the cardiovascular system: part b: the heart:. depolarization of the heart is rhythmic and...
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The Cardiovascular System: Part B: The Heart:
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Depolarization of the heart is rhythmic and spontaneous
About 1% of cardiac cells have automaticity— (are self-excitable)
Gap junctions ensure the heart contracts as a unit
Long absolute refractory period (250 ms)
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Intrinsic cardiac conduction system◦ A network of noncontractile (autorhythmic) cells
that initiate and distribute impulses to coordinate the depolarization and contraction of the heart
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1. Sinoatrial (SA) node (pacemaker)
◦ Generates impulses about 75 times/minute (sinus rhythm)
◦ Depolarizes faster than any other part of the myocardium
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2. Atrioventricular (AV) node
◦ Smaller diameter fibers; fewer gap junctions
◦ Delays impulses approximately 0.1 second
◦ Depolarizes 50 times per minute in absence of SA node input
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3. Atrioventricular (AV) bundle (bundle of His)
◦ Only electrical connection between the atria and ventricles
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4. Right and left bundle branches
◦ Two pathways in the interventricular septum that carry the impulses toward the apex of the heart
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5. Purkinje fibers
◦ Complete the pathway into the apex and ventricular walls
◦ AV bundle and Purkinje fibers depolarize only 30 times per minute in absence of AV node input
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Copyright © 2010 Pearson Education, Inc. Figure 18.14a
(a) Anatomy of the intrinsic conduction system showing the sequence of electrical excitation
Internodal pathway
Superior vena cavaRight atrium
Left atrium
Purkinje fibers
Inter-ventricularseptum
1 The sinoatrial (SA) node (pacemaker)generates impulses.
2 The impulsespause (0.1 s) at theatrioventricular(AV) node. The atrioventricular(AV) bundleconnects the atriato the ventricles.4 The bundle branches conduct the impulses through the interventricular septum.
3
The Purkinje fibersdepolarize the contractilecells of both ventricles.
5
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Defects in the intrinsic conduction system may result in
1. Arrhythmias: irregular heart rhythms
2. Uncoordination of atrial and ventricular contractions
3. Fibrillation: rapid, irregular contractions; useless for pumping blood
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Heartbeat is modified by the Autonomic Nervous System
Cardiac centers are located in the medulla oblongata
◦ Cardioacceleratory center innervates SA and AV nodes, heart muscle, and coronary arteries through sympathetic neurons
◦ Cardioinhibitory center inhibits SA and AV nodes through parasympathetic fibers in the vagus nerves
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Copyright © 2010 Pearson Education, Inc. Figure 18.15
Thoracic spinal cord
The vagus nerve (parasympathetic) decreases heart rate.
Cardioinhibitory center
Cardio-acceleratorycenter
Sympathetic cardiacnerves increase heart rateand force of contraction.
Medulla oblongata
Sympathetic trunk ganglion
Dorsal motor nucleus of vagus
Sympathetic trunk
AV node
SA nodeParasympathetic fibersSympathetic fibersInterneurons
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Electrocardiogram (ECG or EKG): a composite of all the action potentials generated by nodal and contractile cells at a given time
Three waves1. P wave: depolarization of SA node2. QRS complex: ventricular depolarization3. T wave: ventricular repolarization
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Copyright © 2010 Pearson Education, Inc. Figure 18.16
Sinoatrialnode
Atrioventricularnode
Atrialdepolarization
QRS complex
Ventriculardepolarization
Ventricularrepolarization
P-QInterval
S-TSegment
Q-TInterval
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Copyright © 2010 Pearson Education, Inc. Figure 18.17
Atrial depolarization, initiatedby the SA node, causes theP wave.
P
R
T
QS
SA node
AV node
With atrial depolarizationcomplete, the impulse isdelayed at the AV node.
Ventricular depolarizationbegins at apex, causing theQRS complex. Atrialrepolarization occurs.
P
R
T
QS
P
R
T
QS
Ventricular depolarizationis complete.
Ventricular repolarizationbegins at apex, causing theT wave.
Ventricular repolarizationis complete.
P
R
T
QS
P
R
T
QS
P
R
T
QS
Depolarization Repolarization
1
2
3
4
5
6
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 1
Atrial depolarization, initiated bythe SA node, causes the P wave.
P
R
T
QS
SA node Depolarization
Repolarization
1
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 2
Atrial depolarization, initiated bythe SA node, causes the P wave.
P
R
T
QS
SA node
AV node
With atrial depolarization complete,the impulse is delayed at the AV node.
P
R
T
QS
Depolarization
Repolarization
1
2
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 3
Atrial depolarization, initiated bythe SA node, causes the P wave.
P
R
T
QS
SA node
AV node
With atrial depolarization complete,the impulse is delayed at the AV node.
Ventricular depolarization beginsat apex, causing the QRS complex.Atrial repolarization occurs.
P
R
T
QS
P
R
T
QS
Depolarization
Repolarization
1
2
3
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 4
Ventricular depolarization iscomplete.
P
R
T
QS
Depolarization
Repolarization
4
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 5
Ventricular depolarization iscomplete.
Ventricular repolarization beginsat apex, causing the T wave.
P
R
T
QS
P
R
T
QS
Depolarization
Repolarization
4
5
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Copyright © 2010 Pearson Education, Inc. Figure 18.17, step 6
Ventricular depolarization iscomplete.
Ventricular repolarization beginsat apex, causing the T wave.
Ventricular repolarization iscomplete.
P
R
T
QS
P
R
T
QS
P
R
T
QS
Depolarization
Repolarization
4
5
6
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Copyright © 2010 Pearson Education, Inc. Figure 18.17
Atrial depolarization, initiatedby the SA node, causes theP wave.
P
R
T
QS
SA node
AV node
With atrial depolarizationcomplete, the impulse isdelayed at the AV node.
Ventricular depolarizationbegins at apex, causing theQRS complex. Atrialrepolarization occurs.
P
R
T
QS
P
R
T
QS
Ventricular depolarizationis complete.
Ventricular repolarizationbegins at apex, causing theT wave.
Ventricular repolarizationis complete.
P
R
T
QS
P
R
T
QS
P
R
T
QS
Depolarization Repolarization
1
2
3
4
5
6
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Copyright © 2010 Pearson Education, Inc. Figure 18.18
(a) Normal sinus rhythm.
(c) Second-degree heart block. Some P waves are not conducted through the AV node; hence more P than QRS waves are seen. In this tracing, the ratio of P waves to QRS waves is mostly 2:1.
(d) Ventricular fibrillation. These chaotic, grossly irregular ECG deflections are seen in acute heart attack and electrical shock.
(b) Junctional rhythm. The SA node is nonfunctional, P waves are absent, and heart is paced by the AV node at 40 - 60 beats/min.
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Two sounds (lub-dup) associated with closing of heart valves
◦ First sound occurs as AV valves close and signifies beginning of systole
◦ Second sound occurs when SL valves close at the beginning of ventricular diastole
Heart murmurs: abnormal heart sounds most often indicative of valve problems
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Copyright © 2010 Pearson Education, Inc. Figure 18.19
Tricuspid valve sounds typically heard in right sternal margin of 5th intercostal space
Aortic valve sounds heard in 2nd intercostal space atright sternal margin
Pulmonary valvesounds heard in 2ndintercostal space at leftsternal margin
Mitral valve soundsheard over heart apex(in 5th intercostal space)in line with middle ofclavicle
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Cardiac cycle: All events associated with blood flow
through the heart during one complete heartbeat
◦ Systole—contraction
◦ Diastole—relaxation
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1. Ventricular filling—takes place in mid-to-late diastole
◦ AV valves are open
◦ 80% of blood passively flows into ventricles
◦ Atrial systole occurs, delivering the remaining 20%
◦ End diastolic volume (EDV): volume of blood in each ventricle at the end of ventricular diastole
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2. Ventricular systole
◦ Atria relax and ventricles begin to contract ◦ Rising ventricular pressure results in closing of
AV valves◦ Isovolumetric contraction phase (all valves are
closed)◦ In ejection phase, ventricular pressure exceeds
pressure in the large arteries, forcing the SL valves open
◦ End systolic volume (ESV): volume of blood remaining in each ventricle
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3. Isovolumetric relaxation occurs in early diastole
◦ Ventricles relax◦ Backflow of blood in aorta and pulmonary trunk
closes SL valves and causes dicrotic notch (brief rise in aortic pressure)
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Volume of blood pumped by each ventricle in one minute
CO = heart rate (HR) x stroke volume (SV)
◦ HR = number of beats per minute◦ SV = volume of blood pumped out by a ventricle
with each beat
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At rest◦ CO (ml/min) = HR (75 beats/min) SV (70 ml/beat) = 5.25 L/min
◦ Maximal CO is 4–5 times resting CO in nonathletic people
◦ Maximal CO may reach 35 L/min in trained athletes
◦ Cardiac reserve: difference between resting and maximal CO
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Sympathetic nervous system is activated by emotional or physical stressors
◦ Norepinephrine causes the pacemaker to fire more rapidly (and at the same time increases contractility)
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Parasympathetic nervous system opposes sympathetic effects ◦ Acetylcholine hyperpolarizes pacemaker cells by
opening K+ channels The heart at rest exhibits vagal tone
(parasympathetic)
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1. Hormones◦ Epinephrine from adrenal medulla enhances
heart rate and contractility
◦ Thyroxine increases heart rate and enhances the effects of norepinephrine and epinephrine
2. Intra- and extracellular ion concentrations (e.g., Ca2+ and K+) must be maintained for normal heart function
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Age Gender Exercise Body temperature
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Tachycardia: abnormally fast heart rate (>100 bpm)◦ If persistent, may lead to fibrillation
Bradycardia: heart rate slower than 60 bpm◦ May result in grossly inadequate blood circulation◦ May be desirable result of endurance training
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Progressive condition where the CO is so low that blood circulation is inadequate to meet tissue needs
Caused by◦ Coronary atherosclerosis◦ Persistent high blood pressure◦ Multiple myocardial infarcts◦ Dilated cardiomyopathy (DCM)
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Congenital heart defects
◦ Lead to mixing of systemic and pulmonary blood◦ Involve narrowed valves or vessels that increase
the workload on the heart
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Copyright © 2010 Pearson Education, Inc. Figure 18.24
Occurs inabout 1 in every500 births
Occurs inabout 1 in every 1500 births
Narrowedaorta
Occurs inabout 1 in every 2000births
Ventricular septal defect.The superior part of the inter-ventricular septum fails to form; thus, blood mixes between the two ventricles. More blood is shunted from left to right because the left ventricle is stronger.
(a) Coarctation of the aorta. A part of the aorta is narrowed,increasing the workload of the left ventricle.
(b) Tetralogy of Fallot. Multiple defects (tetra = four): (1) Pulmonary trunk too narrow and pulmonary valve stenosed, resulting in (2) hypertrophied right ventricle; (3) ventricular septal defect; (4) aorta opens from both ventricles.
(c)
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Sclerosis and thickening of valve flaps
Decline in cardiac reserve
Fibrosis of cardiac muscle
Atherosclerosis