Contact Information:

Head Office: T. +82-2-572-1331 F. +82-2-572-1060

1st Factory: T. +82-70-4735-0035 F. +82-70-4735-0040

Email: global@jetema.com

Address: #502, Daewoo Frontier Valley I, 16-25 Dongbaekjungang-ro,

16Beon-gi, Giheung-gu, Yongin-si, Gyeonggi-do, Korea

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The New Line Contouring Solution for Face and Body

Combination technique of HA filler and Thread

2 3

The New Combination of Filler and Thread

The SMART solution of safe‚ minimally invasive procedure helps “Lifting and Volumizing” anti-aging for the ideal result in a short time.

epiticon is a scaffold that promotes fibroblast activity and helps to trigger collagen neo genesis in a soft tissue. e.p.t.q. is a supplement(=filler) at the defective site of soft tissue.

‘epiticon x e.p.t.q.’ solution gives ‘Lifting & Volumizing’ effect at once.

Safe biodegradable material

Strictly controlled manufacturing process

Low side-effect

Safety

No surgery! Simple and easy minimally invasive procedure

No aftercare is neededMinimally invasive

Ideal appearance by the simultaneous effect of “Lifting & Volumizing”

Customized design & procedure for patient

Simple reconstruction and easy repeated injection

Anti-aging

Cost effectiveness is increased by the mutual supplementation procedure

Long duration due to the dual action of “filler & thread”

High patient satisfaction by total anti-aging solution

Result

Total procedure time of 30 minutes

Short downtime and recovery timeTime

e.p.t.q.HA

filler

epiticonPDO, PCL

threadSMART solution

“Highly augmented results are observed when threads are combined with fillers.”

e.p.t.q. filler: supplement role epiticon thread

: scaffold role

4 5

Exquisite Technique, Contented for Safety with The 9 Essential Process

2. Less than 0.1 EU/ml endotoxin3)

Endotoxin level of all e.p.t.q. are produced with less than 0.1EU/mL (much more less than the criterion of EP standard) according to Jetema’s strict manufacturing process.Modification and cross-linking paramenters in hyaluronic acid hydrogels-Definitions and analytical methods

Lennart Kennea, Suresh Gohila,*, Eva M. Nilssonb, Anders Karlssonb, David Ericssonb,1, Anne Helander Kenneb, Lars Ⅰ. Nordb aDepartment of Chemistry, Uppsala BioCenter, Swedish University of Agriculyural Sciences, P.O. Box 7015, SE-750 07 Uppsala, SwedenbQ-Med AB, Seminariegatan 21, SE-752 28 Uppsala, Sweden

MoD (Degree of Modification) is the scale for modification of HA by BDDE.

MoD = Full cross-linked BDDE + Pendant type BDDEThe lowest MoD makes best safety requirement.

Residual BDDE is one of the critical issue about the side effects of the filler. It can provoke swelling, allergic symptom, and cancer.

1.Correlation between filler quality and MoD

2. MoD level test1)

e.p.t.q. Lidocaine S100 e.p.t.q. Lidocaine S300 e.p.t.q. Lidocaine S500 J filler of A Y filler of L N filler of M

MoD (%) 1.45 1.98 2.72 7.68 8.07 11.23

e.p.t.q has the lowest MoD level among monophasic fillers.

The Lowest MoD Level for Safety

The 9 Essential Process Excellent Quality

Fully reacted BDDE Pendant BDDE Deactivated BDDE

Incomplete Cross-linking HA gel e.p.t.q. HA Gel

3. Excellent cohesiveness4)

e.p.t.q. S500 : 0.5583Y of L company : -0.1917

Gap(mm)

Force(N)

0.1

0

-0.1

-0.2

-0.3

-0.4

-0.5

-0.6

0 2 6 8 10 12

-0.8

N of M company : -0.4479

Gap(mm)

Force(N)

0.1

0

-0.1

-0.2

-0.3

-0.4

-0.5

-0.6

0 2 6 8 10 12

-0.8

Gap(mm)

Force(N)

0.1

0

-0.1

-0.2

-0.3

-0.4

-0.5

-0.6

0 2 4 6 8 10 12

-0.8

Gap(mm)

V of J company : -0.6433

Force(N)

0.1

0

-0.1

-0.2

-0.3

-0.4

-0.5

-0.6

0 2 4 6 8 10 12

-0.8

The hyaluronic acid filler e.p.t.q. is produced according to the “The 9 Essentials Process” which is strictly controlled that promises an exquisite product that meets stringent safety standards.

The Ⅸ Essential Process1. Safety of raw ingredients managed in exclusive lines2. High purity HA content for duration and prevention of swelling3. High viscoelasticity for exquisite lift up4. Homogeneous particle implementation technology to complete exquisite molding5. No detection of residual chemical catalyst substance(BDDE) through the complete crosslinking process6. Aseptic manufacturing environment to prevent side effects7. Less than 0.1 EU/ml of endotoxin8. Minimizes pain with the same pH and osmotic pressure as the human body9. Optimized injection pressure for exquisite procedures

1.Ideal complex viscosity2)

e.p.t.q.’s ideal viscoelasticity lifts up the tissue enabling easy molding and natural beautiful shape.

Product Pa.s(1Hz)

E Filler of H (Ultra Volume Plus with Lidocaine) 48

Y Filler of L (Volume Plus with Lidocaine) 49

J Filler of A (Ultra Plus XC with Lidocaine) 45

R Filler of A (Sub-Q Plus with Lidocaine) 55

S 500 59E Filler of H

80

60

40

20

0

Y Filler of LJ Filler of A

R Filler of A

E Filler of H

Y Filler of L

J Filler of A

R Filler of A

2,3) Data on Jetema

4) HA(Hyaluronic acid) dermal filler rheology comparing test, Chung-Ang University Hospital Korea 2017 1) HA(Hyaluronic acid) dermal filler rheology comparing test, Chung-Ang University Hospital Korea 2017

Cohesiveness can be defined as a resistance to compression/stretching forces in a vertical plane once the product is implanted.e.p.t.q. has excellent cohesiveness which makes the molding easier and migration less likely.

productendotoxin

(EU/

mL)

R Filler of G0.5

R Filler of A0.5

T Filler of T0.1

e.p.t.q.0.045

Endotoxin0.6

0.5

0.4

0.3

0.2

0.1

0

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The World’s First Dual Action Thread

conventional cog thread (bi-directional) epiticon contouring thread

25mm

92mm 70mm

25mm

60mm

155mm

187mm

80mm

100mm

70mm

Safe Cannula Tip that reduces vascular injuries

W/L - blunt cannula

60mm64 Multi Anchoring Points

19G cannula

90mm96 Multi Anchoring Points

18G cannula

Lifting Gathering Tightening Smoothing

Fixation by sending the thread upward

Fixation by gathering the skin

Fixation at the injection point

Fixation by smoothing �ne wrinkles and revitalizing

4. The way of dual action

1. New patented structure5) Patented Structure (WO 2017/131416A2)Each unit of epiticon carries out a dual action and fixation.

2. Immediate effect Each unit of epiticon has an immediate effect of

dual action of lifting and fixing.

3. Delayed effect

Even if the thread breaks or partially melts, constant fixing effect continues by the multi anchoring points constituted of units.

“Non-heat treatment press molding Method8)” sets the manufacturing temperature to less than the raw materials’ melting point.

Maintains the unique physical properties of the raw materials of the suture to keep high tensile strength and durability.

Simple and Easy of Use

The tensile force6) is more than 5 times higher7) than previously existing cutting threads.

Simple and easy procedure with thread with blunt cannula makes the safe procedure result.

Epiticon is individually packed in blisters to maximize stability and to prevent moisture and/or contamination.

Previous Cutting Thread epiticon

8.0N

44.8N

Strong Tensile Force6)Innovative Dual Action

5) International patent WO2017/131416

6) KTR (Korea Testing & Research Institute) tensile load test MSK-2018-0003337) Data on file 20188) Product standard report 2018

Points that are fixed to the skin tissue

The part of the unit that has opposite resistance

Lift-up Fixation

Unit

2.0mm 2.0mm 2.0mm

Lift-up Fixation

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Lift-up with epiticonLift-up with epiticon

Before

Before

epiticonX

e.p.t.q.

epiticonX

e.p.t.q.

Before

Before

epiticonX

e.p.t.q.

epiticonX

e.p.t.q.

Volume-up with e.p.t.q.Volume-up with e.p.t.q.

FACE BREAST

The SMART solution can be sophisticated according to the patient’s condition, resulting in natural volume and younger look.

Simultaneous ‘Lifting and Volumizing’ effect

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Product Specification

Cross-inking level Gel Texture Concentration Needles Injection Depth

e.p.t.q. S100 ●○○ HA 24mg/ml 27G, 30G Superficial / Mid dermis

e.p.t.q. S100lidocaine

●○○ HA 24 mg/mlLidocaine 0.3% 27G, 30G Superficial / Mid dermis

e.p.t.q. S300 ●●○ HA 24mg/ml 27G Mid / Deep dermis

e.p.t.q. S300lidocaine

●●○ HA 24 mg/mlLidocaine 0.3% 27G Mid / Deep dermis

e.p.t.q. S500 ●●● HA 24mg/ml 25G, 27G Subcutaneous / Supraperiostal areas

e.p.t.q. S500lidocaine

●●● HA 24 mg/mlLidocaine 0.3% 25G, 27G Subcutaneous / Supraperiostal areas

e.p.t.q. S500for body

●●● HA 24mg/ml Body

• Product Name: Biomaterial for tissue repair• Indications: Temporary improvement of facial wrinkles• Product Classification: single-use sterile medical device• Package Information: Face: 1 Pre-filled syringe (1.0 mL) * 2 needles / Body: 3 Pre-filled 5ml syringes with 3.5cc / Box• Storage condition: 2⁰C - 25⁰C / Do not freeze or heat the product / Keep away from direct light

PDO PCL

Product Code 19G-060 18G-090 19G-060 18G-090

Thread Length 6cm 9cm 6cm 9cm

Cannular Size 19G 18G 19G 18G

No. of Units 64 96 64 96

USP 3-0 2-0 3-0 2-0

Biodegradation period 16~24 months 6~8 months

• Package Information: 8 sutures*5 packs / box

• Cannular Type: W / L type

Innovative MAS (Multi Anchoring System) 5 PACK / BOX

Contouring Thread

Dual action of innovative MAS (Multi Anchoring System) 40 EA / BOXDual action of innovative MAS (Multi Anchoring System) 40 EA / BOX

PDO

Contouring Thread

Co

nto

uri

ng

Th

read

PDO

Lift-up with epiticon Volume-up with e.p.t.q.

HIP

Before

Before

epiticonX

e.p.t.q.

epiticonX

e.p.t.q.

X