thursday · — 8:15 introduction ... department of ophthalmology, university of auckland,...

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ThursdayMay 3, 2018

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Stand strong for scienceStand for strong vision science

ARVO Annual Meeting RegistrationMain Lobby7am – 2pm

ARVO 2019 —Vancouver Kickoff Reception

10:15 – 11amExhibit Hall

ARVO/Alcon Keynote SessionPrinciples of gene repair

in human embryos2:15 – 3:45pm

Kalakaua Ballroom BC

348348

8:15 – 10:15 am 501 In Galileo's Footsteps: visualizing immunity [IM, CO, RE] #5338-5342 311

502 Neuronal Health in AMD and Glaucoma: Lifestyle-based Therapies to Live Long and Prosper [GL, RE, CL, BI, LV] #5343-5348

Ballroom A

11am – 12:45pm 524 Advances in Clinical Therapeutics for Uveitis [IM] #5948-5953 301AB

525 Amblyopia [EY] #5954-5960 306AB

526 Visual psychophysics in color and complex vision [VI, VN] #5961-5967 310

527 Retinal Vascular Diseases II [RE] #5968-5974 311

528 Cornea Refractive Surgery [CO] #5975-5981 312

529 Clinical Innovations in Oncology [AP] #5982-5987 313A

530 Diseases and Protection [VN] #5988-5994 314

531 Retinal lipid and glucose metabolism in health and disease — Minisymposium [RC, BI, RE] #5995-6000

315

532 Retina III [PH] #6001-6007 316A

533 AMD Epidemiology and Treatment [CL] #6008-6013 316B

534 Cataract Surgery, epidemiology and clinical outcomes [LE] #6014-6019 316C

535 Genome: Structure, Function and Editing [BI] #6020-6026 320

536 Visual Fields, Vision Function, Psychophysics [GL] #6027-6033 Ballroom A

537 Pharmacological Interventions and Cellular Mechanisms [GL] 6034-6040 Ballrooms BC

1 – 2pm 546 Beckman-Argyros Award in Vision Research Ballrooms BC

2:15 – 3:45pm 547 ARVO/Alcon Keynote Session: Principles of gene repair in human embryos Ballrooms BC

Thursday, May 3 – Symposia, papers and lectures

Time Session Title Location

Symposia and minisymposia highlighted in boldface

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Thursday, May 3 – Posters

Time Session Title Program No. Board No.8:15 – 10am 503 Molecular mechanisms of diabetic retinopathy [BI] 5349 - 5379 A0001 - A0031

504 Gene variants and regulation of ocular genes expression in health and disease [BI] 5380 - 5422 A0032 - A0074

505 Retinal vascular diseases II (excluding diabetes) [RE] 5423 - 5460 A0092 - A0129

506 Retinal ischemia, angiogenesis and vascular remodeling [RC] 5461 - 5492 A0130 - A0161

507 Ganglion Cells: Metabolism and response to injury [RC] 5493 - 5517 A0162 - A0186

508 Animal electrophysiology [VN] 5518 - 5532 A0210 - A0224

509 AMD Epidemiology and outcomes [CL] 5533 - 5550 A0225 - A0242

510 AMD: immunobiology [IM] 5551 - 5564 A0243 - A0256

511 Conjunctival Allergic Disease [IM] 5565 - 5576 A0257 - A0268

512 Lymphoma, hemangioma, surface, orbit, and eyelid tumors [AP] 5577 - 5611 A0296 - A0330

513 Thyroid and orbital diseases [EY] 5612 - 5631 A0331 - A0350

514 Cataractogenesis and PCO [LE] 5632 - 5653 A0351 - A0372

515 Gene therapy, implants [PH] 5654 - 5674 A0373 - A0393

516 Drug and gene delivery systems [PH] 5675 - 5713 A0394 - A0432

517 Corneal Imaging and Topography [CO] 5714 - 5744 C0001 - C0031

518 Cornea Surgery; Refractive [CO] 5745 - 5781 C0032 - C0068

519 Fixational Eye Movements and Nystagmus [EY] 5782 - 5796 C0069 - C0083

520 Image Quality and Vision [VI] 5797 - 5815 C0084 - C0102

521 Animal Imaging [MOI, BI] 5816 - 5858 C0103 - C0145

522 Innovations in Imaging [MOI] 5859 - 5883 C0146 - C0170

523 Imaging: Anterior Segment [GL] 5884 - 5912 C0171 - C0199

523a Vitreoretinal Surgery: Novel Approaches [RE] 5913 - 5947 C0310 - C0344

11am – 12:45pm 538 Potpourri in genetic eye disease [GEN] 6041 - 6057 A0075 - A0091

539 Retinal diseases and aging: preclinical studies [RC, LV, VI ] 6058 - 6080 A0187 - A0209

540 Surgery and Wound Healing III [GL] 6081 - 6109 C0200 - C0228

541 Neuroprotection [GL] 6110 - 6152 C0229 - C0271

542 Medical education, training and telemedicine [CL] 6153 - 6172 C0272 - C0291

543 Trauma and Endophthalmitis [RE] 6173 - 6190 C0292 - C0309

545 Image-guided Laser Applications and Lasers in Retinal Therapy [RE] 6191 - 6202 C0345 - C0356

Poster board numbers correspond to poster location in Exhibit Hall; A = Poster Area A and C = Poster Area C.

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Thursday Symposia

8:15 am – 10:15 am

351

f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.

Room 311

Thursday, May 03, 2018 8:15 AM-10:15 AMCornea / Immunology/Microbiology / Retina

501 In Galileo’s Footsteps: visualizing immunity

Novel methods have emerged in recent years that allow clinicians and scientists to directly image immune-mediated events in patients and animals. Ranging from the rapid and safe clinical confocal microscopy of the cornea and anterior segment to intravital imaging of specific immune cell types in the brain and retina. These clinical tools and experimental approaches have been made possible by advances in imaging techniques combined a plethora of genetically modified model animal systems ranging from zebra fish to mice and primates. In addition there are now modalities of intravital microscopy, such as adaptive optics, that allow visualization of tissue and cellular detail deep within tissues that allowing clinicians and basic researchers to unravel and directly visualize dynamic mechanisms of immune mediated processes that cause loss of vision.

Moderators: Paul G. McMenamin and Richard W. Lee

— 8:15 Introduction

5338 — 8:20 In vivo confocal microscopy of immune cells in the living human cornea. Dipika V. Patel. Department of Ophthalmology, University of Auckland, Auckland, New Zealand

5339 — 8:40 In vivo and ex vivo multi-modal imaging of ocular inflammation in animal models of disease. Samantha Dando. Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia

5340 — 9:00 Real-time leukocyte trafficking in the living brain. Wolfgang Weninger. Centenary Institute, Sydney, New South Wales, Australia

5341 — 9:20 Adaptive optics imaging of leukocytes and microglia in the living mouse retina. Jesse B. Schallek1, 2. 1Flaum Eye Institute, University of Rochester, Rochester, NY; 2Ctr for Visual Science, University of Rochester, Rochester, NY *CR

5342 — 9:40 Imaging immune cell dynamics in the kidney. Michael Hickey. Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia

— 10:00 Panel Discussion

Thursday – Symposiua – 5338 – 5438

Ballroom A

Thursday, May 03, 2018 8:15 AM-10:15 AMBiochemistry/Molecular Biology / Clinical/Epidemiologic Research / Glaucoma / Low Vision / Retina

502 Neuronal Health in AMD and Glaucoma: Lifestyle-based Therapies to Live Long and Prosper

While there is much published on the correlation of the positive effects of healthy lifestyle activities on retina and brain health, clinicians seek a clear understanding of the specific mechanisms underlying these recommendations for age-related vision conditions such as glaucoma and AMD. This session will review evidence-based research that supports preventive and prescriptive lifestyle modifications, such as exercise, diet, nutritional supplements, and other factors, with an emphasis on exploring mechanisms of action. Such evidence-based research is essential to meet the current national and global imperatives to improve eye and brain health. These imperatives include those set out in the recommendations of the September 2016 National Academies of Sciences, Engineering, and Medicine (NASEM) report “Making Eye Health a Population Health Imperative: Vision for Tomorrow,” the “Healthy People 2020” program of the United States, the “Vision 2020” program of the International Agency to Prevent Blindness and the World Health Organization, and the “Vital Directions for Health and Health Care” of the National Academy of Medicine. Topics to be discussed in this symposium include the involvement of oxidative stress and mitochondria in exercise, epidemiology, and epigenetics, and the biochemistry of diet and nutritional interventions. Attending this symposium should empower participants to discuss evidence-based lifestyle modification research with fellow clinicians and researchers, patients, the public, and policymakers.

Moderators: Adriana Di Polo, David J. Calkins and Diane Bovenkamp

5343 — 8:15 Introduction: Evidence-based, interdisciplinary eye and brain research to address public health issues and public interest. Diane Bovenkamp. BrightFocus Foundation, Clarksburg, MD

5344 — 8:25 Mitochondria, exercise, diet and the aging retina. Ian A. Trounce. Center for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia

5345 — 8:45 Epidemiological evidence informing the benefit nutrients to prevent or slow glaucoma and AMD. Julie A. Mares. Ophthal and Visual Sci, Univ of Wisconsin-Madison, Madison, WI

5346 — 9:05 Genetic Interactions between Diet and Oral Supplements in Age-related Macular Degeneration. Emily Y. Chew. Epidemiology & Clinical Applications, National Eye Inst/NIH, Bethesda, MD

5347 — 9:25 Lifestyle X gene interactions in systemic and ocular health. Louis R. Pasquale. Ophthalmology, Harvard Medical School, Boston, MA *CR

5348 — 9:45 “Nature-Nurture, Behaviors, Common and Rare Genetic Variants Predict AMD”. Johanna M. Seddon. Tufts Univ School of Medicine, Boston, MA *CR

— 10:05 Panel Discussion

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The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/program-summary.

5362 — A0014 Validation of a Novel Cytokine Multiplex Assay for Vitreous Analysis in Diabetic Retinopathy. Markus Zumbansen1, S. Ong2, K. Teo3, 4, M. Ang3, 4, T. Endermann1, V. Arndt1, S. Lee3, 4, I. Yeo3, 4, E. Wong3, 4, G. Tan3, 4, A. Tan3, 4, Y. Yanagi3, 4, T. Y. Wong3, 4, N. Yawata3, 5. 1Ayoxxa Biosystems Gmbh, Cologne, Germany; 2Ayoxxa Living Health Technologies Pte. Ltd, Singapore, Singapore; 3Singapore National Eye Centre, Singapore, Singapore; 4Singapore Eye Research Institute, Singapore, Singapore; 5Fukuoka Dental College, Fukuoka, Japan *CR

5363 — A0015 Supplementation with EPA and DHA to Improve VLC-PUFA Levels in Diabetic Mice. Aruna Gorusupudi, F. Chang, P. S. Bernstein. Department of Opthalmology and Visual sciences, University of Utah, Salt Lake City, UT

5364 — A0016 Diabetic retinopathy-clinical and molecular genetic insights from a type 2 diabetes mellitus population-based cohort study.. Maria D. Pinazo-Duran1, V. Zanón-Moreno1, S. Sanz-Gonzalez1, J. J. Garcia-Medina1, J. Raga-Cervera1, M. Lopez-Galvez2, J. AREVALO3. 1Retinal Research, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain; 2Diabetic Retinopathy, Institute ophthalmobiology IOBA, Valladolid, Valladolid, Spain; 3Ophthalmology, Wilmer Institute, Baltimore, Mariland, United States of America, MD

5365 — A0017 Retinal Fatty Acid Synthase Activity is Elevated in Diabetes. Rithwick Rajagopal1, S. Zhang1, C. Oberlin1, G. Ling2, C. F. Semenkovich2. 1Ophthalmology and Visual Sciences, Washington University, Saint Louis, MO; 2Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

5366 — A0018 Insulin in the vitreous humor of patients with proliferative diabetic retinopathy. Nikhil S. Sahajpal1, S. Jain1, V. Vig2, P. Singh2, R. Singh2, H. Singh2, K. Singh3, R. Goel4, J. Yasuda5, D. Wright5, A. Chaubey6. 1Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India; 2Sardar Bahadur Dr Sohan Singh Eye Hospital, Amritsar, Punjab, India; 3Government Medical College, Amritsar, India; 4Punjabi University, Patiala, Punjab, India; 5Thermo Fisher Scientific, San Diego, CA; 6Greenwood Genetic Center, Greenwood, SC *CR

5367 — A0019 Selective PPAR alpha modulator, pemafibrate as a novel therapeutic target for diabetic retinopathy. Akira Shiono, H. Sasaki, H. Takagi. ophthalmology, St marianna university of medicine, Kawasaki, Japan *CR

5368 — A0020 The characteristics of diabetic retinopathy in ZDF type-2 diabetes rats. Akifumi Yamamoto, O. Sakai, H. Tokushige. New Drug Research Laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan *CR

Exhibit Hall A0001-A0031

Thursday, May 03, 2018 8:15 AM-10:00 AMBiochemistry/Molecular Biology

503 Molecular mechanisms of diabetic retinopathy

Moderators: Carmel Toomes and Susan Bolch

5349 — A0001 Evaluation of osteopontin in the vitreous of proliferative diabetic retinopathy. Koichi Nagura. National Defense Medical College, Tokorozawa, Japan

5350 — A0002 Long-term intermittent fasting prevents development of diabetic retinopathy and is associated with an increase in tauroursodeoxycholate (TUDCA) in db/db mice. Cristiano Pedrozo Vieira1, E. Beli2, L. Moldovan2, Y. Duan3, J. V. Busik4, M. Grant1. 1Ophthalmology, University of Alabama at Birmingham, Birmingham, AL; 2Ophthalmology, Indiana University, Indianapolis, IN; 3Cellular and Integrative Physiology, Indiana University, Indianapolis, IN; 4Ophthalmology, Michigan State University, East Lansing, MI

5351 — A0003 Alterations in Serum Protein Levels in Patients with Diabetic Retinopathy. Shruti Sharma1, 2, S. Purohit1, S. Kodeboyina1, S. Bai1, J. She1, A. Sharma1, 3. 1Center for Biotechnology and Genomic Med, Georgia Regents University, Augusta, GA; 2Department of Ophthalmology, Augusta University, Augusta, GA; 3Department of Population Health Sciences, Augusta University, Augusta, GA

5352 — A0004 Aspartame Effect on Cell Viability and VEGF Secretion on Rhesus Monkey Retinal Endothelial Cells in culture. Andrew T. Tsin1, B. Obregon2. 1Biomedical Sciences, UTRGV/SOM, Edinburg, TX; 2Biomedical Sciences, UTRGV/SOM, Edingburg, TX

5353 — A0005 Effect of glucose on cultured mouse cone photoreceptor cell viability and VEGF secretion. Cristian Mercado, A. T. Tsin. Biomedical Science, UTRGV/SOM, Edinburg, TX; Biomedical Science, UTRGV/SOM, Edinburg, TX

5354 — A0006 Foxo1 and Pten coordinate Irs2-mediated photoreceptor survival. Yue Yu1, 2, X. Dong1, S. Guo1, M. White1. 1Boston Children’s Hospital, Harvard medical school, Boston, MA; 2New England College of Optometry, Boston, MA

5355 — A0007 Dopamine Levels in the Vitreous of Diabetic and Non-Diabetic Humans. Jesse Smith1, C. Stelton3, S. Barb2, J. Yan2, B. Cribbs2, N. Jain2, S. Yeh2, G. Hubbard2, P. Iuvone2, A. Hendrick2. 1Ophthalmology, University of Colorado, Denver, CO; 2Ophthalmology, Emory University, Atlanta, GA; 3SK Retina, Sarasota, FL

5356 — A0008 Impact of the ROCK inhibitor ripasudil on distribution of claudin-5 in vascular endothelial cells in diabetic retinopathy. Mitsuru Arima1, S. Nakao1, F. Hao1, 2, M. Yamaguchi1, K. Shibata1, Y. Kaizu1, I. Wada1, S. Yoshida1, K. Sonoda1. 1Ophthalmology, Kyushu University, Fukuoka, Fukuoka, Japan; 2China Medical University, Shenyang, China *CR

5357 — A0009 The phospholipase D pathway modulates the inflammatory response of retinal pigment epithelium cells exposed to high glucose concentrations. Melina V. Mateos1, 2, P. E. Tenconi1, 2, V. Bermúdez1, G. M. Oresti1, 2, G. A. Salvador1, 2, N. M. Giusto1, 2. 1Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB)-CONICET, Bahía Blanca, Buenos Aires, Argentina; 2Depto. de Biología, Bioquímica y Farmacia (DBByF), Universidad Nacional del Sur (UNS), Bahía Blanca, Buenos Aires, Argentina

5358 — A0010 Intravitreal pro-inflammatory cytokines induce signs of diabetic retinopathy in non-obese diabetic mice. Odunayo O. Mugisho1, 2, C. R. Green2, D. Squirrell2, S. Bould2, J. Zhang2, M. Acosta3, I. D. Rupenthal1, 2. 1Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand; 2Department of Ophthalmology and the New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand; 3School of Optometry and Vision Science and the New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand *CR

5359 — A0011 Erythropoietin Protects Retinal Pigment Epithelium in Experimental Diabetic Retinopathy. Chaoyang Zhang1, H. Xie1, Y. Yang1, Q. Yang1, H. Tian1, L. Lu1, W. Li2, J. Zhang3, G. Xu1. 1Department of Ophthalmology of Shanghai Tenth People’s Hospital, and Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China; 2Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA; 3Department of Ophthalmology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

5360 — A0012 Analysis of fluid phase complement system activation in diabetic retinopathy. Jeya Maheshwari Jayapal1, R. R. Pai1, N. L. Demonte1, V. P1, B. P. Phangtey2, K. Ramasamy2, D. Kuppamuthu1. 1Department of Proteomics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India; 2Retina-Vitreous Services, Aravind Eye Hosptial, Madurai, Tamil Nadu, India

5361 — A0013 Systemic reduction of GLUT1 prevents hallmarks of diabetic retinopathy. Ivy S. Samuels1, 2, M. Tarchick1, 3, T. D. Trobenter1, 2, M. R. Kozlowski2. 1Research Service, Louis Stokes VA Medical Center, Cleveland Heights, OH; 2Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 3Biology, University of Akron, Akron, OH

5349 – 5368 – Thursday – Posters

Thursday Posters8:15 am

– 10:00 am

353


5369 — A0021 IRS-2 necessary for structural organization of the retina. Jesus Fraile Maya2, R. Romero Martín2, J. Carretero Gonzalez1, P. Cidad Betegon2. 1Anatomy and Cell Biology, University of Salamanca, Salamanca, Salamanca, Spain; 2Ophthalmology, Universitary Hospital of La Paz, Madrid, Madrid, Spain

5370 — A0022 The Effect of DR circulatory microRNAs on VEGF secretion in human retinal pigment epithelial cells. Zeljka Smit-McBride, K. N. Nguyen, A. W. Lai, G. W. Elliott, J. D. Nguyen, A. T. Nguyen, L. S. Morse. Vitreo-Retinal Research Lab, Univ of California, Davis Sch of Med, Davis, CA *CR

5371 — A0023 Distinct Roles of Wnt Co-receptors in the Regulation of Wnt Signaling in Diabetic Retinopathy. Yusuke Takahashi1, 2, H. Singh3, J. Ma3, 2. 1Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2Harold Hamm Diabetes Center, Oklahoma City, OK; 3Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK

5372 — A0024 Increased plasma galectin-1 is correlated with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy. Keitaro Hase, A. Kanda, K. Noda, S. Ishida. Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan *CR

5373 — A0025 The utility to evaluate inflammatory cytokines in the aqueous humor and aqueous flare in patients with proliferative diabetic retinopathy. Yuki Fujita, T. Sato, H. Someya, K. Takayama, Y. Karasawa, M. Takeuchi. Opthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan

5374 — A0026 Glucose-regulated protein 78 in the aqueous humor in diabetic macular edema patients. Jinwoo Kwon. Ophthalmology, St.Vincent hospital, Suwon, Kyunggi-do, Korea (the Republic of)

5375 — A0027 Serum and aqueous humor vitamin D levels in diabetic macular edema patients Section: Retina. Sung Pyo Park. Hallym University Medical Center, KangDong Sacred Heart Hospital, Seoul, Korea (the Democratic People›s Republic of)

5376 — A0028 Increased Expression of Periostin and Tenascin-C in the Aqueous Humor in Neovascular Glaucoma secondary to PDR. Keijiro Ishikawa, S. Yoshida, Y. Kubo, Y. Kobayashi, T. Nakama, Y. Murakami, Y. Ikeda, S. Nakao, K. Sonoda. Ophthalmology, Kyushu University, Fukuoka, Japan

5377 — A0029 Pinacidil Rescues Diabetes-induced Down-regulation of Kir4.1 and Aquaporin-4 in Müller cells. Hong Li1, H. Xu1, 3, J. Ma1, 2, J. Chen1, 2, S. Tang1, 2. 1Aier school of ophthalmology, ChangSha, China; 2Aier Eye Institute, ChangSha, China; 3Centre for Experimental Medicine, School of Medicine, Dentistry & Biological Sciences, Queen’s University Belfast, UK, Belfast, United Kingdom

5378 — A0030 Identification of anti-citrin antibody as a serum biomarker of diabetic retinopathy. Tatsuya Yoshitake, T. Murakami, K. Suzuma, H. Nakanishi, M. Fujimoto, Y. Dodo, M. Oishi, A. Tsujikawa. Kyoto University Graduate School of Medicine, Kyoto, Kyoto Prefecture, Japan

5379 — A0031 Microglial involvement in the neurovascular unit and alterations during early diabetic retinopathy. Andrew I. Jobling1, S. A. Mills1, J. A. Phipps1, K. A. Vessey1, M. A. Dixon1, U. Greferath1, B. V. Bui2, E. L. Fletcher1. 1Anatomy & Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia; 2Optometry and Vision sciences, The University of Melbourne, Melbourne, Victoria, Australia


Thursday, May 03, 2018 8:15 AM-10:00 AMBiochemistry/Molecular Biology

504 Gene variants and regulation of ocular genes expression in health and disease

Moderators: James E. Self and Vivek Kumar Gupta

5380 — A0032 Identification of a microRNA signature in the serum of non-infectious uveitis patients. Fleurieke H. Verhagen1, 2, C. Bekker2, M. Rossato2, S. Hiddingh2, L. de Vries3, A. Devaprasad2, A. Pandit2, J. Ossewaarde-van Norel1, N. ten Dam-van Loon1, M. Moret-Pot1, S. Imhof1, J. de Boer1, T. Radstake2, 4, J. Kuiper1, 2. 1Ophthalmology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands; 2Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands; 3Ophthalmology, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands; 4Rheuatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

5381 — A0033 MicroRNA 144 regulates Nrf2 and related antioxidant signaling in RPE. Ravirajsinh Jadeja1, F. L. Powell1, M. Thounaojam2, M. A. Jones1, M. Bartoli2, P. M. Martin1. 1Biochemistry and Molecular Biology, Augusta University, Augusta, GA; 2Ophthalmology, Augusta University, Augusta, GA

Thursday – Posters – 5369 – 5386

5382 — A0034 Long Non-coding RNA LINC00276 is involved in the differentiation of human retinal pigment epithelial cells. William Samuel, T. Duncan, O. Postnikova, C. Jaworski, R. K. Kutty, T. Redmond. LRCMB, National Eye Institute, Bethesda, MD

5383 — A0035 A homozygous mutation in the novel gene ARFGAP2 is associated with non-syndromic recessive inherited retinal degeneration (IRD). Pooja Biswas1, A. K. Chekuri1, J. Ear2, S. Borooah1, H. Matsui3, M. D’Antonio3, K. Frazer3, 4, S. Devalaraja1, S. Y. Khan5, M. A. Naeem6, S. Riazuddin6, 7, J. Akram7, 8, J. Hejtmancik9, P. Ghosh2, S. Riazuddin5, R. Ayyagari1. 1Shiley Eye Institute, University of California San Diego, La Jolla, CA; 2Departments of Medicine and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA; 3Institute for Genomic Medicine, University of California San Diego, La Jolla, CA; 4Department of Pediatrics, Division of Genome Information Sciences, Rady Children’s Hospital, La Jolla, CA; 5The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 6National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan, Pakistan; 7National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan; 8Allama Iqbal Medical College, University of Health Sciences, Lahore, Punjab, Pakistan; 9Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD

5384 — A0036&#tab; Effectiveness of near-cognate amino acid insertion for KCNJ13 nonsense suppression. Bikash R. Pattnaik1, 2, R. Ramesh4, P. K. Shahi4, 2, S. Counter4, S. Stulo4, D. M. Pillers3, 2. 1Pediatrics, Ophthalmology and Visual Sciences, Univ of Wisconsin, Madison, WI; 2McPherson Eye Research Institute, University of Wisconsin, Madison, WI; 3Pediatrics, Medical Genetics, University of Wisconsin, Madison, WI; 4Pediatrics, University of Wisconsin, Madison, WI

5385 — A0037 Genome-wide Maps of Histone Modifications in the Human Retina. Weiwei Chen1, 2, X. Chen1, 2, S. Yang1, 2, P. S. Reinach1, 2, D. Yan1, 2. 1School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; 2State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou, Zhejiang, China

5386 — A0038 Epigenomic profiling of zebrafish retinal progenitor cells during neurogenesis. Pawat Seritrakul1, 2, D. Kostka3, J. M. Gross1. 1Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 2Molecular Biosciences, University of Texas at Austin, Austin, TX; 3Developmental Biology, University of Pittsburgh, Pittsburgh, PA

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5400 — A0052 Personalized diagnosis and management of inherited pediatric ophthalmic diseases by Next-Generation Sequencing. Jinu Han1, S. Lee2, J. Choi2, J. Rim2, H. Park1, S. Han1. 1Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (the Democratic People’s Republic of); 2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

5401 — A0053 Ocular and renal phenotypes of NPHP1 deletion in Senior Loken syndrome. Ke Ning1, E. Song1, K. M. Haider2, A. Ghaffarieh2, J. A. Alvarado1, Y. Sun1, 3. 1Ophthalmology, Stanford University School of Medicine, Palo Alto, CA; 2Department of Ophthalmology,Indiana University, Indianapolis, IN; 3Palo Alto VA Medical Center, Palo Alto, CA

5402 — A0054 Long-range polymerase chain reaction validates copy number variation in autosomal dominant optic pit. Eileen Hwang1, 2, D. Morgan1, L. Owen1, J. H. Fingert3, P. S. Bernstein1, M. M. DeAngelis1. 1Moran Eye Center/University of Utah, Salt Lake City, UT; 2Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 3Ophthalmology, University of Iowa, Iowa City, IA

5403 — A0055 Functional characterization of N-terminal TIMP3 mutation underlying Sorsby fundus dystrophy in Belgian and French pedigrees. Sarah Naessens1, D. Syx1, F. Peelman2, R. Vandenbroucke3, S. De Jaegere1, F. Smeets4, J. De Zaeytijd4, B. P. Leroy4, 5, E. De Baere1, F. Coppieters1. 1Center for Medical Genetics Ghent, Ghent University, Ghent, Belgium; 2VIB-UGent Center for Medical Biotechnology, Ghent University, Ghent, Belgium; 3Inflammation Research Center, VIB, Ghent University, Ghent, Belgium; 4Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium; 5Division of Ophthalmology, The Children’s Hospital of Philadelphia, Philadelphia, PA

5404 — A0056 Leveraging consanguinity in inherited retinal diseases uncovers missing genetic variation: rare novel disease genes and a multitude of novel pathogenic variants in known disease genes. Kristof Van Schil1, S. Naessens1, S. Van de Sompele1, M. Carron1, L. Lambrechts1, N. Gruartmoner Roura1, K. Dannhausen2, F. Coppieters1, M. Karlstetter2, T. Langmann2, R. Maroofian3, A. Webster4, 5, M. Michaelides5, B. P. Leroy6, 7, E. De Baere1. 1Center for Medical Genetics Ghent, Ghent University, Ghent, Belgium; 2Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany; 3Monogenic Molecular Genetics, University of Exeter Medical School, Exeter, United Kingdom; 4UCL Institute of Ophthalmology, University College London, London, United Kingdom; 5Moorfields Eye Hospital, London, United Kingdom; 6Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium; 7Division of Ophthalmology, The Children’s Hospital of Philadelphia, Philadelphia, PA

5387 — A0039 An unusual presentation of choroideremia with macular dystrophy associated with early visual acuity loss. Georgios Kontos1, J. Kwan1, R. E. MacLaren1, 2, S. Downes1, 2. 1Oxford Eye Hospital, John Radcliffe Hospital, Oxford, England, United Kingdom; 2Nuffield Laboratory of Ophthalmology, Oxford University, Oxford, United Kingdom *CR

5388 — A0040 MicroRNAs as mediators of fibrosis in an in vitro model of proliferative vitreoretinopathy. Patricia Sanchez-Diaz1, W. Greene2, P. A. Clark1, T. A. Burke2, H. H. Wang2. 1Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX; 2Ocular Trauma, United States Army Institute of Surgical Research, San Antonio, TX

5389 — A0041 Intravitreal Injection of MicroRNA-126 Reduces the Expression of Vascular Endothelial Growth Factor and Inhibits Oxygen-Induced Retinal Neovascularization. An-Lun Wu, C. Lai, W. Wu. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, New Taipei City, Taiwan

5390 — A0042 Microglia-specific expression of Translocator Protein (18kDa). Khalid Rashid1, A. Wolf1, M. Karlstetter2, T. Langmann1. 1Ophthalmology, University of Cologne, Cologne, North Rhine Westphalia, Germany; 2BPH-DD-TRG-CIPL, Bayer AG, Cologne, North Rhine Westphalia, Germany

5391 — A0043 Characterization of ICR, MALAT1 and MEG3 lncRNA expression in human retinal endothelial cells in relation to TNFα induced ICAM-1 expression. Binoy Appukuttan1, L. M. Ashander1, A. Lumsden2, Y. Ma1, M. Z. Michael3, J. R. Smith1. 1Eye & Vision Health, Molecular Medicine and Pathology, Flinders University, Adelaide, South Australia, Australia; 2Molecular and Cellular Physiology Laboratory, Flinders University, Adelaide, South Australia, Australia; 3Gene Expression Laboratory, Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Adelaide, South Australia, Australia

5392 — A0044 Molecular Characterization of Missense Mutations in Nucleotide Binding Domains of ABCA4 Associated with Stargardt Disease. Robert S. Molday1, 2, L. Molday1. 1Biochemistry/Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada; 2Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

5393 — A0045 An Australian perspective: Genomics, molecular diagnoses and genotype-phenotype insights in the Inherited Retinal Dystrophies. Benjamin M. Nash1, 2, A. Ma1, 4, D. Wright1, 2, B. Bennetts1, 2, J. R. Grigg1, 3, R. Jamieson1, 4. 1Eye Genetics Research Unit, Children’s Medical Research Institute, Sydney Children’s Hospital Network, Westmead, New South Wales, Australia; 2Sydney Genome Diagnostics, Sydney Children’s Hospital Network - Westmead, Westmead, New South Wales, Australia; 3Save Sight Institute, Sydney, New South Wales, Australia; 4Discipline of Genetic Medicine, University of Sydney, Sydney, New South Wales, Australia

5394 — A0046 Pathogenic Mechanisms Responsible for Stargardt Disease Associated with the N965S Missense Mutation in ABCA4. Laurie L. Molday, R. S. Molday. Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

5395 — A0047 Mutation spectrum and genotype-phenotype relevancy of retinitis pigmentosa among Chinese population. Tingyu Yan, X. Zhang, R. Wei, N. Yang, Y. Ding, X. Wang, F. Liu, Y. Wang, H. Liu, J. Liu, Y. Liu, W. Sun, X. Li, J. Kong. The Ophthalmology Hospital, The 4th Afflicated Hospital of China Medical University, Shenyang, China

5396 — A0048 40 Retinitis Pigmented Families-Study on Pathogenic Mutagenesis and Molecular Diagnosis Based on Target Capture Next Generation Sequencing Technology. Xinxin Zhang, w. sun, N. Yang, T. Yan, X. Li, J. Liu, F. Liu, Y. Liu, X. Wang, H. Liu, Y. Wang, Y. Ding, R. Wei, R. Wang, J. Kong. China Medical University, ShenYang, China

5397 — A0049 CRB1 Related Retinal Degeneration with Novel Mutations. Benjamin K. Ghiam2, E. H. Wood1, A. Thanos3, S. Randhawa1. 1Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, MI; 2Oakland University, William Beaumont School of Medicine, Rochester, MI; 3Legacy Devers Eye Institute, Portland, OR

5398 — A0050 Identification Of Five Somatic Mutations In KRAS And FGFR1 Genes In Mexican Patients With Oculocutaneous Syndromes. Sofía Pérez Solórzano, Ó. Chacón-Camacho, B. Fuerte-Flores, D. López-Moreno, E. Hofmann, J. Zenteno-Ruíz. Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico

5399 — A0051 Identification of the rs121908120 polymorphism of the WNT10A gene as a risk factor for developing Keratoconus in a Mexican population sample. David Lozano-Giral1, B. Buentello2, J. C. Zenteno3. 1Integral Ophtalmology, Instituto de Oftalmologia Conde de Valenciana, CDMX, Distrito Federal, Mexico; 2Genetics, Instituto de Oftalmologia, CDMX, CDMX, Mexico; 3Genetics, Instituto de oftalmologia Conde de Valenciana, CDMX, CDMX, Mexico



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355


5405 — A0057 Genetic Association of Axial Length in Chinese Children. Li Jia Chen1, 2, S. Lu1, J. Yam1, P. Tam1, A. Young1, 2, C. Pang1. 1Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital, Hong Kong, Hong Kong

5406 — A0058 A novel mutation in the FLVCR1 gene implicated in Retinitis Pigmentosa without ataxia. Adrian Dockery1, M. Carrigan1, K. Stephenson2, N. Wynne3, G. Silvestri4, 5, D. J. Keegan2, P. F. Kenna1, 3, G. J. Farrar1. 1Genetics, Trinity College Dublin, Dublin, Ireland; 2Mater Misericordiae University Hospital, Dublin, Ireland; 3The Royal Victoria Eye and Ear Hospital, Dublin, Ireland; 4Department of Ophthalmology, The Royal Victoria Hospital, Belfast, Ireland; 5Centre for Experimental Medicine, Queen’s University Belfast, Belfast, Ireland

5407 — A0059 A rare chromosomal rearrangement in the X-linked opsin gene array is associated with retinal degeneration. Atta Ur Rehman1, Q. A. Ngo1, I. Martin-Merida2, 3, B. Garcia-Sandoval4, C. Ayuso2, 3, C. Rivolta1, 5. 1Department of Computational Biology, University of Lausanne, Lausanne, Switzerland; 2Department of Genetics, Instituto de Investigación Sanitaria–Fundación Jimenez Diaz University Hospital (IIS-FJD, UAM), Madrid, Spain; 3Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain; 4Department of Ophthalmology, Instituto de Investigación Sanitaria–Fundación Jimenez Diaz University Hospital (IIS-FJD, UAM), Madrid, Spain; 5Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom

5408 — A0060 Exome-based RetNet panel analysis in a Belgian cohort with inherited retinal disease expands the molecular and phenotypic spectrum of recently identified iRD genes. Frauke Coppieters1, S. Van de Sompele1, K. Van Schil1, c. Van Cauwenbergh1, 2, T. Rosseel1, S. De Jaegere1, T. Van Laethem1, I. Balikova2, B. P. Leroy1, 2, E. De Baere1. 1Center for Medical Genetics Ghent, Ghent University, Ghent, Belgium; 2Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium

5409 — A0061 Rare variants in the phosphoglycerate dehydrogenase (PHGDH) gene in MacTel patients lead to decreased enzymatic activity. Regis Fallon1, J. Zernant2, T. Nagasaki2, M. Gantner1, s. harkins-perry1, K. Eade1, R. Allikmets2, M. Friedlander3, 1. 1Lowy Medical Research Institute, La Jolla, CA; 2Ophthalmology, Columbia University, New York, NY; 3Molecular Medicine, The Scripps Research Institute, La Jolla, CA

5410 — A0062 Careful clinical-functional phenotyping combined with systematic, broad NGS Panel-based genotyping identify numerous novel disease-causing mutations and deletions in inherited retinal dystrophy (IRD) patients. Alessandro Iannaccone1, J. Berdia1, W. Kheir1, L. Mighion4, N. Wang3, C. DaSilva4, J. Duan3, J. J. Alexander2, 4, J. Chiang3. 1Duke Eye Center, Duke University Medical Center, Durham, NC; 2Dept. Human Genetics, Emory University, Atlanta, GA; 3Molecular Vision Laboratory, Hillsboro, OR; 4EGL Genetics, Tucker, GA *CR

5411 — A0063 Microphthalmia, coloboma and WNT signalling. Steven Eamegdool, T. Loi, A. Cheng, R. V. Jamieson. Children’s Medical Research Institute, Westmead, New South Wales, Australia

5412 — A0064 A novel genetic diagnostic approach combines NGS and RNA-seq methodologies for detection of non-coding mutations in IRD patients. Revital Bronstein1, S. Mehrotra1, E. E. Capowski2, D. M. Gamm2, E. A. Pierce1. 1Ophthalmology, Mass Eye and Ear, Boston, MA; 2 Waisman Center, University of Wisconsin-Madison, Madison, WI

5413 — A0065 Functional study of two canonical splice site variants c.3877+1G>A and c.2992_2992+6delinsTG in the EYS gene associated with recessive retinitis pigmentosa in northern Sweden. Ida Maria Westin1, 2, F. Jonsson1, L. Österman1, M. Burstedt2, M. Holmberg1, I. Golovleva1. 1Department of Medical Biosciences, Faculty of Medicine, Umeå, Sweden; 2Department of Clinical Sciences, Faculty of Medicine, Umeå, Sweden

5414 — A0066 Mutation Analysis of Japanese Patients with Leber Congenital Amaurosis by Next Generation Sequencing. Katsuhiro Hosono1, S. Nishina2, T. Yokoi2, S. Katagiri2, 3, K. Kurata1, D. Miyamichi1, K. Mizobuchi3, T. Nakano3, S. Minoshima4, M. Fukami5, H. Kondo6, M. Sato1, T. Hayashi3, N. Azuma2, Y. Hotta1. 1Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan; 2Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, Tokyo, Japan; 3Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 4Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan; 5Molecular Endocrinology, National Center for Child Health and Development, Tokyo, Japan; 6Ophthalmology, University of Occupational and Environmental Health, Fukuoka, Japan


5415 — A0067 A missense variant in CACNA1F causes variable phenotype in female carriers and hemizygous males of three unrelated Jewish families of Russian origin. Adva Kimchi1, 2, V. Meiner1, O. Elpeleg1, M. Macarov1, 2, A. Blumenfeld2, I. S. Audo3, C. Zeitz3, H. Mechoulam2, E. Banin2, D. Sharon2, C. Yahalom2. 1Department of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 2Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 3Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, Paris, France

5416 — A0068 Structural and splicing RPGRIP1 mutations in inherited retinal degenerations. Farzad Jamshidi1, E. Place1, D. Navarro-Gomez1, M. Maher1, E. Valkanas2, M. Lek2, D. MacArthur2, K. M. Bujakowska1, E. A. Pierce1. 1Ocular Genomics Institute, Mass. Eye and Ear, Boston, MA; 2Broad Institute, Boston, MA

5417 — A0069 Analysis of BEST1 mutations and clinical features in Chinese patients with multifocal vitelliform retinopathy. Xing Liu, J. Luo, H. Xiao, X. Xu, Y. Zhong, W. Wei. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China

5418 — A0070 Insights into EYS protein function(s) by deciphering the novel transcripts expressed in human dermal fibroblasts and zebrafish eye. Shimpei Takita, K. Miyamoto-Matsui, Y. Seko. Department of Rehabilitation for Sensory Functions, National Rehabilitation Center for Persons with Disabilities Research Institute, Tokorozawa, Saitama, Japan

5419 — A0071 Comprehensive molecular diagnosis of 118 Leber Congenital Amaurosis and Early Onset Severe Retinal Distrophy by targeted next generation sequencing. Fernanda B. Porto1, 2, S. A. Sampaio1, E. Jones5, F. Kok4, R. Chen5, R. T. Simoes3. 1Retina Department, INRET Clínica e Centro de Pesquisa, Belo Horizonte, Minas Gerais, Brazil; 2Retina Department, Centro Oftalmologico De Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 3Instituto De Ensino E Pesquisa Da Santa Casa Bh, Belo Horizonte, Minas Gerais, Brazil; 4Mendelics Análise Genômica, Sao Paolo, Sao Paolo, Brazil; 5Human Genome Sequencing Center Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

5420 — A0072 Genetic analysis of inherited retinal degenerative diseases with whole exome sequencing. Shigeru Sato, T. Morimoto, T. Fujikado, K. Nishida. Ophthalmology, Osaka University, Suita, Japan

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5434 — A0103 Peripheral Findings with Ultra-Widefield Fluorescein Angiography of Patients with Juxtafoveal Telangiectasis. Viren Govindaraju1, 2, S. N. Moysidis1, S. Gamsky1, 3, N. Koulisis1, P. Rao1, G. A. Williams1, 3, M. T. Trese1, 3, A. Capone1, 3. 1Associated Retinal Consultants, Royal Oak, MI; 2Central Michigan University College of Medicine, Grosse Pointe Park, MI; 3Oakland University, William Beaumont School of Medicine, Rochester, MI

5435 — A0104 Spectral-domain optical coherence tomography (SD-OCT) findings in retinal vessel occlusion – Can retinal ischemia be detected in OCT findings?. Egbert Matthe1, O. Furashova2. 1Dept of Ophthalmology, University of Dresden, Dresden, Germany; 2Klinikum Chemnitz, Chemnitz, Germany

5436 — A0105 Effect of Epiretinal Membranes on Intravitreal Dexamethasone Implant Treatment for Macular Edema Secondary to Branched Retinal Vein Occlusion: A Pilot Study. Mirinae Jang, S. Lee, J. Kim, E. Lee. Ophthalmology, Jeju National University Hospital, Jeju-si, Korea (the Republic of)

5437 — A0106 Initial Loss of Interdigitation Zone on OCT following CRVO May Predict Future Visual Acuity Improvement. Wyatt Messenger, J. I. Lim. University of Illinois at Chicago, Chicago, IL

5438 — A0107 Rabbit and Monkey Retinal GSH/GSSG Ratios as Preclinical Predictors of Toxicity from Potential Retinal Therapeutics. Corinne G. Wong, T. C. Bruice, T. W. Bruice. Sclera LLC, Carlsbad, CA

5439 — A0108 The Presence of Collateral Vessels is a Useful Prognostic Sign in Patients with Retinal Vein Occlusions. Kyle N. Kaneko1, 2, G. T. Kokame1, 2, R. Wee1, 2, S. Choi3, J. J. Chen3, J. C. Lai1, 2. 1Research, Hawaii Macula and Retina Institute, Honolulu, HI; 2Retina Consultants of Hawaii, Honolulu, HI; 3Biostatistics, University of Hawaii School of Medicine, Honolulu, HI *CR

5440 — A0109 Real world clinical audit of aflibercept and ranibizumab use in the management of macular oedema secondary to central retinal vein occlusion. Mohammed Elatfy1, 2, J. Than2, G. Palexas2. 1UCL, London, United Kingdom; 2Ophthalmic department, North Middlesex University Hospital, London, United Kingdom

5441 — A0110 Real world results of aflibercept treatment for macular oedema secondary to central retinal vein occlusions. Zaria Ali1, T. M. Aslam2, 1, C. Bailey1, R. Chhabra1, A. Stone1, Y. D’Souza1, S. Mahmood1, K. Balaskas3, 2. 1Manchester Royal Eye Hospital, Blackburn, England, United Kingdom; 2University of Manchester, Manchester, United Kingdom; 3 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom *CR

5421 — A0073 A heterozygous deletion of a noncoding part of the PRPF31 gene causes retinitis pigmentosa via reduced gene expression. Francesco Paolo Ruberto1, S. Balzano1, A. Kimchi3, P. Namburi3, T. Ben-Yosef4, E. Banin3, D. Sharon3, C. Rivolta1, 2. 1Department of Computational Biology, University of Lausanne, Lausanne, Switzerland; 2Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom; 3Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 4Genetics Department Medicine, Technion, Haifa, Israel

5422 — A0074 Sector Retinitis Pigmentosa caused by mutations of the RHO gene. Yang Li, K. Xu, T. Xiao, X. Zhang, Y. Xie. Beijing Inst of Ophthalmology, Beijing Tongren Hospital, Beijing, China


Thursday, May 03, 2018 8:15 AM-10:00 AMRetina

505 Retinal vascular diseases II (excluding diabetes)

Moderator: Robert L. Avery

5423 — A0092 Phloroglucinol suppresses inflammatory responses induced by vascular endothelial growth factor in mouse cone photoreceptor-derived cells through regulation of nuclear factor kappa B. Minsup Lee1, S. Yoon1, S. Choi1, J. Yang1, 2. 1T2B Infrastructure Center for Ocular Disease, Busan, Korea (the Democratic People’s Republic of); 2Ophthalmology, Inje University College of Medicine, Busan, Korea (the Republic of)

5424 — A0093 Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion. Andrew J. Rong, S. S. Swaminathan, E. Vanner, R. K. Parrish. Ophthalmology, Bascom Palmer Eye Institute, Miami, FL

5425 — A0094 Ultra-Wide Field Fluorescein Angiography in Sickle Cell Retinopathy: Correlations Between Peripheral Nonperfusion Area and Macular Vascular Density on Optical Coherence Tomography Angiography. Cynthia J. Kamami-Levy, A. Miere, A. Mouallem, e. bruyere, L. Debillon, A. Glacet-Bernard, O. Zambrowski, E. H. Souied. Ophthalmology, Creteil Intercommunal Hospital, Paris, Ile-De-France, France *CR

5426 — A0095 The effect of early-scatter laser photocoagulation on the formation of collateral vessels in branch retinal vein occlusion. An Seoung Hyun, W. Jeong, W. Park. Ophthalmology, Dong-A University College of Medicine, Busan, Korea (the Republic of)

5427 — A0096 Quantitative Optical Coherence Tomography Angiography Parameters in Central Retinal Vein Occlusion. Sarwar Zahid1, M. Alam2, X. Yao2, 1, J. I. Lim1. 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 2Department of Bioengineering, University of Illinois at Chicago, Chicago, IL

5428 — A0097 Arterial Stiffness and Pulse Wave Velocity Quantification in Bovine Retinal Arteries. Mahdieh Rezaeian1, A. Schulz1, A. Leloup2, M. Abbasi1, M. Golzan3, S. L. Graham1, M. Butlin4. 1Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia; 2Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium; 3Vision Science Group, University of Technology Sydney, Sydney, New South Wales, Australia; 4Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia

5429 — A0098 FK506 Prevents Retinal Neovascularization by Regulating CaN-NFATc1 Pathway. Yaguang Hu1, Y. Xu1, X. Lu1, M. Chen2, S. Yu1, C. Tsui1, J. Li1, X. Liang1. 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China; 2Department of Ophthalmology, Dongguan People’s Hospital, Dongguan, Guangdong, China

5430 — A0099 The pathophysiological roles of vascular endothelial growth factor (VEGF) on retinal edema and nonperfusion areas in retinal vein occlusion murine model. Anri Nishinaka, Y. Inoue, S. Fuma, Y. Hida, S. Nakamura, M. Shimazawa, H. Hara. Gifu Pharmaceutical University, Gifu, Japan

5431 — A0100 The increased arterial oxygen saturation in branch retinal vein occlusion depends on the size of the affected retinal area. Signe K. Jeppesen1, 2, T. Bek1, 2. 1Ophthalmology, Aarhus University Hospital, Aarhus City, Denmark; 2Aarhus University, Aarhus City, Denmark

5432 — A0101 Difference of aqueous cytokines according to distribution of ischemia assessed by ultra-widefield fluorescein angiography in macular edema secondary to retinal vein occlusion. Min Sagong1, D. Noh1, J. Lee1, N. Choi1, I. Kim1, J. Hemert2, J. Son1, Y. KIM3, S. Cha1. 1Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea (the Republic of); 2Optos PLC, Dunfermline, United Kingdom; 3Department of Ophthalmology, Catholic University of Daegu School of Medicine, Daegu, Korea (the Republic of)

5433 — A0102 Prospective evaluation of morphological and functional change after intravitreal ranibizumab therapy for macular edema secondary to branch retinal vein occlusion. Jujo Tatsuya, H. Sasaki, A. Shiono, J. Kogo, H. Takagi. St.marianna university, Kawasaki, Kanagawa, Japan *CR, f



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357


5442 — A0111 Identification of hypoxia-regulated genes in wild type and clock gene knock out mouse retinal Müller cells by RNAseq analysis. Lili Xu1, Q. Liu2, D. McMahon1. 1Biological Science, Vanderbilt University, Nashville, TN; 2Biomedical Informatics, Vanderbilt University, Nashville, TN

5443 — A0112 Effects of topical brimonidine-timolol on injection intervals in patients receiving combination therapy for retinal vein occlusions. Chelsey Krambeer1, R. Membreno2, D. Kermany3, S. Bahadorani2, K. Beck2, K. Wannamaker2, W. Tie2, R. Diaz-Rohena2, D. Nolan4, J. Sohn2, M. Singer4. 1Texas Tech University Health Science Center El Paso, San Antonio, TX; 2Long School of Medicine at University of Texas Health San Antonio, San Antonio, TX; 3University of Texas at Austin, Austin, TX; 4Medical Center Ophthalmology Associates, San Antonio, TX *CR

5444 — A0113 Cilioretinal Artery Occlusion Associated with Optic Disc Edema. Eric Weinlander, T. Wubben, M. Thomas, K. Davis, W. Cornblath, M. W. Johnson. Kellogg Eye Center, University of Michigan, Ann Arbor, MI

5445 — A0114 Intra-arterial Thrombolysis for Central Retinal Artery Occlusion. Benjamin Botsford1, A. LAHAM1, G. Bonhomme1, S. Desai2, T. G. Jovin2, A. W. Eller1. 1Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA

5446 — A0115 Longitudinal changes in choroidal thickness in branch retinal vein occlusion with and without cystoid macular edema. Jane S. Kim, A. Thomas, S. Yoon, F. Birnbaum, N. Mukherjee, K. Khan, J. Powers, M. Gomez-Caraballo, S. Fekrat. Department of Ophthalmology, Duke University Health System, Durham, NC *CR

5447 — A0116 Morphologic changes in the optic nerve head of eyes with central retinal vein occlusion treated with multiple intravitreal injections. Mohsin Ali, A. S. Thomas, S. Fekrat. Ophthalmology, Duke University, Durham, NC

5448 — A0117 Optical Coherence Tomography Angiography Findings in Retinal Vein Occlusion Treated with Anti-Vascular Endothelial Growth Factor. Eung-Suk Kim, J. Kim, S. Noh, K. Kim, K. Bae, S. Yu. Ophthalmology, Kyung Univ Medical Center, Seoul, Korea (the Democratic People›s Republic of)

5449 — A0118 Beyond two years of treatment with anti-vascular endothelial growth factor for patients with retinal vein occlusions. Annette Rasmussen1, M. Larsen1, 2, H. Lund-Andersen1, 2. 1Department of Ophthalmology, Rigshospitalet - Glostrup. Denmark, Glostrup, Denmark, Denmark; 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark *CR

5450 — A0119 Measurement of Vessel Density along the Retinal Vascular Arcades with OCT-Angiography (OCT-A) in Acute Retinal Vein Occlusion (RVO) and Correlation to Visual Acuity. Emilia Karaiskou, K. Wehrmann, N. Feucht, M. Ulbig, M. Maier. Technical University Munich, Munich, Germany *CR

5451 — A0120 Systemic and ocular associations of central retinal vein occlusion in young versus old patients. Abdulrahman ALSAEDI2, 1, H. Al-Dhibi1, A. Badawi1. 1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Ophthalmology Department, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia

5452 — A0121 Familial Retinal Arteriolar Tortuosity and Quantification of Vascular Tortuosity Using Swept-Source Optical Coherence Tomography Angiography. Steven Saraf, A. J. Tyring, C. Chen, T. Le, R. K. Wang, J. R. Chao. Ophthalmology, University of Washington, Seattle, WA

5453 — A0122 A Mouse Model of Retinal Vasculopathy with Cerebral Leukodystrophy. Bliss E. O’Bryhim1, S. Li2, C. Miner3, A. Santeford1, 4, A. Smith2, Z. You2, R. Apte1, 4, J. Miner3. 1Ophthalmology, Washington University of St. Louis, St. Louis, MO; 2Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO; 3Medicine, Washington University in St. LoSuis, St. Louis, MO; 4Developmental Biology, Washington University in St. Louis, St. Louis, MO

5454 — A0123 Management and Outcomes of Anterior Segment Neovascularization. Ananth Sastry, C. Ryu, H. Ameri. Ophthalmology, USC Roski Eye Institute, Los Angeles, CA

5455 — A0124 Assessing central retinal microcirculation changes by optical coherence tomography angiography in patients with sickle cell retinopathy. Benjamin R. Pace, C. J. Chen, M. Olsen, D. Robbins. Ophthalmology, University of Mississippi Medical Center, Ridgeland, MS *CR

5456 — A0125 Thicknesses of the central retina, retina nerve fiber layer and choroid in SCUBA divers. Tamara Vrabec1, W. R. Blodgett2, V. D. Baldassano3, b. tsai4, R. R. Peairs5. 1Geisinger Eye Institute, Danville, PA; 2Blodgett Optical, Danville, PA; 3Wyoming Seminary, Kingston, PA; 4Chung and Associates, Toronto, Ontario, Canada; 5Northeastern Eye Institute, Scranton, PA

5457 — A0126 Incidence of retinal artery occlusion following intravitreal anti-vascular endothelial growth factor injections. Xinxiao Gao1, 2, D. S. Borkar1, P. Storey1, D. Su1, A. Obeid1, K. Sioufi1, a. ho1, S. Garg1, J. Hsu1. 1Ophthalmology, Wills Eye Hospital, Philadelphia, PA; 2Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China *CR

5458 — A0127 Assessment of Quantitative Optical Coherence Tomography Angiography Parameters in Branch Retinal Vein Occlusion and Monitoring Response to Treatment. Judy L. Chen1, S. Zahid1, M. Alam2, X. Yao2, J. I. Lim1. 1Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL; 2Department of Bioengineering, University of Illinois at Chicago, Chicago, IL

5459 — A0128 The Impact and Implication of a Fovea-Involving Intraretinal Hemorrhage in Patients with Central Retinal Vein Occlusion. Mark Goerlitz-Jessen1, T. A. Mir2, A. S. Thomas1, S. P. Yoon1, S. Fekrat1. 1Ophthalmology, Duke Eye Center, Durham, NC; 2Wilmer Eye Institute, Baltimore, MD *CR

5460 — A0129 Density of the Retinal Blood Flow and Thickness Mapping by Spectralis OCT in Patients with Fabry Disease. Katerina Hufendiek1, J. Kaufeld2, I. Volkmann1, D. Brockmann1, M. Awe1, R. Kromer3, K. Hufendiek1, B. Junker1, C. Framme1. 1University Eye Hospital, Hannover Medical School, Hannover, Germany; 2Division of Nephrology, Center for Internal Medicine, Hannover Medical School, Germany, Hannover, Germany; 3Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Germany, Hannover, Germany


Thursday, May 03, 2018 8:15 AM-10:00 AMRetinal Cell Biology

506 Retinal ischemia, angiogenesis and vascular remodeling

Moderators: Erica L. Fletcher and M. Elizabeth Hartnett

5461 — A0130 VEGFR1 inhibition hinders developmental retinal vessel outgrowth in pups and reduces pathological neovascularization in OIR model in mice. Eunice Cheung, J. Cao, C. Romano. Ophthalmology, Regeneron Pharmaceuticals, Inc., Tarrytown, NY *CR

5462 — A0131 3-Hydroxypyruvate accumulates in the retina of newborn mice exposed to hyperoxia and may contribute to angiostasis. Amit Sharma, C. Singh, W. Song, Y. Bolok, J. Zhang, G. Hoppe, J. E. Sears. Cole Eye Institute, Cleveland Clinic, Cleveland, OH

5463 — A0132 Exosomes from microglia cells attenuate hypoxia-induced photoreceptor cells injury through inhibiting ER stress and decrease angiogenic growth factors through MiR155 in photoreceptor cells. Wenqin Xu, Y. Wang. Ophthalmology, Fourth Military Medical University, Xi, Shaanxi, China


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5478 — A0147 In vitro activity and ocular pharmacokinetics (PK) of SF0166, a topically administered αv integrin antagonist. Takeru Furuya, B. Askew, S. Edwards. SciFluor Life Sciences, Cambridge, MA

5479 — A0148 Metformin inhibits oxidative stress and enhances anti-oxidative signaling pathway in human retinal vascular endothelial cells. Yue Li, T. Zhou, P. A. Edwards, H. Gao, X. Qiao. Ophthalmology, Henry Ford Health System, Ferndale, MI

5480 — A0149 The role of a novel regulator of Wnt signalling in ocular angiogenesis. Xiaomeng Wang1, 2, B. Qiu2, L. Zhou3, N. Cheung4, G. Cheung4, T. Wong4, W. Hong2. 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; 2Institute of Molecular and Cell Biology, Singapore, Singapore; 3Singapore Eye Research Institute, Singaore, Singapore; 4Singapore National Eye Center, Singapore, Singapore

5481 — A0150 Endomucin (EMCN) Regulates Angiogenesis by Controlling VEGFR2 Endocytosis. Michelle LeBlanc, K. Saez-Torres, M. Saint-Geniez, Y. Ng, P. A. D’Amore. Harvard Medical School, Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Boston, MA

5482 — A0151 Analysis of VEGF expression in a chronic model of retinal neovascularization. Carl Romano, B. Iglesias, J. Cao. Ophthalmology, Regeneron Pharmaceuticals, Tarrytown, NY*CR

5483 — A0152 Persistent leaking in long term follow-up in the primate model of DL-2-aminoadipic acid-induced retinal neovascularization and vascular leakage. Wenzheng Hu, D. James, V. Woodley, C. Patel, A. Kurian, M. S. Lawrence. RxGen Inc, New Haven, CT *CR

5484 — A0153 High Efficacy and Safety of Anti-Secretogranin III therapy to treat Oxygen-Induced Retinopathy. Fen Tang1, 2, D. Liang1, W. Li2. 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center,Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Ophthalmology, Bascom Palmer Eye Institure,University of Miami, Miami, FL

5485 — A0154 Mig6 exhibits anti-angiogenic effect by modulate endothelial cell proliferation and apoptosis. Liu Lixian, R. Chen, C. Lee, X. Li. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

5486 — A0155 Differential anti-angiogenic properties of the bile acids UDCA and TUDCA in human retinal endothelial cells. Menaka Thounaojam1, D. Gutsaeva1, F. L. Powell2, P. M. Martin2, M. Bartoli1, R. Jadeja2. 1Ophthalmology, Augusta University, Augusta, GA; 2Biochemistry and Molecular Biology, Augusta University, Augusta, GA

5464 — A0133 Serine metabolism is a key pathway involved in the prevention of oxygen-induced retinopathy by Roxadustat. Charandeep Singh1, A. Sharma1, G. Hoppe1, H. Brunengraber2, J. E. Sears1. 1Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 2Department of Nutrition, Case Western Reserve University, Cleveland, OH

5465 — A0134 The effect of intravitreal injection of anti-VEGF antibody on ocular circulation in a rat model of retinopathy of prematurity. Tadashi Matsumoto1, Y. Saito2, T. Itokawa1, M. Tomita1, K. Yokoyama2, C. Yui2, T. Shiba1, H. Takahashi2, Y. Hori1. 1Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan; 2Department of Ophthalmology, School of Medicine, Showa University, Tokyo, Japan

5466 — A0135 Abnormal retinal function and vasculature in mouse neonates with hyperglycemic mother after oxygen-induced retinopathy. Kwan Wun Tsang, A. C. Lo. Ophthalmology, The University of Hong Kong, Hong Kong, Hong Kong

5467 — A0136 Endothelial Cell STAT3 Knockdown Inhibits Intravitreal Neovascularization in a Rat Model of Oxygen Induced Retinopathy. Colin A. Bretz1, E. Kunz1, T. Suwanmanee2, T. Kafri2, M. Hartnett1. 1Ophthalmology, Moran Eye Center, Salt Lake City, UT; 2Gene Therapy Center, University of North Carolina, Chapel Hill, NC

5468 — A0137 Interleukin 1 Beta prevents neovascularisation through regulation of retinal glycolysis in oxygen induced retinopathy. Senthil Selvam1, 2, A. Scott2, M. J. Radeke3, M. Fruttiger1. 1Institute of Ophthalmology, University College London, London, England, United Kingdom; 2NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, London, United Kingdom; 3Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA *CR

5469 — A0138 Knockdown of endothelial cell VEGFR2 reduces intravitreal neovascularization in the rat model of Retinopathy of Prematurity. Aaron B. Simmons1, E. Kunz1, H. Wang1, C. A. Bretz1, T. Suwanmanee2, T. Kafri2, M. Hartnett1. 1Moran Eye Center, University of Utah, Salt Lake City, UT; 2Microbiology and Immunology, University of North Carolina Gene Therapy Center, Chapel Hill, NC

5470 — A0139 Endothelial cell specific gene expression changes in Oxygen Induced Retinopathy (OIR). Alena Bartakova1, G. Weiner2, M. Oldham5, N. Ferrara4, R. Daneman3, E. Nudleman1. 1Ophthalmology, University of Californa San Diego (UCSD), La Jolla, CA; 2Medical Scientist Training Program, University of California, San Diego (UCSD), La Jolla, CA; 3Pharmacology, University of California, San Diego (UCSD), La Jolla, CA; 4Pathology, University of California, San Diego (UCSD), La Jolla, CA; 5Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, CA

5471 — A0140 Absence of Surfactant Protein A Leads To a Decrease in Retinal Vascularization in Neonatal Mice. Johannes W. Kung1, F. N. Bhatti1, 2. 1Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

5472 — A0141 Celastrol Inhibits pathological neovascularization in Oxygen-Induced Retinopathy Along with a Downregulation of HIF-1 and VEGFA Expression. Yaping Jiang1, c. Yang2, Y. Chen1. 1Yangpu District Central Hospital, Shanghai, China; 2Jiangsu Province Hospital, Nanjing, China

5473 — A0142 The dual roles of Epac1 in a mouse model of oxygen-induced retinopathy. Hua Liu1, 2, Y. Ha1, S. Zhu1, F. Xia1, 4, W. Zhang1, 3. 1Ophthalmology, University of Texas Medical Branch, Galveston, TX; 2Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX; 3Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX; 4Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

5474 — A0143 Sdc4 deficiency leads to reduced VEGFA induced pathological ocular angiogenesis. Maria Vähätupa1, G. De Rossi2, T. A. Järvinen1, 4, H. Uusitalo-Järvinen1, 3, J. R. Whiteford2. 1Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; 2William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; 3Tays Eye Centre, Tampere University Hospital, Tampere, Finland; 4Orthopedics & Traumatology, Tampere University Hospital, Tampere, Finland

5475 — A0144 Tmem30a plays critical roles in retina vascular development. Shanshan Zhang, L. Zhang, X. Zhu. University of Electronic Science and Technology of China, Chengdu, Sichuan, China

5476 — A0145 Defining a Novel Role for Complement Factor B in Diabetic Retinopathy. Hannah Murray1, 2, B. Qiu2, W. English1, G. Reilly1, X. Wang2, 3. 1The University of Sheffield, Sheffield, United Kingdom; 2Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore; 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

5477 — A0146 Proteomic analysis of Oxygen Induced Retinopathy Model using SWATH -MS proteomics reveals novel potential therapeutic target molecules. Hannele Uusitalo-Jarvinen1, 2, M. Vähätupa2, J. Nättinen2, A. Jylha2, M. Kataja1, U. Aapola2, T. Jarvinen2, 3, H. M. Uusitalo2, 1. 1Eye Centre, Tampere University Hospital, Tampere, Finland; 2 Faculty of Medicine & Life Sciences, University of Tampere, Tampere, Finland; 3Orthopaedics, Tampere University Hospital, Tampere, Finland



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5487 — A0156 1α, 25(OH)2D3 Promotes Vascular Maturation through Vitamin D Receptor Mediated VEGF Production and Attenuation of Pericyte Proliferation and Migration. Nasim Jamali1, 2, S. Wang1, S. Darjatmoko1, C. Sorenson3, 2, N. Sheibani1, 2. 1Ophthalmology and Visual Scinces, UW-Madison, Madison, WI; 2McPherson Eye Research Institute, Madison, WI; 3Pediatrics, UW-Madison, Madison, WI

5488 — A0157 lncEGFL7OS regulates human ocular angiogenesis via cis and trans regulatory mechanisms. Shusheng Wang, Q. Zhou, J. Ma, B. Yu. Cell Molecular Biology and Ophthalmology, Tulane University, New Orleans, LA

5489 — A0158 Extracellular vesicles from endothelial colony forming cells as paracrine mediators of neurovasculotrophic repair of the retina. Kyle V. Marra2, 1, S. Sakimoto2, S. Murinello2, E. Aguilar2, F. Bucher2, M. Friedlander2. 1Department of Bioengineering, University of California, San Diego, La Jolla, CA; 2Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA

5490 — A0159 Endothelial colony forming cells modulate angiogenesis by directly integrating with the choroidal vasculature. Stuart McKeown, P. Canning, S. McNutt, R. Medina, A. W. Stitt. CEM, Queen’s University Belfast, Belfast, United Kingdom

5491 — A0160 Identification of resident vasculoreparative endothelial stem cells responsible for ocular angiogenesis. Taku Wakabayashi1, 2, H. Naito2, N. Takakura2, K. Nishida1. 1Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 2Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Japan

5492 — A0161 Claudin-3 regulates hyaloid vessel formation and retinal development in zebrafish. Jing Lu, L. Lu, Y. Luo. State Key Laboratory of Ophthalmology, Zhongshan Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China


Thursday, May 03, 2018 8:15 AM-10:00 AMRetinal Cell Biology

507 Ganglion Cells: Metabolism and response to injury

Moderator: Erica L. Fletcher

5493 — A0162 Wnt-induced neurite growth in retinal ganglion cells (RGCs) is regulated by Ripk1. Adanna Udeh, G. Dvoriantchikova, T. Carmy, D. V. Ivanov, A. S. Hackam. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL

5494 — A0163 Temporal and spatial expression patterns of Rbfox1 and Rbfox2 during mouse retinal development. Lei Gu, J. Caprioli, N. Piri. Ophthalmology, University of California Los Angeles, Los Angeles, CA

5495 — A0164 Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth. Jean-Francois Bouchard1, H. Cherif1, F. Duhamel2, 3, B. Cécyre1, A. Bouchard1, A. Quintal1, S. Chemtob2, 3. 1School of Optometry, University of Montreal, Montreal, Quebec, Canada; 2Pediatrics, Research Center-CHU Sainte-Justine, Montreal, Quebec, Canada; 3Pharmacology, Université de Montréal, Montreal, Quebec, Canada

5496 — A0165 Characterization of SMI-32 positive RGC in the mouse retina. Maria Soledad S. Velasco Dalesio1, 2, I. Thompson2. 1Jersey General Hospital, St Helier, Jersey; 2School of Biomedical Sciences, King’s College London, London, United Kingdom

5497 — A0166 Characterization of Tbr2-expressing Retinal Ganglion Cells. Chai-An Mao1, C. J. Chen2, T. Kiyama1, Y. Long1, C. Whitaker1, T. C. Badea3, S. L. Mills1, S. C. Massey1. 1Ophthalmology & Visual Science, U.T. Health Science Center Houston, Houston, TX; 2Ophthalmology, Baylor College of Medicine, Houston, TX; 3NEI, Bethesda, MD

5498 — A0167 Melanopsin phototransduction is repurposed by ipRGC subtypes to shape distinct visual circuits. Tiffany M. Schmidt, T. Sonoda, S. Lee. Neurobiology, Northwestern University, Evanston, IL

5499 — A0168 Mild stress promotes neurite outgrowth of retinal explants in postnatal mice. Grace H. Chen1, C. Chiao1, 2. 1Institute of Systems NeuroscienceNational Tsing Hua University, Hsinchu City, Taiwan; 2Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

5500 — A0169 Blue light promotes neurite outgrowth of retinal explants in postnatal ChR2 mice. CHIN I LIN1, C. Chiao1, 2. 1Institute of Systems Neuroscience, National Tsing Hua University., Hsinchu, Taiwan; 2Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

5501 — A0170 Retinal ganglion cells are protected through hypothermia treatment in an organ culture model. Jose Hurst1, S. Kuehn2, A. Maliha2, F. Herms2, H. Dick2, K. Bartz-Schmidt1, S. Schnichels1, S. C. Joachim2. 1Research, Eye Hospital Tuebingen, T?bingen, Germany; 2Ophthalmology, Ruhr-University Bochum, Bochum, Germany

5502 — A0171 Regulation of retinal ganglion cell gene expression by histone methyltransferase Ezh2 requires an interaction with G9a. Jia Xie1, 2, L. WANG2, K. Batsuuri2, K. Cho2, L. Yang1, D. F. Chen2. 1Ophthalmology, Peking University First Hospital, Beijing, Beijing, China; 2Schepens Eye Research Institute, Boston, MA


5503 — A0172 Expression of sigma 2 receptors in the retina. Xuezhi Zhou1, 2, Y. Li1, J. Sahn3, S. F. Martin3, R. Wen1. 1Bascom Palmer Eye Institute, University of Miami, Miami, FL; 2Zhong Shan Opthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China; 3Department of Chemistry, University of Texas at Austin, Austin, TX *CR

5504 — A0173 Expression of the CGRP family peptides and their receptors in the rat retina. Karin Warfvinge1, 2, K. Sörensen1, L. Edvinsson1, 2, V. Fedulov1, K. Haanes1, F. Blixt2. 1Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark; 2Department of Clinical Sciences, Lund University, Lund, Sweden

5505 — A0174 Similarities in expression of CGRP/PACAP and their receptors in the rat retina. Lars Edvinsson1, 2, F. Blixt2, V. Fedulov1, K. Sörensen1, K. Haanes1, K. Warfvinge1, 2. 1Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark; 2Department of Clinical Sciences, Lund University, Lund, Sweden

5506 — A0175 The Role of Sox11 in Retinal Ganglion Cell Survival and Axon Regeneration. Ying Li1, F. Struebing1, R. King1, J. Wang1, 2, E. Geisert1. 1Emory Eye Center, Atlanta, GA; 2Tianjin Medical University General Hospital, Tianjin, China

5507 — A0176 Retinal nerve fibre layer analysis in toxic and nutritional optic neuropathy. Radhika P. Patel1, K. B. Michael1, 2. 1Ophthalmology Department, Gartnavel General Hospital, Glasgow, United Kingdom; 2Glasgow Centre for Ophthalmic Research, Gartnavel General Hospital, Glasgow, United Kingdom

5508 — A0177 3-Dimensional visualization and quantification of optic nerve degeneration after traumatic brain injury in CUBIC-cleared tissue. April Myers2, 1, C. Miranda2, 1, G. Kiri2, 1, F. Crawford2, 3, R. Tzekov2, 4. 1Neurobiology, New College of Florida, Sarasota, FL; 2Vision Research Program, The Roskamp Institute, Sarasota, FL; 3James A. Haley Veterans’ Administration Hospital, Tampa, FL; 4Ophthalmology, University of South Florida, Tampa, FL

5509 — A0178 A detailed in vivo analysis of the retinal nerve fibre layer (RNFL) in choroideremia. Dun Jack Fu2, 1, K. Xue2, 1, J. K. Jolly2, 1, R. E. MacLaren2, 1. 1Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom; 2Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom *CR

5510 — A0179 Relationship between plasma aldosterone concentration and retinal ganglion cell death. Yukari Takasago, K. Hirooka, A. Ono, M. Kobayashi, Y. Nakano. Kagawa Univ, Kitagun, Kagawa, Japan

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5525 — A0217 New device to measure behavioral vision in rodents. Marianna Bacellar-Galdino, J. A. Jamison. Ophthy-DS, Portage, MI *CR

5526 — A0218 Luminance stimulus response and Naka-Rushton parameter changes in rats following ozone exposure. Carlos A. Garcia1, 2, A. Aitsebaomo3, S. E. Smith1, J. M. Wetz1. 1Math, Science and Egineering, University of the Incarnate Word, San Antonio, TX; 2Basic Science, Rosenberg School of Optometry, San Antonio, TX; 3Basic Science, Rosenberg School of Optometry, San Antonio, TX

5527 — A0219 Changes in Visual Cues Affect Morris Water Maze Performance in Juvenile Rats. Thomas S. Vihtelic1, S. A. Colton2, E. P. Howard3, S. Denham3, R. F. Boyd1, J. T. Bartoe1. 1Ophthalmology Services, MPI Research, Mattawan, MI; 2Reproductive Toxicology, MPI Research, Mattawan, MI; 3Biostatistics, MPI Research, Mattawan, MI

5528 — A0220 Pattern Electroretinogram in Guinea Pigs: A Measure of Visual Function. Ashutosh Jnawali, K. Beach, S. Puri, O. Lisa. College of Optometry, University of Houston, Houston, TX

5529 — A0221&#tab; Temporal properties of flicker ERGs in a transgenic rabbit model of retinitis pigmentosa. Shinji Ueno1, S. Okado1, T. Kominami1, D. Inooka1, A. Nakanishi1, A. Sayo1, M. Kondo2, H. Terasaki1. 1Ophthalmology, Nagoya Univ School of Med, Nagoya, AICHI, Japan; 2Mie University Graduate School of Medicine, Tsu, Japan

5530 — A0222 Reproducibility and inter-animal variability of electroretinography measures in African green monkeys. Jordan D. Attwood, V. Woodley, C. Patel, A. Kurian, M. S. Lawrence. RX Gen, New Haven, CT *CR

5531 — A0223 Evaluation of the Relationship between Body Temperature, Oxygen Saturation and Electroretinographic Responses in Mauritius Cynomolgus Monkeys. Margaret E. Collins. Toxicology, Charles River, Reno, NV *CR

5532 — A0224 Electroretinography evaluation in the Göttingen Minipig: An alternative animal model for ocular preclinical safety assessment. Christian Li, L. Negro Silva, R. Foster, S. Authier. Study Management, CiToxLAB North America Inc., Laval, Quebec, Canada

5511 — A0180 Visual function after acoustic blast overpressure (ABO) injury: Effects of antioxidants and blast frequency. Cara Motz1, R. S. Allen1, A. Feola2, 1, D. Daszynski3, T. A. Woolman3, P. F. Kador3, S. Ramachandra Rao4, S. J. Fliesler4, 5, M. T. Pardue1, 2. 1Center for Visual and Neurocognitive Rehabilitation, Veterans Affairs Hospital - Atlanta, Atlanta, GA; 2Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 3Pharmaceutical Science, University of Nebraska Medical Center, College of Pharmacy, Omaha, NE; 4Ophthalmology, Biochemistry, & Neuroscience Program, SUNY- University at Buffalo, Buffalo, NY; 5Research Service, VA Western NY Healthcare System, Buffalo, NY

5512 — A0181 In Vivo Retinal Imaging of Post-Traumatic Neuroinflammation and Sequelae in Impact Concussion and Blast Exposure Mouse Models. Lee E. Goldstein1, 2, O. Minaeva2, 1, M. Wojnarowicz1, J. A. Moncaster1, I. Arellano3, A. M. Fisher2, 1, E. S. Franz2, 1, R. D. Ferguson4, M. Mujat4, B. R. Huber1, 5, A. B. Fulton3, 6, J. D. Akula3, 6, D. G. Hunter3, 6. 1Boston University School of Medicine, Boston, MA; 2College of Engineering, Boston University, Boston, MA; 3Ophthalmology, Boston Children’s Hospital, Boston, MA; 4Biomedical Optics, Physical Sciences, Inc, Andover, MA; 5VA Boston Healthcare System, Boston, MA; 6Ophthalmology, Harvard Medical School, Boston, MA *CR

5513 — A0182 Increased Cellularity in the Optic Nerves of Mice after Repeated Traumatic Brain Injury. Gaurav Kiri1, 2, C. Miranda1, 2, A. Myers1, 2, F. Crawford1, 4, R. T. Tzekov1, 3. 1The Roskamp Institute, Sarasota, FL; 2New College of Florida, Sarasota, FL; 3Department of Ophthalmology, University of South Florida, Tampa, FL; 4James A. Haley Veterans’ Administration Hospital, Tampa, FL

5514 — A0183 The IL-1 pathway is a key mediator of axon degeneration and vision loss in a mouse model of indirect traumatic optic neuropathy. Tonia S. Rex1, A. Bernardo-Colon1, V. Vest1, A. Clark1, B. Kim1, J. Clifton1, R. Dahl1, F. Harrison2. 1Ophthalmology & Visual Science, Vanderbilt University Medical Center, Nashville, TN; 2Endocrinology, Vanderbilt University Medical Center, Nashville, TN

5515 — A0184 Differential regulation of prokineticin 2 and its receptor in traumatic optic neuropathy. Ornella A. Oluwole1, C. Kim1, M. Thounaojam1, P. M. Martin2, D. Gutsaeva1, M. Bartoli1. 1Ophthalmology, Medical College of Georgia, Augusta, GA; 2Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA

5516 — A0185 Olfactomedin1 provides retinal ganglion cell neuroprotection and stimulates axon regeneration after optic nerve crush in rodents. Mohor B. Sengupta, C. Kole, B. Mead, N. Nakaya, S. I. Tomarev. Laboratory of Retinal Cell and Molecular Biology, Section of Retinal Ganglion Cell Biology, National Eye Institute, National Institutes of Health, Rockville, MD

5517 — A0186 Serine and glycine biosynthesis and uptake in the mouse retina. Marin Gantner1, M. Wallace2, I. Polis3, K. Eade1, R. Fallon1, M. Kitano3, C. Metallo2, M. Friedlander1, 3. 1The Lowy Medical Research Institute, La Jolla, CA; 2University of California, San Diego, La Jolla, CA; 3The Scripps Research Institute, La Jolla, CA


Thursday, May 03, 2018 8:15 AM-10:00 AMVisual Neuroscience

508 Animal electrophysiology

Moderator: Jan J. Kremers

5518 — A0210 A zebrafish thyroxin-β2-receptor gain-of-function transgenic alters the development of the ERG b-wave and the synaptic amplification of cone responses by bipolar cells. Annika Balraj1, 2, R. F. Nelson1. 1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD; 2Anatomy and Regenerative Biology, George Washington University, Washington, District of Columbia

5519 — A0211 Optic nerve crush alters the light adapted ERG of adult zebrafish. Josue Franco, A. Herrera, S. Saszik. Northeastern Illinois University, Chicago, IL

5520 — A0212 Nitric Oxide (NO) affects neuronal adaptation in the turtle retina. Reem Taha, I. Perlman. Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel

5521 — A0213 Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis. Catherine Tsilfidis1, 2, P. Lagali1, 3, U. Shanmugalingam4, P. Smith4, A. N. Baker1, 3, S. G. Coupland3, 2. 1Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 2Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada; 3University of Ottawa Eye Institute, Ottawa, Ontario, Canada; 4Neuroscience, Carleton University, Ottawa, Ontario, Canada

5522 — A0214 Human tau expression exerts beneficial effects on the mouse retinal function. Léa Rodriguez, J. Mdzomba, M. Boudreau-Laprise, S. Joly, V. Pernet. Ophthalmology, CHUL Universite Laval, Quebec, Quebec, Canada

5523 — A0215 Effects of light adaptation on mouse photopic ERG. Yichao Li, H. Qian. Visual Function Core, National Eye Institute, Bethesda, MD

5524 — A0216 Basal electroretinogram reveals slow oscillatory activity that is not altered in obese mice. Ramsés Noguez, E. Morales, A. Martínez, S. Thebault, J. ledezma. Neurobiologia Molecular y Celular, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico



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Thursday, May 03, 2018 8:15 AM-10:00 AMClinical/Epidemiologic Research

509 AMD Epidemiology and outcomes

Moderator: Jie Jin Wang

5533 — A0225 Small hard macular drusen and associations in 11-12 year-old children in the Copenhagen Child Cohort 2000 Study. Michael Larsen1, X. Q. Li1, I. C. Munch2. 1Rigshospitalet, Dept of Ophthalmology, University of Copenhagen, Glostrup, Denmark; 2Øjenafdelingen, Sjællands Universitetshospital, Roskilde, Denmark *CR

5534 — A0226 Estimation of the co-prevalence of age-related macular degeneration and glaucoma. Anh-Danh T. Phan1, E. N. Dunn1, 2, J. D. Rupp1, L. A. Myers1, L. C. Ozobu1, L. Racette1, 3. 1Ophthalmology, Indiana University / Glick Eye Institute, Indianapolis, IN; 2Ophthalmology, University of Illinois at Chicago / Illinois Eye and Ear Infirmary, Chicago, IL; 3Ophthalmology, University of Alabama at Birmingham, Birmingham, AL

5535 — A0227 Time trends in the incidence of legal blindness due to age related macular degeneration in City of Buenos Aires. Malena Daich Varela2, P. Franco2, 1, P. G. Schlottmann1, A. Suwezda3, R. E. Rosenstein4. 1Organizacion Medica de Investigacion, Buenos Aires, Argentina; 2Hospital Oftalmologico Santa Lucia, Buenos Aires, Argentina; 3Hospital de Niños “Fundacion Hospitalaria”, Buenos Aires, Argentina; 4Department of Human Biochemistry, School of Medicine/CEFyBO, Buenos Aires, Argentina *CR

5536 — A0228 Sleep Apnea Increased The Risk of Central Serous Chorioretinopathy. Pei-Kang Liu1, 2, M. Tsai3, 5, J. Hung3, K. Wu1, 4. 1Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 4Department of Ophthalmology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

5537 — A0229 Four-Year Incidence and Risk Factors of Age-Related Macular Degeneration: the ALIENOR Study. Audrey Cougnard-Gregoire1, V. Saunier1, 2, B. M. Merle1, M. Delyfer1, 2, M. B. Rougier2, P. Amouyel3, J. Lambert3, J. Dartigues1, J. Korobelnik1, 2, C. DelCourt1. 1Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team LEHA, UMR 1219, Bordeaux, F-33000, France; 2CHU de Bordeaux, Service d’Ophtalmologie, Bordeaux, F-33000, France; 3Lille University, Inserm, Lille University Hospital, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases; Labex Distalz, Lille, France *CR

5538 — A0230 Characterization of Geographic Atrophy Patients in a Large Cohort from The United States Medical Records. Felipe Conti1, 2, M. Han3, K. Wai3, W. Song4, R. P. Singh1, 3. 1Cole Eye Institute, Cleveland Heights, OH; 2Federal University of São Paulo, São Paulo, Brazil; 3Case Western Reserve University, Cleveland, OH; 4Cleveland Clinic Lerner College of Medicine, Cleveland, OH *CR

5539 — A0231 The Role of Aspirin in Age-related Macular Degeneration: the ASPREE-AMD Randomized Controlled Trial. Liubov D. Robman1, 2, R. H. Guymer2, R. Woods1, L. Hodgson2, R. Wolfe1, J. Phung1, G. Makeyeva2, Y. LePham1, K. Aung2, T. Gilbert1, J. Suleiman1, E. Maguire1, J. Lockery1, R. Trevaks1, M. Ernst3, J. McNeil1. 1Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; 2Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia; 3College of Pharmacy and Carver College of Medicine, The University of Iowa, Iowa City, IA f

5540 — A0232 Proteomic Profiles in Advanced Age-related Macular Degeneration Using an Aptamer-based Proteomic Technology. Anne M. Lynch1, 4, B. D. Wagner2, 1, S. J. Weiss3, K. M. Wall3, A. G. Palestine1, M. T. Mathias1, F. S. Siringo1, C. N. Jennifer1, J. L. Patnaik1, D. W. Drolet3, N. Janjic3, N. Mandava1. 1Ophthalmology, University of Colorado School of Medicine, Aurora, CO; 2Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO; 3SomaLogic, Inc., Boulder, CO; 4Epidemiology, Colorado School of Public Health, Aurora, CO *CR

5541 — A0233 Diacron-reactive oxygen metabolites and biological antioxidant potential tests in patients with age-related macular degeneration. Toshiyuki Matsuura, H. Kaneko, K. Takayama, H. Shimizu, T. Tsunekawa, A. Suzumura, R. Namba, H. Terasaki. Nagoya University Graduate School of Medicine, Nagoya, Japan

5542 — A0234 The relationship between lutein and zeaxanthin intake and change in macular pigment in the Second Carotenoids in Age-Related Eye Disease (CAREDS 2) study. Tom P. Lawler1, Z. Liu2, K. Christensen3, Y. Liu2, R. Wallace4, A. E. Millen5, E. Johnson6, K. Hall2, K. Gehrs7, B. A. Blodi2, J. A. Mares2, 1. 1Nutritional Sciences, University of Wisconsin - Madison, Madison, WI; 2Ophthalmology and Visual Sciences, University of Wisconsin - Madison, Madison, WI; 3Ophthalmology and Visual Sciences, University of Wisconsin - Madison, Madison, WI; 4Epidemiology, University of Iowa, Iowa City, IA; 5Epidemiology and Environmental Health, University of Buffalo, Buffalo, NY; 6Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA; 7Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA

5543 — A0235 Macular Pigment and Contrast Sensitivity Among Older Women in the Second Carotenoids in Age-Related Eye Disease Study (CAREDS2), an ancillary study of the Women’s Health Initiative. Zhe Liu1, K. Christensen1, T. P. Lawler2, K. Wood1, Y. Liu1, M. Snodderly3, A. E. Millen4, L. Tinker5, J. A. Mares1. 1Ophthalmology & Visual Science, University of Wisconsin Madison, Madison, WI; 2Nutritional Sciences, University of Wisconsin-Madison, Madison, WI; 3Department of Neuroscience and Department of Nutritional Sciences, The University of Texas, Austin, TX; 4Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY; 5Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA

5544 — A0236 Nut intake and Risk of Age-related Macular Degeneration in Women. Chung-Jung Chiu1, W. Willett2, J. H. Kang2, A. Taylor1. 1Human Nutrition Res Ctr, Tufts University, Boston, MA; 2Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

5545 — A0237 Natural history of geographic atrophy secondary to age-related macular degeneration: Proxima A data from the 1-year analysis of 100 patients. Giovanni Staurenghi1, N. Holekamp2, J. Mones3, F. Tang4, B. Tong4, R. A. Cantrell4, C. Brittain4, J. Ehrlich4, H. Lin4, C. C. Wykoff5. 1Dept of Clinical Sci (Luigi Sacco), University of Milan, Milano, Italy; 2Pepose Vision Institute, Chesterfield, MO; 3Institut de la Màcula, Barcelona, Spain; 4Genentech, Inc., South San Francisco, CA; 5Retina Consultants of Houston, Houston, TX *CR, f

5546 — A0238 Longitudinal progression of visual function metrics in early and intermediate age-related macular degeneration. Atalie C. Thompson1, S. Stinnett1, U. F. Luhmann2, V. Oza1, L. Vajzovic1, A. Horne1, C. A. Toth1, S. W. Cousins1, E. M. Lad1. 1Ophthalmology, Duke University Medical Center, Durham, NC; 2Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland *CR, f

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5560 — A0252 Chemokine receptor profiles of T cells in age-related macular degeneration. Young Joon Choi1, D. Lim2, S. Byeon1, E. Shin3, H. Chung2. 1Ophthalmology, Yonsei University, Seoul, Korea (the Republic of); 2Ophthalmology, Konkuk University, Seoul, Korea (the Republic of); 3Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea (the Republic of)

5561 — A0253 Human Retinal Pigment Epithelial (hRPE) single cell genomics of NLRP3 inflammasome is modulated by Elovanoid (ELV32-6) and NeuroprotectinD1 (NPD1) in response to Uncompensated Oxidative Stress (UOS). Aram Asatryan, M. I. Kautzmann, J. Heap, N. G. Bazan. Neuroscience, LSUHSC, New Orleans, LA *CR

5562 — A0254 Is the polarized secretion of complement factor H of importance in age-related macular degeneration? Camilla Mohlin1, S. Petrus-Reurer2, 3, F. Lanner3, k. sandholm1, P. Nilsson1, 4, B. Nilsson5, K. N. Ekdahl1, 5. 1Chemistry and Biomedicin, Linnæus Center of Biomaterials Chemistry, Linnæus University, Kalmar, Sweden; 2Department of Clinical Neuroscience, Section for Ophthalmology and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden; 3Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden and Division of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden; 4Department of Immunology, University of Oslo, Oslo, Norway; 5Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

5563 — A0255 Classical pathway complement activation contributes to photoreceptor degeneration. Kenneth J. Katschke1, H. Xi1, C. Cox1, T. Truong1, Y. Malato1, J. Elstrott2, J. Tao3, L. Diehl3, M. Van Lookeren Campagne1. 1Immunology, Genentech, South San Francisco, CA; 2Neuroscience, Genentech, South San Francisco, CA; 3Pathology, Genentech, South San Francisco, CA *CR

5564 — A0256 Association of Age-related Macular Degeneration with Retinal Vascular Caliber in Patients with the Acquired Immunodeficiency Syndrome. Douglas A. Jabs1, 2, M. L. Van Natta2, J. W. Pak3, R. P. Danis3, P. Hunt4. 1Icahn School of Medicine at Mount Sinai, New York, NY; 2Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; 3University of Wisconsin School of Medicine and Public Health, Madison, WI; 4University of California, San Francisco School of Medicine, San Francisco, CA

5547 — A0239 Wet Age-Related Macular Degeneration in Asian Americans and non-Asians: An Analysis of Comparative Outcomes. Caleb Ng1, S. Kim1, 2, M. M. Lai2. 1Ophthalmology, Loma Linda University, Loma Linda, CA; 2Ophthalmology, Georgetown University, Washington D.C., District of Columbia

5548 — A0240 Clinical Course and Outcomes of Drusenoid Pigment Epithelial Detachment in Age-Related Macular Degeneration in AREDS2. Jeannette J. Yu1, E. Agron1, C. A. Cukras1, T. E. Clemons2, E. Y. Chew1. 1Clinical Trials Branch, Division of Epidemiology and Clinical Application, National Eye Institute, Bethesda, MD; 2The Emmes Corporation, Rockville, MD

5549 — A0241 Macular function in Early and Intermediate Age-related Macular Degeneration (AMD): effect of systemic risk factors. Angelo M. Minnella, B. Falsini, m. piccardi. Ophthalmology, Università Cattolica S. Cuore Fondazione Policlinico A. Gemelli, Rome, Italy

5550 — A0242 Ethnic differences in presenting characteristics and visual acuity outcomes of neovascular age-related macular degeneration within an urban tertiary ophthalmic hospital. Farid Afshar1, S. Wagner1, K. Fasler1, R. Chopra1, K. U. Kortuem3, N. Pontikos1, T. Ramakrishnan1, G. C. Preston1, K. Balaskas1, 2, A. Tufail1, P. Patel1, P. Keane1. 1NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom; 2University of Manchester, London, United Kingdom; 3University Eye Hospital Munich, Munich, Germany *CR


Thursday, May 03, 2018 8:15 AM-10:00 AMImmunology/Microbiology

510 AMD: immunobiology

Moderator: Gerard A. Lutty

5551 — A0243 Inflammatory monocytes but not microglia contribute to light-induced retinal degeneration. Hongkang Xi1, T. Truong1, J. Elstrott2, J. Tao3, M. Dohse3, R. Arceo3, L. Diehl3, A. Sene1, M. Van Lookeren Campagne1. 1Immunology, Genentech Inc, South San Francisco, CA; 2Biomedical Imaging, Genentech Inc, South San Francisco, CA; 3Pathology, Genentech Inc, South San Francisco, CA *CR

5552 — A0244 Complement C3a Induces Macrophage to Myofibroblast Transition (MMT) in Sub-retinal Fibrosis Secondary to Neovascular Age-Related Macular Degeneration. Karis Little, M. Chen, H. Xu. Queen›s University Belfast, Belfast, United Kingdom

5553 — A0245 Angiotensin II favors subretinal inflammation in a splenic-dependent manner in acute and chronic mouse model of AMD. Christophe Roubeix1, 2, S. Augustin1, N. Reichhart3, F. Béguier1, X. P. Guillonneau1, O. Strauss3, 2, F. Sennlaub1, 2. 1Institut de la Vision, UMRS 968, UPMC, Paris, France, Paris, France; 2Berlin Institute of Health (BIH), Berlin, Germany; 3Department of ophtalmology, Charité University Medicine, Berlin, Germany

5554 — A0246&#tab; Cytokine profiles of aqueous humor in patients with neovascular age-related macular degeneration by cluster analysis. Tomohito Sato1, M. Takeuchi1, Y. Karasawa1, M. Ito2, T. Enoki3. 1Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Japan; 3Enoki Eye Clinic, Sayama, Japan

5555 — A0247 Modulation of mast cells regulates retinal microenvironment and vascular integrity. Sofia Theodoropoulou, D. A. Copland, J. Liu, L. Scott, J. Wu, A. D. Dick. Academic Unit of Ophthalmology, Bristol Medical School, Bristol, United Kingdom

5556 — A0248 Photoreceptors Constitutively Express A Variety of Complement Components. Jian Liu1, K. Harkin2, C. Luo1, J. Chen1, S. Tang1, M. Chen2, H. Xu1, 2. 1Aier Eye Institute, ChangSha, HuNan, China; 2Queen’s University Belfast, Centre for Experimental Medicine, School of Medicine, Dentistry & Biological Sciences, Belfast, United Kingdom

5557 — A0249 Long-term Low-dose Aspirin Exacerbates Laser-induced Choroidal Neovascularization Through Down-regulating Thrombospondin-1 Expression. Chang Luo1, M. Chen2, R. G. Penalva2, J. Zhao2, J. Chen1, S. Tang1, H. Xu1, 2. 1Aier Eye Institute, Aier Eye Hospital Group, Changsha, Hunan, China; 2Centre for Experimental Medicine, School of Medicine, Dentistry & Biological Sciences, Queen’s University Belfast, Belfast, United Kingdom

5558 — A0250 Role of macrophage microRNA-150 in age-related macular degeneration. Jonathan Lin1, H. V. Moolani1, A. Sene1, R. Sidhu2, J. B. Lin1, Z. Dong1, N. Ban1, D. S. Ory2, R. Apte1, 2. 1Ophthalmology & Visual Sciences, Washington University School of Medicine, Saint Louis, MO; 2Medicine, Washington University School of Medicine, Saint Louis, MO

5559 — A0251 Systemic inflammation in a collagen-induced arthritis mouse model of rheumatoid arthritis leads to attenuated laser-induced choroidal neovascularization. Gloriane Schnabolk1, E. Obert1, N. K. Banda2, B. Rohrer1, 3. 1Department of Ophthalmology, Medical University of South Carolina, Charleston, SC; 2Division of Rheumatology, University of Colorad Anschutz Medical Campus, Aurora, CO; 3Division of Research, Ralph H. Johnson VA Medical Center, Charleston, SC



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Thursday, May 03, 2018 8:15 AM-10:00 AMImmunology/Microbiology

511 Conjunctival Allergic Disease

Moderator: Akira Matsuda

5565 — A0257 Conjunctival Injection Reduction in Patients with Atopic Keratoconjunctivitis After Administration of Enteric-Coated Lactoferrin. Hiroshi Fujishima1, K. Fukagawa3, H. Yazu2, E. Shimizu2, N. Okada1. 1Ophthalmology, Tsurumi Univ School of Dental Med, Yokohama, Kanagawa, Japan; 2Ophthalmology, Keio University School of medicine, Tokyo, Japan; 3Ophthalmology, Ryogoku eye clinic, Tokyo, Japan *CR, f

5566 — A0258 The efficacy of 0.1% Tacrolimus Ophthalmic Suspension in the Treatment of Atopic Keratoconjunctivitis: A one year follow-up study. Hiroyuki Yazu1, 2, E. Shimizu1, N. Nakayama1, M. Dogru1, N. Okada3, K. Fukagawa1, 4, H. Fujishima3. 1Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 2Ophthalmology, Hino Municipal Hospital, Tokyo, Japan; 3Ophthalmology, Tsurumi University Dental Hospital, Kanagawa, Japan; 4Ryogoku Eye Clinic, Tokyo, Japan *CR

5567 — A0259 Development of a RNAi therapeutic for the treatment of allergic conjunctivitis. Victoria Gonzalez, C. Paneda, T. Martinez, A. Guerra, S. Monteiro, B. Vargas, A. Bleau, V. Ruz, A. Jimenez. Sylentis, Madrid, Madrid, Spain *CR

5568 — A0260 Preclinical Assessment of the Syk Inhibitor PRT2761 for Allergic Conjunctivitis. Andy Whitlock1, L. Belen1, M. J. Chapin2, P. J. Gomes3, M. Birrell4, A. Pandey4, D. Hollander2. 1Pre-Clinical, Ora, Andover, MA; 2Ora, Inc, Andover, MA; 3Allergy, Ora, Inc, Andover, MA; 4Portola Pharmaceuticals, South San Francisco, CA *CR

5569 — A0261 PR013, a novel therapy for Allergic Conjunctivitis and Dry Eye, demonstrates significant anti-inflammatory activity in vitro and is well tolerated in repeat dose toxicity studies. Cary Schockemoehl, M. Sampson, E. Solomon, C. Peters. Realm Therapeutics, Malvern, PA *CR

5570 — A0262 Fungus-specific IgG in patients with allergic conjunctivitis. Tatsuya Mimura, E. Watanabe, A. Mizota. Ophthalmology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan f

5571 — A0263 A Randomized, Multi-Center, Double-Masked, Vehicle-Controlled, Parallel-Group Phase 2b Allergic Conjunctivitis Clinical Trial of Topical Ocular ADX-102, a Novel Aldehyde Sequestering Agent. Paul J. Gomes2, T. Brady1, D. Hollander2, D. Clark1. 1Aldeyra Therapeutics, Lexington, MA; 2Ora, Inc., Andover, MA *CR, f

5572 — A0264&#tab; Topical Cyclosporine A 1 mg/mL Cationic Emulsion Yields Improvements in Signs of Active Severe Vernal Keratoconjunctivitis (VKC) in Pediatric Patients: Results of the Phase III VEKTIS Study. Serge Doan1, A. Leonardi2, M. Amrane3, D. Ismail3, J. Montero4, P. Aragona5, J. Nemeth6, D. Brémond-Gignac7. 1Bichat Hospital and Foundation A. de Rothschild, Paris, France; 2Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy; 3Santen SAS, Evry, France; 4Universidad de Sevilla, Sevilla, Spain; 5Dipartmento de Scienze Biomediche, Universitá di Messina, Messina, Italy; 6Department of Ophthalmology, Semmelweis University, Budapest, Hungary; 7University Hospital Necker Enfants Maladies, APHP, and Paris Descartes University, Paris, France *CR, f

5573 — A0265 The role of ILC2 in mouse models of papain-induced conjunctivitis with lacrimal grand excision. Yosuke Asada1, 2, A. Matsuda1, S. Nakae3. 1Ophthalmology, Juntendo University School of Medicine, Tokyo, TOKYO, Japan; 2Opthalmology, Tobu Chiiki Hospital, Tokyo, Japan; 3Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

5574 — A0266 Control of mouse allergic conjunctivitis by resolvins. Satoshi Iwamoto, T. Yokomizo, A. Murakami, A. Matsuda. Juntendo Univ School of Med, Chiyodaku, TOKYO, Japan

5575 — A0267 Dietary omega-3 fatty acids alleviate allergic conjunctivitis in a mouse model. Toshiaki Hirakata1, 2, H. Lee2, M. Ohba2, T. Okuno2, A. Murakami1, A. Matsuda1, T. Yokomizo2. 1Ophthalmology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan; 2Biochemistry, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan *CR

5576 — A0268 Role of Antigen-presenting Cells within Conjunctiva-associated Lymphoid Tissue in the Induction of Ocular Allergy. Philipp Steven1, 2, S. Schwab1, 3, D. R. Saban5, J. Y. Niederkorn4, U. Gehlsen1, 2. 1Ophthalmology, University of Cologne, Cologne, Germany; 2Cluster of Excellence: Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne, Germany; 3Institute of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms University Bonn, Bonn, Germany; 4Ophthalmology, University of Texas Southwestern, Dallas, TX; 5Ophthalmology, Immunology, Duke University School of Medicine, Durham, NC



Thursday, May 03, 2018 8:15 AM-10:00 AMAnatomy and Pathology/Oncology

512 Lymphoma, hemangioma, surface, orbit, and eyelid tumors

Moderators: Martine J. Jager and Hakan Demirci

5577 — A0296 Relapse of Leukemia in the Anterior Segment of the Eye: A systematic review. Thomas B. Gillette2, A. Stacey1. 1Ophthalmology, University of Washington, Seattle, WA; 2Ophthalmology, Seattle Children’s Hospital, Seattle, WA

5578 — A0297 Clinical spectrum of vitreoretinal lymphoma and its association with MyD88 L265P mutation. Ester Carreno1, T. Clench2, L. R. Steeples1, S. Salvatore1, R. W. Lee1, A. D. Dick1, J. Pawade3. 1Bristol Eye Hospital, Bristol, England, United Kingdom; 2Bristol Royal Infirmary, Bristol, United Kingdom; 3Severn Pathology Services, Bristol, United Kingdom

5579 — A0298 Sensitivity of four diagnostic tests using vitreous samples for diagnosing intraocular lymphoma. Rie Tanaka1, T. Kaburaki1, A. Karakawa1, K. Taoka2, J. Matsuda3, H. Tsuji4, A. Yoshida4, M. Takamoto1, Y. Fujino1. 1Ophthalmology, The University of Tokyo Hospital, Tokyo City, Japan; 2Haematology and Oncology, The University of Tokyo Hospital, Tokyo, Japan; 3Ophthalmology, Nerima Hikarigaoka Hospital, Tokyo, Japan; 4Ophthalmology, The Cancer Institute Hospital Of JFCR, Tokyo, Japan

5580 — A0299 Systemic therapy for vitreo-retinal lymphoma: a single-center experience. Bertil Damato1, G. Bever1, J. Kim1, A. Afshar1, J. Rubenstein2. 1Ophthamology, University of California San Francisco, San Francisco, CA; 2Hemato-Oncology, University of California, San Francisco, San Francisco, CA

5581 — A0300 Optical Coherence Tomography Findings in Primary Central Nervous System Lymphoma with or without Ocular Involvement. Arash Maleki1, 2, M. Hassan1, M. Halim1, R. Afridi1, N. V. Nguyen1, 3, Y. Sepah1. 1Byers Eye Institute, Palo Alto, CA; 2Noor Eye Hospital, Tehran, Iran (the Islamic Republic of); 3Ocular Imaging and Reading Center, Menlo Park, CA

5582 — A0301 Clinical features of primary vitreoretinal lymphomas with lesions involving organs other than central nervous system. Makoto Imazeki, Y. Usui, K. Tsubota, K. Umazume, R. Nemoto, H. Goto. Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan

5583 — A0302 Analysis of clinical features of primary vitreoretinal lymphoma followed for over 5 years. Kinya Tsubota, Y. Usui, K. Umazume, R. Nemoto, M. Shibata, H. Goto. Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan

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5598 — A0317 Extending far and wide: The role of biopsy and staging in the management of ocular surface squamous neoplasia (OSSN). Christine Greer, A. A. Polski, J. L. Berry. Ophthalmology, University of Southern California Roski Eye Institute, Pasadena, CA

5599 — A0318 Refractory follicular conjunctival lesions: overlook as just inflammation or not?. Su Kyung Jung1, s. Kim2, W. Cho3, J. Paik2, S. Yang2. 1national cancer center, Korea, Go yang, Korea (the Republic of); 2Seoul St.Mary’s hospital, Seoul, Korea (the Republic of); 3Daejeon St.Mary’s hospital, Daejeon, Korea (the Republic of)

5600 — A0319 Cavernous Hemangioma of the Conjunctiva: A Case Series of 4 Patients. Prashanth Iyer1, L. A. Dalvin2, E. B. Elimimian2, s. lally2, C. L. Shields2. 1Ophthalmology, Drexel University, Philadelphia, PA; 2Ocular Oncology, Wills Eye Hospital, Philadelphia, PA

5601 — A0320 Eyelid Tumors: A 13-year Survey from a Tertiary Hospital in Japan. Hiroto Obata2, M. Watanabe1, Y. Arai1, H. Kawashima1. 1Department of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, Japan; 2Department of Ophthalmology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

5602 — A0321 Treatment of Eyelid Squamous Cell Carcinoma and Papilloma with Interferon Alpha-2b. Elizabeth B. Elimimian1, M. Marous1, M. Casey1, L. A. Dalvin1, 2, s. lally1, C. L. Shields1. 1Ocular Oncology, Wills Eye Hospital, Philadelphia, PA; 2Mayo Clinic, Rochester, MN

5603 — A0322 The transcription factor SREBP-1 as a novel marker for sebaceous cell carcinoma of the eyelid. Paulina Garcia de Alba Graue1, A. T. Dias2, D. Miyamoto2, C. Mastromonaco2, P. R. Bustamante2, M. MacDonald2, J. V. Burnier2, M. N. Burnier2. 1Universidad Nacional Autonoma de Mexico, Mexico city, Mexico; 2Ocular Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada

5604 — A0323 Clinicopathological Correlation of Merkel Cell Carcinoma of the Eyelid. Xiao Yi Zhou1, 2, P. Monsalve1, 2, Y. Lopez3, G. W. Elgart4, S. R. Dubovy1, 2. 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Florida Lions Ocular Pathology Laboratory, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 3Universidad Iberoamericana, Santo Domingo, Dominican Republic; 4Department of Dermatology, University of Miami Miller School of Medicine, Miami, FL

5584 — A0303 Novel characterization of orbital precursor B-cell Lymphoblastic Lymphoma. Rasmus Ejstrup1, L. H. Mikkelsen1, 2, M. Andersen3, S. Heegaard1, 2. 1Ophthalmology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; 2Pathology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; 3Clinical Genetics, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

5585 — A0304 Clinical differentiation of non-Hodgkin orbital lymphoma and idiopathic orbital inflammation. Kamil G. Laban1, 2, R. van Aarle1, J. Kuiper1, 2, J. de Boer1, R. Kalmann1. 1Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands; 2Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

5586 — A0305 The pathological features of orbital lymphoma combined with orbital inflammation. Weimin He. Ophthalmology, West China Hospital, Chengdu, Sichuan, China

5587 — A0306 Ocular adnexal lymphoma in Denmark from 1980-2017 – a national study of 372 cases. Frederik Holm1, P. Ramussen1, L. H. Mikkelsen1, L. D. Sjö1, E. Ralfkiaer1, S. Heegaard1, 2. 1Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark; 2Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark

5588 — A0307 Toll-like receptors (TLRs) involvement in conjunctival marginal zone lymphomas. Sunny Shen1, 2, A. Chan2, 3. 1Oculoplastic, Singapore National Eye Centre, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore, Singapore; 3Singapore National Eye Centre, Singapore, Singapore

5589 — A0308 Clinical presentation and Treatment Outcomes of Primary Ocular Adnexal MALT Lymphoma in Thailand. Kasem Seresirikachorn1, S. Ausayakhun1, D. Wiwatwongwana1, L. Norasetthada2, S. Tangchittam3, V. Pruksakorn3, K. Wudhikorn4. 1Ophthalmology, Chiang Mai University, Bangkok, Thailand; 2Internal Medicine, Chiang Mai University, Chiang Mai, Thailand; 3Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; 4Internal Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand

5590 — A0309 Circumscribed Choroidal Hemangioma : Topographical Features. Arun D. Singh1, J. Krohn2, P. Rishi3. 1Ophthalmic Oncology, Cole Eye Institute, Solon, OH; 2Ophthalmology, Haukeland University Hospital, Bergen, Norway; 3Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India

5591 — A0310 Single photodynamic therapy session for exudative circumscribed choroidal hemangiomas. Clinical series of 33 patients. xavier proumen1, A. Guagnini2, P. Bartoszek1, A. Kozyreff2, P. De Potter1. 1Ocular Oncology Unit, Institut Roi Albert 2, CUSL, Brussels, Belgium; 2Retina Unit, Institut Roi Albert 2, CUSL, Brussels, Belgium

5592 — A0311 Long-term results of photodynamic therapy for circumscribed choroidal hemangioma. Yuko Hayashi, M. Kitahashi, T. Baba, T. Nizawa, M. Kubota, S. Yamamoto. Chiba University Graduate School of Medicine, Chiba, Japan

5593 — A0312 Plaque Radiotherapy as Treatment for Medulloepithelioma in 6 Cases at a Single Center. Su Mae Ang1, L. A. Dalvin1, 2, C. L. Shields1. 1Ocular Oncology, Wills Eye Hospital, Philadelphia, PA; 2Department of Ophthalmology, Mayo Clinic, Rochester, MN *CR

5594 — A0313 HPV16/18 and p16 gene expression in ocular surface squamous neoplasia: a retrospective cross-sectional analysis. Pavan Mann1, S. Diamond2, R. Masanganise3, L. Gwanzura4, Y. Liu5, R. T. Schooley5, J. H. Lin2, 56. 1School of Medicine, University of California San Diego, La Jolla, CA; 2Pathology, University of California San Diego, La Jolla, CA; 3Ophthalmology, Department of Surgery, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 4Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 5Medicine, University of California San Diego, La Jolla, CA; 6Ophthalmology, University of California San Diego, La Jolla, CA

5595 — A0314 Treatment with topical and subconjunctival interferon alfa 2b in ocular surface squamous neoplasia (OSSN). Nathalia Juliana Moreno1, E. Viteri1, V. Galvis2. 1Fundacion Oftalmologica de Santander, Bucaramanga, Colombia; 2Santander, Centro Oftalmologico Virgilio Galvis, Bucaramanga, Colombia

5596 — A0315 CD109: a novel marker for Ocular Surface Squamous Neoplasia differentiation. Prisca R. Bustamante, J. M. Lasiste, D. Miyamoto, S. Bergeron, C. Mastromonaco, L. Nuñez, M. N. Burnier. Pathology, MUHC McGill University, Montreal, Quebec, Canada

5597 — A0316 Correlation between High Resolution Optical Coherence Tomography features and Histological Diagnosis in Ocular Surface Squamous Neoplasia. Nallely Ramos Betancourt, J. Dávila Alquisiras, R. García-Vazquez, D. Yoshiro-Miyake. Cornea and Refractive Surgery, Asociación para Evitar la Ceguera en México, Mexico City, Mexico



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5605 — A0324 Adjuvant high-dose rate (HDR) brachytherapy for ocular tumours with orbital invasion. Monica M. Pagliara1, L. Tagliaferri2, A. Lanza1, L. Azario3, G. Savino1, R. Autorino2, a. scupola1, V. Valentini2, M. Blasi1. 1Ocular Oncology Unit, Department of Ophthalmology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy; 2Gemelli Advanced Radiation Therapy Center, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy; 3Physics Institute, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

5606 — A0325 The accuracy of orbital imaging in foretelling specific tumor diagnosis. Rita D. Page, T. Martz, O. Filutowski, Z. Karcioglu. Ophthalmology, University of Virginia, Charlottesville, VA

5607 — A0326 Prevalence of Ocular Findings in Patients with Central Nervous System Tumor in a Tertiary Hospital. Sabrina J. Cho, C. P. Gracitelli, D. A. Paulo, L. d. Noia. Ophthalmology and Visual Sciences, Federal University of Sao Paulo, Sao Paulo, SP, Brazil

5608 — A0327 Orbital varices. Rebecca M. Sieburth1, J. A. Matsumoto2, S. A. Newman1. 1Ophthalmology, University of Virginia, Charlottesville, VA; 2Radiology, University of Virginia, Charlottesville, VA

5609 — A0328 AZD4547 fibroblast growth factor receptor-1 inhibitor as a potential drug target for lacrimal gland adenoid cystic carcinoma. Ann Tran2, R. Doddapaneni1, W. Tao1, D. T. Tse2, 1, D. Pelaez1. 1Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Ophthalmology, Bascom Palmer Eye Institute - University of Miami, Miami, FL

5610 — A0329 Lacrimal Gland Adenoid Cystic Carcinoma in Chinese Patients: Local Recurrence, Metastasis, Mortality. JIE YANG. Ninth People’s Hospital of Shanghai, Shanghai, China

5611 — A0330 A xenograft model for lacrimal gland adenoid cystic carcinoma in mice. Jugchawin Kanokkantapong1, W. Tao1, C. Choi1, R. Doddapaneni1, D. T. Tse1, 2, D. Pelaez1, 2. 1Opthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Biomedical Engineering, University of Miami, Miami, FL


Thursday, May 03, 2018 8:15 AM-10:00 AMEye Movements/Strabismus/Amblyopia/Neuro-Ophthalmology

513 Thyroid and orbital diseases

Moderator: Howard S. Ying

5612 — A0331 99Tcm-Octreotide Scintigraphy and occult active Thyroid-Associated Ophthalmopathy in Pediatric Patients. Bin Sun, Z. Zhang. Shanxi Eye Hospital, Taiyuan, Shanxi, China

5613 — A0332 Measurement of Medial Wall Bowing and Clinical Associations in Thyroid Eye Disease. Christine L. Bokman, S. Ugradar, D. Rootman. Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA

5614 — A0333 New uses of short tau inversion recovery magnetic resonance imaging for the evaluation of Graves Ophthalmopathy activity. Tomas Ortiz Basso, R. L. Vigo, M. F. Shokida, J. M. Gonzalez Barlatay, c. pagano, G. Hernandez Gauna, E. J. Premoli. Ophthalmology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

5615 — A0334 Effect of systemic steroid and orbital radiotherapy on dry eye parameters in Thyroid Associated Orbitopathy (TAO). Nicole C. Tsim1, 2, J. Chin1, 2, R. Chan1, 2, C. Li1, 2, A. Law2, L. Y. Yeung2, K. Wong1, 2, A. Young1, 2, K. Chong1, 2. 1Department of Ophthalmology & Visual Science, Prince of Wales Hospital, Hong Kong, Hong Kong; 2Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong *CR

5616 — A0335&#tab; Long-term results of extraocular muscle surgery for thyroid ophthalmopathy. Akiko Kimura. Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan

5617 — A0336 Thyroid-associated orbitopathy in HIV patients. Eugenie W. Poh. Ophthalmology, Tan Tock Seng Hospital, Singapore, Singapore

5618 — A0337 The negative psychosocial impact of thyroid eye disease - comparing results from the CIRTED trial with strabismus and other facially disfiguring conditions. Shokufeh Tavassoli1, R. Rajendram2, V. Wilson3, P. White4, J. Uddin2, C. Dayan5, R. W. Lee1, S. Jackson4. 1Bristol Eye Hospital, Bristol, United Kingdom; 2Moorfields Eye Hospital, London, United Kingdom; 3University of Bristol, Bristol, United Kingdom; 4University of West of England, Bristol, United Kingdom; 5University of Cardiff, Cardiff, United Kingdom


5619 — A0338 How reliable are diagnostic ultrasounds of temporal arteries in comparison to temporal artery biopsies (TAB) in Giant Cell Arteritis? Anshu Sachdev1, M. George1, S. Dubey2, C. Tiivas3, P. Mehta1. 1Ophthalmology, University Hospital Coventry, Coventry, United Kingdom; 2Rheumatology, University Hospital Coventry, Coventry, United Kingdom; 3Medical Physics, University Hospital Coventry, Coventry, United Kingdom

5620 — A0339 Ultrasound Guided Intralesional Injection of Bleomycin for Orbital Lymphangioma- A prospective study. Bipasha Mukherjee1, S. G2. 1Orbit, oculoplasty, reconstructive & aesthetics, Medical Research Foundation, Chennai, India; 2Vitreoretina, Medical Research Foundation, Chennai, India

5621 — A0340 Hedgehog Pathway Inhibitors as Neoadjuvant Therapy for Orbital/Periorbital Basal Cell Carcinoma. Arthika Chandramohan1, A. Nair2, A. L. Chang1, A. Kossler1. 1Stanford University, Palo Alto, CA; 2New York University, New York, NY

5622 — A0341 Histological findings in the orbital biopsies of patients undergoing rituximab treatment – a case series. Matthew Starr, D. Salomao, J. Garrity. Mayo Clinic, Rochester, MN

5623 — A0342 Differences in surgical approach and tissue yield in adult orbital lesion biopsies. Alexander Knezevic, M. Mbagwu, H. Heymann, S. Eichinger, P. Thyparampil, P. Bryar. Northwestern University, Chicago, IL

5624 — A0343 Assessing the Accuracy of Intraoperative Frozen Sections for the Evaluation of Orbital Lesions. Michael Mbagwu, A. Knezevic, H. Heymann, S. Eichinger, P. Bryar. Department of Ophthalmology, Northwestern University, Chicago, IL

5625 — A0344 Peripheral rim enhancement: a radiographic clue for diagnosis of thrombosed orbital varices. Connor Nathe1, S. R. Grob1, 2, J. Tao1, 2, K. Feldman3. 1Department of Ophthalmology, University of California, Irvine School of Medicine, Irvine, CA; 2Gavin Herbert Eye Institute, University of California, Irvine, CA; 3Oculoplastic and Reconstructive Surgery, Kaiser Permanente South Bay Medical Center, Harbor City, CA

5626 — A0345 Clinical characteristics of retrobulbar hemorrhage following blow out fracture repair. Jaehwi Park1, H. Oh2, E. Cho1, W. Son1, S. Cha1, J. Son1. 1Ophthalmology dempartment, Yeungnam University Medical Center, Daegu, Korea (the Republic of); 2Bright eye clinic, Daegu, Korea (the Republic of)

5627 — A0346 The use of a thermo-responsive gel as a treatment material for enophthalmos. Katherine Duncan, M. A. Washington, M. V. Fedorchak, J. Y. Yu. University of Pittsburgh Medical Center, Baltimore, MD

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5644 — A0363 ATF3 inhibiting ASNS expression Contributes to Naphthalene Induced Cataract Development. Jing-Ying Xu2, 1, Y. YANG1, P. Shang1, C. Zhang2, q. Ou1, F. Gao1, H. Tian1, C. Jin1, L. Lu1, G. Xu1, 2. 1Lab of Visual Science, Tongji Univ School of Med, Shanghai, China; 2Department of Ophthalmology of Shanghai Tenth People’s Hospital, and Tongji Eye Institute, Tongji University, Shanghai, China

5645 — A0364 UV or H2O2 accelerated the opacification of LBs which could partially serve as age-related cataracts model. Lifang Zhang2, 1, Q. FU2, 1, Z. Qin2, 1, D. Lyu2, 1, K. Yao2, 1. 1Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang, China; 2Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

5646 — A0365 Using Grapes as a Magic Bullet to Fight Against Free Radicals in the Eye: Application for Cataract Prevention. Hongli Wu2, 1, X. Liu2, C. Xavier2, D. Wang2, P. Ananti2, Y. Liu1. 1North Texas Eye Research Institute, University of North Texas Health & Science Center, Fort Worth, TX; 2Pharmaceutical Sciences, UNT System College of Pharmacy, Fort Worth, TX

5647 — A0366 Differentiation and proliferation potential of lens epithelial cells ex vivo - possible cause for late intraocular lens dislocation. Jovana Bisevac1, 2, D. J. Szabo4, N. Anisimova3, R. Nagymihály1, A. Noer1, I. Sharafetdinov3, M. C. Moe1, 2, B. Malyugin3, G. Petrovski1, 2. 1Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; 2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 3S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation; 4Stem Cells and Eye Research Laboratory, Department of Ophthalmology, University of Szeged, Szeged, Hungary

5648 — A0367 Transparency Distribution of Cataractous Crystalline Lens from Analysis of Images Obtained by a Shack-Hartmann Wavefront Aberrometer. Toshifumi Mihashi1, Y. Hirohara2, S. Morishima2, H. Mori1, T. Hiraoka1, F. Okamoto1, T. Oshika1. 1Department of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Eye Care Technology Development Dept., Topcon Corp., Itabashi, Tokyo, Japan *CR, f

5649 — A0368 Quantifying crystalline lens opacities in Down syndrome with Anterior Segment OCT. Julie-Anne Little, P. S. Richardson, K. J. Saunders, A. S. Mahil. Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom

5650 — A0369 Hsa-let-7c-3p downregulates lens epithelial mesenchymal transition by inhibiting CDH11 in TGFβ induced anterior subcapsular cataract in retinitis pigmentosa. Min Hou2, F. Luo2, X. Bao2, M. Wu2, 1. 1Cataract, Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China; 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, Guang Dong, China

5628 — A0347 Ocular and Orbital Manifestations of PHACES Syndrome: A case series. Paul Huang1, 3, E. Sanders3, 1, A. Harrop1, 3, F. Kherani1, 2. 1University of Calgary, Calgary, Alberta, Canada; 2University of British Columbia, Vancouver, Alberta, Canada; 3Alberta Health Services, Calgary, Alberta, Canada

5629 — A0348 Risk Factors for Urgent Ophthalmologic Intervention in Orbital Fractures at a Level I Trauma Center. Georges Nassrallah, M. Ross, J. Deschenes. Ophthalmology, McGill University, Ottawa, Ontario, Canada

5630 — A0349 Deoxycholic Acid and the Marginal Mandibular Nerve: A Cadaver Study. Alex D. Blandford1, W. Ansari1, T. Plesec2, C. J. Hwang1, J. D. Perry1. 1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH; 2Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH

5631 — A0350 The role of the specialist in directing judicious imaging in children with periorbital cellulitis. Daniel Gealy, M. Migliori. Ophthalmology, Brown University, Providence, RI


Thursday, May 03, 2018 8:15 AM-10:00 AMLens

514 Cataractogenesis and PCO

Moderator: Linda Musil

5632 — A0351 CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study. Ruihua Jing, B. Ma, J. Liu, C. Pei. Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

5633 — A0352 SMAD7 mediated suppression of epithelial to mesenchymal transition markers in lens. Matthew L. Hupy1, M. G. Pedler1, B. Shieh1, D. Wang2, X. Wang2, J. Petrash1. 1Ophthalmology, University of Colorado School of Medicine, Aurora, CO; 2Pathology, University of Colorado School of Medicine, Aurora, CO *CR

5634 — A0353 AGEs promote TGFβ2-mediated EMT response through the non-canonical pathway. Ram H. Nagaraj, M. Nam. Ophthalmology, University of Colorado School of Medicine, Aurora, CO

5635 — A0354 Resveratrol inhibits cell growth, matrix contraction & EMT: a putative agent for PCO management. Andrew J. Smith, J. A. Eldred, M. Wormstone. School of Biological Sciences, University of East Anglia, Norwich, England, United Kingdom


5636 — A0355 Expression of proteoglycan decorin in opacified posterior capsule and its suppression by TGFβ in mouse lens epithelial cells. Shinsuke Shibata1, N. Shibata1, T. Shibata1, H. Ishida1, E. Kiyokawa2, H. Sasaki1, E. Kubo1. 1Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan; 2Department of Oncogenic Pathology, Kanazawa Medical University, Kahoku, Ishikawa, Japan

5637 — A0356 Regulation of TGF-β mediated epithelial-mesenchymal transition of lens epithelial cells by c-src kinase at high glucose concentration. Jian Zhou. Department of Ophthalmology, Xijing Hospital, Xi’an, Shaanxi, China

5638 — A0357 The Rho kinase signaling pathway can facilitate TGFβ-mediated matrix contraction and transdifferentiation of human lens epithelial cells to myofibroblasts. Michael Wormstone, A. J. Smith, J. A. Eldred. School of Biological Sciences, University of East Anglia, Norwich, England, United Kingdom *CR

5639 — A0358 Reactive oxidant species play a key role in sulforaphane induced MAPK signalling, autophagy and cell death in human lens epithelial cells. Ngoc Phuong Thao Huynh1, h. liu2, S. Ball1, A. J. Smith1, R. P. Bowater1, M. Wormstone1. 1School of Biological Sciences, University of East Anglia, Norwich, United Kingdom; 2Beijing Tongren Eye Center, Beijing, China

5640 — A0359 Aβ-potentiated and Aβ-independent age-related changes in the lens of Alzheimer’s Disease and wild-type mice. Juliet A. Moncaster1, M. Wojnarowicz2, O. Minaeva1, R. Zeng1, L. E. Goldstein1. 1Radiology, Boston University, Boston, MA; 2Pathology and Laboratory Medicine, Boston University, Boston, MA

5641 — A0360 Targeted depletion of Myo/Nog cells during cataract surgery significantly reduces posterior capsule opacification in the rabbit. Jacquelyn V. Gerhart1, L. Werner2, N. Mamalis2, C. Withers1, R. Getts3, M. George-Weinstein1. 1Research, Philadelphia College of Osteopathic Medicine, Philadelphia, PA; 2John Moran Eye Center, University of Utah, Salt Lake City, UT; 3Genisphere, Hatfield, PA *CR

5642 — A0361 Cytokine profile in aqueous humor of congenital cataract with posterior capsule defect. Yinying Zhao, p. chang, Z. Li, X. Ding, Y. Zhao. the eye hospital affiliated wenzhou medical university, Wenzhou, China f

5643 — A0362 Clinical and Morphological Features in a Family with Congenital Cataract and Macular Hypoplasia. Karsten Hufendiek1, D. Brockmann1, A. Ashurov1, O. Greb1, T. Neuhann2, H. Stoehr3, K. Hufendiek1, C. Framme1. 1University Eye Hospital, Hannover Medical School, Hannover, Germany; 2MGZ - Medizinisch-Genetisches Zentrum, Munich, Germany; 3Human Genetics, University of Regensburg, Regensburg, Germany


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5651 — A0370 ER Stress involves in lens capsular opacification through regulating EMT in lens epithelium. Jing Yang, S. Zhou, Y. Liu, M. Wang, Y. Liu. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, Guangzhou, China; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, Guangzhou, China

5652 — A0371 Ginkgolic Acid Inhibits Aberrant Sumoylation-Mediated Dysregulation of Prdx6 and Sp1 to Protect Lens Epithelial Cells against Oxidative Injury. Dhirendra P. Singh1, B. Chhunchha1, g. won1, E. Kubo2. 1Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE; 2Ophthalmology, Kanazawa Medical University, Kanazawa, Ishikawa, Japan

5653 — A0372 Comparison between injectable anesthetic agents on transient cataract induced by general anesthesia in rats. Atsuko Yamashita, O. Sakai, H. Tokushige. SENJU Pharmaceutical Co., Ltd, Kobe, Hyogo, Japan *CR


Thursday, May 03, 2018 8:15 AM-10:00 AMPhysiology/Pharmacology

515 Gene therapy, implants

Moderator: Kristyn Huffman

5654 — A0373 Vector shedding and immunology results from a gene therapy clinical trial for choroideremia. Alun R. Barnard1, 2, A. Rudenko2, 1, K. Xue1, 2, R. E. MacLaren1, 2. 1Nuffield Lab of Ophthalmology, University of Oxford, Oxford, England, United Kingdom; 2Oxford Eye Hospital, Oxford University Hospitals NHS Trust and NIHR Biomedical Research Centre, Oxford, United Kingdom*CR, f

5655 — A0374 A Non-Viral Gene Therapy Approach for Retinitis Pigmentosa. Karine Bigot1, P. Gondouin1, P. Montagne1, R. Benard1, E. Picard3, 2, Y. G. Courtois3, 2, R. Buggage1, T. Bordet1, F. F. Behar-Cohen3, 2. 1Eyevensys, Paris, France; 2Université Paris Descartes Sorbonne Paris Cité, Paris, France; 3Centre de Recherche des Cordeliers, INSERM UMRS1138, Paris, France *CR

5656 — A0375 Repeat Administration of AAV8 Vector in the Mouse Eye Results in Transgene Expression. Lisa L. Wei1, Y. Zeng2, S. Hiriyanna1, Z. Wu1, P. Sieving1, R. A. Bush2. 1National Eye Institute, Bethesda, MD; 2National Institute on Deafness and Communication Disorders, Bethesda, MD


5657 — A0376 Assessment of transduction efficiency and tropism of different adeno-associated virus (AAV) serotypes based on route of delivery in rats. Ian C. Han1, 2, C. Jiao1, 2, E. E. Kaalberg1, 2, S. Bhattarai1, 2, E. R. Burnight1, 2, B. A. Tucker1, 2, R. F. Mullins1, 2, E. M. Stone1, 2. 1Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA; 2Stephen A. Wynn Institute for Vision Research, Iowa City, IA

5658 — A0377 Ocular Safety of AAV2.7m8-ChrimsonR-tdTomato (GS030-DP) following intravitreous injection and exposure to 595 nm LED light in blind rd1 mice. Brian J. Christian1, S. D. Sorden1, M. Ward1, T. M. Nork2, P. E. Miller2, A. Douar3, N. Thomasson3, C. Bouquet3. 1Covance Laboratories, Inc, Madison, WI; 2Ocular Services On Demand, Madison, WI; 3GenSight Biologics, Paris, France *CR

5659 — A0378 Optimized Homology Directed Repair for Treatment of Inherited Retinal Diseases Using the CRISPR/Cas9 System. Brian P. Rossmiller, T. Iwata. Molecular and Cellular Biology, The National Hospital Organization, Tokyo, Japan

5660 — A0379 The effect of Surgical removal of the Internal Limiting Membrane on AAV vector delivery to the Retina in a Non-Human Primate model. Kelvin Teo1, 2, S. Lee3, I. Constable4. 1Medical Retina, Singapore National Eye Centre, Sydney, New South Wales, Australia; 2Medical Retina, Sydney Eye Hospital, Sydney, New South Wales, Australia; 3Retina, Singapore National Eye Centre, Singapore, Singapore; 4Lions Eye Institute, Perth, Western Australia, Australia

5661 — A0380 Modulation of gene transduction by rAAV2 in the rat retina after intravitreal injection. Mariana Santana Dias, V. Guedes de Araujo, R. Linden, H. Petrs Silva. IBCCF - UFRJ, Rio de Janeiro, RJ, Brazil

5662 — A0381 Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5. Ryan F. Boyd1, J. T. Bartoe1, T. S. Vihtelic1, S. L. Boye2, S. E. Boye2. 1Ophthalmology Services, MPI Research, Inc, Mattawan, MI; 2Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL

5663 — A0382 Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells. Victoria Splith, S. Boehm, J. Wagner, M. Biel, E. Becirovic, S. Michalakis. LMU Munich, Muenchen, Germany

5664 — A0383 Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa. Johanna Wagner1, C. Schön1, C. O’Riordan2, A. Scaria2, S. Cheng2, M. Biel1, S. Michalakis1. 1Ludwig-Maximilians Universität, Munich, Germany; 2Gene Therapy, Rare Diseases, Sanofi, Framingham, MA

5665 — A0384 Novel Approach to treat Wet Age-Related Macular Degeneration (wAMD) and other Retinal Vascular Diseases. Mark C. Butler1, 2, U. Chitgupi3, J. Myers1, 2, M. D. Anger1, 2, J. Lovell3, J. M. Sullivan1, 2. 1Research Service, VA Western NY Healthcare System, Buffalo, NY; 2Ophthalmology, (Ross Eye Institute), University at Buffalo-SUNY, Buffalo, NY; 3Biomedical Engineering, University at Buffalo-SUNY, Buffalo, NY

5666 — A0385 Complement Membrane Attack Complex activates the NLRP3 inflammasome in experimental autoimmune uveitis and inhibition by AAV mediated delivery of sCD59. Binit Kumar, S. Cashman, R. Kumar-Singh. Developmental Molecular & Chemical Biology, Tufts University School Of Medicine, Boston, MA

5667 — A0386 Optimization of Mitochondrial AAV-Mediated Gene Delivery for Outer Retina and Glia. Cecile Fortuny1, E. A. Zin1, J. Ngo1, C. Dunlap1, J. G. Flannery1, 2. 1Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA; 2HWNI, University of California, Berkeley, Berkeley, CA

5668 — A0387 CVCM: A polymeric delivery system for the ocular delivery of mRNA. Joanna Rejman, P. Baumhof. CureVac AG, Tubingen, Germany *CR

5669 — A0388 Wireless Oxygen Generator to Treat Retinal Ischemia. Juan Carlos Martinez1, 3, N. Scianmarello2, C. A. Cook2, K. Murali3, Q. Yang1, 3, A. H. Kashani1, 3, Y. Tai2, M. S. Humayun1, 3. 1Ophthalmology, USC Roski Eye Institute, Los Angeles, CA; 2MEMS Laboratory, California Institute of Technology, Pasadena, CA; 3 USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, CA

5670 — A0389 Safety and feasibility of new nanofiber subretinal delivery system with injector for RPE cell transplantation. Igor Kozak1, Z. Stranak2, S. Popelka3, T. Ardan4, D. Rais3, J. Cizkova4, S. Rohiwal4, J. Motlik4. 1Moorfields Eye Hospital Centre, Abu Dhabi, United Arab Emirates; 23rd Faculty of Medicine, Prague, Czechia; 3Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czechia; 4Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Prague, Czechia

5671 — A0390 Evaluation of Reproducibility and Uniformity of PRINT Implant Manufacturing. Melissa Sandahl1, D. Melton1, J. Tully1, M. Yang2, A. Garcia2, L. Trevino1, S. Williams1. 1Aerie Pharmaceuticals, Durham, NC; 2Envisia Therapeutics, Durham, NC *CR

5672 — A0391 Sustained Release, Biodegradable PEA Implants for Intravitreal Delivery of the ROCK/PKC Inhibitor AR-13503. Angela Glendenning, K. Crews, J. Sturdivant, M. A. deLong, C. Kopczynski, C. Lin. Aerie Pharmaceuticals, Durham, NC *CR

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5688 — A0407 Therapeutic potential and safety of sequential intravitreal dosing to the contralateral eye of novel AAV vectors in non-human primates. Annahita Keravala, A. Rosario, J. Nieves, C. Ceballos-Diaz, D. Cepeda, R. Zhang, A. Nguyen, M. Gasmi. Adverum Biotechnologies, Inc., Menlo Park, CA *CR

5689 — A0408 Degradation assessment of crosslinked CMHA-S polymer products for ophthalmic applications. Darren Stirland, C. Pompoco, B. Mann. EyeGate Pharmaceuticals, Salt Lake City, UT *CR

5690 — A0409 A Highly Bioavailable Nanocore (OcuSurf™) Brinzolamide Drug Product for Glaucoma Therapy, Compared to Azopt™. Koushik Barman, K. Ward, C. Li, S. P. Barman. Pharmaceutical Development, Integral BioSystems, Bedford, MA *CR

5691 — A0410 Corneal penetration of functionalized poly (N-isopropylacrylamide) (PNIPAM) polymers. Sudeep Kumar Gade1, R. Hoskins3, S. Rimmer3, P. Garg1, V. Venuganti2. 1Jhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India; 2Deapartment of Pharmacy, BITS Pilani Hyderabad Campus, Hyderabad, Telangana, India; 3School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom

5692 — A0411 Crosslinked Hyaluronic Acid (CMHA-S), Ocular Bandage Gel-based Delivery of Small Molecules. Hee-Kyoung Lee, S. Luo, B. Mann. EyeGate Pharma, Salt Lake City, UT *CR

5693 — A0412 Co-delivery of Dexamethasone-Melatonin-CoQ10 from a microparticulate drug delivery system. Potential usefulness in neuroprotective therapy. Alicia Arranz-Romera1, 2, E. Shamsher3, S. Esteban-Pérez1, 2, B. Davis3, D. Garcia-Herranz1, L. Guo3, I. Molina-Martínez1, 2, I. Bravo-Osuna1, 2, M. Cordeiro3, 4, R. Herrero-Vanrell1, 2. 1Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy(UCM920415), Complutense University of Madrid, Madrid, Spain; 2Red Temática de Investigación Cooperativa Sanitaria en Enfermedades Oculares Oftared e Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; 3Department of Visual Neuroscience, Glaucoma and Retinal Neurodegeneration Rearch,UCL Institute of Ophthalmology, London, United Kingdom; 4Western Eye Hospital, Imperial College London, London, United Kingdom

5694 — A0413 in vivo laser-mediated retinal ganglion cell optoporation using Kv1.1 conjugated gold nanoparticles. Ariel Wilson1, 3, J. Mazzaferri2, E. Bergeron3, S. Patskovsky3, S. Costantino2, M. Meunier3, M. Sapieha1. 1Biochemistry, Universite de Montreal, Montreal, Quebec, Canada; 2Ophthalmology, Universite de Montreal, Montreal, Quebec, Canada; 3Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada *CR


5673 — A0392 AR-1105 Dexamethasone Extended Release and Pharmacokinetics in the Non-Human Primate. Janet Tully1, S. Williams1, D. Melton1, R. Robeson2, M. Yang2, R. Verhoeven1. 1Aerie Pharmaceuticals, Durham, NC; 2Envisia Therapeutics, Durham, NC *CR

5674 — A0393 Development of Dissolution Assays for Ocular Implants. Jennifer Haley1, J. Tully1, M. Yang2, S. Williams1, J. Hansen1. 1Aerie Pharmaceuticals, Durham, NC; 2Envisia Therapeutics, Durham, NC *CR


Thursday, May 03, 2018 8:15 AM-10:00 AMPhysiology/Pharmacology

516 Drug and gene delivery systems

Moderators: Uday B. Kompella and Kristyn Huffman

5675 — A0394 Improving Retention Rates for Sustained Therapeutic Delivery Through Punctal Plugs. Deepank Utkhede, R. William. Mati Therapeutics Inc, Austin, TX *CR, f

5676 — A0395 Cornea-targeting peptide-functionalized nanomicelles with enhanced pharmaceutical efficacy on rabbit eye. Kaihui Nan. Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

5677 — A0396 Elastin-like polypeptide mediate subcutaneous delivery of Rapamycin in a murine model of Sjögren’s Syndrome. Changrim Lee1, H. Guo1, W. Klinngam1, S. R. Janga2, F. Yarber2, M. C. Edman2, S. Peddi1, S. F. Hamm-Alvarez2, 1, J. MacKay1, 2. 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA; 2Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA *CR

5678 — A0397 Non-Invasive Drug Delivery of Nanoparticles for the Treatment of Glaucoma Directly Targeting Schlemm’s Canal and Trabecular Meshwork. Molly M. Walsh1, j. west2. 1Ophthalmology, Duke University, Chapel Hill, NC; 2Biomedical Engineering, Duke University, Durham, NC *CR

5679 — A0398 Non-Clinical Safety of Ciliary Muscle Electrotransfection. Thierry Bordet1, K. Bigot1, R. Benard1, J. Laffitte1, E. Touchard1, R. Buggage1, F. F. Behar-Cohen1, 2. 1Eyevensys, Paris, France; 2Universite Paris Descartes, Paris, France *CR

5680 — A0399 Subtenon Transfusion Dexamethasone to treat Rabbit Experimental Autoimmune Uveitis. xuetao Huang, d. yiqin, M. Peng, K. Li, L. Zhao, C. Ye, D. Lin. Changsha aier hospital, Changsha, China

5681 — A0400 Novel Topical Formulation Reduces IOP for up to 34 Hours After a Single Dose. Monica M. Jablonski1, 3, D. N. Maria3, 2, M. M. Ibrahim1, 2. 1Hamilton Eye Institute, Univ Tennessee Health Sci Ctr, Memphis, TN; 2Pharmaceutics, Mansoura University, Mansoura, Egypt; 3Pharmaceutical Sciences, University of Tennessee Health Sci Ctr, Memphis, TN

5682 — A0401 Stereochemistry Enhances Potency and Duration of Effect of MALAT1 Antisense Oligonucleotides In Vivo in the Mouse. Michael Byrne, H. Yang, Y. Yin, A. Shah, L. Apponi, C. Shivalila, A. Durbin, N. Iwamoto, R. Looby, J. Kerner, K. Bowman, Z. Zhong, C. Vargeese. WAVE Life Sciences, Natick, MA *CR

5683 — A0402 DNA Nanoparticles for the Treatment of Retinal Diseases: in-vivo results. Sven Schnichels1, D. Simmang1, L. Strudel1, J. Hurst1, J. de Vries1, K. Bartz-Schmidt1, A. Herrmann3, M. S. Spitzer1, 2. 1University Eye Hosp Tübingen, Centre for Ophthalmology Tübingen, Tuebingen, Germany; 2University Eye Hospital, Hamburg, Germany; 3DWI - Leibniz-Institute for Interactive Materials, Aachen, Germany *CR

5684 — A0403 Lipid DNA Nanoparticles – a versatile vehicle for anterior segment drug delivery. Lisa Strudel1, J. Hurst1, J. de Vries1, A. Gruszka1, K. Bartz-Schmidt1, A. Herrmann2, M. S. Spitzer1, 3, S. Schnichels1. 1University Eye Hospital, Department of Ophthalmology, T?bingen, Germany; 2DWI-Leibniz-Institute for Interactive Materials, Aachen, Germany; 3University Eye Hospital Hamburg Eppendorf, Hamburg, Germany *CR

5685 — A0404 Lipidoid-siRNA formulations promote gene silencing in differentiated and non-dividing ARPE-19, primary porcine and human embryonic stem cell-derived retinal pigment epithelial cells. Astrid Subrizi1, C. Yang1, T. Ilmarinen2, H. Skottman2, A. Urtti3, 4, J. Kjems1, 5. 1iNANO, Aarhus University, Aarhus, Denmark; 2Faculty of Medicine and Life Sciences, BioMeditech Institute, University of Tampere, Tampere, Finland; 3Centre for Drug Research, University of Helsinki, Helsinki, Finland; 4School of Pharmacy, University of Eastern Finland, Kuopio, Finland; 5Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

5686 — A0405 Development of dual corticosteroid loaded functionalized liposomes for enhanced drug delivery to the retinal endothelium. Anthoula Arta, F. Melander, T. L. Andresen, A. Urquhart. Micro- and Nanotechnology, Technical University of Denmark, Kgs. Lyngby, Denmark

5687 — A0406 Episcleral sustained ocular delivery of bromfenac and brinzolamide. Jacklyn H. Salmon1, S. Abbaraju2, S. Hanna3, L. Hamm3, R. Amin2, D. Culp4, B. C. Gilger1. 1Clinical Sciences, North Carolina State University, Raleigh, NC; 2Symmetry Biosciences, Research Triangle Park, NC; 3Origin Bioanalytical Laboratory, Inc., Rancho Cordova, CA; 4Powered Research, LLC, Research Triangle Park, NC


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369


5695 — A0414 Biocompatibility of dexamethasone-eluting contact lens. Amy Ross1, L. Bengani1, H. Kobashi3, D. S. Kohane2, J. B. Ciolino1. 1Ophthalmology, Schepens Eye Research Institute, Boston, MA; 2Anesthesia, Boston Children’s Hospital, Boston, MA; 3Ophthalmology, Keio University School of Medicine, Tokyo, Japan *CR

5696 — A0415 Long-term functional delivery of the human L-opsin cDNA via intravitreal administration of an AAV vector in Mongolian gerbils.. Diana Cepeda1, J. Ver Hoeve2, 3, M. Ni1, A. Keravala1, A. Phillips1, M. Gasmi1. 1Adverum Biotechnologies, Menlo Park, CA; 2OSOD, Madison, WI; 3University Of Wisconsin–Madison, Madison, WI *CR

5697 — A0416 Endophthalmitis Rates of Ranibizumab in Pre-Filled Syringes Compared to Vials. Zujaja Tauqeer1, P. Storey2, J. D. Wolfe3, B. Todorich4, A. R. Shah5, T. Koto6, A. Abbey7, Y. Morizane8, K. Jeng-Miller1, E. Chen5, P. Williams7, F. Shiraga8, A. Hirakata6, S. Garg2, Y. Yonekawa1, 9. 1Massachusetts Eye and Ear Infirmary, Boston, MA; 2Mid-Atlantic Retina, Wills Eye Hospital, Philadelphia, PA; 3Associated Retinal Consultants, Royal Oak, MI; 4Pennsylvania Retina Specialists, Camp Hill, PA; 5Retina Consultants of Houston, Houston, TX; 6Kyorin Eye Center, Tokyo, Japan; 7Texas Retina Associates, Dallas, TX; 8Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, Japan; 9Boston Children’s Hospital, Boston, MA *CR

5698 — A0417 Assessment of intravitreal pharmacokinetics using an in vitro eye model. Sachin S. Thakur, I. D. Rupenthal. Ophthalmology, University of Auckland, Auckland, New Zealand

5699 — A0418 Comparative study on ocular pharmacokinetics of gatifloxacin between continuous lavage and hourly topical instillation in rabbits. Xin Zhao1, X. Shen1, X. Zhang1, S. Shen1, H. Lu1, M. Wang2. 1R&D, Shenyang Sinqi Pharmaceutical Co,LTD, Shenyang, China; 2University of Arizona College of Medicine, Tucson, AZ

5700 — A0419 The effects of amniotic membrane transplantation on moxifloxacin delivery into the cornea evaluated by in-vivo two-photon microscopy. jin longyu1, W. Park1, W. Jeong1, K. Kim2, U. Jegal2, J. Lee2. 1School of medicine, Dong-A University, Busan, Korea (the Republic of); 2Pohang Unuiversity of science and technology, Pohang, Korea (the Republic of)

5701 — A0420 Differences in ocular tissue metabolism of WP-1303 (H-1129, a novel antiglaucoma agent) by species. Ayako Suzuki, M. Kimura, M. Yoda, S. Muratani, R. Arakawa, A. Naito. wakamoto pharmaceutical co., LTD, Ashigarakami-gun, Kanagawa, Japan *CR

5702 — A0421 Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of ophthalmic diseases. Katja Wosikowski1, B. Korbmacher2, M. Krampert3, I. Roehl3, M. Janicot1. 1Preclinical Research and Development, Isarna Therapeutics, Munich, Germany; 2Covance Preclinical Services GmbH, Münster, Germany; 3LGC AxoLabs, Kulmbach, Germany *CR

5703 — A0422 Portable Imaging Device for Monitoring Patient Eye Drop. Ruixue Liu, A. Eaton, W. Nelson, H. Wafapoor. Research, Retina Health Center, Fort Myers, FL *CR

5704 — A0423 A Refillable Drug Delivery Device to the Retina. Nobuhiro Nagai1, S. Saijo1, Y. Song1, H. Kaji2, M. Nishizawa2, T. Abe1. 1Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; 2Graduate School of Engineering, Tohoku University, Sendai, Japan *CR

5705 — A0424 Accuracy and Precision of Intravitreal Injections of Anti-VEGF Agents in Real Life. Elad Moisseiev1, I. Loewenstein1, M. Goldstein1, J. Moisseiev2. 1Ophthalmology, Tel Aviv Medical Center, Ramat Hasharon, Israel; 2Ophthalmology, Sheba Medical Center, Ramat Gan, Israel

5706 — A0425 Sustained release protein formulation for intraocular use. Sahar Awwad1, 2, P. T. Khaw2, S. Brocchini1, 2. 1UCL School of Pharmacy, London, United Kingdom; 2National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom

5707 — A0426 Ocular Pharmacokinetics of WP-1303 (H-1129), a novel antiglaucoma agent, in rabbits. Moto Kimura, M. Yoda, A. Suzuki, S. Muratani, H. Miyai, R. Arakawa, A. Naito. wakamoto pharmaceutical co.,LTD, Ohi-machi, Kanagawa, Japan *CR

5708 — A0427 Study into the ability of viral and non-viral vectors to overcome vitreous and ILM in a vitreoretinal explant. Karen Peynshaert1, J. Devoldere1, A. Minnaert1, D. Dalkara2, H. Khabou2, S. De Smedt1, K. Remaut1. 1Ghent University, Ghent, Belgium; 2Insitut de la Vision, Paris, France

5709 — A0428 Ocular surface kinetics of fluorescein in human eyes: Effect of viscosity enhancing agents and drop size. Subashree Murugan1, P. Padmanabhan1, R. R. Sudhir1, A. Goyal1, D. Talele1, S. P. Srinivas2. 1Cornea and Refractive surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, India; 2School of Optometry, Indiana University, Bloomington, IN

Thursday – Posters –5695 – 5716

5710 — A0429 An Injectable Depot Formulation of an Outflow Prodrug for Sustained Reduction of Intraocular Pressure. Bryan Hoang1, C. Crean2, M. Yang1, A. Anonuevo1, W. Peterson1, J. Cleland1. 1Graybug Vision Inc, Baltimore, MD; 2Chatham Biopharma Consulting, Pittsboro, NC *CR

5711 — A0430 Dexamethasone-Eluting Contact Lenses Inhibit VEGF-Induced Retinal Vascular Leakage in a Rabbit Model. Lokendrakumar Bengani1, A. Ross1, H. Kobashi1, D. Maidana2, H. Zhai1, D. G. Vavvas2, D. S. Kohane3, J. B. Ciolino2. 1Harvard Ophthalmology, Schepens Eye Research Institute at Mass Eye & Ear, Boston, MA; 2Harvard Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA; 3Boston Children’s Hospital, Boston, MA *CR

5712 — A0431 Effects of enzymes on the fluid properties of vitreous. Aysan Rangchian1, A. A. Francone3, M. Farajzadeh3, K. Connelly2, J. Hubschman3, H. Kavehpour2, 1. 1Bioengineering, University of California, Los Angeles, Redondo Beach, CA; 2Mechanical Engineering, University of California, Los Angeles, Los Angeles, CA; 3Department of Ophthalmology - Retina Div, Jules Stein Eye Institute - UCLA, Los Angeles, CA

5713 — A0432 Sustained controllable sub-Tenon infusion for delivery of Dexamethasone to the experimental autoimmune uveitis. Libei Zhao1, 2, x. Huang1, 2, W. Lin1, 2, D. Lin1, 2. 1Aier School of Ophthalmology, Central South University, Changsha, China; 2Changsha Aier Hospital, Changsha, China

Exhibit Hall C0001-C0031

Thursday, May 03, 2018 8:15 AM-10:00 AMCornea

517 Corneal Imaging and Topography

Moderators: Patrice Tankam and Elena Koudouna

5714 — C0001 En-face spectral domain optical coherence tomography (SD-OCT) of the corneoscleral limbus. Ghouali Wajdene1, R. Tahiri Joutei Hassani1, H. Liang1, Z. Djerada2, M. El sanharawi1, A. Labbé1, C. Baudouin1. 1CHNO des Quinze-Vingts, Paris, France; 2Reims University Hospital, Reims, France*CR

5715 — C0002 Anatomic Feature of the Limbus Differs between Chinese and United States Populations. Qihua Le1, 2, D. Cordova1, J. Xu2, S. X. Deng1. 1Stein Eye Institute, UCLA, Los Angeles, CA; 2Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China *CR

5716 — C0003 Limbal and Conjunctival Epithelial Thickness in Ocular Graft-versus-Host Disease. Giulia Coco1, A. Kheirkhah1, V. Satitpitakul1, 2, R. Dana1. 1Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 2Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

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5730 — C0017 Application of high resolution anterior segment optical coherence tomography for non-invasive diagnosis and differentiation of benign lymphoid hyperplasia, conjunctival lymphoma and conjunctival amyloidosis. Nandini Venkateswaran, A. Tran, A. Galor, C. Karp. Ophthalmology, Bascom Palmer Eye Institute, Miami, FL

5731 — C0018 Postoperative detection of unusual pathology in Donor Corneal Tissue: A Case Series. Rasik B. Vajpayee1, 2, P. Finn3, 4, G. Pollock3, 4. 1Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia; 2Vision Eye Institute, Melbourne, Victoria, Australia; 3Lions Eye Donation Service, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; 4Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia

5732 — C0019 Automated classification of post orthokeratology corneal topography difference maps. Paul Gifford1, 3, C. Stancombe2, 3. 1Sch of Optometry & Vision Sci, University of New South Wales, Sydney, New South Wales, Australia; 23CS Software Pty Ltd, Brisbane, Queensland, Australia; 3Myopia Profile Pty Ltd, Brisbane, Queensland, Australia

5733 — C0020 Analysis of which device is reliable for measuring central corneal thickness in novice examiner. Yujeong Kim, J. Joung, S. Ryu, H. Lim. ophthalmology, Hanyang University Hospital, Seoul, Korea (the Republic of)

5734 — C0021 Comparison of corneal astigmatism with manifest refractive astigmatism in pseudophakic eyes. Omkar Thaware, M. Tang, D. Huang. Caesy Eye Institute, Oregon Health and Science University, Portland, OR *CR

5735 — C0022 Quantitative evaluation of corneal epithelial edema after cataract surgery using corneal densitometry. Sho Ishikawa, N. Kato. Saitama medical univercity, Moroyama, Japan

5736 — C0023 A Novel Low-Cost Photokeratoscope for Use with Smartphones. Alexander Bottini, E. Young, A. Qureshi, J. Young, E. Tsui. New York University School of Medi, New York, NY

5737 — C0024 Validation Study for Corneal Microlayer Tomography Automatic Segmentation Algorithm. Amr Elsawy4, I. O. Sayed-Ahmed1, d. wen1, V. Roongpoovapatr1, M. Ruggeri2, F. Manns2, 3, M. A. Mottaleb4, M. Abou Shousha1. 1Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL; 2Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 3Biomedical Engineering Department, University of Miami College of Engineering, Miami, FL; 4Electrical and Computer Engineering Department, University of Miami College of Engineering, Coral Gables, FL *CR

5717 — C0004 Novel method to detect corneal lymphatic vessels in vivo by intrastromal injection of fluorescein. Viet Nhat Hung Le. Ophthalmology, University of Cologne, Cologne, Germany

5718 — C0005 Differences in corneal nerves tortuosity indexes between healthy and diabetic subjects. Fabio Scarpa, A. Ruggeri. University of Padova, Padova, Italy

5719 — C0006 Building a validated in vivo confocal microscopy (IVCM) dataset for the study of corneal nerves. Davide Borroni1, 2, M. Beech1, B. Williams3, R. Liu4, Y. Zhao5, 3, B. Ma4, V. Romano1, U. Alam6, H. Qi4, S. B. Kaye1, 3, Y. Zheng3, 1. 1St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom; 2Department of Ophthalmology, Riga Stradins University, Riga, Latvia; 3Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; 4Department of Ophthalmology, Peking University Third Hospital, Beijing, China; 5Ningbo Institute of Industrial Technology, Cixi Institute of Biomedical Engineering, Ningbo, China; 6Clinical Sciences Centre, University Hospital Aintree, Institute of Ageing & Chronic Disease, Liverpool, United Kingdom

5720 — C0007 Evaluation of corneal nerve density with contact lens wear. Nicole M. Putnam1, S. Pilcher1, D. Bowin1, W. W. Harrison2, 1. 1Arizona College of Optometry, Midwestern University, Phoenix, AZ; 2College of Optometry, University of Houston, Houston, TX

5721 — C0008 Automated detection of corneal nerves using deep learning. Hong Qi1, 2, D. Borroni3, R. Liu1, 2, B. Williams4, M. Beech5, Y. Zhao7, 4, B. Ma1, 2, V. Romano5, U. Alam6, S. B. Kaye5, 4, Y. Zheng4, 5. 1Ophthalmology department, Peking University Third Hospital, Beijing, China; 2Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing, China; 3Department of Ophthalmology, Riga Stradins University, Riga, Latvia; 4Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; 5St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom; 6Institute of Ageing & Chronic Disease, Clinical Sciences Centre, University Hospital Aintree, Liverpool, United Kingdom; 7Cixi Institute of Biomedical Engineering, Ningbo Institute of Industrial Technology, Chinese Academy of Sciences, Ningbo, China

5722 — C0009 A Comparative Study of the Mouse and Human Corneal Elastic System. Eleanor M. Feneck2, P. N. Lewis2, J. Ralphs1, K. M. Meek2. 1School of Biosciences, Cardiff University, Cardiff, United Kingdom; 2School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom

5723 — C0010 Reliability and repeatability of in vivo corneal confocal imaging in young patients with type 1 diabetes mellitus. Noemi Toth1, E. Szalai1, E. Deak1, 2, A. Berta1, A. Biro3, T. Peto4, A. Csutak1. 1Department of Ophthalmology, University of Debrecen, Debrecen, Hungary; 2Biomarker Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; 33T Research Kft, Debrecen, Hungary; 4Centre for Public Health, Queen’s University Belfast, Belfast, United Kingdom

5724 — C0011 Comparison of metrics obtained with discriminant analysis and decision trees for the detection of subclinical keratoconus. Jens Buehren1, 2, S. Kleinhans2, E. Herrmann3, T. Kohnen2. 1Augenpraxisklinik Triangulum, Hanau, Germany; 2Dept. of Ophthalmology, Goethe University, Frankfurt am Main, Hesse, Germany; 3Dept. of Biostatistics and Mathematical Modelling, Goethe University, Frankfurt am Main, Hessen, Germany *CR

5725 — C0012 Agreement between keratometry measurements obtained with full gradient topography and Scheimpflug tomography systems in pre- and postoperative LASIK eyes. Janice Tarrant, S. Kasthurirangan. Abbott Medical Optics, Martinez, CA *CR

5726 — C0013 Corneal Ectasia Associated with Post-Operative Hypotony. Kai Kang, E. Tu, A. Aref, J. Wilensky, T. S. Vajaranant. Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL

5727 — C0014 Co-/Cross-polarized channel supported limbus to limbus corneal Epithelium (ET-) and Bowman’S Layer Thickness (BLT) Mapping in keratoconic eyes and healthy eyes using large Field of View (FoV-) Polarization-Sensitive (PS-) Optical Coherence Tomography (OCT). Niklas Pircher1, F. Beer2, S. Holzer1, J. Lammer1, M. Pircher2, C. K. Hitzenberger2, G. Schmidinger1. 1Ophthalmology, Medical University of Vienna, Vienna, Austria; 2Center for Med Pyhs & Biomed Eng, Medical University of Vienna, Vienna, Austria

5728 — C0015 Validation of Smartphone Specular Microscopy: A new tool for endothelial cell analysis in resource-limited settings. Michael J. Fliotsos1, 2, J. Jalali3, O. Dryjski1, A. O. Eghrari1. 1Wilmer Eye Institute, Baltimore, MD; 2Johns Hopkins University School of Medicine, Baltimore, MD; 3Case Western Reserve University, Cleveland, OH

5729 — C0016 Clinical features and confocal microscopic findings of contact lens-related noninfectious keratitis. Naoyuki Morishige, K. Shinkai, Y. Soejima, T. Matsui. Ohshima Eye Hospital, Fukuoka, Fukuoka, Japan f



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5738 — C0025 Corneal topography, thickness and Fourier analysis in Fuchs endothelial corneal dystrophy using 1310 nm swept source optical coherence tomography. Anna Nowinska, S. Teper, E. Wylegala. Chair and Department of Ophthalmology, Medical University of Silesia, Katowice, Slaskie, Poland

5739 — C0026 High Resolution Anterior Segment Optical Coherence Tomography of Microbial and Autoimmune Keratitis. Jeffrey Ma, R. Feder. Ophthalmology, Northwestern University, Chicago, IL

5740 — C0027 A New Method for Computation of Important Metrics for Corneal Disease Diagnosis. Farzana Nasrin, R. Iyer, S. Mathews. Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX

5741 — C0028 Dynamic Focusing Spiral Scan OCT for High Resolution, Wide Field, Corneal and Anterior Chamber Imaging. Yuxiao Wei2, R. P. McNabb1, O. Carrasco-Zevallos2, M. Jackson-Atogi1, J. A. Izatt2, 1, A. N. Kuo1, 2. 1Ophthalmology, Duke University, Durham, NC; 2Biomedical Engineering, Duke University, Durham, NC *CR

5742 — C0029 Three-Dimensional Bowmans Microlayer Optical Coherence Tomography for the Diagnosis of Subclinical Keratoconus. Vatookarn Roongpoovapatr1, A. Elsawy2, D. Wen1, J. Kanokkantapong1, I. O. Sayed-Ahmed1, Z. Syed1, M. A. Mottaleb2, S. H. Yoo1, M. Abou Shousha1. 1Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Electrical and computer engineering, University of Miami, Miami, FL *CR

5743 — C0030 Assessment of Keratoconus Prevalence in a Pediatric Population of Riyadh Saudi Arabia. Andre L. Piccinini, E. Torres, F. Hafezi, N. L. Hafezi, J. B. Randleman. Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, CA

5744 — C0031 Keratometry correlation and vector analysis of astigmatism using IOLMaster 500 and Pentacam HR – a pilot study in toric IOL candidates. Daniela L. Marques1, F. Langella1, H. Y. Kurimori1, R. Y. Hida1, i. C. Teixeira1, 2. 1Ophthalmology, Hospital Santa Casa de São Paulo, Sao Paulo, Brazil; 2Ophthalmology, Hospital de Olhos Paulista, Sao Paulo, Brazil


Thursday, May 03, 2018 8:15 AM-10:00 AMCornea

518 Cornea Surgery; Refractive

Moderators: Ryan Smith and Francisco C. Figueiredo

5745 — C0032 Secreted protein profiles of tear fluid following endothelial keratoplasty. Nobuyo Yawata2, 1, S. Awate2, Y. Liu1, 5, S. Yuan1, J. J. Siak1, 5, G. Daston3, J. S. Mehta1, 5, M. Yawata2, 4. 1Singapore Eye Research Institute, Singapore Eye Research Institute, Singapore, Singapore; 2Singapore Institute for Clinical Sciences, Singapore, Singapore; 3Procter and Gamble company, Cincinnati, OH; 4National University of Singapore, Singapore, Singapore; 5Singapore National Eye centre, Singapore, Singapore *CR

5746 — C0033 Develop a novel nomogram for manual astigmatic keratotomy to correct mild astigmatism during cataract surgery utilizing ORA and Verion. Ming Chen4, M. Reinsbach1, N. Wilbanks2, C. Chang3. 1Ophthalmology, Nassau university, New York, NY; 2Ophthalmology, University of Virginia, Charlottesville, VA; 3Taipei Nobel eye clinic, Taipei, Taiwan; 4Ophthalmology, University of Hawaii, Honolulu, HI

5747 — C0034 Visual and refractive outcomes of topography guided LASIK on virgin eyes. Sharif Hashmani, N. Hashmani. Ophthalmology, Hashmanis Hospital, Karachi, Sindh, Pakistan

5748 — C0035 Biases in patient-reported outcomes after laser vision correction. Neel D. Pasricha1, S. Hannan2, S. Schallhorn1, J. Schallhorn1. 1Ophthalmology, University of California, San Francisco, San Mateo, CA; 2Optical Express, Glasgow City, United Kingdom *CR

5749 — C0036 Central cornea regularization and collagen cross-linking in treatment of keratoconus. Francesco Cifariello, R. Dell’Omo, C. Costagliola. University of Molise, Campobasso, Molise, Italy

5750 — C0037 Outcomes in myopic LASIK and PRK. Kelly Krespan, J. M. Lustbader. Medstar Georgetown/Washington Hospital Center, Washington, District of Columbia

5751 — C0038 Reducing Spherical Aberration in LASIK Surgeries Using Periphery Modification Function. Guang-ming G. Dai, D. A. Chernyak, S. Kasthurirangan. R & D, Abbott Medical Optics, Milpitas, CA *CR


5752 — C0039 Three years follow-up of central flow toric implantable collamer lens implantation. Eduardo Martinez Sanchez, V. Oliva, A. Gomez Bastar, A. Lichtinger, A. Jimenez-Corona, E. O. Graue-Hernandez, A. J. Ramirez-Miranda, A. Navas. Instituto de Oftalmologia “Fundacion de Asistencia Privada Conde de Valenciana IAP”, Ciudad de Mexico, Mexico

5753 — C0040 Visual Quality and Contrast Sensitivity Function after Corneal Transplant. Jin Yuan1, J. Zhong1, Z. Lu2, F. Hou4, M. Dorr5, Z. Chen3, S. Deng3, J. Li3. 1Cornea, Zhongshan Ophthalmic Center, Guangzhou, China; 2Psychology Department, Ohio State University, Columbus, OH; 3Astigmatism, Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China; 4Wenzhou Medical University, Wenzhou, China; 5Technical University of Munich, Munich, Germany *CR, f

5754 — C0041 Hyperopia Lenticule Quality of Small Incision Lenticule Extraction in Rabbits Evaluated via Scanning Electron Microscopy. Yu Zhao, F. Zhao, T. Han, J. Zhao, X. Zhou. Fudan University, Shanghai, China

5755 — C0042 Corneal densitometry and polarization power 20 years after Excimer Laser Photorefractive Keratectomy. Feliciana Menna1, N. Rosa2, G. Cennamo3, D. Montorio1, F. Sinisi1, P. Donna1, P. Napolitano1, G. Cennamo1. 1Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry. University of Naples Federico II, Napoli, Italy, Napoli, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy, Napoli, Italy; 3Department of Public Health, University Federico II, Napoli, Italy, Napoli, Italy

5756 — C0043 Refractive Stability after LASIK-Xtra for Hyperopia and Astigmatism. Abraham Olvera-Barrios, K. Mohamed-Noriega, A. Garza-Briones, F. Morales-Wong, E. E. Cuervo-Lozano, G. Villarreal M?ndez, J. Mohamed-Hamsho. Universidad Autonoma de Nuevo Leon, Faculty of Medicine, University Hospital, Ophthalmology Department, Monterrey, Nuevo Leon, Mexico

5757 — C0044 Visual and Patient Reported Outcomes of Monovision LASIK versus Multifocal Intraocular Lens Implantation for the Treatment of Presbyopia. Craig Schallhorn1, J. Schallhorn2, S. Schallhorn3, 2, S. Hannan4. 1Flight Surgery, US Navy, San Diego, CA; 2Ophthalmology, University of California, San Francisco, San Francisco, CA; 3Zeiss, Dublin, CA; 4Optical Express, Glasgow, United Kingdom *CR

5758 — C0045&#tab; Six-Year Follow-up of SMILE (Small-Incision Lenticule Extraction) Procedure for the Correction of Astigmatism. Arturo J. Ramirez-Miranda, A. Navas, E. Gonzalez Mendoza, E. O. Graue-Hernandez. Cornea and Refractive Surgery, Inst of Ophthal “Conde de Valenciana”, Mexico City, DF, Mexico *CR

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5773 — C0060 Variation of potential pain biomarkers in saliva of patients after Advanced Surface Ablation (ASA) refractive technique. Eva Sobas Abad1, 2, A. Vazquez1, S. Videla3, R. Reinoso1, 4, I. Fernandez1, 4, M. J. Maldonado1, 5, J. Pastor1, 5. 1Ophthalmologhy, IOBA, Valladolid, Valladolid, Spain; 2Enfermería, Universidad de Valladolid, Valladolid, Valladolid, Spain; 3Ciencias Experimentales y de la Salud. Facultad de Ciencias de la Salud y de la Vida, Universidad Pompeu Fabra, Barcelona, Barcelona, Spain; 4Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Valladolid, Spain; 5Medicina, Universidad de Valladolid, Valladolid, Spain

5774 — C0061 Identifying Optimal Scheimpflug Parameters to Predict Ectasia Risk after LASIK. James B. Randleman1, E. Hwang1, J. M. Schallhorn2. 1Ophthalmology, USC Roski Eye Institute, Los Angeles, CA; 2Ophthalmology, UCSF, San Francisco, CA

5775 — C0062 Corneal Wound Healing and Inflammatory Responses following Femtosecond Laser LASIK and Small Incision Lenticule Extraction: Comparison of the Expression of Different Cytokines. Lingjia Liu1, W. Cheng3, G. Cheng4, K. Chiu5, Y. Wang2, 3. 1Medical College of Nankai University, Tianjin, China; 2Tianjin Eye Hospital & Eye Institute, Tianjin Key Lab of Ophalmology and Visual Science, NanKai University, Tianjin, China; 3Tianjin Medical University, Tianjin, China; 4 Hong Kong Laser Eye Center, Hong Kong SAR, China; 5Department of Ophthalmology, State Key Laboratory of Brain and Cognitive Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

5776 — C0063 Correlation between cyclorotation and clinical parameters after iris registration followed by wavefront-optimized femtosecond-assisted LASIK. Ricardo M. Nose, S. Basak, R. Pineda II. Refractive Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA

5777 — C0064 Safety and efficacy of accelerated corneal crosslinking with laser in situ keratomileusis (3 years). Jing Zhang, Y. Zhou. Beijing Tongren Hospital, Beijing, China

5778 — C0065 Astigmatic Outcomes for Arcuate Incisions in Femtosecond Laser Assisted Cataract Surgery. Giovanni Greaves1, B. Wong1, A. Malik1, S. Malik1, T. Hufnagel2, L. Rosen3, C. Shih1. 1Ophthalmology, Northwell Health, Hofstra School of Medicine, Baltimore, MD; 2Stahl Eye Care, Garden City, NY; 3Statistics, Northwell Heatlh, Feinstein Institute, Great Neck, NY

5779 — C0066 Changes in the Density of Choroicapillary and Choroidal Thickness in Myopic Patients with Femtosecond Laser in Situ Keratomileusis. Liang Hu, S. Gui, J. Huang, Z. Xu, F. Lu. School of Optometry & Ophthalmology,Wenzhou Medical University, Wenzhou, China

5759 — C0046 Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 Years with Progressing Keratoconus. Julia Polido1, M. Araújo1, E. Nakano1, T. Wakamatsu1, L. Mello2, T. Cabral1, 2, D. Freitas1. 1Ophthalmology, UNIFESP, Vitória, ES, Brazil; 2Ophthalmology, UFES, Vitória, ES, Brazil

5760 — C0047 A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan. Akira Kobayashi, T. Nishino, H. Yokogawa, N. Mori, T. Masaki, K. Sugiyama. Dept of Ophthalmology, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan

5761 — C0048 Biomechanical stability after Small Incision Lenticule Extraction (SMILE) using a 110 or 160μm cap thickness: An ex-vivo study on human donor corneas. Iben B. Damgaard, A. Ivarsen, J. Hjortdal. Department of Ophthalmlology, Aarhus University Hospital, Aarhus C, Denmark

5762 — C0049 Development of a Liquid Dissection Technique for Small-Incision Lenticule Extraction: Clinical Results and Ultra-Structural Evaluation. Shengbei Weng, Q. Liu. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China, Guangzhou, Guangdong, China

5763 — C0050 Corneal Higher-Order Aberrations of the Anterior, Posterior and Total Cornea After Pterygium Surgery. AYAKO TSUCHIYA1, T. Hayashi1, 2, T. Shimizu1, 2, N. Kato3. 1Ophthalmology, Yokohama Minami Kyosai Hospital, Yokohama, Kanagawa, Japan; 2Ophthalmology, Yokohama City University Hospital, Yokohama, Kanagawa, Japan; 3Ophthalmology, Saitama Medical University Hospital, Kawagoe, Saitama, Japan f

5764 — C0051 Reverse changes in corneal shape post FS-LASIK. Fangjun Bao1, S. Chen1, Y. Li1, Q. Wang1, A. Elsheikh2. 1The affiliated Eye Hospital, WenZhou Medical University, WenZhou City, China; 2University of Liverpool, Liverpool, United Kingdom

5765 — C0052 Clinical results of SMILE in treating high myopic errors exceeding 10 Diopters. Xiaonan Yang1, 2, Q. Liu1, 2. 1Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China; 2State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China

5766 — C0053 A Novel Femtosecond Laser Platform enabled by Hollow Core Photonics Crystal Fiber. Vladimir G. Lemberg, D. Wong, S. Rahaman, H. Fu. Advanced R&D, Johnson & Johnson Vision, Milpitas, CA *CR

5767 — C0054 Laser presbyopia surgery with point-symmetry corneal correction. Jose Alberto Rodriguez Agudo1, 2, J. Park2, 3, J. Park3, S. Lee4, A. Jahn5, K. Park3. 1Institute of Fluid Mechanics, University of Erlangen-Nuremberg, Busan, Korea (the Republic of); 2FAU Busan Campus, Institute of Fluid Mechanics, Busan, Korea (the Republic of); 3ShapeVision, Hwaseong, Korea (the Republic of); 4Lee Seong Su Eye Center, Jinju, Korea (the Republic of); 5Department of Bio-chemical Engineering, Dongseo University, Busan, Korea (the Republic of) *CR

5768 — C0055 Long Term Effects of using Intra-stromal Mitomycin-C with Small Aperture Corneal Inlay Implantation for Presbyopia Correction. Majid Moarefi, S. Bafna, W. Wiley. Cataract and Refractive Surgery, Cleveland Eye Clinic, Cleveland, OH *CR

5769 — C0056 Predicting Undercorrection of Myopia After Small Incision Lenticule Extraction using Corneal Topographic and Biomechanical Properties. Yan Wang1, 2, Y. Zhang2, W. Wu1, 2, J. Young3, K. Hatch4, U. V. Jurkunas4, R. Pineda II4, T. Elze5, M. Wang5. 1Tianjin Eye Hospital & Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, NanKai University, Tianjin, China; 2Tianjin Medical University, Tianjin, China; 3Department of Ophthalmology, NYU Langone Health, New York, NY; 4Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 5Schepens Eye Research Institute, Harvard Medical School, Boston, MA *CR

5770 — C0057 Excimer laser-assisted SMILE lenticule reshaping to induce topographical and refractive changes in porcine corneas. Andri K. Riau1, I. B. Damgaard2, Y. Liu1, M. Tey1, G. Yam1, J. S. Mehta3, 1. 1Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore; 2Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark; 3Singapore National Eye Centre, Singapore, Singapore *CR

5771 — C0058 Determinants of using adjuvant method modulated anxiety and pain in LASIK. Suvin Choi1, S. Park3, S. Chung2. 1Graduate School of Public Health & Institute of Health and Environment, Seoul National University, Seoul, Korea (the Republic of); 2Ophthalmology, Saevit Eye Hospital, Goyang, Korea (the Republic of); 3Department of Applied Statistics, Chung-Ang University, Seoul, Korea (the Republic of) f

5772 — C0059 Clinical outcomes after intracorneal ring segment implantation for keratoconus management in thin corneas. Zisis Gatzioufas1, 2, L. Eggenschwiler1, D. Goldblum1, I. Guber2, A. Khine2, S. Hamada2, D. Lake2, M. Elalfy2. 1Ophthalmology, University Hospital Basel, Basel, Switzerland; 2Corneo-Plastic Unit, Queen Victoria Hospital, East Grinstead, Sussex, United Kingdom



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5780 — C0067 Comparative Analysis of Dual Scheimpflug Metrics in Patients With Highly Asymmetric Keratoconus. Oren Golan1, E. Hwang2, M. Krauthammer1, J. B. Randleman3. 1Ophthalmology, Tel Aviv Soraski Medical Center, Valley Village, CA; 2University of South California, Los Angeles, CA; 3Ophthalmilogy, USC Roski Eye Institute, Los Angeles, CA

5781 — C0068 Effect of angle kappa on deviation of corneal vertex after small incision lenticule extraction (SMILE) for the correction of myopia. Wenbo Cheng, Y. Wang, J. Zhang, L. Zhang, T. CUI, W. Zhao. Tianjin eye hospital & eye institute, Tianjin key lab of ophthalmology and visual science,Tianjin medical university, Tianjin, China


Thursday, May 03, 2018 8:15 AM-10:00 AMEye Movements/Strabismus/Amblyopia/Neuro-Ophthalmology

519 Fixational Eye Movements and Nystagmus

Moderator: Vallabh Das

5782 — C0069 A novel reversible technique for treating congenital nystagmus. Lejin Wang, Z. Miao, L. Huang. Department of Ophthalmology, Eye diseases and optometry Institute, Peking University People’s Hospital, Beijing, China

5783 — C0070 Monocular nystagmus in chiasmal tumors. John P. Kelly1, 2, M. Estrada2, J. Wright3, J. O. Phillips1, 2, A. H. Weiss1, 2. 1Ophthalmology OA.5.342, Seattle Children’s Hospital, Seattle, WA; 2Ophthalmology, University of Washington, Seattle, WA; 3Radiology, Seattle Childrens Hospital, Seattle, WA

5784 — C0071 The contribution of common population variants to hypomorphic oculocutaneous albinism phenotypes: a novel tri-allelic TYR genotype. Chelsea S. Norman1, L. O’Gorman1, J. Gibson1, R. J. Pengelly1, D. Baralle1, J. Ratnayaka1, S. Ennis1, J. E. Self1, 2. 1The University of Southampton, Southampton, Hampshire, United Kingdom; 2Eye unit, University Hospital Southampton, Southampton, United Kingdom

5785 — C0072 A UKGTN approved next-generation sequencing clinical test for Albinism and/or Nystagmus. James E. Self1, L. Michaels1, T. Newall1, D. Hunt2, C. Norman1, S. Thomas3. 1CES, University of Southampton, Southampton, Hampshire, United Kingdom; 2Clinical Genetics, University Hospital Southampton, Southampton, Hampshire, United Kingdom; 3Lab, Wessex Regional Genetics Lab, Salisbury, Wiltshire, United Kingdom

5786 — C0073 Role of Frmd7 in synaptic connectivity in the retina. Ahmed Salman. University of Southampton, Southampton, United Kingdom

5787 — C0074 A putative causal variant in SLC38A8 segregating with foveal hypoplasia in an autosomal recessive family with primary exotropia. Zia Chaudhuri1, 2, J. John2, A. Mukhopadhyay2, S. Aneja3, B. Thelma2. 1Department of Ophthalmology, Lady Hardinge Medical College & PGIMER, Dr RML Hospital, New Delhi, India, New Delhi - 110001, Delhi, India; 2Department of Genetics, University of Delhi South Campus, New Delhi, India, New Delhi - 110021, Delhi, India; 3Department of Pediatrics, Lady Hardinge Medical College, University of Delhi, New Delhi, India, New Delhi - 110001, Delhi, India

5788 — C0075 Comparison of quantitative segmentation analysis and structural grading of foveal hypoplasia in infants for the prediction of future visual acuity: A longitudinal cohort study. Sohaib R. Rufai2, M. G. Thomas2, R. Purohit2, H. Lee1, F. A. Proudlock2, I. Gottlob2. 1Ophthalmology, University of Southampton, Southampton, Hampshire, United Kingdom; 2Ulverscroft Eye Unit, University of Leicester, Leicester, United Kingdom

5789 — C0076 Assessing visual acuity – test-retest repeatability and level of agreement between the electronic ETDRS chart (E-ETDRS), optokinetic nystagmus (OKN), and sweep VEP. Lily Yu-Li Chang1, 2, P. Guo2, B. Thompson3, M. Sangi4, J. Turuwhenua2, 1. 1Optometry & Vision Science, University of Auckland, Auckland, New Zealand; 2Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; 3Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada; 4Uniservices, University of Auckland, Objective Acuity Ltd, Auckland, New Zealand *CR

5790 — C0077 Age impairs OKN suppression during divided attention tasks. Larry A. Abel, R. Dyer. Optometry & Vision Sciences, University of Melbourne, Parkville, Victoria, Australia

5791 — C0078 Fixation stability with Bessel beams. Dipesh Bhattarai1, M. Suheimat1, A. J. Lambert2, D. A. Atchison1. 1School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia; 2School of Engineering and Information Technology, University of New South Wales, Canberra, Australian Capital Territory, Australia

5792 — C0079 How correlated are drifts in both eyes during fixational eye movements? Daria Ivanchenko1, Z. Hafed2, F. Schaeffel1. 1Section of Neurobiology of the Eye, Ophthalmic Research Institute, Tuebingen, Germany; 2Physiology of Active Vision, Werner Reichardt Centre for Integrative Neuroscience, Tuebingen, Germany

5793 — C0080 Similar multiplicative improvements in fixation stability in normal vision and amblyopia. Sevda Agaoglu1, A. M. Aizenman1, P. Verghese2, D. M. Levi1. 1School of Optometry, University of California, Berkeley, Berkeley, CA; 2The Smith-Kettlewell Eye Research Institute, San Francisco, CA

5794 — C0081 Longitudinal Results of the Relationship Between Saccadic and Fixation Movements to Birth Order. Christine L. Allison, D. G. Schlange. Binocular Vision/Pediatric Optometry, Illinois College of Optometry, Chicago, IL

5795 — C0082 Characteristics of Fixational Eye Movements During Prolonged Recording. Arun k. Krishnan1, 2, M. N. Agaoglu2, 3, S. T. Chung2, 3. 1Envision Research Institute, Wichita, KS; 2School of Optometry, University of California, Berkeley, CA; 3Vision Science Graduate Program, University of California, Berkeley, CA

5796 — C0083 Fixation instability during binocular viewing in strabismic and anisometropic children. Krista R. Kelly, C. Cheng-Patel, R. M. Jost, E. E. Birch. Pediatric Vision, Retina Foundation of the Southwest, Dallas, TX


Thursday, May 03, 2018 8:15 AM-10:00 AMVisual Psychophysics/Physiological Optics

520 Image Quality and Vision

Moderator: Nancy J. Coletta

5797 — C0084 Theoretical study of the effect of longitudinal vibrations on vision via the Visual Strehl ratio Optical Transfer Function metric. Andrei Martinez-Finkelshtein1, 2, A. Castaño-Fernández2, D. Iskander3. 1Mathematics, Baylor University, Waco, TX; 2Mathematics, University of Almeria, Almeria, Almeria, Spain; 3Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland

5798 — C0085 The impact of higher order wavefront aberrations dynamics on instantaneous retinal image quality. Maciej M. Bartuzel, D. Iskander. Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland

5799 — C0086 Correlation between Central and Peripheral Ocular Wavefront Aberrations in Young Adults. Jason Shen, F. Spors, D. Tsang. College of Optometry, Western Univ of Hlth Sciences, Pomona, CA

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5800 — C0087 The Influence of Pupil Size on Visual Image Quality and Optimal Refraction during Simulated Spectacle Wear in Keratoconus. Elizabeth Shumard1, G. D. Hastings1, J. J. Rozema2, R. A. Applegate1, J. D. Marsack1. 1College of Optometry, University of Houston, Houston, TX; 2Ophthalmology, University of Antwerp, Antwerp, Belgium

5801 — C0088 An attempt to determine normal range of corneal higher-order aberrations. Takahiro Hiraoka, G. Kiuchi, Y. Ueno, T. Oshika. Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan *CR

5802 — C0089 Relationships between corneal higher order aberrations, age, and refractive status. Gaku Kiuchi, T. Hiraoka, Y. Ueno, T. Oshika. University of Tsukuba, Tsukuba, Japan

5803 — C0090 Extending depth of focus of ophthalmic elements with trefoil aberration. Eva Acosta2, J. A. Arines2, M. Olvera-Ángeles1, A. Padilla-Vivanco1, J. Sasian3, J. Schwiegerling3. 1University of Tulancingo, Tulancingo, Hidalgo, Mexico; 2University of Santiago de Compostela, Santiago de Compostela, La Coruna, Spain; 3University of Arizona, Tucson, AZ

5804 — C0091 The impact of misalignment on the optical and visual image quality of template-based corrections in keratoconus. David Rio1, 2, J. J. Rozema3, 4, G. D. Hastings2, J. D. Marsack2. 1New England College of Optometry, Boston, MA; 2College of Optometry, University of Houston, Houston, TX; 3Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; 4Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

5805 — C0092 Central, Paracentral and Near-Peripheral Retinal Response to Chromatic Blur. Muteb Alanazi1, 2, J. Kim1. 1College of Optometry, Pacific University, Forest Grove, OR; 2College of Applied Medical Sciences, Optometry Department, King Saud University, Riyadh, Riyadh, Saudi Arabia

5806 — C0093 Method for assessing the impact of residual roughness after corneal ablation in polychromatic vision. Shwetabh Verma1, 2, J. Hesser2, S. Arba Mosquera1. 1Research and Development, Schwind eye-tech-solutions, Kleinostheim, Germany, Kleinostheim, Bayern, Germany; 2Experimental Radiation Oncology, Interdisciplinary Center for Scientific Computing, Central Institute for Computer Engineering, Heidelberg University, Heidelberg, Baden Württemberg, Germany *CR

5807 — C0094 In-Vivo Evaluation of Peripheral Refraction Changes with Single Vision and Multifocal Soft Contact Lenses. Frank Spors1, J. Shen1, D. Tsang1, L. McNaughton1, D. Egan2. 1Western University of Health Sciences, Pomona, CA; 2University of Pikeville, Pikeville, KY *CR

5808 — C0095 Influence of optical defocus on peripheral vision with and without aberrations. Petros Papadogiannis, D. Romashchenko, P. Unsbo, L. Lundström. KTH Royal Institute of Technology, Stockholm, Sweden

5809 — C0096 Study of the optical properties of two brands of commercial multifocal contact lenses (steep vs smooth addition increase) in combination with the higher order aberrations of 65 eyes. Pablo De Gracia, N. Purrier, C. Des Rosiers, A. Marcell, G. Pashak. Chicago College of Optometry, Midwestern University, Downers Grove, IL *CR

5810 — C0097 Elevation-based detection of keratoconus. Ikram Issarti1, 3, A. Consejo1, 2, J. J. Rozema1, 3. 1Department of Ophthalmology, Antwerp University Hospital, Antwerp, Belgium; 2Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland; 3Faculty of Medicine and Health Sciences, Antwerp University, Antwerp, Belgium

5811 — C0098 Assessment of corneal scattering using Purkinje images. Pau Santos1, J. Martínez-Roda1, J. Ondategui1, J. Cazal2, M. Ballesta1, F. Díaz-Doutón1, J. Pujol1, M. Vilaseca1. 1Centre for Sensors, Instruments and Sensors Development (CD6), Universitat Politècnica de Catalunya (UPC), Barcelona, Spain; 2Hospital CIMA Barcelona, Barcelona, Spain *CR

5812 — C0099 Stromal scattering mean-free path, as a quantitative measure of corneal transparency, derived from objective analysis of depth-resolved corneal images. Romain Bocheux1, 2, V. M. Borderie2, L. Laroche2, K. Plamann1, K. Irsch2, 3. 1Loa, Ensta ParisTech, École polytechnique, CNRS, Université Paris-Saclay, 828 bd des Maréchaux, 91762 Palaiseau, France; 2Institut de la Vision / Quinze-Vingts National Eye Hospital, UPMC-Sorbonne Universities, Paris, France; 3The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD

5813 — C0100 Scattering extinction of human eye lenses and straylight. Thomas J. Van Den Berg. Ophthalmic Research, Netherlands Inst for Neurosci, Royal Acad, Amsterdam, Netherlands*CR

5814 — C0101 Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy. Qianhui Yang1, 2, J. Martinez-Camarillo1, 2, C. A. Cook3, N. Scianmarello3, Y. Tai3, A. H. Kashani1, 2, M. S. Humayun1, 2. 1Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, CA; 2USC Institute of Biomedical Therapeutics, University of Southern California, Los Angeles, CA; 3Micro-ElectroMechanical Systems Lab, California Institute of Technology, Pasadena, CA

5815 — C0102 Case Series of Pediatric Sutured Scleral Lens Fixation in Guatemala City. Sofia Bravo-Beltranena1, M. Zimmermann-Paiz1, E. Hernandez Bogantes2. 1Comité Pro-Ciegos y Sordos de Guatemala, Guatemala, Guatemala; 2Centro Ocular, Heredia, Costa Rica


Thursday, May 03, 2018 8:15 AM-10:00 AMMultidisciplinary Ophthalmic Imaging Group / Biochemistry/Molecular Biology

521 Animal Imaging

Moderators: Ian A. Sigal and Joseph Carroll

5816 — C0103 Comparison of optical coherence tomography angiography with immunolabeling experiment in laser-induced choroidal neovascularization. Kazuki Nakagawa, H. Yamada, k. takahashi. Kansai Medical University Hospital, Osaka, Osaka, Japan

5817 — C0104 Detection of early microvascular retinal changes in type I diabetic mice with OCT-Angiography. Hironori Uehara, T. Lesuna, B. K. Ambati. University of Utah, Salt Lake City, UT

5818 — C0105 In vivo imaging of therapeutic response in the rat retina by anti-vascular growth factor inhibitors using optical coherence tomography angiography (OCT-A). Johanna Meyer, J. Groß, F. G. Holz, S. Schmitz-Valckenberg. Ophthalmology, University of Bonn, Bonn, Germany *CR

5819 — C0106 Retinal and choroidal blood perfusion in response to elevated intraocular pressure in male and female rats assessed by swept source OCTA. Yuandong Li1, J. Xu1, W. Cepurna2, E. C. Johnson2, D. C. Lozano2, J. C. Morrison2, R. K. Wang1, 3. 1Bioengineering, University of Washington, Seattle, WA; 2Casey Eye Institute, Oregon Health & Science University, Portland, OR; 3Ophthalmology, University of Washington, Seattle, WA *CR

5820 — C0107 Longitudinal characterization of branched retinal vein occlusions created by imaging-guided photocoagulation. Brian Soetikno, L. Beckmann, X. Zhang, H. Ryu, A. Fawzi, H. F. Zhang. Northwestern University, Chicago, IL

5821 — C0108 Retinal Characterization of SOD1-/- Mice by Multi-Functional OCT. Marco Augustin, D. J. Harper, S. Fialová, C. K. Hitzenberger, B. Baumann. Medical University of Vienna, Vienna, Austria



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5822 — C0109 Longitudinal monitoring of Photoreceptor-RPE-Choroid Neurovascular Unit (PRC-NVU) morphology and function in the mouse model of Doyne Honeycomb Retinal Dystrophy. Robert J. Zawadzki1, 2, R. Meleppat2, S. MANNA2, G. Peinado2, S. J. Karlen2, M. Heisler3, P. Zhang2, M. Sarunic3, E. A. Pierce4, E. N. Pugh2. 1Ophthalmology & Vision Science, University of California Davis, Sacramento, CA; 2Cell Biology and Human Anatomy, UC Davis, Davis, CA; 3Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada; 4Dept. of Ophthalmology, Harvard University, Boston, MA

5823 — C0110 Precise retinotopic mapping of rat visual cortex using high-speed and wide-field OCT angiography and fundus camera stimulator. Paul Shin, J. Joo, W. Oh. Korea Advanced Institute of Science and Technology, Daejeon, Korea (the Republic of)

5824 — C0111 Dependence of Optical Coherence Tomography Angiography on Microvessel Orientation Angle. Vivek J. Srinivasan1, 2, M. Bernucci1, C. M. Merkle1, J. Zhu1. 1Biomedical Engineering, University of California, Davis, Davis, CA; 2Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA *CR

5825 — C0112 Novel features of optophysiological signals from mouse rod outer segment tips observed by optical coherence tomography. Pengfei Zhang1, M. Goswami1, S. Manna1, R. Meleppata1, R. J. Zawadzki1, 2, E. N. Pugh1. 1Cell Biology, UC Davis, Davis, CA; 2UC Davis, Ophthalmology & Vision Science, Davis, CA

5826 — C0113 White Light Optical Coherence Tomography for Sub-Micron Resolution and Spectroscopic Imaging in the Mouse Retina. Danielle J. Harper1, M. Augustin1, A. Lichtenegger1, P. Eugui1, M. Glösmann2, C. K. Hitzenberger1, B. Baumann1. 1Medical University of Vienna, Vienna, Austria; 2University of Veterinary Medicine Vienna, Vienna, Austria

5827 — C0114 Subretinal Aβ injections induce a localised, early CNV phenotype in C57BL/6 mice. Savannah Lynn, J. Scott, H. h. Lee, R. Desai, T. Newman, A. Cree, A. Lotery, J. Ratnayaka. Clinical & Experimental Sciences, The University of Southampton, Southampton, United Kingdom

5828 — C0115 The Presence of Protein in Formulation Ameliorates Retinal Changes Observed on OCT Following Intravitreal Administration of Hyperosmotic Solution in Cynomolgus Monkeys. Nardos Tassew1, V. Bantseev1, A. McKenzie1, R. Andaya1, D. O’Connor1, D. Sheinson1, C. A. Rasmussen2, T. Nork2, T. Streit3, H. S. Booler1, F. Lorget1. 1Genentech, South San Francisco, CA; 2OSOD, Madison, WI; 3Covance Laboratories, Madison, WI *CR

5829 — C0116 Detection of melanin in the zebrafish retina using photothermal optical coherence tomography. Maryse Lapierre-Landry1, 2, A. L. Huckenpahler3, B. A. Link3, R. F. Collery4, J. Carroll4, M. Skala2, 5. 1Biomedical Engineering, Vanderbilt University, Nashville, TN; 2Medical Engineering, Morgridge Institute for Research, Madison, WI; 3Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI; 4Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI; 5Biomedical Engineering, University of Wisconsin Madison, Madison, WI

5830 — C0117 Noninvasive retinal imaging of small to large animals using ultrahigh-resolution optical coherence tomography without a contact lens. Sang-Won Lee1, 2, H. Kang1, T. Lee1, 2. 1Center for Nano-Bio Measurement, Korea Research Institute of Standards and Science, Daejeon, Korea (the Republic of); 2Department of Nano Science, University of Science and Technology, Daejeon, Korea (the Republic of)

5831 — C0118 A new look on Alzheimer’s and Parkinson’s disease: in vivo imaging of neurodegenerative disease processes in the retina. Lies De Groef1, L. Veys1, M. Vandenabeele1, L. Andries1, E. Lefevere1, L. Bousset2, C. Van den Haute3, I. Stalmans3, 4, R. Melki2, V. Baekelandt3, L. K. Moons1. 1Department of Biology, KU Leuven, Leuven, Belgium; 2Paris-Saclay Institute of Neuroscience, Centre National de la Recherche Scientifique, Paris, France; 3Department of Neurosciences, KU Leuven, Leuven, Belgium; 4University Hospitals Leuven, Leuven, Belgium

5832 — C0119 Wavelength-dependent OCT of the mouse retina in four spectral bands from visible to infrared. Aaron M. Kho1, C. M. Merkle1, R. Meleppata2, M. Bernucci1, T. Zhang1, P. Zhang2, S. Manna2, R. J. Zawadzki2, 3, V. J. Srinivasan1, 3. 1Biomedical Engineering, University of California, Davis, Davis, CA; 2Cell Biology and Human Anatomy, University of California, Davis, Davis, CA; 3Ophthalmology and Vision Science, University of California, Davis, Sacramento, CA *CR

5833 — C0120 Multimodal photoacoustic microscopy, OCT, and fluorescence imaging system to detect retinal neovascularization in rabbit eyes. Yanxiu Li1, 2, W. Zhang3, V. Nguyen3, X. Xia2, X. Wang3, Y. M. Paulus1, 3. 1Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, MI; 2Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China; 3Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI

5834 — C0121 Investigation of angular reflectivity of mouse retina layers using directional optical coherence tomography system. Ratheesh Kumar Meleppat1, P. Zhang1, E. N. Pugh1, R. J. Zawadzki1, 2. 1UC Davis Eye-Pod Imaging Laboratory, Dept. of Cell Biology and Human Anatomy, University of California Davis, Davis, CA; 2VSRI, Dept. of Ophthalmology & Vision Science, University of California Davis, Sacramento, CA

5835 — C0122 High Resolution Optical Coherence Elastography of Retina under Prosthetic Electrode. TAI-CHI LIN1, Y. Qu2, Y. He2, X. Qian3, Z. Chen2, Q. Zhou3, M. S. Humayun1. 1Department of Ophthalmology, USC Roski Eye Institute, Los Angeles, CA; 2Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, Irvine, CA; 3Department of Biomedical Engineering and Ophthalmology, University of Southern California, Los Angeles, CA *CR

5836 — C0123 Optical Observation of Retinal Ganglion Cells and their Apoptosis in Optic Nerve Degeneration. SeokHwan Kim1, J. Oh2, Y. kim3, J. Kim2, D. kim4, K. Park3, S. Park2. 1Ophthalmology, Seoul National University, Boramae Medical Center, Seoul, Korea (the Republic of); 2Sensor System Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea (the Republic of); 3Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of); 4Electrical Engineering, Inha University, Seoul, Korea (the Republic of)

5837 — C0124 Intravital imaging of corneolimbal cell dynamics by two-photon microscope. Yueh-Feng Wu1, H. Tan2, 3, S. Lin1, 4. 1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; 3College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan

5838 — C0125 Imaging Endoglin mRNA in Mouse OIR with Anti-Sense Hairpin-DNA Gold-Nanoparticle Conjugates. Md Imam Uddin, T. C. Kilburn, J. S. Penn. Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN

5839 — C0126 Development of imaging biomarkers of photoreceptor transplantation outcomes in mice based on confocal scanning laser ophthalmoscopy. Ying Liu, S. Sodhi, K. Hudspith, D. Johnson, M. S. Singh. Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD

5840 — C0127 Imaging Lutein and Zeaxanthin in the Primate Macula by Confocal Resonance Raman Microscopy. Binxing Li1, E. George1, G. T. Rognon1, F. Chang1, J. M. Frederick1, J. Stoddard2, T. J. McGill2, M. Neuringer2, P. S. Bernstein1. 1Ophthalmology and Visual Sciences, Univ of UT Sch Med/Moran Eye Ctr, Salt Lake City, UT; 2Ophthalmology, Oregon Health & Science University, Portland, OR


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5841 — C0128 Superresolution Ultrasound Imaging of the Rat Eye Vasculature. Harriet O. Lloyd1, A. Yu2, R. Urs1, B. Yiu2, J. Ketterling3, R. H. Silverman1. 1Ophthalmology, Columbia University Medical Center, New York, NY; 2Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada; 3F.L. Lizzi Center for Biomeidcal Imaging, Riverside Research, New York, NY

5842 — C0129 Microfluidic platform to study pressure-induced changes in neurons. Julie Cho1, P. Sternberg4, D. Colon-Ramos3, 2, C. Teng1. 1Ophthalmology, Yale University, New haven, CT; 2Developmental Cell Biology and Genetics, Yale University, New Haven, CT; 3Cellular Neuroscience, Neurodegeneration and Repair, Yale University, New Haven, CT; 4Biology, California Institute of Technology, Pasadena, CA

5843 — C0130 Intra and Inter-Observer Variability of Laser Speckle Flowgraphy for Retinal Blood Flow Measurements in Wild Type C57BL/6J Mouse Model. Veluchamy A. Barathi1, 2, R. Agrawal3, 1, P. K. Balne1, N. Khandelwal3, S. Tun1, L. Schmetterer4. 1Translational Pre-Clinical Model Platfor, Singapore Eye Research Institute, Singapore, Singapore; 2ophthalmology, The Ophthalmology & Visual Sciences ACP (EYE-ACP), SingHealth and Duke-NUS, Singapore, Singapore; 3ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore; 4Imaging group, Singapore Eye Research Institute, Singapore, Singapore

5844 — C0131 Simultaneous second harmonic generation and Mueller Matrix polarimetry imaging of the rat cornea. Ilyas Saytashev1, N. Lopez1, J. Chue-Sang2, J. Ramella-Roman1, 2. 1Opthalmology, HWCOM, Florida International University, Miami, FL; 2Biomedical Engineering, Florida International University, Miami, FL

5845 — C0132 A3ID - Automated Avascular Area Identification in a rat oxygen-induced retinopathy model. Michael Simmons1, 2, A. Cheng1, S. Becker1, R. Gerkin2, M. Hartnett1. 1Ophthalmology and Visual Sciences, Moran Eye Center, Salt Lake City, UT; 2Internal Medicine, Banner University Medical Center - Phoenix, Phoenix, AZ

5846 — C0133 Ultrahigh-field diffusion weighted MR imaging of the chicken eye in vivo throughout the in ovo period. Tobias Lindner1, F. Streckenbach3, R. Klose3, S. Hadlich4, T. Stahnke3, R. F. Guthoff3, S. Langner2, O. Stachs3. 1Core Facility Multimodal Small Animal Imaging, Rostock University Medical Center, Rostock, Germany; 2Institut für Diagnostische und Interventionelle Radiologie, Rostock University Medical Center, Rostock, Germany; 3Ophthalmology, Rostock University Medical Center, Rostock, Germany; 4Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany

5847 — C0134 Characterization of ocular anatomical and electrophysiological differences between young and geriatric African green monkeys. Shervin Liddie, C. Patel, V. Woodley, J. Attwood, A. Browne, M. S. Lawrence. Research, RxGen Inc., New Haven, CT

5848 — C0135 Alterations in inner retinal oxygen delivery and metabolism during bilateral common carotid artery occlusion in rats. Preny Karamian1, J. Burford1, S. Farzad1, N. P. Blair2, M. Shahidi1. 1Ophthalmology, University of Southern California, Los Angeles, CA; 2Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL *CR

5849 — C0136 Assessing seasonal changes of cone photoreceptor structure in the 13-lined ground squirrel. Benjamin S. Sajdak1, A. E. Salmon1, A. C. Williams2, D. K. Merriman3, J. Carroll1, 4. 1Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, WI; 2Clinical & Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI; 3Biology, University of Wisconsin Oshkosh, Oshkosh, WI; 4Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI

5850 — C0137 Complex organization of V1 projections to extrastriate cortex in tree shrew. Kuo-Sheng Lee1, 2, D. Fitzpatrick1. 1Max Planck Florida Institute, Jupiter, FL; 2Florida Atlantic University, Boca Raton, FL

5851 — C0138 Using ImageJ to quantify microbial keratitis related corneal opacification in a mouse model. Gibran Butt1, K. Brock1, A. Ng1, c. vareechon2, E. Pearlman2, L. J. Hill1, G. R. Wallace1, S. Rauz1. 1Institute of Inflammation and Ageing, University of Birmingham, Leeds, United Kingdom; 2Case Western Reserve University, Irvine, CA

5852 — C0139 Image-guided photo-mediated ultrasound therapy as a novel method to selectively treat eye vasculature. xinyi xie1, 3, W. Zhang1, 2, Y. Qin2, X. Yang4, X. Wang2, S. Yuan3, Y. M. Paulus1, 2, Q. Liu3. 1Ophthalmology, University of Michigan, Kellogg Eye center, Ann Arbor, MI; 2Biomedical Engineering, University of Michigan, Ann Arbor, MI; 3Ophthalmology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 4Mechanical Engineering, University of Kansas, Lawrence, KS

5853 — C0140 Characterization of Deeply Embedded Corneal Foreign Bodies with Anterior Segment Optical Coherence Tomography. Sharon Armarnik1, 2, M. Mimouni4, D. Goldenberg3, n. geffen5. 1Ophthalmology, BC Children Hospital, Vancouver, Prince Edward Island, Canada; 2Ophthalmology, Meir Medical Center, Kfar Saba, Israel; 3Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel; 4Ophthalmology, Rambam Health Care Campus, Haifa, Israel; 5Ophthalmology, Beilinson medical center, Petach Tikva, Israel

5854 — C0141 Mutations in the microphthalmia transcription factor (Mitf) gene affect retinal vessel diameter. Thor Eysteinsson1, S. B. Daníelsson1, A. García Llorca1, H. Reynisson1, M. H. Ogmundsdottir2, E. Steingrímsson2. 1Physiology, University of Iceland, Reykjavik, Iceland; 2Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland

5855 — C0142 Fluorescence Lifetime Imaging Ophthalmoscopy of ex-vivo retinal pigment epithelium after selective laser irradiation. Yoko Miura1, 2, A. Hutfilz1, B. Lewke1, C. Coelius2, S. Grisanti2, R. Brinkmann1, 3. 1Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany; 2Department of Ophthalmology, University of Lübeck, Lübeck, Germany; 3Medical Laser Center Lübeck, Lübeck, Germany

5856 — C0143 Measuring Short Wavelength and Near Infrared Fundus Autofluorescence in the presence of ABCA4 Mutations and Albinism. Janet R. Sparrow, M. Paavo, H. Kim, J. Zhao, W. Lee, R. Allikmets, S. H. Tsang. Department of Ophthalmology, Columbia University, New York, NY

5857 — C0144 Fluorophore Hyperspectral Signatures and Distribution in Canine Best Disease Compared to Analogous Fluorophores in Humans. Taariq Mohammed1, Y. Tong2, T. Ach4, M. Hammer5, R. Smith2, K. E. Guziewicz3. 1Ophthalmology, New York University School of Medicine, New York, NY; 2New York Eye and Ear Infirmary, New York, NY; 3School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Ophthalmology, University Hospital Würzburg, Würzburg, Germany; 5Department of Opthalmology, University of Jena, Jena, Germany

5858 — C0145 The hyperspectral autofluorescence (AF) differentiation of lipofuscin in the RPE and vitelliform debris of canine bestrophinopathy. Yuehong Tong1, T. Mohammed2, N. Dey3, T. Ach4, M. Hammer5, R. Smith1, K. E. Guziewicz6. 1Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY; 2Ophthalmology, New York University School of Medicine, New York, NY; 3Computer Science & Engineering, New York University, New York, NY; 4Ophthalmology, University Hospital Würzburg, Würzburg, Germany; 5Ophthalmology, University of Jena, Jena, Germany; 6School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA



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Thursday, May 03, 2018 8:15 AM-10:00 AMMultidisciplinary Ophthalmic Imaging Group

522 Innovations in Imaging

Moderators: Mahnaz Shahidi and Yan Li

5859 — C0146 Development of a binocular video-ophthalmoscope to compare parameters of heart beat induced blood volume changes between both eyes. Ralf P. Tornow1, F. Horn1, J. Odstrcilik2, R. Kolar2. 1Augenklinik, Universitaetsklinikum Erlangen, Erlangen, Germany; 2Department of Biomedical Engineering, Brno University of Techniology, Brno, Czechia *CR, f

5860 — C0147 Fluorescence Lifetime Imaging Ophthalmoscopy in early Alzheimer’s disease. Soonil Kwon1, 2, W. Fang2, E. Borreli2, A. Ebraheem2, K. Marion2, Y. Katayama4, S. R. Sadda2, 3. 1ophthalmology, Hallym Sacred Heart hospital, Anyang, Gyeonggi-do, Korea (the Republic of); 2Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA; 3ophthalmology, David Geffen School of Medicine at UCLA, Stein Eye Institute, Los Angeles, CA; 4Engineering GmbH, Heidelberg, Germany*CR

5861 — C0148 Holographic laser Doppler retinal imaging. Leo Puyo1, M. Paques2, M. Fink1, J. A. Sahel2, M. Atlan1. 1ESPCI - Institut Langevin, Paris, France; 2Institut de la Vision, Paris, France

5862 — C0149 Holographic line field en-face OCT with digital aberration correction in the human retina in-vivo. Laurin G. Ginner1, T. Schmoll2, A. Kumar1, M. Salas1, N. Pricoupenko1, L. Wurster1, R. Leitgeb1. 1ZMPBMT, Medical University of Vienna, Wien, Austria; 2Carl Zeiss Meditec, Dublin, CA

5863 — C0150 Blood flow quantification in retinal vessels by three-channel Doppler OCT with variable beam switching patterns. Christoph K. Hitzenberger, A. Wartak, F. Beer, B. Baumann, M. Pircher. Center F Med Physics & Biomed Eng, Medical University of Vienna, Vienna, Austria

5864 — C0151 In-vivo holographic imaging and reconstruction of the human eye. Marwan Suheimat1, A. J. Lambert2, D. A. Atchison1. 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; 2School of Engineering and Information Technology, University of New South Wales, Canberra, Canberra, Australian Capital Territory, Australia

5865 — C0152 Hyperspectral fundus camera with sensitivity beyond the visible range: a pilot study. Tommaso Alterini, F. Díaz-Doutón, M. Vilaseca. Centre for Sensors, Instruments and Systems Development (CD6), Universitat Politècnica de Catalunya (UPC), Terrassa, Barcelona, Spain

5866 — C0153 Imaging the human iris: a hyperspectral approach. Luca Di Cecilia, F. Marazzi, L. Rovati. Dept. of Engineering “E. Ferrari”, University of Modena and Reggio Emilia, Modena, Modena, Italy

5867 — C0154 Trabecular meshwork detection in automated gonioscopy. Simone Pajaro, L. Cappellari, A. De Giusti, A. Paviotti. R&D, NIDEK Technologies Srl, Albignasego, Padova, Italy*CR

5868 — C0155 Irido-corneal angle visualization in automated gonioscopy. Mauro Campigotto, A. Paviotti, A. De Giusti, L. Cappellari. Research & Development, NIDEK Technologies Srl, Albignasego (PD), Italy *CR

5869 — C0156 Handheld Adaptive Optics Scanning Laser Ophthalmoscope for in vivo Photoreceptor Imaging of Supine Adults and Neonates. Theodore DuBose1, D. Nankivil1, 3, F. LaRocca1, K. Hagan1, G. Waterman1, D. Tran-Viet2, A. N. Kuo2, 1, C. A. Toth2, 1, J. A. Izatt1, 2, S. Farsiu1, 2. 1Biomedical Engineering, Duke University, Durham, NC; 2Ophthalmology, Duke University Eye Center, Durham, NC; 3Johnson & Johnson Vision Care, Inc., Jacksonville, FL *CR

5870 — C0157 Characterizing retinal radiant exposure of line illumination. Yuan Liu, K. O’Hara, Y. WANG, N. Shemonski, J. Straub, C. Campbell. Carl Zeiss Meditec, Inc., Dublin, CA *CR

5871 — C0158 Non-mydriatic wide field fundus camera with flexible shape field of view. Meinert Jordan1, P. Voigtmann4, G. Michelson2, 3, B. Schmauss1. 1Institute of Microwaves and Photonics, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany; 2Department of Opthalmology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany; 3Talkingeyes&More GmbH, Erlangen, Germany; 4Voigtmann GmbH, Nuremberg, Germany *CR

5872 — C0159 Optical Design of Ultra-Wide-angle Fundus Imaging Device Using Four-color Lasers. Koichi Ito1, N. Honda2, H. Nakanishi2, M. Hanebuchi1, N. Isogai2. 1Advanced Technology Development Dept., Eye Care Div., NIDEK Co., Ltd., Gamagori, Aichi, Japan; 2Medical Development Dept., Eye Care Div., NIDEK Co., Ltd., Gamagori, Aichi, Japan *CR

5873 — C0160 Ocular blood flow imaging and quantification. Mircea Mujat, Y. Zhao, N. Iftimia, R. D. Ferguson. Physical Sciences Inc., Acton, MA *CR

5874 — C0161 Ultrafast Scanning Laser Ophthalmoscope for retinal tracking and on-line correction of the eye motion artifacts. Maciej Szkulmowski1, M. Nowakowski2, K. Dalasinski2, M. M. Bartuzel1, 3, K. Wrobel1, S. Tamborski1, E. Pijewska1, A. Szkulmowska2. 1Institute of Physics, Nicolaus Copernicus Univ, Torun, Poland; 2AM2M Ltd. L.P., Torun, Poland; 3Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland *CR

5875 — C0162 The use of TeraHertz scanning system as a new quantitative tool in corneal edema. Yu-Chi Liu1, 2, L. Ke3, N. Zhang3, H. Liu3, E. Teo1, J. Mehta2. 1Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore; 2Singapore National Eye Center, Singapore, Singapore; 3Institute of Materials Research and Engineering, Singapore, Singapore

5876 — C0163 Phase imaging of retinal cells for clinical studies and diagnosis. Timothé Laforest1, D. Carpentras1, M. Künzi1, L. Kowalczuk2, 3, F. F. Behar-Cohen3, 4, C. Moser1. 1LAPD, EPFL, Lausanne, Switzerland; 2Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; 3Fondation Asile des aveugles, Jules Gonin eye hospital, Lausanne, Switzerland; 4Centre de Recherche des Cordeliers, INSERM UMRS1138 Team17, Paris, France

5877 — C0164 Sodium (23Na) In Vivo Magnetic Resonance Imaging of the Human Eye at 7.0 Tesla: a New Tool to Investigate Ocular Disorders. Daniel Wenz1, O. Stachs2, A. Kuehne3, T. Huelnhagen1, A. M. Nagel4, 5, H. Waiczies3, E. Seeliger6, B. Flemming6, T. Niendorf1, 3. 1Berlin Ultrahigh Field Facility, Max Delbrueck Centrum, Berlin, Germany; 2Department of Ophthalmology, University Medical Center, Rostock, Germany; 3MRI.TOOLS GmbH, Berlin, Germany; 4Institute of Radiology, University Hospital Erlangen, Erlangen, Germany; 5Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 6Institute of Physiology, Charite University Medicine, Berlin, Germany *CR

5879 — C0165 Visualizing Retinal and Choroidal Blood Flow Noninvasively. Paras Vora, N. Bell, J. Cho, G. Botzet, R. Albuquerque. University of Kentucky, Lexington, KY

5878 — C0166 Non-invasive, non-mydriatic imaging of retinal blood flow over multiple fields of view. Abhishek Rege1, Y. Liu1, Y. Jing1, J. Howarth1, O. Saeedi2. 1Vasoptic Medical Inc, Baltimore, MD; 2Department of Ophthalmology and Visual Sciences, University of Maryland Baltimore, Baltimore, MD *CR

5880 — C0167 Fundus Flavoprotein Autofluorescence in Compressive Optic Neuropathy. Katie Topping1, 2, K. Cockerham1, A. Kossler1. 1Ophthalmology, Stanford University, Mountain View, CA; 2Ophthalmology, United States Navy, San Diego, CA

5881 — C0168 Dynamic Near-Infrared Imaging of Vitreous Opacities. Jorge Fortun, A. Nadelson, L. J. Haddock. Department of Ophthalmology, Bascom Palmer Eye Institute, University of MIami Miller School of Medicine, Palm Beach Gardens, FL *CR


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5882 — C0169 Assessment of retinal biomechanical properties under prosthetic electrode using ultrasonic micro-elastography. Xuejun Qian2, 3, T. LIN2, K. Shung3, M. S. Humayun2, 3, Q. Zhou2, 1. 1University of Southern California, Los Angeles, CA; 2USC Roski Eye Institute, University of Southern California, Los Angeles, CA; 3Department of Biomedical Engineering, University of Southern California, Los Angeles, CA

5883 — C0170 Evaluation of self stabilizing goniolens for intraoperative gonioscopy during microstent glaucoma procedures. K V Chalam, H. Dhalla, S. Russo. Univ of Florida-Jacksonville, Jacksonville, FL


Thursday, May 03, 2018 8:15 AM-10:00 AMGlaucoma

523 Imaging: Anterior Segment

Moderators: Sayoko E. Moroi and Benjamin Xu

5884 — C0171 Methods of analyzing chromatic pupillometry in glaucoma. Werner Eisenbarth1, A. Kwiatkowski1, N. Feucht2, L. Reznicek2, C. P. Lohmann2. 1Munich Center for Applied Vision Science, Munich University of Applied Sciences, Munich, Germany; 2Augenklinik und Poliklinik des Klinikum rechts der Isar der TU München, TU München, Munich, Germany

5885 — C0172 Post-phacoemulsification iris changes in glaucomatous and nonglaucomatous eyes. Qinyun Wang, Y. C. Hsia, C. I. Perez, M. Feinstein, M. Masis, M. Mora, S. C. Lin. Ophthalmology, University of California, San Francisco, San Francisco, CA

5886 — C0173 Interplicata distance as part of ciliary body biometry to understand complications of plateau iris configuration. Xiaofei MAN1, D. M. Reed2, J. Queen3, B. Ayres2, S. Moroi2. 1Ophthalomology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; 3Ophthalmology, Houston Methodist, Houston, TX

5887 — C0174 The Association of Ocular Surface Disease with Quality of Life in Patients with Glaucoma. Jenifer S. Wu, L. F. Machado, R. Portela, N. T. Fares, A. F. Leão, A. Paranhos, T. S. Prata, C. P. Gracitelli. Ophthalmology and Visual Science, Federal University of São Paulo, São Paulo, São Paulo, Brazil

5888 — C0175 Influence of Music on Intraocular Pressure and Morphology of Schlemm’s Canal: An SS-OCT Study. rouxi zhou, F. Li, Y. Yuan, X. Zhang. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center, Guangzhou, China

5889 — C0176 Evaluation of Ocular Surface Disease in Patients with Glaucoma: Clinical parameters, Self-report assessment and Keratograph Analysis. Renata Portela, N. T. Fares, D. Freitas, A. Paranhos, T. S. Prata, C. P. Gracitelli. Ophthalmology, UNIFESP, Sao Paulo, Sao Paulo, Brazil f

5890 — C0177 Effect of Preoperative Use of Steroid Eyedrops in Glaucoma Patient and its Outcomes after Trabeculectomy. Nikoly T. Fares, R. Portela, L. Machado, A. Paranhos, D. Freitas, C. P. Gracitelli. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo, São Paulo, Brazil

5891 — C0178 Corneal microstructure in suspects with glaucomatous optic disc appearance. Comparison with healthy subjects and glaucoma patients. D. Robert Iskander1, M. Majewska1, D. Jesus2, P. Krzyzanowska-Berkowska3. 1Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland; 2KU Leuven, Leuven, Belgium; 3Wroclaw Medical University, Wroclaw, Poland

5892 — C0179 Central Corneal Thickness Variances Among Different Asian Ethnicities In Glaucoma And Non-glaucoma Patients. Mai Badr, M. Masis, B. Amoozgar, A. Nguyen, S. C. Lin. University of California San Francisco (UCSF), San Francisco, CA

5893 — C0180 The relationship between adult height and ocular biometry in a Nepalese population: The Jiri Eye Study. Matthew P. Johnson1, S. Laston1, K. L. Anderson2, B. Towne3, J. Subedi4, J. Blangero1, S. Williams-Blangero1, S. S. Thapa5. 1South Texas Diabetes & Obesity Institute, School of Medicine, UTRGV, Brownsville, TX; 2Ophthalmology, School of Medicine, UT Health, San Antonio, TX; 3Population & Public Health Sciences, School of Medicine, Wright State Univ., Kettering, OH; 4Sociology & Gerontology, College of Arts & Science, Miami Univ., Oxford, OH; 5Tilganga Institute of Ophthalmology, Kathmandu, Nepal

5894 — C0181 The relationship between corneal hysteresis and progression of glaucoma after trabeculectomy. Yuri Fujino1, H. Murata1, M. Matsuura1, 2, R. Asaoka1. 1Tokyo Hospital, The University of Tokyo, Tokyo, Japan; 2Graduate school of Medical Science, Kitasato University, Kanagawa, Japan

5895 — C0182 In open angle glaucoma patients with diabetes mellitus longitudinal changes in central corneal thickness are associated with changes in optic nerve head morphology. David Camp1, A. Harris1, T. A. Ciulla5, A. Verticchio Vercellin3, 4, A. Shah1, P. Parekh1, M. Antheriou2, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2Ophthalmology, Universitary Hospitals of Geneva, Geneva, Switzerland; 3Glaucoma Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione G.B.Bietti, Rome, Italy; 4University Eye Clinic, Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Pavia, Italy; 5Retina Service, Midwest Eye Institute, Indianapolis, IN *CR

5896 — C0183 Correlations Between Anterior Segment Optical Coherence Tomography Parameters in Different Stages of Primary Angle Closure Disease. Jing Shan, A. A. Pardeshi, R. Varma, B. Xu. USC Roski Eye Institute, Los Angeles, CA

5897 — C0184 Anterior choroidal thickness increased in POAG and PACD eyes evidenced by UBM and SS-OCT. Xiulan Zhang, F. Li, K. Gao. Zhongshan Ophthalmic Center, the State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China

5898 — C0185&#tab; Biometric factors associated with acute primary angle closure: A comparison of the affected and eyes with a similar short axial length. Yoshiaki Kiuchi, Y. Shimizu, S. Nakakura, A. Noguchi, H. Tabuchi. Ophthalmology, Tsukazaki Hospital, Himeji, Japan *CR

5899 — C0186 A Novel Smartphone-Based Method for Quantitative Estimation of the Anterior Chamber Depth. Tanya Kowalski, E. Zamir. Centre for Eye Research Australia, Melbourne, Victoria, Australia

5900 — C0187 Angle and Ciliary Body Conformation in Anatomically Narrow Angle by Ultrasound Biomicroscopy. Suzanne Daly2, D. Coleman1, H. O. Lloyd1, R. H. Silverman1. 1Ophthalmology, Columbia University Medical Center, New York, NY; 2Ophthalmology, Columbia University Medical Center, NY, NY

5901 — C0188 Diagnostic sensitivity of Ultrasound Biomicroscopy (UBM) in identifying Clinical Aqueous Misdirection Syndrome. Mona Khurana5, R. Malik1, N. Saleh Al-Salameh2, A. E. Al-Garni4, A. Gaeed1, R. Philip5, S. Narasimhan5, R. J. George5, T. S. Vajaranant3, J. Wilensky3, D. P. Edward3. 1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2King Saud University, Riyadh, Saudi Arabia; 3University of Illinois Eye and Ear Infirmiry Chicago, Chicago, IL; 4King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 5Sankara Nethralaya Medical Research Foundation, Chennai, India



– 10:00 am

379


5902 — C0189 Assessment of circumferential angle closure with Swept-Source Optical Coherence Tomography: a community based study. Natalia Porporato1, B. Mani1, R. S. Ganguly2, T. A. Tun1, M. C. Tan3, J. H. Quah4, M. E. Nongpiur1, J. Allen2, C. Cheng1, T. Aung1. 1Glaucoma, Singapore Eye Research Institute, Singapore, Singapore; 2National University of Singapore, Singapore, Singapore; 3National University Hospital of Singapore, Singapore, Singapore; 4SingaHealth Polyclinic, Singapore, Singapore

5903 — C0190 Biomicroscopic Findings In Pseudoexfoliation Syndrome At Santa Casa De São Paulo Hospital. Joao Duvilio B Andreolli, N. Kasahara, R. Cohen. ISCMSP, Sao Paulo, Brazil

5904 — C0191 Comparison of anterior segment in nanophthalmic eyes with secondary chronic angle closure glaucoma and eyes with chronic primary angle closure glaucoma: an ultrasound biomicroscopy study. Zhongwen Li, Z. Zhao, J. Liu, J. Li, C. Guo, J. Zhang, D. Zhang, Z. Fan. Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China

5905 — C0192&#tab; Using a Novel Anterior Segment Optical Coherence Tomography (AS-OCT) Method to Assess Iridocorneal Angle. Mariana Nunez5, M. Y. Chen1, S. S. Lee2, C. Nien3, F. Medeiros4, J. L. Goldberg5. 1Ophthalmology, Allergan, Irvine, CA; 2Ophthalmology, Allergan, Irvine, CA; 3Ophthalmology, Allergan, Irvine, CA; 4Ophthalmology, Duke University, Durham, NC; 5Ophthalmology, Byers Eye Institute at Stanford, Palo Alto, CA *CR

5906 — C0193 Imaging Techniques for Trabecular Microbypass Stent (TMS). Carson Schell, S. Reich, J. Ellant, S. L. Thomas, E. Moriarty, E. Simpson, F. Kremer, J. B. Serle. Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY *CR

5907 — C0194 Collector Channel Dynamics: OCT Capture of Real-time Pressure-dependent Changes in Lumen Area in Ex Vivo Normal and Glaucomatous Eyes. Murray A. Johnstone1, C. R. Ethier2, 4, T. S. Acott3, J. Vranka3, S. J. Padilla1, K. Wen1, C. Xin5, 6, L. Zhang5, S. SONG5, R. K. Wang5, 1. 1Department of Ophthalmology, University of Washington, Seattle, WA; 2Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 3Department of Ophthalmology, Casey Eye Institute, Portland, OR; 4George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA; 5Department of Bioengineering, University of Washington, Seattle, WA; 6Department of Ophthalmology, Beijing Tongren Hospital/Capital Medical University, Beijing, Beijing, China

5908 — C0195 Imaging distal aqueous outflow pathways in a Spontaneous Model of Primary Congenital Glaucoma (PCG). Gillian J. McLellan1, K. Snyder1, K. Oikawa1, J. A. Kiland1, S. Gehrke1, A. Huang2. 1University of Wisconsin-Madison, Madison, WI; 2Ophthalmology, University of California, Los Angeles, Pasadena, CA *CR

5909 — C0196 Neuro-scleral Canal Size in Veterans with and without Glaucoma. Jake Hillard1, 2. 1Veterans Health Administration, Veterans Affairs, Boston, MA; 2New England College of Optometry, Boston, MA

5910 — C0197 A deep Learning Algorithm to Automatically segment the trabecular meshwork from anterior segment optical coherence tomography images. Baskaran Mani1, 2, X. Wang3, P. Hung3, t. a. tun1, 3, T. Aung4, 1, M. J. Girard3, 1. 1Glaucoma, Singapore Eye Research Institute, Singapore, Singapore; 2EYE ACP, Duke NUS graduate School, Singapore, Singapore; 3Dept of Bioengineering, National University of Singapore, Singapore, Singapore; 4Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

5911 — C0198 Effect of Prostaglandin Analogues on Anterior Choroid Thickness in Untreated Primary Open Angle Glaucoma: An SS-OCT Study. Kai Gao, F. Li, Y. Yuan, R. Zhou, Y. Sun, X. Zhang. Glaucoma, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, Guangzhou, China

5912 — C0199 Effect of Topical Trehalose/Hyaluronic Acid on OCT Image Quality in Glaucoma Patients. Eduardo M. Normando3, 2, C. Blackwell2, M. Cordeiro1, 3. 1Visual Neuroscience, UCL Institute of Ophthalmology, London, England, United Kingdom; 2Western Eye Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom; 3ICORG, Imperial College London, London, United Kingdom


Thursday, May 03, 2018 8:15 AM-10:00 AMRetina

523a Vitreoretinal Surgery: Novel Approaches

Moderators: T Michael Nork and Peter L. Gehlbach

5913 — C0310 The effect of distracting elements on surgical performance in a validated training program in vitreoretinal virtual reality surgery. Anna Stage Vergmann, A. H. Vestergaard, J. Grauslund. Department of Ophthalmology, Odense University Hospital, Odense C, Denmark f

5914 — C0311 Long-term outcomes of lamellar macular hole surgery using LHEP. Kosuke Takahashi1, Y. Morizane1, S. Kimura1, M. Hosokawa1, Y. Shiode1, M. Hirano1, S. Doi1, S. Toshima1, M. Hosogi1, Y. Kanzaki1, A. Fujiwara1, I. Takasu2, F. Shiraga1. 1Okayama University, Okayama, Japan; 2Takasu Eye Clinic, Okayama, Japan

5915 — C0312 Very Low-Pressure Subretinal Injection with Internal Limiting Membrane Removal Preserves Retinal Microstructure in Macaque Eyes. Shinji Toshima1, K. Takahashi1, Y. Morizane1, T. Hisatomi2, T. Tachibana2, S. Kimura1, M. Hosokawa1, Y. Shiode1, M. Hirano1, S. Doi1, M. Hosogi1, Y. Kanzaki1, A. Fujiwara1, K. Sonoda2, F. Shiraga1. 1Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

5916 — C0313 Low versus Standard Latency Digital 3D Monitor Visualization for Ophthalmic Surgery. William R. Freeman, K. Chen, D. Chao, H. Ferreyra, E. Nudleman, D. G. Bartsch. Ophthalmology, UCSD Jacobs Retina Ctr, UCSD Shiley Eye Institute, La Jolla, CA *CR

5917 — C0314 Intra-ocular diathermy forceps: first study in human subjects. Koen A. van Overdam1, 2, J. Pawiroredjo3, D. Jiawan3, S. Manning4. 1Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, Netherlands; 2The Rotterdam Ophthalmic Institute, Rotterdam, Netherlands; 3Suriname Eye Centre, Academic Hospital Paramaribo, Paramaribo, Suriname; 4Department of Ophthalmology, University Hospital Waterford, Waterford, Ireland *CR

5918 — C0315 Controlled injection pressure prevents damage during subretinal injections in pigs. Liva Spindler2, 3, M. Alberti2, 1, N. Sorensen2, 1, A. T. Christiansen2, 1, T. W. Kjær2, 3, S. Heegaard2, 1, J. F. Kiilgaard2, 1. 1Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Denmark, Copenhagen, Denmark; 2University of Copenhagen, Copenhagen, Denmark; 3Department of Neurology, Zealand University Hospital, Roskilde, Denmark

5919 — C0316 Endoscopy-assisted ciliary body membrane peeling is an effective treatment for hypotony secondary to rhegmatogenous retinal detachment repair. Rachel Tandias1, P. Sun1, 2, L. Campo1, J. Campo1, J. G. Arroyo1. 1Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 2Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China

5920 — C0317 OCT guided femtosecond laser treatment of vitreous floaters: A safety study. Georg Schuele1, J. Wang1, D. Dewey1, P. Gooding1, M. Wiltberger1, P. Monahan2, A. Vankov1. 1Johnson & Johnson Vision, Milpitas, CA; 2Retinal Diagnostic Center, Campbell, CA *CR


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5921 — C0318 Combined Femtosecond Laser-Assisted Cataract Surgery and Small-Gauge Pars Plana Vitrectomy Using Different Devices: A New Trend for Vitreoretinal Surgery? Bruno Q. Alves1, O. F. Brasil1, C. T. Espinhosa1, R. M. Japiassu1, M. B. Gonçalves1, O. M. Júnior1, A. Maia1, E. B. Cardoso1, P. Serraino2, A. Alezzandrinni2, M. Maia1. 1Ophthalmology, Federal University os São Paulo, São Paulo, SP, Brazil; 2University of Buenos Aires, Buenos Aires, Argentina

5922 — C0319 Inverted Internal Limiting Membrane flap peeling technique for large macular holes: 6-month results. Giulia Airaghi, E. Medda, G. D’Amico Ricci, E. Giancipoli, F. Boscia, A. Pinna. Department of Surgical, Microsurgical, and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari, Italy

5923 — C0320 Intraocular biocompatibility evaluation of thermogelling as a vitreous tamponade agent in rabbits. Zengping Liu1, X. Su1, 2, S. Liow3, M. Tan3, Z. Li3, X. Loh3, C. Chee1, G. Lingam1, 4. 1Ophthalmology, National University of Singapore, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore, Singapore; 3Institute of Materials Research and Engineering, A*Star (Agency for Science, Technology and Research), Singapore, Singapore; 4Medical Research Foundation, Chennai, India

5924 — C0321 HULC study (Heads Up Learning Curve): 3D Visualization system learning curve. Laurent Velasque1, M. Dominguez1, E. Fourmaux1, L. Rosier1, C. Seguy1, M. Lapeyre1, 2. 1Retine Gallien, Bordeaux, France; 2Chu Bordeaux, Bordeaux, France

5925 — C0322 Computational Fluidic Dynamics (CFD) modeling of a novel vitreous liquifier. Brian McCary1, O. B. Basaran3, V. Kolesnitchenko2. 1R+D, Bausch + Lomb, St. Louis, MO; 2Medical Affairs, Bausch + Lomb, Irvine, CA; 3Purdue Universty, West Laffeyette, IN *CR

5926 — C0323 Quantitative Evaluation of Tool-to-Sclera Forces, in a Model of Retinal Microsurgery. Marina Roizenblatt, A. Ebrahimi, C. He, N. Patel, I. Iordachita, P. L. Gehlbach. Johns Hopkins University, Baltimore, MD

5927 — C0324 Emulsification of silicone oil (SiO) tamponade with high-molecular-weight (HMW) additive under simulated saccadic eye movements in vitro using an“Eye-on-a-Chip”. Yau Kei Chan1, 2, Y. Lu1, D. Wong3, 2, H. Shum1. 1Mechanical Engineering, University of Hong Kong, Hong Kong, Hong Kong; 2Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; 3St. Paul’s Eye Unit, The Royal Liverpool University Hospital, Liverpool, United Kingdom *CR

5928 — C0325 Allogenic anterior capsular flap transplantation in the management of refractory macular holes. Peiquan Zhao1, H. Jin1, J. Peng1, H. Zhang2. 1Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China; 2Ophthalmology, Binzhou Hubin Aier Eye Hospital, Binzhou, Shanghai, China

5929 — C0326 Development of Minipigs Surgical Model: Cauterization of the Choroid Following Scleral Dissection Mitigates Risk of Post-Operative Vitreous Hemorrhage Following Ocular Implantation of RPDS. Vladimir Bantseev1, G. Barteselli1, C. Schuetz1, J. Horvath1, K. Hovaten1, S. R. Erickson1, J. M. Stewart2, E. Bentley3, P. E. Miller3, B. Dwyer4, J. J. Prusakiewicz4, T. M. Nork3, H. S. Booler1. 1Genentech Inc., South San Francisco, CA; 2Ophthalmology, University of California, San Francisco, San Francisco, CA; 3Ocular Services On Demand, Madison, WI; 4Covance Laboratories Inc., Madison, WI *CR

5930 — C0327 Evaluation of OCT versus surgeon guided robotic manipulation in a simulated vitreoretinal model. Saskia van Romunde1, K. Faridpooya1, K. A. Vermeer1, M. D. De Smet2, G. Naus2, M. Beelen2, T. Meenink2, M. Cereda3, A. Giani3, J. C. van Meurs1. 1Eye Hospital Rotterdam, Rotterdam, Netherlands; 2Preceyes, Eindhoven, Netherlands; 3Ospedale Sacco, Milan, Italy *CR

5931 — C0328 Hyaluronic acid based cross-linked hydrogels – a biosafe, sufficient tamponade of the vitreous body. Lisa K. Pohl1, K. Januschowski1, 2, S. Schnichels1, J. Hurst1, C. Hohenadl4, C. Reither4, M. S. Spitzer1, 3. 1Center of Ophthalmology, University Hospital Tübingen, Tübingen, Germany; 2Augenklinik Sulzbach, Sulzbach, Germany; 3University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 4Croma-Pharma GmbH, Leobendorf, Austria *CR

5932 — C0329 Thermal Effects of VitesseTM Hypersonic Vitrector during Simulated Surgery. Nicole Bergmann1, B. McCary1, V. Kolesnitchenko2, A. Pilon3. 1R&D, Bausch + Lomb, St. Louis, MO; 2Medical Affairs, Bausch + Lomb, Irvine, CA; 3Surgical, Bausch + Lomb, Irvine, CA *CR

5933 — C0330 Successful use of a silicone lacrimal plug to treat a case of refractory serous macular detachment complicating a large optic disk pit. Jean-Baptiste Deltour, O. Lebreton, H. Masse, M. Weber. Ophthalmology, Centre Hospitalier Universitaire de Nantes, Nantes, France

5934 — C0331 Comparison of Relative and Threshold Flow Rates for Vitreous Removal Between Two Vitrectomy Removal Techniques: Guillotine-Based Cleavage versus Open-Port, Hypersonic Liquification. Valeri Kolesnitchenko1, N. Bergmann2, B. McCary2, L. Barr2, A. Pilon3. 1Medical Affairs, Bausch + Lomb, Irvine, CA; 2R&D, Bausch + Lomb, St. Louis, MO; 3Surgical, Bausch + Lomb, Irvine, CA *CR

5935 — C0332 Improved 27-Gauge Flow Performance of Dual-Pneumatic 10,000 cpm Cutters. Dina Joy Abulon1, I. Mohamedy2, H. Gariepy2. 1Clinical Development and Medical Affairs, Alcon, Lake Forest, CA; 2Alcon, Lake Forest, CA *CR

5936 — C0333 A first-in-man trial assessing robotic surgery inside the human eye to perform a subretinal injection. Thomas L. Edwards1, K. Xue1, T. Meenink2, M. Beelen2, G. Naus1, M. P. Simunovic1, M. Latasiewicz4, A. Farmery3, M. D. De Smet2, R. E. MacLaren1. 1Nuffield Laboratory of Ophthalmology, University of Oxford, East Melbourne, Victoria, Australia; 2Technical University of Eindhoven, Eindhoven, Netherlands; 3Nuffield Department of Anaesthesia, Oxford, United Kingdom; 4Oxford Eye Hospital, Oxford, United Kingdom *CR, f

5937 — C0334 A Model to Study Thermal Energy Delivery to the Choroid: A Comparison of Surgical Devices. Stephen A. LoBue2, 1, P. Tailor4, P. Loftness3, T. W. Olsen2, 1. 1Ophthalmology, Mayo Clinic Rochester, MN, Rochester, MN; 2Ophthalmology, Emory School of Medicine, Atlanta, GA; 3University of Minnesota, Minneapolis, MN; 4Medical College of Georgia, Augusta, GA *CR

5938 — C0335 Modified Sutured Intraocular Lens Technique: Description and Case Series of Early Results. Mark Barakat. Retinal Consultants of Arizona, Phoenix, AZ

5939 — C0336 Syringe adapter for intraocular injection with stabilized grip position. M. Ali Nasseri, M. Zhou, M. Maier, C. P. Lohmann. Ophthalmology, Klinikum rechts der Isar, TUMuenchen, Muenchen, Germany

5940 — C0337 Jointing Macular Hole Edges Centripetally by Internal Limiting Membrane -Retina Adhesive Forces: A Novel Technique for Macular Holes. Jie Peng, P. Zhao. Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

5941 — C0338 Developing a retinal detachment model for in vivo testing of vitreous substitutes with repeated pars plana vitrectomy. Henrik Barth1, S. W. Crafoord2, F. K. Ghosh1. 1Department of Ophthalmology, Lund University Hospital, Lund, Sweden; 2Department of Ophthalmology, Örebro University Hospital, School of Health and Medical Sciences, Örebro University, Örebro, Sweden

5942 — C0339 23-Gauge BSS Flow of Dual-Pneumatic 10,000cpm Vitrectomy Probes. Helaine Gariepy1, I. Mohamedy2, D. Abulon1. 1Global Medical Affairs, Alcon Laboratories Inc., Lake Forest, CA; 2Alcon Laboratories Inc., Lake Forest, CA

5943 — C0340 Duty Cycle of 23-Gauge of Dual-Pneumatic 10,000cpm Vitrectomy Probes. Ishaq Scott Mohamedy1, H. Gariepy1, D. Abulon2. 1Alcon, Lake Forest, CA; 2Clinical Development and Medical Affairs, Alcon, Lake Forest, CA



– 10:00 am

381


5944 — C0341 Vitreous Traction Comparison of 27-Gauge High-Speed Dual-Pneumatic Vitrectomy Probes. Brian McDonell, H. Gariepy, D. Abulon. Alcon, Lake Forest, CA

5945 — C0342 Scleral Buckling For Severe Postraumatic Hypotony New Therapeutic Approach For Traumatic Ciliochoroidal Detachment Consequences. Eleonora Lavaque1, M. Iros2, A. Zambrano3. 1Retina, Hospital Oftalmologico Santa Lucia, Buenos Aires, Argentina; 2Instituto de Microcirugia Ocular Cordoba, Cordoba, Argentina; 3Fundación Zambrano, Buenos Aires, Argentina

5946 — C0343 Intraocular three pieces lens implantation device. carlos f. penaranda, L. Garcia Arzate, M. A. Beltran, V. Morales-Canton. Retina, asociacion para evitar la ceguera, Mexico, DF, Mexico *CR

5947 — C0344 The efficacy and safety of a novel posterior scleral reinforcement in the treatment of pathological myopia. Zequn Miao, L. Wang. Department of Ophthalmology, Eye diseases and optometry Institute, Peking University People’s Hospital, Beijing, China


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382The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/program-summary.

Room 301AB

Thursday, May 03, 2018 11:00 AM-12:45 PMImmunology/Microbiology

524 Advances in Clinical Therapeutics for Uveitis

Moderators: H Nida N. Sen and Justine R. Smith

5948 — 11:00 Efficacy of IL-12/23 inhibition for the Treatment of Active Sight-Threatening Uveitis: A Pilot Study. Lotta Utriainen, J. Lee, Z. Li, B. Chaon, I. Thompson, B. Chaigne-Delalande, H. N. Sen. National Eye Institute, NIH, Bethesda, MD f

5949 — 11:15 Posterior Segment Inflammatory Outcomes (Month-6) in the STOP-Uveitis Study: Evaluating the Safety, Tolerability, and Efficacy of Tocilizumab in Patients with Non-Infectious Uveitis. Mohammad A. Sadiq1, M. Hassan2, M. Halim2, R. Afridi2, D. V. Do2, Q. Nguyen2, Y. Sepah2, 3. 1. West Virginia University, Morgantown, WV; 2Byers Eye Institute, Stanford University, Palo Alto, CA; 3Ocular Imaging Research and Reading Center, Palo Alto, CA f

5950 — 11:30 Improvement in Macular Edema with Sarilumab in Non-infectious Uveitis (NIU): SATURN Trial. Diana V. Do. Stanford University School of Medicine, Palo Alto, CA *CR, f

5951 — 11:45 Long-Term Efficacy and Safety of Adalimumab by Immunosuppressant Use in Patients with Non-Infectious Uveitis in the VISUAL III Trial. Yan J. Guex-Crosier1, C. S. Foster2, 3, K. Nakai4, H. Goto5, K. Douglas6, S. Pathai7, M. Kron8, A. P. Song6, J. Van Calster9, A. Adan Civera10. 1Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland; 2Massachusetts Eye Research and Surgery Institution (MERSI), Ocular Immunology & Uveitis Foundation (OIUF), Waltham, ME; 3Harvard Medical School, Boston, ME; 4Yodogawa Christian Hospital, Osaka, Japan; 5Tokyo Medical University, Tokyo, Japan; 6AbbVie Inc, North Chicago, IL; 7AbbVie Ltd, Maidenhead, United Kingdom; 8AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany; 9University Hospitals Leuven, Leuven, Belgium; 10Hospital Clinic de Barcelona, Barcelona, Spain *CR, f

5952 — 12:00 Safety and Efficacy of an intravitreal 0.18 mg fluocinolone acetonide insert (FAi) for the treatment of non-infectious posterior segment uveitis (NIPU) – pooled results of two phase 3 trials. Eric B. Suhler. Casey Eye Institute-OHSU and VA Portland HCS, Portland, OR *CR, f

5953 — 12:15 Novel Dexamethasone Sodium Phosphate Treatment (DSP-Visulex) for Noninfectious Anterior Uveitis: Phase I/II, Double Masked, Randomized Study. Kongnara Papangkorn, J. W. Higuchi, B. Brar, W. I. Higuchi. Aciont Inc, Salt Lake City, UT *CR, f

Room 306AB

Thursday, May 03, 2018 11:00 AM-12:45 PMEye Movements/Strabismus/Amblyopia/ Neuro-Ophthalmology

525 Amblyopia

Moderators: Frank A. Proudlock and Eileen E. Birch

5954 — 11:00 Visual function and optical coherence tomography angiography features in children born preterm. Siva Balasubramanian1, 2, E. Borrelli1, M. Lonngi4, F. Velez2, 3, D. Sarraf2, 3, S. R. Sadda1, 2, I. Tsui1, 2. 1Doheny Eye Institute, Los Angeles, CA; 2Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 3Ophthalmology, Stein Eye Institute UCLA, Los Angeles, CA; 4Ophthalmology, Fundación Oftalmológica Nacional, Bogotá, Colombia *CR

5955 — 11:15 Spiking Noise in V2 Neurons in Infants Monkeys. Bin Zhang1, 2, Y. Wang2, X. Tao3, G. Shen3, J. M. Wensveen2, E. L. Smith2, Y. M. Chino2. 1College of Optometry, Nova Southeastern University, Plantation, FL; 2College of Optometry, University of Houston, Houston, TX; 3Baylor College of Medicine, Houston, TX

5956 — 11:30 EEG recordings during binocular rivalry reveals changes of binocular interaction following perceptual learning in adult amblyopia. Siyuan Deng1, L. Gu2, Z. Lu3, F. Hou4, Z. Chen1, Z. Chen1, M. Yu1, X. Wu2, J. Li1. 1State Key Laboratory of Ophthalmology, Guangdong Provincial Key Lab of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Psychology, Sun Yat-sen University, Guangzhou, Guangdong, China; 3Department of Psychology, The Ohio State University, Columbus, OH; 4School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China *CR

5957 — 11:45 Visual Sensory Deficits in Amblyopic Children with and without Latent Nystagmus. Fatema F. Ghasia, C. Gallagher. Ophthamology and visual science, Cole Eye Institute-Cleveland Clinic, Chagrin Falls, OH

5958 — 12:00 Attention is biased towards the fellow eye in strabismic amblyopia. Amy H. Chow1, D. Giaschi2, B. Thompson1. 1Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada; 2Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

5959 — 12:15 Impaired Fellow Eye Motion Perception in Amblyopic Children is Alleviated by Binocular Treatment. Eileen E. Birch1, 2, R. M. Jost1, Y. Wang1, 2, K. R. Kelly1, D. Giaschi3. 1Retina Foundation of the Southwest, Dallas, TX; 2Ophthalmology, UT Southwestern Medical Center, Dallas, TX; 3Psychology & Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada

5960 — 12:30 The acuity and crowding deficits in strabismic amblyopia are stronger in the fovea than the visual periphery. Alexandra V. Kalpadakis-Smith1, V. Tailor1, 2, A. H. Dahlmann-Noor2, D. Schwarzkopf3, 1, J. A. Greenwood1. 1Experimental Psychology, University College London, London, United Kingdom; 2NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 3School of Optometry and Vision Science, The University of Auckland, Auckland, New Zealand

Room 310

Thursday, May 03, 2018 11:00 AM-12:45 PMVisual Psychophysics/Physiological Optics / Visual Neuroscience

526 Visual psychophysics in color and complex vision

Moderators: Jay Neitz and John S. Werner

5961 — 11:00 S-cone inputs to midget retinal ganglion cells and their implications for color vision. Sara Patterson1, 3, J. Kuchenbecker3, A. Bordt2, C. M. Linehan3, J. R. Anderson4, D. W. Marshak2, M. Neitz3, J. Neitz3, M. B. Manookin3. 1Neuroscience Graduate Program, University of Washington, Seattle, WA; 2Neurobiology and Anatomy, University of Texas Health Science Center, Houston, TX; 3Ophthalmology, University of Washington, Seattle, WA; 4John Moran Eye Center, University of Utah Health Science Center, Salt Lake City, UT

5962 — 11:15 Color detection without hue perception. Alexandra Neitz, X. Jiang, S. Patterson, A. Doebley, M. Neitz, J. Neitz, R. Sabesan. University of Washington, Seattle, WA

5963 — 11:30 Prevalence of Color Vision Deficiency in Chinese 6-year-old Children. Mengmeng Wang, M. Zhang. Hebei Provincial Eye Hospital, Xingtai City, Hebei Province, China

5964 — 11:45 Shape discrimination hyperacuity robust to decreased retinal illuminance and induced optical degradation for achromatic and colour vision. Luis Garcia-Suarez, M. S. Mousavi-Jalali, M. Nelson. School of Health Professions, Plymouth University, Plymouth, Devon, United Kingdom

5948 – 5964 – Thursday – Papers/Minisymposia

Thursday Papers/M

inisymposia

11:00 am – 12:45 pm

383f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.

5965 — 12:00 Fast-paced videogame training improves balance under dynamic visual conditions in older adults. Allen M. Cheong1, H. Lam1, R. Li3, S. Leat2, W. Tsang1. 1The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; 2University of Waterloo, Waterloo, Ontario, Canada; 3University of California, Berkeley, Berkeley, CA f

5966 — 12:15 A novel experimental setup for induction and objective assessment of visual fatigue. Daniel Spiegel, E. Lim, B. Drobe. Essilor International, Singapore, Singapore *CR

5967 — 12:30 Study of photic phenomena sizes and subjective vision quality while virtually implanting different chromatic correcting intraocular lenses. Karsten Sperlich1, J. Schubert1, M. Gerlach2, V. Fuchs2, S. Bohn1, H. Stolz3, P. Marczuk2, R. F. Guthoff1, O. Stachs1. 1Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany; 2Carl Zeiss Meditec AG, Berlin, Germany; 3Institute of Physics, University of Rostock, Rostock, Germany *CR

Room 311

Thursday, May 03, 2018 11:00 AM-12:45 PMRetina

527 Retinal Vascular Diseases II

Moderators: Michael S. Ip and Catherine Egan

5968 — 11:00 Melatonin suppressed HIF-1α-VEGF pathway to induced retinal neovascularization and neuroglial dysfunction in an oxygen-induced retinopathy model. Xi Lu, Y. Xu, Y. Hu, S. Yu, C. Tsui, J. Li, X. Liang. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China

5969 — 11:15 Choroidal Changes after Suprachoroidal Injection of CLS-TA, Triamcinolone Acetonide Injectable Suspension, in Eyes with Macular Edema Secondary to Retinal Vein Occlusion. Alex Willoughby1, V. Vuong1, D. Cunefare2, S. Farsiu2, G. Noronha3, R. P. Danis4, G. Yiu1. 1Ophthalmology, UC Davis, Sacramento, CA; 2Duke University Biomedical Engineering, Durham, NC; 3Clearside Biomedical, Inc., Alpharetta, GA; 4Univ. Wisconsin- Madison, Madison, WI *CR

5970 — 11:30&#tab; Efficacy of bevacizumab and laser photocoagulation for preventing the recurrence of macular edema due to branch vein occlusion (BRVO). Arnaldo F. Bordon, N. S. Abujamra, B. C. Monteiro. Hospital Oftalmologico de Sorocaba, Miami, FL *CR, f

5971 — 11:45 SCORE2 Month 6 to Month 12 Results: 12 Month Outcomes of Treatment Change among Poor Responders at Month 6. Michael S. Ip1, 2, P. C. VanVeldhuisen3, I. U. Scott4, B. A. Blodi5, T. Ghuman6, C. W. Baker7, N. L. Oden3. 1Ophthalmology, University of California Los Angeles, Los Angeles, CA; 2Ophthalmology, Doheny Eye Institute, Los Angeles, CA; 3Emmes Corporation, Rockville, MD; 4Departments of Ophthalmology and Public Health Sciences, Penn State College of Medicine, Hershey, PA; 5Fundus Photograph Reading Center, The University of Wisconsin, Madison, WI; 6National Ophthalmic Research Institute, Fort Myers, FL; 7Paducah Retinal Center, Paducah, KY *CR, f

5972 — 12:00 Quantification of Optical Coherence Tomography Angiography Metrics and their Relationship to Visual Acuity in Eyes Treated with Plaque Radiotherapy for Uveal Melanoma. Kareem Sioufi, A. Obeid, V. Bekerman, S. R. Ferenczy, J. Hsu, C. L. Shields. Philadelphia, Wills Eye Hospital, Philadelphia, PA *CR

5973 — 12:15 Optical coherence tomography angiography analysis of collateral formation in branch vein occlusion supports a serial arrangement of retinal flow with the origin of venous outflow in the deep vascular complex. Belinda C. Leong1, K. Freund1, 6, D. Sarraf2, S. Garrity2, K. Vupparaboina3, K. K. Dansingani4, 5. 1Vitreous Retina Macula Consultants of New York, Brooklyn, NY; 2Stein Eye Institute, Los Angeles, CA; 3Surjana Center for Innovation, LV Prasad Eye Institute, Hyderabad, India; 4Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA; 5Moorfields Eye Hospital, London, United Kingdom; 6Ophthalmology, New York University, Manhattan, NY *CR

5974 — 12:30 The Association of Venous Malformations of Retina and Brain. Giulia Corradetti1, F. Pichi3, K. Freund2, A. Ciardella4, E. Abboud3, N. Ghazi3, C. Dackiw3, N. Choudhry5, 6, E. Cunha-Souza10, L. P. Cunha8, 9, J. Arevalo7, T. Liu7, A. Wenick7, G. Villarreal jr7, L. He7, D. Sarraf1. 1Ophthalmology, Stein Eye Institute, UCLA, Los Angeles, CA; 2Vitreous Retina Macula Consultants of New York, New York, NY; 3Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; 4Sant’Orsola-Malpighi Hospita, Bologna, Italy; 5Ophthalmology, Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, Ontario, Canada; 6Ophthalmology, Cleveland Clinic Canada, Toronto, Ontario, Canada; 7Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 8Department of Ophthalmology, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil; 9University of São Paulo Medical School, São Paulo, Brazil; 10University of Sao Paulo, Sao Paulo, Brazil

Room 312

Thursday, May 03, 2018 11:00 AM-12:45 PMCornea

528 Cornea Refractive Surgery

Moderators: Julie Schallhorn and Richard Y. Hida

5975 — 11:00 Aspheric Micro-monovision LASIK in Correction of Presbyopia and Myopic Astigmatism: Results after 3 Years in a Chinese Population. Fang Liu, T. Zhang, S. Weng, X. Yang, Q. Liu. refractive surgery, zhongshan Ophthalmic center, Guangzhou, Guangdong, China

5976 — 11:15 Photorefractive Keratectomy versus Laser in situ Keratomileusis for Hyperopia in 58,562 Eyes. Liuyang Li1, 2, J. M. Schallhorn1. 1University of California, San Francisco, California, USA, San Francisco, CA; 2Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China, Tianjin, China

5977 — 11:30 Quality of Vision After Wavefront-Guided or Wavefront-Optimized Photorefractive Keratectomy: A Prospective Randomized Contralateral Eye Study. Ryan Smith, E. E. Manche. Stanford Univeristy, Los Altos, CA *CR, f

5978 — 11:45 Patient-Reported Visual Symptoms after Refractive Lens Exchange. Kristin Hirabayashi1, J. M. Schallhorn1, S. Schallhorn1, 3, S. Hannan2. 1Ophthalmology, University of California, San Francisco, Burlingame, CA; 2Optical Express, Edinburgh, United Kingdom; 3Carl Zeiss Meditec, Inc., Dublin, CA *CR

5979 — 12:00 Long-term Outcomes of Femtosecond Laser-Assisted Small Incision Endokeratophakia Using a Xenogeneic Lenticule in Rhesus Monkeys. Miao He1, H. Ding2, W. Wang1, W. Huang1, X. Zhong1, 2. 1Zhongshan ophthalmic center, Sun Yat-sen University, Guangzhou, China; 2Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China

5980 — 12:15 Altered corneal stromal molecular profile associated with post-refractive ectasia. Pooja Khamar1, R. Shetty1, N. Kumar2, T. Vaidya2, M. Francis2, A. Sinha Roy3, S. Sethu2, A. Ghosh2. 1Narayana Netralaya, Ahmedabad, Gujarat, BIHAR, India; 2GROW laboratory, Narayana Nethralaya, Bengaluru, Karnataka, India; 3IBMS, Narayana Nethralaya, Bengaluru, Karnataka, India

5981 — 12:30 Analysis of Topography-Guided LASIK Treatment Planning Strategies. Ronald R. Krueger, V. S. De Stefano, C. Meister. Cole Eye Institute, Cleveland Clinic, Cleveland, OH *CR

Thursday – Papers/Minisymposia – 5965 – 5981

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Room 313A

Thursday, May 03, 2018 11:00 AM-12:45 PMAnatomy and Pathology/Oncology

529 Clinical Innovations in Oncology

Moderators: Colleen M. Cebulla, Vikas Khetan and Lauren A. Dalvin

5982 — 11:00 Chemoreduction with Topotecan and Vincristine: Clinical Validation of a Novel Chemotherapeutic Regimen for Bilateral Intraocular Retinoblastoma. Benjamin King1, 2, M. W. Wilson1, 2, R. C. Brennan3. 1Surgery, St. Jude Children’s Research Hospital, Memphis, TN; 2Ophthalmology, University of Tennessee Health Science Center, Memphis, TN; 3Oncology, St. Jude Children’s Research Hospital, Memphis, TN f

5983 — 11:15 Doppler-based angiography of retinoblastoma in diagnostic imaging of pediatric patients: clinical trials with a novel 1050nm OCT system. Oleg Nadiarnykh1, 2, V. Davidoiu1, M. G. Gräfe1, F. D. Verbraak3, M. B. [email protected], A. Moll3, J. De boer1. 1Physics, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; 2VU MC, Amsterdam, Netherlands; 3Vrije University Medical Center, Amsterdam, Netherlands *CR

5984 — 11:30 Vitreous Seed and Soil: Elevated Levels of Platelet-Derived Growth Factor (PDGF) in the Vitreous of Patients with Retinoblastoma. Zachary K. Goldsmith1, s. R. barsh1, K. Yuan1, B. King1, R. C. Brennan1, 2, M. W. Wilson1, 3, V. M. Morales-Tirado1, 4. 1Ophthalmology, University of Tennessee Health Science Center, Germantown, TN; 2Oncology, St. Jude Children’s Research Hospital, Memphis, TN; 3Surgery, St. Jude Children’s Research Hospital, Memphis, TN; 4Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN

5985 — 11:45 Recurrence prediction and usefulness of Mohs microscopic surgery in Chinese patients of eyelid sebaceous gland carcinoma: a retrospective cohort study of 238 patients. Chuandi Zhou, R. Jia, X. Fan. Ophthalmology, Ninth People’s Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China

5986 — 12:00 Orbital Lymphoma - An International Multicenter Retrospective Study. Tine Gadegaard G. Olsen1, P. Ramussen2, F. Holm1, L. H. Mikkelsen1, S. E. Coupland3, S. Heegaard1, 2. 1Department of Pathology, Rigshospitalet-Glostrup, Copenhagen, Denmark; 2Department of Ophthalmology, Rigshopitalet-Glostrup, Copenhagen, Denmark; 3Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, United Kingdom

5987 — 12:15 Ranibizumab for Radiation Retinopathy (RRR): A Prospective, Multicenter Trial of Monthly versus PRN Dosing for Radiation Retinopathy-Related Cystoid Macular Edema. Amy C. Schefler1, 2, D. Fuller3, R. Anand3, T. Fuller3, M. E. Bretana1, C. Cone1, C. Moore1, R. Kim1, 4. 1Ophthalmology, Retina Consultants of Houston, Houston, TX; 2Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX; 3Texas Retina Associates, Dallas, TX; 4University of Texas Houston, Houston, TX *CR, f

Room 314

Thursday, May 03, 2018 11:00 AM-12:45 PMVisual Neuroscience

530 Diseases and Protection

Moderators: Bang V. Bui and Rachael S. Allen

5988 — 11:00 An ultra light-sensitive CoChR mutant restores functional vison in a blind mouse model under ambient light conditions. Tushar H. Ganjawala1, Q. Lu1, M. D. Fenner1, G. W. Abrams2, Z. Pan2. 1Anatomy & Cell Biology, Wayne State University, Detroit, MI; 2Ophthalmology and Anatomy & Cell Biology, Wayne State University/Kresge Eye Institute, Detroit, MI *CR

5989 — 11:15 Chimeric human opsins as optogenetic light sensitizers. Doron Hickey2, 1, W. I. Davies2, 3, S. Hughes2, 5, J. Rodgers2, 4, N. Thavanesan2, R. E. MacLaren2, 56, M. W. Hankins2, 5. 1Royal Victorian Eye and Ear Hospital, Heidelberg, Victoria, Australia; 2Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom; 3School of Biological Sciences and UWA Oceans Institute, Perth, Western Australia, Australia; 4Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom; 5Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, United Kingdom; 6Oxford University Hospitals NHS Trust Biomedical Research Centre, Oxford, United Kingdom

5990 — 11:30 A Pathoconnectome of Early Retinal Remodeling. Rebecca Pfeiffer1, R. E. Marc1, J. R. Anderson1, D. P. Emrich1, C. B. Watt1, J. Yang1, K. D. Rapp1, J. Dahal1, M. Kondo2, H. Terasaki3, B. W. Jones1. 1Moran Eye Center/ Ophthalmology, University of Utah, Salt Lake City, UT; 2Mie University, Tsu, Japan; 3Nagoya University, Nagoya-shi, Japan *CR

5991 — 11:45 Early retinal and cerebral deficits in a high fat diet + low dose STZ rat model of Type II diabetes. Rachael S. Allen1, 2, A. Feola1, 2, K. C. Chesler1, 2, C. Motz1, M. M. Coulter1, P. M. Thule3, 4, J. H. Boatright1, 5, M. T. Pardue1, 2. 1Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA; 2Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 3Section Endocrinology and Metabolism, Atlanta VA Medical Center, Decatur, GA; 4Section Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA; 5Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

5992 — 12:00 Morphological changes to retinal ganglion cells in a murine model of Alzheimer’s disease. Vickie Wong1, C. T. Nguyen1, P. Jusuf2, J. K. Lim1, M. Tayebi3, B. V. Bui1. 1Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia; 2School of Biosciences, University of Melbourne, Parkville, Victoria, Australia; 3School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

5993 — 12:15 Morphometric Analysis of the Retinal Ganglion Cell and Inner Plexiform Layers in Alzheimer’s Disease: Biomarkers in the Eye for degeneration in the Brain. Samuel Asanad1, 2, F. N. Ross-Cisneros1, 2, E. Barron1, A. Golston3, E. A. Barron1, A. A. Sadun1, 2. 1Ophthalmology, Doheny Eye Institute - UCLA, Woodland Hills, CA; 2Ophthalmology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; 3Biostatistics, UCLA, Los Angeles, CA

5994 — 12:30 Retinal ganglion cell function in recovered optic neuritis is abnormally fast. Vittorio Porciatti, P. Monsalve, S. Ren, M. Kostic, P. Gordon, J. Wang, H. Jiang. Bascom Palmer Eye Inst, Univ of Miami Miller Sch Med, Miami, FL

Room 315

Thursday, May 03, 2018 11:00 AM-12:45 PMRetinal Cell Biology / Biochemistry/Molecular Biology / Retina

531 Retinal lipid and glucose metabolism in health and disease - Minisymposium

The retina is one of the most metabolically demanding tissues in the body. Fluctuating energy demands in the retinal neurons, glia, and vascular cells often require lipid as well as glucose metabolism for energy. The highly complex regulation of aerobic and anaerobic metabolism is beginning to be understood, and this mini-symposium will explore these pathways in various retinal cell types with in health and disease.

Moderator: Julia V. Busik

— 11:00 Introduction & Welcome


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5995 — 11:05 Retinal lipid and glucose metabolism dictates angiogenesis. Jean-Sebastien Joyal. Pediatrics and Pharmacology, University of Montreal, Montreal, Quebec, Canada

5996 — 11:20 Retinal oxygenation and metabolism in health and disease. Mahnaz Shahidi. Ophthalmology, University of Southern California, Los Angeles, CA *CR

5997 — 11:35 Protein synthesis and lipid metabolism as key pathogenic processes of retinal sensibility to diabetes. Patrice E. Fort1, 2. 1Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; 2Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI

5998 — 11:50 Oxidative stress and mitochondrial function in Müller cells. Miriam Kolko. Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

5999 — 12:05 Photoreceptor metabolic and redox signaling in health & disease. Thierry D. Leveillard. Institut De La Vision, Paris, France *CR

6000 — 12:20 Molecular mechanisms underpinning temporal and spatial energy demands of the retina. Jianhai Du1, 2. 1Ophthalmology, West Virginia University, Morgantown, WV; 2Biochemistry, West Virginia University, Morgantown, WV

— 12:35 Conclusion

Room 316A

Thursday, May 03, 2018 11:00 AM-12:45 PMPhysiology/Pharmacology

532 Retina III

Moderators: Matias Iglicki and Gustavo D. Aguirre

6001 — 11:00 Progression of Diabetic Retinopathy Severity after Treatment with Dexamethasone Implant – A 24-Month Cohort Study The ‘DR-Pro-DEX Study’. Matias Iglicki1, D. Zur2, C. Busch3, M. Okada4, A. Loewenstein2, 5. 1University of Buenos Aires, Caba, Argentina; 2Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel; 3Ophthalmology, Department of Ophthalmology, University of Leipzig, Germany, Leipzig, Germany; 4Royal Victorian Eye and Ear Hospital, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia, Melbourne, Victoria, Australia; 5Incumbent, Sydney A. Fox chair in Ophthalmology, Incumbent, Sydney A. Fox chair in Ophthalmology, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel

6002 — 11:15 Intermittent Fasting (IF) Prevents Development of Diabetic Retinopathy (DR) by regulating low-grade inflammation through changes in lipid metaobolism. Eleni Beli1, L. Moldovan2, Y. Duan3, S. Li Calzi5, C. Evans-Molina2, 1, J. V. Busik4, M. Grant5. 1Pediatrics, IUPUI, Indianapolis, IN; 2Medicine, VA Hospital, Indianapolis, IN; 3Physiology, IUPUI, Indianapolis, IN; 4Physiology, MSU, East Lansing, MI; 5Ophthalmology, UAB, Birmingham, AL

6003 — 11:30 Ocular Pharmacokinetics of Insulin-loaded Thermoresponsive Biodegradable Nanogels. Tao L. Lowe1, F. Sahle1, C. Fili2, D. Will1, S. Davison2, D. Hamilton2. 1Pharmaceutical Sciences, Univ of Tennessee Health Science Ctr, Memphis, TN; 2Comparative Medicine, University of Tennessee Health Science Center, Memphis, TN

6004 — 11:45 Drug delivery to the back of the eye using A minimally invasive adjustable-depth blunt injector. Ygal Rotenstreich2, 3, E. Bubis2, 3, Z. Goldberg2, 3, H. Ziv1, 3, S. Pri-Chen1, 3, I. Sher-Rosenthal2. 1Goldscheleger Eye Research Institute, Sheba Medical Center, Tel Hashomer, Israel; 2The Maurice and Gabriela Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 3The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel *CR

6005 — 12:00 Hydroxychloroquine enhances the efficacy of retinal gene therapy. Laurel C. Chandler1, 2, A. R. Barnard1, 2, M. I. Patrício1, 2, K. Xue1, 2, R. E. MacLaren1, 2. 1Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom; 2Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom *CR

6006 — 12:15 Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis. Gustavo D. Aguirre1, A. V. Cideciyan2, S. L. Boye3, S. Iwabe1, V. Dufour1, M. Swider2, K. Roszak1, W. W. Hauswirth3, S. G. Jacobson2, W. A. Beltran1. 1Clinical Studies, Univ of Penn Sch Veterinary Med, Philadelphia, PA; 2Ophthalmology, University of Pennsylvania, Philadelphia, PA; 3Ophthalmology, University of Florida, Gainesville, FL *CR

6007 — 12:30 Potential and pitfalls of intravitreal injected mRNA as ocular neuroprotection strategy. Katrien Remaut1, J. Devoldere1, L. De Groef2, K. Peynshaert1, H. Dewitte1, L. K. Moons2, S. De Smedt1. 1Lab General Biochem and Physical Pharm, Ghent University, Ghent, Belgium; 2Department of Biology, Ku Leuven, Leuven, Belgium

Room 316B

Thursday, May 03, 2018 11:00 AM-12:45 PMClinical/Epidemiologic Research

533 AMD Epidemiology and Treatment

Moderators: Tiarnan D. Keenan and Susan Vitale

6008 — 11:00 Exploring factors underlying ethnic differences in age-related macular degeneration (AMD) prevalence. Jie Jin Wang1, 2, M. Jones4, E. Holliday4, 3, A. G. Tan2, C. Oldmeadow4, R. M. van Dam5, X. Sim5, V. Flood6, 7, C. Whitton5, R. Klein8, Y. Teo5, P. Mitchell2, T. Y. Wong9, 10, E. Tai11, J. Attia4, 3. 1Centre for Clinician-Scientist Development, Duke-NUS Medical School, Singapore, Singapore, Singapore; 2Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia; 3School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia; 4Clinical Research Design and Stats Support Unit, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia; 5Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; 6Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia; 7Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia; 8Department of Ophthalmology & Visual Sciences, University of Wisconsin Medical School, Madison, WI; 9Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; 10Singapore National Eye Centre, Singapore, Singapore; 11Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

6009 — 11:15 Does cataract surgery (CSG) increase the risk of incident age-related macular degeneration (AMD)? Alfred Gan1, R. Man1, 2, E. Fenwick1, 2, C. Sabanayagam1, 2, P. Gupta1, Y. Tham1, J. Wang2, 4, N. Tan3, P. Mitchell4, G. Cheung1, 3, T. Wong1, 3, C. Cheng1, 2, E. L Lamoureux1, 2. 1Singapore Eye Research Institute, Singapore, Singapore; 2Duke-NUS Medical School, Singapore, Singapore; 3National University of Singapore, Singapore, Singapore; 4Centre for Vision Research, University of Sydney, Sydney, New South Wales, Australia


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6010 — 11:30 Geographic atrophy of age-related macular degeneration in the Age-Related Eye Disease Study 2 (AREDS2): incidence, clinical characteristics and factors influencing growth rate. Tiarnan D. Keenan1, 7, E. Agron1, A. Domalpally2, T. E. Clemons3, F. Van Asten4, W. T. Wong5, R. P. Danis2, M. L. Klein6, R. Ratnapriya4, A. Swaroop4, F. L. Ferris1, E. Y. Chew1. 1Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, MD; 2Fundus Photographic Reading Center, The University of Wisconsin, Madison, WI; 3The EMMES Corporation, Rockville, MD; 4Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, Bethesda, MD; 5Unit on Neuron-Glia Interactions in Retinal Disease (UNGIRD), National Eye Institute, Bethesda, MD; 6Devers Eye Institute, Portland, OR; 7Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom *CR, f

6011 — 11:45 The Characteristics of Geographic Atrophy From 25 Years of The Beaver Dam Eye Study (BDES). Stacy M. Meuer, K. E. Lee, B. E. Klein, R. Klein. Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI

6012 — 12:00 Smoking and the Clinical Features of Neovascular Age Related Macular Degeneration in a Clinic-Based Cohort. Nichole Joachim, P. Mitchell, G. Liew, G. Burlutsky, H. Dharamdasani, B. Gopinath. Centre for Vision Research, The University of Sydney, Westmead, New South Wales, Australia

6013 — 12:15 Visual acuity outcomes in eyes treated with anti-VEGF injections during the Age-Related Eye Disease Study 2 (AREDS2). Susan Vitale1, E. Agron1, T. Keenan1, T. E. Clemons2, E. Y. Chew1. 1Div Epidemiol & Clin Applications, National Eye Inst/NIH, Bethesda, MD; 2Emmes Corporation, Rockville, MD

Room 316C

Thursday, May 03, 2018 11:00 AM-12:45 PMLens

534 Cataract Surgery, epidemiology and clinical outcomes

Moderators: Leah Owen and Azin Abazari

6014 — 11:00 North of England Deprivation Study of Cataract presentation and outcomes. Alexander J. Silvester, R. Scott, A. Pitalia. Ophthalmology, SpaMedica, Bolton, United Kingdom

6015 — 11:15 Histopathological analysis of residual lens cells in capsular opacities after cataract surgery. Christina Mastromonaco1, M. Balazsi2, A. T. Dias1, D. Sanft1, J. M. Lasiste1, A. Cardillo1, J. J. Mansure3, M. N. Burnier1. 1MUHC Ocular Pathology Laboratory, Montreal, Quebec, Canada; 2Medical Parachute, Montreal, Quebec, Canada; 3McGill Urologic Oncology, Montreal, Quebec, Canada *CR

6016 — 11:30&#tab; Utility of Vision Index Pen in detecting early cataract and loss of accommodation. Azin Abazari1, H. Dhadwal2. 1Ophthalmology, Stony Brook University, Stony Brook, NY; 2Electrical and Computer Engineering, Stony Brook University, Stony Brook, NY *CR, f

6017 — 11:45 Cataract Surgery and Traffic Crashes: Population-based Exposure-Crossover Design. Matthew Schlenker1, 3, D. Thiruchelvam4, D. Redelmeier2, 4. 1Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 2Internal Medicine, Sunnybrook, Toronto, Ontario, Canada; 3Ophthalmology & Vision Sciences, Kensington Eye Institute, Toronto, Ontario, Canada; 4Institute of Clinical & Evaluative Sciences, Toronto, Ontario, Canada *CR

6018 — 12:00 Ultrastructural Changes in OCT and Refractive Differences after Refractive Lens Exchange Surgery. Chirag Shah1, D. Knight1, J. Tucker1, B. Cormier1, M. Wade1, S. Hannan2, S. Schallhorn3, M. C. Mehta1. 1Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA; 2Optical Express, Glasgow, United Kingdom; 3Carl Zeiss Meditec, Dublin, CA *CR

6019 — 12:15 Lens meridian position as a predictor of effective lens position. James Tucker, H. Muniz Castro, C. Shah, D. Knight, S. Garg, M. Farid, M. C. Mehta, M. Wade. Ophthalmology, University of California, Irvine, Orange, CA *CR

Room 320

Thursday, May 03, 2018 11:00 AM-12:45 PMBiochemistry/Molecular Biology

535 Genome: Structure, Function and Editing

Moderators: Ching-Kang J. Chen and Rajendra Kumar-Singh

6020 — 11:00 An AAV-CRISPR/Cas9 gene editing approach for GUCY2D-associated cone rod dystrophy (CORD6). Kevin Mccullough1, S. L. Boye1, D. Fajardo1, C. E. Strang2, D. C. Witherspoon2, S. Gloskowski3, A. Dass3, P. D. Gamlin2, M. Maeder3, S. E. Boye1. 1Ophthalmology, University of Florida, Gainesville, FL; 2University of Alabama Birmingham, Birmingham, AL; 3Editas Medicine, Inc., Cambridge, MA *CR

6021 — 11:15 Evaluating the long-term safety and efficacy of CRISPR ablation therapy for dominant retinitis pigmentosa by AAV-delivery. Benjamin Bakondi, B. Lu, S. Girman, C. Svendsen, S. Wang. Biomedical Sciences, Cedars-Sinai Regenerative Medicine Institute, Los Angeles, CA

6022 — 11:30 Functional genomics for inherited retinal diseases: characterizing variants of unknown significance in rhodopsin. Jason Comander, A. Wan, K. Wu, E. A. Pierce. Ocular Genomics Institute, Massachusetts Eye & Ear Infirmary, Boston, MA

6023 — 11:45 Identification of putative small open reading frame peptides in the retinal transcriptome. Lina Zelinger1, V. Chaitankar1, 2, J. Minehart1, A. Aponte3, A. Swaroop1. 1NNRL, National Eye Institute, Bethesda, MD; 2Bioinformatics and Computational Biology Core Facility, NHLBI, Bethesda, MD; 3Proteomics Core Facility, NHLBI, Bethesda, MD

6024 — 12:00 Distinct protective cell type-specific responses induced by chronic hypoxia in a mouse model of retinal hypovascularization revealed by single-cell RNAseq and metabolic profiling. Jacob S. Heng1, 3, A. Rattner1, H. J. Vernon2, B. W. Jones4, R. E. Marc4, L. A. Goff3, 2, J. Nathans1, 5. 1Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD; 2Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; 3Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; 4Ophthalmology, University of Utah, Salt Lake City, UT; 5Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD *CR

6025 — 12:15 Integrative functional genomics of age-related macular degeneration. Rinki Ratnapriya1, K. Sosina2, M. Starostik1, M. Kwicklis1, R. J. Kapphahn3, A. Walton1, A. Pietraszkiewicz1, S. R. Montezuma3, L. Fritsche5, E. Y. Chew4, G. R. Abecasis5, D. A. Ferrington3, N. Chatterjee2, A. Swaroop1. 1Neurobiol-Neurodegen & Repair Lab, National Eye Institute, NIH, Bethesda, MD; 2Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; 3Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN; 4Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, MD; 5Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI


Thursday Papers/M

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6026 — 12:30 CRISPR-derived mouse model of North Carolina Macular Dystrophy reveals in trans tissue-specific upregulation of PRDM13. Raquel S. Silva1, 2, K. Kraft2, 7, G. Arno1, 3, V. Heinrich4, N. Pontikos1, 3, V. Cipriani8, 3, B. Puech5, A. T. Moore6, 3, V. Van Heyningen1, 3, S. Mundlos2, 7, A. Webster1, 3. 1UCL Institute of Ophthalmology, London, United Kingdom; 2Development and Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany; 3Genetics, Moorfields Eye Hospital, London, United Kingdom; 4Department Vingron, Max Planck Institute for Molecular Genetics, Berlin, Germany; 5Exploration de la Vision et Neuro-Ophtalmologie, Centre Hospitalier Universitaire, Lille, France; 6Ophthalmology Department, UCSF School of Medicine, San Francisco, CA; 7Institute for Medical and Human Genetics, Charité Universitätsmedizin, Berlin, Germany; 8Queen Mary University, London, United Kingdom

Ballroom A

Thursday, May 03, 2018 11:00 AM-12:45 PMGlaucoma

536 Visual Fields, Vision Function, Psychophysics

Moderators: Allison M. McKendrick and Tobias Elze

6027 — 11:00 Robot assistants for perimetry: Patient experience and performance. Allison M. McKendrick1, A. Zeman1, I. Aden1, D. Aktepe1, D. Bhagat1, K. Do1, H. D. Nguyen1, A. Turpin2. 1Optometry & Vision Sciences, University of Melbourne, Parkville, Victoria, Australia; 2Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia *CR

6028 — 11:15 A New Method to Detect Visual Field Progression based on Spatial Pattern Analysis. Dian Li1, L. R. Pasquale2, L. Q. Shen2, M. V. Boland3, S. R. Wellik4, C. De Moraes5, J. S. Myers6, N. Baniasadi1, H. Wang1, 7, P. J. Bex8, T. Elze1, M. Wang1. 1Schepens Eye Research Institute, Harvard Medical School, Boston, MA; 2Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 3Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 4Bascom Palmer Eye Institute, University of Miami, Miami, FL; 5Edward S. Harkness Eye Institute, Columbia University, New York, NY; 6Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA; 7Institute for Psychology and Behavior, Jilin University of Finance and Economics, Changchun, Jilin, China; 8Department of Psychology, Northeastern University, Boston, MA *CR

6029 — 11:30 Visual Field Testing on a Personal Smartphone. Moshe Eizenman1, 2, R. B. Shi3, T. L. Fee4, Y. J. Mahsood1, Y. M. Buys1, G. Trope1. 1Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 2Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada; 3Division of Engineering Science, University of Toronto, Toronto, Ontario, Canada; 4Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada

6030 — 11:45 Effect of fundus tracking on perimetric test retest-variability. Susan R. Bryan1, G. Montesano1, 2, L. M. Rossetti2, P. Fogagnolo2, F. Oddone3, A. M. McKendrick4, A. Turpin5, P. Lanzetta6, A. Perdicchi7, C. A. Johnson8, D. F. Garway-Heath9, 10, D. P. Crabb1. 1Optometry and Visual Sciences, City, University of London, London, United Kingdom; 2Eye Clinic, University of Milan, Milan, Italy; 3Glaucoma Unit, IRCCS GB Bietti Eye Foundation, Rome, Italy; 4Optometry & Vision Sciences, University of Melbourne, Melbourne, Victoria, Australia; 5Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia; 6Department of Ophthalmology, University of Udine, Udine, Italy; 7Azienda ospedaliera Sant’Andrea, Rome, Italy; 8Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA; 9Institute of Ophthalmology, University College London, London, United Kingdom; 10NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom *CR

6031 — 12:00 Clinical evaluation of a new perimetric testing algorithm, SITA Faster. Vincent Michael Patella1, B. Bengtsson2, G. C. Lee1, L. X. Chong6, J. G. Flanagan6, A. Iwase5, C. K. Leung3, J. Ring2, A. Tuulonen4, T. Callan1, 6, A. Heijl2. 1Carl Zeiss Meditec, Inc, Dublin, CA; 2Department of Ophthalmology, Skane University Hospital Malmö, Lund University, Malmö, Sweden; 3Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China; 4Tays Eye Centre, University of Tampere, Tampere, Finland; 5Tajimi Iwase Eye Clinic, Tajimi, Japan; 6School of Optometry, University of California, Berkeley, CA *CR

6032 — 12:15 Performance of a modified 24-2 test pattern using SITA Faster. Gary C. Lee1, M. Monhart2, T. Callan1, B. Cunningham1, S. Yu1, M. K. Durbin1, B. Bengtsson3, A. Iwase4, J. G. Flanagan5, A. Heijl3. 1Carl Zeiss Meditec, Inc, Dublin, CA; 2Carl Zeiss AG, Feldbach, Switzerland; 3Ophthalmology, Lund University, Malmo, Sweden; 4Ophthalmology, Tajimi Iwase Eye Clinic, Tajimi, Japan; 5School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA *CR

6033 — 12:30 A comparison of relative diagnostic precision between the Compass fundus perimeter and the Humphrey Field Analyzer. Luca M. Rossetti1, G. Montesano1, 2, S. R. Bryan2, P. Fogagnolo1, F. Oddone3, A. M. McKendrick4, A. Turpin5, P. Lanzetta6, A. Perdicchi7, C. A. Johnson8, D. F. Garway-Heath9, 10, D. P. Crabb2. 1Eye Clinic, University of Milan, Milan, Italy; 2Optometry and Visual Sciences, City, University of London, London, United Kingdom; 3Glaucoma unit, IRCCS GB Bietti Eye Foundation, Rome, Italy; 4Optometry & Vision Sciences, University of Melbourne, Melbourne, Victoria, Australia; 5Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia; 6Department of Ophthalmology, University of Udine, Udine, Italy; 7Azienda ospedaliera Sant’Andrea, Rome, Italy; 8Ophthal & Visual Sci, University of Iowa, Iowa City, IA; 9Institute of Ophthalmology, University College London, London, United Kingdom; 10NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom *CR

Ballrooms BC


537 Pharmacological Interventions and Cellular Mechanisms

Moderators: Claire H. Mitchell and Abbot F. Clark

6034 — 11:00 Linking stressed astrocytes to activated microglia through purinergic signaling. Claire H. Mitchell, K. Campagno, F. Albalawi, W. Lu. University of Pennsylvania, Philadelphia, PA

6035 — 11:15 Inhibition of chronic endoplasmic reticulum stress rescues myocilin-associated glaucoma via stimulation of autophagic flux in the TM. Ramesh Kasetti, p. maddineni, P. Patel, G. Zode. pharmacology and neuroscience, North Texas Eye Research Institute, Fort Worth, TX

6036 — 11:30 The effects of Vitamin B3 on fibroblast mitochondrial function in glaucoma patients. Zaman Durani2, D. Gkotsi2, D. Chau3, D. F. Garway-Heath1, 2. 1NIHR Biomedical Research Centre at Moorfields Eye Hospital, London, United Kingdom; 2UCL Institute of Ophthalmology, London, United Kingdom; 3Institute of Neurology, London, United Kingdom

6037 — 11:45 Glucocorticoid-Induced Ocular Hypertension in Mice Requires Glucocorticoid Receptor Transactivation Activity. Abbot F. Clark, J. Millar, G. Patel. North Texas Eye Research Institute, University of North Texas HSC, Fort Worth, TX *CR


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6038 — 12:00 RHO-kinase-mediated regulation of myofibroblast differentiation in scleral fibroblasts during experimental glaucoma. Ian F. Pitha, E. Oglesby, E. Cone-Kimball, J. Schaub, M. Pease, H. A. Quigley. Ophthalmology, Hopkins University, Baltimore, MD

6039 — 12:15 Distal outflow resistance can be regulated pharmacologically. Fiona McDonnell1, W. Dismuke1, D. R. Overby2, W. Stamer1. 1Ophthalmology, Duke University, Durham, NC; 2Bioengineering, Imperial College London, London, United Kingdom

6040 — 12:30 Δ9-THC and CBD differentially regulate intraocular pressure. Alex Straiker, S. Miller. Indiana University, Bloomington, IN



– 12:45 pm



Thursday, May 03, 2018 11:00 AM-12:45 PMGenetics Group

538 Potpourri in genetic eye disease

Moderator: Periasamy Sundaresan

6041 — A0075 BMP4 loss of function mutation is a cause of autosomal dominant Stickler syndrome with associated renal dysplasia in one family. Thomas R. Nixon1, 2, A. Richards3, 4, L. Towns3, R. Sandford4, 5, M. Snead1, 3. 1Ophthalmology, Cambridge University Hospital NHS Foundation Trust, Cambridge, England, United Kingdom; 2Faculty of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom; 3Department of Pathology, University of Cambridge, Cambridge, United Kingdom; 4Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; 5Medical Genetics, University of Cambridge, Cambridge, United Kingdom

6042 — A0076 Clinical and Genetic Characterization of Canine Vitreous Degeneration. Maria Kaukonen1, 2, H. Lohi1, 2. 11Department of Veterinary Biosciences and Research Programs Unit, University of Helsinki, Helsinki, Finland; 2Folkhälsan Institute of Genetics, Helsinki, Finland *CR

6043 — A0077 Heimler syndrome with macular dystrophy caused by novel PEX6 gene variants. Benjamin Bakall1, 2, J. Singer2, 3, J. L. Andorf4, E. M. Stone4, M. Champion2, 5. 1Ophthalmology, University of Arizona College of Medicine Phoenix, Phoenix, AZ; 2Associated Retina Consultants, Phoenix, AZ; 3Iowa Retina Consultants, West Des Moines, IA; 4Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA; 5Department of Ophthalmology, The University of Kansas, Kansas City, KS

6044 — A0078 Copy number variations in CNGB3-linked autosomal recessive achromatopsia. Susanne Kohl1, A. K. Mayer1, c. Van Cauwenbergh2, C. Rother1, B. Baumann1, P. Reuter1, E. De Baere2, B. Wissinger1. 1Centre for Ophthalmology, Inst for Ophthalmic Rsrch Tuebingen, Tuebingen, Germany; 2Ghent University and University Hospital, Ghent, Belgium

6045 — A0079 Novel PAX6 heterozygous mutations found in two Chinese families with congenital aniridia. Bo Gong, J. Li. Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China

6046 — A0080 Efficient High-Throughput Targeted Exome Sequencing Kit for Differential Diagnosis of Congenital Special Forms of Strabismus. Yi Liang1, H. Jia1, Y. Liang2, H. Wang1, Y. Jiao1. 1Beijing Tongren Hospital, Beijing, China; 2University of Maryland, Baltimore, MD

6047 — A0081 Molecular characterization of congenital eye malformations. Teresa M. Neuhann1, L. Neuhann1, A. Laner1, A. Benet-Pages1, T. Neuhann2, E. Holinski-Feder1. 1Medizinisch genetisches Zentrum, Munich, Germany; 2MVZ Prof. Neuhann, Munich, Germany

6048 — A0082 Comprehensive Genetic Testing Identifies Rare Pathogenic Variants for Anterior Segment Dysgenesis. Dayna Morel2, S. Thanikachalam1, E. Hodapp3, T. C. Chang3, F. Cengiz1, G. Bademci1, W. Scott1, A. Grajewski3, M. Tekin1, 2. 1John P.Husmann Institute for Human Genomics, University of Miami, Miami, FL; 2Department of Human Genetics, University of Miami, Miami, FL; 3Bascom Palmer Eye Institute, University of Miami, Miami, FL *CR

6049 — A0083 Contribution of HLA-A and HLA-B genes to genetic predisposition in ocular Behçet’s disease. Akira Meguro, T. Yamane, M. Takeuchi, N. Mizuki. Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, KANAGAWA, Japan

6050 — A0084 Comprehensive genetic analysis of the mir-183/96/182 cluster illuminates a cooperative function for support of hair cells but not retina. Joseph Fogerty1, L. T. Cianciolo1, 2, B. P. Tooke1, 3, B. D. Perkins1. 1Ophthalmic Research, Cleveland Clinic, Cleveland, OH; 2John Carroll University, University Heights, OH; 3Case Western Reserve University, Cleveland, OH

6051 — A0085 Key pathways and genes influenced by a drug, NK-4, in human neurons. Shihui Liu1, T. Matsuo1, M. Miyaji2, O. Hosoya2. 1Ophthalmology, Okayama University, Okayama, Japan; 2Medical Neurobiology, Okayama University, Okayama, Japan

6052 — A0086 A new mitochondrial disease: MICHRED “‘Mitochondrial disorder with Intracranial Calcification, REnal disease, REtinopathy, and Deafness.”. Edward H. Wood1, A. Kreymerman2, S. Randhawa1. 1Vitreoretinal Surgery, Associated Retinal Consultants, Ann Arbor, MI; 2School of Medicine, Stanford University, Stanford, CA

6053 — A0087 Ocular Vascular Manifestations of Fabry Disease in α-galactosidase A-deficient Rats. Iris S. Kassem1, 2, J. J. Miller3, C. Reid1, N. M. Dahms3. 1Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI; 3Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI

6054 — A0088 THBS1 polymorphism associated with increased risk of pterygium and altered thrombospondin 1 expression. Vinny Keshav, L. Simon, C. Baharozian, R. Regan, S. Masli, H. J. Lee. Ophthalmology, Boston Medical Center, Boston, MA

6055 — A0089 Gene expression pattern difference between pterygium fibroblasts and other types of fibroblasts. Judith Zavala, V. Trevino, J. E. Valdez. Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico

6056 — A0090 Clinical description and genetic molecular analysis in three non-related Mexican families with Wolfram syndrome: identification of two novel WFS1 mutations. Rodrigo Matsui1, 2, O. Chacon-Camacho2, J. C. Zenteno2, E. Esparza-García3, J. I. Bianchi1, U. de Dios Cuadras1. 1Retina, Inst de Oftalmologia Fundacion CONVAL, Cuernavaca, Mexico; 2Genetics, Instituto de Oftalmologia CONVAL, Mexico City, Mexico; 3Genetics, Centro Médico Nacional Siglo XXI, Mexico City, Mexico

6057 — A0091 LI profiling, a novel algorithm to investigate genotype-phenotype relationships for large dataset. Jing Yu1, C. Murphy2, N. PONTIKOS3. 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; 2University of Warwick, Warwick, United Kingdom; 3University College London, London, United Kingdom


Thursday, May 03, 2018 11:00 AM-12:45 PMRetinal Cell Biology / Low Vision / Visual Psychophysics/Physiological Optics

539 Retinal diseases and aging: preclinical studies

Moderator: Kenkichi Baba

6058 — A0187 Molecular analysis of the p.D477G in RPE65 as a cause of Choroideremia. Lance P. Doucette, a. radziwon, I. M. MacDonald. Ophthalmology & Visual Sciences, University of Alberta, Edmonton, Alberta, Canada

6059 — A0188 Scleral pits are a sign of disease severity in choroideremia. Christy Cunningham1, 2, H. Daggett2, 1, E. Stone1, 2, I. Han1, 2. 1Ophthalmology, University of Iowa, Iowa City, IA; 2Stephen A. Wynn Institute for Vision Research, Iowa City, IA

6060 — A0189 Retinal degeneration in choroideremia follows an exponential decay function. James W. Aylward1, K. Xue1, 2, M. I. Patrício1, 2, J. K. Jolly1, 2, J. C. Wood1, J. Brett1, K. Jasani1, R. E. MacLaren1, 2. 1Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; 2Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom *CR


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6061 — A0190 Lipidosis in aging monkey retinal epithelium. Peter Gouras1, T. Nagasaki1, M. Neuringer2, L. Ivert3. 1Ophthalmology, Columbia University, New York, NY; 2Oregon National Primate Research Center, Beaverton, OR; 3Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

6062 — A0191 Sodium iodate-induced retinal degeneration in small animal models for Age-related Macular degeneration. Céline Koster1, A. ten Asbroek1, J. ten Brink1, R. O. Schlingemann1, J. C. van Meurs3, F. D. Verbraak2, 1, T. Smit2, 1, C. Boon1, 4, A. A. Bergen1, 5. 1AMC, Amsterdam, Netherlands; 2VUmc, Amsterdam, Netherlands; 3Rotterdam Eye Hospital, Rotterdam, Netherlands; 4LUMC, Leiden, Netherlands; 5NIN-KNAW, Amsterdam, Netherlands

6063 — A0192 Describing biomarkers for Alzheimer’s disease: Localization of amyloid-β in the retina. Qinyuan (Alis) Xu1, S. Lee2, V. Hirsch-Reinshagen3, I. Mackenzie3, R. Hsiung4, S. Cao5, K. Jiang5, M. Sarunic2, M. Beg2, J. Z. Cui5, J. A. Matsubara5. 1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; 2School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada; 3Pathology, University of British Columbia, Vancouver, British Columbia, Canada; 4Neurology, University of British Columbia, Vancouver, British Columbia, Canada; 5Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

6064 — A0193 Long-term outer retinal damage in rats exposed to neonatal hypoxia-ischemia. Suna Jung1, 2, Z. Khoja1, S. Chemtob3, 4, P. Lachapelle2, P. Wintermark1. 1Dept. Pediatrics, Div. Newborn Medicine, Research Institute of the McGill University Health Centre/Montreal Children’s Hospital, McGill University, Montreal, Quebec, Canada; 2Depts. Ophthalmology and Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children’s Hospital, McGill University, Montreal, Quebec, Canada; 3Depts. Pediatrics, Pharmacology, and Ophthalmology, CHU Ste-Justine, Université de Montréal, Montreal, Quebec, Canada; 4Pharmacology, CHU Ste-Justine, Montreal, Quebec, Canada

6065 — A0194 In vivo imaging of curcumin labeled amyloid beta deposits in retina using fluorescence scanning laser ophthalmoscopy in an Alzheimer mouse model. Ahmad M. Sidiqi1, D. Wahl2, S. Lee2, S. Cao1, J. Z. Cui1, E. To1, M. Beg2, M. Sarunic2, J. A. Matsubara1. 1Opthalmology and Visual Sciences, University of British Columbia, Markham, Ontario, Canada; 2Simon Fraser University, Burnaby, British Columbia, Canada

6066 — A0195 Age related visual deficits in tie2-TNF mice mediated by endoplasmic reticulum stress. Peter G. Nagy2, R. Rajesh Lenin2, J. Gentry1, R. Gangaraju1. 1Ophthalmology, Hamilton Eye Institute, Memphis, TN; 2Ophthalmology, University of Tennessee Health Science Center, Memphis, TN *CR

6067 — A0196 Evaluation of hydrogen sulfide (H2S) effects on visual functions and pyroptosis in a mouse model of hyperhomocysteinemia. Mahavir Singh2, A. George1, R. P. Homme3, A. Majumder4, S. Tyagi5. 1Physiology, University of Louisville School of Medicine, Louisville, KY; 2Eye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, KY; 3Physiology, University of Louisville School of Medicine, Louisville, KY; 4Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY; 5Physiology, University of Louisville School of Medicine, Louisville, KY

6068 — A0197 Proteomic changes in retina after transient middle cerebral artery occlusion. Saema Ansar1, L. J. Cehofski2, F. W. Blixt1, K. Haanes3, V. Fedulov3, B. Honoré4, L. Edvinsson1, 3, K. Warfvinge3, 1. 1Department of Clinical Sciences, Lund University, Lund, Sweden; 2Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark; 3Department of Clinical Experimental Research, Copenhagen University Hospital, Glostrup, Denmark; 4Department of Biomedicine, Aarhus University, Aarhus, Denmark

6069 — A0198 Expression and activation of SAPK/JNK in the ONH in a rat model of ocular hypertension. Teresa Mammone1, 2, G. Chidlow1, 2, R. J. Casson1, 2, J. P. Wood1, 2. 1Ophthalmology, SA Health, Woodville South, South Australia, Australia; 2Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia

6070 — A0199 Age related changes in visual and retinal function in Alagille syndrome. Laura Bagdonaite-Bejarano, R. M. Hansen, A. Moskowitz, W. Tan, A. B. Fulton. Boston Children’s Hospital/Harvard Medical School, Boston, MA

6071 — A0200 Ceramide-induced Mitochondrial Damage in Diabetic Retinopathy. Yan Levitsky1, 4, S. S. Hammer2, T. Lydic5, 2, A. Muchnik3, A. Saripalli3, P. Kirschner2, 56, D. Pegouske1, D. Proshlyakov3, J. V. Busik2. 1Physiology/Chemistry, Michigan State University, East Lansing, MI; 2Physiology, Michigan State University, East Lansing, MI; 3Chemistry, Michigan State University, East Lansing, MI; 4DO/PhD - Physician Scientist Training Program, Michigan State University, East Lansing, MI; 5Molecular Metabolism and Disease - Mass Spectrometry Core, Michigan State University, East Lansing, MI; 6Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

6072 — A0201 Comparative study of VEGF inhibitors in Oxygen Induced Retinopathy (OIR) mouse model: Vascular, non-vascular and functional implications. Magali Evelin E. Ridano1, M. Paz1, P. V. Subirada1, J. D. Luna Pinto2, D. O. Croci Russo3, P. F. Barcelona1, M. Vaglienti1, G. A. Rabinovich3, M. C. Sanchez1. 1Department of Clinical Biochemistry, CIBICI-CONICET, Faculty of Chemical Sciences, National University of Cordoba, Cordoba, Argentina; 2VER Foundation, Private Eye Center Romagosa, Cordoba, Argentina; 3IByME-CONICET, Faculty of Medicine, University of Buenos Aires, Capital Federal, Buenos Aires, Argentina

6073 — A0202 Retinal degeneration in a mouse model of neuronal ceroid lipofuscinosis type 1 (CLN1). Yevgeniya Atiskova1, T. Danyukova3, E. Becker1, S. Bartsch1, C. Hagel2, S. Storch3, U. Bartsch1. 1Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3Childrens Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

6074 — A0203 Implication of various oxidative stress pathways in the aging phenotype of Prpf31-mutant mice. Abdallah Hamieh1, N. Hadjout1, G. Millet-puel2, T. D. Leveillard2, E. F. Nandrot1. 1Therapeutics Department, Institut de la Vision, Faculté des Sciences Sorbonne Université, INSERM U968, CNRS UMR 7210, Paris, France; 2Genetics Department, Institut de la Vision, Faculté des Sciences Sorbonne Université, INSERM U968, CNRS UMR 7210, Paris, France

6075 — A0204 Risk of recurrent and chronic disease in a large cohort of acute central serous chorioretinopathy with long-term follow-up. Danial Mohabati1, 2, T. O. Missotten5, E. de Jong3, C. Boon1, 4, S. Yzer5. 1Leiden University Medical Center, Leiden, Netherlands; 2Rotterdam Ophthalmic Institute, Rotterdam, Netherlands; 3Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands; 4Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; 5Rotterdam Eye Hospital, Rotterdam, Netherlands

6076 — A0205 Novel mutation in LRRTM4 is associated with dominantly inherited macular dystrophy with reduced ON-bipolar cell response. Akiko Suga1, Y. Kawamura1, K. Yoshitake1, 3, K. Tsunoda1, A. Murakami2, T. Iwata1. 1National Institute of Sensory Organs, National Hospital Organization, Tokyo, Japan; 2Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; 3Graduate school of Agricultural and Life Science, University of Tokyo, Tokyo, Japan



– 12:45 pm


6077 — A0206 Structural, functional and molecular alterations in the retina of a mouse model of Alzheimer’s disease. Antonio F. Ambrosio1, 2, C. Neves1, 2, S. Chiquita1, 2, R. Carecho1, 2, F. Baptista1, 2, E. J. Campos1, 2, P. Moreira3, 2. 1Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Portugal, Coimbra, Portugal; 2CNC.IBILI Consortium, University of Coimbra, Portugal, Coimbra, Portugal; 3 Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Coimbra, Portugal

6078 — A0207 Intravitreal Enzyme replacement therapy attenuates retinal disease progression in a canine model of neuronal ceroid lipofuscinosis type 2 (CLN2). John Sinclair1, R. Whiting2, G. Robinson2, K. Bibi2, A. Nguyen1, A. Cherukuri1, J. Henshaw1, G. de Hart1, C. Sundeep1, C. O’Neil1, M. Katz2. 1Pharmacology / Toxicology, BioMarin Pharmaceutical Inc., Novato, CA; 2Research, University of Missouri, Columbia, MO

6079 — A0208 Retinal iron accumulation and degeneration in mice with high blood iron levels. Bailey Baumann, Y. Song, J. L. Dunaief. F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

6080 — A0209 Treatment of age related macular degeneration using nanosecond laser therapy: Safety profile studies in humans and mice. Kirstan A. Vessey1, T. Ho1, A. I. Jobling1, S. A. Mills1, M. Tran1, A. Brandli1, J. Lam1, R. H. Guymer2, E. L. Fletcher1. 1Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia; 2Department of Surgery (Ophthalmology), Center for Eye Research Australia, Melbourne, Victoria, Australia f



540 Surgery and Wound Healing III

Moderator: Christopher K. Leung

6081 — C0200 Risk related morphometric considerations after prophylactic laser iridotomy (LPI) in primary angle closure suspect (PACS). Alex Casanova1, 2, A. Galli2, E. Gibin1, 2, F. Borner2, N. Righetti2, A. Consigli2, M. Vignanelli2. 1Ophthalmology, KSA, Aarau, Switzerland; 2Ophthalmology, EOC, Lugano, Switzerland


6082 — C0201 Five-year comparative observation of corneal endothelium and angle structure in laser iridotomy-treated and –untreated primary angle closure or its suspect eyes. Koichi Mishima1, 2, N. Mataki1, M. Yonahara5, S. Otani5, H. Sakai3, A. Tomidokoro4, M. Aihara2, K. Miyata5, A. Iwase6, M. Araie1. 1ophthalmology, Kanto central Hospital, Setagaya-ku, Japan; 2University of Tokyo, Graduate school of medicine, Tokyo, Japan; 3Department of Ophthalmology, University of the Ryukyus, faculty of medicine, Nakagami-gun, Japan; 4Tomidokoro Eye Clinic, Nakano-ku, Japan; 5Miyata Eye Hospital, Miyakonojo-city, Japan; 6Tajimi Iwase Eye Clinic, Tajimi-city, Japan *CR

6083 — C0202&#tab; Quantitative analysis of anterior and posterior ocular biometry after pharmacological mydriasis in angle closure diseases. Yi Sun, S. Chen, X. Zhang. Zhongshan Ophthalmic Center, Guangzhou, China f

6084 — C0203 Side Effects After Laser Peripheral Iridotomy Comparing Lateral Vs Superior Locations in Puerto Rican Population. Rosa A. Lozada Sierra. Ophthalmology, Univeridad de Puerto Rico, Recinto de Ciencias Medicas, Caguas, Puerto Rico

6085 — C0204 Electron-beam irradiated corneal (haloTM) versus scleral patch graft erosion rates in glaucoma drainage device surgery. Ross Passo1, Z. Hoskins1, K. D. Tran2, C. Patzer2, S. Tehrani1. 1Casey Eye Institute, Oregon Health & Science University, Portland, OR; 2Research and Development, Lions VisionGift, Portland, OR *CR

6086 — C0205 Change in intraocular pressure following selective laser trabeculoplasty among Hispanics in South Texas. Jobeth Nozicka1, C. Villaflor1, R. Trevino1, C. Majcher1, A. Schnegg1, U. Bui1, W. E. Sponsel1, 2. 1Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX; 2Biomedical Engineering, University of Texas San Antonio, San Antonio, TX

6087 — C0206&#tab; Long Term Efficacy of Selective Laser Trabeculoplasty Performed by Residents in a Large Veteran Population. Junping Li1, 2, C. Johnson2, C. Kirk2. 1Ophthalmology, Hines VA Medical Center, Hines, IL; 2Ophthalmology, Loyola University of Chicago, Maywood, IL

6088 — C0207 Long Term Effect and Predictive Factors of Success for Selective Laser Trabeculoplasty (SLT). Christopher Johnson1, 2, J. Li2, 1, C. Kirk2, 1. 1Ophthalmology, Loyola University Medical Center, Lombard, IL; 2Ophthalmology, Edward Hines Jr Veteran’s Association, Hines, IL

6089 — C0208 Comparison of Outcomes of Micropulse Laser Trabeculoplasty versus Selective Laser Trabeculoplasty. Catherine Q. Sun, Y. Ou. University of California San Francisco, San Francisco, CA

6090 — C0209 Analysis of the Relative Efficacy of Micropulse Laser Trabeculoplasty and Selective Laser Trabeculoplasty. Briana C. Gapsis1, M. Bickford2, R. A. Sharpe1, S. Das1, L. Kammerdeiner1, M. J. Nutaitis1. 1Ophthalmology, Medical University of South Carolina, Charleston, SC; 2Medical University of South Carolina, Charleston, SC

6091 — C0210 Primary Selective Laser Trabeculoplasty for Primary Open Angle Glaucoma & Ocular Hypertension: Early clinical outcomes from a prospective, multi-centre randomised controlled UK trial. Anurag Garg1, V. Vickerstaff2, N. Nathwani1, E. Konstantakopoulou1, E. Dowse1, G. Gazzard1. 1Glaucoma, Moorfields Eye Hospital, London, United Kingdom; 2University College London, London, United Kingdom *CR, f

6092 — C0211 Long-term result of Intraocular Pressure Reduction Efficacy of Pattern Laser Trabeculoplasty in Refractory Glaucoma Patients. Seung Joo Ha, S. Lee, Y. Kim. Ophthalmology, Soonchunhyang University, Seoul, Korea (the Republic of)

6093 — C0212 Normalization of Visual Evoked Potential with Treatment of Selective Trabeculoplasty Laser. Yianni Yiannakou, L. H. Nguyen, P. Namkoong, K. Narain. Ophthalmology, South Bay Retina, Sunnyvale, CA

6094 — C0213 Towards feedback controlled selective laser trabeculoplasty (SLT). Katharina Bliedtner, D. Meier, E. Seifert, R. Brinkmann. Medical Laser Center Luebeck, Lübeck, Germany

6095 — C0214 The consensual ophthalmotonic reaction following selective laser trabeculoplasty. Frank Mei1, H. Tokko1, J. Zeiter2, N. Nassiri2, C. Kim2, R. Swendris2, M. S. Juzych2, A. Goyal2, E. In’t Veld2, A. Mas-Ramirez2, B. Hughes2. 1Wayne State University School of Medicine, Detroit, MI; 2Kresge Eye Institute, Detroit, MI

6096 — C0215 Evaluating the efficacy of selective laser trabeculoplasty in patients who underwent prior intraocular pressure reducing procedures. Clayton Kirk1, J. Li2, C. Johnson1, 2. 1Ophthalmology, Loyola University Chicago, River Forest, IL; 2Ophthalmology, Edward Hines Jr. Veterans Administration Hospital, Hines, IL

6097 — C0216 MLT vs SLT in the Hispanic and African American Population for Treatment of Open-Angle Glaucoma. Robert G. Dionisio1, O. L. German2, T. Patrianakos2, M. Giovingo2. 1School of Medicine, Chicago Medical School, Chicago, IL; 2Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL

6098 — C0217 A randomized controlled trial(RCT) comparing the efficacy and safety of pattern laser trabeculoplasty(PLT) and selective laser trabeculoplasty(SLT). Oi Man Mandy Wong1, 2, I. Lai1, 2, P. Chan1, 2, C. Chan1, 2, C. K. Leung1. 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2Hong Kong Eye Hospital, Hong Kong, Hong Kong *CR, f

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6107 — C0226 Success Rate of Micropulse Transscleral Cyclophotocoagulation in Complex Glaucoma Based on Variable Treatment Duration. Facundo G. Sanchez1, F. Lerner3, J. Sampaolesi3, R. Noecker2, N. Becerra3, G. Iribarren4, T. M. Grippo2, 1. 1Grippo Glaucoma Center, Buenos Aires, CABA, Argentina; 2Yale University, New Haven, CT; 3Glaucoma Center, Buenos Aires, Argentina; 4Hospital Alemán, Buenos Aires, Argentina

6108 — C0227 Short Term Outcomes of Micropulse Transscleral Cyclophotocoagulation in an Urban Public Hospital. Jun Hui Lee1, 2, B. Amoozgar2, S. C. Lin2, S. Padmanabhan2. 1Yale School of Medicine, NEW HAVEN, CT; 2Ophthalmology, University of California, San Francisco, San Francisco, CA *CR

6109 — C0228 Treatment Pathways of Primary Open Angle Glaucoma prior to Laser Surgery: Real World Evidence from UK Ophthalmology Clinics. Yongsoo Kim1, J. Banhazi1, A. Durus1, L. Rodriguez Torres1, A. Gondos2, D. Viriato1, V. Bezlyak1, N. Boxall2, T. Wintermantel2, A. Sagkriotis1, D. Hubatsch3. 1Novartis Pharma AG, Basel, Baselstadt, Switzerland; 2IQVIA Real World Insights, Frankfurt, Germany; 3Novartis Pharmaceuticals Corporation, Fort Worth, TX *CR



541 Neuroprotection

Moderators: Kimberly K. Gokoffski and Miriam Kolko

6110 — C0229 Induced pluripotent stem cells promote retinal ganglion cell survival after transplant. Suqian Wu1, 2, K. Chang2, M. Nahmou2, J. L. Goldberg2. 1Department of Ophthalmology & Visual Science, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai, Shanghai, China; 2Department of Ophthalmology, Byers Eye Institute at Stanford University, Palo Alto, CA

6111 — C0230 Rescue of retinal ganglion cells by human umbilical cord mesenchymal stem cells in a microbead induced ocular hypertension rat model. Shangli Ji1, Z. Li2, H. Xu3, J. Chen1, 3, S. Tang1, 3. 1ophthalmology, Aier School of ophthalmology, Changsha, China; 2Central South University, Changsha, China; 3Aier Eye Institute, Changsha, United Kingdom

6112 — C0231 Development of injectable antioxidant drug carriers for glaucoma therapy. Li-Jyuan Luo1, J. Lai2. 1Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan; 2Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan

6113 — C0232 Sustained release of Tafluprost with a newly developed drug delivery system protects retinal ganglion cells in rats after optic nerve transection. Yurika Nakagawa, K. Sato, K. Omodaka, T. Nakazawa. Tohoku university, Sendai, Japan *CR

6114 — C0233 Therapeutic potential of Valproic acid in End Stage Glaucoma. Viney Gupta, K. Mahalingam, R. SIHOTA, T. Velpandian, S. Gupta, A. Chaurasia. Ophthalmology, All India Institute of Medical Sciences, Delhi, Delhi, India f

6115 — C0234 Citicoline ameliorates the effect of elevated intraocular pressure on functional connectivity in the visual pathway. Kevin C. Chan1, 2, Y. van der Merwe3, 4, M. C. Murphy3, 5, L. C. Ho3, X. Yang3, Y. Yu6, Y. Chau6, C. K. Leung7, 8, G. Wollstein1, J. S. Schuman1. 1NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, New York University, New York, NY; 2Department of Radiology, NYU School of Medicine, New York University, New York, NY; 3Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 4Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; 5Department of Radiology, Mayo Clinic, Rochester, MN; 6Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong, Hong Kong; 7Hong Kong Eye Hospital, University Eye Center, Hong Kong, Hong Kong; 8Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong*CR

6116 — C0235 Neuro-protective effect of resveratrol on ischemia/reperfusion-Induced Retinal Injury in mice. Mingming Zhu, B. N. Choy, J. S. Lai. Ophthalmology, The University of Hong Kong, Hong Kong, Hong Kong

6117 — C0236 Topical Curcumin Nanocarriers are Neuroprotective in Rodent Retinal Injury Models. Ben Davis1, L. Guo1, M. Pahlitzsch1, S. Balendra1, P. Shah1, N. Ravindran1, G. Malaguarnera1, C. Sisa1, E. Shamsher1, H. Hamze1, A. Noor1, A. Sornsute2, S. Somavarapu2, M. Cordeiro1. 1Institute of Ophthalmology, University College London, London, United Kingdom; 2School of Pharmacy, University College London, London, United Kingdom *CR

6118 — C0237 Anthocyanin oligomers counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. Kui Dong Kang1, H. Hwang1, S. Kim2. 1Department of Ophthalmology, Incheon St. Mary’s Hospital, Incheon, Korea (the Republic of); 2Department of Ophthalmology, SahmYook Medical Center, Seoul, Korea (the Republic of)

6119 — C0238 Cyanin chloride inhibits hyperbaric pressure-induced glutamate-aspartate transporter decrease in mouse retina Müller cells. Min Ke, X. CHEN, F. Han. Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubai, China

6099 — C0218 Efficacy of Attending versus Resident performed Selective Laser Trabeculoplasty. Bingjie Ling1, Y. Tripodis2, S. Rowe1. 1Department of Ophthalmology, Boston University Medical Center, Boston, MA; 2Department of Biostatistics, Boston University School of Public Health, Boston, MA

6100 — C0219 Intraocular Pressure Reduction After Ultrasound Cyclo Plasty for Glaucoma: Relationship With Biometric Parameters and Intraocular Inflammation. Stefano Sebastiani1, G. Giannaccare1, M. Pellegrini1, L. Urbini2, L. Carmassi2, E. Bulone2, F. Bergamini2, E. C. Campos1. 1S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy; 2Department of Ophthalmology, Scientific Insitute Capitanio Hospital - Istituto Auxologico Italiano, Milan, Italy

6101 — C0220 Micropulse Transscleral Cyclophotocoagulation or MP-TCP VS Endoscopic Cyclophotocoagulation-Plus or ECP-Plus. Behzad Amoozgar, M. Feinstein, J. Lee, K. Liu, T. Porco, J. M. Stewart, Y. Han. Ophthalmology, UCSF, San Francisco, CA

6102 — C0221 Comparing endoscopic cyclophotocoagulation-plus (ECP-Plus) with anterior ECP for the treatment of refractory glaucoma. Jessica M. Kang1, M. Feinstein1, J. Lee1, B. Amoozgar1, K. Liu1, J. M. Stewart1, G. Lazcano-Gomez2, T. Porco1, Y. Han1. 1Ophthalmology, UCSF, San Francisco, CA; 2Asociación para Evitar la Ceguera en México, Mexico City, Mexico

6103 — C0222 Evaluating the Long-Term Effects of Micropulse Cyclophotocoagulation on Glaucoma Patients. Soshian Sarrafpour1, S. Ayoub2, N. M. Radcliffe3. 1Ophthalmology, New York University, New York, NY; 2Medical School, New York University, New York, NY; 3Ophthalmology, Weill Cornell Medical Center., New York, NY *CR

6104 — C0223 Long-Term Outcomes of Micropulse Cyclophotocoagulation in Eyes With and Without Prior Tube Shunt Surgery. Samantha Ayoub2, S. Sarrafpour2, N. M. Radcliffe2, 1. 1New York Eye Surgery Center, New York City, NY; 2Department of Ophthalmology, New York University, New York City, NY *CR

6105 — C0224 Refractory glaucoma treated with endolaser cyclophotocoagulation during pars plana vitrectomy. Nana Takahashi, Y. Yokoyama, H. Kunikata, K. M. NIshiguchi, F. Nitta, T. Takeshita, T. Nakazawa. Ophthalmology, Tohoku University, Sendai, Miyagi, Japan *CR

6106 — C0225 Trans-scleral Cyclophotocoagulation: A Tale of Two Probes. Leonard Seibold, C. E. Capitena Young, D. A. Ammar, M. Y. Kahook. Ophthalmology, University of Colorado, Denver, CO



– 12:45 pm


6120 — C0239 Hesperidin has an anti-inflammatory effect after NMDA-induced retinal injury in mice. Taimu Sato, K. Sato, T. Nakazawa. Tohoku University, Sendai, Miyagi, Japan *CR

6121 — C0240 Caveolin-1 Protects retinal ganglion cells(RGCs) in a Glaucoma Model. Wenjie Hu1, L. Zhang2, Z. Tang1. 1State Key Laboratory of Ophthalmology, ZhongShan Ophthalimic Center Sun Yat-Sen University, Guangzhou, Guangdong, China; 2Second People’s Hospital of Yunnan Province, Kunming, China

6122 — C0241 Mechanistic insights into the PTPN11 actions in the retinal ganglion cells and effects of its loss under glaucoma conditions. mojdeh abbasi1, V. Gupta1, N. Chitranshi1, S. L. Graham1, 2. 1Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia; 2Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia

6123 — C0242 Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Huiping Yuan, D. Lei, Z. Shao, X. Zhou. Department of Ophthalmology, Harbin Medical University, Harbin, Heilongjiang, China

6124 — C0243 Bexarotene suppresses the retinal expression of ER stress marker proteins p-PERK and GADD153 in experimental model of glaucoma. yogita dheer, N. Chitranshi, S. L. Graham, V. Gupta. Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia

6125 — C0244 Evaluation of the Potential of AR-13324 and AR-13503 to Induce Phospholipidosis. Cheng-Wen Lin, B. E. Foley, K. Carbajal, C. Kopczynski. Aerie Pharmaceuticals, Inc., Durahm, NC *CR

6126 — C0245 Protective Effects of Lipoxins A4 and B4 on the Inner Retina in a Chronic Mouse Model of Ocular Hypertension. Hsin-Hua Liu1, J. M. Sivak2, K. Gronert1, J. G. Flanagan1. 1School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA; 2Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada

6127 — C0246 fMRI shows Functional Recovery by Intravitreal Brimonidine Drug Delivery System (Brimo DDS Generation 1) in a Rabbit Model of Retinal Ganglion Cell (RGC) Degeneration. Corine Ghosn, J. A. Burke. Biological Sciences, Allergan, Inc, Irvine, CA *CR

6128 — C0247 A neuroprotective role of IGFBPL1 in glaucoma. Xin Wei, K. Cho, S. Guo, D. F. Chen. Department of Ophthalmology, Schepens Eye Research Institute, Boston, MA


6129 — C0248 The effect of VGF nerve growth factor inducible on retinal ganglion cell injury after optic nerve crush in mice. Masamitsu Shimazawa1, H. Takeuchi1, S. Inagaki1, 2, W. Morozumi1, Y. Nakano1, Y. Inoue1, Y. Kuse1, T. Mizoguchi1, M. Funato2, H. Kaneko2, H. Hara1. 1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan; 2Department of Clinical Research, National Hospital Organization, Nagara Medical Center, Gifu, Japan

6130 — C0249 Novel engineered VEGF variant for glaucoma. Junhui Shen1, 2, P. Baranov1, R. Xiao1, Y. Ng1. 1Harvard Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA; 2Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

6131 — C0250 Topical rh-NGF is neuroprotective to retinal ganglion cells by targeting secondary degeneration. Li Guo1, B. Davis1, N. Ravindran1, J. Galvao1, N. Kapoor1, N. Haamedi1, M. Cordeiro1, 2. 1Visual Neuroscience, UCL, Institute of Ophthalmology, London, United Kingdom; 2Western Eye Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom *CR

6132 — C0251 QTA020V, a novel rAAV2 vector, reduces retinal ganglion cell body and axon loss in rats with laser-induced intraocular pressure elevation. Peter S. Widdowson1, A. Osborne2, 1, T. Khatib2, K. Hall2, K. R. Martin2, 1. 1Quethera Ltd, Cambridge, England, United Kingdom; 2Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom *CR

6133 — C0252 Sustained up-regulation of neuroprotective intracellular signalling pathways in retinal ganglion cells following intravitreal injection of QTA020V, a novel rAAV2 vector. Andrew Osborne1, 2, L. Songra1, P. S. Widdowson2, K. R. Martin1, 2. 1School of Clinical Neuroscience, University Of Cambridge, Cambridge, England, United Kingdom; 2Quethera Ltd, Cambridge, England, United Kingdom *CR

6134 — C0253 Neuroprotective effect of TrkB agonist antibody in humanized TrkB rat. Henry Chen3, A. Latuszek3, Y. Hu3, J. Lee1, W. Poueymirou1, J. Cao3, W. Olson2, B. Zambrowicz1, C. Romano3. 1Velocigene, Regeneron Pharmaceuticals, Inc, Tarrytown, NY; 2Therapeutic Proteins, Regeneron Pharmaceuticals, Inc, Tarrytown, NY; 3Opthalmology, Regeneron Pharmaceuticals, Inc, Tarrytown, NY *CR

6135 — C0254 AAV mediated delivery of NT4 specifically to Müller glial cells promotes retinal ganglion cell survival in the DBA/2J mouse model of glaucoma. Anna M. Demetriades1, C. Pan1, L. Byrne3, J. Harder2, S. W. John2, J. G. Flannery3. 1Ophthalmology, Weill Cornell Medicine, New York, NY; 2The Jackson Laboratory, Bar Harbor, ME; 3Helen Wills Neuroscience Institute, Berkeley, CA

6136 — C0255 Effect of XIAP gene therapy in an experimental model of glaucoma. Shagana Visuvanathan2, 1, A. N. Baker2, 4, P. Lagali2, 4, S. G. Coupland3, 4, G. Miller3, 4, C. Tsilfidis2, 3. 1Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada; 2Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 3Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada; 4University of Ottawa Eye Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

6137 — C0256 Neuroprotection by overexpression of transcription factor Max in experimental glaucoma. Rafael Lani1, M. S. Dias1, T. G. Araujo1, W. W. Hauswirth2, A. M. Dantas1, M. Fiorani Junior1, H. Petrs Silva1, R. Linden1. 1Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Department of Ophthalmology Research, University of Florida, Gainesville, FL

6138 — C0257 Ecel1 expression is promoted by damage to axonal flow and protects retinal ganglion cells after optic nerve crush in mice. Kota Sato, Y. Nakagawa, H. Tawarayama, N. Murayama, Y. shiga, K. Fujita, K. M. NIshiguchi, T. Nakazawa. Ophthalmology, Tohoku University, Sendai, Miyagi, Japan *CR

6139 — C0258 A small peptide inhibitor of the Fas receptor prevents axon degeneration and death of retinal ganglion cells in a microbead-induced mouse model of glaucoma. Meredith S. Gregory-Ksander1, A. J. Kocab3, D. N. Zacks2, A. krishnan1. 1Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary/HMS, Boston, MA; 2Kellogg Eye Center, University of Michigan, Ann Arbor, MI; 3ONL Therapeutics, Ann Arbor, MI *CR

6140 — C0259 Neuroprotective outcomes of immunomodulation by transgenic inhibition of astroglial NF-κB may involve increased glial metabolic support. Gulgun Tezel1, X. Yang1, J. Cai2, J. B. Klein2. 1Ophthalmology, Columbia University, New York, NY; 2Medicine, University of Louisville, Louisville, KY

6141 — C0260 Delayed blockade of retinal gap junctions still promotes neuroprotection in a mouse model of glaucoma. Abram Akopian, S. Kumar, H. Ramakrishnan, S. A. Bloomfield. SUNY College of Optometry, New York, NY

6142 — C0261 Immune tolerance to HSP60 attenuates neurodegeneration in a mouse model of glaucoma. Eric F. Thee1, 2, K. Cho1, M. J. Jager2, D. F. Chen1. 1Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 2Ophthalmology, Leiden University Medical Center, Leiden, Netherlands

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6143 — C0262 Fc Receptors involved in neuroprotective γ- Synuclein antibody transport into retinal Müller cells. Katharina Bell, C. Wilding, I. Rosignol, N. Pfeiffer, F. H. Grus. Experimental Ophthalmology, Medical Center University of Mainz, Mainz, Germany

6144 — C0263 Autotaxin protects retinal ganglion cells in an autoimmune glaucoma model. Stephanie C. Joachim1, S. Reinehr1, G. Stute1, C. Ullmer2, H. Dick1. 1Experimental Eye Research Institute, Ruhr University, Bochum, Germany; 2Roche Pharma Research & Early Development, F. Hoffmann-La Roche AG, Basel, Switzerland *CR

6145 — C0264 Statins regulate MMP-2 and MMP-9 secretion and activation in human ONH astrocytes. Milyang Kim, J. Shin, K. Sung. Seoul Asan Medical Center, Seoul, Korea (the Republic of)

6146 — C0265 Functional Analysis of MANF in Retinal Ganglion Cells by Oxidative Stress. Mina Mizukami, J. Ko, D. G. Ibrahim, H. Okumichi, Y. Kiuchi. Ophthalmology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

6147 — C0266 DMP-543 increases cell survival in the mammalian retina by enhancing ACh release. David Linn, A. Ramo, L. Lusardi, L. Schroedter, G. Peterson. Biomedical Sciences, Grand Valley State University, Allendale, MI

6148 — C0267 The activation of mGluR5 against retinal neuron death in retinal ischemia/reperfusion model. Zuohong Li, Y. Jia, W. Su, Y. Zhuo. zhongshan ophthalmic center, Guangzhou, China

6149 — C0268 Primary Cilia Enhances Retinal Ganglion Cell Survival after Axotomy by Abortive Cell Cycle Inhibition. Brian Choi, P. M. D’Onofrio, P. D. Koeberle. Surgery, University of Toronto, Toronto, Ontario, Canada

6150 — C0269 MEF2D activation by mAKAP signalosomes promotes neurite outgrowth and RGC survival. Caroline Yu, S. Shah, J. Galvao, M. Atkins, M. Kapiloff, J. L. Goldberg. Ophthalmology, Stanford University, Stanford, CA

6151 — C0270 The Effects of Zeaxanthin on Adult Zebrafish Vision in Both Normal and Glaucoma Fish. Johnny T. Pham2, P. G. Davey1, D. Cameron1. 1College of Optometry, Western University of Health Science, Pomona, CA; 2Graduate College of Biomedical Sciences, Western University of Health Science, Pomona, CA *CR

6152 — C0271 Genetic deletion of DLK and LZK reduce colchicine-induced cell death in human stem cell-derived retinal ganglion cells. Pingwu Zhang1, Y. Duan1, J. Cheng1, C. Berlinicke1, A. K. Patel2, D. S. Welsbie2, D. J. Zack1. 1Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 2Ophthalmology, University of California San Diego [email protected], La Jolla, CA


Thursday, May 03, 2018 11:00 AM-12:45 PMClinical/Epidemiologic Research

542 Medical education, training and telemedicine

Moderator: Jessie Huang

6153 — C0272 Modeling a National Telemedicine Screening Program for Diabetic Retinopathy in Iran and Implementing a Pilot Project. Sare Safi1, 2, H. Ahmadieh1, M. Katibeh2, 3, M. Yaseri1, 4, H. Nikkhah1, 5, S. Karimi1, 5, R. Nourinia1, A. Tivay6, M. Zareinejad6, D. Abbasi7, A. Eshghi Fallah1, B. Kheiri1. 1Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 2Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 3Center for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark; 4Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 5Department of Ophthalmology, Torfeh Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 6New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran (the Islamic Republic of); 7Iranian Diabetes Society, Islamshahr, Iran (the Islamic Republic of)

6154 — C0273 Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: Adherence to Community Eye Exam Appointments. Lisa A. Hark2, 1, L. Katz2, J. S. Myers2, J. A. Haller3. 1Ophthalmology, Columbia University Medical Center, Lafayette Hill, PA; 2Glaucoma Research, Wills Eye Hospital, Philadelphia, PA; 3Ophthalmologist-in-Chief, Wills Eye Hospital, Philadelphia, PA f

6155 — C0274 Non-mydriatic camera vs OCT for the detection of diabetic macular edema. David Rivera1, 2, A. Jimenez-Corona1, S. Hernandez-Jimenez2, P. Almeda-Valdes2, L. Perez-Peralta1, V. Y. Zurita-Cortes2, S. E. Cardenas-Gonzalez1, E. O. Graue-Hernandez1. 1Retina, Insituto de Oftalmologia Fundacion Conde de Valenciana, Mexico, Mexico; 2Instituto Nacional De Ciencias Medica y Nutricion Salvador Zubiran, Mexico, Mexico

6156 — C0275 Measuring The Appropriateness Of Eye Care In Australia: Protocol For A Retrospective Record Review. Kam Chun Ho1, D. Rahardjo1, F. Stapleton1, W. Louise2, 3, P. Hibbert2, 3, A. J. White4, 5, G. Liew5, I. Jalbert1. 1School of Optometry and Vision Science, UNSW Sydney, Sydney, New South Wales, Australia; 2Faculty of Medicine and Health Sciences, Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia; 3Centre for Population Health Research, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia; 4Save Sight Institute, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia; 5Centre for Vision Research, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia

6157 — C0276 Primary care physicians’ recall of diagnostic and treatment qualities of glaucoma: effect of an educational program. Kirsten Midgley1, M. Summerfield1, 2. 1Georgetown University/Washington Hospital Center, Washington, District of Columbia; 2Washington Eye Institute, Riverdale, MD

6158 — C0277 Student perceptions of the ophthalmology curriculum in medical school. Lucy Cobbs1, E. Tsui2, I. Haberman2, E. Kim2, L. Sperber2, M. Wu2, J. Schuman2. 1New York University School of Medicine, New York, NY; 2Ophthalmology, New York University School of Medicine, New York, NY

6159 — C0278 Development of a curriculum for teaching glaucoma to ophthalmology residents: A needs assessment. George C. Papachristou1, J. Meka2. 1Ophthalmology, Penn State Eye Center, Hershey, PA; 2Woodward Center for Excellence in Health Sciences Education, Penn State College of Medicine, Hershey, PA

6160 — C0279 Medical Education in the Digital Era: Feasibility and Design of an Open-Access Online Ophthalmology Curriculum. Nikitha Murali, N. Kombo, S. Forster. Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT

6161 — C0280 Integrated Ophthalmology-General Surgery Internship Educational Impact. Lesley Everett, S. Ramanathan. Ophthalmology, University of California, San Francisco, San Francisco, CA

6162 — C0281 Creating an Ophthalmology Curriculum for Emergency Medicine Physicians. Deepak Sambhara1, C. Wright1, J. Nunn1, E. B. Werley2, M. J. Wilkinson1, S. Pantanelli1. 1Dept of Ophthalmology, Penn State Eye Center, Hummelstown, PA; 2Emergency Medicine, Penn State College of Medicine, Hershey, PA



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6163 — C0282 Virtual Eye Surgery Training in Ophthalmic Graduate Medical Education. Samantha K. Paul1, M. A. Clark4, I. U. Scott5, P. B. Greenberg2, 3. 1Alpert Medical School, Providence, RI; 2Division of Ophthalmology, Brown University, Providence, RI; 3Section of Ophthalmology, Providence Veterans Affairs Medical Center, Providence, RI; 4Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA; 5Departments of Ophthalmology and Public Health Sciences, Penn State College of Medicine, Hershey, PA

6164 — C0283 The Effect of Regular Practice with a Low-cost Simulator on Surgical Skills and Confidence. Emily W. Gower1, S. Tulenko1, W. Alemayehu2, D. Tadesse3, B. Bayissasse1, A. Sisay4, F. Admassu5. 1Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC; 2Berhan Health Consulting, Addis Ababa, Ethiopia; 3CBM, Addis Ababa, Ethiopia; 4Personal Consulting, Addis Ababa, Ethiopia; 5Gondar University, Gondar, Ethiopia f

6165 — C0284 Quantifying the Impact of Research on Matching Into Ophthalmology Residency. Albert Bargoud1, L. Thangmathesvaran1, V. R. Patel1, A. S. Khouri2. 1Rutgers New Jersey Medical School, Newark, NJ; 2Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ

6166 — C0285 Ophthalmology Urgent Care Preceptorship: Building Medical Student Ophthalmic Knowledge and Developing Residents-as-Teachers. mona L. Camacci1, R. Rolius1, S. D. Kim2, P. Nguyen2, V. Nguyen2, J. Liechty2, A. Westcott3, D. A. Quillen1, S. Pantanelli1. 1Ophthalmology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA; 2Pennsylvania State College of Medicine, Hershey, PA; 3Woodward Center for Excellence in Health Sciences Education, Penn State Health Milton S. Hershey Medical Center, Hershey, PA *CR

6167 — C0286 Assessment of mentorship needs during ophthalmology residency. Edmund Tsui1, C. Lo2, E. Kim1, I. Haberman1, L. T. Sperber1, A. Madu1, D. Lazzaro1, J. Schuman1. 1Ophthalmology, New York University School of Medicine, New York, NY; 2Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, CA

6168 — C0287 Resident Wellness in United States Ophthalmic Graduate Medical Education: The Resident Perspective. Elaine M. Tran2, 1, I. U. Scott4, M. A. Clark3, P. B. Greenberg1, 5. 1Division of Ophthalmology, Warren Alpert Medical School of Brown University, Providence, RI; 2Program in Liberal Medical Education, Brown University, Providence, RI; 3Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worchester, MA; 4Departments of Ophthalmology and Public Health Sciences, Penn State College of Medicine, Hershey, PA; 5Section of Ophthalmology, Providence Veterans Affairs Medical Center, Providence, RI

6169 — C0288 Diversity in the Vision Research Community. Charles Wright, N. Agarwal, C. E. Perez-Gonzalez, D. M. Schneeweis. Office of the Scientific Director, National Eye Institute, Bethesda, MD

6170 — C0289 Differences in practice of ophthalmology by gender in Australia. Tiffany Lo1, A. J. Hall3, L. L. Lim1, 2. 1The Centre for Eye Research Australia, St Kilda East, Victoria, Australia; 2The Royal Victorian Eye and Ear Hospital Melbourne, Melbourne, Victoria, Australia; 3Ophthalmology, The Alfred Hospital, Melbourne, Victoria, Australia *CR

6171 — C0290 Difference-in-Differences Analysis of the Association between Publicly Reporting Physician-Industry Relationships and Industry Payments to Ophthalmologists. Dan Gong1, J. S. Chang2. 1Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY; 2Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI

6172 — C0291 Academic Ophthalmology Departments and their use of Facebook, Instagram and Twitter Social Media Pages. Robert F. Melendez1, 2, P. Angadi3, 1, E. Sledz1, G. Acosta1, M. Griego1, M. Sherpa1, C. Teng1. 1Surgery/Ophthalmology, University of New Mexico Health Sciences Center, Albuquerque, NM; 2Eye Associates of NM, Albuquerque, NM; 3Ophthalmology, Howard University, Washington, District of Columbia *CR



543 Trauma and Endophthalmitis

Moderator: Dennis P. Han

6173 — C0292 Post-surgical versus post-intravitreal injection endophthalmitis: changing patterns in causative flora. Matthew P. Simunovic1, 2, A. P. Ong1, 2, N. Angbue Te2, W. Yates1, 2, R. Symes1, 2, S. Zagora1, 2, P. J. McCluskey1, 2, A. Chang1, 2. 1Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia; 2Sydney Eye Hospital, Sydney, New South Wales, Australia

6174 — C0293 The effect of Abusive Head Trauma on the Retina and Its Implication for retinal hemorrhage Using 3D Finate Element. Donny W. Suh1, L. Gu2, H. Mozafari2, H. Song3. 1Department of Ophthlamology, University of Nebraska, Omaha, NE; 2Biomedical Engineering, University of Nebraska, Lincoln, NE; 3University of Nebraska Medical School, Omaha, NE

6175 — C0294 Post traumatic endophthalmitis with intraocular foreign bodies in children in southern China: Epidemiology, prognostic factors and clinical outcomes. Yao Yang1, 2, X. Lin1, 2, C. Yang3. 1Zhongshan Ophthalmic Center,Sun Yat-sen University, Guangzhou, Guangdong, China; 2State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China; 3The Fifth Affiliated Hospital Of Sun Yat-Sen University, Zhuhai, China

6176 — C0295 Complications and Visual Outcomes of Intraocular Foreign Bodies. Sahas Narain1, W. Wang2, H. Sandhu2. 1University of Louisville School of Medicine, Louisville, KY; 2Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY

6177 — C0296 Ocular TASER Trauma. Stavros N. Moysidis1, 2, N. Koulisis3, 2, D. C. Rodger2, 4, B. Burkemper2, G. A. Williams1, M. S. Humayun2, 4, D. Eliott5. 1Associated Retinal Consultants, Oakland University William Beaumont School of Medicine, Royal Oak, MI; 2USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA; 3William Beaumont Hospital, Royal Oak, MI; 4USC Institute for Biomedical Therapeutics, Lo, CA; 5Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA

6178 — C0297 Morphological Analysis of Ovine Retinal Vasculature to Assess Risk for Retinal Hemorrhage as a Function of Age. Brittany Coats, M. Byrne. Mechanical Engineering, University of Utah, Salt Lake City, UT

6179 — C0298 Outcomes of Intraocular Foreign Body Injuries. David Kilpatrick, J. Burnham, C. J. Chen. Ophthalmology, University of Mississippi Medical Center, Jackson, MS

6180 — C0299 Preliminary Optical Coherence Tomography Findings in Abusive Head Trauma (Shaken Baby Syndrome). Maryo Kohen, F. Orge. Department of Ophthalmology, Case Western Reserve University, Beachwood, OH

6181 — C0300 Same day pneumotonometry might be a risk for endophthalmitis after small gauge pars plana vitrectomy. Shwu-Jiuan Sheu2, 1, C. Tseng2. 1Ophthalmology, National Yang Ming University, Kaohsiung, Taiwan; 2Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Taiwan

6182 — C0301 Etiology and antimicrobial trends over time in infections endophthalmitis. Austin D. Igelman, J. Simonett, S. Taylor, C. J. Flaxel. Casey Eye Institute, Oregon Health & Science University, Portland, OR


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6183 — C0302 Does size really matter? Comparing rates of endophthalmitis following intravitreal injections using 30 vs. 32 gauge needles. Ilyse Kornblau1, H. Pasha1, C. Andersen2, J. El-Annan1. 1Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX; 2Office of Biostatistics, Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX

6184 — C0303 Absence of posterior vitreous detachment as a possible risk factor of severe bleb-related endophthalmitis. Ryo Baba, K. Umazume, H. Goto. Ophthalmology, Tokyo Medical University, Shinjyukuku, Tokyo, Japan

6185 — C0304 Endophthalmitis Rates after Bilateral Same Day Intravitreal Anti-VEGF Injections. Durga S. Borkar, A. Obeid, D. Su, P. Storey, X. Gao, R. Kaiser, S. Garg, J. Hsu. Retina Service, Wills Eye Hospital, Philadelphia, PA

6186 — C0305 Clinical features, antibiotic susceptibility profiles, and outcomes of postoperative endophthalmitis caused by Achromobacter xylosoxidans : importance of aggressive surgical removal of capsular bag. Joong Hyun Park1, D. Kim2, J. Kim1. 1Department of Ophthalmology, Jeju National University Hospital, Jeju-si, Jeju Self-Governing Province, Korea (the Republic of); 2Department of ophthalmology, Chungbuk National University Hospital, Cheongju, Korea (the Republic of)

6187 — C0306 Rates of post-injection endophthalmitis with 5% vs. 10% povidone-iodine preparation. Zachary Mills1, C. A. Harper2, 1, J. A. Martinez2, 1, J. Dooner2, 1, M. Levitan2, 1, P. A. Nixon2, 1, R. Wong2, 1, R. C. Young2, S. Day Ghafoori2, 1. 1Dell Medical School, Austin, TX; 2Austin Retina Associates, Austin, TX

6188 — C0307 Comparing Traditional Gram Stain to Cytospin-Enhanced Cytology of Vitreous Samples in Patients with Endophthalmitis. Michael Jansen, J. V. Giovinazzo, N. S. Mehta, C. Iacob, D. Gologorsky, R. B. Rosen, A. Deobhakta. Ophthalmology, New York Eye and Ear, New York, NY *CR

6189 — C0308 The Comparative Incidence of Endophthalmitis Following Intravitreal Injection with Bevacizumab, Ranibizumab and Aflibercept. Brian L. VanderBeek1, J. Bavinger1, Y. Yu2. 1Retina, Scheie Eye Institute University of Pennsylvania, Philadelphia, PA; 2Ophthalmology, Center for Preventive Ophthalmology and Biostatistics, University of Pennsylvania, Philadelphia, PA

6190 — C0309 Quantifying Ocular Manifestations in Abusive Head Trauma. Helen Song1, H. Mozafari2, P. Deegan1, L. Gu2, D. W. Suh1, 3. 1University of Nebraska Medical Center, Omaha, NE; 2Mechanical and Materials Engineering, University of Nebraska - Lincoln, Lincoln, NE; 3Pediatric Ophthalmology, Children’s Hospital and Medical Center, Omaha, NE



545 Image-guided Laser Applications and Lasers in Retinal Therapy

Moderator: Edoardo Midena

6191 — C0345 Subthreshold Laser Photocoagulation using a Conventional Pattern Scan Laser to Treat Macular Edema. Tomoyasu Shiraya1, S. Kato1, F. Araki1, A. Tsutsumi2. 1Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan; 2Tsutsumi Eye Clinic, Tokyo, Japan

6192 — C0346 Computer-Navigated Focal Macular Laser in the Treatment of Central Serous Chorioretinopathy. Matthew S. Katz, T. Choudhury. National Retina Institute, Towson, MD

6193 — C0347 3-year results of short-duration multiple-session subthreshold micropulse yellow laser (577-nm) for chronic central serous chorioretinopathy. Han Sang Park, S. Kim, O. Kwon, Y. Kim. Nune eye hospital, Daegu, Kyungpook, Korea (the Republic of)

6194 — C0348 What can Adaptive Optics do for Laser Photocoagulation? Pedro Mecê1, 2, C. Petit1, E. Gofas Salas1, 3, L. Mugnier1, K. Grieve3, 4, C. Chabrier2, J. A. Sahel3, 5, M. Paques3, 4, S. Meimon1, 4. 1ONERA - The French Aerospace Lab, Châtillon, France; 2Quantel Medical, Cournon d’Auvergne, France; 3Vision Institute, Quinze-Vingts Ophthalmology Hospital, Paris, France; 4Paris’ Group : Paris Adaptive-optics for Retinal Imaging and Surgery, Paris, France; 5Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, France *CR

6195 — C0349 Retinal and choroidal perfusion status following laser coagulation assessed with Swept Source Optical Coherence Tomography Angiography. Sonja Karst, C. Mitsch, R. Scharinger, C. Scholda, U. Schmidt-Erfurth. Department of Ophthalmology, Medical University Vienna, Vienna, Austria

6196 — C0350 3D simulation of pan-retinal laser photocoagulation for calculating the photocoagulation index using optical analysis software. Kentaro Nishida, H. Sakaguchi, K. Nishida. Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

6197 — C0351 Nd:YAG effects on Vitreous in Patients with Vision Degrading Vitreopathy. Jeannie Nguyen-Cuu1, J. Nguyen1, K. M. Yee1, J. Mamou2, J. Ketterling2, J. Sebag1. 1VMR Institute for VItreous Macula Retina, Huntington Beach, CA; 2Lizzi Ctr for Biomedical Engineering, Riverside Research, New York, NY

6198 — C0352 OCTA-guided Navilas therapy for choroidal neovascular membranes. francesca amoroso, A. Pedinielli, R. Blanco Garavito, P. Astroz, A. Miere, F. Gherdaoui, E. H. Souied. Ophtalmology, Hopital Intercommunal de Creteil, Creteil, France

6199 — C0353 Comparison and analysis of micropulse and continuous wave laser application on retinal pigment epithelium (RPE) ex vivo. Ralf Brinkmann1, 2, K. Inagaki3, B. Schmarbeck2, A. Hutfilz2, K. Bliedtner2, K. Ohkoshi3, Y. Miura1, 2. 1University of Luebeck, Luebeck, Germany; 2Medical Laser Center Luebeck, Luebeck, Germany; 3St. Luke’s International Hospital, Tokyo, Japan

6200 — C0354 Photocoagulation laser control using phase-sensitive optical coherence tomography toward laser lesion management. En Li, S. Makita, Y. Yasuno. Computational Optics Group, University of Tsukuba, Tsukuba, Japan *CR

6201 — C0355 Comparison of pain and duration of panretinal photocoagulation using conventional multispot laser and Navigated laser. Alexandre Pedinielli, F. Amoroso, P. Astroz, E. Bruyere, E. H. Souied. Ophthalmology, CHI Créteil, Créteil, France

6202 — C0356 Measurements of retinal temperature using Laser Speckle Imaging (LSI). Nicole Sevilla1, I. Saytashev2, P. Lopez2, J. Chue-Sang1, H. Wertheim2, J. Ramella-Roman2, 1. 1BME, Florida International University, Miami, FL; 2Herbert Wertheim College of Medicine, Ophthalmology, Florida International University, Miami, FL


Thursday Award Lecture

1:00 pm – 2:00 pm


Thursday – Award Lecture

Ballrooms BC

Thursday, May 03, 2018 1:00 PM-2:00 PM

546 Beckman-Argyros Award in Vision Research

— 1:00 Introduction: Anne Hultgren

— 1:10 James G. Fujimoto, PhD: History, Evolution and Future Prospects of Optical Coherence Tomography

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Thursday – Keynote Session

Ballrooms BC

Thursday, May 03, 2018 2:15 PM-3:45 PM

547 ARVO/Alcon Keynote Session: Principles of gene repair in human embryos

In vitro fertilization (IVF) represents a successful cell therapy approach for treatment of infertility. However, IVF is increasingly utilized for preimplantation genetic diagnosis (PGD) followed by embryo selection to prevent the transmission of heritable human diseases. Our Center is actively investigating novel germ line gene therapy approaches that would allow to repair gene defects in mutant gametes or early preimplantation embryos. We are focused on answering important safety and efficacy questions regarding techniques that could one day be useful in preventing thousands of inherited genetic disorders that affect millions of people worldwide. The focus of this lecture is to inform on applications of gene editing and gene replacement strategies in preclinical and clinical studies demonstrating feasibility, efficacy and long-term safety of germ line gene therapy.

— 2:15 Principles of gene repair in human embryos: Shoukrat Mitalipov, OHSU

thursday · — 8:15 introduction ... department of ophthalmology, university of auckland,...

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