the university of sydneypage 1 translational research closing the gap between practice and research...
TRANSCRIPT
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The University of Sydney Page 1
Translational Research
Closing the Gap Between Practice and
Research
Professor Tim ShawDirector Research in Implementation Science and eHealth (RISe)Faculty, Health Sciences
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What is Translational Research?
2
Applied research
Basic research
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Why Translational Research?
• Consistent evidence of failure to translate research findings into clinical practice
• 30-40% patients do not get treatments of proven effectiveness
• 20–25% patients get care that is not needed or potentially harmful
(Runciman 2012; Grimshaw 2012; Schuster, McGlynn, Brook, 1998; Grol 2001)
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Clinical & Translational Research: Valleys of Death
Basic Biomedical and HSR Research
Clinical Science& Knowledge
Clinical Practice& Health Decision
Making
Translational Continuum – 17 years
Valley 1 Valley 2
Copyright University of Pittsburgh 2006Reis et al. Clin Transl Sci 2008
14% enter into standard clinical practice; 1% lead to important health impacts
Thanks to Eva Grunfeld
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Translation
Discovery Trials
Implementation
Improved Patient Outcomes
T1 T2
T3
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Purposeful intent around an identified issue/priority
What’s so special?
Isn’t that what we have all being doing anyway?
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Barriers
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SilosAcadem
ia
Hosp
itals
Discip
lines
Geog
rap
hy
QI
Capacity and understanding
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Eg TimelinesLanguageEnd points
MethodologiesRewards
Different planets?Academia/IS QI/Practice
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Lack of access to data
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Enablers
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Building capacity
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New Partnerships and FundingAdvanced Health Research and Translation Centres
Translational Cancer Research Centres
Academic Health Units
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A systematic approach to identifying and closing evidence-practice gaps
Longitudinal Programs
Tim Shaw, Nicole Rankin, Sarah York, Phyllis Butow, Jane Phillips, Kate White, Jane Young, Puma Sundaresan, Sally Pearson, John Symes
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Engaging MDTs in Translational Research
High Performing Tumour Program
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Paul Harnett, Lynleigh Evans, Henry Pleass, Guy Eslick, Arthur Richardson, Kim Hill, Kylie Museth, Anna Janssen, Tracy Robinson, Tim Shaw
High Performing Tumour Program
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Impact on clinical practice
+Impact on
professional development
+Impact on quality
improvement+
Generation of research questions
WS-LHD staff, Tim Shaw, Paul Harnett, Anna Janssen, Kylie Museth
Data Innovation Lab
High Performing Tumour Program
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Disruptive technology
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