the ins and outs of human challenge studies - who...john s oxford and juliette r oxford* blizard...
TRANSCRIPT
![Page 1: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/1.jpg)
The ins and outs of
Human Challenge studies
John Oxford DSc FRCPE
Professor of Virology,
Queen Mary College, London
![Page 2: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/2.jpg)
![Page 3: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/3.jpg)
![Page 4: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/4.jpg)
![Page 5: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/5.jpg)
![Page 6: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/6.jpg)
![Page 7: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/7.jpg)
![Page 8: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/8.jpg)
![Page 9: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/9.jpg)
![Page 10: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/10.jpg)
![Page 11: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/11.jpg)
![Page 12: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/12.jpg)
![Page 13: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/13.jpg)
![Page 14: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/14.jpg)
![Page 15: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/15.jpg)
![Page 16: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/16.jpg)
![Page 17: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/17.jpg)
![Page 18: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/18.jpg)
![Page 19: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/19.jpg)
![Page 20: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/20.jpg)
![Page 21: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/21.jpg)
![Page 22: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/22.jpg)
Influenza Specific Protein
Responses- Baseline
![Page 23: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/23.jpg)
![Page 24: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/24.jpg)
![Page 25: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/25.jpg)
![Page 26: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/26.jpg)
![Page 27: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/27.jpg)
SUMMARY
Technical
1.Virus wild type to GMP level.
2.Sourced by WHO laboratory (A/Bergen/2016?)
3.HI antibody of <15 still important.
Volunteers
1.Healthy, young.
2.Older and even asthmatic.
3.Attention to nearby A&E department.
4.Tamiflu stock
Ethics
1. Hippocratic oath.
Pathology/Safety
1.Phase I study of drug/vaccine.
2.Virus is pre-studied and titrated.
3.However, the mixture is novel.
![Page 28: The ins and outs of Human Challenge studies - WHO...John S Oxford and Juliette R Oxford* Blizard Institute Of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology](https://reader034.vdocument.in/reader034/viewer/2022050516/5fa031c6de52683ac8467cad/html5/thumbnails/28.jpg)