Catalyzing Collaborations Outside NIH

Translation is a team sport

Requires tof performers with a wide variety of different expertise to work together to a common goal

Catalyzing Collaboration within NCATS

Across the Translational Spectrum

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Clinical and Translational Science Awards Led by NCATS Division of Clinical Innovation

CTSAs:

• Support a national consortium of medical research institutions

• Work together to improve the way clinical and translational research is conducted nationwide

Recent CTSA Awards Announcement

Examples of translational problems for

next-gen CTSA focus

• Data interoperability/governance

• Clinical trial networks

• EHRs for research

• IRB federation

• Patient recruitment

DHHS-NIH

ORDR/NCATS, NINDS,

NIAMS, NICHD, NHLBI,

NIDDK, NIDCR, NIAID, NCI

The Data Management and

Coordinating Center

Coalition of Patient

NCATS DPI Staff

• Drug: IT Cyclodextrin

• Collaborators

ü NIH

Tissue Chips for Drug Screening, a.k.a.: Microphysiological Systems (MPS) Program

• Goal ü Develop chip to screen for safe, effective drugs

Á Liver, heart, lung, other cell types

Á Designed for multiple different readouts

• NIH, DARPA contribute ~$70M 8ach over 5 y8ars ü NCATS and DARPA independently manage, fund separate

MPS Program Stem Cell Research and Therapy Special Issue

• Stem Cell Research and Therapy published a

supplement about Tissue Chip program on

December 20, 2013

• Introduction authored by Margaret Sutherland,

(NINDS), Dan Tagle, and Kristin Fabre (NCATS)

• 18 reviews authored by Tissue Chip grantees

• Freely available at:

http://stemcellres.com/supplements/4/S1.