the problem prototype hardware platform for acquiring the sacbct images completed
DESCRIPTION
X-Ray Tube. Camera Box. Small Animal Cone beam CT Class project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006. SYSTEM OVERVIEW The small animal cone beam CT (SACBCT) system is a component of a prototype image guided small animal radiation therapy research platform. - PowerPoint PPT PresentationTRANSCRIPT
THE PROBLEM
• Prototype hardware platform for acquiring the SACBCT images completed
• However, there is no software for image correction, dewarping and reconstruction for novel small-animal cone beam CT system
THE SOLUTION
Build Java software to simplify the operation of the platform• Image intensity correction• Characterize variation in X-ray attenuation• Reconstruction of 2D projection images into volumetric
representation using the Feldkamp algorithm
• Output volumetric rendering in standard DICOM format for future use.
• UI for display and manipulation of 2D and 3D images:
THE IMPACT• Currently, experimental image guided radiotherapy and
conformal beam therapy techniques are performed on human subjects
• The small animal radiotherapy research platform (SARRP) allows novel techniques to be validated and studied on the standard animal oncological models (Harvard OncoMouse and similar) in a convenient bench top environment
• This research is expected to speed the availability of novel therapies, and provide rigorous validation of procedures in pre-clinical trials
Engineering Research Center for Computer Integrated Surgical Systems and Technology
Figure 1: (a) Helical CT scan.
(b) Cone beam CT for human
(c) the system for the small animal cone beam CT
THE FUTURE• On-line, near real-time data acquisition and processing• Integrated calibration routines• Conversion to flat-panel detector with mechanical
shutter from direct-imaged phosphor system• In-situ imaging and image-guided conformal beam
therapy
PEOPLE INVOLVED• Mentors: Dr. John Wong, PhD, Dr. Todd McNutt, PhD
and Dr. Eric Ford, PhD (Department of Radiology oncology)
• Team Members: Owen Gray, Sungjun Kim and Pinak Pujari (Computer Science graduate students)
SUPPORTED BY:• NIH R01 project (Principle investigator Dr. John Wong,
Rad. Onc., JHMI),
(b)
SYSTEM OVERVIEW
The small animal cone beam CT (SACBCT) system is a component of a prototype image guided small animal radiation therapy research platform.
When completed, the system will provide a means of testing novel image guided radiation therapy techniques on standard laboratory oncological models (OncoMouse etc.) to characterize dose response of tumors in a preclinical laboratory setting.
LESSONS LEARNED
• Working in group is not easy. (schedule conflict and different technical background.)
• Satisfying customer’s needs not like just doing homework assignments.
Figure 2: Experimental lab set up
Figure 3: Screen Shots
Small Animal Cone beam CT Class project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006
10cm
3cmX-Ray Tube Camera Box
(a)
(c)