the ins and outs of human challenge studies - who€¦ · the ins and outs of human challenge...
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The ins and outs of
Human Challenge studies
John Oxford DSc FRCPE
Professor of Virology,
Queen Mary College, London
Influenza Specific Protein
Responses- Baseline
SUMMARY
Technical
1.Virus wild type to GMP level.
2.Sourced by WHO laboratory (A/Bergen/2016?)
3.HI antibody of <15 still important.
Volunteers
1.Healthy, young.
2.Older and even asthmatic.
3.Attention to nearby A&E department.
4.Tamiflu stock
Ethics
1. Hippocratic oath.
Pathology/Safety
1.Phase I study of drug/vaccine.
2.Virus is pre-studied and titrated.
3.However, the mixture is novel.