The world leader in serving science

Building on Our Industry Leadership

Marc N. CasperChief Operating Officer

Ian D. Jardine, PhDVice President, Global R&D

Pittcon 2009 Press ConferenceMarch 9, 2009

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The World Leader in Serving Science

We are the leading provider of analytical instruments, equipment, reagents and consumables, software and services

for research, analysis, discovery and diagnostics.

Size and Scale

$10.5 billion in revenues34,000+ employees in 40 countriesServing 350,000 customers in 150 countriesFortune 300 company

Unmatched Capabilities

Complete portfolioWorld-class technologiesCommercial and service strength

Leading Brands

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A Mission We are Proud of

We enable our customers to make the world healthier, cleaner and safer

CleanerHealthier Safer

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Our Strengths

Global industry leadership

Key competitive advantages• Broad portfolio• Diverse customer base• Global reach• Strong balance sheet

Excellent track record of financial performance

A partner you can count on

Ability to continuously invest in growth opportunities• Developing innovative products

• Invested $250 million in R&D in 2008• Strengthening commercial capabilities

• Extending our channel reach• Expanding in growing markets

• Focus on China and India

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A Compelling Value Proposition

TargetedInnovation

Extended BusinessPartner

Scientific Productivity

We deliver unmatched scientific productivity through our innovative technologies, services and systems.

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Thermo Scientific: New Products for Today’s Demands

Differentiated in performance and productivity

Voice of Customer

Ease of useAdvanced technologies for non-experts

Greater efficiency and productivity

Integrated workflowsData management

Better analytical performance

Speed and sensitivityPrecise quantitation

Broad applicationsLaboratoryIndustrial and field

SustainabilityEnergy efficiencyReduced solvent usage

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Fisher Scientific: One Source, Infinite Solutions

Providing customers with a growing portfolio of convenient sourcing and service options

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Helping our Customers Achieve their Goals

Targeted Innovation

Laboratory Productivity

Business Partner

Pharmaceutical Customer

Consolidated orderingE-commerce platformThird-party sourcingOutsourced services and asset management

Scientific collaborationMethods developmentApplication-based workflowsData management

Equipment standardizationStandard operating procedures and validationGlobal logistics network

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Expanding our Capabilities with Strategic Acquisitions

Open Biosystems: RNAiAffinity Bioreagents: Antibodies

Chemito Technologies:Routine analytical instruments

FiberLite: Carbon fiber centrifuge rotors

Hucoa Erloss, Afora, Bonsai: Extends European channels

Consumables and Reagents

EquipmentInstrumentation

Customer Channels

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The World Leader in Serving Science

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Pittcon 2009: New Products for Key Applications

Data Interpretation

Sample Analysis

Sample Preparation

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Pittcon 2009: New Products for Sample Preparation

Sample Preparation

Sample Analysis

Data Interpretation

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Pittcon 2009: New Products for Sample Preparation

Protein Catalogs

Electrodes

Meters

siRNA, shRNA, miRNABioreagents

Hamilton Infinity Fume Hood

Hamilton Distinction II Green Lab Furniture

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Pittcon 2009: New Products for Sample Analysis

Sample Analysis

Data Interpretation

Sample Preparation

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New Thermo Scientific Products for Sample Analysis

Accela Exactive™ LCMS

TSQ Vantage™

Niton XRF GOLDD™Titan 4000™

NSX Analyzer

Basic Research

Drug Discovery & Development

Environmental &Food Screening

Industrial & Product Testing

Petroleum & Chemical

Arena™

Chemistry Analyzer

A range of innovations, from research to routine testing

NanoDrop™

2000/2000cUV/Vis

R

Transcend TLX™ Access Max™

LCMS

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Quick, easy, accurate UV-Vis analysisLow or no sample prep, reduced solventsMore sensitivity

Thermo Scientific NanoDropCustomer Needs:

Our Response:Unique “all-in-one” Spectrophotometer

Ideal for DNA, RNA, proteins, cell culturesPatent-pending combination of micro-volume pedestal and built-in cuvette capability200X concentration vs. conventional specsBroad wavelength rangeKinetics capability

Basic Research

Revolutionary New Micro UV-Vis Capability

Dramatic advances in UV-Vis performance

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Accurate: absorbance accuracy and precision 2% and .002

Advanced: custom methods capability yes

Versatile: number of path lengths 7

Compact: footprint (cm) 14 x 20

Fast: measurement time (secs) <3 (cuvette)

Fast: measurement time (secs) <5 (pedestal)

Broad: wavelength range (nm) 190 - 840

Small: minimum sample size (µl) 0.5

Broad: concentration range (ng/µl) 0.4 – 15,000 ng/ul (dsDNA)

Thermo Scientific NanoDrop 2000c

Leading-Edge Performance

Key Specifications

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Intuitive, Clear, Easy-to-Use Software

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Greater sensitivity (S/N) for ultralow-level quantitationPrecision and reproducibilityMultiple analytes per run

Unmatched signal-to-noise performance exceeds customer expectations

Highest Triple Quad Sensitivity

Customer Needs:

Our Response:10X more sensitivity than any other triple quad

1,000 SRMs per second and 3,000 timed SRMs per LC run

Full peptide, protein quantitation

TSQ series 2.0.0 software

Thermo Scientific TSQ Vantage Mass Spec

Drug Discovery & Development

Hesi II probe

New sweep

cap

Patented S-lens

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TSQ Vantage Beats Existing SystemsSample Name: "Std 0.01" Sample ID: "" File: "08305rlc39a PPT Evap 8Mar08 4.wiff"Peak Name: "Dextromethorphan-d3" Mass(es): "275.2/171.2 amu"Comment: "" Annotation: ""

Sample Index: 31 Sample Type: Standard Concentration: 0.0100 Calculated Conc: 0.0109 Acq. Date: 3/9/2008 Acq. Time: 2:11:48 PM Modified: No Proc. Algorithm: IntelliQuan - MQII Noise Percentage: 93 Base. Sub. Window: 1.00 minPeak-Split. Factor: 2 Report Largest Peak: No Min. Peak Height: 200.00 cpsMin. Peak Width: 4.00 secSmoothing Width: 3 pointsRT Window: 30.0 secExpected RT: 2.72 minUse Relative RT: No Int. Type: Base To Base Retention Time: 2.69 minArea: 1892.34 countsHeight: 5.72e+002 cpsStart Time: 2.63 minEnd Time: 2.74 min

1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6Time, min

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nsity

, cps

2.68

2.59

3.23

2.82

3.072.78

3.412.85 3.132.95 3.582.40 3.34

RT: 0.98 - 3.96

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RT: 3.04 NL: 1.35E4TIC F: + c ESI SRM ms2 275.180 [171.049-171.051] MS ICIS tt-test_mix_124competitor

TSQ Vantage

>10X LOQ better than

competitor’sbest efforts

Unsurpassed triple quad performance

Dextromethorphan-d3In Rat Plasma

(LLOQ at 0.01 ng/mL)

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Environmental & Food Screening

Quantum Access MAX™

Advanced screening for routine applicationsHigher sensitivity and throughputStreamlined method development

High Performance for Routine Applications

The value choice for routine food safety, pharma, environmental and clinical applications

Thermo Scientific Workflow SolutionCustomer Needs:

Accela UHPLC™ TraceFinder™ Software

Simultaneous quantitation and structural confirmationFast +/- switching for high-speed multi-component trace analysis3000 timed SRMs per LC runNew TraceFinder software

Our Response:

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Accela-Access Max Performance in Pesticide Screening

Complex multi-residue pesticide analysis (10 ppt) in <3 minutes

Carpropamine

Daimuron

Tricyclazole

Carbaryl

Carbofuran

Siduron

Diuron

Time (minutes)

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End-to-End Workflow for Multiplexing LC/MS/MS

In-line sample extractionEnd-to-end workflow analysis

High-throughput benchmark for clinical and drug analysis

Customer Needs:Thermo Scientific Workflow Solution

Our Response:Doubles sample analysis throughputIncreases detection limits

New high performance ultralow dead volume LC pumps

Fully integrated software for multiplexed LC-MS

Transcend TLX™ Accela UHPLC™ TSQ Vantage™

Drug Discovery & Development

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Environmental & Food Screening

Full scan MS with HCD scanningWalk-up compound identification

• Pesticides, metabolites, tox screeningNew quantitation capabilitiesPowerful Pathfinder™ software

A Revolution in LC-MS

Cost effective target ID and compound identificationHigher throughput analysis with advanced mass accuracyEasy-to-use workflow enabler and productivity platform

Speed, spectra, ultrahigh resolution, superb accurate mass, and precise quantitation all in an affordable bench-top system

Accela UHPLC™

Customer Needs:Thermo Scientific Exactive

Our Response:

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1.20298.2741C18H35NO2Spiroxamine

1.70297.0556C14H14Cl2N2OImazalil

0.20296.1161C14H18ClN3O2Triadimenol

2.00295.0222C10H15O4PS2Fenthion-sulfoxide

1.40294.1368C15H20ClN3OPaclobutrazol

0.30294.1004C14H16ClN3O2Triadimefon

0.70253.0309C10H9ClN4SThiacloprid

1.20249.0192C9H10Cl2N2O2Linuron

0.90241.0963C9H13ClN6Cyanazine

0.10240.0786C12H14ClNO2Clomazone

6.50239.1503C11H18N4O2Pirimicarb

1.20237.1234C12H16N2O3Carbetamide

2.00233.0243C9H10Cl2N2ODiuron

2.50216.1011C8H14ClN5Atrazine

2.00215.0961C8H14N4OSMetribuzin

1.20213.0789C10H13ClN2OChlortoluron

1.10210.1125C11H15NO3Propoxur

Error [ppm] [M+H]Elemental CompositionComponent

The Value of Reproducible High Mass Accuracy

Fast chromatography (<15mins)Exactive running at 15,000 resolution

All molecular weight masses within ± 2.5 ppm except…

Total of about 110 pesticides(each ~ 250 ug/L)

in very complex horse feed matrix

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1.20298.2741C18H35NO2Spiroxamine

1.70297.0556C14H14Cl2N2OImazalil

0.20296.1161C14H18ClN3O2Triadimenol

2.00295.0222C10H15O4PS2Fenthion-sulfoxide

1.40294.1368C15H20ClN3OPaclobutrazol

0.30294.1004C14H16ClN3O2Triadimefon

0.70253.0309C10H9ClN4SThiacloprid

1.20249.0192C9H10Cl2N2O2Linuron

0.90241.0963C9H13ClN6Cyanazine

0.10240.0786C12H14ClNO2Clomazone

6.50239.1503C11H18N4O2Pirimicarb1.20237.1234C12H16N2O3Carbetamide

2.00233.0243C9H10Cl2N2ODiuron

2.50216.1011C8H14ClN5Atrazine

2.00215.0961C8H14N4OSMetribuzin

1.20213.0789C10H13ClN2OChlortoluron

1.10210.1125C11H15NO3Propoxur

Error [ppm] [M+H]Elemental CompositionComponent

The Value of Reproducible High Mass Accuracy

Unusually high error of 6.5 ppmRe-analyze @ higher resolution of 80,000

Only Orbitrap technology allows this level of confidence

Total of about 110 pesticides(each ~ 250 ug/L)

in very complex horse feed matrix

Pirimicarb

6.50

The world leader in serving science

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The Value of High Mass Accuracy and Ultrahigh Resolution

The Case for ExactiveA mixture of >100 pesticides, mycotoxins and veterinary drugs at different concentration levels in horse feed matrix analyzed at two resolution settings utilizing full scan accurate mass measurements (+/- 2ppm)

100k

10K

0 20 40 60 80 100

250

50

10

% Detected

Det

ecte

d co

mpo

unds

ppm

45%

10K resolution can’t detect known chemicals

Vastly superior analytical results with Orbitrap performance

99%

100%

93%

32%

11%

250

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The power of 100K resolution

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The Value of High Mass Accuracy and Ultrahigh Resolution – Quantitation

Concentration ranging from

0.2 ppb to 500 ppb

Dextrorphanwith internal

standard0.5 - 500 pg on-column

Concentration ranging from

0.2 ppb to 500 ppb

Dextrorphanwith internal

standard0.5 - 500 pg on-column

Lowest Data point

profile

+/- 5 ppm

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Drug Discovery & Development

Enabling the right workflow for the right userDeveloped methods significantly streamline analysis Links into other software:

• Thermo Scientific ToxID • Thermo Scientific Xcalibur

New Pathfinder Screening Software for Exactive

Pathfinder leverages full instrument capabilities

Thermo Scientific Pathfinder

Walk-up user Experienced user

Reports

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Orbitrap Technology for Routine Screening Applications

Exactive™ will displace TOFs and QTOFs!

Thermo Scientific Exactive

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Easy sample introductionSimple operationIncreased analysis speed and sensitivity

Total nitrogen and total sulfur (TN/TS) analysis in <2 minutesUp to 60% reduction in bench spaceNew nebulizing injection technique with high efficiency folded combustion tubeNSX visual software

Petroleum & Chemical

Thermo Scientific TITAN 4000 NSX Analyzer

New capability for QC with increased productivity and lower operating costs for petrochemical and refinery industries

Customer Needs:

Our Response:

Superior Total NSX Analysis in a Small Footprint

EST AnalyticalBooth 1816

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Next-Generation Portable XRF Elemental Analysis

Breakthrough lab-quality performance in a handheld detector

Other Technology

Smaller AreaDetector Large Area

Detector

Thermo ScientificNiton XL3t GOLDD

Samples

10x faster than conventional detectors 3x more precise than traditional silicon drift detectorsProprietary GOLDDTM Large Area Drift Detector Light element detection without helium or vacuum purging

Customer Needs:Speed and sensitivityPortable and field rugged Identify multiple elementsReal time data and simple software interface

Industrial & Product Testing

Our Response:

Thermo Scientific Niton XL3t GOLDD

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“Clinical Chemistry” Analyzer for Non-clinical Labs

Fast and efficient analysis in an advanced all-in-one system

• Colorimetric and enzymatic applications• 45 reagent positions• Wavelength range 340 to 880 nm• Automatic barcode ID

Accurate QC and analysis for pharma, agricultural, food

• Example: Asparagine + glucose = potentialacrylamide formation

Sample throughput up to 600 tests per hour

Customer Needs:

Industrial & Product Testing

Our Response:

Easy and rapid automated methodsWalk-away analysisSingle system for multiple applications

Thermo Scientific Arena Analyzer

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Pittcon 2009: New Data Interpretation Solutions

Data Interpretation

Sample Analysis

Sample Preparation

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Pittcon 2009: New Data Interpretation Solutions

OMNIC Specta on Raman

Pathfinder TraceFinder

Enterprise Insights

Connects

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Maximize customer ROI from previous software investments

Pittcon 2009: New Data Interpretation Solutions

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A Mission We are Proud of

We enable our customers to make the world healthier, cleaner and safer

CleanerHealthier Safer

Pharma & BiotechQuantitationSpeedSelectivityData management

Environmental &Industrial

PortabilitySpeedSensitivityRobustness

Food SafetyScreeningConfirmationThroughputEase of use

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See it All!

Mass Spectrometryand Chromatography

Water Purification

Water Analysis Instruments

Elemental AnalysisUV-Visibleand Fluorescence

Particle Technology

LIMS, COS andSpectroscopySoftware

ChromatographyConsumables

Mass Spectrometryand Chromatography

HandheldXRF AnalyzersElemental Analysis

Molecular Spectroscopy

Laboratory Furnitureand Fume Hoods

Information

Discrete PhotometricAnalyzers

TRAM

Blue Crew

Fisherbrand and Fisher Scientific products Nucleus

Life Science

Chemicals

Chromatography

Spectroscopy

SamplePreparation

Micro/AnalyticalTechnologies

Fisherbrand andFisher Scientific products

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Your Passport to Scientific Innovation

Visit Thermo Scientific Booth 1432

Mass Spectrometryand Chromatography

Water Purification

Water Analysis Instruments

Elemental AnalysisUV-Visibleand Fluorescence

Particle Technology

LIMS, COS andSpectroscopySoftware

ChromatographyConsumables

Mass Spectrometryand Chromatography

HandheldXRF AnalyzersElemental Analysis

Molecular Spectroscopy

Laboratory Furnitureand Fume Hoods

Information

Discrete PhotometricAnalyzers