ISSN 0962-8436

volume 365

number 1544

pages 1149–1294

The population genetics of mutations: good, bad and indifferentPapers of a Theme issue compiled and edited by Laurence Loewe and William G. Hill

27 April 2010

volume 365 . number 1544 . pages 1149–1294

27 April 2010

The world’s longest running science journalFounded in 1660, the Royal Society is the independent scientific academy of the UK, dedicated to promotingexcellence in science

Registered Charity No 207043

rstb.royalsocietypublishing.orgPublished in Great Britain by the Royal Society, 6–9 Carlton House Terrace, London SW1Y 5AG

In this Issue

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The population genetics of mutations:good, bad and indifferentPapers of a Theme issue compiled and edited by Laurence Loewe and William G. Hill

PrefaceMutations and Brian Charlesworth 1151L. Loewe & W. G. Hill

IntroductionThe population genetics of mutations: good, bad and indifferent 1153L. Loewe & W. G. Hill

ArticlesMeasurements of spontaneous rates of mutations in the recent past and the near future 1169F. A. Kondrashov & A. S. Kondrashov

Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli 1177S. Trindade, L. Perfeito & I. Gordo

What can we learn about the distribution of fitness effects of new mutations from DNA sequence data? 1187P. D. Keightley & A. Eyre-Walker

The population genetics of beneficial mutations 1195H. A. Orr

Forces that influence the evolution of codon bias 1203P. M. Sharp, L. R. Emery & K. Zeng

What drives recombination hotspots to repeat DNA in humans? 1213G. McVean

Transposable elements in natural populations of Drosophila melanogaster 1219Y. C. G. Lee & C. H. Langley

Mutations and quantitative genetic variation: lessons from Drosophila 1229T. F. C. Mackay

On epistasis: why it is unimportant in polygenic directional selection 1241J. F. Crow

Genetic hitchhiking versus background selection: the controversy and its implications 1245W. Stephan

Beneficial mutations and the dynamics of adaptation in asexual populations 1255P. D. Sniegowski & P. J. Gerrish

The role of meiotic drive in hybrid male sterility 1265S. R. McDermott & M. A. F. Noor

Mutation and the evolution of ageing: from biometrics to system genetics 1273K. A. Hughes

Mutation and the evolution of recombination 1281N. H. Barton

See further with the Royal Society in 2010 – celebrate 350 years

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