Thymus and Spleen

Dr. Raid Jastania

Dec 2006

• By the end of this session you should know the clinical and pathological features of – Thymic hyperplasia– Thymoma

• List the causes of splenomagaly

Thymus

• Hyperplasia– Usually asymptomatic, incidental or associated

with Myasthenia Gragis– Other autoimmune diseases: SLE, Rheumatoid– Pathology: enlargement of the thymus with

lymphoid follicles with germinal centers

Thymus

• Thymoma:– Epithelial neoplasm of the thymus

– Types:• Benign

• Malignant type1: invasive thymoma

• Malignant type2: thymic carcinoma

– Clinical: Mass lesion

– Pathology: enlarged thymus, lobulated mass with fibrous septation. Epithelial tumor mixed with lymphoid cells. (cortical, medullary)

Spleen

• What are the causes of splenomegaly?

List of Causes

• Primary vs Secondary

• Congenital/Genetic vs Acquired

• The Acquired: Non-neoplastic, Neoplastic

• Non-neoplastic: Inflammatory, Idiopathic

• Inflammatory: Infection, Drugs, Toxins, Metabolic, Immune

Congestion

Large cell lymphoma

CLL

Angiosarcoma

Gaucher Disease

Spleen

• What are the features of hypersplenism?

Symptoms and Signs

• Primary, Secondary, Non specific

• Anatomical and Functional

• Complications of the disease process

• By the end of this session you should know the clinical and pathological features of – Thymic hyperplasia– Thymoma

• List the causes of splenomagaly