thorax · primarycardiac angiosarcoma causing rupture ofthe heart and spontaneous bilateral...
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ThoraxThe Journal of the British Thoracic Society(President: J B L HOWELL)
Executive Editor: ANNE E TAT5ERSFIELD
Contents January 1989 Vol 44 No 1EDITORIALAcute bronchiolitis in infancy: treatment and prognosis AD MILNER, M MURRAY pages 1-5ORIGINAL ARTICLESPrognostic value of bronchoalveolar lavage in sarcoidosis: the critical influence of disease presentationK WARD, C O'CONNOR, C ODLUM, MX FITZGERALD pages 6-12Reversibility and reproducibility of histanmine induced plasma leakage in nasal airways C SVENSSON,CR BAUMGARTEN, U PIPKORN, U ALKNER, CGA PERSSON pages 13-8Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a doubleblind crossover study T EKSTROM, BR LINDGREN, L TIBBLING pages 19-23Effect of three weeks' treatment with budesonide on in vitro contractile and relaxant airway effects in therat B GUSTAFSSON, CGA PERSSON pages 24-7Beta adrenoceptor binding and induced relaxation in airway smooth muscle from patients with chronicairflow obstruction CJ VAN KOPPEN, JF RODRIGUES DE MIRANDA, AJ BELD, CLA VAN HERWAARDEN,J-WJ LAMMERS, CAM VAN GINNEKEN pages 28-35Effect of changing dietary sodium on the airway response to histamine PGJ BURNEY, JE NEILD, CHC TWORT,S CHINN, TD JONES, WD MITCHELL, C BATEMAN, IR CAMERON pages 36-41Carcinoma of the oesophagus in Transkei: treatment by intubation MH COTTON, AM SAMMON pages 42-7Diathermy resection and radioactive gold grains for palliation of obstruction due to recurrence of bronchialcarcinoma after external irradiation SJM LEDINGHAM, P GOLDSTRAW pages 48-51Influence of lung volume in sleep apnoea F SERIES, Y CORMIER, N LAMPRON, J LA FORGE pages 52-7Atrial natriuretic peptic concentrations in hypoxic secondary pulmonary hypertension: relation tohaemodynamic and blood gas variables and response to supplemental oxygen RJD WINTER, AC DAVIDSON,D TREACHER, RM RUDD, JV ANDERSON, L MELEAGROS, SR BLOOM pages 58-62Anomalous pulmonary venous drainage shown by duplex sonography, computed tomography, and plainradiography P HUEBSCH, A NEUHOLD, H MAYR, D GLOGAR pages 63-5HISTORICAL NOTEAn early report of growth of an Aspergillus species on the wall of a lung cavity L DOYLE pages 66-7
SHORT REPORTSBronchoscopy of symptom free patients infected with human immunodeficiency virus for detection ofpneumocystosis JD LUNDGREN, M ORHOLM, TL NIELSEN, J IVERSEN, J HERTZ, JO NIELSEN pages 68-9Rheumatoid arthritis with extensive lung lesions C FELLBAUM, W DOMEJ, H POPPER pages 70-1Bilateral clicking ribs W PARRY, I BRECKENRIDGE, YF KHALIL pages 72-3Chylopericardium as a complication of mitral valve replacement Y BAR-EL, A SMOLINSKY, A YELLINpages 74-5Successful percutaneous balloon occlusion of a large pulmonary arteriovenous malformationCJ DUGGAN, VS GRINNELL, PC PIGOTT pages 76-7Primary cardiac angiosarcoma causing rupture of the heart and spontaneous bilateralpneumothorax AJ LOBO, RJ BUTLAND, S STEWART, JM SHNEERSON pages 78-9CORRESPONDENCESpontaneous pneumothorax due to metastatic carcinoma of the rectum S SHARMA, M RAJANI page 80Bilateral empyema and purulent pericarditis due to Haemophilus influenzae capsular type b A MIER page80BOOK NOTICE page 80NOTICE page 80
ASTM CODEN: THORA 7 44(1) 1-80 1989 ISSN 0040-6376
Published by British Medical Association, Tavistock Square, London WCCIH 9JRand printed in England by Eyre & Spottiswoode Ltd, London and Margate.
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Contents 1989No. I JANUARY
PAGE
EDITORIAL
Acute bronchiolitis in infancy: treatment and prognosis AD MILNER, M MURRAY ...... ......................... I
ORIGINAL ARTICLES
Prognostic value of bronchoalveolar lavage in sarcoidosis: the critical influence of disease presentation K WARD,C O'CONNOR, C ODLUM, MX FITZGERALD..................................................................... 6
Reversibility and reproducibility of histamine induced plasma leakage in nasal airways C SVENSSON,CR BAUMGARTEN, U PIPKORN, U ALKNER, CGA PERSSON ........ ............................................ 13
Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blindcrossover study T EKSTROM, BR LINDGREN, L TIBBLING ................................................... 19
Effect of three weeks' treatment with budesonide on in vitro contractile and relaxant airway effects in the ratB GUSTAFSSON, CGA PERSSON ............................................................................. 24
Beta adrenoceptor binding and induced relaxation in airway smooth muscle from patients with chronic airflowobstruction CJ VAN KOPPEN, JF RODRIGUES DE MIRANDA, AJ BELD, CLA VAN HERWAARDEN, J-WJ LAMMERS,
CAM VAN GINNEKEN ..................................................................................... 28
Effect ofchanging dietary sodium on the airway response to histamine PGJ BURNEY, JE NEILD, CHC TWORT, S CHINN,TD JONES, WD MITCHELL, C BATEMAN, IR CAMERON ......................................................... 36
Carcinoma of the oesophagus in Transkei: treatment by intubation MH COTTON, AM SAMMON ..... ............. 42Diathermy resection and radioactive gold grains for palliation of obstruction due to recurrence of bronchial
carcinoma after external irradiation SJM LEDINGHAM, P GOLDSTRAW ...................................... 48Influence of lung volume in sleep apnoea F SERIES, Y CORMIER, N LAMPRON, J LA FORGE ..... .................... 52Atrial natriuretic peptic concentrations in hypoxic secondary pulmonary hypertension: relation to haemodynamic
and blood gas variables and response to supplemental oxygen RJID WINTER, AC DAVIDSON, D TREACHER,RM RUDD, JV ANDERSON, L MELEAGROS, SR BLOOM .......................................................... 58
Anomalous pulmonary venous drainage shown by duplex sonography, computed tomography, and plainradiography P HUEBSCH, A NEUHOLD, H MAYR, D GLOGAR ................................................ 63
HISTORICAL NOTE
An early report of growth of an Aspergillus species on the wall of a lung cavity L DOYLE ..... .................. 66
SHORT REPORTS
Bronchoscopy of symptom free patients infected with human immunodeficiency virus for detection ofpneumocystosis JD LUNDGREN, M ORHOLM, TL NIELSEN, J IVERSEN, J HERTZ, JO NIELSEN ..... ................ 68
Rheumatoid arthritis with extensive lung lesions C FELLBAUM, W DOMEJ, H POPPER............................. 70Bilateral clicking ribs W PARRY, I BRECKENRIDGE, YF KHALIL ................................................. 72Chylopericardium as a complication of mitral valve replacement Y BAR-EL, A SMOLINSKY, A YELLIN ..... ........ 74Successful percutaneous balloon occlusion of a large pulmonary arteriovenous malformation CJ DUGGAN,
VS GRINNELL, PC PIGOTT ....... . .......................................................................... 76Primary cardiac angiosarcoma causing rupture of the heart and spontaneous bilateral pneumothorax AJ LOBO,
RJ BUTLAND, S STEWART, JM SHNEERSON................................................................... 78
CORRESPONDENCE
Spontaneous pneumothorax due to metastatic carcinoma of the rectum S SHARMA, M RAJANI................... 80Bilateral empyema and purulent pericarditis due to Haemophilus influen-ae capsular type b A MIER............. 80
BOOK NOTICE ............................................................................................... 80
NOTICE ...................................................................................................... 80
No. 2 FEBRUARYEDITORIAL
Is current treatment increasing asthma mortality and morbidity? EA MITCHELL ................................ 81
ORIGINAL ARTICLES
Combined use of non-invasive techniques to predict pulmonary arterial pressure in chronic respiratory diseaseJM BISHOP, M CSUKAS .....................................................................................5
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Patient self care in acute asthma B SIBBALD .................. ............................................... 97Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by
platelet activating factor in man KF CHUNG, G DENT, PJ BARNES .......................................... 102Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic
subjects KF CHUNG, PJ BARNES.......................................................................... 108Relation of airway responsiveness to duration of work in a dusty environment P ERNST, RE DALES, F NUNES,
MRBECKLAKE...................................................... ......................................116Increase in ventilation caused by aminophylline in the absence of changes in ventral medullary extracellular fluid
pH and carbon dioxide tension S JAVAHERI, JAM EVERS, LJ TEPPEMA ....................................... 121Hyaluronan and type III procollagen peptide concentrations in bronchoalveolar lavage fluid in idiopathic
pulmonary fibrosis L BJERMER, R LUNDGREN, R HALLGREN................................................ 126Impaired non-specific delayed cutaneous hypersensitivity in bird fancier's lung R ORRIOLS, F MORELL, V CURULL,
A ROMAN, G SAMPOL...................................................................................... 132Cardiovascular and hypokalaemic effects of inhaled salbutamol, fenoterol, and isoprenaline J CRANE, C BURGESS,
R BEASLEY.............................................................................................. 136Oesophagogastrectomy in patients over 70 DD MUEHRCKE, DK KAPLAN, RJ DONNELLY .......................... 141Refractory period following bronchoconstriction provoked by histamine in asthmatic subjects MJ CONNOLLY,
SC STENTON, AJ AVERY, EH WALTERS, DJ HENDRICK ......................................................... 146Increased incidence of pulmonary tuberculosis in chronic interstitial lung disease Y SHACHOR, D SCHINDLER,
A SIEGAL, D LIEBERMAN, Y MIKULSKI, I BRUDERMAN ........................................................ 151
SHORT REPORTS
Malignant primary pulmonary paraganglioma JRW HANGARTNER, TM LOOSEMORE, M BURKE, JR PEPPER.......... 154Occupational asthma in a pharmaceutical worker exposed to penicillamine F LAGIER, A CARTIER, I DOLOVICH,
J-L MALO................................................................................................ 157
CORRESPONDENCEFall in peak expiratory flow during haemodialysis in patients with chronic renal failure RK BEAUCHAMP;
AJ WILLIAMS, A DAVENPORT .............................................................................. 159
BOOK NOTICE................................................................................................ 159
NOTICE...................................................................................................... 160
CORRECTION
British Thoracic Society proceedings (LS HILL) .............. ................................................ 160
No. 3 MARCH
EDITORIAL
Muscarinic receptor subtypes: implications for lung disease PJ BARNES ....................................... 161
ORIGINAL ARTICLES
Ethnic differences in prevalence of asthma symptoms and bronchial hyperresponsiveness in New Zealandschoolchildren PK PATTEMORE, MI ASHER, AC HARRISON, EA MITCHELL, HH REA, AW STEWART ..... ........... 168
Six years' experience with perthoracic core needle biopsy in pulmonary lesions A MORGENROTH, HP PFEUFFER,M AUSTGEN, Hi VIERECK, F TRENDELENBURG .......1......................................................177
Supplemental oxygen and quality of sleep in patients with chronic obstructive lung disease JL MCKEON,K MURREE-ALLEN, NA SAUNDERS ............. . ............................................................. 184
Results of resection for bronchogenic carcinoma in patients over the age of 80 T SHIRAKUSA, M TSUTSUI, N IRIKI,K MATSUBA, T SAITO, S MINODA, T IWASAKI, N HIROTA, J KUONO ............................................. 189
Surgical treatment of hydatid cysts of the lung: report on 1055 patients R DOGAN, M YUKSEL, G SETIN, K SUZER,M ALP, S KAYA, M UNLU, B MOLDIBI ....................................................................... 192
A self management plan in the treatment of adult asthma R BEASLEY, M CUSHLEY, ST HOLGATE.................. 200Uvulopalatopharyngoplasty in severe idiopathic obstructive sleep apnoea syndrome EB WALKER, RW FRITH,
DA HARDING, BR CANT................................................................................. 205Lung function after coronary artery surgery using the internal mammary artery and the saphenous vein
SC JENKINS, SA SOUTAR, A FORSYTH, JRW KEATES, J MOXHAM................................................. 209
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Pulmonary manifestations of tuberous sclerosis in first degree relatives JM SLINGERLAND, RF GROSSMAN,D CHAMBERLAIN, CE TREMBLAY ........................................................................... 212
Etoposide compared with the combination of vincristine, doxorubicin, and cyclophosphamide in the treatment ofsmall cell lung cancer MB MCILLMURRAY, RJ BIBBY, BE TAYLOR, LP ORMEROD, JR EDGE, RJ WOLSTENHOLME,RF WILLEY, JF O REILLY, N HORSFIELD, CE JOHNSON, CP MUSTCHIN, D BRISCOE ................................. 215
Occupational asthma due to soft corrosive soldering fluxes containing zinc chloride and ammonium chlorideDC WEIR, AS ROBERTSON, S JONES, P SHERWOOD BURGE...................................................... 220
SHORT REPORTS
Minitracheotomy: a simple alternative to tracheostomy in obstructive sleep apnoea A HASAN, J MCGUIGAN,MDL MORGAN, HR MATTHEWS ............................................................................ 224
Bronchial casts associated with hilar lymphatic and pulmonary lymphoid abnormalities J WIGGINS, E SHEFFIELD,PK JEFFERY, DM GEDDES, B CORRIN ........................................................................ 226
Q fever pneumonia presenting as an eosinophilic pleural effusion PP MURPHY, SG RICHARDSON ..... ............ 228Bronchioloalveolar carcinoma presenting as a thin walled cavity in a young man PM DE JONG, DLT BUSSCHER,
WIM BAKKER............................................................................................ 230Malignant change in a benign pulmonary hamartoma A BASILE, A GREGORIS, B ANTOCI, M ROMANELLI ..... ...... 232Severe methaemoglobinaemia after flexible fibreoptic bronchoscopy RL KOTLER, J HANSEN-FLASCHEN, MP CASEY. 234Mitral prosthetic valve regurgitation due to stent fracture of a porcine bioprosthesis J AU, C CAMPANELLA ...... 236Prolonged hypoxaemia following inhalation of hydrogen chloride vapour MJ FINNEGAN, ME HODSON ..... ...... 238
CORRESPONDENCE
Predicted values: how should we use them? JE COTES; MR MILLER, AC PINCOCK ................................. 240
No. 4 APRIL
EDITORIALS
Human cytomegalovirus infection JGP SISSONS, LK BORYSIEWICZ.............................................. 241Hypoxia, almitrine, and peripheral neuropathy P HOWARD .................................................. 247
ORIGINAL ARTICLES
Ventilatory and heart rate responses to hypoxia and hypercapnia in patients with diabetes mellitus M NISHIMURA,K MIYAMOTO, A SUZUKI, H YAMAMOTO, M TSUJI, F KISHI, Y KAWAKAMI.........................................251
Ventilation-perfusion mismatching in acute severe asthma: effects of salbutamol-and 100% oxygen E BALLESTER,A REYES, J ROCA, R GUITART, PD WAGNER, R RODRIGUEZ-ROISIN ............................................. 258
Exercise responses in patients treated for pulmonary tuberculosis by thoracoplasty MS PHILLIPS, WJM KINNEAR,D SHAW, JM SHNEERSON .................................................................................. 268
Changes in day and night time oxygenation with protriptyline in patients with chronic obstructive lung diseaseF SERIES, Y CORMIER, J LA FORGE .......................................................................... 275
Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone incombination in cryptogenic fibrosing alveolitis MA JOHNSON, S KWAN, NJC SNELL, AJ NUNN, JH DARBYSHIRE,M TURNER-WARWICK ............................--............................. 280
Bronchoalveolar lavage cell analysis in patients with human immunodeficiency virus related diseases v PLAZA,P JIMtNEZ, A XAUBET, C PICADO, A TORRES, C AGUSTi, A AGUSTi-VIDAL ....................................... 289
Peripheral nerve function in patients with chronic bronchitis receiving almitrine or placebo MB ALLEN, K PROWSE 292Differential lung function in an infant with the Swyer-James syndrome A AVITAL, DL SHULMAN, E BAR-YISHAY,
N NOVISKI, J SCHACHTER, Y KRAUSZ, S GODFREY............................................................ 298
SHORT REPORTS
Clinical and radiographic study of activated carbon workers CG URAGODA ................................... 303Horner's syndrome caused by an intercostal chest drain P CAMPBELL, T NEIL, PN WAKE ..... ................... 305Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-
pyrimethamine (Fansidar) PT DANIEL, J HOLZSCHUH, PA BERG ............................................ 307Alveolitis associated with sulphamethoxypyridazine CL STEINFORT, J WIGGINS, EA SHEFFIELD, EE KEAL ..... ...... 310Supraventricular tachycardia caused by nebulised ipratropium bromide BR O'DRISCOLL ..... .................. 312
CORRESPONDENCE
Haemophilus influenzae type b infections in adults A ROUND, I MUSCAT ........................................ 313
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BOOK NOTICE................................................................................................ 313
NOTICE...................................................................................................... 313
PROCEEDINGS British Thoracic Society winter meeting 1988 .......... ........................................ 314
No. 5 MAY
EDITORIALS
Significance of antibodies to cytoplasmic components of neutrophils u SPECKS, RA DeREMEE.................... 369Cardiac sarcoidosis CM OAKLEY ............................................................................ 371
ORIGINAL ARTICLES
Antibodies to neutrophil cytoplasmic antigens in Wegener's granulomatosis and other conditions DJ HARRISON,R SIMPSON, R KHARBANDA, VE ABERNETHY, G NIMMO ....................................................... 373
Attitudes to smoking and smoking habit among the staff of a hospital PDO DAVIES, K RAJAN ..... .............. 378Respiratory function in the morbidly obese before and after weight loss PS THOMAS, ERTC OWEN, G HULANDS,
JS MILLEDGE.............................................................................................. 382Effect of low dose nebulised morphine on exercise endurance in patients with chronic lung disease IH YOUNG,
E DAVISKAS, VA KEENA.................................................................................... 387Anginal chest pain in sarcoidosis JL WAIT, A MOVAHED ........... ............................................ 391Detection of pulmonary hypertension by Doppler echocardiography of the inferior vena cava in chronic airflow
obstruction JP LAABAN, B DEEBOLD, M LAFAY, J ROCHEMAURE, P PERONNEAU................................ 396Relation of lung function and exercise capacity to mood and attitudes to health B KING, JE COTES ..... ......... 402Circadian rhythm of peak expiratory flow in asthmatic and normal children AJW HENDERSON, F CARSWELL ..... 410Longitudinal course of extrinsic allergic alveolitis in pigeon breeders SJ BOURKE, SW BANHAM, R CARTER, P LYNCH,
G BOYD................................................................................................. 415How many manoeuvres should be done to measure maximal inspiratory mouth pressure in patients with chronic
airflow obstruction? JA FIZ, JM MONTSERRAT, C PICADO, V PLAZA, A AGUSTI-VIDAL.......................... 419Adrenal function in patients with active tuberculosis DJ BARNES, S NARAQI, P TEMU, JR TURTLE.................. 422
RESEARCH OVERVIEW
Distribution of allergy in a population sample residing in Tucson, Arizona MG CLINE, B BURROWS.............. 425
SHORT REPORTS
Abnormal lung lymphatics and respiratory failure SF MOSS, DC CURRIE, EA SHEFFIELD, M BAXTER, B CORRIN,TW EVANS............................................................................................... 432
Opportunist pulmonary infection with Legionella bozemanii CR SWINBURN, FK GOULD, PA CORRIS, TL HOOPER,NJ ODOM, R FREEMAN, CGA MCGREGOR..................................................................... 434
Discrete pleural masses without effusion in a young man: an unusual presentation of tuberculosis SB BLUNT,MG HARRIES........................................................................................... 436
Primary pulmonary lymphoma in a patient with the acquired immune deficiency syndrome D POELZLEITNER,P HUEBSCH, S MAYERHOFER, A CHOTT, C ZIELINSKI.......................................................... 438
Chronic necrotising pneumonia caused by Aspergillus niger J WIGGINS, TJH CLARK, B CORRIN................... 440Pericardial actinomycosis with cardiac tamponade from a contiguous thoracic lesion AD SLUTZKER, WD CLAYPOOL 442Haemoptysis as the sole presenting symptom of dissection of the aorta AS GUIDETI, A PIK, A PEER, S SHIKIAR,
D BEN-YAAKOV.......................................................................................... 444
CORRESPONDENCE
Transfer factor for carbon monoxide in patients with diabetes mellitus with and without microangiopathy D BELL,DAW COLLIER, D WEIR, AH BARNETT, P SHERWOOD BURGE, PE JENNINGS, MS HENDY............................ 446
Does right ventricular function predict survival in patients with chronic obstructive lung disease? M KARAKUZU;W MacNEE.............................................................................................. 447
Prospective study of asthma in relation to smoking habits KM VENABLES, AJ NEWMAN TAYLOR ..... ............. 447
NOTICE ..................................................................................................... 447
BOOK NOTICES............................................................................................... 448
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No. 6 JUNE PAGE
EDITORIAL
Treatment of pulmonary disease caused by opportunist mycobacteria J BANKS................................ 449
ORIGINAL ARTICLES
Correlations between histological type, clinical behaviour, and prognosis in thymoma C RICCI, EA RENDINA,EO PESCARMONA, F VENUTA, R DI TOLLA, LP RUCO, CD BARONI............................................... 455
Effects of an external resistance on maximum flow in chronic obstructive lung disease: implications for recognitionof coincident upper airway obstruction DR ROBERTSON, CR SWINBURN, TN STONE, GJ GIBSON ..... ........... 461
The fluctuant nature of precipitating antibodies in dairy farmers Y CORMIER, i BtLANGER ..... ................. 469Repeatability of ventilatory function measurements in a population survey of 7 year old children DP STRACHAN 474Effects of posture on the distribution of pulmonary ventilation and perfusion in children and adults U BHUYAN,
AM PETERS, I GORDON, H DAVIES, P HELMS ................................................................. 480Vertical gradients of lung density in healthy supine men AB MILLAR, DM DENISON ...... ........................ 485Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to
histamine in normal subjects PN BLACK, RW FULLER, GW TAYLOR, PJ BARNES, CT DOLLERY.................. 491Malignant pleural mesothelioma in western Glasgow 1980-6 G HULKS, JSti THOMAS, E WACLAWSKI ..... ........ 496Relation between immunocytological features of bronchoalveolar lavage fluid and clinical indices in sarcoi-
dosis GM AINSLIE, LW POULTER, RM DU BOIS ............................................................. 501Radiographic measurement of total lung capacity in acute asthma MS ROTHSTEIN, MN ZELEFSKY, PQ EICHACKER,
DJ RUDOLPH, MH WILLIAMS ir .............................................................................. 510Renal and pulmonary effects of angiotensin converting enzyme inhibition in chronic hypoxic lung disease
RM OLIVER, AJ PEACOCK, JS flEMING, DG WALLER ........................................................... 513
SHORT REPORTS
Synchronous pulmonary carcinoid tumour and non-Hodgkin's lymphoma: report of two cases FM JUETTNER,C FELLBAUM, H POPPER, M LEHNERT, M NEUBAUER, W WAGNER, H BECKER ..................................... 516
Long term survival after treatment of disseminated T cell lymphoma presenting with tracheal obstruction in apatient with coeliac disease DJ SEDDON, KF CHUNG, FJ PARADINAS, ES NEWLANDS, PD SNASHALL ..... ........ 519
Non-apnoeic REM sleep induced nocturnal oxygen desaturation treated by nasal continuous positive airwaypressure F StRIS, Y CORMIER, J LA FORGE ................................................................ 521
Management of severe haemoptysis by bronchial artery embolisation in a patient with cystic fibrosis AD KING,DC CUMBERLAND, SR BRENNAN ........................................................................... 523
Pulmonary haemorrhage in Henoch-Schonlein purpura HS MARKUS, JV CLARK ...... .......................... 525
CORRESPONDENCE
Predicted values: how should we use them? DC JOHNSON; MR MILLER, AC PINCOCK.............................. 527Breathing patterns during sleep in patients with nocturnal asthma A GIANOTTI, N FRANCONIERI; AD MORGAN,
NJ DOUGLAS............................................................................................. 527
BOOK NOTICES............................................................................................... 528
NOTICE ..................................................................................................... 528
No. 7 JULY
REPORT
Trends in mortality from chronic obstructive airways disease in the United Kingdom A BACKHOUSE, WW HOLLAND 529
ORIGINAL ARTICLES
Origin and behaviour of emphysematous bullae MDL MORGAN, CW EDWARDS, J MORRIS, HR MATTHEWS .......... 533Laser light scattering spectroscopy: a new method to measure tracheobronchial mucociliary activity
K SVARTENGREN, L-G WIMAN, P THYBERG, R RIGLER ........................................................ 539
Effect of bracing on respiratory mechanics in mild idiopathic scoliosis J DECLAN KENNEDY, CF ROBERTSON,I HUDSON, PD PHELAN .......................,..... . ....................................... 548
Diagnosis of pulmonary disease in human immunodeficiency virus infection: role of transbronchial biopsy andbronchoalveolar lavage MH GRIFFITHS, G KOCJAN, RF MILLER, P GODFREY-FAUSSETT.554
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Empirical treatment without bronchoscopy for Pneumocystis carinui pneumonia in the acquired immunodeficiency PAGEsyndrome RF MILLER, AB MILLAR, IVD WELLER, SJG SEMPLE................................................ 559
Nebulised pentamidine as treatment for Pneumocystis carinii pneumonia in the acquired immunodeficiencysyndrome RF MILLER, P GODFREY-FAUSSETT, SJG SEMPLE .................................................. 565
Pulmonary cell populations in recipients of bone marrow transplants with interstitial pneumonitis HJ MILBURN,LW POULTER, HG PRENTICE, RM DU BOIS................................................................... 570
Prescription of oxygen concentrators: adherence to published guidelines JP DILWORTH, CMB HIGGS, PA JONES,RJ WITE................................................................................................ 576
Posture and nocturnal asthma KF WHYTE, NJ DOUGLAS ........... ........................................... 579Diurnal variation in serum cortisol concentrations in asthmatic subjects after allergen inhalation SR DURHAM,
J KEENAN, WOCM COOKSON, CF CRADDOCK, MK BENSON..................................................... 582Bronchial asthma at high altitude: a clinical and laboratory study in Addis Ababa B TEKLU.................... 586
PERSONAL VIEW
Studies of domiciliary oxygen in a common cause TL PETTY.................................................. 588
SHORT REPORTS
Relapse of Pneumocystis carinii pneumonia in the upper lobes during aerosol pentamidine prophylaxisRM BRADBURNE, DB ETTENSOHN, SM OPAL, FD MCCOOL ...................................................... 591
Malignant carcinoid tumour of the oesophagus AR READY, JO SOUL, J NEWMAN, HR MATTHEWS.................. 594Metastatic uterine leiomyosarcoma in association with recurrent lung abscess N SHERON, M GRIFFITHS,
NMCI JOHNSON.......................................................................................... 597Tuberculous retropharyngeal abscess producing respiratory obstruction N CARROLL, RJI BAIN, MH TSEUNG,
RHT EDWARDS ............................................................................. 599Obstructive respiratory failure in cicatricial pemphigoid CRR DE CARVALHO, MBP AMATO, LMMF DA SILVA,
CSV BARBAS, RA KAIRALLA, PHN SALDIVA .......... .................... ................................... 601Effect of hyperthyroidism on bronchial reactivity in non-asthmatic patients JA ROBERTS, AR MCLELLAN,
WD ALEXANDER, NC THOMSON............................................. ................................603Changes in serum potassium concentration in asthmatic and normal subjects during exercise M GUGGER ....... 605
CORRESPONDENCE
Bronchoalveolar lavage in talc induced lung disease P DE VUYST, P DUMORTIER, P LEOPHONTE; DB ETTENSOHN,A REDONDO, M KHAN, N KESSIMAN ........................................................................ 607
BOOK NOTICES............................................................................................... 607-8
No. 8 AUGUST
EDITORIAL
Asthma: epidemics and epidemiology DJ HENDRICK ............ ............................................. 609
ORIGINAL ARTICLES
Increase in hospital admissions for childhood asthma: trends in referral, severity, and readmissions from 1970 to1985 in a health region of the United Kingdom HR ANDERSON ........................................... 614
Recurrent accident and emergency department attendance for acute asthma in children SM O'HALLORAN, DP HEAF 620Spontaneous pneumothorax: comparison of simple drainage, talc pleurodesis, and tetracycline pleurodesis
M ALMIND, P LANGE, KAJ VISKUM ......................................................................... 627A phase II study of oral etoposide in elderly patients with small cell lung cancer EF SMIT, DN CARNEY, P HARFORD,
DT SLEIJFER, PE POSTMUS ............................................................................... 631Physiotherapy after coronary artery surgery: are breathing exercises necessary? SC JENKINS, SA SOUTAR,
JM LOUKOTA, LC JOHNSON, J MOXHAM ............ . ............................................................ 634Measurement of lung tissue mass in Pneumocystis carinji pneumonia DJ SEDDON, PD SNASHALL................. 640Lung function and bronchial reactivity in farmers M IVERSEN, R IAHL, EJ JENSEN, J KORSGAARD, T HALLAS ....... 645Role of histamine release in hypertonic saline induced bronchoconstrictioii SP O'HICKEY, NG BELCHER, PJ REES, TH
LEE.......................;.650Nedocromil sodium in adults with asthma dependent on inhaled cortidosteroids: a double blind, placebo controlled
study MF BONE, MM KUBIK, NP KEANEY, GD SUMMERS, CK CONNOLLY, P SHERWOOD BURGE, RG DENT, GW ALLAN 654Disturbance in respiratory mechanics in infants with bronchiolitis J SEIDENBERG, IB MASTERS, I HUDSON, A OLINSKY,
PDPHELAN............t::.; ...... 660
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The immunological component ofthe cellular inflammatory infiltrate in bronchiectasis JR LAPA E SILVA, JAH JONES,PJ COLE, LW POULTER ................................................................................... 668
SHORT REPORTS
Topical nasal anaesthesia for fibreoptic bronchoscopy: patients' preference for lignocaine gel AR WEBB,A WOODHEAD, HR DALTON, JA GRIGG, FJC MILLARD ....................................................... 674
Postirradiation pulmonary fibrosis complicated by aspergilloma and bronchocentric granulomatosis H MAKKER,K McCONNOCHIE, AR GIBBS ......... . ...................................................................... 676
Locally invasive pulmonary aspergillosis occurring in a gardener: an occupational hazard? JA ZUK, D KING,HD ZAKHOUR, JC DELANEY .............................................................................. 678
Use of expandable metal stents in the treatment of bronchial obstruction AK SIMONDS, JD IRVING, SW CLARKE,R DICK................................................................................................. 680
Unilateral pulmonary oedema following the removal of a giant pleural tumour DA WALLER, NR SAUNDERS ...... 682Bacteraemia following orotracheal intubation and oesophageal balloon dilatation CP HANSEN, H WESTH, K-E BROK,
R JENSEN, S BERTELSEN ................................................................................... 684
CORRESPONDENCE
Is current treatment increasing asthma mortality and morbidity? I GREGG; EA MITCHELL ..... .................. 686
BOOK NOTICES............................................................................................... 687
NOTICE ..................................................................................................... 688
No. 9 SEPTEMBER
EDITORIAL
The current state of lung transplantation J DARK, PA CORRIS ................................................. 689
ORIGINAL ARTICLES
Cellular characteristics of sputum from patients with asthma and chronic bronchitis PG GIBSON,A GIRGIS-GABARDO, MM MORRIS, S MATTOLI, JM KAY, J DOLOVICH, J DENBURG, FE HARGREAVE ..... ............. 693
Accident and emergency department attendance by asthmatic children SM O'HALLORAN, DP HEAF............... 700Pressurised aerosol deposition in the human lung with and without an "open" spacer device SP NEWMAN,
AR CLARK, N TALAEE, SW CLARKE......................................................................... 706Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone P CAMUS,
J-N LOMBARD, M PERRICHON, F PIARD, J-C GUtRIN, FB THIVOLET, L JEANNIN .................................. 711
Adverse effect of additional weight on exercise against gravity in patients with chronic obstructive airwaysdisease CR SWINBURN, BG COOPER, H MOULD, PA CORRIS, GJ GIBSON........................................ 716
Coronary artery bypass surgery: current practice in the United Kingdom GD ANGELINI, AJ BRYAN, RR WEST,AC NEWBY, IM BRECKENRIDGE ............................................................................ 721
Decreased pulmonary distensibility in fibrosing alveolitis and its relation to decreased lung volume MJ THOMPSON,HJH COLEBATCH ................. ........................................................................ 725
Bronchoalveolar lavage cell counts as a predictor of short term outcome in pulmonary sarcoidosis NM FOLEY,AP CORAL, K TUNG, BN HUDSPITH, DG JAMES, NMCI JOHNSON ................................................ 732
Infective respiratory exacerbations in young adults with cystic fibrosis: role of viruses and atypical micro-organisms ELC ONG, ME ELLIS, AK WEBB, KR NEAL, M DODD, EO CAUL, S BURGESS ............................ 739
Laryngeal resistance immediately after panting in asthmatic subjects M YANAI, T OHRUI, K SEKIZAWA, H SASAKI,T TAKISHIMA............................................................................................. 743
SHORT REPORTS
Small cell carcinoma of the oesophagus: report of three cases and review of published cases DM ECCLES, SG ALLAN,CTM SANG, MA CORNBLEET ............................................................................... 749
Treatment of oesophageal small cell carcinoma by combined chemotherapy and surgical resection: report of twocases and review of published cases SJ WALKER, A STEEL, MH CULLEN, HR MATTHEWS ..... .................. 751
Effect of corticosteroids on post-intubation tracheal stenosis J BRAIDY, G BRETON, L CLtMENT ..... ............. 753Annular lesion of the lung in sarcoidosis H TADA, R YASUMIZU, S YUASA, M SATO, Y MIZUNO ..... ................ 756Heterozygous FZ a, antitrypsin deficiency associated with severe emphysema and hepatic disease: case report and
family study CP KELLY, DNM TYRRELL, GSA MCDONALD, DB WHITEHOUSE, JS PRICHARD ..... ................. 758
Pseudo-occupational asthma KM VENABLES, AG DAVISON, K BROWNE, AJ NEWMAN TAYLOR.760
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Colopleural fistula due to strangulated Bochdalek hernia in an adult M SINHA, P GIBBONS, SC KENNEDY,HR MATTHEWS.......................................................................................... 762
BOOK NOTICES............................................................................................... 764
NOTICE ..................................................................................................... 764
CORRESPONDENCE
Attitudes to smoking and smoking habit among the staff of a hospital J COOREMAN, S PRETET; K KNOL; P BURKE;PDO DAVIES............................................................................................. 765
Minitracheotomy: a simple alternative to tracheostomy in obstructive sleep apnoea CD HANNING; MDL MORGAN,HR MATTHEWS.......................................................................................... 766
Alveolitis associated with sulphamethoxypyridazine JC PORTER, JS FRIEDLAND, F WOJNAROWSKA, JGG LEDINGHAM 766Cardiovascular and hypokalaemic effects of inhaled salbutamol, fenoterol, and isoprenaline K LARSSON,
P HJEMDAHL; J CRANE, C BURGESS, R BEASLEY .............................................................. 767Adrenal function in patients with active tuberculosis P MUSTCHIN; DJ BARNES, S NARAQI, P TEMU, JR TURTLE ..... 768
No. 10 OCTOBER
EDITORIAL
Sedation for fibreoptic bronchoscopy MP SHELLEY, P WILSON, J NORMAN ...................................... 769
New series: AIDS AND THE LUNGIntroduction DM MITCHELL, AA WOODCOCK ......................................................... 7761 AIDS, aprons, and elbow grease: preventing the nosocomial spread of human immunodeficiency virus and
associated organisms PJV HANSON, JV COLLINS .......................................................... 778
ORIGINAL ARTICLES
Long term survival after pulmonary resection for small cell carcinoma of the lung US PRASAD, AR NAYLOR,WS WALKER, D LAMB, EWJ CAMERON, PR WALBAUM ........................................................ 784
Second primary lung cancer: importance of long term follow up PC VAN BODEGOM, SjSc WAGENAAR, B CORRIN,JPA BAAK, J BERKEL, RGJRA VANDERSCHUEREN ............................................................. 788
Comparison of the Tru-cut biopsy needle with the Abrams punch for pleural biopsy DT MCLEOD, I TERNOUTH,N NKANZA.............................................................................................. 794
Treatment of adult asthma: is the diagnosis relevant? P LITTLEJOHNS, S EBRAHIM, R ANDERSON ..... ............. 797Circadian change in bronchial responsiveness and airflow obstruction in asthmatic children WMC VAN AALDEREN,
DS POSTMA, GH KOETER, K KNOL ..................................................... ......................803Contractility of papillary muscle from rats exposed to 28 days of hypoxia, hypercapnia, and hypoxia with
hypercapnia SV BAUDOUIN, NT BATEMAN ................................................................ 808Chickenpox pneumonia: an association with pregnancy TF ESMONDE, G HERDMAN, G ANDERSON ..... ........... 812Dose-response study of nebulised nedocromil sodium in exercise induced asthma MK ALBAZZAZ, MG NEALE,
KR PATEL............................................................................................... 816
SHORT REPORTS
Chronic necrotising pulmonary aspergillosis treated with itraconazole JA ELLIOTT, LJR MILNE, D CUMMING ...... 820Bronchoscopy findings in invasive pulmonary aspergillosis H VEREA-HERNANDO, MT MARTIN-EGANA,
C MONTERO-MARTINEZ, J FONTAN-BUESO ....................................................................822Bilateral recurrent haemorrhagic pleural effusion in asymptomatic chronic pancreatitis SC TEWARI, R JAYASWAL,
MS CHAUHAN, SK KAUL, VA NARAYANAN .................................................................. 824Dissemination of tumour cells from fine needle biopsy N REDWOOD, D BEGGS, WE MORGAN ..... ................ 826Palliation of malignant ascites with a Tenckhoff catheter DA LOMAS, PJW WALLIS, RA STOCKLEY ..... ........... 828Sarcoidosis in an adult with cystic fibrosis SD RETTINGER, EP TRULOCK, B MACKAY, HS AUERBACH ..... .......... 829
CORRESPONDENCE
Nebulised pentamidine as treatment for Pneumocystis carinii pneumonia in the acquired immunodeficiencysyndrome Q SUMMERS; RF MILLER ....................................................................... 831
Antibodies to neutrophil cytoplasmic antigens in Wegener's granulomatosis and other conditions GW BRADLEY;DJ HARRISON............................................................................................ 831
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BOOK NOTICES............................................................................................... 832
CORRECTION
Ventilation-perfusion mismatching in acute severe asthma: effects of salbutamol and 100% oxygen (BALLESTERet al)..................................................................................... 833
PROCEEDINGS British Thoracic Society meeting, summer 1989................................................. 834
No. II NOVEMBER
EDITORIAL
Botulism: a potentially common problem JM SHNEERSON..................................................... 901
ORIGINAL ARTICLES
Inspiratory and skeletal muscle strength and endurance and diaphragmatic activation in patients with chronicairflow limitation SZ NEWELL, DK MCKENZIE, SC GANDEVIA ............................................... 903
Respiratory muscle weakness in the Lambert-Eaton myasthenic syndrome CM LAROCHE, AK MIER, SG SPIRO,J NEWSOM-DAVIS, J MOXHAM, M GREEN .................................... 913
Pulmonary eosinophilia with and without allergic bronchopulmonary aspergillosis BJ CHAPMAN, S CAPEWELL,R GIBSON, AP GREENING, GK CROMPTON ................................................................... 919
Corticosteroid treatment and prognosis in pulmonary eosinophilia S CAPEWELL, BJ CHAPMAN, F ALEXANDER,AP GREENING, GK CROMPTON............................................................................. 925
Cardiopulmonary response to oxygen therapy in hypoxaemic chronic airflow obstruction JM HUNT, J COPLAND,CF MCDONALD, CE BARTER, PD ROCHFORD, RJ PIERCE ....................................................... 930
Nutritional state and exercise performance in patients with chronic obstructive lung disease AMWJ SCHOLS,R MOSTERT, PB SOETERS, LH GREVE, EFM WOUTERS .......................................................... 937
Effect of nebulised salbutamol on maximal exercise performance in men with mild asthma W FREEMAN, GE PACKE,RM CAYTON............................................................................................. 942
Prevalence ofasthma, atopy, and bronchial hyperreactivity in bronchiectasis: a controlled study J PANG, HS CHAN,JY SUNG ................. .............................................................................. 948
Generalised non-reactive tuberculosis: a clinicopathological study of four patients R SINGH, RC JOSHI, J CHRISTIE 952Transbronchial biopsy without fluoroscopy: a five year experience in outpatients 0 DE FENOYL, F CAPRON,
B LEBEAU, J ROCHEMAURE ................................................................................ 956
REVIEW
Diaphragmatic paresis: pathophysiology, clinical features, and investigation GJ GIBSON ..... .................. 960
AIDS AND THE LUNG
2-Antiretroviral treatment in human immunodeficiency virus disease AJ PINCHING ........................... 971
SHORT REPORTS
Cystic lung in Marfan's syndrome BK SHARMA, B TALUKDAR, R KAPOOR ....................................... 978Tracheal lipoma J RAHAMIN, CA BATES ...................................................................... 980
No. 12 DECEMBER
EDITORIAL
Missing link from Tibet D HEATH........................................................................... 981
REVIEW
Sleep apnoea and systemic hypertension JR STRADLING .......... ............................................ 984
ORIGINAL ARTICLES
Twitch pressures in the assessment of diaphragm weakness A MIER, C BROPHY, J MOXHAM, M GREEN ..... ........ 990Oxygen treatment of sleep hypoxaemia in Duchenne muscular dystrophy PEM SMITH, RHT EDWARDS, PMA
CALVERLEY ............................................................................................. 997
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Protriptyline treatment of sleep hypoxaemia in Duchenne muscular dystrophy PEM SMITH, RHT EDWARDS, PAGEPMA CALVERLEY .................. . ........................................................................ 1002
Effect of exercise and physiotherapy in aiding sputum expectoration in adults with cystic fibrosis W SALH,D BILTON, M DODD, AK WEBB.......................................................... ....................1006
Characterisation of bronchoconstrictor responses to sodium metabisulphate aerosol in atopic subjects with andwithout asthma GM NICHOL, A NIX, KF CHUNG, PJ BARNES ................................................ 1009
Changes in maximum expiratory flow-volume curve configuration after treatment with inhaled corticosteroidsJ KRAAN, ThW VANDER MARK, GH KOETER ................................................................ 1015
Effect of theophylline and enprofylline on bronchial hyperresponsiveness GH KOETER, J KRAAN, M BOORSMA,JHG JONKMAN, ThW VAN DER MARK....................................................................... 1022
Limited thoracoplasty in the management ofcomplicated pulmonary aspergillomas M AL-ZEERAH, K JEYASINGHAM 1027Prediction of microbial aetiology at admission to hospital for pneumonia from the presenting clinical features
BM FARR, DL KAISER, BDW HARRISON, CK CONNOLLY ....................................................... 1031Accuracy of inpatient oxygen administration AA JEFFREY, S RAY, NJ DOUGLAS ...... ........................... 1036
AIDS AND THE LUNG
Prevention of lung infections associated with human immunodeficiency virus infection PC HOPEWELL .... ...... 1038
SHORT REPORTS
Heterotopic brain tissue in the lung causing acute respiratory distress in an infant C FULLER, AR GIBBS .... ...... 1045Apparent response of small cell lung cancer to an extract of mistletoe and homeopathic treatment GW BRADLEY,
A CLOVER................................................................................................ 1047Total oesophageal duplication associated with dextrocardia and situs inversus HP GREWEL, JN LEVERMENT ...... 1049Treatment of late complications of plumbage by simultaneous removal of plomb and decortication A MORAN,
DE STABLEFORTH, HR MATTHEWS .......................................................................... 1051Squamous cell carcinoma of the pleura following bronchopleural fistula G PRABHAKAR, IM MITCHELL, T GUHA,
R NORTON............................................................................................. 1053Coronary artery-left ventricular fistula and multiple ventricular septal defects due to blunt chest trauma
A RENZULLI, C WREN, CJ HILTON............................. : 1055Evolution of acute chest syndrome in sickle cell trait: an ultrastructural and light microscopic study PS HASLETON,
K ORR, A WEBSTER, RAM LAWSON ......................................................................... 1057
CORRESPONDENCE
Repeatability of ventilatory function measurements in a population survey of 7 year old children N CHAN,M SILVERMAN; D STRACHAN .............................................................................. 1059
Relapse of pneumocystis pneumonia in the upper lobes during aerosol pentamidine prophylaxis MJ O'DOHERTY,SHL THOMAS, NT BATEMAN; RM BRADBURNE, DB ETTENSOHN, SM OPAL, FD MCCOOL............................. 1059
NOTICE...................................................................................................... 1060
BOOK NOTICES............................................................................................... 1005
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