there are three scholarships for pre-medical students that are available for the 2010- 2011 academic...
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There are three scholarships for pre-medical students that are available for the 2010-2011 academic year. These are:
Whatcom County Medical Society Scholarship: one $500 award Dr. Ralph & Mrs. Eleanor Rinne Pre-Medical Scholarship: two $1500 awards
If you would like to apply, please visit
http://www.careers.wwu.edu/prehealth_financialaid.shtml
for a statement of eligibility and for application details.
Or, you may stop by Old Main 380 or Old Main 280 to pick up an application. Completed applications are due in Old Main 380 (Academic Advising Center) by Monday, May 3,
2010.
Figure 6-1 part 4
Protein Data Bank Workshop
pdb Rasmol
Do the protein explorer tour!!!!!
http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/qtour.htm
Chapter 6 Opener
Figure 6-4
Figure 6-5
Figure 6-6
Figure 6-7
Figure 6-8
Figure 6-9
Figure 6-9a
Figure 6-9b
Figure 6-10
Other Properties of Amino Acids
• Stereochemistry (all biosynthetic proteins made up of L-isomer)
• Hydropathy (partitioning between polar and nonpolar solvents as indicator of polarity) (see Table 6-2 in VVP p 150)
these two properties are major determinants of peptide conformation
Table 6-1
Figure 6-12
Figure 6-15 Keratin: a coiled coil
Figure 6-16 Higher order keratin structure
Globular Protein 3o Structure
2o structural elements (helices, sheets, turns…) pack together to give a folded protein or subunit. This so-called “tertiary” structure is stabilized by non-covalent interactions, the hydrophobic effect and disulfides. Within the 3o structure are “motifs” and “domains”.
The 3o structure can be derived from one or more domains.
Figure 6-20b Protein crystals: flavodoxin
Figure 6-20e Protein crystals: lamprey hemoglobin
Figure 6-21
Figure 6-27 cytochrome c: hydrophillic residues and hydrophobic residues
Figure 6-33 Hemoglobin
Table 6-3
Figure 6-35 Bovine chymotrypsin
Figure 6-38 Molecular dynamics of Mb
Page 159
Figure 6-39
Figure 6-40
Figure 6-41
Many conformational states
Fewerconformational states
A “single”conformational state Low energy
High energy
(Fig 6-38)
Many conformational states
Fewerconformational states
A “single”conformational state
See VVPFig 6-37 p153
“Ideal”“Real” ?See VVP
Fig 6-38 p154
H-bond Fun Fact
• 1984 survey of protein crystal data shows that “almost all groups capable of forming H-bonds do so.” (mainchain amides, polar sidechains)
Table 6-4
Figure 5-3
Fundamentals of Biochemistry
Third Edition
Fundamentals of Biochemistry
Third Edition
Chapter 7Protein Function: Myoglobin and Hemoglobin,
Muscle Contraction, and Antibodies
Chapter 7Protein Function: Myoglobin and Hemoglobin,
Muscle Contraction, and Antibodies
Copyright © 2008 by John Wiley & Sons, Inc.Copyright © 2008 by John Wiley & Sons, Inc.
Donald Voet • Judith G. Voet • Charlotte W. Pratt
Donald Voet • Judith G. Voet • Charlotte W. Pratt
Oxygen is transported to cellswhich are remote from air
•O2 is required in cells, in themitochondria for ATP production
aerobic metabolism
Glucose + O2 ----------------------------> ATP + CO2
oxidative phosphorylation
Normal Red Blood Cells have a flattened discoid shape rather than a spherical shape
vs.O2 O2O2
O2
O2 O2
O2O2O2O2
O2 O2 O2
O2
O2
O2O2 O2
O2
O2O2
O2O2
O2
O2
O2
Table 6-4
Chapter 7 Opener
Figure 7-1
Figure 7-2
Figure 7-3
Figure 7-4
Box 7-1
Figure 7-5