342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 1/6

CARIM Newsletter April 2017 View this email in your browser

This newsletter containsinformation on the followingsubjects:

Tilman HackengScientific DirectorPrize FMS MR CLEANParamount PapersCARIM PostdoctoralTalent FellowshipGrant deadlinesCardiovascular GrandRounds MaastrichtSymposia & otherlecturesAcademic eventsMedia moments

CARIM newsletter Contributions for the newsletter (e.g. news of events and grants,

important publications, societial impact related topics and research

results related to CARIM's research) can be sent to carim

office@maastrichtuniversity.nl. Please submit the text in English and

include a short title. The text should be max. 200 words. If

applicable, include high resolution pictures and other documents.

As from December, two regular sections are added: "Paramount

papers" and Translational trends". So, if you have a top

publication or a translational development worth mentioning,

please contact CARIM Office.

Tilman Hackeng Scientific Director CARIMAs from April 1, 2017, Professor Tilman Hackeng successes Professor Thomas Unger as Scientific Director of CARIMfor a term of six years.

Tilman Hackeng studied chemistry (major biochemistry) at the University ofUtrecht, The Netherlands. He obtained his Ph.D. with Prof. Bouma at the sameUniversity in 1993. Shortly after, he left for The Scripps Research Institute, LaJolla, CA, USA, where he worked in the laboratories of Profs. Griffin (Mol & ExpMedicine) and Kent (Chemistry). In 1998 he returned to the Netherlands as aResearch Fellow of the Royal Netherlands Academy of Arts and Sciences(KNAW) at the Department of Biochemistry with Prof. Rosing at theCardiovascular Research Institute of the University Maastricht (CARIM).Currently, he is head of the Department of Biochemistry and board member ofCARIM. He is past president of the Netherlands Society on Thrombosis andHemostasis (NVTH) and elected member of the Royal Holland Society ofSciences and Humanities (KHMW). He has published 141 papers with an hindex of 41 (WoS). Prof. Hugo ten Cate has taken over the leadership of Theme I as from April1.

Subscribe Share Past Issues Translate

342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 2/6

MR CLEAN wint prijs van Federatie MedischSpecialisten Het gezamenlijke MR CLEANonderzoek van neurologen en radiologen naar intraarteriële trombectomie van eenacuut herseninfarct heeft de Wetenschaps en Innovatieprijs van de Federatie Medisch Specialisten (FMS)gewonnen. De winnaars namen hun prijs in ontvangst tijdens het congres Medisch Specialist 2025.

Zij voerden een multidisciplinair onderzoek uit naar de effectiviteitvan deze relatief nieuwe techniek, waarbij een afgeslotenhersenbloedvat via katheterisatie wordt geopend. Dit is effectieverdan intraveneuze trombolyse, bij de patiënten die ervoor inaanmerking komen. De endovasculaire behandeling vindt steedsvaker plaats in Nederland. De jury vond de MR CLEANstudieboven de andere inzendingen uitspringen vanwege hetgrensverleggende karakter ervan, de impact op de patiënt envanwege de vak en ziekenhuisoverstijgende samenwerking. De Raad Wetenschap & Innovatie van de FMS nam het initiatiefvoor de Wetenschaps en Innovatieprijs. Daarmee wil zijonderzoek, en samenwerking daarvoor, stimuleren, en de rol vande medisch specialist als onderzoeker belichten. Wim van Zwam (Radiology) and Robert van Oostenbrugge(Neurology) zijn de coördinatoren vanuit Maastricht binnen MRCLEAN Bronnen: https://www.medischcontact.nl/nieuws/laatstenieuws/artikel/mr

cleanwintprijsvanfederatiemedischspecialisten.htm https://www.zorgvisie.nl/Kwaliteit/Nieuws/2017/3/Nieuwebehandelingacuteherseninfarctwintprijs/

Paramount papersIntegration of multiple largescale “–omics”datasets yields mechanistic and etiologicalinsights into genetic variationTechnological innovations, including microarray and next generation sequencing platforms, enable theascertainment of very large datasets describing individual genomes, transcriptomes, and epigenomes (amongothers). To date, these “–omic” datasets, which allow for the hypothesisfree interrogation of manyvariants/molecules/etc., have been primarily analyzed individually. The integration of multiple such datasets,however, provides an opportunity to assess their interplay and make novel mechanistic and etiologicalinsights.

Subscribe Share Past Issues Translate

342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 3/6

To that end, the Biobankbased Integrating –Omics Study (BIOS), consisting of samples from across theNetherlands, was implemented. Genomic, transcriptomic, and methylation data was assessed inapproximately four thousand wellcharacterized individuals from six Dutch cohort studies. CARIM researcherAaron Isaacs and BIOS colleagues recently published backtoback Nature Genetics papers describing resultsfrom this effort. The first article demonstrates that approximately onethird of known disease and traitassociated genetic variants, often intronic, have effects on methylation in trans and suggests that the biologicalmechanism underlying transmethylation QTLs commonly involves a local effect on the expression of a nearbytranscription factor that influences DNA methylation at the distal binding sites of that particular transcriptionfactor. The second describes the systematic identification of contextdependent expression QTLs using ahypothesisfree strategy, which will help to detect unanticipated intrinsic factors and external stimuli that modifythe downstream effects of genetic risk factors. These papers are available online at: http://www.nature.com/ng/journal/v49/n1/full/ng.3721.html andhttp://www.nature.com/ng/journal/v49/n1/full/ng.3737.html.

MUMC+ study published in The Lancet questionshydration to prevent ContrastInducedNephropathy The interdisciplinary AMACING research group from the MUMC+ (Departments of Radiology & NuclearMedicine, Cardiology, Internal Medicine, Clinical Epidemiology and Health Technology Assessment, and UMDepartment of Epidemiology) recently published their results in The Lancet. Current national and international guidelines on the use of intravascular iodinated contrast material, such as isused in computed tomography or in coronary catheterizations and vascular interventions, recommendprophylactic hydration (intravenous hydration with normal saline for 412 hours before and after contrast) for allpatients with an eGFR<45mL/min/1.73m2, and for all patients with an eGFR<60mL/min/1.73m2 in combinationwith diabetes or >1 risk factor (age, cardiovascular disease, nephrotoxic medication or anaemia).Implementation concerns an estimated 612 million highrisk patients each year, and imposes quite a burdenon hospital logistics, health care budgets, and patient comfort. In the Netherlands these guidelines are imposed on hospitals quite strictly, and compliance is part of theannual quality assessment carried out by government instances. Yet, clinical and costeffectiveness of thisprophylactic hydration treatment in protecting renal function has not been adequately studied in the populationtargeted by the guidelines to date. The aim of the AMACING trial [A MAastricht ContrastInduced NephropathyGuidelines trial] , was to fill this gap, by testing the implemented guidelines against a group receiving noprophylaxis. This has never been tested before. Between June 17th, 2014 and July 17th, 2016 we prospectively included all adult patients referred for anelective procedure with intravascular iodinated contrast material and referred for prophylactic hydration. Weexcluded patients with eGFR below 30 mL/min/1.73m2, as well as dialysis, intensive care or emergencypatients. We randomized these patients to either receive standard prophylactic hydration according to theguidelines or to receive no prophylaxis. CIN incidence was 2.6% in the no prophylaxis group versus 2.7% in the standard prophylactic intravenoushydration group, 5.5% of iv hydrated patients suffered complications of the prophylactic intravenous hydration,and no instances of dialysis or related deaths were recorded within 35 days of contrast exposure. We found not giving prophylaxis to be noninferior to giving the prophylaxis, as well as costsaving. The latteramounts to a reduction in costs estimated at 50100 million euro a year in the Netherlands alone. Our resultsimply that, assuming optimal contrast administration (prewarmed, minimum dose, low osmolality, nonionic,monomeric contrast), one might consider not giving prophylaxis to the patient group we studied withoutcompromising patient safety. The results are an argument to revisit the current guidelines for the prevention ofcontrast induced nephropathy. The Lancet. Published Online: 20 February 2017. DOI: http://dx.doi.org/10.1016/S01406736(17)300570

Subscribe Share Past Issues Translate

342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 4/6

CARIM Postdoctoral Talent FellowshipLast year, CARIM has initiated a new fellowship to support talented PhD students in realizing an oneyear researchproject as a Postdoc. It has a budget to provide one year of competitive salary as a Postdoc and must be spent partlyat a foreign institute. CARIM PhD students that are in the fourth year of their PhD trajectory are eligible. The fellowship is intended to provide recently promoted, top CARIM talent a chance to gain experience abroad andreturn to CARIM to perform excellent research. It offers a competitive salary for a one year postdoctoral position. This fellowship is designed to support talented PhD students in realizing an ambitious, innovative and internationaloneyear research project as a Postdoc. As part of the grant you will be expected to go abroad for part of the postdocin collaboration with highimpact collaborators, gather international experience and write prestigious grants such asthe VENI. The application deadline for the fellowship is April 17, 2017, after which a preselection will be made. The fellowshipapplications will be defended during the CARIM course week (Wednesday June 21, 2017). Click here for more information and the application form.

Grant deadlinesDOWNLOAD HERE THE SUBSIDY CALENDAR FOR 2017 Kootstra Talent Fellowship Deadline April 1 (& October 1), 2017 Click here for more information CARIM Postdoctoral Talent Fellowship April 17, 2017 Click here for more information LNVH l'OréalUNESCO for women in science Deadline May 8, 2017 Click here for more information Click here to download the newly adjusted AXA Post Doctoral Fellowship application procedure 2016/2017 The calendar/overview of the prizes the FHML/UM would like to nominate candidates for is now avaibleon: https://researchoffice.mumc.maastrichtuniversity.nl/prizecalendar

Subscribe Share Past Issues Translate

342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 5/6

April 7 Prof. Alain Cribier, Rouen "From Experimental Science to Routine Application in The Modern Cathlab" Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3B3, level 3 Breakfast included! Registration not necessary Click here for an overview of all the CGRM lectures of the first quarter of 2017

Symposia & eventsLorentz workshop Life Sciences with Industry 2017 Leiden: April 37, 2017 Click here for more information Valorisation Day April 11, 2017 Click here for more information “Hack Your Future innovate your education” April 12, 2017 Click here for more information MERLN Lecture Prof. Dimitrios Stamatialis April 20, 2017 Click here for more information IMCARIM seminar Prof. Ivo Fridolin April 27, 2017 Click here for more information 3day course ‘Klinische predictiemodellen theorie en praktijk’, May 810, 2017 Click here for more information Biomedica Life Sciences Summit May 910, 2017 Click here for more information CTCM Congress May 11, 2017 Click here for more information Lecture Dr Jan Weber May 11, 2017 Click here for more information 51st Annual Scientific Meeting ESCI May 1719, 2017 Click here for more information 2nd joint meeting of the European Society for Microcirculation (ESM) and European Vascular BiologyOrganisation (EVBO), May 29June 1, 2017 Click here for more information Workshop "Crafting the Valorisation Paragraph for you... by Knowledge Transfer Office @Maastricht University June 2 & June 12, 2017 Click here for more information PhD / Postdoc course Advanced Optical Microscopy 1216, June 2017 Click here for more information Maastricht Microscopy Meeting (M3) on Advanced Optical Microscopy June 16, 2017 Click here for more information 8th International Conference on cGMP June 2325, 2017 (Bamberg/Germany) Click here for more information KNAW agenda April CARIM School Council meetings 2017: April 25, 11.0013.00h: UNS50 H1.319 (Paarse zaal) June 13, 13.3015.30h: UNS50 H1.331 (Bonte zaal) October 9, 11.0013.00h: t.b.d.

Academic events

PhD Conferral Rio Putra Juni, Wednesday April 19, 12.00 hours

Subscribe Share Past Issues Translate

342017 CARIM Newsletter April 2017

http://us10.campaignarchive2.com/?u=b165cf2171b83fa0e0f6b5b76&id=e47df1230d&e=918045fa51 6/6

PhD Conferral Rio Putra Juni, Wednesday April 19, 12.00 hours Supervisor: Prof. L. de Windt Cosupervisor: Dr P.A. da Costa Martins Title: "microRNAs as regulators of cardiac vascular remodeling" PhD Conferral Michael P.É. Clerx, Thursday April 20, 16.00 hours Supervisors: Prof. R.L.M. Peeters; Prof. P.G.A. Volders Cosupervisor: Dr P. Collins Title: "Multiscale Modeling and Variability in Cardiac Cellular Electrophysiology"

Media momentsDe 'stille aandoening' als killer, 01042017

Copyright © CARIM Maastricht University, All rights reserved. www.carimmaastricht.nl Our mailing address is: CARIMoffice@maastrichtuniversity.nl

Share Tweet Forward

This email was sent to t.dekoster@maastrichtuniversity.nl why did I get this? unsubscribe from this list update subscription preferences

CARIM · Universiteitssingel 50 · Maastricht, Li 6229 ER · Netherlands

Subscribe Share Past Issues Translate