the kidney & collecting system diseases of tubules & interstitium: 1. infectious: acute...
DESCRIPTION
n Glomeruli Not involved n Suppurative inflammation (Abscess) –Interstitium: Neutrophils infiltrate –Tubules (WBCs Casts) Acute PyelonephritisTRANSCRIPT
The Kidney &The Kidney &Collecting SystemCollecting System
Diseases of Tubules & Interstitium:1.1. Infectious:Infectious:
Acute PyelonephritisChronic Pyelonephriris
2. Non-infectious:2. Non-infectious:
Drug-Induce Interstitial Nephritis• Allergic• Analgesic
Acute Tubular Necrosis
Acute PyelonephritisAcute PyelonephritisGross:
• One /or both Kidneys involved• Normal or/enlarged• Microabscesses in both cortex and medulla (hematogenous)
Glomeruli Not involved
Suppurative inflammation(Abscess)– Interstitium: Neutrophils infiltrate– Tubules (WBCs Casts)
Acute PyelonephritisAcute Pyelonephritis
The Kidney &The Kidney &Collecting SystemCollecting System
Diseases of Tubules & Interstitium:1.1. Infectious:Infectious:
Acute PyelonephritisChronic Pyelonephriris
2. Non-infectious:2. Non-infectious:
Drug-Induce Interstitial Nephritis• Allergic• Analgesic
Acute Tubular Necrosis
Chronic Pyelonephritis &Chronic Pyelonephritis &
Reflux NephropathyReflux Nephropathy
Interstitial inflammation & Scarring of Renal Parenchyma Interstitial inflammation & Scarring of Renal Parenchyma
Gross Scarring & Deformity of Pelvicalyceal SystemGross Scarring & Deformity of Pelvicalyceal System
Important cause of Important cause of Chronic Renal FailureChronic Renal Failure
Chronic PyelonephritisChronic Pyelonephritis
Morphology:Morphology:
The Kidney &The Kidney &Collecting SystemCollecting System
Diseases of Tubules & Interstitium:1.1. Infectious:Infectious:
Acute PyelonephritisChronic Pyelonephriris
2. Non-infectious:2. Non-infectious:
Drug-Induce Interstitial Nephritis• Allergic• Analgesic
Acute Tubular Necrosis
Drug-induced Interstitial NephritisDrug-induced Interstitial Nephritis
1. Acute drug-induced Interstitial Nephritis ARFARF
2. Analgesic Nephropathy CRFCRF
1) Acute drug-induced Interstitial Nephritis1) Acute drug-induced Interstitial Nephritis
Morphology:Morphology:
2) Analgesic Nephropathy2) Analgesic Nephropathy
Drugs:Drugs:
“Combinations” of “large quantities” for “long periods”
Phenacetin
Aspirin
Acetaminophen
Caffeine
Codeine
Leading to Renal Papillary Necrosis & Interstitial Nephritis
The Kidney &The Kidney &Collecting SystemCollecting System
Diseases of Tubules & Interstitium:1.1. Infectious:Infectious:
Acute PyelonephritisChronic Pyelonephriris
2. Non-infectious:2. Non-infectious:
Drug-Induce Interstitial Nephritis• Allergic• Analgesic
Acute Tubular NecrosisAcute Tubular Necrosis
Acute Tubular Necrosis (ATN)Acute Tubular Necrosis (ATN)
Clinico-Pathological entity Characterized by:Clinico-Pathological entity Characterized by:
Destruction of tubular epithelial cells Destruction of tubular epithelial cells
Acute Renal FailureAcute Renal Failure
The The most common causemost common cause of of acute renal failureacute renal failure
Reversible renal lesionsReversible renal lesions
Cont.Cont. Acute Tubular Necrosis (ATN)Acute Tubular Necrosis (ATN)
Morphology:Morphology: