this might sound crazy but….. · 2016. 8. 10. · david j. finitsis*, jennifer a. pellowski,...

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This might sound crazy but….. Thinking outside the box in ART adherence Dr Tom Boyles Department of Infectious Diseases and HIV Medicine, UCT

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Page 1: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

This might sound crazy but…..Thinking outside the box in ART

adherence

Dr Tom Boyles

Department of Infectious Diseases and HIV Medicine, UCT

Page 2: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

Fig 2 Kaplan-Meier plot for survival in patients defined as adherent or not adherent (<95% or

≥95% adherence).

Kiboneka A et al. BMJ 2009;338:bmj.b201

©2009 by British Medical Journal Publishing Group

Page 3: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 4: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 5: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 6: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 7: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 8: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 9: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 10: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 11: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 12: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 13: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 14: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 15: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 16: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

Adherence aids

Page 17: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 18: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 19: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 20: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

Long-acting injectable nanoformulations

Page 21: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 22: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 23: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

'Remote control' contraceptive chip

Page 24: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

X out TB: Monitoring Patient Compliance with Tuberculosis Treatment Regimens

Page 25: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 26: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 27: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 28: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 29: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

35,029 participantsr = 0・19 Low-resource settings

Page 30: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 31: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

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and antidepressant

Page 32: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 33: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 34: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 35: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 36: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

ADHERENCE

Page 37: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 38: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

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and addictive drug

Page 39: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),
Page 40: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

Characteristics of drug

• Cheap

• Induces stable addiction (24hrs)

• Limited euphoric state

• Minimal drug interactions

• Minimal side effects

• Limited street value

• Not easily obtainable elsewhere

• Single preparation available

Page 41: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

Candidate compounds

• Opiates?

– Buprenorphine

– Oxycodone

– Oxymorphone

• Stimulants?

• Relaxants?

Page 42: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),

SAVE TAC, SAVE LIVES

SOUTH AFRICA NEEDS TAC NOW MORE THAN EVER!

Donate TODAY!

www.tacgivengain.org

Page 43: This might sound crazy but….. · 2016. 8. 10. · David J. Finitsis*, Jennifer A. Pellowski, Blair T. Johnson of Psychology, Center for Health, Intervention, & Prwentbn (CHIP),