the “analysome”
DESCRIPTION
High Level Implementation Timeline. Business Case. Unmet Need. Value Proposition. The “Analysome”. Shared p roject requirements: p roject a nalyst , platform pilot, socialization, service implementation & Curation Project value for stakeholders: - PowerPoint PPT PresentationTRANSCRIPT
The “Analysome”
Unmet Need
Drug R&D requires validated biomarker assays Information on such assays is available but is neither
well coordinated nor vetted Significant time/money is spent researching the
availability & quality of biomarkers Drug companies need to reduced the costs of
searching for biomarker assays (e.g. $30K to $40K) CROs need a showcase to display their biomarker
capabilities for maximum impact to multiple potential users
Academics need a simple way to find opportunities to seek new, useful biomarkers
Value Proposition
The Analysome will accelerate life-science R&D including translational research by: Building an evidence-based database of assays for
analytes Standardizing knowledge & vocabulary for analyte use
& assay validation Allowing life scientists to find & utilize the best
biomarkers for their research. Allowing biomarker & diagnostic developers to
understand assay availability, use & cost in the market
Fostering a community of scientific users, biomarker developers & assay service organizations
Shared project requirements: project analyst, platform pilot, socialization, service implementation & Curation
Project value for stakeholders: FTE saving on finding the right biomarker at the right time with the right quality and the right
availability FTE saving on in-house curation of biomarker resources providing vendors a marketplace for their
assays Risk mitigation – using appropriately validated & qualified biomarkers minimizes experimental and
regulatory risks
High Level Implementation Timeline
Q2 - 13 Q4 - 13 Q4 - 14Q2 - 14
Workstream Start
Business Case
Business Case Funding Agreed
Business Case Funding Available
Biomarker Service Available
1
Prioritized list of platforms from U-BIOPRED
Vision of the Analysome Service
What does the Analysome Service look like when it’s available?• On-line, PA-branded service, providing access
to information about the availability of assays for human analytes.
• Search by analyte (gene, protein, metabolite)• Expanded search by biological
pathway/network• Results delivered as list of available assays
– Key parameters (sensitivity, multiplexing, cost, validation status…)
– Provider2
Web Portal “Analysome” – Functional Model
Ability to select the
matrix
Validation qualifiers
e.g.Commercial, academic
Currently> 70.000 assays in
test system
Ability to select the
matrix
Direct link to assay provider
1= Research assay not fully validated for this matrix and/or most 2= Validated research assay and most >LLoQ, supplier’s validation data not in peer-review paper3= Validated research assay and most >LLoQ, validation in peer-reviewed paper4= Validated (approved by FDA or other) diagnostic assay and high proportion >LLoQ, validation in peer-reviewed paper
Working prototype demonstration of the Analysome is available on YouTube @
https://www.youtube.com/watch?v=o_14ViKsAWE&feature=youtu.be
Key Stakeholders
• Provider side– Assay providers (e.g. companies who
sell kits / who offer assay services)– CROs (note the relationship between
original providers and the ‘appliers’)• Consumer side
– Translational Research, Biomarker Discovery• pharma, biotech, academia, non-profit
research organisations– CROs (see above) 4
Value Proposition
For consumers• One stop shopping: Rapidly find available
assays for analytes of interest (including analytes in related biological networks)
For providers• Highly effective marketing channel
Value proposition for both sides hinges on completeness of the list of available assays
5