Discovery Sciences

Janssen’s CL 2016+ Upgrade Project:

From Starfish to Octopus

Inge MoelansSLAS Berlin 15 March 2017

Discovery Sciences

Global Compound Logistics Centers

Spring House, PA

La Jolla, CA

Beerse, Belgium

External Storage Provider

Dry Compound samples: ± 1,000,000DMSO samples – tubes: > 2,300,000DMSO samples – plates: > 4,000 384-well plates

Discovery Sciences

From the Basement to the World:How Compound Logistics Facilitates Drug Discovery

Discovery Sciences

Daily Global CL Roles & Responsibilities

High Quality

Compound Collection

Storage

RetrievalDistribution

1. Responsible for Storage, Retrieval and Distribution of the J&JProprietary Compound Collection: In-house synthesized compounds Compound purchases/exchanges/collaborations

2. Provide sample and plate production in support of (highthroughput) screening efforts and Drug Discovery (TA) projects

3. Quality control of Corporate J&J Compound Collection(internal & external)

Global Compound Logistics

ESPDS

Screening Teams

TAs

CRO

Medicinal Chemistry

Compound Vendors

External Collaborator

IC

IT

Legal

CBSSafety

Legal Patent

Discovery Sciences

Operational efficiency

Cost effective

Customer satisfaction

Global Compound Logistics LandscapeProvide flawless operations for all compound/sample flows and processes

1) Global Ordering & Fulfillment Processes for all Compound Flows (compound weighing, solubilizations and plate replication).

2) Global compound/library flows/processes and requests (IMI, Keystone…)

3) Global QC processes

4) Global Registration of (externally) synthesizedcompound samples

5) Global Compound Clearance Processes.

General Management &

Projects

Registration

Check-in

Weighing dry compound

samples

Solubilization dry compounds

Sample storage processes

Plate production processes

Quality Control

Compound

Clearance

Shipments

General Management &

Projects

Discovery Sciences

Requestors Recipients

Key Operations

Compound LogisticsCompound samples

(internal/external)

Registration, Submission, Check-in GCRS

Internal

External

QC database

Global Ordering & Fulfillment System - MOSAIC

Patent & Legal Compliancy

NEAT STORAGE

SOLUBILIZE(MOTHER) PLATE

DISPENSING

ASSAY-READY PLATE

DISPENSING

MOTHER PLATE

STORAGE

NEAT DISPENSE

STOCK SOLUTION DISPENSING

STOCK SOLUTION STORAGE

QC

QC

Compound Clearance ProcessesCLAMS

Compound Contractual StatusCCC

Discovery Sciences

VISIONCompound Logistics is a state-of-the-art

Global Organisation that cares for the Janssen Compound Library and flawlessly feeds all

Janssen Compound Related (early) Research Activities (internally as well as externally) with

high quality compound samples in a standardized manner

Discovery Sciences

Compound Logistics Pre-2013

FCBD

ECHO Platform

ABCD COATS

Discovery Sciences

Compound Logistics Pre-2013

FCBD

ECHO Platform

ABCD COATS

Different processes

Compound flow 1

Com

pound f

low

2

Rules

Structures

Software application X

Soft

war

e ap

plic

atio

n Y

Sto

rag

e c

on

dit

ion

sResponsibilities

DM

SO C

on

cen

trat

ion

5 m

M

DMSO Concentration 10 mM

DMSO Concentration 20 mM

DMSO Concentration 10 mM

Qu

ality

Co

ntr

ol

LC/MS

qNMR

CLND

Roles

Library flowsTechnology Platforms

Glo

bal

Local

Hard

ware

Support

Database

Barcod

e r

an

ge

Shipments

-20C

+4C

RT?

LabelsMicronic tubes

Matrix tubes

Matr

ical

tub

es

Inventory

Plate layouts

Co

mm

un

icati

on

Qu

ality

QC

Maintenance

Labware

Plate layouts

IT

Metrics

Plate types

Files

Automation

Discovery Sciences

Inventory Tracking

Ordering

Sample Processing

Laboratory Automation Integration

Tracked Shipping

Connectivity

Mosaic: More than just an ordering system...

Discovery Sciences

Global Compound Logistics MOSAIC

June 2010 : First contact between Janssen & Titian

June 2011 : First FS draft

March 2012 : Finalisation of Beerse FS

May 2012 : Janssen management aims for global implementation

March 2013 :Finalisation of global FS

April 2013 : First UAT version at Beerse

December 2013 : Beerse goes live with Mosaic

September 2014: Implementation Mosaic in LJ and SH

April 2015: Implementation GROS globally

Discovery Sciences

2001

20022003

20042005 2006

2007

2008

2009

2010

20112012

20132014

2015

20162017

20182019

2020

2016+

Discovery Sciences

1. Provide flawless operations for all compound/sample flows and

processes globally.

2. Commit to maintaining/implementing state-of-the art infrastructure

that ensures short cycle times in internal and external Lead

Discovery efforts without compromising the quality of the compound

samples.

3. Improve quality of global compound collection.

4. Establish efficient IT applications for ordering & fulfillment

processes.

Goals & Objectives

Discovery Sciences

1. Provide flawless operations for all compound/sample flows and

processes globally.

2. Commit to maintaining/implementing state-of-the art infrastructure

that ensures short cycle times in internal and external Lead

Discovery efforts without compromising the quality of the compound

samples.

3. Improve quality of global compound collection.

4. Establish efficient IT applications for ordering & fulfillment

processes.

Goals & Objectives

Discovery Sciences

Compound Logistics 2016+ Upgrade Project Different WORKSTREAMS (WS)

WS 1

WS 2WS 3

WS 5.1

WS 4

WS 5.2

WS 6

WS 7Key Team Members

Cross-functional team sponsored by Discovery Sciences-Lead Discovery

Finance, EHS, Compound Logistics, Procurement, Worldwide Engineering, GBO, CBS lab ops, IT & Screening

Discovery Sciences

Compound Logistics 2016+ Upgrade Project Different WORKSTREAMS (WS)

DRY Stock & PROCESSES

Liquid Stock & PROCESSES

Facilities

IT

Reagent Ordering & Tracking Service

Discovery Sciences

Higher efficiency, global leverage and flexible capacity

Hardware Systems:

Improvement Global Sample Storage Systems

Renewal liquid handler parks (µ-Liter transfer)

Implementation of a new technology platforms for the preparation of (assay-ready) compound plates (-Liter transfer)

Renovation of lab space

Improvement equipment LC/MS/QC/QA processes

Informatics Systems:

Process overview dash board

Roll-out of a (new) global QC database (QCMart)

Optimization Global Registration Systems

New IT system to support Compound Clearance Processes

MOSAIC enhancements & performance improvement

Identified priority actions:

1. Improved quality

2. Reduced cycle times

3. Standardization equipment platforms

4. Centralization Dry Stock management

Automation must be fast, flexible and efficient

Discovery Sciences

TM 5TM 3

Program Team CL

Project Leader: Inge M

TM 1

Project Sponsor

Dry Stock

TM 2

Liquid Stock CL LIMS Space & Facilities

TM 4

ROATS

Steering CommitteeCore Business

Services

LEAD

HTSCL

IT

TM 1

TM 2 TM 3 TM 4

TM 5

CoachPartner/back-up CBS

Discovery Sciences

CL+ Upgrade 2017-2018Improve Quality

Expand Capacity

Speed-up Delivery Times

StandardizeGlobal Processes & Compound Flows

Space & facilities improved environmental conditions

Centralization Dry Stock External Storage Provider

MIO upgrade

Storage systems: Upgrade Haystack Tube Storage System: Project Guylian

Upgrade Jukebox Plate Storage System

New Storage System Plates & Tubes: Project Whale

µ-Liter Liquid Handling Platforms: Project Starfish

-Liter Liquid Handling Platforms: Project Octopus +

Discovery Sciences

Discovery Sciences

Global Compound Logistics MOSAIC

June 2010 : First contact between Janssen & Titian

June 2011 : First FS draft

March 2012 : Finalisation of Beerse FS

May 2012 : Janssen management aims for global implementation

March 2013 : Finalisation of global FS

April 2013 : First UAT version at Beerse

December 2013 : Beerse goes live with Mosaic

September 2014: Implementation Mosaic in LJ and SH

April 2015: Implementation GROS globally

March 2017: Implementation MOSAIC GOFS MIO

Discovery Sciences

MOSAIC Improvements

The MOSAIC Global Ordering and Fulfillment System has recently (10 September) successfully been migrated to the new Software Defined Data Center (SDDC)

SDDC is the new J&J “fully virtualized” Data Center setup instead of the legacy datacenters (Singapore, Raritan & Beerse)

Titian released the Multi Instance Ordering (MIO) version of Mosaic

Global CL will move from Single Instance Ordering (Beerse) to MIO in week 12 2017 (Singapore, Raritan & Beerse)

Better performance of MOSAIC system in Spring House and La Jolla (ordering and fulfillment processes)

Upgrade will allow us to upscale the local fulfillment capabilities in Spring House and La Jolla

MIO will facilitate deployment of an integrated Asia-Pacific CL team

Sample Management System

Discovery Sciences

Hamilton ASM Plate Storage System Upgrade

• Extra storage module (+/- 2000 plates)

• Module will be the third one and installed on the left.

• Keeps plates @ 20°C and a relative humidity of 5%

• IMS monitoring

JukeBox MOTHER PLATE STORAGE

Discovery Sciences

STOCK SOLUTION STORAGE

Haystack Tube Storage System Upgrade

• Buffer upgrade: increase throughput (unattended operation overnight)

• Recap all tubes: remove hard plastic caps, put soft rubber caps in place

• Change for SBS footprint racks (now we are using non standard tube racks)

GuyLian

Discovery Sciences

MOTHER PLATE STORAGE

STOCK SOLUTION STORAGE

Tube/Plate storage system

Can store plates and tubes in the same environmental conditions (20°C, 5-10% relative humidity)

Will contain a copy of the Global HTS Library for the Octopus platforms

Will contain tubes of solubilized compounds for local Hit to Lead and Lead Optimization. When HtL & LO project is finished, these tubes will move to the Haystack Storage System(Beerse)

Whale

Discovery Sciences

SOLUBILIZE(MOTHER) PLATE

DISPENSINGSTOCK SOLUTION

DISPENSING

Starfish

• The Starfish platform consists of a pipettor, a Logistics Cabinet and a Track Gripper module.

• Ability to cherry-pick from tubes into plates

• Serialization compound samples for dose-response plates

• Ability to add controls• Run unattended over/night• Keeps source compound racks/plates in

controlled environment• Integration with MOSAIC

Discovery Sciences

ASSAY-READY PLATE

DISPENSING

MOTHER PLATE STORAGE

Octopus

• 384/1536 assay-ready plate Platform• Ability to plate 1M samples at a single

concentration in 5 days• Ability to add controls• Ability to swap equipment on carts or

docks• Run unattended over/night• Keeps source compound plates in

controlled environment• Integration with MOSAIC

Discovery Sciences

Stakeholder Management

CL Dry Stock (ESP)

CL LIMS

2017 2018

SH - Facilities

SH - Octopus 1

SH - Starfish 2

SH – Whale 1

BE - Facilities

BE - Starfish (1 & 3)

BE - Octopus 2

BE - Guylian

BE - JukeBox extension

LJ - Facilities

LJ - Octopus mini 3

LJ - Starfish 4

LJ - Whale 2

Discovery Sciences

The Compound Logistics (CL) WILL deliver a Global standardized solution for CL in conjugation with the Global Screening

Platform/Team and TAs to optimally support Drug Discovery Goals!

Improvement Dry stock & Processes & Quality; Reagent Ordering &

Tracking Service

Improvement Liquid stock & Processes & Quality

Standardization/harmonization of CL processes and Compound flows

Investments in (new) hardware & software systems

Renovation of lab space

Common investment areas at the 3 sites (BE, SH & LJ)

Improved turnaround times

SUMMARY

Discovery Sciences

One Global team … Many key challenges

Discovery Sciences

Discovery Sciences

Improving performance and exploiting new technologies to solve tomorrow's challenges.

Conny SterckxMichel Oris

Roel CuylaertsAnn Janssens

Anja VerhoevenLinda Aerts

Freddie LauwersRaf Benoy

Danny BellensHannelore Cauwenbergh

Danielle Van Beers

Rudy Loozen

Sarah KaufholdRose Dandridge

Lou LoccoErin Egan

Tanya KueiCorbin OcchinoKristen Nailor

Teresa Ng

Jim EdwardsPeter Roevens

Lieven Meerpoel

Jeroen JespersJan MertensJohn HansenBart Peeters

Leen ClaessensStefanie Schomaker

Koen GorisCarl Peten

Danny VerbinnenPatrick MarichalSteven French

Bryan ScottJoe Terzo

Peter Tummino

THINK GLOBAL, ACT LOCAL!!!

Christophe BuyckMark Seierstad

Tara Mirzadegan

Karien PeetersChristophe Verbruggen

Pieter Vandersteen

Jan Voeten, Serge Pauwels, Peter Dekens, Margot Francken, Andrew Toskovich, Sonia PerezFrancine Strollo, Blossom Loo, Koen Demoen, Al

Boylan, Bob Van Den Poel, Ellyn Ensby, Rody Mc Kenna, ….

Joe KwasnoskiJoe Palutis

Edmund Graf

Samantha AllenMike WeberKevin Lumb