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The Division of Research & Scholarship

Activity Report

1st Quarter, Fiscal Year 2018

Oct 1 - Dec 31, 2017

FY18 Q1 Department of Research & Scholarship Activity Report 1

I - Office of Human Research Protection 1st Quarter, Fiscal Year 2018

Total Number of IRB Protocols Active during Quarter: 1,084

Total Number Includes New Protocols Approved during Quarter: 222

IRB-A Categories: Cardiology, Vascular

Surgery, Plastic Surgery, General Surgery,

Orthopedics, Rehabilitation, Neurology, Nursing,

Women’s, Internal Medicine, Pharmacy,

Infectious Diseases, General (non-

pediatrics/non-oncology)

IRB-B Categories: Pediatrics (all),

Women’s, Cardiology, Orthopedics, Internal

Medicine, Infectious Diseases, Neurology,

General (non-adult oncology)

IRB-C Category: Adult Oncology

*N/A/ Other: Chart reviews, questionnaires, pilot

studies, feasibility studies, biology, Humanitarian

Device Exempt (HDE) and Humanitarian Use

Device (HUD) studies, specimen storage,

comparative effectiveness research,

social/behavioral research, curriculum

development, etc.

STUDY PHASES

Phase I 54 4.98%

Phase II 111 10.24%

Phase III 187 17.25%

Phase IV 9 0.83%

N/A/Other* 723 66.70%

Total 1084 100.0%

REVIEWING COMMITTEE

A 406 37.45%

B 215 19.83%

C 286 26.38%

Western IRB (External) 50 4.61%

NCI CIRB (External) 127 11.72%

Total 1084 100%


FUNDING SOURCE REVIEW TYPE

Federally

Funded

283 Full Board 318

Industry

Sponsored

182 Expedited

Review

444

Private Non-

Profit

38 Facilitated

Review (USO)

43

Internal Funding 45 Exempt 50

No Funding 488 NCI CIRB 127

Other 48 Western IRB 50

Not Human

Subjects

Research

52

Total 1084 Total 1084

Clinical Research: any research or procedure involving human subjects in vivo or the use of human samples for the development and evaluation of patient therapies such as diagnostic tests, drug therapies, or medical devices. It includes early clinical studies, epidemiological studies and clinical trials. It does not include a Faculty Member’s participation in the design of a clinical study for which he/she is subsequently neither a participant nor an author.


II - GHS Clinical Trials Report 1st Quarter, Fiscal Year 2018

1 Clinical Trial: For the purpose of this report, a clinical trial is defined as a prospective, biomedical or behavioral research study of human subjects that is designed to answer specific questions about biomedical or behavioral interventions (drugs, biologics, treatments, devices, or new ways of using known drugs, biologics, treatments, or devices). This definition incorporates the major points of the term as defined by the NIH, DHHS, ICMJE, ICH GCP E6, FDA, WHO and the clinicaltrials.gov website. 2 Other types of clinical trials include prevention, treatment, vitamin, symptom management and radiation.

Drug Device Other TOTAL

Internal Medicine Cardiology 3 8 1 12

ID / GI and Liver Center 6 0 0 6

Endoc 2 0 2 4

Oncology 252 2 44 298

CIOS 0 1 0 1

NeuroSciences 2 1 0 2

GHS Orthopedics 0 3 0 3

Hawkins Foundation 2 1 3 6

Sub-Total 267 16 50 332

Pediatrics GHS Pediatrics 10 0 2 12

Hem/Onc 36 0 0 36

Sub-Total 46 0 2 48

Surgery 3 20 4 27

Womens 5 4 2 11

TOTAL 321 40 58 418

Active Interventional Clinical Trials 1

Study Type

3% 1% 1%

71%

0%

1%

1%

1%

3%

9%

6%

3%

Interventional Clinical Trials by Department

Cardiology

ID / GI and LiverCenter

Endoc

Oncology

CIOS

NeuroSciences

GHS Orthopedics

77%

9%

14%

Interventional Clinical Trials by Study Type

Drug

Device

Other


3 Other types of funding include foundation and departmental.

Phase I Phase II Phase III Phase IV IndustryFederal

FundingOther

Internal Medicine

Cardiology 0 0 1 1 9 2 1

ID / GI and Liver Center 0 1 5 0 5 1 0

Endoc 0 0 1 1 3 1 0

Oncology 18 95 133 2 91 193 6

CIOS 0 0 0 0 0 0 1

NeuroSciences 0 0 2 0 3 0 0

GHS orthopedics 0 0 1 0 1 1 1

Hawkins Foundation 0 0 1 2 3 0 4

Sub-Total 18 96 144 6 115 198 13

Pediatrics Regular 0 0 8 1 9 2 1

Hem/Onc 0 9 26 0 1 35 0

Sub-Total 0 9 34 1 10 37 1

Surgery 0 0 5 0 21 2 3

Womens 0 0 3 0 7 4 1

TOTAL 18 105 186 7 153 241 18

Active Interventional Clinical Trials per Phase and Funding Source

Phases Funding Source

6%

33%

59%

2%

Interventional Clinical Trials by Phase

Phase I

Phase II

Phase III

Phase IV

37%

59%

4%

Interventional Clinical Trials by Funding Source

Industry

FederalFunding

Other


286

3352

297

3757

321

4058

Drug Device Other

Interventional Clinical Trials per Study type

QR1FY2016 QR1FY2017 QR1FY2018

43

96

165

16

97

173

518

105

186

7

Phase I Phase II Phase III Phase IV

Interventional Clinical Trials per Phase


131

233

7

146

234

12

153

241

18

1 2 3

Interventional Clinical Trials per Funding Source


October November December

Internal Medicine Cardiology 0 1 1

ID / GI and Liver Center NR NR NR

Endoc 4 4 4

Cancer Institute 25 29 53

CIOS 14 21 23

ITOR 4 5 5

Sub-Total 19 15 13

Neurosciences 28 0 2

GHS orthopedics 1 0 0

Hawkins Foundation 11 7 6

Sub-Total 10 8 2

Pediatrics Regular 0 0 0

Hem/Onc 1 0 NR

Sub-Total 3 2 0

Surgery 13 14 4

Womens 63 65 46

TOTAL 108 104 65


Enrollment Number


NA: not Available.

October November December

Internal Medicine Cardiology 0 1 1

ID / GI and Liver Center NA NA NA

Endoc 4 4 4

Cancer Institute 25 29 53

CIOS 14 21 23

ITOR 4 5 5

Sub-Total 19 15 13

Neurosciences 28 0 2

GHS orthopedics 1 0 0

Hawkins Foundation 11 7 6

Sub-Total 10 8 2

Pediatrics Regular 0 0 0

Hem/Onc 1 0 NA

Sub-Total 3 2 0

Surgery 13 14 4

Womens 63 65 46

TOTAL 108 104 65


Enrollment Number


III - Sponsored Programs Activity 1st Quarter, Fiscal Year 2018

OVERALL SUMMARY

EXPENDITURE SUMMARY

FY 18 Expenditures

Q1 $ 1,639,657

FY17 Q1 FY18 Q1 % Change

Value of Proposals 7,632,679$ 4,085,081$ -46%

Number of Proposals 20 24 20%

Value of Awards 1,612,265$ 3,827,128$ 137%

Number of Awards 17 24 41%

Quarterly Summary & Comparison


PROPOSAL SUMMARY

PR

IME

SU

B

TO

TA

L

Direct Cost Indirect Cost Cost Share Total Requested

Obstetrics and Gynecology 2 2 4 666,147$ 30,783$ 949,349$ 696,930$

Surgery (General) 1 1 14,799$ 14,799$

Family Medicine 3 3 59,045$ 905$ 59,950$

Surgery (Orthopaedics) 1 1 78,174$ 44,090$ 122,264$

Internal Medicine 1 2 3 132,312$ 68,511$ 200,823$

Pediatrics 1 1 2 24,000$ 10,716$ 34,716$

Psychiatry/Behavioral Medicine

Pathology

Radiology

Anesthesiology

Emergency Medicine 2 2 14,504$ 8,180$ 22,684$

Roger C. Peace 1 1 18,912$ 18,912$

Cancer Institute 1 1 2 899,432$ 275,331$ 1,174,763$

Clinical Integration 3 3 1,376,556$ 645,516$ 1,376,556$

Emergency Management 1 1 12,684$ 12,684$

Health Sciences Center 1 1 350,000$ 350,000$

TOTAL 16 8 24 3,646,565$ 438,516$ 1,594,865$ 4,085,081$

Total Proposal Activity


AWARD SUMMARY

NE

W

CO

NT

INU

ED

TO

TA

L Direct Cost Indirect

CostCost Share Total Awarded

Obstetrics and Gynecology 1 1 2 603,755$ 603,755$

Surgery (General) 1 1 20,000$ 20,000$

Family Medicine

Surgery (Orthopaedics) 1 1 12,624$ 7,120$ 19,744$

Internal Medicine 2 2 4 1,339,793$ 44,369$ 505,784$ 1,384,162$

Pediatrics 3 2 5 207,083$ 31,513$ 238,596$

Psychiatry/Behavioral Medicine

Pathology

Radiology

Anesthesiology

Emergency Medicine 2 2 474,550$ 3,637$ 478,187$

Roger C. Peace 2 2 75,130$ 3,691$ 78,821$

Cancer Institute 1 1 2,800$ 2,800$

Clinical Integration 1 2 3 885,000$ 379,834$ 885,000$

Bradshaw Institute 1 1 2 60,239$ 5,824$ 66,063$

Health Sciences Center 1 1 45,818$ 4,182$ 50,000$

TOTAL 12 12 24 3,726,792$ 100,336$ 885,618$ 3,827,128$

Total Award Activity


DIABETES ACTIVITY SUMMARY

The Office of Sponsored Programs will report diabetes related activity in fiscal year 2018 as this is a performance goal for the system. Projects focused on diabetes include those that relate to diabetes or pre-diabetes, including incidence, disease process, treatment, and outcomes. Associated projects address diseases and health outcomes that are closely related with diabetes or pre-diabetes.

Number Value Number Value

Q1 2 259,803$ 3 1,402,485$

Number Value Number Value

Q1 3 599,375$ 1 750,000$

Included projects noted by project title.

* Focused refers to direct disease treatment or prevention.

**Associated refers to projects whose main focus is not diabetes,

but whose outcome may ultimately impact diabetes prevention/care.

Associated**

Diabetes Related Projects

Proposals

Focused* Associated**

Awards

Focused*


Greenville Health System – Extramural Proposals

Fiscal Year 2018 – Quarter 1 The Office of Sponsored Programs reports that GHS faculty and staff members submitted the following 24 proposals, totaling $4,085,081, during the first quarter of fiscal year 2018. Department of Obstetrics and Gynecology

Elena Huston Nurse-Family Partnership National Service Office Nurse-Family Partnership - Laurens County Expansion This grant will fund the addition of three new Nurse Home Visitors to serve Laurens County. Project Dates: 01/01/2018 - 12/31/2020 Total/Direct Cost: $474,675; Cost Share: $949,349 Dr. Amy Crockett March of Dimes Supporting South Carolina OB Providers to Reduce Preterm Births through CenteringPregnancy Group Prenatal Care** This project will support the obstetric providers who are implementing CenteringPregnancy group prenatal care throughout SC by providing training, technical assistance, and materials. It will continue to provide data analysis of the birth outcomes resulting from CenteringPregnancy. Project Dates: 02/01/2018 - 12/31/2018 Total: $25,929; Direct Cost: $23,572; Indirect Cost: $2,357 Dr. Kacey Eichelberger National Institutes of Health (NIIH) via University of North Carolina Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD)* This is a multi-site randomized clinical trial in which the use of insulin + placebo vs. insulin + metformin will be evaluated in pregnant women with a diagnosis of overt type 2 diabetes mellitus. It will assess whether pharmacological treatment of overt type 2 diabetes mellitus during pregnancy with insulin + metformin improves neonatal outcome or maternal morbidities. Project Dates: 01/01/2018 - 06/30/2021 Total: $78,826; Direct Cost: $50,400; Indirect Cost: $28,426 Dr. Jeffrey Elder Rivkin Center for Ovarian Cancer via USC Educational Foundation Immunologic and Inflammatory Markers of Endometriosis Associated Ovarian Cancers This project will explore whether the genetic characteristics of endometriosis that allow its unrestricted growth, when combined with the local inflammation that the endometriosis creates, cause some women with this disease to develop cancer. Project Dates: 01/01/2018 - 12/31/2019 Total/Direct Cost: $117,500 Department of General Surgery

Mike Walls Firehouse Subs Public Safety Foundation Public Access Bleeding Control Stations The grant requested support to purchase public access bleeding control stations, which would assist in the event of a mass casualty incident or an incident involving severe bleeding. Project Dates: 03/01/2018 - 05/31/2018 Total/Direct Cost: $14,799


Department of Internal Medicine

Dr. Anjani Jammula Pfizer via University of South Carolina Integrating a Personalized Patient-Specific Priority Tool to Enhance Shared Decision Making for Patients with Inflammatory Bowel Disease GHS will serve as the clinical research partner by allowing the project to be conducted in the GI Clinic. GHS will provide feedback on how to make the survey tool fit within the flow of clinical care provided for IBD patients and how the priority graphic can be designed to be most useful for providers. Project Dates: 01/01/2018 - 12/31/2019 Total: $14,846; Direct Cost: $11,598; Indirect Cost: $3,248 Dr. Meenu Jindal American Cancer Society Decision Aid Implementation for Colorectal Cancer Screening in Primary Care Settings This project is aimed at increasing opportunity for discussion between primary care physicians and patients regarding colorectal cancer screening. Decision aid will be used to help initiate discussion regarding screening intervention. This project will also involve education of internal medicine residents in shared decision making and use of decision aid. Project Dates: 01/01/2018 - 12/31/2018 Total/Direct Cost: $5,000 Michelle Stancil Department of Defense via Clemson University STOP T2DM: Redesigning the DoD's Mobile Health Care Environment for prediabetic patients seeking to prevent incurring type-2 diabetes* GHS will provide clinical insight to advance the MHEC technology to support individuals with prediabetes make behavior modifications to prevent development of type 2 diabetes or delay onset on type 2 diabetes. GHS will aid in the conduction of formal user-centered design research activities of the new MHCE prediabetes technology to ensure the new design/product meets the needs and challenges of individuals living with prediabetes. Project Dates: 08/01/2018 - 07/31/2020 Total: $180,977; Direct Cost: $115,714; Indirect Cost: $65,263 Department of Emergency Medicine

Dr. Ron Pirrallo NASA via Clemson University Enhancing the Meaningfulness of Work for Astronauts through Targeted Experiment Involvement and Feedback GHS will facilitate interviews with 20 emergency medicine physicians regarding the role of patient feedback in enhancing the meaningfulness of their work, participate in the construction of the interview schedule, and help analyze interview responses. Project Dates: 10/01/2018 - 09/30/2019 Total: $16,350; Direct Cost: $10,454; Indirect Cost: $5,896 Dr. Stephanie Bailey NASA via Clemson University Validating Physiological and Neurological Measures of Teamwork The goal of this project is to produce guidelines on prospective neurological and physiological metrics for functional and dysfunctional aspects of teamwork, namely affective, attitudinal, and motivational aspects that can be captured with physiological indicators. Project Dates: 10/01/2018 - 09/30/2019 Total: $6,334; Direct Cost: $4,050; Indirect Cost: $2,284


Cancer Institute

Dr. John O’Connell Department of Defense Sequencing of targeted kinetic nanotherapies with decoupling of deiodinase regulated thyroid hormone signaling to extinguish breast cancer metastases The objectives of this study are to determine if the following are possible and to what extent: 1) radiation and electricity can be delivered to cultures of breast cancer cells in a sequenced fashion that completely extinguishes the breast cancer cells; 2) depriving cancer cells of access to an increased supply of energy at the time of severe damage caused by electricity, radiation or their combination can lead to fewer surviving cancer cells with minimal harm to normal tissues. Project Dates: 10/01/2018 - 09/30/2020 Total: $545,446; Direct Cost: $375,000; Indirect Cost: $170,446 Dr. Mark O’Rourke American Cancer Society via MUSC A Multi-Component Program to Enhance Equity in Advanced Cancer Care This study will test the effectiveness of the Serious Illness Care Program in improving access to high-quality communication for African-American cancer patients and evaluate the program’s impact on patient and systems-level outcomes while monitoring program delivery. Project Dates: 07/01/2018 - 06/30/2023 Total: $629,317; Direct Cost: $524,432; Indirect Cost: $104,885 Department of Pediatrics

Dr. Jonathan Markowitz National Institutes of Health (NIH) via University of North Carolina Tooth matrix biomarkers to identify early life environmental risk factors for eosinophilic esophagitis This study aims to collect and analyze teeth from children with EoE and controls. GHS will be responsible for identifying subjects and healthy controls appropriate for inclusion in the study and ensuring that study procedures are followed for the collection of study material. Project Dates: 07/01/2018 - 06/30/2020 Total: $29,716; Direct Cost: $19,000; Indirect Cost: $10,716 Dr. Desmond Kelly South Carolina Developmental Disabilities Council 2018 Nurturing Developing Minds Conference This conference provides education and support for professionals who work directly with people with developmental disabilities and their families. National and regional experts share information on interventions and tools that attendees can apply directly in their work to improve the quality of life of the individuals with disabilities and their families. Project Dates: 02/01/2018 - 02/28/2018 Total/Direct Cost: $5,000 Roger C. Peace Rehabilitation Hospital

Dr. Kevin Kopera South Carolina Spinal Cord Injury Research Fund Prospective Study Registry of Individuals in South Carolina with Spinal Cord Injuries The purpose of this project is to continue development of and enrollment in a prospective Registry Database of patients with SCI. Demographic and Injury Related Common Data Elements are being collected from spinal cord injury (SCI) patients and their clinicians from Roger C. Peace Rehabilitation Hospital. Project Dates: 12/01/2017 -11/30/2018


Total/Direct Cost: $18,912 Department of Family Medicine

Dr. Irfan Asif South Carolina Department of Health and Human Services The Future of Family Medicine Education: The Clinic, the Curriculum, and the Community The purpose of this grant is to seek funding to develop curricula that breaks traditional barriers to customary family medicine training in a rural environment and focuses on better patient access, improved quality of care, cost-efficiency, and reduced provider burnout. Project Dates: 01/01/2018 - 12/31/2018 Total/Direct Cost: $50,000 Dr. Vicki Nelson American Medical Society for Sports Medicine Foundation Bullying and Hazing in Collegiate Student Athletes: Owning Responsibility and Building a Culture of Safety The proposed study will establish a foundation of research defining the impact and extent of hazing among collegiate athletes and disseminate tools with the potential to immediately impact the safety and wellbeing of collegiate athletes by reducing hazing and bullying in the athletic community. Project Dates: 02/01/2018 - 01/31/2019 Total: $5,000; Direct Cost: $4,545; Indirect Cost: $455 Dr. Vicki Nelson American Medical Society for Sports Medicine Foundation Defining the Effects of Concussion on Driving Safety in Athletes The proposed study will establish a foundation of research defining the impact of concussion on driving safety and performance among high school and college athletes. Project Dates: 02/01/2018 - 01/31/2019 Total: $4,950; Direct Cost: $4,500; Indirect Cost: $450 Department of Orthopaedic Surgery

Dr. Brayton Shirley Smith & Nephew Steadman Hawkins Clinic of the Carolinas Fellowship Program This will be a one-year fellowship for a US Residency Graduate with the aim of providing a strong academic and clinical foundation with high volume exposure to primary and revision total hip and knee replacements. Project Dates: 08/01/2018 - 07/31/2019 Total: $122,264; Direct Cost: $78,174; Indirect Cost: $44,090 Department of Emergency Management and Preparedness

Kristen Kolleda Firehouse Subs Public Safety Foundation Medsled Emergency Evacuation Equipment This request seeks support for enhancement of current life safety equipment to be used during a fire or other evacuation emergency at Patewood Memorial Hospital. Medsled evacuation equipment, including specialty pediatrics equipment, is vital for hospital staff to be able to use during a fire and will correlate to increased positive health outcomes in the event of a disaster. Project Dates: 03/01/2018 - 05/31/2018 Total/Direct Cost: $12,684


Health Sciences Center

Dr. Brenda Thames BlueCross BlueShield of South Carolina Foundation MedEx - Claflin University Pipeline Pilot Project This project will form a consortium of academic and clinical institutions focused on increasing the pool of underrepresented minority students prepared to enter medical school. Project Dates: 01/01/2018 - 12/31/2020 Total/Direct Cost: $350,000 Clinical Integration

Anne Marie Maertens The Duke Endowment AccessHealth Greenville/Laurens (AHGL)** AHGL is a collaborative community program within Greenville that works with GHS, Bon Secours St. Francis Health System, and community safety-net partners to provide healthcare transitions and improve access through medical home placement. Project Dates: 06/01/2018 - 05/31/2021 Total/Direct Cost: $750,000; Cost Share: $489,093 Candice Hipp The Duke Endowment Accountable Communities / Health Extension Project** GHS and Clemson University Cooperative Extension Service seek to continue and expand the Health Extension program in Greenville County while applying lessons learned from the initial pilot. Health Extension will target efforts and evaluation on Hypertension self-management and continue to serve the underserved populations with Hypertension education and resources. Project Dates: 06/01/2018 - 05/31/2020 Total/Direct Cost: $626,556; Cost Share: $156,423 Heather Goss South Carolina Office of Rural Health Healthy Oconee The most recent Community Health Needs Assessment concluded that there is an opportunity for improvement around healthy eating, active living and food security in Oconee County. The Healthy Oconee coalition will investigate these opportunities, identify health disparities and barriers to health in our community, and work collaboratively to bridge gaps and address needs. Project Dates: To be determined Total: To be determined


Greenville Health System – Awards Fiscal Year 2018 – Quarter 1

The Office of Sponsored Programs reports that GHS faculty and staff members received the following 24 awards, totaling $3,827,128, during the first quarter of fiscal year 2018. Bradshaw Institute for Community Child Health & Advocacy

Jane Witowski Connecticut Children’s Medical Center Applying Technological Innovations to Support Family Engagement in Developmental Promotion, Early Detection, and Referral and Linkage to Community Resources GHS, through its Help Me Grow Program, will participate in this pilot project to implement the Well Visit Planner within the care coordination process and share experience, strategies, and successes with peers to evaluate the use of this tool intended to improve well-child care by collecting information and concerns from parents prior to pediatric care visits. Project Dates: 06/01/2017 - 03/31/2018 Total/Direct Cost: $2,000 Jane Witowski CDC via SC Department of Health and Environmental Control Help Me Grow Through the Help Me Grow program, Greenville Health System will facilitate education state-wide about Zika virus prevention, treatment, and follow-up. Project Dates: 03/23/2017 - 07/31/2018 Total Awarded: $64,063; Direct Cost: $58,239; Indirect Cost: $5,824 Department of Orthopaedics

Stephanie Tanner NSF via Cornell University via Clemson University SCH EXP: Home +, An Intelligent and Interoperable Suite of Robotic Furnishings, Learning and Evolving with Their Users This project will improve the health and quality of life for the 14,378+ persons with ADRD and their caregivers who live in Greenville, Anderson, Pickens and Oconee counties. Through the addition of a new location in Oconee County, GHS will be able to provide more accessible and increased diagnostic, healthcare and community services to these underserved populations. Project Dates: 10/01/2017 - 09/30/2018 Total Awarded: $19,744; Direct Cost: $12,624; Indirect Cost: $7,120 Health Sciences Center

Dr. Peggy Wagner Patient-Centered Outcomes Research Institute (PCORI) Engaging Patients in Diabetes-Focused Research to Improve Access, Self-Management, and Service Delivery* This project will engage patients reflective of the income and racial diversity differences of Laurens and Greenville Counties. This will clarify county context-specific areas of interest for diabetes-focused research. Establishing partnerships and enhancing research capacity in the vastly different rural/urban contexts will contribute to diabetes research essential to mitigating disparities in access, service delivery, and self-management of the chronic disease. Project Dates: 10/01/2017 - 09/30/2018 Total Awarded: $50,000; Direct Cost: $45,818; Indirect Cost: $4,182


Roger C. Peace Rehabilitation Hospital

Dr. Kevin Kopera South Carolina Spinal Cord Injury Research Fund via USC Community-based Virtual Reality Group Exercise Training in Persons with Spinal Cord Injury The overarching goal of this study is to determine whether differences exist in the cardio-metabolic health, psychosocial health, and QOL in persons with SCI who lead active lifestyles vs. those who are sedentary, as well as to determine whether training can improve such and if the effect of training are maintained 3 months post-intervention. Project Dates: 12/31/2016 - 11/30/2017 Total/Direct Cost: $5,000 Dr. Kevin Kopera Department of Veterans Affairs Adaptive Sports Programs for Disabled Veterans and Disabled Members of the Armed Forces GHS/RCP Adaptive Sports Outreach This year's funding will support the GHS Adaptive Sports program which intends to encourage and enable disabled veterans and service members (participants) to participate in sports and learn how they can resume activities they enjoy or learn new activities by using adaptive sports equipment. The program provides a multi-tiered approach to adaptive sports that addresses the veterans’ current abilities and helps to build physical and mental strength. Project Dates: 09/01/2017 - 09/30/2018 Total Awarded: $73,821; Direct Cost: $70,130; Indirect Cost: $3,691 Department of Obstetrics and Gynecology

Dr. Amy Crockett NorthShore University HealthSystem PINC Cradle This project intends to collect maternal serum, placentas, and umbilical cord blood from women participating in both group prenatal and individual prenatal care, for analysis of the expression of stress-related genes, hormones, cytokines and other markers of systemic inflammation. Analyses aim to identify differences in inflammatory profiles and examine whether these profiles may predict or explain the risk for adverse birth outcomes. Project Dates: 03/20/2017 - 03/19/2018 Total/Direct Cost: $46,155 Elena Huston HHS via Children's Trust of South Carolina Nurse Family Partnership NFP provides specially trained nurses that regularly visit young, first-time moms-to-be, starting early in the pregnancy, and continue through the child’s second birthday. NFP empowers first-time moms to transform their lives and create better futures for themselves and their babies. Project Dates: 10/01/2017 - 09/30/2018 Total/Direct Cost: $557,600 Department of Surgery

Debra Kitchens SC Department of Health and Environmental Control Emergency Medical Services for Children: Trauma Symposium Funding to support hosting a symposium where pediatric care experts will provide expertise, which focuses on the special treatment needs of critically ill or injured pediatric patients. Project Dates: 10/17/2017 - 02/28/2018 Total/Direct Cost: $20,000


Department of Pediatrics

Dr. Bryce Nelson CDC via The University of North Carolina at Chapel Hill SEARCH for Diabetes in Youth Registry Study, Phase 4: Carolina Center (Component A)* Funding to support this year's activities. SEARCH for Diabetes in Youth is a national multi-center study aimed at understanding more about diabetes among children and young adults in the United States. SEARCH has been helping to find answers about the types of diabetes, its complications, and how having diabetes affects the lives of children and young adults. Project Dates: 09/30/2017 - 09/29/2018 Total Awarded: $61,304; Direct Cost: $39,197; Indirect Cost: $22,107 Dr. Nicholas Kelley Spartanburg County Foundation Directed Care Greenville Health System (GHS) Children's Hospital will provide on-site care to high-risk pediatric patient in Spartanburg County. Clinical exam rooms will be developed and operate at Hope Center for Children and Project Hope. These will provide easy access to high-quality medical services for foster care and autistic patients. As populations with high medical and mental health needs, we will expand their access to care with the goal of improving medical outcomes and meeting mental health needs. Project Dates: 11/01/2017 - 10/31/2018 Total/Direct Cost: $15,000 Dr. Anne Kinsman Health Resources and Services Administration (HRSA) via MUSC Leadership Education in Neurodevelopmental and Related Disorders Training Program (SC LEND) The LEND training program works to improve access to healthcare and services for children with disabilities and their families by training diverse professionals in leadership, cultural competence, clinical knowledge, advocacy, and collaboration between health care professionals and families. Project Dates: 07/01/2017 - 06/30/2018 Total Awarded: $132,292; Direct Cost: $122,886; Indirect Cost: $9,406 Emily Durham Dabo's All In Team® Foundation Canine FETCH Program The Canine FETCH Unit is a facility dog program at the GHS Children’s Hospital that provides patients and families with animal assisted therapy to improve physical, social, emotional, and cognitive functioning of patients by using an animal in goal directed interventions based on patients’ needs. Project Dates: 11/01/2017 - 10/31/2018 Total/Direct Cost: $10,000 Dr. Cary Stroud Charity Ball Board of Greenville Overnight and Day Camps for Medically Fragile Children This funding will support medically supervised overnight and day camps for medically fragile children and their families, in order to give them an opportunity to participate in a community and activities that are often out of reach due to their illnesses or medical conditions. Project Dates: 10/01/2017 – 09/30/2018 Total/Direct Cost: $20,000


Department of Emergency Medicine

Dr. Christopher Carey HHS (SAMHSA) via SC DAODAS FAVOR Opioid Recovery Counseling Evaluation (FORCE) Through this project, the GHS ED will work to connect individuals who present with an opioid overdose with a Certified Peer Support Specialist prior to discharge so that recovery support services can be offered and repeat hospital visits related to opioid use can be reduced. Project Dates: 09/01/2017 - 08/31/2018 Total Awarded: $18,187; Direct Cost: $14,550; Indirect Cost: $3,637 Dr. Brandon Dawson Greenville Health Authority via Greenville County EMS Improved Access to Acute Episodic Care through Integrated Prehospital Care Response Through this partnership with Greenville County, GHS will train firefighters to be first responders, which will enhance the prehospital chair of care and improve access to healthcare through standardized response configurations and abilities while improving and expanding the healthcare workforce. Project Dates: 10/01/2017 - 09/30/2021 Total/Direct Cost: $460,000 Clinical Integration

Heather Goss The Duke Endowment Mountain Lakes AccessHealth** Mountain Lakes Access Health focuses on care coordination, patient navigation and case management for long-term health impact. It fulfills this mission by recruiting providers, reducing system fragmentation, identifying eligibility and participant needs, coordinating medical and social service appointments, and data management. Project Dates: 01/01/2018 - 12/31/2020 Total/Direct Cost: $750,000; Cost Share: $379,834 Candice Hipp F. W. Symmes Foundation Community Paramedicine GHS will partner with Greenville County EMS to provide Community Paramedics response vehicles. Project Dates: 12/01/2017 - 11/30/2018 Total/Direct Cost: $120,000 Jennifer Snow USDA via DHEC via USC PASOs - WIC contract 2017-2018 Funding award to provide continued support for the PASOs project in which WIC information is distributed and participants are enrolled into the program. The team will work to document barriers to service delivery and the enrollment process to coordinate effective service delivery and partnership. Project Dates: 10/25/2017 - 06/30/2018 Total/Direct Cost: $15,000


Cancer Institute

Dr. Dave Grisell National Institutes of Health (NIH) via MD Anderson Community-Based, Phase III Trial of acupuncture to treat chronic Xerostomia Xerostomia (dry mouth) is an important and common problem among cancer patients who have received radiation treatment to the head and neck area. Xerostomia often severely impairs patients' quality of life (QOL), and current available treatments have a low success rate. Through this program GHS will evaluate acupuncture as a novel treatment to improve the QOL for cancer patients. Project Dates: 04/01/2017 - 03/31/2018 Total/Direct Cost: $2,800 Department of Internal Medicine

Dr. Meenu Jindal SAMHSA via SC DAODAS via Phoenix Center Screening, Brief Intervention and Referral to Treatment (SBIRT) This annual incremental funding supports the SBIRT project, which seeks to identify patients with potential alcohol or substance abuse issues and connect them to counseling and treatment through the Phoenix Center as part of a national program. Project Dates: 08/01/2017 - 07/31/2018 Total/Direct Cost: $218,091 Dr. Craig Hudak National Institutes of Health (NIH) via Rutgers University Myocardial Ischemia and Transfusion (MINT) - CCC GHS is a site for this study, which seeks to address the fact that in most clinical settings, evidence suggests it is safe to wait to give a blood transfusion. However, for those who have suffered a heart attack, there is a lack of high quality evidence to guide transfusions. Project Dates: 06/01/2017 - 05/31/2018 Total/Direct Cost: $153,000 Michelle Stancil Greenville Health Authority via Clemson University CU Healthy Communities: Integrated Services for Diabetes Prevention and Management in Greenville County* This project will promote diabetes prevention and diabetes control efforts in Greenville County. The specific aims of this project are to 1) improve citizens’ health, 2) reduce hospital visits related to diabetes and prediabetes, 3) provide training and employment opportunities for the emerging workforce, and 4) strengthen the relationship between GHS and Clemson University. Project Start Dates: 09/26/2017 - 09/25/2022 Total Awarded: $488,071; Direct Cost: $443,702; Indirect Cost: $44,369 Dr. Melissa Bailey The Duke Endowment Memory Health Service Expansion - Anderson/Oconee/Pickens This project will improve the health and quality of life for the 14,378+ persons with ADRD and their caregivers who live in the Upstate. By expanding to Oconee County, GHS will be able increase access and diagnostic, healthcare and community services to these underserved populations. Project Dates: 01/01/2018 - 12/31/2020 Total/Direct Cost: $525,000; Cost Share: $505,784

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