the iatrogenic major bile duct injuries: experience at ibn siena hospital
DESCRIPTION
The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital. MAM Ibnouf AM Masaad. MBDI. Bile duct injury was estimated 1-3/1000 in Open Cholecystectomy 4-6/1000 Laparoscopic Cholecystectomy - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/1.jpg)
The Iatrogenic Major Bile Duct Injuries:
Experience at Ibn Siena Hospital
MAM Ibnouf AM Masaad
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 2: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/2.jpg)
MBDI
Bile duct injury was estimated1-3/1000 in Open Cholecystectomy 4-6/1000 Laparoscopic Cholecystectomy
1- Nuzzo G. Giuliante F. Giovannini,I et al. Bile Duct Injury During Laparoscopic Cholecystectomy. Results of an Italian National Survey on 56 591 Cholecystectomies. Arch Surg. 2005;140:986-992.
2- Windsor JA, Pong J. Laparoscopic biliary injury: more than a learning curve problem. Aust NZ J Surg. 1998; 68: 186-189.
3- Calvete J, Sabater L, Camps B et al. Bile duct injury during laparoscopic cholecystectomy: myth or reality of the learning curve? Surg Endosc. 2000; 14: 608-611.)
4- Kern KA. Medicolegal analysis of bile duct injury during open cholecystectomy and abdominal surgery. Am J Surg. Am J Surg. 1994; 168: 217-222.
5- Howes N, Chagla L, Thorpe M, et al. Surgical practice is evidence based. British Journal of Surgery 1997;84:1220–3. Prof. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 3: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/3.jpg)
• This rate may reach 14/10001,2
• mortality as high as 11/10003.
1- Gronroos J M. Unsuccessful Endoscopic Stenting in Iatrogenic Bile Duct Injury: Remember Rendezvous Procedure. Surgical Laparoscopy, 2007; 17(3):186-189,
2- Gentileschi P, Di Paola M , Catarci M, et al. Bile duct injuries during laparoscopic cholecystectomy. Surgical Endoscopy. 2004; 18 ( 2): 232-236.
3- Buanes T, Mjaland O, Waage A, et al. A population-based survey of biliary surgery in Norway: relationship between patient volume and quality of surgical treatment. Surg Endosc. 1998;12:852-855.Prof. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 4: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/4.jpg)
Learning curve
• “The incidence of BDI significantly decreased with increasing number of LCs performed, ranging from 0.9% for surgeons who had performed fewer than 150 LCs to 0.3% for those who had performed more than 450 LCs”*.
*Howes N, Chagla L, Thorpe M, et al. Surgical practice is evidence based. British Journal of Surgery 1997;84:1220–3.Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 5: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/5.jpg)
Mortality The mean mortality rate in 15 case series composed of a
total of 602 IMBDIs with a follow up period 1-7 years was 17(2.8%)1.
Poor results are associated with:1- delayed referrals,2- biliary peritonitis3- associated vascular injury4-other co-morbid factors resulting in as high as 9.4%
mortality rate2
1- Johnson SR, Koehler A, Pennington LK, Hanto DW. Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy. Surgery. 2000 Oct;128(4):668-77.
2- Flum DR, Koespsell T, Heagerty P et al. Common Bile Duct Injury During Laparoscopic Cholecystectomy and the Use of Intraoperative Cholangiogram: adverse outcome or preventable error. Arch Surg. 2001; 136:1287-1292.
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 6: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/6.jpg)
• The mortality rate in 39 cases of Bisthmus type III and IV was reported to be 25%*.
*Chaudhary A, Chandra A, Negi SS, Sachdev A. Reoperative surgery for postcholecystectomy bile duct injuries. Dig Surg. 2002;19(1):22-7.
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 7: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/7.jpg)
The experience at Ibn sina Hospital
• Period: Jan 1998 to date
• Exclusion criteria:
1- Residual CBD stone retrieved by ERCP
2- Post cholecystectomy bile duct injuries
managed successfully with endoscopic
stenting
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 8: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/8.jpg)
Number: 85 patients
Male: female : 3:82
Mean (±SD) age: 38.6 ± 10.66, range 22- 66 years
Type of surgery: Open Chole 73(85.8%) LC 12(14.2%)
Mode of presentation: Jaundice:54(63.5%) Bile leak:31(36.5%)
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 9: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/9.jpg)
bile leak jaundice Total
Open chole 27 46 73
Lap chole 4 8 12
Total 31 54 85
Massage: High tendency towards over sewing or over clipping bleeders
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 10: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/10.jpg)
Method of diagnosis
• ERCP 47 patients• MRCP 28 “• Both 15 “
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 11: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/11.jpg)
Types of injuries
• Bisthmus III and IV 68 cases
• Bisthmus type II 15 cases
• Unkown 02 cases Massage: Most of the cases are high injuries
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 12: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/12.jpg)
Period of delay: Range 00 days* – 1 year
* 3 occurred at Ibn Siena Hospital: One in
laparoscopic workshop and the second by a surgeon under training and one
by registrar to right bile duct
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 13: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/13.jpg)
Poor referrals reports
MassageERCP does show the surgeon the site and size of the upper stump he should use for reconstruction
• ERCP
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 14: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/14.jpg)
MRCP
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 15: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/15.jpg)
MRCP
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 16: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/16.jpg)
MRCP
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 17: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/17.jpg)
MRCP
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 18: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/18.jpg)
Bisthmus IV: high narrow ducts
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 19: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/19.jpg)
Biliary peritonitis
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 20: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/20.jpg)
Management
Initial drainage 23 patients
Rodney Smith (Mucosal graft) 55(64.7%)
Hepatico-jejunostomy 23(27%)
Repaired over T-tube 2(2.3%)
Died before reconstruction 2(2.3%)
Left abroad 3(3.5%)Prof. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 21: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/21.jpg)
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 22: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/22.jpg)
Post-operative stenting
3 months 58pts
6 months 18pts
1.5-2 months 3pts
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 23: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/23.jpg)
Hospitalization period:
Before surgery: 3-10 days
After surgery: 10 days -3 weeks
Operative time: 2.5 - 4 hours
Massage: reconstruction of IMBDI is technically difficult and has very high costs
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 24: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/24.jpg)
Follow up
Stricture: 22 patients
Specific complications:
Recurrent Cholangitis 15(17.6%)
Biliary cirrhosis: 7(8.2%)
Intra-hepatic duct stones (Redo-surgery) 2 patients
Cirrhosis (Redo-surgery abroad) 1 patients
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 25: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/25.jpg)
Stricture with stones
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 26: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/26.jpg)
Type of surgery and outcome was dictated by the level of injury
complications Rodney-Smith Hepatico-jej T-tube Total
(n=55) (n=23) (n=2) 80
Cholangitis 13 2 … 15(17.6%)
Cirrhosis 6 1 … 7(8.2%)
PE 1 0 … 1(1.2%)*
Septicaemia 0 0 … ….
No complications 35 20 2 57(67%)
* DiedProf. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 27: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/27.jpg)
Outcome after 3 years follow up
No complications 57(67%)
Recurrent Cholangitis 15(17.6)
Cirrhosis 7(8.2%
Pulmonary embolisim 2(2.3%) Died
Septicaemia 2(2.3%) Died
Advanced cirrhosis hepatic failure 1(1.1%
Massage: Morbidity rate 22(25.9%)
Mortality rate 5(5.9%)Prof. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 28: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/28.jpg)
Out come of ligation & transection P 0.001
Bile leak Jaundice Total
(n=54pts) (31pts) 85
Cholangitis 12 3 15
Cirrhosis 6 1 7
PE 1 1
Septicaemia 2 2
No complications 33 29 60
Massage: IMBDI with bile leak tend to have poorer results
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 29: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/29.jpg)
Adverse outcome
Died before reconstruction 2 Patients
Left abroad 3(1.5%)
Massage: In hospital death after reconstruction 1 Patient
Massage: 2 out of 3 Died after reconstruction abroad
Massage: Mortality rate 5(5.9%)
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 30: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/30.jpg)
Where do we stand?Series Number of repairs M&M re-stricture/cholangitis
MacFadyen BV Jr 1998 561 27(4.9%)
Walsh RM 2004 133 46(35%)
Slater K et al 131 2(1.5%) one of them died
Ibn Siena Hospital 85 22(25.9%) five of them died
Chaudhary A et al 41 3(7%) one of them died
Walsh RM et al 1998 34 18(25%)
Johnson SR et al 2000 21 7(33.3%)
Al-Sebaye MI 17 7(41%)
Topal B et al 1999 16 4(25%) one of them died
Karvonen J 2007 14 3(26%) one of them died
Massage: Ibn Sina Series is the 4th biggest series
and the 4th in the rate of complicationsMAM Ibnouf1, A.Majid M. Massaad2 Iatrogenic Major Bile duct Injuries Injury. Sudan JMS Vol. 2, No. 3, Sep. 2007Mohammad A M Ibnouf, A. M. Massaad, Sulaiman S Fediel "Iatrogenic major bile duct injury in Sudan" Sudan Med. J. (19) 3; 2001: 36-39.
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 31: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/31.jpg)
Conclusion1- IMBDI leads to life long morbidity and high
chances for mortality
2- High injuries are common in OC and LC and are difficult to repair.
3- Injuries leading to bile leak prevent ductal dilatation and hence are associated with high rate of re-stricture.
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university
![Page 32: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/32.jpg)
Conclusion4- Stents should be left till maturation of the
fibrous tissue of the anastomotic line matures.
5- Results of reconstructive surgery at Ibn Siena is comparable to reported literature.
6- National Cholecystectomy Registry:
to evaluate the real magnitude of the IMBDI. Prof. MAM Ibnouf, FRCSEd. Omdurman
Islamic university
![Page 33: The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital](https://reader034.vdocument.in/reader034/viewer/2022051215/568148ea550346895db60561/html5/thumbnails/33.jpg)
Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university