THE FIRST POINT OF CARE TESTING WITH QUANTITATIVE IGE RESULTS

RESPIRATORY ALLERGY PANEL ON THE ABIOSCOPE®

The World Health Organization estimates that over 20% of the world population suffers from allergic disease, such as allergic asthma and allergic rhinitis.1

Allergic rhinitis causes inflammation and irritation in the eyes, nose and the upper airway, leads to running or blocked nose, itching throat, sneezing and watery eyes.3

Allergic asthma primarily affects the lower airways, and induces symptoms including wheezing, chest tightness, shortness of breath and persistent coughing.3

Common triggers of respiratory allergic diseases include pollens, house dust mites, molds and animal dander 2

Nearly 35% of respiratory allergy sufferers experience both allergic rhinitis and asthma7

An estimated 500 million people are affected by allergic rhinitis worldwide including

Figure 1 | Respiratory allergens

Figure 3 | Allergic rhinitis and allergic asthma are closely linked

500million people haveallergic rhinitis worldwide, 40% of them are children4

6,320,047

8,460,041

9,754,538

11,480,040

13,709,620

36,602,227

39,031,365

49,703,705

125,427,357

5,859,491

8,264,617

9,328,876

10,040,062

13,657,710

38,317,590

36,605,625

48,360,625

123,273,678

0 50,000,000 100,000,000 150,000,000

Spain

Italy

France

UK

Germany

Japan

US

Top 5 EU

Top 7MMs

20132023

From 2013 to 2023, the total prevalent cases of allergic rhinitis in seven major markets (7 MMs) will increase from 123 million to 125 million.6

In 2013, total prevalent cases of allergic rhinitis in 5 EUs were 49 million, 39% of the 7 MMs. 6

In 2023, the US will have the highest number of allergic rhinitis with 39 million total prevalent cases, followed by Japan with 36 million.6

Figure 2 | Total prevalent cases of allergic rhinitis in 7MMs

Patients with allergic rhinitis averaged 3 additional doctor visits, 9 more prescriptions filled, and $1500 in incremental healthcare costs in 1 year than similar patients without allergic rhinitis.8

The duration and severity of allergic rhinitis have a direct influence on the development of allergic asthma and the likelihood of recovering from it.9

In the US, about 80% of children and about 60% of adults have allergic asthma, about 10 people per day die from asthma.10

383Kdeaths due to asthma every year worldwide12

Allergic Rhinitis + Allergic Asthma

Allergic Rhinitis

Allergic Asthma

35%

10%

55%

DogMolds

Cat

House dust mites

Pollens

IgE test

Total Prevalent Cases of Allergic Rhinitis

The respiratory allergy panel on the Point-of-Care abioSCOPE® for the first time quantifies specific IgE levels in 5 minutes with just a fingerstick.

Molecules are forced into a nanochannel, limiting the travel distance to a few hundreds of nanometres and reducing incubation time to 2 minutes.

A washing step is not needed as the surface-to-volume ratio is extremely high, and non-specific background is negligible.

Figure 4 | Integration of a fluorescent immunoassay (cross-section through a nanofluidic biosensor)

Figure 5 | Overall percent agreement calculated in function of diagnostic made by allergy experts’ panel

IgE assays reached an agreement of 94.6% on the abioSCOPE® vs. reference laboratory method14

Figure 6 | Method comparison: total IgE on the abioSCOPE® (whole blood) vs laboratory gold standard (ImmunoCAP) (plasma)

Abionic's tailored allergy panel solution offers quantified IgE results with up to 14 specfic allergens

Abionic’s patented nanofluidic immunoassay revolutionizes point-of-care diagnostic solutions13

Respiratory allergy panel on the abioSCOPE® provides laboratory quality test results13

28 million restricted activity days and 2 million lost school days per year11

Up to14allergens can be tested at the same time on one panel

House Dust Mites

Der p 1Der p 2

Cat

Fel d 1 Can f 1

Dog

Anti-human

Total IgEAlternaria

Bla g 1,2&5

Cockroaches

Alt a 1

Bet v 1

Birch

Ole e 1

Olive/Ash Tree

Timothy Grass

Phl p 1

Birch/Profilin

Amb a 1

Ragweed Mugwort Bahia Grass Bermuda Grass

Bet v 2 Art v 1 Pas n 1 Cyn d 1

Allergens in development

Currently available allergens

Perc

enta

ge (%

)

94.6 99.1 97.1 95.2 92.4 92.4

0

10

20

30

40

50

60

70

80

90

100

Overall Cat Dander

GrassPollen

Birch Pollen

Dog Dander

House DustMites

Rapid turnaround time 5 minutes from blood sampling to actionable results

Easy to use Simple 4 steps with a blood volume of 50 µl from a fingerstick

Connectivity optionsHL7, Ethernet to HIS/LIS, barcode scanner and QR code

Laboratory quality resultsExcellent correlation with lab testing, high prescision, large assay range

RESPIRATORY ALLERGY PANEL ON THE ABIOSCOPE®

SIMULTANEOUSLY ANALYSES UP TO 14 PARAMETERS

References

abioSCOPE is a trademark of Abionic.© 2020 Abionic

Published by: Abionic SARoute de la Corniche 5

1066 EpalingesSwitzerland

www.abionic.com

1. de Azevedo M.S.P., Innocentin S., F.A. Dorella F.A.et al. “Immunotherapy of allergic diseases using probiotics or recombinant probiotics” J Appl Microbiol. 2013 Aug;115(2):319-332. Allergic Rhinitis Causes https://www.welcomecure.com/diseases/allergic-rhinitis/causes3. Peter K Jeffery,Tari Haahtela “Allergic rhinitis and asthma: inflammation in a one-airway condition” BMC Pulm Med. 2006; 6(Suppl 1): S5. 4. ALK - What is allergy ? https://www.alk.net/your-allergy/what-allergy5. Tackling the Allergy Crisis in Europe - Concerted Policy Action Needed EAACI https://www.eaaci.org/documents/EAACI_Advocacy_Manifesto.pdf6. EpiCast Report: Allergic Rhinitis - Epidemiology Forecast to 2023 https://www.asdreports.com/news-2370/epicast-report-allergic-rhinitis-epidemiology-forecast-20237. Stallergenes Annual Report 2018 http://stallergenesgreer.com/sites/default/files/documents/2018_stagr_annual_report.pdf8. What is the economic burden of allergic rhinitis (hay fever)? https://www.medscape.com/answers/134825-4365/what-is-the-economic-burden-of-allergic-rhinitis-hay-fever9. ALK - What is allergic asthma? https://www.alk.net/your-allergy/what-asthma10. How Pollen Can Be Dangerous: Understanding Allergic Asthma https://www.healthline.com/health-news/pollen-can-be-dangerous-understanding-allergic-asthma#Allergic-asthma 11. Prevalence and Costs of Allergic Rhinitis http://www.metroeastallergist.com/dr-barry-zeffren/prevalence-and-costs-of-allergic-rhinitis/12. Asthma https://www.who.int/news-room/fact-sheets/detail/asthma 13. Putallaz L, van den Bogaard P, Laub P, Rebeaud F. “Nanofluidics Drives Point-of-care Technology for on the Spot Protein Marker Analysis with Rapid Actionable Results” Nanomed Nanotechnol. 2019, Vol. 10 Iss. 5 No: 53614. Roethlisberger S, Karoui O, Mapelli D et al. “Novel Nanofluidic IgE Assay versus a Reference Method: A Real-World Comparison.” Int Arch Allergy Immunol. 2019;180(1):28-36

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