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1 Cells "Long ago it became evident that the key to every biological problem must finally be sought in the cell; for every living organism is, or at some time, has been a cell." E.B. Wilson 2003/2004 Cells: The Basic Units of Life 2 The Cell Theory The cell theory united plant and animal sciences by recognizing that the cell is the fundamental component of all living organisms, from orchids and earthworms to human beings. 2003/2004 Cells: The Basic Units of Life 3 But what is a cell? An enclosure l Boundary l Interior region l Hereditary store 2003/2004 Cells: The Basic Units of Life 4 Contributors to the Cell Theory: § Robert Hooke (named cells) § Anton Van Leeuwenhoek (saw microorganisms) § Robert Brown (discovered the nucleus) § Matthias Schleiden (plants are made of cells) § Theodor Schwann (animals are made of cells) § Rudolf Virchow (cells come from cells)

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Cells"Long ago it became evident that the key to every biological problem must finally be sought in the cell; for every living organism is, or at some time, has been a cell."E.B. Wilson

2003/2004Cells: The Basic Units of Life2

The Cell Theory

The cell theory united plant and animal sciences by recognizing that the cell is the fundamental component of all living organisms, from orchids and earthworms to human beings.

2003/2004Cells: The Basic Units of Life3

But what is a cell?

An enclosurel Boundary

l Interior regionlHereditary

store

2003/2004Cells: The Basic Units of Life4

Contributors to the Cell Theory:

§ Robert Hooke (named cells)

§ Anton Van Leeuwenhoek (saw microorganisms)

§ Robert Brown (discovered the nucleus)

§ Matthias Schleiden (plants are made of cells)

§ Theodor Schwann (animals are made of cells)

§ Rudolf Virchow (cells come from cells)

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2003/2004Cells: The Basic Units of Life5

Robert Hooke 1635~1703

In 1665The first person to

see and name cells.

He examined (dead) cork bark with a primitive microscope

Saw little cubicles which he called cells (cell = room, cubicle).

2003/2004Cells: The Basic Units of Life6

Anton van Leeuwenhoek(1632~1723)

Investigated the natural world using experimental methods supported by the evidence of the senses.

He made with his own hand certain most excellent lenses…

He invented the microscope……

2003/2004Cells: The Basic Units of Life7

And saw wondrouscreatures

Spirogyra…described by Leeuwenhoek

"Passing just lately over this lake, . . . and examining this water next day, I found floating therein divers earthy particles, and some green streaks, spirally wound serpent-wise, and orderly arranged, after the manner of the copper or tin worms, which distillers use to cool their liquors as they distil over. The whole circumference of each of these streaks was about the thickness of a hair of one's head. . . all consisted of very small green globules joined together: and there were very many small green globules as well."

2003/2004Cells: The Basic Units of Life8

Robert Brown

Robert Brown reported the existence of nucleus in 1831.

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2003/2004Cells: The Basic Units of Life9

Matthias Jacob Schleiden(solicitor & botanist 1804 ~ 1881).

Founder of the cell theory.Plants were aggregates of "fully

individualized, independent, separate being, namely the cells themselves."

Author of Basic Scientific Botany, the definitive textbook on botany at the middle of the 19th century.

Promoted commercial production of microscopes

2003/2004Cells: The Basic Units of Life10

Theodor Schwann(1810 - 1882).

Noticed nucleated units in animal tissue.

After discussions with Schleiden concluded that animals were composed of cells.

Did experiments that challenged Spontaneous Generation.

2003/2004Cells: The Basic Units of Life11

Rudolf Virchowpathologist (1858)

Omnis cellula e cellula" (where a cell arises, there a cell

must previously have existed).

First to state the cell theory:

"Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life."

2003/2004Cells: The Basic Units of Life12

The Cell Theory

w All living things are composed of cells and cell products.

w The cell is the smallest unit of life.w Living creatures come from the

growth and division of single cells.

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2003/2004Cells: The Basic Units of Life13

Cells Come in Different Shapes

2003/2004Cells: The Basic Units of Life14

Nostoc and Amoeba and Neurons

2003/2004Cells: The Basic Units of Life15

Diatom & Mouse Hair

2003/2004Cells: The Basic Units of Life16

Cells Come in Different Sizes

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2003/2004Cells: The Basic Units of Life17

Ostrich eggs are the biggest cells.

Most cells can only be seen with a microscope.

2003/2004Cells: The Basic Units of Life18

2003/2004Cells: The Basic Units of Life19

Microscopes:

Types of MicroscopesLight Microscope

Phase~Contrast MicroscopeScanning Electron

MicroscopeTransmission Electron

Microscope

2003/2004Cells: The Basic Units of Life20

Basic Cell Types

ProkaryoticSimple StructureSmallCell MembraneCytoplasmRibosomesNO ORGANELLES

Naked DNA

Eukaryotic Complex StructureSmall to LargeCell MembraneCytoplasm Ribosomes on membranesMembrane-Bound OrganellesNucleus contains DNA

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2003/2004Cells: The Basic Units of Life21

Prokaryotic Cells

Simple Structure: Membrane, Cytoplasm, Ribosomes, and Naked DNA

2003/2004Cells: The Basic Units of Life22

Prokaryotic Cells

Archeabacteria EubacteriaCyanobacteria

2003/2004Cells: The Basic Units of Life23

More Eubacteria

Lactobacillus Nitrosomas E. coli

2003/2004Cells: The Basic Units of Life24

A Basic Eukaryotic Cell

Note the complex

inner structure

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2003/2004Cells: The Basic Units of Life25

Eukaryotic Cell

AmoebaAmorphous shape & pseudopods

2003/2004Cells: The Basic Units of Life26

Sperm and Eggs

Small Motile Cells

Large Sessile Cells

2003/2004Cells: The Basic Units of Life27

Red Blood Cells

Small cells without a nucleus. Filled with hemoglobin for oxygen transport throughout the body

2003/2004Cells: The Basic Units of Life28

Plant and Animal Cells

Cell Membrane Cell Membrane &Cell Wall

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2003/2004Cells: The Basic Units of Life29

Cell Membrane

The fluid mosaic model: Phospholipids with embedded proteins.

2003/2004Cells: The Basic Units of Life30

Cytoplasm

Cell substanceFilled with solids,liquids,

organelles, cytoskeletal support fibers & inner network of membranes.

2003/2004Cells: The Basic Units of Life31

Nucleus

The Nucleus: Control Center of the Cell2003/2004Cells: The Basic Units of Life32

Mitochondria

Cell Powerhouse: Site of Cellular RespirationC6H12O6 + O2 ? CO2 + H2O

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2003/2004Cells: The Basic Units of Life33

Endoplasmic Reticulum

Rough & Smooth Endoplasmic Reticulum

Protein Synthesis Lipid Synthesis

2003/2004Cells: The Basic Units of Life34

Golgi Apparatus

A system of sacs and vesicles in the cytoplasm

2003/2004Cells: The Basic Units of Life35

Chloroplasts

Chloroplasts : Site of PhotosynthesisCO2 + H2O ? C6H12O6 + O2

2003/2004Cells: The Basic Units of Life36

Central Vacuole

Characteristic of a Plant Cell

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2003/2004Cells: The Basic Units of Life37

Cytoskeleton

Rat Smooth Muscle Cells: Actin & Myosin

2003/2004Cells: The Basic Units of Life38

Flagella & Cilia

Trypanosome

Trypanosome Euglena Tracheal Cells

2003/2004Cells: The Basic Units of Life39

Sources

¢ http://www.ucmp.berkeley.edu/history/leeuwenhoek.html

¢ http://www.clovis.cc.nm.us/ms/adkinsj/biol113/Lectures/history_of_biology.htm

¢ http://buglady.clc.uc.edu/biology/bio104/hist_sci.htm

¢ http://www.avonmaitland.on.ca/GDCI/mains/stu-proj/science/1996/3a/cells/enrich/ryan/index.htm

2003/2004Cells: The Basic Units of Life40

§ http://members.aol.com/Poobah78/biology.html

§ http://www.nih.gov/nigms/news/science_ed/whatcell.html

§ http://biology.lsa.umich.edu/~www/bio100/lec4/index.htm§ http://www.umanitoba.ca/faculties/medicine/units/history/lesion/lesion10

.html

§ http://www.nceas.ucsb.edu/~alroy/lefa/Virchow.html

§ http://ostracon.biologie.uni-kl.de/b_online/e01/schleide.htm§ http://wwwihm.nlm.nih.gov/

§ http://www.biology.arizona.edu/cell_bio/tutorials/pev/main.html