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The CrEST™ X-Light™ Confocal Module brings the latest advancements in multi-dimensional high-content imaging and analysis without sacrificing your productivity. As scientists increasingly apply high-content analysis to stem cell characterization, multi-dimensional cell models, primary cultures and tissues, the challenges posed by these applications demand new types of imaging techniques. The Thermo Scientific™ ArrayScan™ VTI/XTI High Content Analysis (HCA) Readers are available with an integrated confocal module combining leading high-content technologies and software with the latest advances in 2D and 3D imaging.

h i g h c o n t e n t a n a l y s i s

Thermo Scientific ArrayScan Confocal ModuleMultidimensional high content imaging and analysis

Capabilities

• The CrEST X-Light incorporates the latest generation high-speed Nipkow spinning disk

• Software-controlled switching between 45µm and 70µm pinholes for low and high NA flexibility

• Robust long-life, seven-color Illumination (four-color if using a five-color widefield light engine) using LED Light Engine technology for laser-like performance and unparalleled ease of use

• User-definable z-range with 0.1µm resolution step size for confocal slices

• Multiple options for 3D projections including new software for enhancing widefield imaging capabilities

Benefits

• Proven – Advanced technology with proven history from the industry leader

• Flexibility – Multiple pinhole and projection options, allowing for enhanced multidimensional imaging capabilities

• Simple – No laser alignment and a simple confocal setup allow you to investigate and scan using multiple modes as needed by your biology

• Quality – Unique solid-state illumination and high-efficiency filters create a long-life, robust solution with little downtime and lowered cost of ownership

• Compatible – Protect the investment in your current ArrayScan XTI HCA Reader with the field retrofittable confocal module

Figure 1: 3t3 cells treated with cytochalasin D. green represents tubulin, red microtubules and blue nuclei.

Figure 2: liver slices. Blue represents nuclei.

©2014 Thermo Fisher Scientific Inc. All rights reserved. X-Light is a trademark of Crisel Electrooptical Systems & Technology s.r.l. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.

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Deeper Biological Insights

With the ArrayScan XTI HCA Reader and integrated X-Light Confocal Module, multi-dimensional structures can be imaged more clearly, yielding more detailed information and deeper understanding about biological change.

Multiple projection options for image analysis along with the ability to save the stack of images to create 3D movies permits you to investigate both thick and thin cell samples like never before.

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Total footprint of the ArrayScan XTI HCA Reader with Confocal Module 96.8(W) x 87.63(D) x 50.8(H) cm

10,000RPM Dual Patterned Nipkow Spinning Disk

40µm and 70µm software switchable

Pre-aligned seven-color LED Illumination (four-color if using a five-color widefield LED)

Compatible with Thermo Scientific™ HCS Studio™ Cell Analysis Software and Thermo Scientific™ Store™ Image and Database Management Software

Compatible with the ArrayScan VTI/XTI HCA Readers

Dimensions

Spinning Disk

Pinholes

Illumination

Software

ArrayScan Compatibility

Confocal Module Specifications

Figure 3: shows a maximum projection using widefield imaging.

Figure 4: shows a maximum projection using the X-light confocal Mode.

Angiogenic Tubes: Tissue samples were

imaged in the FITC Channel and two, 2µm thick

Z-slice images were captured for projection

thermoscientific.com/highcontent

USA +1 800 432 4091 info.cellomics@thermofisher.com

Asia +81 3 5826 1659 info.cellomics.asia@thermofisher.com

Europe +32 (0)53 85 71 84 info.cellomics.eu@thermofisher.com