The Infectious Diseases InstituteKampala, Uganda

The Infectious Diseases InstituteKampala, Uganda

InfoPoverty World Conference

United Nations

InfoPoverty World Conference

United Nations

Robert L. MallettSenior Vice President

Corporate AffairsPfizer Inc

2

What We DoWhat We Do

Source: PhRMA, based on data from Center for the Study of Drug Development, Tufts University, 1995

5,000–10,000Screened

5,000–10,000Screened

250Enter Preclinical

Testing

250Enter Preclinical

Testing

5Enter

Clinical Testing

5Enter

Clinical Testing

1Approved by

the FDA

1616

1414

1212

1010

88

66

44

22

00

Phase II100–300 Patient Volunteers Used to Look for Efficacy and Side Effects

Phase III1,000–5,000 Patient Volunteers Used to

Monitor Adverse Reactions to Long-term Use FDA Review Approval

Additional Post-marketing Testing

Phase I 20–80 Healthy

Volunteers Used to Determine Safety and

Dosage

Preclinical TestingLaboratory and Animal Testing

Discovery(2–10 Years)

Compound Success Rates by Stage

Compound Success Rates by StageYears

3

• Effective Social Investment• We Focus on Where We Add the Greatest Value

– Long-Term Commitment to Health Problems– Focus on Achievable,

Measurable Health Outcomes– Leverage the Full Resources

of the Company– Fostering Innovative Approaches

to Public Health Challenges• We Have More to Offer Than Money

– Medicines, Organizational Influence, Leadership, and Our People

• We Cannot Do It Alone– We Work in Partnership

• Effective Social Investment• We Focus on Where We Add the Greatest Value

– Long-Term Commitment to Health Problems– Focus on Achievable,

Measurable Health Outcomes– Leverage the Full Resources

of the Company– Fostering Innovative Approaches

to Public Health Challenges• We Have More to Offer Than Money

– Medicines, Organizational Influence, Leadership, and Our People

• We Cannot Do It Alone– We Work in Partnership

What We BelieveWhat We Believe

Guiding PrinciplesGuiding Principles

4

How We HelpHow We Help

Access to MedicinesAccess to Medicines

• Infrastructure Development

• Health Provider Training

• Company Expertise

• Patient Education

• Pfizer People

• Infrastructure Development

• Health Provider Training

• Company Expertise

• Patient Education

• Pfizer People

Global Health: Systemic Improvements in Building Capacity

5

Health Care in Uganda: Challenges and Opportunities Health Care in Uganda: Challenges and Opportunities

• Absence of Primary Health Care Infrastructure

• Lack of Trained Health Care Professionals

• Transient, Mobile Patient Populations

• Lack of Equipment and Medical Facilities

• Vertical Programs

• Absence of Primary Health Care Infrastructure

• Lack of Trained Health Care Professionals

• Transient, Mobile Patient Populations

• Lack of Equipment and Medical Facilities

• Vertical Programs

• Responsive, Engaging Government

• Existing Medical School with Significant HIV/AIDS Expertise

• Stable Environment

• Resources and International Donors

• Responsive, Engaging Government

• Existing Medical School with Significant HIV/AIDS Expertise

• Stable Environment

• Resources and International Donors

OpportunitiesOpportunitiesChallengesChallenges

6

Infectious Diseases Institute, Kampala, UgandaInfectious Diseases Institute, Kampala, Uganda

Goal: To Build and Sustain Regional Clinic, Laboratory and Medical Training Center for the Diagnosis, Treatment and Prevention of HIV/AIDS

7

Model PartnershipModel Partnership

• Makerere University in Kampala– One of the Leading Medical Schools on the Continent

• San Francisco AIDS Foundation/Pangaea– Program Administration and Project Manager for Construction

• Infectious Diseases Society of America (IDSA)– Developed Intensive Month-Long HIV/AIDS Training

Curriculum and Provides Trainers

• The AIDS Support Organization (TASO) – Largest Indigenous Organization in Africa Providing Patient

Counseling and Support

• Pfizer– Financial Support and Technical Assistance (e.g. Pfizer Engineers and IT Support; Medicines; Pfizer Global Health Fellows)

• Makerere University in Kampala– One of the Leading Medical Schools on the Continent

• San Francisco AIDS Foundation/Pangaea– Program Administration and Project Manager for Construction

• Infectious Diseases Society of America (IDSA)– Developed Intensive Month-Long HIV/AIDS Training

Curriculum and Provides Trainers

• The AIDS Support Organization (TASO) – Largest Indigenous Organization in Africa Providing Patient

Counseling and Support

• Pfizer– Financial Support and Technical Assistance (e.g. Pfizer Engineers and IT Support; Medicines; Pfizer Global Health Fellows)

8

Matching Needs to ResourcesMatching Needs to Resources

IDI Technology Needs

• Infrastructure/Wiring

• Integration of Clinical Laboratory System

• Identification and Implementation of an Electronic Record Keeping System

• Installation of a Research Database to Administer Data Collection for Clinical Trials

• Creation of a Clinical Training Program for New Physicians

IDI Technology Needs

• Infrastructure/Wiring

• Integration of Clinical Laboratory System

• Identification and Implementation of an Electronic Record Keeping System

• Installation of a Research Database to Administer Data Collection for Clinical Trials

• Creation of a Clinical Training Program for New Physicians

Donors

($1.8M in IT support )

• Pfizer

• Microsoft

• Cisco

• SAS

• Oracle

• Hewlett Packard

• Elsevier Science

• Skyscape

• PALM Inc

Donors

($1.8M in IT support )

• Pfizer

• Microsoft

• Cisco

• SAS

• Oracle

• Hewlett Packard

• Elsevier Science

• Skyscape

• PALM Inc

9

Impact of Infectious Diseases InstituteImpact of Infectious Diseases Institute

Training

• 200 Physicians Trained Each Year

Treatment

• 3,000+ Patients Receive Regular Care

Operational Research

• New Studies on Adherence

Prevention and Outreach

• Counseling for Patients

• AIDS Center Provides Information for Physicians

Training

• 200 Physicians Trained Each Year

Treatment

• 3,000+ Patients Receive Regular Care

Operational Research

• New Studies on Adherence

Prevention and Outreach

• Counseling for Patients

• AIDS Center Provides Information for Physicians

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Critical But Unforeseen Benefits Critical But Unforeseen Benefits

• Workplace Safety Program– Transferring World Class Health & Safety Standards

• Makerere School of Architecture– Students Benefiting From Project Engineering and

Architecture

• Local Procurement of Resources– Support Kampala Economy

• Creating Entrepreneurial Opportunities– Local Contracting Company Won Bid to Construct

New British High Commission

• Sharing Best Practices– Pfizer Promoting Lessons Learned

• Workplace Safety Program– Transferring World Class Health & Safety Standards

• Makerere School of Architecture– Students Benefiting From Project Engineering and

Architecture

• Local Procurement of Resources– Support Kampala Economy

• Creating Entrepreneurial Opportunities– Local Contracting Company Won Bid to Construct

New British High Commission

• Sharing Best Practices– Pfizer Promoting Lessons Learned