th1 cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100360 3-H-W40-13-P Poster Presentation Shotaro NakajimaDept. Immunology, Univ. Yamanashi,

Yamanashi, JapanResveratrol inhibits IL-33-mediated mast cell activation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100361 2-H-W24-3-P Poster Presentation Takeshi OnoDepartment of Global Infectious Diseases and

Tropical Medicine, National Defense Medical

College

CD8<sup>+</sup> T cell immune responses during the <em>Plasmodium berghei</em>

ANKA blood stage infection

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

16 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100362 3-D-W32-4-O/PPresentation: 7min,

Discussion: 3minYoh Ohnuki

Department of Immunology, Graduate School of

Medicine and Pharmaceutical Sciences,

University of Toyama, 2630 Sugitani, Toyama

930-0194, Japan

The model of antigen detection system using yeast surface display libraryDec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100363 3-H-W40-1-O/PPresentation: 7min,

Discussion: 3minJing Wang

Institute of Enzyme Research, Tokushima

University, Tokushima, JapanTracking the fate of neutrophils in sterile injury using photoactivation and intravital imaging

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100364 3-F-W36-15-P Poster Presentation Noriko SatoDept. of Plastic and Reconstructive surgery,

Tohoku Univ.Effect of Mincle deficiency on the wound healing process in skin

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100365 1-F-W12-1-O/PPresentation: 10min,

Discussion: 3minHirohito Ishigaki

Department of Pathology, Shiga University of

Medical Science, Otsu, Japan,

<strong>The hemoperfusion column removing LAP positive cells activates the tumor-

specific immunity in a cynomolgus monkey</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room F

Immune responses in cacer

immunotherapy

Toshihiko

TorigoeKenichiro Seino

100366 2-G-W23-5-O/PPresentation: 10min,

Discussion: 3minSumika Toyama

Institute for Environmental and Gender Specific

Medicine, Juntendo University Graduate School

of Medicine, Chiba, Japan

Regulatory T cells control skin inflammation in atopic dermatitis model mouseDec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100367 1-G-W13-17-O/PPresentation: 6min,

Discussion: 2minKazuki Sato

Department of Immunology, Faculty of Medicine,

University of Tsukuba, Ibaraki, Japan

Marginal reticular cells act as a non-professional phagocyte for clearance of apoptotic B

cells

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100368 2-I-W25-2-O/PPresentation: 7min,

Discussion: 3minAlessandro Nasti

System Biology, Kanazawa University,

Kanazawa, Japan

<strong>The CD45<sup>+</sup> subset in murine uncultured adipose tissue-derived

stromal cells features immune-inhibitory M2 macrophage-like cells</strong><strong>

contributable for </strong><strong>therapeutics </strong><strong>of

</strong><strong>acute h

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100369 3-C-W30-10-O/PPresentation: 7min,

Discussion: 3minNaoki Matsumoto

Graduate School of Frontier Sciences, the

University of Tokyo, Chiba, JapanCo-expression of DCIR3 and DCIR4 on monocytes

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100370 3-H-W40-14-O/PPresentation: 7min,

Discussion: 3min

Wakabayashi

SeiichiroDermatology, Chiba University, Chiba, Japan

Homeostasis of peripheral macrophages are controlled by mast cells <em>via</em> newly

identified c-Kit<sup>+</sup>CD11b<sup>+</sup> tissue-resident macrophage progenitor

cells

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100371 1-F-W11-8-O/PPresentation: 9min,

Discussion: 2minAlok Kumar

Department of Immunology and Genomic

Medicine, Graduate School of Medicine, Kyoto

University, Kyoto, Japan

<strong>Indicators of mitochondrial activation in T cells could be a biomarker to predict the

PD-1 blockade therapeutic efficacy.</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100372 1-E-W9-1-O/PPresentation: 7min,

Discussion: 3min

Takayuki

MatsumuraDepartment of Immunology, National Institute of

Infectious Diseases, Tokyo, Japan

<strong>Balance of pro- and anti-inflammatory cytokines in immature myeloid cells involved

in outcome of severe invasive group A <em>Streptococcus</em> infections</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100373 1-F-W11-6-P Poster Presentation Shota KajiyamaKobayashi Pharmaceutical Co., Ltd., Osaka,

Japan

Investigation of the effect of a combination of immune checkpoint inhibitor and Lentinula

Edodes Mycelia (L.E.M.) extract on antitumor response in CT26 colon carcinoma-bearing

mice.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100374 3-E-W35-8-O/PPresentation: 7min,

Discussion: 3minKatsuki Usami

International Education and Research Center for

Food and Agricultural Immunology, Graduate

School of Agricultural Science, Tohoku

University, Miyagi, Japan

Important role of the immunological network between large intestine and mammary gland in

breastfeeding

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100375 1-F-W11-7-O/PPresentation: 9min,

Discussion: 2minNobuo Tsukamoto

Division of cellular Signaling, Institute for

Advanced Medical Research, Keio University

School of Medicine, Tokyo, Japan

Berberine augments tumor antigen specific T cells <em>in vivo</em> through metabolic

remodeling in CD8<sup>+</sup> T cells in tumors and lymph nodes

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100376 1-I-W18-13-P Poster Presentation Shojiro IkezakiSection of Infection Biology, Department of

Functional Bioscience, Fukuoka Dental Collage.

A novel alternative splicing of T-cell signaling molecule modulates TCR-mediated responses

in Th2 cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100377 2-F-W22-6-P Poster Presentation Haruki KatsumataDept of Urology, Tokyo Women’s Medical Univ,

Tokyo, Japan.

In Vitro Stimulation with &alpha;-galactosylceramide Expands

CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>&minus;</sup> Regulatory T Cell

Precursors in Murine Thymocytes

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100378 1-E-W10-9-P Poster Presentation Yuki KITAIMedical Microbiology, Mycology and

immunology, Tohoku University Graduate School

of Medicine

<strong>Involvement of Dectin-2 in the recognition and phagocytosis of

</strong><em><strong>Cryptococcus neoformans </strong></em><strong>by dendritic

cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100379 1-B-W3-12-P Poster Presentation Rina SugimotoDepartment of Cell Biological Science, Graduate

School of Life Science, Hokkaido University,

Sapporo, Japan

Evaluation system for receptor expression and function in the intestinal stem cell nicheDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100380 3-D-W33-11-P Poster Presentation Asuka MiyamotoDepartment of Molecular Life Science, Tokai

University School of Medicine, Isehara,

Kanagawa, Japan

Production of specific IgG against HER2 peptide is decreased in NOG-IL4-Tg mice

transplanted with breast cancer patients PBMC

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100381 2-A-W19-3-O/PPresentation: 7min,

Discussion: 3minDaisuke Takahashi

Keio University Faculty of Pharmacy, Tokyo,

JapanMicrobial fermentation product butyrate Ameliorates Autoimmune Arthritis.

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100382 1-B-W3-15-P Poster Presentation Takumi AdachiDepartment of Immunology, Hyogo College of

Medicine, Nishinomiya, Hyogo, Japan

Purification and characterization of a unique DAMP of a potent inducer of IL-33 expression

in non-hematopoietic cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100383 1-E-W9-4-O/PPresentation: 7min,

Discussion: 3minRin Yokoyama

Medical Microbiology, Mycology and

Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

<strong>Dectin-2-mediated signaling triggered by serotype 3 <em>Streptococcus

pneumoniae </em>and its contribution to host immune response</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

17 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100384 1-C-W6-7-O/PPresentation: 7min,

Discussion: 3minKunihiro Otsuka

Department of Oral Molecular Pathology,

Institute of Biomedical Science, Tokushima

University Graduate School, Tokushima, Japan

Analysis of follicular helper T cells in a mouse model for Sj&ouml;gren&rsquo;s syndromeDec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100385 3-H-W41-9-O/PPresentation: 7min,

Discussion: 3minKota Nishihama

Mie University Graduated School of Medicine,

Diabetes, Metabolism and Endocrinology, Tsu,

Japan

Anti-diabetic effect of matrix metalloproteinase-2 and its correlation with protein S in

diabetes

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100386 3-E-W34-3-O/PPresentation: 7min,

Discussion: 3minHitomi Sakatani

Nara Institute of Science and Technology, Nara,

JapanNovel compounds that induce specifically class switching to IgA

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100387 3-D-W33-7-P Poster Presentation Mikako NishidaDepartment of Immunology, Graduate School of

Medicine, Dentistry and Pharmaceutical

Sciences, Okayama University, Okayama, Japan

Anti-oxidative stress response is involved in Metformin-induced anti-tumor immunityDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100388 3-F-W37-12-O/PPresentation: 7min,

Discussion: 2minMotoyoshi Nagai

Graduate School of Pharmaceutical Science,

Keio University, Tokyo, Japan

Nutritional signals are essential for the regulation of cell dynamics and mucosal immune

response in GALT

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100389 3-A-W27-7-O/PPresentation: 10min,

Discussion: 3minYoshiaki Yasumizu

Faculty of Medicine, Osaka University, Osaka,

Japan

Significance of the regulatory T cell-specific epigenetics in autoimmune disease

susceptibility

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100390 3-H-W40-2-P Poster Presentation Shin MorisawaDepartment of Immunology, Kitasato University

Graduate School of Medical Sciences,

Sagamihara, Japan.

Quantitative analysis of Neutrophil extracellular traps (NETs) in lupus prone mouse using

novel methods

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100391 3-I-W42-6-O/PPresentation: 7min,

Discussion: 3minTakayuki Imanishi

RIKEN Center for Integrative Medical Sciences

(IMS) Laboratory for Cell Signaling, Yokohama,

Japan

TCR-signals control STING-mediated type 1 IFN responses in T cellsDec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100392 3-B-W28-12-O/PPresentation: 11min,

Discussion: 2minAsako Chiba

Department of Immunology, Juntendo University,

Tokyo, JapanMAIT cells exacerbate the disease course of oxazolone colitis.

Dec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100393 1-F-W11-12-O/PPresentation: 9min,

Discussion: 2minNanumi Han

Division of Immunobiology, Institute for Genetic

Medicine, Hokkaido University, Sapporo, Japan

<strong>Identification of factors that affect myeloid cells in immunotherapeutic-resistant

tumors</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100394 2-G-W23-18-P Poster Presentation Hee Soon ShinKorea Food Research Institute, Sungnam-si,

Korea

Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse

model of food allergy

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100395 3-B-W28-4-O/PPresentation: 11min,

Discussion: 2minEri Ishikawa

Department of Molecular Immunology, Research

Institute for Microbial Diseases, Osaka

University, Osaka, Japan

A critical role of protein kinase D in NKT cell developmentDec. 14

(Thu.), 201712:50-14:10 Room B

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100396 3-F-W37-2-P Poster Presentation Weng Sheng KongDepartment of Immunology, Graduate School of

Biomedical and Health Sciences, Hiroshima

University, japan

Analysis of gut and skin inflammation in the pathogenesis of atopic dermatitisDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100397 1-H-W15-15-P Poster Presentation Hiroki TanakaWorld Premier Institute Immunology Frontier

Research Center (WPI-IFReC), Osaka

University, Osaka, Japan

Regnase-1 phosphorylation induced by proinflammatory cytokines controls stability of its

target mRNAs.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100398 1-I-W17-17-P Poster Presentation Kaori HayashiDepartment of Obstetrics and Gynecology, Shiga

University of Medical Science, Otsu, Japan

Efficacy of spontaneous occurring endometriosis by extracorporeal circulation in

cynomolgus monkey

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100399 3-H-W41-3-P Poster Presentation Shoichiro MiyatakeDepartment of Immunology, Graduate School of

Environmental Health Sciences, Azabu

University, Kanagawa, Japan

Dermatitis developed in GATA3 mutant miceDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100400 2-G-W23-6-O/PPresentation: 10min,

Discussion: 3min

Kazumasa

KanemaruDepartment of Immunology, Faculty of Medicine,

University of Tsukuba, Ibaraki, Japan<strong>Clec10a suppresses house dust mite-induced dermatitis</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100401 3-H-W41-10-P Poster Presentation Taro YasumaDepartment of Immunology, Mie University

Graduate School of Medicine

Protein S inhibits apoptosis of pancreatic &beta; cells by regulating BIRC3 expression and

AKT signaling

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100402 3-C-W30-12-O/PPresentation: 7min,

Discussion: 3minShojiro Haji

Department of Molecular Immunology, Division

of Host Defense, Research Institute for Microbial

Diseases, Osaka University, Osaka, Japan

Recognition of lipids from <em>Helicobacter pylori</em> by dendritic cell immunoactivating

receptor (DCAR).

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100403 1-I-W17-18-O/PPresentation: 7min,

Discussion: 3minIyoda Tomonori

RIKEN Center for Integrative Medical Sciences,

Yokohama, Japan

Improvement of NK cell function against multiple myeloma cells by an adjunctive effect of

activated invariant natural killer T (NKT) cells

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100404 3-D-W33-3-O/PPresentation: 7min,

Discussion: 3min

Hirotake

Tsukamoto

Department of Immunology, Graduate School of

Medical Sciences, Kumamoto University,

Kumamoto, Japan

<strong>Combined blockade of IL-6 and PD-L1 signals breaks a mutual regulation of their

immunosuppressive effects on anti-tumor immunity</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100405 1-C-W5-3-O/PPresentation: 7min,

Discussion: 3minYouwei Lin

Department of Immunology, National Institute of

Neuroscience, National Center of Neurology and

Psychiatry

Inverse vaccination by superior dominant peptide inhibit the reactivity to disease-associated

antigens and promote tissue-repair capacity in stabilized antigen-specific regulatory T cells

to control of relapsing and progression of animal model of multiple

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

18 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100406 3-E-W35-9-O/PPresentation: 7min,

Discussion: 3minHirohiko Ono

National Center of Neurology and Psychiatry

National Institute of Neuroscience, Department

of Immunology, Tokyo, Japan

Dysregulated B cells in Myalgic encephalomyelitis/Chronic Fatigue SyndromeDec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100407 2-B-W20-5-P Poster Presentation Hiroyuki NishimuraToin Human Science and Technology Center,

Toin University of Yokohama, Yokohama Japan

Epistatic interaction between <em>fcgr2b</em> and <em>Slam</em> family genes in

susceptibility to defective foreign protein-induced tolerance

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100408 3-A-W26-7-P Poster Presentation Yuya YoshidaDepartment of Pathological Biochemistry,

Faculty of Pharmaceutical Sciences, Setsunan

University, Osaka, Japan

Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus

pathogenic antigen in a glucose-6-phosphate isomerase peptide-induced arthritis mouse

model: the fourth report

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100409 1-F-W11-11-O/PPresentation: 9min,

Discussion: 2minChang-Yu Chen

Department of Molecular Preventive Medicine,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

<strong>Low-dose HMGN1 synergistically enhances anti-tumor immunity in CD4 depleting

antibody-treated mice</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100410 3-E-W34-11-P Poster Presentation Ryouma Totera Narashino, Chiba , Japan Cultured B cells and Immune globlulin gene expression.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100411 1-H-W15-3-O/PPresentation: 6min,

Discussion: 2minWooseok Seo

RIKEN IMS Center for Integrative Medical

Sciences,Yokohama, JapanRegulation of CCL5 expression by Runx complexes and two stage-specific enhancers

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100412 1-I-W17-4-P Poster Presentation Yusuke OhnoDepartment of Molecular Life Science, Tokai

University School of Medicine, Isehara, Japan<strong>Pregnant humanized mouse as a model of human pregnant immunity</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100413 1-I-W18-10-O/PPresentation: 7min,

Discussion: 3minMasaki Tajima

Laboratory of Host Defenses, NIAID, NIH,

Maryland, USA

<strong>IL-10-Producing Tr2 cells Induced by mTOR/CEBP&beta; Signaling Regulate

Hyphal <em>C. albicans</em> Kidney Infection</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100414 3-I-W43-17-O/PPresentation: 7min,

Discussion: 3min

Harumichi

Iahigame

Laboratory for Tissue Dynamics, RIKEN Center

for Integrative Medical Sciences, Kanagawa,

Japan

<strong>Developmental plasticity of KLRG1<sup>+</sup> effector CD8<sup>+</sup> T

cells promotes protective immunity</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100415 3-H-W41-11-O/PPresentation: 7min,

Discussion: 3minAtsuro Takeshita

Diabetes, Metabolism and Endocrinology, Mie

University Graduate School of Medicine, Tsu,

Japan

Protein S reduces the progression of diabetic nephropathy in miceDec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100416 3-C-W31-13-P Poster Presentation Natsuno HamaDepartment of Biosciences, School of Science,

Kitasato University, Kanagawa, JapanRap1 plays central role in adhesion and migration of DCs.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100417 3-I-W42-11-O/PPresentation: 7min,

Discussion: 3minTsuyoshi Sato

Department of Biosciences, School of Science,

Kitasato University, kanagawa, JapanT cell specific Rap1-deficient mice develop spontaneous colitis

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100418 3-A-W27-3-P Poster Presentation Yuji KashiwakuraDepartment of Immunology, Dokkyo Medical

University School of Medicine, Mibu, Tochigi,

Japan

Heparin induces regulatory T cells by IL-2 production in miceDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100419 2-A-W19-10-P Poster PresentationDaisuke

TAKABAYASHINarashino, Chiba , Japan Roles of MGL2 positive DC and Basophil on type 2 Contact Hypersensitivity model mice.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallMucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100420 3-D-W33-14-P Poster Presentation Yuetsu TanakaDepartment of Immunology, Graduate School of

Medicine, University of the Ryukyus, Okinawa,

Japan

The importance of fixation/permeablization methods for flow cyotometric detection of human

FoxP3 antigen as examined using human Treg and non-Treg cell lines transformed by

HTLV-I

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100421 3-D-W32-10-O/PPresentation: 7min,

Discussion: 3minRisa Fujii

Department of Anatomy and Embryology, Faculty

of medicine, University of Tsukuba, Tsukuba,

Japan

<strong>MafB inhibits tumor growth through regulating</strong> <strong>Tumor-

Associated &ndash;Macrophages in spleen</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100422 1-E-W9-10-P Poster Presentation Hiromi MiyazakiDivision of Traumatology, Research Institute,

National Defense Medical College, Tokorozawa,

Japan

Coenzyme Q10 supplementation protects against methicillin-resistant Staphylococcus

aureus infection in burn-injured mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100423 2-F-W22-9-P Poster Presentation Kana MisawaKitasato University School of Medicine,

Sagamihara, Japan

Analyses of genes expressed in the cortical thymic epithelial cells in immuno-compromised,

<em>alymphoplasia</em> mice

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100424 3-A-W27-5-P Poster Presentation Hidefumi KojimaDepartment of Immunology, Dokkyo Medical

University School of Medicine, Tochigi, JapanFatty acids affect regulatory T cell metabolism and function during immune responses.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100425 2-H-W24-6-P Poster Presentation Koubun YasudaDepartment of Immunology, Hyogo College of

Medicine

IL-33-dependent resistance of <em>Strongyloides venezuelensis</em>-experienced mice

against <em>Nippostrongylus brasiliensis</em> infection

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100426 3-E-W35-1-O/PPresentation: 7min,

Discussion: 3minKatsuya Sato

Department of Molecular Pathobiochemistry,

Gifu University School of Medicine, Gifu, Japan

Analysis of cis-regulatory elements involved in the regulation of expression of

<em>Aicda</em>

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100427 3-B-W29-11-P Poster PresentationDaichi

KOBAYASHI

Chiba Institute of Technology, Faculty of

Engineering, Department of Life and

Environmental Sciences. Narashino, Chiba,

Japan

The effect of ILC3 regulated by glial cells in gut in inflammatory condition.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

19 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100428 3-H-W40-23-P Poster Presentation Toshihisa NAGAOThe Department of Immune Regulation, Tokyo

Medical and Dental University, Tokyo, Japan

Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-

mediated allergic inflammation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100429 3-E-W34-12-P Poster Presentation Ryouma KOTERA

Chiba Institute of Technology, Graduate School

of Engineering, Department of Life and

Environmental Sciences, Tsudanuma, Chiba

,Japan

T cell dependent and independent regulation on immune globulin gene expressions in vitro

B cell differentiation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100430 2-B-W20-8-P Poster Presentation Akira IizukaDepartment of Internal Medicine, Faculty of

Medicine, University of Tsukuba, Ibaraki, JapanThe regulatory role of Allergin-1 in autoantibody production

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100431 1-D-W7-2-O/PPresentation: 6min,

Discussion: 2minHiroshi Ueki

Division of Virology, Department of Microbiology

and Immunology, Institute of Medical Science,

University of Tokyo

Visualization of immune responses to influenza virus in mouse lung by using two-photon

microscopy

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100432 3-D-W32-17-P Poster Presentation Yui EzakiDepartment of Immunology,Kurume University

School of Medicine

<strong>Chitinase 3-like 1</strong><strong> (CHI3L1/YKL-40)</strong><strong> induces

carcinogenic changes of epithelial cells by promoting cell survival and proliferation under in

vitro and in vivo conditions</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100433 3-H-W41-1-O/PPresentation: 7min,

Discussion: 3minTakumi Itoh

Department of Therapy Development and

Innovation for Immune disorders and Cancers,

Graduate School of Medicine, Juntendo

University, Tokyo, Japan

IL-26 facilitates angiogenesis and skin inflammation via inducing FGF2 production in a

murine model of imiquimod-induced psoriasis

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100434 3-H-W40-15-O/PPresentation: 7min,

Discussion: 3minYuta Kogure

Division of Mucosal Immunology, Department of

Microbiology and Immunology, The Institute of

Medical Science, The University of Tokyo, Tokyo,

Japan

Mesenchymal-mediated skin-specific regulatory system for the control of tissue resident

mast cells

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100435 3-B-W29-6-P Poster PresentationTsutomu

YanagibashiToyama Prefectural Institute for Pharmaceutical

Research, Toyama, Japan

IL-5-producing ILC2s in the large intestine contribute to T cell-independent IgA production

through the regulation of eosinophil homeostasis

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100436 3-B-W29-12-P Poster Presentation Shinichiro SawaInstitute for Genetic Medicine, Hokkaido

University, Sapporo, JapanDevelopment of novel mouse models lacking for group 3 innate lymphoid cells.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100437 3-H-W41-16-O/PPresentation: 7min,

Discussion: 3minTomonori Kaifu

Department of Immunology, Tohoku Medical and

Pharmaceutical UniversityDCIR negatively regulates osteoclastogenesis by binding to a novel endogenous ligand

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100438 1-G-W13-20-P Poster Presentation Yasuhiro KandaDepartment of Immunology and Medical Zoology,

Niigata University Graduate School of Medical

and Dectal sciences

Live imaging of the allogeneic T cell elimination in secondary lymphoid organsDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100439 3-I-W42-13-P Poster Presentation Kenta IwasakiDepartment of Kidney Disease and Transplant

Immunology, Aichi Medical University School of

Medicine, Aichi, Japan

Differential response of allo-reactive CD4 T-cells against HLA class II expressed on

endothelial cells in the presence of HLA and ABO antibody.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100440 1-I-W17-5-P Poster Presentation Asami HanazawaCentral Institute for Experimental Animals,

Kawasaki, Japan

<strong>NOG human M-CSF transgenic mice enhance differentiation and maturation of

human monocytes and macrophages</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100441 1-A-W1-6-P Poster Presentation Jung Yeon Hong

Department of Pediatrics and Institute of Allergy,

Brain Korea 21 PLUS Project for Medical

Science, Yonsei University College of Medicine,

Seoul, Korea

<strong>Chitotriosidase Regulation of Allergen-induced Airway Inflammation Airways

Hyperresponsiveness and Foxp3<sup>+</sup> Treg Cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100442 3-A-W27-6-P Poster Presentation Chihiro OhashiKitasato University School of Medicine,

Sagamihara Japan

Spontaneous accumulation of myeloid-derived suppressor cell (MDSC)-like

CD11b<sup>+</sup>/Gr-1<sup>+</sup> cells in the periphery of NF-&kappa;B-inducing

kinase (NIK) mutant mice.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100443 2-C-W21-1-O/PPresentation: 10min,

Discussion: 3minKiyomi SHITAOKA

Department of Innovative Cancer

Immunotherapy, Graduate School of Medicine

and Pharmaceutical Sciences, University of

Toyama, Toyama City, Japan

Majority of tumor infiltrating lymphocytes in B16F10 melanoma recognized tumor-

associated antigens, but not melanoma-associated antigens or neoantigens.

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100444 1-I-W18-11-P Poster Presentation Tomo TakebePharmaceutical Sciences, Tokyo University of

Science, Chiba, JapanA novel mouse model for tracking the fate of follicular helper T cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100445 1-I-W17-6-P Poster Presentation Ikumi KatanoCentral Institute for Experimental Animals,

Kawasaki, Japan

Human macrophages which developed into NOG-human GM-CSF/IL-3 Tg mice after

hematopoietic stem cells phagocytosed mouse erythrocytes and induced serious anemia.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100446 3-B-W29-7-O/PPresentation: 11min,

Discussion: 2minNaoko Satoh

Laboratory for Intestinal Ecosystem, Center for

Integrative Medical Science, RIKEN

Identification of an ILC2 population in the stomach which responds to commensal and

pathogenic bacteria

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100447 2-F-W22-15-P Poster Presentation Fu Lian LYU

Department of Immunology, Graduate School of

Medicine and Pharmaceutical Sciences,

University of Toyama, 2630 Sugitani, Toyama

930-0194, Japan

A novel method to produce high amounts of recombinant MHC/peptide complexes for

isolation of antigen-specific human TCRs

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100448 3-B-W29-2-P Poster Presentation Koga SatoshiLaboratory for Innate Immune Systems, RIKEN

IMS, Kanagawa, Japan

Developmental trajectory of tissue-resident ILC2 from primary lymphoid organs to the

peripheral microenvironment

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100449 3-I-W42-7-P Poster Presentation OGAWA ShuheiDivision of Immunobiology, Research Institute for

Biomedical Sciences, Tokyo University of

Science

The regulation of CD28 tyrosine phosphorylation and the function of CD28-mediated

costimulation.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

20 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100450 1-A-W1-7-P Poster Presentation Mi Na Kim

Department of Pediatrics and Institute of Allergy,

Brain Korea 21 PLUS Project for Medical

science, Yonsei University College of Medicine,

Seoul, Republic of Korea

ALCAM on dendritic cell contributes Th2 response in allergic airway inflammationDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100451 2-G-W23-7-P Poster Presentation Ken IgawaDepartment of Dermatology, Dokkyo Medical

University, Mibu, Japan

Therapeutic effect of the improved version Stat6 decoy ODN containing ointment utilizing

new technology ILTS&reg; on murine skin inflammatory responses.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100452 3-F-W37-17-O/PPresentation: 7min,

Discussion: 2minHideki Asanuma

National Institute of Infectious Diseases, Tokyo,

JAPAN

<strong>Essential roles for protective SIgA Abs induced by nasal G9.1 combined influenza

VLP vaccine</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100453 3-D-W32-13-P Poster Presentation Yui KurokiReserch Institute for Biomedical Sciences,Tokyo

University of Science

Analysis of antigen prosenting cells that inducec CD8+ CD11c+ T cells in tumor

microenviroment

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100454 1-D-W8-12-P Poster PresentationWarunthorn

Monwan

Laboratry of Molecular Immunobiology, Graduate

School of Biological Sciences, Nara Institute of

Science and Technology, Nara, Japan

Characterization of Nucleoporin (Nup) genes that mediate antimicrobial innate immune

responses

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100455 2-G-W23-8-P Poster Presentation Sekiguchi KotaLaboratory of Microbiology and Immunology,

School of Pharmaceutical Sciences, University of

Shizuoka, Shizuoka, Japan

A triacylglycerol, tributyrin, has an adjuvant effect in a mouse contact hypersensitivity modelDec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100456 3-H-W40-22-O/PPresentation: 7min,

Discussion: 3minTomoyuki Bando

Ono pharmaceutical co., ltd. Exploratory

Research Laboratories, Osaka, JAPAN

<strong>Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells

and basophils</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100457 3-F-W36-12-P Poster Presentation Naoya TsugawaDepartment of Gastroenterology, Graduate

School of Medical Science, Tokyo Medical and

Dental University, Tokyo, Japan

<strong>Verification of immunoglobulin A regulation of mucosal microflora and

homeostasis</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100458 1-E-W10-12-O/PPresentation: 7min,

Discussion: 3minKeigo Ueno

Department of Chemotherapy and Mycoses,

National Institute of Infectious Diseases, Tokyo,

Japan

Dendritic cell-based vaccination induces lung resident memory Th17 cells that ameliorate

pulmonary infection with highly virulent <em>Cryptococcus gattii</em>

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100459 2-I-W25-6-O/PPresentation: 7min,

Discussion: 3min

Yoshimitsu

Nakanishi

Department of Respiratory Medicine and Clinical

Immunology, Graduate School of medicine,

Osaka University, Osaka, Japan

Sema6D prevents excess inflammation during high-fat feeding by controlling mitochondrial

metabolism.

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100460 3-A-W27-8-P Poster Presentation Sayuri FukushimaGraduate School of Food, Agricultural and

Environmental Sciences, Miyagi University,

Miyagi, Japan

Specific expression of C3 components, C3b, iC3b with increase of IL-10 and TGF-&beta; in

uterus&rsquo;s endometrium of mouse for the latter pregnant period

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100461 3-I-W42-12-O/PPresentation: 7min,

Discussion: 3minNaoyuki Kondo

Kansai medical university, Hirakata, Osaka,

JapanNDR1 acts as a molecular hub for the organization of immunological synapse

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100462 3-D-W33-4-O/PPresentation: 7min,

Discussion: 3minHaruka Wada

Division of Immunobiology, Institute for Genetic

Medicine, Hokkaido UniversityTumor initiating cell in immunocompetent animal defined by immunological features

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100463 1-H-W16-15-P Poster Presentation Riyoko TamaiDepartment of Oral Medical Science, Ohu

University School of Dentistry, Fukushima,

Japan

Alendronate induces caspases-independent cell death via NLRP3 and ASCDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100464 3-F-W36-13-P Poster Presentation Takashi NagaishiDepartment of Gastroenteroogy, Graduate

School of Medical Science, Tokyo Medical and

Dental University

<strong><em>XXX</em></strong>Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100465 3-B-W29-3-P Poster PresentationYasutaka

Motomura

Laboratory for Innate Immune Systems, RIKEN

Center for Integrative Medical Sciences,

Yokohama, Japan

Regulation of ILC2-mediated antigen non-specific immune responses by cysteinyl

leukotriene

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100466 1-I-W17-9-P Poster Presentation Kohsuke IMAIDepartment of pediatrics, Tokyo Medical and

Dental University, Tokyo, JapanDiagnostic method for primary immunodeficiency using spectral flow cytometry

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100467 2-C-W21-4-P Poster Presentation Eiji KobayashiDepartment of Immunology, University of

Toyama, Toyama, Japan

TCR repertoire analysis of antigen-specific T cells using immunospot array assay on a chip

(T-ISAAC) technology

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

HallCell therapy Hiroaki Ikeda Koji Tamada

100468 3-B-W29-9-O/PPresentation: 11min,

Discussion: 2minMariko Kamioka

Division of Mucosal Immunology, Department of

Microbiology and Immunology, The Institute of

Medical Science, The University of Tokyo, Tokyo,

Japan

Innate and adaptive immune cells regulate Paneth cell granule formation and &alpha;-

defensin secretion

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100469 3-D-W32-14-O/PPresentation: 7min,

Discussion: 3minHiroshi HIGUCHI

School of Medicine, Tokai University, Kanagawa,

Japan

Phosphatidylserine-mediated incorporation of tumor-derived exosomes and phenotypic

changes in human macrophages

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100470 3-A-W27-9-P Poster Presentation Naoko NegishiAtopy (Allergy) Research Center, Juntendo

University Graduate School of Medicine, Tokyo,

Japan

CD155-mediated signaling through TIGIT is involved in serial transfer of tolerant state into

na&iuml;ve T cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100471 3-H-W40-16-P Poster Presentation Makiko Uchida

Department of Biological Science and

Technology, Graduate School of Industrial

Science and Technology, Tokyo University of

Science, Tokyo, Japan

Functional analysis of transcription factor Ehf.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

21 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100472 3-H-W40-17-P Poster Presentation Kazuki Saida

Laboratory of Molecular Biology and

Immunology, Department of Biological Science

and Technology, Faculty of Industrial Science

and Technology, Tokyo University of Science, 6-

3-1 Niijuku, Katsushika-ku, Tokyo 125-8585,

Mucosal mast cell differentiation is regulated by cross-talk between Notch signaling and

TGF-&beta; signaling.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100473 1-A-W1-12-P Poster Presentation Asako TanoueDepartment of Pulmonary Medicine, Graduate

School of Medical and Dental Sciences,

Kagoshima University, Kagoshima, Japan

The role of group III secreted phospholipase A2 in allergic asthmaDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100474 1-B-W4-7-O/PPresentation: 7min,

Discussion: 2minYukari Saito

Department of Immune Regulation, Research

Center for Hepatitis and Immunology, Research

Institute, National Center for Global Health and

Medicine, Chiba, Japan

Activation of NK/group1-innate lymphoid cells in adipose tissues depends on the

composition of fatty acids in high fat diet.

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100475 3-C-W31-15-O/PPresentation: 8min,

Discussion: 3minTakumi Kawasaki

Nara Institute of Science and Technology

(NAIST), Nara, Japan<strong>Obesity regulation by PIKfyve, a lipid kinase, in macrophage</strong>

Dec. 14

(Thu.), 201714:25-15:45 Room C

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100476 3-B-W29-8-O/PPresentation: 11min,

Discussion: 2minTakato Kobayashi

Laboratory for Innate Immune Systems, RIKEN

IMSCharacterization of group 2 innate lymphoid cells in glandular tissue

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100477 1-H-W16-8-O/PPresentation: 6min,

Discussion: 2minJae-won Chang

Graduate School of Frontier Sciences, The

University of Tokyo, Chiba, Japan

The first distinction and observation of single molecular dynamics between Interleukin-2 with

Intereleukin-2 receptor and Interleukin-15 with Interleukin-15 receptor through Diffracted X-

ray Tracking

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100478 3-I-W42-14-O/PPresentation: 7min,

Discussion: 3min

Akiko Hashimoto-

TaneRIKEN Center for Integrative Medical Science,

Yokohama, JapanMolecular assembly and function of PTPN22 in T cell receptor signaling

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100479 1-D-W7-1-O/PPresentation: 6min,

Discussion: 2minSatoshi Fukuyama

Division of Virology, Department of Microbiology

and Immunology, Institute of Medical Science,

University of Tokyo, Tokyo, Japan

Effect of aging on the host response to avian influenza A(H7N9) virus infection in non-

human primates

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100480 3-G-W39-10-O/PPresentation: 7min,

Discussion: 4min

Yoshimichi

Okayama

Allergy and Immunology Research Project Team,

Center for Institutional Research and Medical

Education, Nihon University School of Medicine

Autoantibodies (AAbs) against the Fc&epsilon;RI &alpha;-chain and IgE in patients with

chronic spontaneous urticaria (CSU) induced statistically higher ability of Fc&epsilon;RI

aggregation compared with non-atopic control (NC) subjects

Dec. 14

(Thu.), 201714:25-15:45 Room G

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100481 2-H-W24-1-O/PPresentation: 7min,

Discussion: 3minMiwa Sasai

Department of Immunoparasitology, Research

Institute for Microbial Diseases, Osaka

University, Osaka, Japan

<strong>Critical roles of GABARAPs on interferon-mediated cell-autonomous immune

responses against <em>T. gondii</em> infection</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100482 3-H-W41-4-O/PPresentation: 7min,

Discussion: 3minTaro Watabe

Department of gastroenterology, Tokyo Medical

and Dental University, Tokyo, Japan

Analysis of ileocecal immune response in an experimental colitis model using intra-vital

imaging

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100483 1-H-W15-2-O/PPresentation: 6min,

Discussion: 2minMayu Kaetsu

Department of Life Science and Medical

Bioscience, Waseda University, Tokyo, JapanColonic inflammation induces a transient increase in serum LECT2 level.

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100484 1-A-W2-8-O/PPresentation: 7min,

Discussion: 3minKazuya Takeda

Laboratory of Immune regulation, Immunology

Frontier Research center, Osaka University,

Suita, Japan

Ectopic T-B interaction for antigen-specific IgE antibody responses in nasal polyps of

Eosinophilic chronic rhinosinusitis patients

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100485 3-F-W36-16-P Poster Presentation Takayuki MIURADeptartment of Plastic and Reconstructive

Surgery, Tohoku University, Sendai, JapanEffect of Dectin-2-mediated signaling on skin wound healing and NETosis

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100486 3-F-W37-4-O/PPresentation: 7min,

Discussion: 2minChieko Ishifune

Department of Immunology and Parasitology,

Institute of Biomedical Sciences, Tokushima

University Graduate School, Tokushima, Japan

Notch signal controls the number of

TCR&alpha;&beta;<sup>+</sup>CD8&alpha;&alpha;<sup>+</sup> intraepithelial

lymphocytes via phospholipid asymmetry by maintaining fllipase ATP8a2

Dec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100487 3-B-W28-7-P Poster Presentation Masashi SATOHDepartment of Immunology, Kitasato University,

School of Medicine, Sagamihara, JapanGeneration of CD1d-negative NKT-cell hybridomas

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100488 3-H-W40-24-O/PPresentation: 7min,

Discussion: 3minTakuya OHTA

Department of Immune Regulation, Tokyo

Medical and Dental University Graduate School,

Tokyo, Japan

Skin-resident memory CD4<sup>+</sup> T cells play an essential role in acquired tick

resistance through IL-3-mediated basophil recruitment

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100489 3-E-W34-4-O/PPresentation: 7min,

Discussion: 3minSaori Fukao

Research Institute for Biomedical Sciences,

Tokyo University of Science, Chiba, JapanRegulation of IgE production by an RNA binding protein

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100490 1-E-W9-6-O/PPresentation: 7min,

Discussion: 3minSeitaro Nakagawa Department of Dermatology, Chiba University

<em>Staphylococcus aureus </em>virulent PSM&alpha; peptides induce keratinocyte IL-1

and IL-36 release to orchestrate IL-17-dependent skin inflammation

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100491 1-E-W9-5-O/PPresentation: 7min,

Discussion: 3minShogo Takatsuka

Dept. Chemother. Mycoses, Nat. Inst. Infect.

Dis.

Follicular helper NKT cells augment germinal center B cell formation by a protein-based

pneumococcal vaccine

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100492 3-H-W41-15-O/PPresentation: 7min,

Discussion: 3minAkira Taruya

Department of Cardiovascular Medicine,

Wakayama Medical University, Wakayama,

Japan

Decline of lysyl oxidase protein causes acute aortic dissection in Spi-B knockout miceDec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100493 1-B-W4-5-O/PPresentation: 7min,

Discussion: 2minMaehara Akie

Atopy (Allergy) Research Center, Juntendo

University Graduate School of Medicine, Tokyo,

Japan

Identification and characterization of a novel mutation of NLRP1 in a patient with a rare

disease involving severe liver fibrosis

Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

22 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100494 3-A-W26-8-P Poster Presentation Yuka TanakaDepartment of Gastroenterological and

Transplant Surgery, Hiroshima University,

Hiroshima, Japan

Human endothelial-like cells transdifferentiated from peripheral

CD14<sup>+</sup>monocytes inhibit T cells in response to allo-stimulation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100495 3-B-W28-8-P Poster PresentationShusaku

Kobayashi

Department of Immunology, Kitasato University

Graduate School of Medical Sciences,

Sagamihara, Japan

Cardiac CD1d+ cells that present &alpha;-GalCer and activate NKT cellsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100496 1-G-W13-6-O/PPresentation: 6min,

Discussion: 2minYukiko Doi

Department of Hematology and Oncology, Osaka

University Graduate School of Medicine, Suita,

Osaka, Japan

SATB1 expression is useful to identify the lymphoid-lineage-biased trajectory of functionally

fluctuating hematopoietic stem cells.

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100497 1-G-W13-2-P Poster Presentation Eriko SumiyaInstitute for Genetic Medicine, Hokkaido

University, Sapporo, JapanFate mapping of RANKL-expressing cells in the fetal bone

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100498 1-G-W13-19-P Poster Presentation Satomi Komori

Division of Molecular and Cellular Signaling,

Department of Biochemistry and Molecular

Biology, Kobe University Graduate School of

Medicine, Kobe, Japan

<strong>Development of a novel primary culture system for lymphoid organ fibroblastic

reticular cells</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100499 2-A-W19-5-O/PPresentation: 7min,

Discussion: 3minKiyoshi Hirahara

Department of Immunology, Graduate School of

Medicine, Chiba University

Memory-type ST2<sup>+</sup>CD4<sup>+</sup> T cells participate in the steroid-

resistant pathology of eosinophilic pneumonia

Dec. 13

(Wed.), 201714:25-15:45 Room A Mucosal-Skin Immunity-1

Kenji

KabashimaYoshiyuki Goto

100500 3-C-W30-11-O/PPresentation: 7min,

Discussion: 3minMiyuki Watanabe

Department of Molecular Immunology, Research

Institute for Microbial Diseases, Osaka

University, Osaka, Japan

Early FcR&gamma;-Erk signaling determines cytokine profile of dendritic cells through C-

type lectin receptors

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100501 2-G-W23-9-P Poster Presentation Takeshi WadaDivision of Molecular Medicine, Institute for

Genome Research, Tokushima University,

Tokushima, Japan

Exacerbation of oxazolone-induced atopic dermatitis in a mouse model of hyper-IgE

syndrome

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100502 3-G-W39-6-P Poster Presentation Hidekata YasuokaDivision of Rheumatology, Department of

Internal Medicine, Keio University School of

Medicine, Tokyo, Japan

Phenotype of platelet is altered in circulation of patients with rheumatoid arthritisDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100503 2-C-W21-9-O/PPresentation: 10min,

Discussion: 3minSeiji Nagano

Institute for Frontier Life and Medical Sciences,

Kyoto University

<strong>iPSCs transduced with TCR gene give rise to potent CTLs with antigen specific

cytotoxic activity comparable to those from T-iPSCs </strong>

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100504 3-F-W37-3-P Poster Presentation Ryoki KobayashiNihon University, School of Dentistry at Matsudo,

Chiba, Japan

Characterization of Innate lymphoid cells in inflamed gingiva of mice infected with

<em>Porphyromonas gingivalis</em>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100505 3-I-W43-7-P Poster Presentation Shizue Tani-ichiInstitute for Frontier Life and Medical Sciences,

Kyoto University, Kyoto, Japan

Exploring the signals upregulating IL-7R&alpha; expression via NF&kappa;B activation in T

cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100506 1-C-W5-6-O/PPresentation: 7min,

Discussion: 3minDaisuke Kamimura

Psychoimmunology, Institute for Genetic

Medicine, Graduate School of Medicine,

Hokkaido University, Sapporo, Japan

<strong>Light-Gateway Reflex; Photopic light suppresses retinal inflammation via down-

regulation of a regional adrenergic pathway</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100507 3-D-W32-7-O/PPresentation: 7min,

Discussion: 3minTaiki Moriya

Laboratory of Immunology, Faculty of Pharmacy,

Osaka Ohtani University, Osaka, Japan

Tumor cell death induction enhances tumor infiltrating dendritic cell migration and increases

in tumor antigen-specific T cells.

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100508 1-H-W15-4-O/PPresentation: 6min,

Discussion: 2minSunyi Joo

Division of Mucosal Immunology, Department of

Microbiology and Immunology, The Institute of

Medical Science, The University of Tokyo, Japan

<strong>Critical role of the CCR5-CCL5 cascade for the preferential migration of HSV-2-

specific effector cells to the vaginal mucosa upon intranasal immunization </strong>

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100509 3-C-W30-4-P Poster Presentation Hideki ArimochiGraduate School of Biomedical Sciences,

Tokushima University, Tokushima, Japan

FXR as a regulator of <em>Psmb8</em> expression is associated with macrophage

differentiation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100510 3-A-W27-11-P Poster PresentationTomoyuki

YamaguchiResearch Institute Nozaki Tokushukai, Osaka,

Japan

<strong>A simulation model of immune response predicts essential functions of Treg to

maintain immune tolerance</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100511 3-B-W28-9-P Poster PresentationIwayama

ToshitsuguKitasato University School of Medicine,

Sagamihara, Japan

Development of experimental autoimmune myocarditis model and experimental therapeutics

with NKT cell ligands

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100512 1-G-W13-21-P Poster Presentation Yoshihiro UedaMolecular Genetics, Institute of Biomedical

Science, Kansai Medical University

<strong>Regulation of cell polarization by Rap1 via NDR/Rab8 axis upon chemokine

stimulation</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100513 1-I-W18-12-P Poster Presentation Kazuki SakamotoPharmaceutical Sciences, Tokyo University of

Science, Chiba, JapanDysregulation of humoral immunity in Foxp3 conditional knockout mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100514 3-D-W33-12-P Poster Presentation Makoto TsuijiDepartment of Microbiology, Hoshi University

School of Pharmacy and Pharmaceutical

Sciences

Effects of linoleic acid oxide 13-HODE and 13-HPODE on immune responses.Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100515 3-H-W40-18-P Poster Presentation Kumi IzawaAtopy (Allergy) Research Center, Juntendo

University School of Medicine, Tokyo, Japan

<strong>Mast cell- and IgE-dependent anaphylaxis is regulated by paired receptors LMIR3

and LMIR7</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

23 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100516 3-A-W27-1-O/PPresentation: 10min,

Discussion: 3minRyoji Kawakami

Immunology Frontier Research Center, Osaka

university, Osaka, JapanEpigenomic signatures of extrathymic-derived regulatory T-cells

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100517 1-E-W9-15-O/PPresentation: 7min,

Discussion: 3minAyako Kaitani

Atopy (Allergy) Research Center, Juntendo

University School of Medicine, Tokyo, Japan

CD300f suppresses neutrophil recruitment to LPS-injected skin: A role of CD300f in gram-

negative bacterial skin infections

Dec. 12

(Tue.), 201713:20-14:40 Room E

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100518 3-I-W42-3-P Poster Presentation Matsui YukihideDepartment of molecular immunology, the faculty

of medicine, Toho University, Tokyo, Japan

TCR-stimulation recruits CBP from nucleus to the cytoplasm and affects the protein

phosphorylation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100519 1-A-W2-16-O/PPresentation: 7min,

Discussion: 3minAyako Takamori

Atopy (Allergy) Research Center, Juntendo

University School of Medicine, Tokyo, Japan

<strong>Ceramide-CD300f interaction inhibits Mrgprb2-mediated mast cell activation and

pseudo-allergic drug reactions in mice</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room A

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100520 3-H-W40-19-P Poster Presentation Shino UchidaAtopy (Allergy) Research Center, Juntendo

University School of Medicine, Tokyo, Japan

<strong>A critical role of an inhibitory receptor LMIR3 in the pathogenesis of food

allergy</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100521 3-I-W42-16-P Poster Presentation Koji Eshima Kitasato University School of MedicineImplication of T-bet, the master regulator of Th1 cells, in the cytotoxicity of murine

CD4<sup>+</sup> T cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100522 1-B-W3-11-P Poster Presentation Motoya MuraseGraduate School of Biological Sciences, Nara

Institute of Science and Technology (NAIST),

Nara, Japan

Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through

Toll-like receptor 4 trafficking

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100523 3-E-W34-13-P Poster Presentation Nazim MedzhidovDepartment of Immunology, Medical Research

Institute, Tokyo Medical and Dental University,

Tokyo, Japan

<strong>Role of poor B cell receptor ubiquitination in efficient antigen presentation</strong>Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100524 1-C-W5-11-P Poster PresentationNatsumi

NakayamaLaboratory of Biochemistry, Azabu University The role of gangliosides in CNS autoimmune diseases

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100525 1-I-W17-10-P Poster Presentation JeongHoon ParkDepartment of Immunopathology, IFReC, Osaka

University, Osaka, Japan

<strong>Study of Human Autoimmune Diseases Enabled by Gene Editing in Reporter Cell

Lines</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100526 1-I-W17-11-P Poster Presentation Yuka KobayashiLaboratory of Immunology, Institute for Frontier

Life and Medical Sciences, Kyoto University,

Kyoto, Japan

The construction and application of human-type artificial lymphoid tissuesDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100527 3-E-W35-6-O/PPresentation: 7min,

Discussion: 3minAri Itoh-Nakadai

Department of Experimental Immunology,

Institute of Development, Aging and Cancer,

Tohoku University, Tokyo, Japan

Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cellsDec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100528 1-C-W5-8-O/PPresentation: 7min,

Discussion: 3minYasunobu Arima

Division of Psychoimmunology, Institute for

Genetic Medicine and Graduate School of

Medicine, Hokkaido University, Sapporo, Japan

Stress-Gateway Reflex, which establishes brain micro-inflammation at specific vessels,

creates a new neural pathway, which induces the dysregulation of organ homeostasis

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100529 1-B-W4-2-O/PPresentation: 7min,

Discussion: 2minEri Kumaki

Department of Pediatrics and Developmental

biology, Tokyo Medical and Dental University

Graduate School of Medical and Dental

Sciences, Tokyo, Japan

Abberant Neutrophil Function in <em>PSTPIP1</em> mutationsDec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100530 3-C-W30-8-P Poster Presentation Satoshi FujiyamaDepartment of Immunology, Faculty of Medicine,

University of Tsukuba , Ibaraki, JapanIdentification of marginal zone macrophages by means of flow cytometry

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100531 3-C-W31-2-P Poster Presentation Tatsuo KatagiriDepartment of (Pharm)Biology Graduate School

of Medicine and Pharmaceutical Sciences,

University of Toyama, Toyama, Japan

Analysis of macrophage anti-tumor activating component derived from<em> Polyporus

alveolaris</em> extract (PAE)

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100532 1-I-W17-19-P Poster Presentation Atsushi KadowakiNational Institute of Neuroscience, National

Center of Neurology and Psychiatry, Tokyo,

Japan

CCR9+ CD4+ memory T cells dependent on gut microbiota and age are altered in

secondary progressive multiple sclerosis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100533 1-B-W3-13-P Poster Presentation Hideki SanjoDepartment of Molecular and Cellular

Immunology, Shinshu University Schhol of

Medicine, Nagano, Japan

Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a

TNF-independent mechanism

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100534 1-H-W16-1-O/PPresentation: 6min,

Discussion: 2minKazuo Okamoto

Department of Osteoimmunology, Graduate

School of Medicine and Faculty of Medicine, The

University of Tokyo, Tokyo, Japan

A distinct role of an EF-hand motif protein in the hematopoietic cell lineageDec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100535 1-C-W5-2-O/PPresentation: 7min,

Discussion: 3minChenyang ZHANG

Department of Immunology, National Institute of

Neuroscience, National Center of Neurology and

Psychiatry, Kodaira, Tokyo, Japan.

<strong>Antigen-presenting cells promote Eomes expression in helper T cells through

ectopic expression of prolactin under chronic neuroinflammation</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100536 3-A-W26-9-O/PPresentation: 10min,

Discussion: 3minXiaotong Cui

Laboratory of Infection and Prevention,

Department of Virus Research, Institute for

Frontier Life and Medical Sciences, Kyoto

University, Kyoto, Japan

<strong>Interactions between Regnase-1 and Roquin Regulate Helper T Cell

Polarization</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100538 2-F-W22-8-O/PPresentation: 8min,

Discussion: 3minTakeshi Nitta

Department of Immunology, The University of

Tokyo, Tokyo, Japan<strong>Human thymoproteasome variations influence CD8 T cell repertoire</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room F

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

24 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100539 3-F-W37-5-P Poster Presentation Taku NaitoDepartment of Molecular Immunology, Toho

University School of Medicine, Tokyo, JapanMaintenance of intestinal homeostasis by T cell-expressed Eed.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100540 1-G-W13-14-P Poster Presentation Toshiki TezukaDivision of Development and Aging, Research

Institute for Biomedical Sciences, Tokyo

University of Science, Chiba, Japan

Defects in splenic architectural organization by postnatal deletion of the gene encoding a

transcription factor Tlx1 in spleen mesenchymal cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100541 3-F-W36-6-P Poster Presentation Toshiyuki KojimaDepartment of Immune Regulation, Tokyo

Medical and Dental University, Tokyo, Japan.

Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific

ligands of inhibitory receptor CD200R

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100542 2-F-W22-11-P Poster Presentation Masashi KajitaInstitute of Industrial Science, The University of

Tokyo, JapanAffinity amplification for selective T cell response to specific ligands

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100543 1-I-W18-9-O/PPresentation: 7min,

Discussion: 3minHarada Yasuyo

Research Institute for Biomedical Science, Tokyo

University of Science, Chiba, Japan

<strong>Role of follicular helper T cells and TH2 cells in IgE mediated

</strong><strong>active cutaneous anaphylaxis</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100544 2-B-W20-12-O/PPresentation: 7min,

Discussion: 3minTakuto Ohki

Division of Psychoimmunology, Institute for

Genetic Medicine, Graduate School of Medicine,

Hokkaido University

<strong>Symmetric-Gateway Reflex, which develops </strong><strong>symmetrical

inflammation between joints is induced by the specific sensory pathway in a rheumatoid

arthritis model</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room B

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100545 1-C-W6-9-O/PPresentation: 7min,

Discussion: 3minNamiko Okabe

Department of Rheumatology and Clinical

Immunology, Graduate School of Medicine,

Kyoto University, Kyoto, Japan

Myelin basic protein promotes experimental arthritis via non-T cells.Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100546 3-H-W40-25-P Poster Presentation Yuya TABAKAWADepartment of Immune Regulation, Tokyo

Medical and Dental University Graduate School,

Tokyo, Japan

Histamine plays a critical role in acquired protective immunity against tick infestationDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100547 1-I-W18-14-P Poster Presentation Yuriko TanakaDepartment of Molecular Immunology, Toho

University School of Medicine, Tokyo, JapanThe presence of T cells with both Th1 and Th2 characteristics in mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHelper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100548 1-I-W17-20-P Poster Presentation Morita Kentaro

Department of Immunology and Parasitology,

School of Medicine, University of Occupational

and Environmental Health, Japan, Kitakyushu,

Japan

Effect of triterpenoid anticancer drug CuD on peripheral blood lymphocytes from a patient

with recurrent ATLL

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100549 2-H-W24-7-O/PPresentation: 7min,

Discussion: 3minFumiji Saito

Research Institute for Microbial Diseases, Osaka

University, Osaka, Japan

<strong>Immune evasion of <em>Plasmodium falciparum</em> by RIFIN

</strong><strong>via inhibitory receptor</strong>

Dec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100550 2-I-W25-13-O/PPresentation: 7min,

Discussion: 3minYuta Shimizu

Department of Immunochemistry, Research

Institute for Microbial Disease, Osaka University,

Laboratory of Immunochemistry

Chemical compounds that specifically inhibit aberrant MHC class II expressionDec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100551 1-G-W13-9-O/PPresentation: 6min,

Discussion: 2minTatsuya Shishido

Department of Immunochemistry, Research

Institute for Microbital Disease, Osaka UniversityCrucial role of CD74 in hematopoietic cell differentiation

Dec. 12

(Tue.), 201713:20-14:40 Room G

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100552 3-G-W38-7-O/PPresentation: 7min,

Discussion: 4minYuki Sasagawa

Laboratory of Immunochemistry, WPI

Immunology Frontier Reseach Center, Osaka

University, Osaka, Japan

Antiphospholipid antibody recognizes &beta;2GPI complexed with HLA class II molecules

via its domain V

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100553 1-A-W2-17-P Poster Presentation Narumi SuzukiLaboratory for Cytokine Regulation,Research

Center for Integrative Medical Science ,RIKEN

Yokohama Institute,Yokohama,japan

E4BP4/NFIL-3 is a critical transcription factor to control TH2 attraction into inflammation site

during chronic allergic responses.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100554 2-G-W23-10-P Poster Presentation Tsukasa UgajinTokyo Medical and Dental University, Tokyo,

Japan

<strong>Bilirubin oxidation derived from oxidative stress is associated with disease severity

of atopic dermatitis</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100555 2-I-W25-12-O/PPresentation: 7min,

Discussion: 3minMatsumoto Minoru

Division of Molecular Immunology, Institute for

Enzyme Research, Tokushima University,

Tokushima, Japan

Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the

impaired presentation of self-antigens in the pancreas

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100556 3-I-W43-2-P Poster Presentation Yuki TABATAResearch Institute for Biomedical Sciences,

Tokyo University of Science, Chiba, Japan

<strong>IL-2 production is negatively regulated by free fatty acid receptor 2 (Ffar2)

mediated signaling.</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100557 3-I-W43-3-P Poster Presentation Masanobu KimuraDepartment of Microbiology and Immunology,

Tohoku University Graduate School of Medicine,

Sendai, Japan

<strong>TRAF2 and TRAF5 binding to the signal transducing receptor gp130 inhibit JAK1

activation in the IL-6-receptor signaling complex</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100558 3-F-W37-13-P Poster Presentation Sachi TanakaGraduate School of Agriculture, Shinshu

University, Nagano, JapanCaloric restriction ameliorates dextran sulfate sodium-induced colitis in mice

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100559 3-F-W36-7-P Poster Presentation Masako KohyamaDepartment of Immunochemistry, Research

Institute for Microbial Diseases, Osaka UniversityIntestinal epithelial homeostasis regulated by CD74

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100560 3-F-W37-16-P Poster Presentation Naoki TakemuraDepartment of Mucosal Immunology, School of

Medicine, Chiba University, Chiba, Japan

Prime-boost vaccination with CpG ODN and curdlan strongly induces both systemic and

mucosal immunity

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

25 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100561 3-I-W42-1-P Poster Presentation Manabu InobeInstitute of Medical, Pharmaceutical and Health

Sciences, Kanazawa University, Kanazawa,

Japan

CD8<sup>+</sup> T cells are less dependent on Erk to proliferate compared with

CD4<sup>+</sup> T cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100562 3-A-W26-10-O/PPresentation: 10min,

Discussion: 3minKazuki Kishida

Department of Immunochemistry, Research

Institute for Microbial Diseases, Osaka University<strong>Antigen-specific immune regulation mediated by TCR-like antibodies</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room A

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100563 3-I-W43-11-O/PPresentation: 7min,

Discussion: 3minAkio Ohta

Department of Molecular Medicine, Foundation

for Biomedical Research and Innovation, Kobe,

Japan

Transient hypoxia persistently inhibits T cell activationDec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100564 3-A-W27-15-O/PPresentation: 10min,

Discussion: 3minReiko Takahashi

Research Institute Nozaki Tokushukai, Daitou,

Japan

Inhibition of melanoma proliferation by immunologic mechanism including the plasticity of

SOCS1 deficient regulatory T cells

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100565 1-F-W11-4-O/PPresentation: 9min,

Discussion: 2minShime Hiroaki

Department of Immunology,?Nagoya City

University Graduate School of Medical Sciences,

Nagoya, Japan

Toll-like receptor 2 ligand and interferon-&gamma; suppress anti-tumor T cell responses by

enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100566 3-B-W29-1-O/PPresentation: 11min,

Discussion: 2minTakashi Ebihara

Laboratory for Transcriptional Regulation, RIKEN

Center for Integrative Medical Sciences

Runx proteins suppress constitutive activity of ILC2 and prevent ILC2 exhaustion after

activation

Dec. 14

(Thu.), 201714:25-15:45 Room B

Innate Lymphocyte-2

(ILC1,2,3)

Susumu

NAKAE

Shinichiro

SAWA

100567 1-G-W13-22-P Poster Presentation Toshihiro KomatsuDepartment of Immunology, School of Medicine,

Kochi University, Kochi, Japan

Extravasation of CTLs occurs by recognizing the MHC-peptide complexes cross-presented

by vascular endothelial cells.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100568 1-G-W13-23-P Poster Presentation Junya OhtakeCancer Vaccine Center, Kanagawa Cancer

Center, Yokohama, Japan

<strong>Comprehensive analysis of immunological tumor environment in colorectal

cancer</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Hematopoiesis and immune

environments

Takashi

Nagasawa

Hitoshi

Takizawa

100569 1-I-W17-12-P Poster Presentation Hirofumi ShibataDepartment of Pediatrics, Kyoto University

Graduate School of Medicine, Kyoto, Japan

A novel human Cytotoxic Lymphocyte-based functional assays for primary hemophagocytic

lymphohistiocytosis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100570 3-A-W27-12-P Poster Presentation YUN GUODepartment of Immunology, Graduate School of

Biomedical &amp; Health Sciences, Hiroshima

University, Hiroshima, Japan

Ubiquitin-modifying enzyme A20 plays a role in regulatory T cellsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100571 2-C-W21-8-O/PPresentation: 10min,

Discussion: 3minRaul Vizcardo

Surgery Branch, National Cancer Institute,

National Institutes of Health, Bethesda MD, USADeveloping the next generation of iPSC cell-based immunotherapies

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100572 3-C-W31-18-P Poster Presentation Noriko MutohDepartment of Oral Interdisciplinary Medicine,

Division of Pulp Biology, Kanagawa Dental

university, Yokosuka, Japan

Innate immune response induce the dentin regeneration in dental pulpDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Dendritic cells and

Macrophages-3: Inflammatory

Responses

Tsuneyasu

Kaisho

Rikinari

Hanayama

100573 3-G-W38-8-O/PPresentation: 7min,

Discussion: 4minSatoko Morikami

Department of Obstetrics and Gynecology, Kobe

University Graduate School of Medicine, Hyogo,

Japan

Prothrombin complexed with HLA class II molecules is an autoantibody target in

antiphospholipid syndrome

Dec. 14

(Thu.), 201712:50-14:10 Room G

Systemic autoimmune

disease (2)Yoshiya Tanaka

Masayuki

Nishide

100574 3-D-W33-1-O/PPresentation: 7min,

Discussion: 3minOkumura Genki

Department of Immunology, Faculty of medicine,

University of TsukubaThe role of soluble CD155 in tumor immune response and metastasis

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100575 3-D-W33-9-O/PPresentation: 7min,

Discussion: 3minSatoshi Ueha

Department of Molecular Preventive Medicine,

Graduate School of Medicine, The University of

Tokyo, Tokyo, Japan

TCR sequencing reveals the generation and expansion of tumor-specific CD8<sup>+

</sup>T cell clones after anti-CD4 antibody treatment in tumor-bearing mice

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100576 1-C-W6-11-O/PPresentation: 7min,

Discussion: 3minSoo-hyun Chung

Center for Animal Disease Models, Research

Institute for Biomedical Sciences, Tokyo

University of Science, Noda, Japan

Truncated glycan and C-type lectin ; a new therapeutic target for autoimmune arthritiDec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100577 1-E-W10-2-P Poster PresentationMasayuki

UmemuraTropical Biosphere Research Center, University

of the Ryukyus, Okinawa, Japan

Involvement of IL-17A-producing TCR &gamma;&delta;<sup>+</sup> T cells in late

protective immunity against pulmonary <em>Mycobacterium tuberculosis </em>infection

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100578 3-A-W27-10-O/PPresentation: 10min,

Discussion: 3min

Chikako

ShimokawaDepartment of Parasitology, Graduate School of

Medicine, Gunma University, GunmaSuppression of type 1 diabetes in mice infected with an intestinal nematode

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100579 1-E-W10-11-P Poster Presentation Yuki SATOMedical Microbiology, Mycology and

Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

Effect of Mincle-deficiency on the host immune response against <em>Cryptococcus

neoformans</em> infection

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100580 2-H-W24-11-O/PPresentation: 7min,

Discussion: 3minPiyarat Srinontong

Department of Parasitology and Infectious

Diseases, Gifu University Graduate School of

Medicine, Gifu, Japan

Regulation of Visceral Leishmaniasis by Secreted Immunoglobulin DeficiencyDec. 13

(Wed.), 201714:25-15:45 Room H

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100581 3-E-W34-14-P Poster Presentation Yangyang FengDepartment of Immunology, Medical Research

Institute, Tokyo Medical and Dental University

<strong>Role of NADPH oxidases in BCR ligation-induced ROS production and

activation</strong>

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100582 3-I-W43-14-O/PPresentation: 7min,

Discussion: 3minHisako Akatsuka

Department of Host Defense Mechanism, Tokai

University School. of Medicine, Kanagawa Japan

AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through ATG7-

independent pathway

Dec. 14

(Thu.), 201714:25-15:45 Room I T cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

26 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100583 2-G-W23-11-P Poster Presentation Masayuki KitajimaDepertment of Immunology and Pathology,

Research Institute National Center for Global

Health and Medicine

Role of TSLPR on CD4 T cells in exacerbation of skin inflammation.Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100584 3-F-W37-9-P Poster Presentation Hisashi UetaDepartment of Anatomy (Macro), Dokkyo

Medical University, Tochigi, Japan

Peyer&rsquo;s patch functions as a transition site for rapid recirculation of lymphocytes

during gut immunosurveillance: multicolor immunohistochemical study

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100585 3-E-W35-4-O/PPresentation: 7min,

Discussion: 3minWataru Ise

Immunology Frontier Research Center, Osaka

University, Osaka, JapanThe heightened T-B interaction associates with plasma-prone germinal center B cells

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100587 1-D-W7-7-O/PPresentation: 6min,

Discussion: 2min

Takeharu

Minamitani

Laboratory of Infectious Diseases and Immunity,

National Institutes of Biomedical Innovation,

Health, and Nutrition, Ibaraki, Osaka, Japan

T cell and NK cell-mediated immune surveillance interferes with Epstein-Barr virus LMP-

induced lymphomagenesis in germinal center B cells

Dec. 12

(Tue.), 201713:20-14:40 Room D Virus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100588 1-C-W5-1-O/PPresentation: 7min,

Discussion: 3minBen Raveney

Department of Immunology, National Institute of

Neuroscience, NCNP, Kodaira, Tokyo, Japan

Eomes-positive cytotoxic T helper cells: a new pathogenic immune cell subset in secondary

progressive multiple sclerosis?

Dec. 12

(Tue.), 201713:20-14:40 Room C

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100589 3-A-W27-4-O/PPresentation: 10min,

Discussion: 3min

Yumi Yamashita-

KanemaruDepartment of Immunology, Faculty of Medicine,

University of Tsukuba, Tsukuba, Ibaraki, JapanDNAM-1 limits Treg cell function via TIGIT-dependent manner

Dec. 14

(Thu.), 201714:25-15:45 Room A

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100590 1-A-W1-15-P Poster Presentation Masashi IkutaniDepartment of Immune Regulation, Research

Institute, National Center for Global Health and

Medicine, Chiba, Japan

Chronic IL-33-induced inflammation results in pulmonary arterial hypertrophyDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-1 : Lower airway

allergic inflammationKenji Izuhara Koubun Yasuda

100591 1-H-W16-16-P Poster Presentation Kei MatsunoDepartment of Respiratory Medicine, Juntendo

University School of Medicine, Tokyo, Japan

TWEAK enhances epithelial mesenchymal transition and chemokine production in human

bronchial epithelial cells

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100592 2-F-W22-4-P Poster Presentation Honomi SaitoDepartment of Molecular and Cellular

Immunology, Shinshu University School of

Medicine, Matsumoto, Japan

Forced over-expression of T-bet transcription factor in thymocytes inhibits DN to DP

transition

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100593 2-B-W20-16-P Poster Presentation Chiharu TomiDepartment Immunology, National Institute of

Neuroscience, NCNP, Kodaira, Tokyo, Japan

Roles of NR4A2 for pathogenic properties of autoreactive T helper cells in lupus-prone

mice.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100594 3-I-W42-10-O/PPresentation: 7min,

Discussion: 3minYuji Kamioka

Department of Molecular Genetics, Institute of

Biomedical Science, Kansai Medical University,

Osaka, Japan

Roles of Rap1 and Kindlin-3 in lymphocyte homing to peripheral lymph nodesDec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100595 3-A-W26-3-P Poster Presentation Ami TakahashiLaboratory of Biomolecular Science, Faculty of

Pharmaceutical Sciences, Hokkaido University,

Hokkaido, Japan

HLA-G2 gives immunosuppressive effects to human monocytes and dendritic cellsDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -1Taku Okazaki

Shunsuke

Chikuma

100596 2-F-W22-16-P Poster Presentation Takeyuki ShimizuDepartment of Immunology, School of Medicine,

Kochi University, Kochi, Japan

Construction of a TAP deficient HLA class I-binding assay system with the use of

CRISPR/Cas9 system

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100597 3-B-W28-3-P Poster Presentation Maia InoueDepartment of Immunology, Graduate School of

Medicine and Faculty of Medicine, The University

of Tokyo, Tokyo, Japan

A critical epigenetic regulator of early iNKT cell developmentDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100598 3-E-W35-5-O/PPresentation: 7min,

Discussion: 3minAtsuko Kayaba

Department of Experimental Immunology,

Institute of Development, Aging and Cancer,

Tohoku University, Sendai, Japan

PIR-B suppresses IL-6 secretion from mesenchymal stem cells and regulates the

immunoglobulin production of plasma cells.

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100599 3-D-W32-15-P Poster Presentation Masaki TamiyaDivision of Cell signaling, Institute for Advanced

Medical Research, Keio University school of

Medicine

Reversal of anti-PD-1/PD-L1 therapy resistance by modulation of tumor-associated

macrophages using CSF-1 receptor blockade

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100600 1-D-W8-7-O/PPresentation: 6min,

Discussion: 2.5minDaichi Yamasoba

Laboratory of Infection and Prevention, Institute

for Frontier Life and Medical Sciences, Kyoto

University, Kyoto, Japan

Identification of a novel HIV-1 restriction factor which selectively degrades viral transcripts.Dec. 12

(Tue.), 201714:55-16:15 Room D Virus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100601 3-F-W36-17-O/PPresentation: 7min,

Discussion: 3minSaeko Nakajima

Department of Dermatology, Kyoto University

Graduate School of Medicine

<em>Candida albicans</em> skin colonization exacerbates the inflammation of murine

psoriasis-like dermatitis

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100602 1-C-W5-12-P Poster Presentation AKIBA YasushiDepartment of Molecular Immunology, Toho

University School of Medicine, Tokyo, Japan

Nuclear protein SATB1 is required for development of experimental autoimmune

encephalomyelitis

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases I

Mitsuru

Matsumoto

Daisuke

Kamimura

100603 1-E-W10-1-O/PPresentation: 7min,

Discussion: 3minEi'ichi Iizasa

Department of Immunology, Field of Infection

and Immunity, Graduate School of Medical and

Dental Sciences, Kagoshima University,

Kagoshima

Two ITAM-coupled receptors recognizing Mycobacterial mycolic acid-containing lipids and

having the different roles.

Dec. 12

(Tue.), 201714:55-16:15 Room E

Immune response to

mycobacteial and fungal

infections

Kazuyoshi

KawakamiHiromitsu Hara

100604 3-H-W40-20-O/PPresentation: 7min,

Discussion: 3minShota Toyoshima

Allergy and Immunology Research Project Team,

Center for Institutional Research and Medical

Education, Nihon University School of Medicine,

Tokyo, Japan

Comparison of microRNA in human mast cell-derived exosomes in innate and acquired

immunity

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100605 2-G-W23-12-P Poster Presentation Michiyuki KasaiDepartment of Immunology, School of Medicine,

Kochi University,

Application with nano-sized cyanoacryl particles ameliorates experimental dermatitis through

the bacteriocidal activity

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

27 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100606 2-I-W25-15-P Poster Presentation Kouta FujikuraChiba Institute of Technology, Graduate School

of Engineering, Department of Life and

Environmental Sciences, Narashino,Japan

Bioimaging Analysis for Endocytosis of macrophage in inframmation regulated by v-ATPaseDec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100607 2-I-W25-4-O/PPresentation: 7min,

Discussion: 3minKeita Aoi

Department of Immunology and Cell Biology,

Graduate School of Medicine / Frontier

Biosciences, Osaka University, Osaka, Japan

Oral mucosa-specific macrophage subsets contribute to tolerance induction in sublingual

immunotherapy

Dec. 13

(Wed.), 201714:25-15:45 Room I

Dendritic cells and

Macrophages-1: Organ-

specific Immune Tolerance

Satoshi Ishido Kenichi Asano

100608 3-F-W36-8-P Poster Presentation Terufumi KuboDepartment of Pathology, Sapporo Medical

University School of Medicine, Sapporo, Japan

Differential bronchial epithelial response regulated by deltaNp63: a potential mechanism

explaining chronicity of asthma

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100609 3-I-W42-4-O/PPresentation: 7min,

Discussion: 3minRyunosuke Muro

Graduate School of Medicine and Faculty of

Medicine, The University of Tokyo, Japan

Control of proinflammatory &gamma;&delta;T cell development by linage-specific TCR

signaling pathway

Dec. 14

(Thu.), 201712:50-14:10 Room I T cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100610 3-E-W35-3-O/PPresentation: 7min,

Discussion: 3minKei Haniuda

Research Institute for Biomedical Sciences,

Tokyo University of Science, Chiba, JapanGerminal center B cell development by glycolysis and mitochondrial metabolism

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100611 1-H-W15-16-P Poster Presentation Numasaki Muneo Tohoku University Hospital, Sendai, Japan IL-32 promotes the cell growth of malignant methotheliomaDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallCytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100612 3-D-W33-13-P Poster PresentationYoshinori

TAKAHASHIDepartment of Pulmonary and Critical Care

Medicine, Mie University Hospital, Japan

Biomarkers including circulating PD-L1 and PD-1 in human (L858R) EGFR mutant

transgenic mice with lung cancer

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100613 3-E-W34-6-O/PPresentation: 7min,

Discussion: 3minAdachi Takahiro

Department of Immunology, Medical Research

Institute, Tokyo Medical and Dental University,

Tokyo, Japan

Intravital imaging of Ca<sup>2+</sup> signals in lymphocytes of the Ca<sup>2+</sup>

biosensor YC3.60 transgenic mice

Dec. 14

(Thu.), 201712:50-14:10 Room E

B cell development and

function

Yoshiteru

SasakiReiko Shinkura

100614 1-B-W3-1-O/PPresentation: 7min,

Discussion: 2minRyota Sato

Division of Innate Immunity, The Institute of

Medical Science, The University of Tokyo, Japan

<strong>Requirement of glycosylation machinery in Toll-like receptor responses revealed by

CRISPR/Cas9 screening </strong>

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100615 3-I-W43-10-P Poster Presentation Yoichi MaekawaDepartment of Parasitology and Infectious

Diseases, Gifu University Graduate School of

Medicine, Gifu, Japan

The immune responses of CD4<sup>+</sup> T cells are affected by hypergravityDec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-3 : T cell function Harumi Suzuki Ei Wakamatsu

100616 3-H-W40-21-O/PPresentation: 7min,

Discussion: 3min

Jun-ichi

Kashiwakura

Department of Immunology, Graduate School of

Pharmaceutical Sciences, Hokkaido University,

Hokkaido, Japan

STAP-2 is an adopter molecule to positively regulate basophil activationDec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100617 1-F-W11-9-O/PPresentation: 9min,

Discussion: 2minkagawa Masaki

Division of Cellular Signaling Institute, for

Advanced Medical Research, Keio University

School of Medicine

Immunomodulation of ovarian clear cell carcinoma by targeting HNF-1&beta;-NF-kB-IL6

pathway enhances anti-tumor immunity

Dec. 12

(Tue.), 201713:20-14:40 Room F

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

100618 1-C-W6-2-O/PPresentation: 7min,

Discussion: 3minIkuma Nakagawa

Division of Psychoimmunology, Institute for

Genetic Medicine, Hokkaido University,

Hokkaido, Japan

<strong>Primary Sj&ouml;gren&rsquo;s syndrome-associated gene<em> STF1</em>

regulates inflammation via </strong><strong>NF-</strong><strong>k</strong><strong>B

pathway</strong>

Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100619 1-B-W4-6-O/PPresentation: 7min,

Discussion: 2min

Kiyoharu

Fukushima

Department of Host Defense, Research Institute

for Microbial Diseases (RIMD), Osaka University,

Osaka, Japan.

Screening of causative genes for fibrosis development in mice.Dec. 12

(Tue.), 201714:55-16:15 Room B

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100620 1-I-W18-3-O/PPresentation: 7min,

Discussion: 3minKeiko Yasuda

Laboratory of Experimental Immunology, Institute

for Frontier Life and Medical Sciences, Kyoto

University, Kyoto, Japan

Satb1 controls the differentiation and terminal effector function of Th17 cellsDec. 12

(Tue.), 201714:55-16:15 Room I Helper T cells

Masakatsu

YAMASHITA

Motoko Y.

KIMURA

100621 3-F-W36-4-P Poster Presentation Ichiro TakahashiDepartment of Mucosal Immunology, Dental

School, Hiroshima University, Hiroshima, Japan

Metabolic demand of colonic macrophages for symbiotic and cytosolic colonization by non-

lymphoid tissue resident commensal bacteria

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100622 3-C-W30-3-O/PPresentation: 7min,

Discussion: 3minNobuyuki Onai

Department of Immunology, Kanazawa Medical

University, Ishikawa, JapanRegulation of pDC development by graded expression of E2-2

Dec. 14

(Thu.), 201712:50-14:10 Room C

Dendritic cells and

Macrophages-2: Development

and Recognition

Tomohiko

Tamura

Masafumi

Nakayama

100623 2-H-W24-9-P Poster Presentation Mizuho TabataDepartment of Parasitology and Infectious

Diseases, Gifu University Graduate School of

Medicine, Gifu, Japan

Infection of parasitic nematode ameliorates imiquimod (IMQ)-induced psoriasisDec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Immune response to parasite

infections

Yoichi

Maekawa

Masahiro

Yamamoto

100624 3-F-W36-18-O/PPresentation: 7min,

Discussion: 3minGyohei Egawa

Department of Dermatology, Kyoto University

Graduate School of Medicine, Kyoto, Japan

<strong>Revisiting the concept of CHS response; effector T cells infiltrates into the hapten-

entry sites and confer long-lasting local memory</strong>

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100625 1-H-W15-9-O/PPresentation: 6min,

Discussion: 2minHironao Suzuki

Division of Psychoimmunology, Institute for

Genetic Medicine, Hokkaido University,

Hokkaido, Japan

<strong>RNA Splicing Mediator 1 (RSM1) regulates inflammation via alternative splicing of

DNA methyltransferase Dnmt3b</strong>

Dec. 12

(Tue.), 201713:20-14:40 Room H Cytokines and chemokines-1

Masaaki

MurakamiAkihiro Kimura

100626 3-D-W32-6-O/PPresentation: 7min,

Discussion: 3minKeisuke Fujii

Department of Immuno-Gene Therapy, Mie

University Graduate School of Medicine, Mie,

Japan

Phenotypic and clonality analysis of tumor-reactive CD8<sup>+</sup> T cells among TILs

in human colorectal tumor tissue

Dec. 14

(Thu.), 201712:50-14:10 Room D

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100627 1-I-W17-21-P Poster Presentation Shimizu Mikito Osaka University, Osaka, Japan

Febuxostat Ameliorates Secondary Progressive Experimental Autoimmune

Encephalomyelitis by Restoring Mitochondrial Energy Production in a GOT2-dependent

Manner

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

28 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100628 1-D-W8-13-P Poster Presentation Kazuya TAKEDAFaculty of Medicine, Tohoku Medical and

Pharmaceutical University, Sendai, Miyagi,

Japan

Theiler&rsquo;s virus fails to stimulate plasmacytoid dendritic cellDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-2 Takashi Fujita

Hiroyuki

Oshiumi

100629 1-B-W3-10-P Poster Presentation Asuka InoueResearch and Development, Sanofi K.K., Tokyo,

Japan

Immune regulation by inhibitory oligonucleotide ISM ODN for HMGB1 in inflammatory

disease models

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100630 1-C-W6-5-O/PPresentation: 7min,

Discussion: 3minMichio Yasunami

Saga-Ken Medical Centre Koseikan, Saga,

Japan

Principal contribution of <em>HLA-DQ</em> alleles, <em>DQB1*06:04</em> and

<em>DQB1*03:01</em>, to disease resistance against primary biliary cholangitis in a

Japanese population

Dec. 12

(Tue.), 201714:55-16:15 Room C

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100631 1-I-W17-22-P Poster Presentation Hiroyuki Yoshitomi

Institute for Frontier Life and Medical

Sciences、Kyoto University,Kyoto, Japan

Transcriptional regulation of PD-1<sup>+</sup>CD4<sup>+</sup>T cells under

inflammatory conditions

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100632 1-B-W3-9-P Poster Presentation Yuki NakajimaDepartment of Immunology, Graduate School of

Medicine, The University of TokyoIdentificdation of immunogenic endogenous RNA and its inhibitor

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100633 3-A-W27-13-P Poster Presentation Yoshihiro Oya

Department of Rheumatology, Allergy &amp;

Clinical Immunology National Hospital

Organization Chiba-East National Hospital ,

Chiba, Japan

Allo-specific Foxp3<sup>+</sup>CD4<sup>+ </sup>induced Tregs (allo-iTreg) suppress

specific-alloantigen, but not irrelevant alloantigen in vivo

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tolerance and immune

suppression -2

Naganari

OhkuraTakashi Sekiya

100634 3-D-W33-6-O/PPresentation: 7min,

Discussion: 3minAya Hirata

Department of Immune Medicine, National

Cancer Center Research InstituteEffect of Imatinib mesylate to tumor immunosuppressive microenvironment

Dec. 14

(Thu.), 201714:25-15:45 Room D

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Toshihiko

Torigoe

Yoshihiro

Hayakawa

100635 3-G-W39-12-P Poster Presentation Madoka TerashimaCenter for iPS Cell Research and Application,

Kyoto University, Kyoto, JapanEstablishment of a pluripotent cell model of Nakajo-Nishimura syndrome

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Systemic autoimmune

disease (3)

Kimito

Kawahata

Shingo

Nakayamada

100636 3-E-W35-7-O/PPresentation: 7min,

Discussion: 3minKoji Tokoyoda

Deutsches Rheuma-Forschungszentrum Berlin

(DRFZ), Berlin, Germany<em>Salmonella</em> remotely suppresses long-lasting humoral immunity

Dec. 14

(Thu.), 201714:25-15:45 Room E

Germinal center reaction and

plasma cellsMasaki Hikida Wataru Ise

100637 3-H-W40-26-P Poster Presentation Hidemitsu TsutsuiNational Center for Global Health and Medicine

Research Institute, Tokyo, Japan

The basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with

microvascular hyperpermeability and leukocyte infiltration

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100638 3-H-W41-14-O/PPresentation: 7min,

Discussion: 3minNaoto Sasaki

Department of Medical Pharmaceutics, Kobe

Pharmaceutical University, Kobe, Japan

Ultraviolet B exposure prevents atherosclerotic cardiovascular disease by regulating

immunoinflammatory responses

Dec. 14

(Thu.), 201714:25-15:45 Room H

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

100639 3-F-W37-11-O/PPresentation: 7min,

Discussion: 2minKamachi Fumitaka

Department of Applied Biological Science,

Faculty of Science and Technology, Tokyo

University of Science, Chiba, Japan

Effects of gut microbial metabolites of linoleic acid on cytokine profuction by immune cellsDec. 14

(Thu.), 201714:25-15:45 Room F Mucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100640 2-B-W20-17-P Poster Presentation Ryota SakaiDepartment of Microbiology and Immunology,

School of Medicine, Keio University, Tokyo,

Japan

Migration Th17 and CCL22/17-CCR4 axis are crucial in the crescentic glomerulonephritis

model

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100641 1-B-W3-4-O/PPresentation: 7min,

Discussion: 2min

Michihiro

Takahama

Institute of Advanced Medical Sciences,

Tokushima University, Tokushima, JapanRAB2B-GARIL5 complex promotes innate immune response against DNA virus

Dec. 12

(Tue.), 201713:20-14:40 Room B

Endogenous innate immunity

and inflammation-1Tatsuya Saitoh Takuya Uehata

100642 1-B-W4-10-P Poster Presentation Yoshihito SudaDepartment of Food, Agricultural and

Environmental Sciences, Miyagi University,

Miyagi, Japan

Expression of complement components, C3 in lung and liver of aging mouseDec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100643 1-I-W17-13-O/PPresentation: 7min,

Discussion: 3min

Fumiko HONDA-

OZAKI

Center for Stem Cell Biology and Regenerative

Medicine Institute of Medical Science University

of Tokyo

Evaluation of the Utility of Induced Pluripotent Stem Cells as a platform for modeling Wiskott

Aldrich Syndrome

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100644 2-B-W20-13-P Poster PresentationMUNENAGA

SHUICHI

Department of Periodontal Medicine, Division of

Applied Life Science, Institute of Biomedical

&amp; Health Sciences, Hiroshima University,

Hiroshima, Japan

Involvement of C5a in the progression of experimental arthritis in SKG mice induced by

<em>Porphyromonas gingivalis </em>infection

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100645 2-G-W23-19-P Poster Presentation Noufa AlonaziPrince Sultan Military Medical City, Riyadh,

Saudi Arabia

The Relationship Between Vitamin D deficiency and the severity of symptoms of Food

Allergy in Children

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100646 2-C-W21-12-O/PPresentation: 10min,

Discussion: 3minYoshihiro Miyahara

Department of Immuno-Gene Therapy, Mie

University Graduate School of Medicine, Mie,

Japan

A novel CAR-T therapy targeting MAGE-A4<sub>p230-239</sub>/HLA-A*02:01 complex

for solid tumors

Dec. 13

(Wed.), 201714:25-15:45 Room C Cell therapy Hiroaki Ikeda Koji Tamada

100647 3-H-W40-3-P Poster Presentation Matsuba ShintaroDepartment of Immunology, School of Medicine,

Kanazawa Medical University, Uchinada, Japan

SLPI negatively regulates LPS-induced eosinophil activation via inhibition of Elk-1

phosphorylation

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallGranulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100648 3-D-W32-5-P Poster Presentation Kiyoshi Yoshimura National Cancer Center, Tokyo, JapanIdentification and analysis about molecules which are highly expressed in pancreatic cancer

stem-like cells

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tumor immunology-1 (Tumor

antigens, antigen presenting

cells, anti-tumor T cells)

Yutaka

Kawakami

Hirokazu

Matsushita

100649 3-H-W41-12-P Poster Presentation Takeru IharaDepartment of Immunology, Faculty of

Pharmaceutical Sciences, Hokkaido UniversityThe role of signal-transducing adaptor protein-1 in Concanavalin A-induced hepatitis

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Tissue-specific immune

diseases IIIKeishi Fujio

Motomu

Hashimoto

29 / 30

The 46th Annual Meeting of The Japanese Society for Immunology Submission ID order

Submission ID Program No. Oral Presentation Time 1st Author Affiliation Title Date Time Venue Session Title Chair1 Chair2

100650 2-G-W23-13-P Poster Presentation Eri SHIMURA Juntendo University, School of Medicine Influence of IL-21 signaling on skin dendritic cellsDec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100651 3-F-W37-10-P Poster Presentation Lisa FujimuraBiomedical Research Center, Chiba University,

Chiba, JapanRoles of enteric neurons in gut mucosal immunity.

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallMucosal-Skin Immunity-3 Eiji Umemoto Jun Kunisawa

100652 3-I-W42-15-P Poster Presentation Hiroaki MachiyamaDeparment of Immunology, Tokyo Medical

University, Tokyo, JapanTCR signaling introduces endocytic machineries at the microclusters

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100653 3-B-W28-6-P Poster Presentation Kato TaikiKitasato University School of

Medicine,Sagamihara,Japan

Tetramer-based analyses of antigen-specific T cells in relapse model of experimental

autoimmune uveoretinitis in mice

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

Hall

Innate Lymphocyte-1 (NKT,

MAIT, gdT, NK)

Kensuke

Shibata

Kazuya

IWABUCHI

100654 1-E-W9-9-P Poster Presentation Arisa MorikawaDepartment of Molecular and Cellular Health

Science, Graduate School of Pharmaceutical

Sciences, Nagoya City University, Nagoya, Japan

Innate immune cells sense Staphylocuccus aureus-derived cysteine protease via their cell

surface molecule(s) to produce proinflammatory cytokines.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100655 1-D-W7-14-P Poster Presentation Toru OkamotoResearch Institute for Microbial Diseases, Osaka

University<strong>Selective TLR ligands stimulate <em>in vivo</em> pathogenicity of JEV</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallVirus infection-1 Taro Kawai

Mitsutoshi

Yoneyama

100656 1-E-W9-16-P Poster Presentation Ryosuke UchiyamaHyogo College of Medicine, Department of

Microbiology, Nishinomiya, Japan

Inflammasome and Fas-mediated IL-1&beta; contributes to Th17/Th1 cell induction in

pathogenic bacterial infection

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Immune response to bacteial

infectionsGoro Matsuzaki Yuki Kinjo

100657 3-I-W42-17-P Poster Presentation Hiroki YatsuDivision of Molecular Pathology, Research

Institute for Biomedical Science, Tokyo

University of Science, Noda, Japan

Regulation Mechanism of Differentiation in Type 1 Helper T cell (T<sub>H</sub>1) and

Follicular Helper T cell (T<sub>FH</sub>) Specific for Influenza A Virus

Dec. 14

(Thu.), 2017

Odd Number / 16:00-17:00,

Even Number / 17:00-18:00

Exhibition

HallT cell-2 : T cell signaling

Satoshi

Matsuda

Tadashi

Yokosuka

100658 2-F-W22-17-P Poster Presentation Yasuo OuchiDepartment of Mucosal Immunology, School of

Medicine, Chiba University, Chiba, Japan

<strong>Generation of tumor antigen-specific CD8<sup>+</sup> T-cells with enhanced

anti-tumor activity via highly efficient CRISPR/Cas9 genome editing</strong>

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

T cell-1: T cell development

and repertoire selection

Taishin

AkiyamaTakeshi Nitta

100659 1-B-W4-16-P Poster Presentation Hiroshi NihiraDepartment of Pediatrics, Faculty of Medicine,

Kyoto University, Kyoto, Japan

Deficiency of adenosine deaminase 2 (DADA2) in Japan: Clinical and genetic diversity in

Japanese patients.

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Endogenous innate immunity

and inflammation-2

Osamu

Takeuchi

Sachiko

Takamura

(Akashi)

100660 3-F-W36-5-O/PPresentation: 7min,

Discussion: 3minTakashi Tanaka

Laboratory for Inflammatory Regulation, REKEN

Center for Integrative Medical Sciences,

Yokohama, Japan

<strong>Microbiota-dependent development of non-alcoholic steatohepatitis (NASH) in

PDLIM2-deficient mice</strong>.

Dec. 14

(Thu.), 201712:50-14:10 Room F Mucosal-Skin Immunity-2 Koji Hase Gyohei Egawa

100661 2-B-W20-19-P Poster Presentation Mari KamiyaDepartment of Rheumatology, Graduate School

of Medical and Dental Sciences, Tokyo Medical

and Dental University (TMDU), Tokyo, Japan

Study of <em>in vitro</em> T cell/myotube interaction disclosed invasive and cytotoxic

nature of CD8<sup>+</sup> cells enclosed in the muscle cells.

Dec. 13

(Wed.), 201716:00-17:00

Exhibition

Hall

Systemic autoimmune

disease (1)

Hitoshi

Kohsaka

Shinsuke

Yasuda

100662 1-I-W17-23-O/PPresentation: 7min,

Discussion: 3minKayoko Sato

Department of Cardiology, Tokyo Women's

Medical University, Tokyo, Japan

Dipeptidyl peptidase 4 (DPP-4) signaling in T cells contributes atherosclerotic development

and podocyte dysfunction

Dec. 12

(Tue.), 201713:20-14:40 Room I Human Immunology Koji Yasutomo Keishi Fujio

100663 1-H-W16-7-O/PPresentation: 6min,

Discussion: 2minNatsuo Yamamoto Department of Infection Control Anti-inflammatory effects on liver cells with flavonoids during rapid phgase in a severe sepsis

Dec. 12

(Tue.), 201714:55-16:15 Room H Cytokines and chemokines-2

Takayuki

Yoshimoto

Takashi

Kobayashi

100664 2-G-W23-14-O/PPresentation: 10min,

Discussion: 3min

Yoshinori

Yamanishi

Department of Immune Regulation, Graduate

School of Medical and Dental Sciences, Tokyo

Medical and Dental University (TMDU), Tokyo,

Japan

Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic

inflammation

Dec. 13

(Wed.), 201714:25-15:45 Room G

Allergy-3 : Allergic dermatitis,

food allergy and allergic

conjunctivitis

Kenji IzuharaTomohiro

Yoshimoto

100665 3-H-W40-27-O/PPresentation: 7min,

Discussion: 3minKensuke Miyake

Department of Immune Regulation, Graduate

School of Medical and Dental Sciences, Tokyo

Medical and Dental University (TMDU), Tokyo,

Japan

Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC

class II complexes from dendritic cells (DCs)

Dec. 14

(Thu.), 201712:50-14:10 Room H Granulocyte & Mast cells Atsuhito Nakao

Yosuke

Kurashima

100666 1-C-W6-8-P Poster Presentation Kaieda Shinjiro Kurume university shcool of medicineInvolvement of CD163-positive Macrophages in the Pathogenesis of Arthritis via Modulation

of Inflammatory Cytokine Expression in the Synovium of a Murine Model

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Tissue-specific immune

diseases II

Naozumi

IshimaruHiroto Tsuboi

100667 1-A-W2-18-P Poster PresentationYOSHIKAWA

SoichiroDepartment of Immune Regulation, Tokyo

Medical and Dental University, Tokyo, Japan

<strong>Prolonged Ca<sup>2+</sup> influx via STIM2 is essential for cytokine-induced IL-

4 production in basophil</strong>

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Tomohiro

YoshimotoRyoji Yagi

100668 1-I-W17-2-P Poster Presentation Saeko ShimoderaDepartment of Pediatrics, Kyoto University

Graduate School of Medicine, Kyoto, Japan

A first case of hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by a large

<em>UNC13D</em> gene duplication

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

HallHuman Immunology Koji Yasutomo Keishi Fujio

100669 1-F-W11-10-P Poster Presentation Takuma ISSHIKIDepartment of Immunology, Juntendo University

School of Medicine, Tokyo, JapanAnti-TIM-3 treatment exacerbates pulmonary inflammation and fibrosis in mice

Dec. 12

(Tue.), 2017

Odd Number / 16:30-17:30,

Even Number / 17:30-18:30

Exhibition

Hall

Combination cancer

immunothrapy -beyond

immune checkpoint inhibitors-

Hiroyoshi

Nishikawa

Yoshihiro

Hayakawa

30 / 30