the biotech for natural...
TRANSCRIPT
THE BIOTECH FOR NATURAL
PRODUCTS
1. BIOALVO: WHO WE ARE
• BIOALVO was founded in 2006 as a drug discovery company with own pipeline of drugs against
neurological disorders
• Proprietary discovery technology based in yeast (GPS D2) + unique microbial natural extract
libraries from Portuguese ecosystems (mostly marine)
• In late 2010 BIOALVO has repositioned its strategy using its assets to a broader range of
industry/academia partners:
• Pharma, Cosmetics, nutraceutical, industrial processes…
• In 2011 BIOALVO presents itself as “The Biotech for Natural Products”
• Today: major focus in exploring the power of its assets: - technology to screen novel bioactivities for different industry/academia partner - providing access to its libraries for partners to screen in house or with us - developing its own new natural ingredients (botox-like; anti-UV; anti-oxidant; neuroprotection)
THE UNLIMITED BIOACTIVE POTENTIAL OF PORTUGUESE SEA
1. BIOALVO: WHO WE ARE
PORTUGAL has one of the largest continental shelf’s and is the central point between 3 major continents: America, Africa and Europe. Marine microorganisms: Overcoming supply limitations associated with plant and animal derived natural products
Although oceans are 70% of the EARTH surface
LESS THAN 5% OF MARINE BIODIVERSITY ARE INCORPORATED INTO SERVICES AND PRODUCTS
LIBRARIES: DIFFERENT PRODUCTS FROM PORTUGUESE NATURE Libraries of microorganisms from unique and exclusive spots in the Portuguese Ecosystem (hydrothermal vents, mines, deep subseafloor, intertidal…) In this context, BIOALVO has developed or is developing 3 subsets with a total of 90 000 samples: ONE OF THE BIGGEST COLLECTIONS:
- PharmaBUG - LUSOEXTRACT 2010 - LUSOMAREXTRACT 2011
2. BIOALVO: WHAT DO WE BRING
Menez Gwen Lucky Strike Rainbow Saldanha
THE GPS D2 TECHNOLOGY • Applications designed include
o Anti-inflammatory
o Anti-UV (A/C)
o Anti-bacterial
o Neuroprotection (AD and PD) o Cosmetic specific pathways
o Enzymatic modulators…
• Robotic Unit with capacity for screening around 10,000 cpds a week
- performed over 200 screenings
- operates for internal programmes as well as for clients
- Perkin-Elmer Janus Liquid Handler; LiCONic STX40 incubator,
Perkin-Elmer VICTOR D plate reader
0
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0,8
1
1,2
0 10 20 30 40 50 60 70 80
Time (h)
OD
595
BLOCKADE 10 uMBLOCKADE 5 uMBLOCKADE 2,5 uM BLOCKADE 1 uMBLOCKADE 0 uMWT 10 uM
2. BIOALVO: WHAT DO WE BRING
THE UPSCALE CAPACITY • Upscale capacity up to Pilot Scale
o 1-10L
o 300L
o Downstream processing
o Several batches up to hundreds of gr produced
o Microbiology Quality Control of batches
2. BIOALVO: WHAT DO WE BRING
A UNIQUE COMBINATION
ONE-STOP SHOP FOR NEW BIOACTIVE IDENTIFICATION & RESSUPLY
2. WHAT DO WE BRING: OUR ADVANTAGES
THE POWER OF OUR APPROACH EXAMPLES OF SUCCESS
Challenge:
Identify novel and potent Anti-wrinkle
active ingredients in
BIOALVO’s libraries
EXAMPLES
New Marine Botox: an ingredient from BIOALVO’s libraries
• Being developed by BIOALVO • Strain isolated from the Rainbow
hydrothermal vent (Azores islands), species undisclosed, located at 2290m depth.
• Local temperature is 3.8 ºC.
EXAMPLES
FROM THE DEEP ATLANTIC RAINBOW TO YOUR SKIN - RefirMARINE™The Mid-Atlantic Ridge (MAR), that extends from the Arctic Ocean to the African Continent, is mainly constituted
by submerged mountains and harbors several hydrothermal fields such as Menez Gwen, Menez Hom, Rainbow, Lucky Strike and Mount Saldanha. A new bacterial strain from Schewanella sp was
isolated from one of these extreme vents, at and characterized. We expected that this bacteria has developed several protection mechanisms for the harsh conditions
and local competition for the rare nutrients available. Indeed, by laboratory
adapted fermentation we could recover metabolites that together act as very potent muscle contraction inhibitors.
This defensive function in nature was adapted to cosmetic applications and this extract is the basis of the RefirMARINE™ ingredient - a potent anti-wrinkle and expression lines
attenuator comparable to other injectable solutions.
RefirMARINE™ Cosmetic benefits: reduction of expression lines and wrinkles, and moisturizing with topical
application.
RefirMARINE™
• Anti-wrinkle activity:
o Transient marine botulinum toxin natural bio-similar
o Exclusive and unique o New Mode of Action
• Phylogenetically similar to other isolates
NATIONAL PHARMACEUTICAL GROUP (undisclosed) selected BIOALVO for its next innovative Anti-infectious drug
3. EXPLORING NEW MARKETS
A MARKET OPPORTUNITY FOR NATURAL PRODUCTS NATURAL PRODUCTS: US$ 40-60 BILLION ANNUAL
MARINE BIOTECH: US$ 4.1 BILLION BY 2015, MORE THAN 10% GROWTH RATE
NATURAL COSMETICS PRODUCTS: US$ 2 BILLION IN 2010, 20% GROWTH RATE
The new GREEN is BLUE!!!
Cosmetics
Nutraceuticals
Wholesale, textiles
Household products
Pharmaceuticals …
BIOALVO looks for:
Partners that have raw materials/libraries/ingredients that do not have yet a bioactivity assigned GPSD2 technology tool
Partners that have assays or desired bioactivity but have no samples PharmaBUG Library ( > 490 extracts)
LUSOEXTRACT Library ( > 4000 extracts) LUSOMAREXTRACT Library (under construction)
Partners that wish to share risk and development costs of novel ingredients Joint-Development
RTD projects where BIOALVO can clearly gain funding advantages
3. EXPLORING NEW MARKETS
3. EXPLORING NEW MARKETS: USA ENTRY
EU MARKET
USA MARKET
USA BUT HOW DO YOU ENTER???
3. EXPLORING NEW MARKETS: USA ENTRY
OPPORTUNITIES 1. SIZE – HOW DO YOU
MANAGE DEMAND? 2. DIVERSITY – WHO IS THE
RIGHT PARTNER?
3. FRIENDLY REGULATORY/BUSINESS ENVIRONMENT
4. ENTRY BY JOINT-VENTURES? ACQUISITIONS? OPERATIONAL BRANCH?
RISKS AND BARRIERS 1. NOT LOCAL – NO TRUST
2. EUROPEAN AND PORTUGUESE PERCEPTION – CRISIS & VALIDATION
3. EXTERNAL SUPPLY CHAIN – FORCING ENTRY
4. EXTENSIVE GEOGRAPHICAL REACH
3. EXPLORING NEW MARKETS: USA ENTRY
• HARD SCHEDULE
• REALLY BIG COMPANIES
• SOME THOUGH PITCHS
We started BIG! NY - Times Square and 5th Avenue!
3. EXPLORING NEW MARKETS: USA ENTRY
3. EXPLORING NEW MARKETS: USA ENTRY
3. EXPLORING NEW MARKETS :USA ENTRY
TEXAS THE REAL TRUE FEELING OF COWBOYS!
3. EXPLORING NEW MARKETS :USA ENTRY
3. EXPLORING NEW MARKETS :USA ENTRY
MAIN INPUT: 1. QUALITY STAMP to selected projects
2. GUIDANCE in DEVELOPING BD CASE SHOW
3. LOWER THE “NOT LOCAL” RISK – ACT AS LOCAL TRUSTEE
4. USA IS SMALLER WITH US CONNECT
5. MARKET ORIENTED!
IN THE END WE GOT THE DEALS!!!!
THANK YOU SO MUCH FOR ALL YOU HAVE DONE FOR BIOALVO!
BIOALVO’s CONTACTS
Management, Supervision and main contact: HELENA VIEIRA ([email protected]) Edifício ICAT, Campus da FCUL Campo Grande 1749-016 Lisboa Tel: +351 217500101 www.bioalvo.com http://www.facebook.com/Bioalvo