the human genome lander et al. 2001 venter et al. 2001 patil et al. 2001 gabriel et al. 2002 reich...

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The human genome Lander et al. 2001 Venter et al. 2001 Patil et al. 2001 Gabriel et al. 2002 Reich et al. 2001 Sabeti et al. 2002 Yu et al. 2002

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Page 1: The human genome Lander et al. 2001 Venter et al. 2001 Patil et al. 2001 Gabriel et al. 2002 Reich et al. 2001 Sabeti et al. 2002 Yu et al. 2002

The human genome

Lander et al. 2001Venter et al. 2001Patil et al. 2001

Gabriel et al. 2002Reich et al. 2001Sabeti et al. 2002

Yu et al. 2002

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Yu et al. 2002

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Repeats

• Genome size:– Yeast: 12 Mbp– Human: 3.000 Mbp– Amoeba: 600.000 Mbp

• Human:– Coding Sequence: < 5%– Repeats: >50 %

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The Arabidopsis Genome Initiative (2000)

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10% of genome is duplicated100.000 SNPs are derived from paralogous sequences

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tRNA anticodonsFrequency of codon in protein sequences Count of tRNA anticodons

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The human proteome

• 74 % have homologs from other species in database

• Contains 61 % of Drosophila proteome

• Contains 43 % of C.elegans proteome

• Contains 41 % of S. cerevisae proteome

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Human-Mouse

• 1000 7TM receptors – Human: 60% pseudogenes– Mouse: 10% pseudogenes

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