tick talk march 29th - kingston academy of medicinetick talk march 29th 2012 kieran moore fcfp frcpc...
TRANSCRIPT
Tick Talk
March 29th 2012
Kieran Moore FCFP FRCPC
Objectives-through cases
• Epidemiology-LOCAL
• Engorged or not engorged pathway?
• Clinical presentation and treatment of lyme disease…basics
Ontario-Lyme cases
Patient 1 • 18 year old male presents with tick on groin
for unknown time.
• He had been to Lemoine’s point.
• No symptoms except local inflammation at bite.
• What do you do?
• What is his risk of Lyme disease?
Patient 1:Removal
Patient 1:Removal
Swinging!
Partially or unfed ticks
Fed ticks
Epidemiology
Black legged tick-ADULT
PATIENT-over 12
Engorged?24-72 hours
Adult tick
Decreased benefit of
prophylaxis
Nymph
Prophylaxis option
Non engorged!-less than 24
hours
Remove and monitor
Ixodes life cycle
Black legged tick-(98 percent IS), NEJM 482
Engorged, more than 72 hours,
248
Adult tick
0/97
Nymph
8/142 (3.2% overall)
> 72 hours, engorged, DOXY
235
1of 235 EM (0.4%)
Risk reduction-Primary Prevention
• RRR=1-0.4/3.2=87%
• ARR=2.8%
• NNT=1/ARR=36
• Meta analysis suggest NNT of 50
• Risk of EM/Lyme in a bite of IS-3.2 percent in Westchester County NY ( 2.2%) in meta analysis) -One in fifty chance
Key points-STUDY • Engorged nymph-72 hours
• Overall 2.2-3.2 percent risk doing nothing and waiting
• Non pregnant Adult patients only- not studied in children less than 12
• Doxy-30 % side effect profile
• A single dose of 200 mg DOXY within 72 hours can prevent the development of LYME disease
Black legged tick-0ver 12
y.o.=ADULT PATIENT
Engorged?-72 hours
Adult tick
Decreased benefit of prophylaxis
Nymph
Prophylaxis option
Non engorged! less than 24 hours
Remove and monitor
Patient 2
• 18 year old female presents with fever, arthralgia,rash, FAR after camping.
• She remembers a tick bite five days ago.
• What is your approach?
Lyme Disease
Timing-USA
PHAC study-FAR
CDC Symptoms
One to two weeks-3 to 30 days, can last 8 weeks
Expanding-5 cm or greater
FAR:Summer Palsy....Knee effusion
National Guideline
• Since there is currently no definitive test for Lyme disease, laboratory results should not be used to exclude an individual from treatment.
• Lyme disease is a clinical diagnosis and tests should be used to support rather than supersede the physician’s judgment.
• The early use of antibiotics can prevent persistent, recurrent, and refractory Lyme disease.
• REPORTABLE to Public health
Lyme Disease-Practice guidelines • Adult:
• First Line: Amoxil 500 tid or Doxy 100 bid
• Usual duration 14-21 days
• Children:
• Amoxil 50 mg/kg/day divided q8h
• Cefuroxime 30 mg/kg/day divided q12 h
• NOT CEPHALEXIN
IV therapy-CCA
• Acute neurological-radiculopathy, meningitis
• 3rd degree heart block
• Arthritis-effusion
• REFER
Lyme NEURO involvement
• Consider whenever neurologic disease occurs with constitutional symptoms-FAR
• 10-40 percent of symptomatic infections at ALL stages
• Blood tests may take 4-6 weeks to turn positive
Testing
Protection
Prevent
Conclusion
• Prophylaxis is based on risk and feed time-engorged versus not engorged
• Clinical diagnosis!
• Use guidelines!
• PLEASE CALL US-REPORTABLE