The new age GastroprotectantThe new age GastroprotectantThe new age GastroprotectantThe new age Gastroprotectant

Zinc CarnosineZinc CarnosineZinc CarnosineZinc CarnosineZinc Carnosine

ZINC CARNOSINE

Effect of Zinc Carnosine on epigastric pain

Night

Fasting

After meals

Disappearance rates of pain (%)

53.3

76.9

90.9

0 20 40 60 80 100

1

1.http://www.lef.org/magazine/mag2006/dec2006_report_stomach_02.htm 2.A natural approach to ulcer treatment, In Ulcer free by Halpern GM. 2004, 145-166

Clinical efficacy

Zinc Carnosine has been used widely in human

clinical trials for over a decade. In clinical trials

enrolling a total of 691patients, 70% experienced

remarkable improvement in symptoms and 65%

of patients demonstrated evidence of healing on

gastrointestinal imaging tests after eight weeks

of using Zinc Carnosine. There were remarkable

improvements in objective outcomes as well as subjective symptoms such as heartburn, 1nausea,vomiting, belching and bloating.

In a meta-analysis of studies done on Zinc Carnosine, there were no adverse effects from the

supplement. None of the patients with side effects required further evaluation or treatment.

Zinc Carnosine, offers an ideal supplement to be added with proton pump inhibitors and NSAIDs. PPIs

have been demonstrated to be effective in symptom relief and prevention of relapse of peptic ulcers by

reducing the acid secretion. On the other hand, Zinc Carnosine produces visible changes in stomach

integrity.

Clinical safety of Zinc Carnosine

Combination therapy with Zinc Carnosine

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ZINC CARNOSINE ZINC CARNOSINE THE NEW AGE GASTROPROTECTANT

Zinc Carnosine

Zinc Carnosine offers a new dimension to the treatment of acid

peptic disorders due to its ability to strengthen the gastric

mucosa and protecting the stomach lining against acid 1 damage. Zinc Carnosine is a chelate of zinc and L- carnosine;

having powerful antioxidant, tissue-healing and mucosal-1supportive functions.

Component of various enzymes required in the

maintenance of structural integrity of proteins

Zinc

l

Common causes of mucosal

destruction

Excessive acid secretion

NSAID usage

Helicobacter pylori

Smoking

Alcohol

l

l

l

l

l

This causes gastritis and eventual ulcerations.The common diseases in which the gastrointestinal

mucosa is damaged are peptic ulcer and gastritis.

The primary goal of acid peptic disorders would be to reduce the acid secretion which can reduce

gastritis and bring about healing of the ulcers. But little attention has been paid towards the protection of

the gastric mucosa, primarily due to lack of options for the same. In this regard, PPIs have dominated the

treatment course due to their excellent clinical efficacy in reducing hypersecretion of acid. However, the

improvement of gastrointestinal lesions would be much better and faster if the PPIs are combined with a

drug which will heal the lesions.

N

N

ZnN

NH

H

H2

0

0

0n

ZINC CARNOSINE

Gastric mucosal barrier and gastrointestinal

health

Gastrointestinal mucosal damage

The gastrointestinal mucosa :

Offers protection from digestive acid, pepsin, bile

acids, and proteolytic enzymes

Ensures healthy gastric function

Prevents irritation and auto-digestion of mucosa by

gastric secretion

Breakdown and disruption of the gastric mucosa may be

caused by gastric stress due to:

Excessive acid secretion,

NSAID usage,

Infection with Helicobacter pylori

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

l

Catalytic, structural or regulatory roles in more than 200 metalloenzymes.

Composed of the amino acids histidine and B-alanine

Found in relatively high concentrations in the skeletal muscle, heart muscle, and in the brain.

When zinc and L-carnosine are linked by chemical bond in a single molecule, or chelated, their tissue-

healing effects become even more remarkable.

Successful pharmaceutical product in Japan since 1994 for the treatment of stomach and

gastrointestinal disorders

Large body of animal safety and efficacy/mechanism of action research

Supports the inhibition of Helicobacter pylori (H. pylori)

Numerous research studies and more than 12 years of human experience

US FDA approved as dietary ingredient

Increases production of insulin-like growth factor-1 (IGF-1)

Promotes gastric epithelial wound repair

Inhibits production of pro-inflammatory interleukin-8

Prevents inflammatory white blood cells from adhering to epithelial cells

Minimises gastric stress due to free radicals

Being a chelate, Zinc Carnosine is not destroyed in the acidic pH of stomach. On oral administration,

Zinc Carnosine adheres and bind to gastric ulcer site.

L-carnosine, which has wound healing ability is released on the ulcer lesion.

Simultaneously, Zinc, which has a protective effect on membranes, penetrates into the ulcer to ease

inflammation.

Zinc carnosine has a slow dissociation rate because of which it is not easily removed form the ulcer

site of stomach.

The slow dissociation rate of Zinc Carnosine in gastric juice due to the polymeric character is

essentially important because the prolonged existence in the stomach maintains the healing effect 2for a long time.

L-carnosine

Accelerates healing of ulcers

Anti-inflammatory effect

Antioxidant effect

1Zinc-Carnosine - The new age gastroprotectant

2Mechanism of action

Penetration of Zinc Carnosine inside gastric tissue