the

Recordv U. S. DEPARTMENT OF

HEALTH, EDUCATION, AND WELFAREFebruary 1, 1972Vol. XXIV, No. 3 NATIONAL INSTITUTES OF HEALTH

Show at CC Will Open• New Employee Program- For Sickle Cell Screening' A WRC-TV staff presentation,

including News 4 Washington colortelecasts, will open the ClinicalCenter's voluntary Sickle Cell

* screening program for NIH em-ployees.

The show will be held Wednes-day, Feb. 23, at 11:30 a.m., in theJack Masur Auditorium with si-

, multaneous relay to the 14thfloor assembly hall via the CC's

_j television system.Participants include WRC's Neil

••> Boggs as anchor man and re-porter Andrea McCombs as wellas NIH staff members.

. Baseball Stars Appear

Appearing in the telecasts are• Dock Ellis, one of the National

League's top pitchers who has thesickle trait, and the PittsburghPirates' outfielder, Willie Stargell,

« whose daughter is also a carrier.Following the telecasts, Mr.

• Boggs, Miss McCombs, and NIHmembers of the steering commit-

" tee for the CC Sickle Cell pro-gram will answer questions from

- the audience.This is the initial step in a

""• series of presentations, panel dis-cussions, and lectures to inform

' NIH employees about sickle cellanemia and its implications intheir lives.

» These educational sessions areprimarily designed to help em-

jn, ployees decide if they wish to betested and whether it would be

, more advantageous to participatein the NIH program or to seekthe test and counseling elsewhere.

Members Listed

Steering committee members.. are: Dr. George W. Shaffer, EHS,

chairman; Dr. Jerome Block, CC, associate director; Dr. M a k i o

Murayama, NIAMD, and Dr.Charles Olweny, NCI GuestWorker.

Also, Dr. Harvey R. Gralnickand Minna Feld, CC Clinical Path-ology Department; Dr. MargaretDunn, Shirley Fletcher, and JamesMoon, OPM, and Helen Auth,EHS.

Baby With Immune Defect Lives in IsolatorUnder Watchful Eyes of Medical Team

2 Scientists NominatedFor A. Flemming Award

NIH scientists Drs. Richard M.Asofsky and Jacqueline Whang-Peng are two of 20 semi-finalistsnominated for the FlemmingAward.

The Arthur S. Flemming an-

Little David, 3 months old when these photos were taken, naps peacefully inhis sterile environment living quarters. The adjoining isolator holds David'sessential supplies—including toys.—Photos by Texas Children's Hospital.

By Jerry GordonA 5-month-old baby suffering from a severe immunological defect

is living in a sterile plastic unit—an isolator—under the watchful eyesof a team of Baylor University Medical College doctors at the General

Clinical Research Center, TexasChildren's Hospital in Houston.

The basic concepts of the iso-lator that is being used to keepthe baby alive were developed ata germ-free animal resource inthe Lobund Laboratories of NotreDame University.

Both the animal resource andthe research center are supportedb y t h e Division of Research Re-sources.

David, the infant, is afflictedwith a rare case of lymphopenichypogammaglobulinemia — a de-ficiency of the defense mecha-nisms that help combat childhooddiseases.Detected Before Birth

The malady was detected beforebirth and the baby was deliveredunder totally sterile conditions bycesarean section at Houston's St.Luke Hospital in September.

He has remained in the spe-cially-designed germ-free isolatorever since while the Baylor phy-sicians are attempting to induceantibody production in his body.

Some degree of success hasbeen reported by pediatrician Dr.

(Continued on Page S)

Dr. MacLean to DeliverAnnual Mider LectureOn Wednesday, Feb. 9

Dr. Paul D. MacLean, chief ofthe Laboratory of Brain Evolu-tion and Behavior at the Na-tional Institute of Mental Health,Health Services and Mental HealthAdministration, will present thisyear's G. Burroughs Mider Lec-ture on Wednesday, Feb. 9, at 8:15p.m., in the Jack Masur Audito-rium, Clinical Center.

Dr. MacLean will speak on"Survival Mechanisms of the Tri-une Brain: Some Hopeful As-pects."

Man possesses "a remarkablelinkage of three brain types rad-ically different in structure andchemistry, which in an evolution-ary sense, are eons apart," ac-cording to Dr. MacLean.

Discussing his upcoming lec-ture, Dr. MacLean said, "I willfocus on our investigations ofthe two older type brains, anddiscuss relevance of the findingsin animals to forms of humanbehavior."

Dr. MacLean earned his bache-lor's and M.D. degrees at YaleUniversity.

His distinguished career in med-ical research, practice, and ped-agogy has brought him numerousawards and honors.

Among these are the SalmonMedal for Distinguished Research

(See DR. MACLEAN, Page 8)

Dr. Whang-Peng Dr. Asofsky

nual awards program, honoringoutstanding young men andwomen in the Federal Govern-ment, is principally sponsored bythe U.S. Jaycees.

Ten awards will be presented—five in scientific or technicalfields and five in administrative

(See FLEMMING NOMINEES, Page S)

Dr. MacLean will discuss the relevanceof his findings on animals as it relatesto human behavior forms.

Page 2 February 1, 1972 THE NIH RECORD

wlecordKathryn R. Knight Dies;Nursing Supervisor CitedFor Outstanding Service'

Published biweekly at Bethesda, Md., by the Publications and ReportsBranch, Office of Information, for the information of employees of theNational Institutes of Health, Department of Health, Education, andWelfare, and circulated by request to interested writers and to investi-gators in the field of biomedical and related research. The content isreprintable without permission. Pictures are available on request.The NIH Record reserves the right to make corrections, changes or dele-tions in submitted copy in conformity with the policies of the paper andthe Department of Health, Education, and Welfare.

NIH Record Office Bldg. 3 1 , Rm. 2B-03. Phone 49-62125

Editor Frances W. DavisAssistant Editor Fay LevieroStaff Writer Ed Driscoll

Staff Correspondents

ADA, Nelson Sparks; BHME/OD, Florence Foelak; CC, Ann Bain-bridge; DAHM, Laura Mae Kress; DBS, Faye Peterson; DCRT, JoanChase; DDH, Carolyn Niblett; DMI, Marian R. Fox; DN, Evelyn Laz-zari; DPHPE, Eleanor Wesolowski; DRG, Sue Meadows; DRR, JerryGordon; DRS, Robert Knickerbocker; FIC, Lois P. Meng; NCI, Eliza-beth Shollenberger; NEI, Julian Morris; NHLI, Bill Sanders; NIAID,Krin Larson; NIAMD, Katie Broberg; NICHD, Lloyd Blevins; NIDR,Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Warddell;NIMH, Daniel Rice; NINDS, Anne Tisiker; NLM, Roger Gilkeson.

NIH Television, RadioProgram Schedule

Radio

DISCUSSION: NIH

WGMS, AM—570—FM Stereo103.5—Friday, about 9:15 p.m.

February 4Dr. Edward A. Graykowski,

NIDRSubject: Oral Ulcerations

February 11Dr. Jack S. Cohen, DCRTSubject: How Proteins WorkInterview during intermission,

Library of Congress concerts.

Dr. Talbot, British Scholar,Will Speak at NLM Feb. 14

Dr. Charles W. Talbot of theWellcome Institute of the Historyof Medicine, London, England,will speak at the Feb. 14 meetingof the Washington Society forthe History of Medicine.

Dr. Talbot, a Research Fellow,will discuss Hospital Care of theSick in the Middle Ages, at 8p.m., in the Billings Auditorium,National Library of Medicine. Themeeting is open to visitors.

Dr. Talbot is also a member ofthe Department of History ofMedicine, University College, Uni-versity of London, and has pub-lished books on medieval subjects.

PANORAMA

Television(Ask the Doctor)

WTTG-TV, Channel 5, 12:30p.m.

February 3Dr. Harry R. Reiser, NHLISubject: Hypertension

February 8Dr. Ralph A. Frew, NIDRSubject: National Children's

Dental Health WeekFebruary 10

Dr. Harold R. Englander, NIDRSubject: National Children's

Dental Health Week

February 15Dr. Elizabeth Weisburger, NCISubject: Environment and Can-

cer

James Farmer, speaking in the CC'sJack Masur Auditorium on the lastday of commemorative events in honorof the late Dr. Martin Luther King'sbirthday, stressed Dr. King's selfless-ness and his dedication to the welfareof all people. Mr. Farmer also advo-cated participation in EEO programsas a fitting tribute to Dr. King.

Kathryn R. Knight

Kathryn R. Knight, a supervi-sory nurse at the Clinical Centersince 1951, died suddenly Jan. 12at her home, apparently after aheart attack.

Miss Knight, who served as as-sistant to the chief of the CCNursing Department, was respon-sible for the nursing activitiesthroughout the hospital duringthe evening hours.

She was also a panel memberof the Board of U.S. Civil ServiceExaminers.

She received repeated recogni-tion for her services.

"Miss Knight was one of themost responsible and conscien-tious people to hold that posi-tion," said Louise Anderson, chiefof the Nursing Department.

Lauded for Work

"Her death represents a per-sonal loss to us. . . . Miss Knighttook a great interest in everyemployee, often counseling thoseunder her supervision," she added.

Miss Knight, a native of Bowl-ing Green, Ohio, began her 40-year nursing career as a super-vising orthopedic nurse with theCrippled Children's Service of theOhio State Department of PublicWelfare.

She was subsequently employedas a public health nurse with theD.C. Health Department; assist-ant director of Nursing Services,Sinai Hospital, Baltimore, and di-rector of the School of Nursingand Nursing Service of the oldCentral Dispensary and EmergencyHospital, Washington, D.C.

Miss Knight's service extendedbeyond her nursing career. On Sun-days she played the organ forchapel services for CC patients,and was official organist for theEastern Star, of which she was amember.

A graduate of St. Vincent'sHospital School of Nursing in

Income Tax AssistanceGiven at 4 Locations

Assistance in computing incometaxes and tax information will begiven at the following locations:

Michael A. Steuer, Bldg. 31, IRm. 8A-19, Ext. 63013; Monday,1 to 5 p.m.; Wednesday, 8:30a.m. to 12:30 p.m., and Friday,8:30 a.m. to 5 p.m.

Michael A. Meehan, Bldg. 10,Rm. 1B-35, Ext. 65374; Tuesday,12:30 to 5 p.m.; Wednesday, 8:30a.m. to 5 p.m.; Thursday, 2 to5 p.m., and Friday, 12:30 to 5p.m.

Other Locations Listed

Anthony M. Rachal, III, Bldg.13, Rm. G-1315, Ext. 63046; Mon- -day, 8:30 a.m. to 12:30 p.m., andFriday, 8:30 a.m. to 5 p.m. Hewill be at the Westwood Bldg.,Rm. 335-A, Ext. 67119; Tuesday,12:30 to 3:30 p.m., and Wednes-day, 8:30 a.m. to 12:30 p.m.

A draft copy of the tax returns ,should be completed as far aspossible when requesting help.Telephone inquiries will be an-swered between 4 and 5 p.m.

If the W-2 Form has not beenissued, employees may refer to <their Earnings and Leave State-ment for the pay period endingDec. 11 to obtain the cumulativeamounts deducted for Federal andstate taxes.

Tax forms are available atabove locations and at the CreditUnion, Bldg. 31, Rm. 1A-08.

NCI Receives Award for ExhibitPrepared by Information Section

The National Cancer Institutewas recently awarded the SilverCertificate of Merit by the Na-tional Medical Association.

NOI received the award for an *exhibit titled "National CancerInstitute — Research and Related 'Programs," at the 76th annual ,meeting of the NMA dn Philadel-phia.

The prize-winning display wasprepared by the Publications,Visuals, and Reference Section, *Research Information Branch.

Birmingham, Ala., Miss Knightheld a B.S. degree in PublicHealth Nursing and an M.S. de-gree in Nursing Education fromCatholic University of America, •>where she majored in nursing ad-ministration.

She is survived by her mother,Laura Knight, of the home ad-dress, 10122 Tenbrook Drive, Sil-ver Spring, Md.

Contributions in her name maybe made to the Memorial Fund,National City Christian Church,14th Street at Thomas Circle, N.W.,Washington, D.C.

THE NIH RECORD February 1, 1972 Page 3

Program; Offers ChanceFor Advancement; TypingSkills Taught on Campus

Classes in the Clerk-TypistTraining Program are again be-ing offered at NIH for careerand career conditional emnloyeesin dead-end or limited-skill jobs.

Previous typing or clerical ex-perience is not required. The full-time program consists of 13weeks of classroom instructionsand 12 weeks of on-the-job train-ing.

Classes will be held from April3 through July 3. They will beconducted in Bldg. 35 by teachersfrom the Montgomery CountyAdult Education Program. Sub-jects include typing, English,math, writing, filing, and generaloffice procedures.

About 20 clerk typist traineeswill be accepted through the NIHMerit Promotion Plan. Employ-ees, including Wage Grade per-

1 sonnel, will be paid GS salariesequal to their current salaries.Salaries Explained

However, no salaries will behigher than GS-3, step 10. Anexception will be made for GS-4clerical employees who will con-tinue 'to receive their regularsalaries.

Personnel who pass the coursewill be assigned to clerk-typistpositions. Employees who do notmeet course requirements will re-turn to their original assign-ments or to another job withcomparable salary.

B/I/D personnel offices havethe application blanks — Form170. Send completed forms byFeb. 11, to Training and Em-ployee Development, OPM, Bldg.31, Room B2B-15, Tube StationDS-7. For further informationcall Ext. 65118.

Friends, Colleagues Honor Jane Stafford George Brandner RetiresA 'TL r* A i J l c • \KI M* ' F r o m Federal Service;

As The First Lady of Science Writing Served Here Since 1948

EHS Movie of the MonthStresses Food and Nutrition

The Employee Health Serv-ice will present "Three TimesA Day" as its Februarymovie. The 28-minute colorfilm emphasizes food andnutrition.

Information — do's anddon'ts—in the movie pointsout ways to avoid excessiveweight, high blood choles-terol, and coronary heartdisease.

Shopping tips and practicalday-to-day guides for goodnutrition are also given.

The movie will be shown inthe CC Jack Masur Audito-rium, Wednesday, Feb. 16, at11:30 a.m. and 12:15 p.m.,and in Westwood Building,Conference Room D, Thurs-day, Feb. 17, at 1:15 and2 p.m.

Miss Stafford enjoys the satire of the Ad Hoc Players, Hod Ogden (I), JohannesStuart, and Mr. Goldberg. "Stew" Hunter is hidden behind Mr. Ogden.

Jane Stafford, NIH assistant director of Information, was hailedas "the first lady of science writing" at a reception and dinner Jan. 11in celebration of her retirement.

Miss Stafford retired Dec. 31 after 15 years in the Office of In-formation, OD, and a total of 45years in science writing and sci-ence information activity.

Her party at the Officers' Club,National Naval Medical Center,was attended by more than 150friends and colleagues who gath-ered from several nearby States.

As a highlight of the evening,John Troan, editor of the Pitts-

woman president, and her contri-butions for recognition of theprofession.

Dr. G. Burroughs Mider, deputydirector of the National Libraryof Medicine, and former Directorof Laboratories and Clinics forNIH, reminisced about MissStafford's years as a reporter forScience Service, when she ofteninterviewed scientists.

He also recalled her contribu-tions to preparation of NIH re-ports to the Congress during thepast 15 years.

Donald Kirkman, Scripps-Ho-ward Newspapers' chief sciencewriter and present president ofthe National Association of Sci-ence Writers, presented Miss Staf-ford with an album of letters,photographs, and other memen-tos.

Storm Whaley, NIH AssociateDirector for Communications,presented Miss Stafford with theprincipal gift contributed by her

(Continued on Page 6)

Miss Stafford was the cover girl forthe Scripps-Howard News Science Serv-ice in May T951.

burgh Press, presented Miss Staf-ford with a citation for her con-tributions to science writing andpublic understanding of scienceon behalf of the Council for theAdvancement of Science Writing.

David Dietz of Cleveland, Ohio,science editor of Scripps-HowardNewspapers and a founder andfirst president of the NationalAssociation of Science Writing in1934, described the early years ofscience writing.

He traced the formation of theprofessional organization, ofwhich Miss Stafford was the first

George A. Brandner, NationalCancer Institute, retired lastlast month after 30 years ofFederal Service. Mr. Brandner waschief of the Research ContractsBranch.

He is a graduate of ColumbiaUniversity's American Instituteof Banking, and came to NIH in1948 as assistant administrativeofficer, National Institute of Ar-thritis and Metabolic Diseases.Prior to coming here, he wastraining and placement officer forMt. Alto Veterans' Hospital.

In 1955, he was appointed ad-ministrative officer, Cancer Chem-otherapy National Service Center.Later, he was named programmanager and operations officerin that program.

From 1963 to 1964 Mr. Brand-ner served as chief of NCI's Re-

Mr. Brandner assisted in developingNCI's Research Contract program.

search C o n t r a c t OperationsBranch. He then was named chief,Grants and Research ContractsOperations Branch, ExtramuralActivities. Last July that branchbecame the present NCI branch.

Mr. Brandner will join Univer-sities Associated for Researchand Education in Pathology Inc.as administrative officer.

Steuben candle holders and bowl areplaced on Miss Stafford's table.

Dr. George J. CosmidesReceives AAAS Award

Dr. George J. Cosmides recentlyreceived the 1971 DistinguishedScientist Award from the Phar-maceutical Sciences Section of theAmerican Association for theAdvancement of Science.

The award is given to prestigiousresearchers chosen by the officersof the AAAS.

Dr. Cosmides is coordinator inthe Pharmacology - ToxicologyProgram of the National Insti-tute of General Medical Sciences.

He gave the Distinguished Lec-ture, entitled "Human Variabilityand Safer, More Effective Phar-macotherapy," at the AAAS an-nual meeting in December.

Page 4 February 1, 1972 THE NIH RECORD

1973 NIH Budget Summary

Amounts inComponents ThousandsOD . $ 11.526DBSNCINHLINIDRNIAMDNINDSNIAIDNIGMSNICHDNEI . . . .NIEHS . . .PICBHMENLM . . .Research

Resources .Bldgs. and

Facilities ..Scientific

ActivitiesOverseas . .

Total

9,297430,000254,416

44,076158 394117,298111,907175,716126,696

37,20128,817

4,465536,65528,104

74,929

8,500

25,619

. . . $2,183,616

NIH Budget Request Exceeds $2.1 BillionFor FY 1973, Increase of $7.6 Million

On Jan. 24 the President submitted to Congress his Fiscal 1973 FederalBudget recommending a total of $2,183.6 million in new obligationalauthority to NIH. This includes $25.6 million for the appropriation,"Scientific Activities Overseas,"administered by the Office of Inter-national Health, which is includedwith NIH for presentation pur-poses.

The total figure represents anincrease of $7.6 million over com-parable figures for Fiscal 1972.Comparisons Made

Included in the $2,183.6 millionrequest for the NIH is $1,573.2million for research Institutesand Divisions (up $138.9 million),$536.6 million for the Bureau ofHealth Manpower Education($140.8 million below last year'srequest), and $28.1 million forthe National Library of Medicine(an increase of $4 million).

New obligational authority forresearch Institutes and Divisionsprovides $854.5 million for re-search grants (up $61.3 million),of which $607.6 million is for reg-ular grant programs, and $246.9million is for special researchgrant programs.

Another $483.4 million is pro-vided for direct operations (anincrease of $40.7 million), includ-ing $265.3 million (up $32.2 mil-lion) for research and develop-ment contracts, and $116.4 millionfor laboratory and clinical re-search ($2.6 million over 1972).

Changes Noted

In addition, the research I/Dtotal includes $137.3 million (anincrease of $2.9 million) fortraining grants, $49.1 million (up$1.1 million) for fellowships,and $49 million ($33 million"above 1972) for cancer construc-tion.

The $49 million will be usedfor construction of cancer re-search centers, etiology centers tostudy causative agents, and anout patient clinic, additional lab-oratories, and modernization ofcurrent facilities in the ClinicalCenter.

Allocations Described

Of the $536.6 million recom-mended for the Bureau of HealthManpower Education for Fiscal1973, $331.4 million is allocatedfor institutional support and di-rect student loans, scholarships,and traineeships in the medical,dental and related health profes-sions.

Funds also are provided in the$331.4 million for educationalgrants and contracts, direct oper-ations, computer technology andconstruction.

Other new monies in the overallBHME total include $12.7 millionfor dental health, nursing activi-

Investigators Take PartIn Meeting on Arthritis,NIAMD Study Discussed

Researchers from the NationalInstitute of Arthritis and Meta-bolic Diseases participated in ameeting of the American Rheuma-tism Association, held recently inSan Diego, Calif.

ARA is the professional sectionof the Arthritis Foundation, a na-tional voluntary agency.

The NIAMD researchers wereDr. John Decker, chief, Arthritisand Rheumatism Branch, ClinicalInvestigations, and two staffmembers, Dr. William E. Seamanand Dr. Alfred D. Steinberg.

ARA sessions focused on re-search that included chemothera-peutic and surgical approaches toarthritic diseases, and the role ofinfectious agents or imnranologicdisorders in rheumatoid arthritis.

Recent r e s e a r c h advancesthrough observation of laboratoryanimals were also discussed. In thepast, arthritis research was ham-pered by a lack of animal models.

ties account for $122.8 million,public health is allotted $21.6 mil-lion, and allied health, $35.6 mil-lion.

Funds — $28.1 million — recom-mended in the 1973 budget forthe National Library of Medicineinclude $19.6 million (an increaseof $2.4 million) for direct opera-tions, and $8.5 million for med-ical library assistance grants (up$1.6 million).

Major allocations in monies fordirect operations provide $3.1million for the Lister Hill Center,

NIH Toastmasters ElectJohn F. Belin President

The NIH Toastmasters Clubhas elected John F. Belin asits president for a semiannual termending June 30, 1972.

Ten memberships are availableto NIH employees who wish toimprove their speaking ability.

Meetings are held weekly onThursdays, 12 noon, Bldg. 10, inthe Cafeteria Dining Room 2.

For further information, callGeorge Abbott, Ext. 64402.

$8.7 million for Library Opera-tions, $2.7 million for the Na-tional Medical Audiovisual Cen-ter, and $1.6 million for Toxi-cology information.

Dr. Douglas A. Fenderson will head therecently created Office of Special Pro-grams, BHME. He was formerly chiefof Health Services Manpower, NationalCenter for Health Services Researchand Development, in the Health Serv-ices and Mental Health Administration.

NIH Visiting ScientistsProgram Participants1/1—Dr. Hortencia M. Rose-

mond, Panama, Laboratory ofBiology of Viruses. Sponsor: Dr.Bernard Moss, NIAID, Bldg. 5,Rm. 337.

1/1—Dr. Jytte Westergaard, tDenmark, Laboratory of Biologi-cal Structure. Sponsor: Dr. MarieU. Nylen, NIDR, Bldg. 30, Rm.211.

1/7—Dr. Snorri S. Thorgeirs-son, Iceland, Laboratory of Chem-ical Pharmacology. Sponsor: Dr.James R. Gillette, NHLI, Bldg.10, Rm. 7N119.

1/9—Dr. Nenad S. Markovic, "Yugoslavia, Leukemia Service.Sponsor: Dr. Edward S. Hender-son, NCI, Bldg. 10, Rm. 2B51.

1/10—Dr. Mariella Carta, Italy,Laboratory of Immunology. Spon- .sor: Dr. Rose G. Mage, NIAID,Bldg. 10, Rm. 11D10.

1/17—Dr. Ramesh C. Srivas-tava, India, Section on Molecular ..Chemistry. Sponsor: Dr. GuntherL. Eichhorn, NICHD, Gerontology 'Research Center, Baltimore, Md.

Members of the 50-man Clinical Center unit of ODA's Plant Engineering Branchdonated $266.50 to the Patient Emergency Fund through the Davis Plan thisyear. In the 7 years this unit has made group donations, members have con-tributed over $1,400 to the Fund. This year's donation, 11 percent more thanlast year's reveals their continued personal concern for CC patients.

Health Manpower Act ExplainedThrough BHME-Produced Film

The Bureau of Health Man-power Education has produced,"The Comprehensive Health Man-power Training Act of 1971," a40-minute film which explainsprovisions of new legislation re-garding grants and other finan-cial support available to healthprofessions schools.

Dr. Kenneth M. Endicott,BHME Director, and Dr. HarryW. Bruce, Director of the Divi-sion of (Physician and Health Pro-fessions Education, conduct thediscussion.

Prints are available on loanfrom the National Medical Audio-visual Center, Atlanta, Ga. 30333.

THE NIH RECORD February 1, 1972 Page 5

Eligible Candidates GivenGraduate School Training

According to the Office ofPersonnel Management, qualifiedcandidates with potential for as-suming high-level managementpositions may apply for 9 monthsof graduate university trainingunder the Education for PublicManagement Program.

Administered by the Civil Serv-ice Commission, the program pro-vides training at the followinguniversities: 'Cornell; U. of Indi-ana; Massachusetts Institute ofTechnology; Harvard; Princeton;Stanford; U. of Southern Cali-

. fornia; U. of Virginia, and theU. of Washington in Seattle.

May Indicate Preference

Candidates may state theirschool preference, and when pos-sible it will be followed. However,the C9C has the final responsi-

- bility for assigning schools.Each participant may select a

study program geared to hisneeds. Special seminars will bepart of the curriculum.

Eligibility requirements includeat least 5 years of Federal civiliancareer service; be in grades GS-11

> through GS-15; be '25 to 45 yearsof age; have a bachelor's degreeor comparable qualifications, andmeet university admissions re-quirements.

Participants receive tuition, fullsalary and benefits, and movingexpenses.

Applications must be receivedby the Training and EmployeeDevelopment Office no later thanFeb. 10. For further informationcontact that office: Bldg. 31,Room B2B-15, Tube Station DS-7,or call Ext. 62146.

BABY WITH IMMUNE DEFECT LIVES IN ISOLATOR

J• • • • • : . . , ' • • > . . . .

Jerry Whiddon and Michael Liftman,of STREET 70, performed for CC pa-tients on Jan. 21. The Patient Emer-gency Fund recently received a $50donation—part of the proceeds from amusical performance by the Rockvilletheatrical group.

David never lacks attention. He beams at Eileen Kneisler, nurse at the ClinicalResearch Center, and the nurse beams back at him. She holds him up "wearing"the rubber-gloved contrivance which protrudes into the compartment.

(Continued, from Page 1)John Montgomery and immunolo-gist Dr. Mary Ann South.

"His lymphocyte-making tissueis similar to that of an 8-week-old embryo," they said. "We thinkmaturation is the best hope. Inthe meantime, the isolator isbuying critical time for him."

David is the second son born tothe Texas couple whose malechildren have inherited the sex-linked recessive affliction. Thecouple's first son died in infancy.Parents Trained

David's parents have beentrained by the General ClinicalResearch Center personnel to op-erate the double-compartmentedisolator in which the child lives.Contact is made with the babyby use of rubber gloves whichprotrude into the germ-free plas-tic compartment.

The sterile environment consistsof a clear plastic 4- x 2-footcrib with a flexible canopy and asimilarly-sized connecting plasticsupply unit.

Food and clothing are steam-sterilized in a plastic cylinderthat fits into the supply unit, andthe air he breathes is filteredthrough four layers of glass wool.

Dr. George W. Clayton, programdirector of the Center, reportsthat the child, who appears to beperfectly normal from a psycho-logical and developmental stand-point, has been home twice. Hewas transported home completewith isolator at Thanksgivingand at Christmas.

"The specially-designed isolatorwill have to be expanded asDavid grows larger," Dr. Claytonexplained. "Of course, we at theCenter hope that he will be ableto leave his isolator by the ageof two."

FLEMMING NOMINEES(Continued from Page 1)

or executive fields—at a luncheonon Feb. 17.

Dr. Asofsky is assistant chiefof the Laboratory of MicrobialImmunity in the National Insti-tute of Allergy and InfectiousDiseases.

He also heads the LMI Experi-mental Pathology Section, andhas gained recognition for hisresearch on the control of im-munoglobulin synthesis.

As a member of the HumanTumor Cell Biology Branch ofthe National Cancer Institute, Dr.Whang-Peng has made numerouscontributions in the study of ey-togenic defects in disease states.

Her research has won her aninternational reputation.

Dr. Nelson K. RichtmyerRetires After 35 YearsIn Government Service

Dr. Nelson K. Richtmyer, asenior chemist at the NationalInstitute of Arthritis and Meta-bolic Diseases, retired recentlyafter 35 years of Federal service.

Dr. Richtmyer, a distinguishedresearcher in the field of carbo-hydrate chemistry, was withNIAMD's Laboratory of Chem-istry.

He received his B.A., M.A., andPh.D. degrees from Harvard Uni-versity, and has held researchpositions at his alma mater andthe University of Heidelberg inGermany, and also taught atBryn Mawr College.

In 1963 Dr. Richtmyer was pre-sented with the Claude S. HudsonAward for his outstanding con-tribution to chemistry in his field.The award, named for Dr. Hud-son who was chief of the NIH

All the articles, written by prestigiousscientists, in the special honor issueof "Carbohydrate Research" were ded-icated to Dr. Richtmyer.

Laboratory of Chemistry in 1929-1951, is given annually by theAmerican Chemical Society.

The NIAMD scientist workedclosely with Dr. Hudson when hewas chief of the laboratory. Dr.Richtmyer also edited, with thelate Dr. R. M. Hann, the two-volume edition of "The CollectedPaper of C. S. Hudson."

Dr. Richtmyer has held a num-ber of offices in the AmericanChemical Society.

Before he left the Institute afarewell party and gifts were pre-sented to him by colleagues.

J. Allan Lind, of NIAID's Rocky Moun-tain Laboratory, retired last monthafter more than 22 years with theLaboratory. At the time of his retire-ment, Mr. Lind was a fixed industrialequipment operator in the Plant Main-tenance and Operation Section.

'Reading Forum' Now AvailableReading Forum, a publication

issued by the National Institute ofNeurological Diseases and Stroke,focuses on children who do notlearn to read effectively.

The 256-page collection is freeupon postal request to: ReadingForum, I n f o r m a t i o n Office,NINDS, Bldg. 31, Room 8A-06.

Page 6 February 1, 1972 THE NIH RECORD

FRIENDS HONOR 'FIRST LADY OF SCIENCE WRITING'

• • • : • •

Star.d'.n.-'. 1-

Seated, 1~

Sot Present;

(Continued fi Page S)colleagues and friends, a pair ofSteuben candlesticks and matchingbowl.

Dr. Robert Q. Marston, Directorof NIH, presented her with a goldcharm, engraved with the NIHcolophon and her dates of service,for her charm bracelet.

Clifford P. Johnson, formerlyDirector of Information, present-ed her with a flag that was flownover the Capitol on her last dayof Federal employment.

Irving Goldberg, Director of

John Trocin presents Miss Stafford witha citation for her contributions toscience writing on behalf of the Coun-cil for the Advancement of ScienceWriting.

the Office of Information, NIH,gave her the final gift of theevening, a tape recorder and tapesof the entire evening's program.

The Ad Hoc Players, led byMr. Goldberg, presented a skitand sang several songs preparedespecially for the occasion, dur-ing the reception.

Colleagues at NIH and guestsat the party also signed a giant"greeting card" on which MissStafford was depicted as theStatue of Liberty, as a souvenirof the evening. There were ap-proximately 400 signatures onthe card.

Miss Stafford's career in sci-ence writing began on the maga-zine Hygaeia, predecessor of To-

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day's Health, published by theAmerican Medical Association, in1926.

After 2 years as an associateeditor there, she became a medi-cal science reporter for ScienceService, where she remained untiljoining NIH in 1956.

A native of Chicago, she re-ceived a B. A. degree from SmithCollege and worked as a labora-tory technician in an Evanston,111., hospital for 4 years beforetaking the Hygaeia assignment.

Miss Stafford was a winner ofthe George Westinghouse ScienceWriters Award and the HowardM. Blakeslee Award of the Amer-ican Heart Association.

Besides being a charter memberand president of the NationalAssociation of Science Writers,she has been a member of andpresident of the Women's Na-tional Press Club, and is a mem-ber of Theta Sigma Phi and theAmerican Public Health Associa-tion.

She was awarded the DHEWSuperior Service Honor Award in1971 in recognition of her con-tinuous activity over several yearsin the Office of Information andof having been Acting Directorof Information for 5 months in1970.

Dr. Marston, who presented Miss Staf-ford with a charm for her bracelet,praised her years of service with NIH.

Medical School, NINDSUndertake Joint StudiesOn Birthweight Factors

Studies at Johns Hopkins Uni-versity Medical School and Hos-pital, in conjunction with the Na-tional Institute of NeurologicalDiseases and Stroke's Collabora-tive Perinatal Research Project,suggest that birthweight may bea more important factor than ges-tational age when early inducedlabor or Cesarean section is con-sidered necessary.

Physicians have known formany years that some infants de-livered prematurely (early in thethird trimester of gestation) havebirthweights high enough tomatch those of full-term babies,and conversely, that some in-fants delivered at or near full-term, have low birthweights.

This, along with the more com-mon practice to deliver babieseven when duration of gestationis less than 36 weeks, has raisedquestions about the relationshipsbetween birthweight and gesta-tional age, and their role in caus-ing death and neurological im-pairment in the newborn.

Data Cited

Using data from the JohnsHopkins Collaborative Study, Drs.Irvin M. Cushner and E. DavidMellits have found that the riskof death among babies was great-est for those with low birthweight(1500 grams and under), regard-less of duration of gestation.

They also found risks were ac-ceptably low among infants intheir study with higher birth-weights (1500 grams and over)regardless of pregnancy duration.

Even in later stages of preg-nancy (igestatlonal ages of 34weeks and more), risks of deathand abnormality were adverselyaffected by low birthweight.

Other Factors Involved

Survival alone, however, maynot be the only consideration in-volved in the decision of whetheror not to deliver an infant.

Neurological exams of infantsin this study at one year of agerevealed that risk of abnormalfindings was greater among surviv-ing infants who weighed 1500grams or less at birth, irrespectiveof gestational age.

According to the investigators,however, the incidence of non-normal findings in infants weigh-ing under 2500 grams, even whendelivered closer to term, wouldjustify concern if early deliveryis considered.

The scientists caution that itmust remain the goal of everyobstetrician to maintain preg-nancy beyond the 35th weekwhenever possible.

Kinoshita Named Chief,Lab of Vision Research

Dr. Jin N. Kinoshita has beenappointed chief of the Laboratoryof Vision Research of the Na-tional Eye Institute.

Dr. Kinoshita will direct theInstitute's laboratory researchprogram to develop basic knowl-edge required for solving impor-tant problems related to eye dis-ease and blindness.

A distinguished scientist andan internationally recognized au-thority on the biochemistry ofthe eye, he was formerly profes-sor of Biochemical Ophthalmol-ogy at Harvard Medical School.

Dr. Kinoshita graduated fromBard College, then a part of Co-lumbia University, and receivedhis Ph.D. from Harvard in 1952.He also holds an honorary Sc.D.from Bard College.

'He became an instructor inBiological Chemistry at the Howe

Dr. Kinoshita has published papers onthe metabolism of the lens and otherocular tissues, and the chemical me-chanisms involved with the onset ofcataracts.

Laboratory and the Departmentof Biological Chemistry at Har-vard Medical School.

In 1956 Dr. Kinoshita was givena simultaneous appointment asassociate in Biological Chemistryat Harvard and biochemist withthe Massachusetts Eye and EarInfirmary.

He became assistant professorin Biological Chemistry at Har-vard in 1957 and in 1964 wasnamed associate professor in Bio-chemical Ophthalmology. A fullprofessorship was conferred ear-lier this year.

Dr. Kinoshita was the recipientof the 'Friewald Memorial Awardof the Association for Researchin Vision and Ophthalmology in1965 and shared in the Researchto Prevent Blindness Board ofTrustees Award in 1969.

He was a member of the VisualSciences Study Section, NIH,from 1965 to 1969, and served onNEI's Board of 'Scientific Coun-selors until his appointment.

THE NIH RECORD February 1, 1972 Page 7

Prevention Is Best Answer to Dental Disease

HAPPINESSis a

Healthy MouthNATIONAL CHILDREN'SDENTAL HEALTH WEEK

At some time in their lives, 98 percent of all Americans sufferfrom tooth decay, and 90 percent of adults have some degree ofperiodontal disease—prevention is the only answer.

During National Children's Dental Health Week, Feb. 6-12, theNational Institute of Dental Research emphasizes that the bestway to keep teeth and gums healthy is to clean them thoroughlydaily, keep sweets to a minimum, and have regular dental checkups.

Dr. H. Temin to Receive Bertner Award;Dr. Rauscher to Open Viral Symposium

The 1972 Bertner Foundation Award for outstanding achievementsin cancer research will be given to Dr. Howard M. Temin of the Uni-versity of Wisconsin on March 8 in Houston. Dr. Temin is a grantee

-Research Contracting Activities ChangeDesigned to Meet Expanding NIH Needs

The reorganization of research contracting activities at NIH—withauthority delegated to seven Institutes—is now1 operational.

This change was completed last December when decentralized researchcontracting offices were estab-lished in these Institutes.

In addition to the Bureau ofHealth Manpower Education andthe National Library of Medi-

contracting officer will serve asthe agent of the Government onall contractual matters.

He will collaborate with scien-cine, which retain their contract- tific program officials during alling officer authority, the seven stages of the research contractingInstitutes delegated such author- process, from planning individuality and responsibilities as a re- procurements to closing out thesuit of the reorganization are:

National Cancer Institute, Na-tional Heart and Lung Institute,National Institute of Allergy andInfectious Diseases, and NationalInstitute of Arthritis and Meta-bolic Diseases.

System Evaluated

Also, National Institute ofChild Health and Human Devel-opment, National Institute of Den-

contract.A central research contracting

staff has been retained in OCGto serve those institutes, divi-sions, and offices not delegatedcontracting authority.

Contract property managementservices will continue to be pro-vided centrally by the Office ofAdministrative Services, ODA.

Financial advisory and otherservices—such as the negotiation

tal Research, and the National In- of basic agreements for contractsstitute of Neurological Diseasesand Stroke.

Just one year ago, when AlexSmallberg was appointed Direc-tor of the then newly-createdOffice of Contracts and Grants,he was charged with the respon-sibility of evaluating NIH's ex-panding research contracting op-erations.

Mr. Smallberg was also direct-ed to recommend an organizationwhich would best serve NIH's

with educational institutions—will be provided by OCG.

The Office of Contracts andGrants will continue to operateas NIH's central policy planningand evaluation staff office forresearch contracting and willmaintain a continuing surveil-lance over all research contract-ing operations.

In addition to providing advi-sory services and assistance, OCGwill continue to serve as the NIH

tracting.

of the National Cancer Institute.The award will be presented by

the University of Texas M.D.Anderson Hospital and TumorInstitute at its 25th Annual Sym-posium on Fund-amental CancerResearch, "Molec-ular Studies inViral Neoplasia."

Dr. E. W. Bert-ner, for whom theaward is named,was first actingdirector of the

program needs and assure sound focal point on all negotiatedresearch and development con- contract policy matters and all

research contracting actions re-This decentralized organization quiring approval by the NIH Di-

is designed to improve NIH con- rector or the HEW Secretary.tract management and strengthenits collaborative research pro- It cost 15.5 cents per mile tograms by promoting closer work- drive 10,000 miles per year—oneing relationships between scien- cent more than 2 years ago—ac-tific, program, and contracting cording to an American Automo-personnel. bile Association s t u d y . — D.C.

Under this team concept, the Traffic Safety Reporter.

Dr. RauscherM.D. AndersonHospital.

Several hundred scientists andphysicians are expected to attendthe meeting at the Shamrock-

Dr. Temin first distinguishedhimself as a researcher during hisgraduate school days. He wasamong the first scientists to ob-serve requirements for participa-tion of DNA in the multiplica-tion of RNA in Rous sarcomavirus.

It was his subsequent investi-gation of the Rous sarcoma virusat McArdle Laboratory that ledhim to propose that the geneticinformation of an RNA cancervirus must be transcribed intoDNA, or provirus, to cause can-cer.

While seeking mechanisms forstudying the provirus, he made a

Hilton Hotel from March 8-10. number of important contribu-Speakers from more than 25 na-tional and international institu-tions will present papers.

tions to other areas of viral on-cology.

Other NCI scientists partici-Dr. Frank J. Rauscher, Jr., sci- pating in the conference are Drs.

entific director for Etiology, NCI, Albert J. Dalton and Ursulawill deliver the keynote address. Heine, Viral Oncology; Dr. Tim-

The meeting is co-sponsored othy E. O'Connor, Viral Biologyby the University of Texas Grad- Branch, and Dr. Robert C. Gallo,uate School of Biomedical Scien-ces, Division of Continuing Edu-c a t i o n ; the American CancerSociety, Texas Division, and theNational Cancer Institute.

Dr. Temin currently serves ashead of the viral oncology lab-oratory of the McArdle MemorialLaboratory at the University ofWisconsin.

'Provirus' Proposed

In 1964 Dr. Temin proposedthat the genetic information of anRNA cancer virus must be trans-scribed into DNA, or "provirus."The double-stranded DNA thencould be integrated into the nor-mal cell's DNA to cause cancer.

The hypothesis was proven fac-tual in 1970 when Dr. Temin andDr. Satoshi Mizutani of McArdlediscovered the facilitating enzyme,reverse transcriptase, also calledRNA-dependent DNA polymerase.

The enzyme serves as a catalystfor RNA to manufacture DNAand thus reverse the normal flowof genetic information.

Discovery of reverse transcrip-tase enabled scientists to under-stand how a possible provirus maybe formed.

Hypothesis Confirmed

At approximately the sametime, Dr. David Baltimore of theMassachusetts Institute of Tech-nology, confirmed Dr. Temin'shypothesis independently by dis-covering the enzyme in two dif-ferent RNA tumor viruses.

Both researchers announcedtheir findings in a June 1970 issueof Nature.

HumanBranch.

Tumor Cell Biology

Dr. Temin has a research career de-velopment award and receives con-tract and grant support from NCI.

D. C. Dietetic Ass'n HonorsEdith A. Jones for Leadership

Edith A. Jones was recentlyawarded a plaque by the D.C. Di-etetic Association in recognitionof her "outstanding contributionto the profession of dietetics, in-spiring leadership, and years ofdistinguished service. . ."

Miss Jones has been chief ofthe Clinical Center Nutrition De-partment since 1953.

Three months ago, she receivedthe Marjorie Hulsizer Cop herAward, the highest honor givenby the American Dietetic Asso-ciation.

Page 8 February 1, 1972 THE NIH RECORD

Population Experts MeetWith Gov't ScientistsTo Discuss 5-Year Goals

A daylong briefing was held atthe Pogarty International Center,Stone House, on Jan. 17 forleaders of organizations con-cerned with population problemsand research.

The meeting was co-chaired byDr. Robert Q. Marston, NIH Di-rector, and former Senator Jo-seph Tydings, now also co-chair-man of the Coalition for a Na-tional Population Policy.

Some 20 invited participantsdiscussed the needs of populationresearch, the urgency of popula-tion problems, and the NIH re-search program with NICHD sci-entists and Dr. Louis Hellman,HEW Deputy Assistant Secretaryfor Population Affairs.

This meeting was an attemptto establish closer communicationand sensitivity to issues betweenNIH research administrators andorganization leaders.

Discussion focused on the 5-year goals for population re-search set by the Department—particularly NICHD's programgoals, including its intramuralresearch and the Center for Popu-lation Research.

In response to participants'questions, budgetary and organi-zational issues were probed atsome length.

Attending the conference wereprominent representatives fromthe World Bank, Robert S. Mc-Namara; the University of Cali-fornia, Dr. Philip R. Lee; the Na-tional Science Foundation, Dr.William McElroy, and HEW, Dr.Roger Egeberg.

, Other leading conferees werefrom the Swedish InternationalDevelopment Authority, the UNFund for Population Activities,the Ford and Rockefeller Foun-dations, the Commission on Pop-ulation Growth and the Ameri-can Future, Planned Parenthood-World Population, and the Popu-lation Crisis Committee.

NEI Eye Bank Established to FacilitateCorneal Transplants and Tissue Typing

Visitors' Spaces Reserved;Off Limits for Employees

NIH employees continue toreceive tickets for parkingnew cars bearing dealers'temporary t a g s (paper),rental vehicles, and borrowedvehicles in the spaces re-served for visitors.

Employees are never en-titled to park in visitors'spaces.

By calling the car dealersor rental agencies, an NIHtraffic officer can determinewhen an employee is using anew or rented car.

A corneal transplant which was rejected 6 months after surgery is picturedat left. Another transplant was performed, and the eye is clear (right) 4months following surgery. The success of the second graft is probably due tothe use of finer suture material and the operating microscope.

The National Eye Institute has established an eye bank at theClinical Center to facilitate the collection, classification, and storage oftissue for its clinical research projects.

The new eye bank will provide tissue for studies aimed at extendingthe benefits of corneal transplan-tation to a greater number ofpatients with corneal disease aswell as for other research whencorneas are not suitable for graft-ing.

NEI eye bank donors will beCC patients who have agreed toallow their eyes to be used forresearch, and outpatients followedon a continuing basis who haveoffered to pledge their eyes.Kertitoplasty Successful

NIH employees who wish topledge their eyes are urged tomake arrangements with otherhospital-affiliated eye banks inthe Washington metropolitan area.

Corneal grafting or keratop-lasty is the most successful of alltransplant procedures. In someseries, the success rate of kera-toplasty has been in excess of 90percent.

The reason for this success, inpart, is the development and per-fection over a long period of timeof surgical techniques and medicaltherapy which has establishedkeratoplasty as a standard oph-thalmic procedure.

Ophthalmologists have alsobenefited from the "privileged"nature of the cornea itself. Thenormal cornea has no blood ves-sels to allow the formation ofcirculating antibodies and possi-ble rejection of a corneal graft.

In many corneal diseases, suchas the hereditary corneal dystro-phies, there is no vascularizationof the cornea. It is for such con-ditions that high success rateshave been reported.

Grafting has been less success-ful in other diseases involvingextensive infiltration of vesselsinto the cornea.

In recent years, the operatingmicroscope — permitting the use

proved the prognosis for keratop-lasty in vascularized corneal dis-ease. But scientists would like toattain an even greater successrate.

During the past 4 years theimprovement in organ transplan-tation generally has been partial-ly attributed to the advent ofleukocyte typing. Through anti-genic typing of leukocytes, donorand recipient can be chosen to beantigenically similar.

The NEI Clinical Branch isconducting a study to determinewhether tissue typing and subse-quent donor matching can sig-nificantly improve the outcome ofkeratoplasty in vascularized cor-neas.NCI Scientists Assist

In this work, the NEI will col-laborate with scientists of theNational Cancer Institute, whoare widely recognized for pio-neering work in tissue typing.

At the present time, severaltransplantation centers are nowusing computers for the rapidmatching of prospective donorsand recipients following leuko-cyte typing.

Eyes from these donors areeither not used or are sent tolocal eye banks for random dis-tribution. This study may deter-mine whether tissue matchinghas any beneficial effect in kera-toplasty.

If the proper matching ofdonor and recipient does decreasethe incidence of homograft reac-tion often encountered in treatingvascularized corneas, many pa-tients who were previously notconsidered for keratoplasty couldbe benefited.

DR. MACLEAN(Continued from Page 1)

in Psychiatry, the Award forDistinguished Research from theAssociation for Research in Nerv-ous and Mental Disease, TheClarence Hincks Lectureship atQueen's University of Ontario,and the DHEW Superior ServiceAward.

Last year at this time, Dr. Mac-Lean received a special awardfrom the American Psychopatho-logical Association in recognitionof his scientific contribution tothe field of brain function andsexual behavior.

The Mider Lectureship, estab-lished in 1968, is awarded an-nually by the Director of NIH toa scientist who has contributedsignificantly to the biomedicalresearch eminence of NIH.

Dr. G. Burroughs Mider, forwhom the lectureship is named,was the first NIH Director ofLaboratories and Clinics. For 8years he guided NIH researchthrough a crucial period of de-velopment.

At present Dr. Mider is deputydirector of the National Libraryof Medicine.

Previous Mider Lecturers wereDrs. Roscoe O. Brady, Gordon M.Tomkins, and Lloyd W. Law.

Alexander Davis has been appointedmanager of the NIH Laundry and DryCleaning Section, Clinical Center Ad-ministrative Branch. Mr. Davis, whois an NIH EEO Counselor, was formerlyassistant chief of the Operations Sec-tion, CC Environmental Sanitation Con-trol Department.

of finer suture material which in-cites a minimal inflammatory re-sponse — has considerably im-

Remember when the teen-agedrug problem was finding onethat worked on acne.—ChangingTimes.

Dr. R. Doyle Named to AdvisoryCouncil of Research Resources

Dr. Richard E. Doyle, Directorof the Department of LaboratoryAnimal Medicine of the Univer-sity of Missouri-Columbia, hasbeen named to the National Ad-visory Research Resources Coun-cil.

Dr. Doyle's particular researchinterests have been in laboratoryanimal medicine, metabolic dis-eases, and animal models.