this is a 16:9 powerpoint slide - pathology...may 03, 2018 · verruca vulgaris. 5/22/2018 6...
TRANSCRIPT
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Napa Valley Dermatopathology 2018
Nail pathology II: Non-melanocytic Neoplasms
Beth S. Ruben, MDDirector, Dermatopathology
Palo Alto Medical Foundation, Palo Alto, CA
Professor of Dermatology
University of California, San Francisco
Epithelial and other neoplasms
of the nail unit
• Some are counterparts to those found
elsewhere
• Some are entities unique to this site
• Unusual features can create diagnostic
quandaries
• Diagnosis often depends on the adequacy of the
specimen and the clinical history
Epithelial and other neoplasms
• Benign
– Onychopapilloma
– Subungual epidermoid
inclusions
– Onychomatricoma
– Onychocytic matricoma
– Superficial acral
fibromyxoma
• Malignant
– SCCIS/SCC
– Keratoacanthoma
– Subungual tumors of
incontinentia pigmenti
– Onycholemmal CA
– Onychocytic CA (?)
– Papillary adenoCA
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Tosti A, Schneider SL, Ramirez-Quizon MN, Zaiac M, Miteva M.
Clinical, dermoscopic, and pathologic features of onychopapilloma: A
review of 47 cases. Journal of the American Academy of Dermatology.
2016;74(3):521-526.
Onychopapilloma
• Clinical findings
– Erythronychia
– Splinter hemorrhage
– Melanonychia
– Leukonychia
– Distal hyperkeratosis
– Distal splitting
Courtesy of Tara Miller, MD
Histologic features
• Hyperplasia of distal matrix and nail bed epithelium,
papillated distally
• Distal subungual hyperkeratosis/parakeratosis
• Hemorrhage
• Matrical metaplasia (eosinophilic, anucleated cell layer in
nail bed)
• Large and multinucleate distal nail bed keratinocytes
• Sometimes pigmentation (melanocytic activation)
• Often need intact lesion to make definitive diagnosis
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Courtesy of Leslie Robinson-Bostom, MD
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Baran R, Perrin C. Longitudinal erythronychia with distal
subungual keratosis: onychopapilloma of the nail bed and
Bowen’s disease. Br J Dermatol. 2000;143(1):132-135.
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Courtesy, of Jon Starr, MD
Verruca vulgaris
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Subungual epidermoid inclusions
• Small aggregates of keratinocytes or cysts that can be found under the epithelium of the nail bed
• An incidental finding, or associated with nail dystrophy, especially a shortened and dystrophic nail plate, or clubbing
• A history of trauma is common, and there may be associated underlying bony abnormalities as well
• There may be associated hyperkeratosis of the nail bed• Less cystic variants can be mistaken for squamous cell
carcinoma or other neoplasms
Lewin K. Br J Dermatol 77:241, 1965
Lewin K. Br J Dermatol 81(671),1969
Fanti PA, Tosti A. Dermatologica 178(4):209-12, 1989
Bukhari IA, Al-Mugharbel R. Saudi Med J Apr;25(4):522-3, 2004Telang GH and Jellinek N. J Am Acad Dermatol 56:336-9, 2007
Ruben BS, LeBoit PE. J Cutan Pathol. 2008 Jan;35(1):97.
Collection of Monica Lawry, M.D.
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OnychomatricomaBaran and Kint
Onychomatricoma
Clinical presentation
Thickened nail plate Transverse overcurvature
Splinter
hemorrhages
Nodule
Courtesy of Monica Lawry, MD
Hollow area within tumor
Nail bed
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Specimen for pathology
Onychomatricoma
Clinical features:• Mean age 50.5 (24-68), lighter-skinned patients• Fingers most often affected, esp. thumb and index• Female to male 2.16:1• Thickened yellowish nail, transverse overcurvature, splinter
hemorrhages, sometimes pigmented• Nodular area corresponding to the matrix• Rarely recurs after surgery
Perrin C, Baran R, Balaguer T, et al. Am J Dermatopathol. 2010;32(1):1-8.
Di Chiacchio N, Tavares GT, Tosti A, et al. Br J Dermatol. 2015;173(5):1305-1307.
Reserva JL, Ruben BS, Venna SS. Skin Appendage Disord. 2017;3(1):32-35.
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OnychomatricomaKey histologic features: • Multiple fibroepithelial projections• Thick V-shaped keratogenous zone, mimics normal matrix• Matrical hyperplasia of varying degree• “Glove-finger” appearance of nail plate and matrix interaction• Altered nail plate thin proximally, thick distally, with multiple
cavities (wormwood)• Fibrocellular stroma of varying degree
– CD34+; CD99, S100, EMA-– More cellular superficially, perpendicular collagen bundles deeply– Myxoid stroma similar to superficial acral fibromyxoma, rare
Normal nail
Fibroepithelial
component
Thick, altered nail plate
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Courtesy of A. Christine Miller, MD
Pigmented onychomatricoma
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Pleomorphic OM
Courtesy of Laura Pincus, MD
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“Pleomorphic” OM
• Only seven cases now reported:
– 2 as “unguioblastic fibroma”
– 2 possibly as pleomorphic fibroma
– 2 in a large series of 19 cases of OM
• Although pleomorphic, no history of adverse biologic behavior
Fernandez-Flores’ A, Barja-Lopez J-M. J. Cutan. Pathol. 2014;41(7):555-560.
Petersson F, Tang ALY, Jin ACE, Barr RJ, Lee VK. Am J Dermatopathol 2010;32(4):387-391.
Ki-67
Nail clipping for diagnosis
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Miteva M. et al. Arch Dermatol.
2011;147(9):1117–1118.
Tallon B, Strydom F, Emanuel PO.
J Cutan Pathol. 2013;40(1):2–3.
Perrin C, Baran R, Balaguer T, et al. Onychomatricoma: new clinical and
histological features. A review of 19 tumors. Am J Dermatopathol. 2010;32(1):1-8.
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OnychomatricomaDifferential Diagnosis- Histologic
• Angiofibroma (Koenen’s tumor)• Acquired digital fibrokeratoma• Cellular digital fibroma• Perineurioma• Pleomorphic fibroma• Superficial acral fibromyxoma• Verruca vulgaris• SCC in situ (rarely)
CD34+
EMA
S100
CD99
Superficial acral fibromyxoma
Courtesy of Brad Naylor, DPM
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CD34
EMA
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Fetsch JF, Laskin WB,
Miettinen M. Hum Pathol.
2001 Jul;32(7):704-14.
Superficial acral fibromyxomaClinical features
• A benign spindle cell proliferation• Predilection for hands and feet, fingers and toes,
often with close relationship to nail unit• Broad age range (mean, 43)• Duration 3 mos to 30 years• Size 0.6 cm-5 cm, may impinge on bone• Behavior: most did not recur after excision
Fetsch JF, Laskin WB, Miettinen M. Hum Pathol. 2001 Jul;32(7):704-14.
Superficial acral fibromyxomaHistologic features
• Spindled to stellate cells • Random, loose storiform or fascicular patterns• Myxoid to collagenous, prominent mast cells• Occasional multinucleate cells, rare mitoses• CD34+, CD99 variable +, EMA focal/–• Nestin positive, RB1 loss• Probable fibroblastic differentiation
Fetsch JF, Laskin WB, Miettinen M. Hum Pathol. 2001 Jul;32(7):704-14.
Cullen D, Díaz Recuero JL, Cullen R et all. Am J Dermatopathol. 2017;39(1):14-22.
Agaimy A, Michal M, Giedl J et al. Hum Pathol. 2017;60:192-198.
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Chattopadhyay M, Farrant P, Higgins E, Hay R, Calonje E. Clin Exp Dermatol. 2010 Oct;35(7):807-9
Courtesy of Jeff North, MD
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Pleomorphic fibroma
Angiofibroma
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Perrin C, Cannata GE, Bossard C, et al. Onychocytic matricoma
presenting as pachymelanonychia longitudinal. A new entity (report of
five cases). Am J Dermatopathol. 2012;34(1):54–59.
Courtesy of Mark Holzberg, MD
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Melan-A
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Perrin C, Cannata GE, Bossard C, et al. Onychocytic matricoma presenting as
pachymelanonychia longitudinal. A new entity (report of five cases). Am J
Dermatopathol. 2012;34(1):54–59.
Acanthotic type
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Papillomatous Keratogenous
Melanocytes and melanin
Bon-Mardion M, Poulalhon N, Balme B, Thomas L. Ungual
seborrheic keratosis. J Eur Acad Dermatol Venereol.
2010;24(9):1102–1104.
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Wanat KA, Reid E, Rubin AI. Onychocytic matricoma: a new, important nail-unit
tumor mistaken for a foreign body. JAMA Dermatol. 2014;150(3):335-337.
Stinco G, Errichetti E, Patrone P. Ungual seborrhoeic keratosis: report of a case
and its dermoscopic features. J Eur Acad Dermatol Venereol. 2014.
doi:10.1111/jdv.12866.
Nail dystrophy began 3 years ago, slowly more raised
Courtesy of Drs. Jane Bellet and Ken Ellington
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proximal
distal
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SCC of the nail unit
• Most common tumor of nail unit, but still
uncommon
• Atypical clinical presentations the rule– Dystrophy, onycholysis, ulceration, paronychia, nail loss, and
rarely longitudinal melanonychia
• Predisposing factors– Immunosuppression
– Oncogenic HPV
– Radiodermatitis
Squamous cell carcinomaIn situ Invasive
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Partial nail plate avulsion reveals nail bed abnormality
Sneaky SCC
Courtesy of Monica Lawry, MD
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SCCIS of the nail unit
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Pigmented SCCIS
Subungual keratoacanthoma
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von Kossa
Painful subungual tumorsof incontinentia pigmenti
• Well-recognized but rare complication of IP, a late manifestation
• Corresponds to the verrucous stage, IP
• Fingers > toes
• DDX: subungual keratoacanthoma, verruca, epidermoid cysts, subungual fibroma, chronic paronychia
• Intense pain and osteolysis may occur
• Excision or amputation may be necessary
• Retinoids have been used with some promise
Young et al. JAAD 2005
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Chaser BE, Renszel KM, Crowson AN, et al. Onycholemmal carcinoma: A morphologic comparison of 6 reported cases. J. Am. Acad. Dermatol. 2013;68(2):290–295.
• Clinical features:
– Female to male 1:1
– Middle age to older patients
– Finger: thumb: toe: unknown 3:1:1:1
– Symptoms/signs: ulceration, swelling, paronychia-like, onycholysis, periungual erythema, pain
– May abut the bone but no bony involvement
– Indolent course (no aggressive behavior)
– Treatment: Mohs surgery, excision, nail unit excision, radiation, amputation
– Conservative treatment advocated
Chaser BE, Renszel KM, Crowson AN, et al. Onycholemmal carcinoma: A morphologic
comparison of 6 reported cases. J. Am. Acad. Dermatol. 2013;68(2):290–295.
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• Histologic features
– Cytologically bland
– Poorly circumscribed, infiltrative pattern
– Lobular and cystic
– Abrupt keratinization (reminiscent of proliferating pilar
tumor)
– Authors consider this an acral SCC
– 1 case studied was negative for HPV
Chaser BE, Renszel KM, Crowson AN, et al. Onycholemmal carcinoma: A morphologic
comparison of 6 reported cases. J. Am. Acad. Dermatol. 2013;68(2):290–295.
Courtesy of Michael Morgan, MD
Onycholemmal carcinoma
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Perrin C, Langbein L, Ambrossetti D, Erfan N, Schweizer J, Michiels J-F. Onychocytic carcinoma: a new
entity. Am J Dermatopathol. 2013;35(6):679-684.
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Perrin C, Langbein L, Ambrossetti D, Erfan N, Schweizer J, Michiels J-F. Onychocytic carcinoma: a new
entity. Am J Dermatopathol. 2013;35(6):679-684.
Wang L, Gao T, Wang G. Invasive onychocytic carcinoma. J Cutan Pathol. 2015
May;42(5):361-7
• 51 yo woman, ulceration of left ring finger, 4 years
• Began with trauma, then formed a longitudinal split
• Gradual destruction of whole nail bed
• First biopsy inconclusive
Wang L, Gao T, Wang G. Invasive onychocytic carcinoma. J Cutan Pathol 2015 May;42(5):361-7.
Invasive
Matrix-like
cytology
Keratinization
Retiform
contour
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Jih DM, Elenitsas R, Vittorio CC, Berkowitz AR, Seykora JT. Aggressive
digital papillary adenocarcinoma: a case report and review of the literature.
Am J Dermatopathol. 2001;23(2):154-157.
Digital papillary adenocarcinomaHistory
• First described by Helwig, 1979 (AAD CPC)
• Rare low grade malignant adnexal tumor
• Formerly, aggressive digital papillary adenoma (ADPA)
• Despite somewhat bland histologic appearance, some cases found
to behave aggressively
• 2000, Duke et al propose ADPA is malignant without a benign
counterpart, renaming as PDA to reflect this behavior, suggest
aggressive treatment
• 2009, Hsu et al suggest that wide excision may be adequate for
some more limited cases (use Ki-67 proliferation index as a guide)
Digital papillary adenocarcinomaClinical features
• Painful or painless cystic mass, acral skin, volar surfaces of fingers and toes
• Male predominance
• Unusual presentations include as PG, hemangioma, SCC-like, osteomyelitis, soft tissue infection, and paronychia
• Preferred location: between nail unit and DIP
Kao GF, Helwig EB, Graham JH. J Cutan Pathol. 1987 Jun;14(3):129-46. Duke WH, Sherrod TT, Lupton GP. Am J Surg Pathol. 2000 Jun;24(6):775-84.
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Courtesy of Tara Miller, MD
Digital papillary adenocarcinomaHistology
Mixed papillary, tubuloalveolar, solid, cystic patterns;
variable atypia, mitotic rate, necrosis
Squamous metaplasia, clear cells, spindle cells
Stains with S100, CEA, p63
Also EMA, ER, PR, CK7, CK77, PHLDA, SMA, AR
May contain myoepithelial cells
No histologic features predict biologic behavior
Ki-67 proliferation rate?Suchak R et al. Am J Surg Path.36:1883-91, 2012
Weingertner N et al. J Am Acad Dermatol. 2017;77(3):549-558.e1.
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Digital papillary adenocarcinomaDifferential diagnosis
• Metastatic carcinoma
• Tubular apocrine adenoma
• Hidradenoma
Digital papillary adenocarcinomaPrognosis and treatment
• Local recurrence in 5%, up to 50% if not widely
excised
• Metastasis 12-14%, often to lung (70%)
• In some series, metastatic rate approaches 50%
• Treatment: wide local excision, amputation,
Mohs surgery, sentinel node sampling??
Morita R et al. Plast Reconstr Surg. 2006 Feb;117(2):710-2.Rismiller K, Knackstedt TJ Dermatol Surg. March 2018.
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Take home points
• Epithelial and other neoplasms may have
distinctive features in the nail unit
• Orientation of the tissue may be key to recognition
• Determining benign versus malignant can
sometimes be tricky
• Some diagnoses are unique to this site
• Be on the lookout for new entities!