1 ZeoSys GmbH

The CONTRAfluranTM-System

A product of ZeoSys GmbH

Produced by Pneumatik Berlin GmbH PTM

Research- and Distribution-Company for Antipollution-, Medical- and Energy Technology

Acknowledged Technology-Company for Medical Technology, certified according to MDD

2 ZeoSys GmbH

Operational Principle

1. Adsorption of volatile anaesthetics on solid micro-porous

Loaded Adsorbens

2. Desorption of the anaesthetics out of the aleardy loaded adsorbents

Desorbate

3. Treatment / fine cleaning of the desorbate

Final Product (volatile anaesthetics with the

required chemical and biological puritiy specification)

4. Regeneration of the used adsorbens

Target

I Removal of the volatile anaesthetic gases out of the clinic and hospital rooms

II Recovering of the volatile anaesthetics

Operatopmal principle of the system

Treatment of the

desorbate

Filter Production Center

Adsorption During Operation

Hospitals, Clinics

and Industries Desorption

Equipment

3 ZeoSys GmbH

3 ZeoSys GmbH

16 different solid state adsorbents with different compostion, particle

and pore size as well as geometry have been investigated. Based on

the following parameter, it was possible to select the optimum ones:

- Adsorption capacity

- Breakthrough curve,

- Flow resistance

- desorption ability

- Regeneration

Selection of solid state adsorbents

4 ZeoSys GmbH

CONTRAfluranTM-System

CONTRAfluranTM

Anaesthetic Gas Filter Mount Logistics

Components of the

CONTRAfluranTM-Systems

5 ZeoSys GmbH

The CONTRAfluranTM-Filter

The CONTRAfluranTM-Filter consists

of solid materials, distinguished by

their rugged grain structure, extensive

surface area and high micro-porosity.

This highly porous internal structure

adsorbs efficiently and retains

anaesthetic gas components

selectively from the exhaled gas as it

passes through the filter.

6 ZeoSys GmbH

The Mount

Standard-Mount

The Standard-Mount is a safe alternative for the

device-near attachment of the filter.

7 ZeoSys GmbH

SENSOfluranTM

SENSOfluranTM is a mount with integrated Fill

Level Control Unit.

SENSOfluranTM

gives signals

for the punctual

filter change.

The Mount

8 ZeoSys GmbH

The Logistics

ZeoSys GmbH

Distributors

CUSTOMER CUSTOMER

ZeoSys GmbH

Distributors

CONTRAfluranTM-Filter order

Immediate confirmation of order

and punctual delivery

Information on the collection of

filled filters

Punctual collection and credit

1

2

3

4

9 ZeoSys GmbH

Application areas of the

CONTRAfluranTM-System

CONTRAfluranTM-Filter

Application in

ORs with

exhaust device

Application in

ambulatory

treatment areas

Application with

the AnaConDa®

System

10 ZeoSys GmbH

Application in ORs with

exhaust device

The CONTRAfluranTM-Filter is to be attached to the outlet of the

anaesthesia machine by means of a ISO 22 flexible hose.

11 ZeoSys GmbH

Application in ambulatory treatment areas

The CONTRAfluranTM-Filter is to be attached to the outlet of the respirator

by means of a ISO 22 flexible hose.

12 ZeoSys GmbH

Application with the AnaConDa®-System

The CONTRAfluranTM-Filter is to be attached to the outlet of the respirator by

means of a ISO 22 flexible hose.

For the assembly of the hose to the outlet of the respirator a straight connector

22mm (a/i) with 6mm connection is to be used.

The filter is to be attached to the gas monitor by means of a 6mm hose.

13 ZeoSys GmbH

The CONTRAfluranTM-Filter

during practical use

14 ZeoSys GmbH

Advantages of the

CONTRAfluranTM-System

• Inhalation of anaesthetic gases and sedation of patients can be done---------------

- everywhere

In ORs, Intensive Care Units, as well as mobile and ambulatory treatment areas,

independent of the anaesthetic gas suction device.

• Safety of patients and personnel

The filter adsorbs the anaesthetic gases Sevofluran, Isofluran or Desfluran efficiently

out of the exhaled air of a patient.

• Maximum adsorption capacity and low flow-resistance

Adsorption capacity of approx. 300 ml (400 g) anaesthetics

Depending on the way of application the filter is continuably usable up to 5 days.

Low flow-resistance value of 1.5 mmWs, so that no further vacuum devices

are necessary.

• High economic efficiency

Favorable cost/performance ratio. Pledge system and cost-free disposal.

• Protection of the environment

CFC and HCFC pollute the atmosphere and play a significant role to the global

warming and ozon depletion.

15 ZeoSys GmbH

According to the estimations made, at present only in Germany about more

than 100000 liters of volatile anesthetics like Desfluran, Sevofluran and

Isofluran are used. Worldwide consumption of anaesthetics is estimated to be

more than 4500 tons.

● approx. 95% of it escapes into the ambient air and free atmospher.

The global Warming potential (GWP) of the volatile anaesthetics is upto 2000

times higher than that of CO2.

Global Warming Potentials (GWP) comparison:

Isoflurane : 1,100 x CO2

Sevoflurane: 1,600 x CO2

Desflurane: 1,900 x CO2

Volatile anaesthetics are mostly fluorinated

or chlorinated hydrocarbons. Thus, they are

harmful to patients and personnel

These groups of compounds possess ozone

depletion potential as well as they contribute

to global warming (greenhouse effect).

The Environmental aspect

16 ZeoSys GmbH

References

1 Universitätsklinikum Halle Wittenberg

2 Universitätsklinikum Münster

3 Ubbo-Emmius Klinik Aurich

4 Medizinische Hochschule Hannover

5 Carl-Thiem-Klinikum Cottbus

6 Klinikum Schwäbisch-Gmünd / Stauferklinik Mutlangen

7 Städtisches Klinikum Sindelfingen

8 Georgius-Agricola Klinikum Zeitz

9 Klinikum St. Marien Amberg

10 Klinikum Ludwigshafen

11 Universitätsklinikum Aachen

12 Westpfalz-Klinikum Kaiserslautern

13 HELIOS-Klinikum Berlin-Buch

14 Universitätsklinikum Mannheim

15 St.-Vincentius-Krankenhaus Speyer

16 Anästhesiepraxis Holger Kühn Bochum

17 Krankenhaus Düren

18 Kreiskrankenhaus Emmendingen

19 Klinikum Niederlausitz GmbH

20 Marienhospital Oelde

21 Deutsches Herzzentrum Berlin

22 Clara-Wolff-Haus am Krankenhaus St. Joseph-Stift, Dresden

23 Universitätsklinikum Erlangen

24 Klinikum Nürnberg-Nord

25 HELIOS Klinikum Bad-Saarow

26 Klinikum Südstadt Rostock

27 Evangelisches Krankenhaus Hamm

28 Universitätsklinikum Schleswig-Holstein / Campus Lübeck

29 Universitätsklinikum Hamburg-Eppendorf

30 Johanniter-Krankenhaus Genthin-Stendal

17 ZeoSys GmbH

Summary

The CONTRAfluranTM-Filter:

• combines the advantages of multi-adsorbents that can perform -------------

-complementary

• can be attached easily to every equipment rail by using the mount

• is recommended by the manufacturers of different-anaesthetic devices

• is equipped with Fill Level Control Unit (SENSOfluranTM)

• is classified as a medicine product of Class I according to Medical Device

Directive (MDD)

• is produced in an enterprise that is certified according to MDD

• is applied in more than 200 hospitals all over Germany, Switzerland,

Austria, Finnland, Spain and Holland

18 ZeoSys GmbH

Contact Information

RTD Company for Environment-, Medical- and Energy Technology

Falkenberger Straße 40

D - 13088 Berlin

Research and Development Department:

Mrs. Dr. Laß-Seyoum: Tel.: +49 30 - 92 70 10 58 Mail: lass-seyoum@zeosys.de

Mr. Friedrich: Tel.: +49 30 - 92 70 10 59 Mail: friedrich@zeosys.de

Sales and Marketing Department:

Ms. Stubenvoll: Tel.: +49 30 - 92 70 10 44 Mail: stubenvoll@zeosys.de