the latin america and caribbean consortium on dementia
TRANSCRIPT
The Latin America and Caribbean Consortium on Dementia (LAC-CD): Towards a common voice across the region
Agustin Ibañez
Miami, May 2019
Disclosures
I am partially supported by CONICET, CONICYT/FONDECYT Regular (1170010 and 1171200), FONCyT-PICT 2017-1818, FONCyT-PICT 2017-1820, FONDAP 15150012, INECO Foundation, The Global Brain Health Institute (GBHI), the Interamerican Development Bank (IDB) and NHI R01 AG057234-01A1.
Antecedents How we got here?
LAC-CD TodayNational Representatives
Current Initiatives
Other ongoing projects
Potential synergies to explore
ConclusionsTurning regional challenges into advantages by
integrating multiples voices
Outline
© GBHI 2018 3
Antecedents
15 40 80 160+Membership
Antecedents Working on it: A shared voice across the region
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The knowledge-to-action framework Implement priority actions in the context of global and rapidly changing dementia challenges
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Promoting a dementia culture regionally
Facing lack of awareness and epidemiological data
Improving health systems
Seeking and securing governmental and
international support
Towards scientific networks and platforms in
the region
Translational implementations
Situating the biomarkers agenda in the region
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Mario Alfredo Parra1, Sandra Baez#2, Lucas Sedeño#3, Cecilia Gonzalez Campo#4, Hernando Santamaría-García#5, Ivan Aprahamian*6, Paulo HF Bertolucci*7, Julian Bustin*8, Maria Aparecida Camargos Bicalho*9, Carlos Cano-Gutierrez*10, Paulo Caramelli*11, Marcia L. F.Chaves*12, Patricia Cogram*13, Bárbara Costa Beber*14, Felipe A. Court*15, Leonardo Cruz de Souza*16, Nilton Custodio*17, Andres Damian*18, Myriam De la Cruz*19, Roberta Diehl Rodriguez*20, Sonia Maria Dozzi Brucki*21, Lissete Duque Peñailillo*22, Henry Willy Engler*23,Marcia Lorena Fagundes Chaves*24, Lais Fajersztajn*25, Gonzalo A. Farías*26, Fernanda G. De Felice*27, Ignacio Fernandez Mata*28, Raffaele Ferrari*29, Fabricio Ferreira de Oliveira*30, Sergio T. Ferreira*31, Ceres Ferretti*32, Marcio Luiz Figueredo Balthazar*33, NorbertoAnizio Ferreira Frota*34, Patricio Fuentes*35, Adolfo M. García*36, Patricia J. Garcia*37, Fábio Henrique de Gobbi Porto*38, Christian Gonzalez-Billault*39, Alejandra Guerrero Barragan*40, David Huepe*41, Fabricio Joao Pio*42, Claudia Kimie Suemoto*43, Renata Kochhann*44,Silvia Kochen*45, Fiona Kumfor*46, Serggio Lanata*47, Leticia Lessa Mansur*48, Mirna Lie Hosogi*49, Patricia Lillo*50, Jorge J Llibre Guerra*51, David Lira*52, Francisco Lopera*53, Oscar Lopez*54 ,Patricia Cristina Lourdes Solis*55, Renata Eloah de Lucena Ferretti-Rebustini*56,Facundo Manes*57, Jeronimo Martin Ramirez*58, Diana Matallana*59, Lingani Mbakile-Mahlanza*60, Alyne Mendonça Marques Ton*61, Ronnielly Melo Tavares*62, Bruce Miller*63, Eliane C Miotto*64, Sebastian Moguilner*65, Laura Morelli*66, Graciela Muniz-Terrera*67, LuisArnoldo Muñoz-Nevárez*68, Ricardo Nitrini*69, David Orozco*70, Maira Okada de Oliveira*71, Olivier Piguet*72, Maritza Pintado Caipa*73,Stefanie Danielle Piña Escudero*74, Lucas Porcello Schilling*75, Yakeel Quiroz*76, André Luiz Rodrigues Palmeira*77, Mônica SanchesYassuda*78, Jose Manuel Santacruz-Escudero*79, Rodrigo Bernardo Serafim*80, Jerusa Smid*81, Andrea Slachevsky*82, Cecilia Serrano*83, Marcio Soto-Añari*84, Leonel Tadao Takada*85, Lea Tenenholz Grinberg*86, Antonio Lucio Teixeira*87, Maira Tonidandel Barbosa*88,Teresa Torralva*89, Dominic Trépel*90, Rodrigo A. Vasquez*91, Noelia Weisstaub*92, Agustin Ibanez †93
LAC-CD Today• +160 members
• 15 countries
• Integration
• Strategic initiatives
• Visibility + web + multicenter initiatives
• Local synergies
• International oportunities
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National Representatives from 10 countries
Brazil - Nitrini, Ricardo
Chile - Slachevsky, Andrea
Colombia - Lopera, Francisco
Costa Rica - Leon, Jorge
Cuba - Llibre, Juan J:
Ecuador - Unaucho, Martha
Mexico - Sosa, Ana Luisa
Peru - Custodio, Nilton
Uruguay - Damian, Andres
Argentina - Ibañez, Agustin
Behavioral Insights Team for Social Protection and Health Policies: A lifespan approach
Agencies Research groups External partners
BID-RPG: To develop a multimodal regional dementia platform for:
Assessment Maximize resource utilization and access
LAC Consensus and Manual Congress and divulgation with regional journals Consolidation of a regional network for translational neuroscience.
Translation and Implementation Platform
Regional consortium for research and improved assessment: Software for Multimodal PA assessment, Algorithms to improve the diagnosispost-diagnosis support, training, and Intervention programs.
Levels of Action Issues Suggested Strategies
Regional big-data consortium, Sofware for Multimodal PA assessment, Algorithms to improve the diagnosisBasic standards of and guidelines for diagnosis
US-South American initiative for genetic-neural-behavioral interactions in human neurodegenerative research
(a) Establish genetic risk to AD and FTD in diverse SAC cohorts;(b) Test whether patients from SAC and the US can be discriminated after accounting for how SES affects cognitive
and brain imaging signatures; and(c) Determine genetic, cognitive, cerebral, and socioeconomic factors that discriminate among SAC vs. US patients.
Total sample:>3000 participants
1500 controls
750 AD patients
750 FTD patients
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Other ongoing initiativesComputational approaches multimodal/multicenter neuroimaging
Multicenter studies of neurocognitive biomarkers across regions
Horizontal communication and self-organized initiatives
Latin America and Caribbean interest group
GBHI-AA project (in prep.) Networking in the region
Potential synergies to explore
ConclusionsTurning regional challenges into advantages by integrating multiples voices• Heterogeneity and multinational approaches.
• Learning from genetic isolates and unique populations.
• SES, SDH and Influence of complex environmental factors.
• Regional Clinical Trial Program.
• Nonpharmacological interventions and lifestyle factors.
Sustained dialogue to (1) translate differences into shared concerns and actions, (2) raise awareness of where knowledge and resources should be more quickly deployed, (3) promote an equitable growth of those in the least favorable positions, and (4) guide critical regional development
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