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TheNational BIO-ECONOMY STRATEGY Dr Maneshree Jugmohan-Naidu D: Biotechnology

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2 Content 1)Definition and Aims of the strategy 2)Timeline 3)Context 4)challenges/opportunities 5)Bio-economy Strategic Objectives 6)Defining progress

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Bioeconomy Strategy 2013 "Bioeconomy" refers to activities that make use of bio-innovations, based on biological sources, materials and processes to generate sustainable economic, social and environmental development.

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Aims of the Bio-economy Strategy: Provides an economic engine for the new economy which will in turn provide a basis for future growth. Science-based "biosolutions" can be used to, for instance manufacture high-value protein products such as biopharmaceuticals and vaccines; produce biofuels; improve and adapt crops; remedy industrial and municipal waste; reduce production costs; reduce environmental impacts; improve improve the global competitiveness in the health, agriculture and industrial sector the quality of products; improve the performance of a range of economic sectors. A key objective is incorporating market pull into innovation activities Allows SA to respond more directly to global challenges such as the disease burden, food security, competitive industry, climate change and energy requirements as well as to maximise local beneficiation, improved quality of life and economic growth.

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Linked to other policies

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Timeline 6 Instruments: BRICs; NBN; PUB 2003 Merge into TIA 2009 2009 Outputs: 14 platforms established 73 projects funded Investment into 31 companies 221 products & 142 services 940 jobs 439 bursaries/indirect study support R247 mill leveraged (on R1 bill) Bio-economy Strategy development 2009-2013 Functioning NSI 2020 Bio- economy 5% of GDP 2050 Incorporation of learnings Nat Biotech Strategy 2001

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Basic AppliedTech Develop Commercial Publications/new knowledge/HCDPatents/new knowledge products Universities Science Councils Industry Biotech Landscape Value Chain Performers Funding Agencies Outputs NRF Service Platforms TIA/DSTIDC Centres of Competence/Platforms CoE NIPMO SARChI Where to Next: Strategy to strengthen the Bioeconomy.

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StrengthsWeaknesses Government commitment to The Bio-economy through its policies/strategies and funding Mega biodiversity Strong academic environment Excellent infrastructure Extensive Indigenous Knowledge Stable political environment and growing economy Emerging small companies Fragmented NSI - Researchers do not work together to conceptualise bigger projects which take into the value chain pipeline Innovation culture Public Awareness Water scarce country Extended times for regulatory approval Lack of skilled, qualified and experienced personnel Intellectual property management Entrepreneurial culture at universities and public research institutions underdeveloped Small biotechnology companies are not self sustainable, relying on Government funding. OpportunitiesThreats Private sector involvement in the implementation of Government policies/strategies Private sector willingness to train postgraduate students in Bio-entrepreneurship International investment Emerging venture capitalists Other Governments Departments willing to be involved in the development of the Bio-economy Loss of skilled, qualified and experienced human resources to othercountries Climate Change Aging skills SWOT Analysis SA NSI

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9 o Portfolio Analysis Findings: o Investments at HEIs & SCs: o Disruptive innovation. o Dont advance to market. o Companies: o Incremental innovation o IP based companies succeed vs. non-IP based. CONTEXT: Key features of SA Bio-economys NSI

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10 Challenges/opportunities Large but under-employed rural communities High burden of disease, excellence in R&D, but under- investment in innovation opportunities Increasing global food quality standards Under-utilised but substantial - livestock populations Need for continual improvement of commercially-relevant plants & animals Need to revitalise certain labour-intensive industries to maintain global competitiveness eg. sugar; forestry Carbon footprint / green economy Commercialise& mainstream IKS biodiversity products Climate Change

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11 Manage NSI according to industry sectors, and incorporate value chain approach Three thematic chapters: Agriculture Health Industry & Environment Bio-economy Approach

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Bio-economy: Agriculture Ensure food security, enhance nutrition and improve health and enable job creation through expansion and intensification of sustainable agricultural production and processing. Strategic projects Crop/livestock improvement both for biotic and physical stresses associated with climate change (including indigenous crops) Agroprocessing initiatives An integrated food nutrition research programme Animal vaccine capabilities Energy-crop initiatives Biocontrol and biofertilisers Aquaculture Soil conservation Water resource management Build high-value skills and capacities to enable agro-innovation Co-funding initiatives for innovation

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Bioeconomy: Health Sector Support and strengthen the country's local RDI capabilities to manufacture APIs, vaccines, biopharmaceuticals, diagnostics and medical devices to address the disease burden while ensuring security of supply of essential therapeutics and prophylactics. Strategic projects Develop improved therapeutics and drug delivery systems to address priority diseases including African Traditional Medicines Develop new and improved vaccines and biologics Develop improved diagnostics Develop improved medical devices Build clinical research and development capabilities Establish pharmaceutical manufacturing

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Bio-economy: Industry and Environment Support research, development and innovation in biological processes for the production of goods and services, while enhancing water and waste-management practices to support green economy. Strategic projects Strategic industrial biotechnology programmes Strengthen and develop bioprospecting capacity and capabilities Strengthen local bioprocessing capabilities Develop integrated biorefineries from bio-based feedstocks Strengthen wastewater research, development and innovation Strengthen waste research, development and innovation Synergies with enabling and emerging technologies. Establish an advisory committee for industrial bio-economy

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Industrial applications Sustainable Environmental Management Bio-based chemicals Bio-materialsBio-energyWaterWaste Bulk and speciality chemicals Biocatalysts Biocontrol products Additives Biocomposites Biopolymers Biodiesel Bioethanol Biobutanol Biogas Bioremediation of domestic and industrial wastewater Bioleaching Biometallurgy Biosorption Enabling technologies Biocatalysis 15 Industrial bio-economy

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SERVICES REGULATION Skills & Human Capital Innovate (Develop IP) Applied Research (Current Skills) BioDesign (Future Skills) Commercialise (Exploit IP) Commercial products and services INCUBATION (Facilities; business &marketing skills) INCUBATION (Facilities; business &marketing skills) PILOT SCALE PRODUCTION (bio-processing; bio-fermentation; bio-pharming) PILOT SCALE PRODUCTION (bio-processing; bio-fermentation; bio-pharming) TECHNOLOGY SERVICES (Genomics; Proteomics; Metabolomics; Metagenomics; Bioinformatics; etc) TECHNOLOGY SERVICES (Genomics; Proteomics; Metabolomics; Metagenomics; Bioinformatics; etc) REGULATORY COMPLIANCE (BiosafetySA; clinical trialing; preclinical platform) IP PROTECTION (NIPMO) IP PROTECTION (NIPMO) BIO-REPOSITORY (Human;Animal; Plant; Microbes) BIO-REPOSITORY (Human;Animal; Plant; Microbes) Research Ethics Human health products (MCC); Food products (Codex); GMO products (GMO Act); Biocontrol (Act 36) etc Biodiversity Regulations (access & benefit sharing) Biodiversity Regulations (access & benefit sharing) MTAs/ Genomic Sovereignty Coordinating Committees Industry Government The Market

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Role of DST Key strategic objectives Coordinate stakeholders and role players.- Promote active participation of ALL stakeholders is key towards successful implementation, performance objectives and milestones hence the coordination committees Coordination of projects across value chain (networking of, & value-addition to, projects) Orchestration of RDI innovators (incl. Technology Platforms; Team SA) Alignment of RD&I with industry and govt. needs Develop strategic innovation competencies. Development of the full value chain from concept to product. Bioinformatics, functional genomics, structural biology, synthetic biology and systems biology. Technology service platforms. Pilot-scale infrastructure. Incubation facilities. Financing. Human capital development capital resources not just financially but also multidisciplinary expertise Instruments to address specific knowledge needs. Knowledge management to develop a bioportal..

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Role of DST Key strategic objectives, contd. Develop strategic innovation programmes to address strategic gaps or opportunities for the country Identify and drive RD&I in long-term programmes which address National priorities HIV / AIDS [existing initiatives: DST/MRC - SHIP; SHARP], TB [DST/MRC SHIP; SATRI] Ongoing crop/animal improvement [ARC; TIA] Mainstreaming indigenous products and agricultural goods [IKS; ARC; CSIR; TIA] Strengthening Industry (revitalisation with alternative, competitive products & processes based on biotechnologies) [Eucalyptus Forestry; Sugarcane Industry; Waste treatment; Biocatalysis; TIA & CSIR] 18

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19 BioeconomyHCDR&DCommercial- isation Coordination Bioeconomy contribution to GDP Student outputs per year No. of publications and citations in high- impact journals per capita. No. of products and services No. of collaborative research partnerships Technology balance of payment of bio- innovation outputs. Throughput of non- academic skills training (incl. entrepreneurialism) Cumulative no. of bio- patents / plant breeders rights No. of start up companies No of companies reaching break even No. of collaborativeproduc t development partnerships No.of bio-innovation firms, including dedicated bio- innovation firms by sector Size of bio- workforce as percentage of S&T workforce. No.of regulatory approvals for locally produced health/agricultural products. No. multinational corporations in bio- economy sectors locating R & D facilities locally No. of funding partnerships No. of regulatory approvals for locally produced health/agricultural products. Leveraging international resources No. of projects progressing between funding institutions Indicators (to be informed by study)

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20 Thank you! Maneshree Jugmohan-Naidu @dst.gov.za