tipsy neurons jackie barlow joseph esdin trish hartzell kalyani maitra miriam martin xia yang &...
TRANSCRIPT
Tipsy Neurons
Jackie BarlowJoseph EsdinTrish Hartzell
Kalyani MaitraMiriam Martin
Xia Yang&
Jim Burnette
NASI TidbitEducational context
1. sophomores biology majors in a physiology coursemid-semester
2. students have knowledge of Basic chemistry, biologyBasic molecular interactionsEnzyme-substrate
3. students will be expected to have read background information about neurons, synapses, neurotransmitters
Kalyani
Goals/Objectives:
After this class, students will understand…
1. How signals are transmitted by neuronsInhibitoryExcitatory
2. Molecular mechanism of chemical perturbation of neuron function
The story continues (next lecture) with signal transduction.
Kalyani
Learning OutcomesBy the end of the lesson, students will be able to:
-Draw the sequence of events during neuronal transmission
-Compare and contrast inhibitory and excitatory synapses
-Predict how receptor agonists and antagonists might interfere with neuron signal transmission
Kalyani
AssessmentFormative• Draw the sequence of events during neuron transmission• Predict – how receptor agonists and antagonists might interfere with
neuron signal transmission– the cumulative effect of multiple ligands for neuron receptors
Summative• Explain how excitation of an inhibitory pathway can lead
to change of function
Kalyani
Good afternoon
Trish
Trish
Sending messages to the brain
stimulus
output to brain
memory, coordinationbalance, pain, pleasure
Trish
The brain is made of billions of neurons
Joseph
Synapse
Presynaptic neuron
Postsynaptic neuron
Neurons form junctions called synapse and communicate by electrical signals Joseph
Synapse
Presynaptic neuron
Postsynaptic neuron
Neurotransmitter release
Joseph
Neural Transmission
Neurotransmitter
Synaptic cleft
Pre
Post
Joseph
Draw the sequence of events during neuron transmission
Joseph
Physiology of the Synapse
Voltage gated calcium channel
1
2
3
4
Neurotransmitter binding to ligand gated channels (receptors) 6
5 7
7
7
Action potential
Vesicles mobilization
Neurotransmitter release
Changes in the postsynaptic neuron
Breakdown of the neurotransmitter
Joseph
If neurotransmitter is inhibitory!
1
2
3
4
6
5 7
7
7
GABA release
Activity decreases in the postsynaptic neuron
If neurotransmitter is excitatory!
1
2
3
4
6
5 7
7
7
Glutamate release
Activity increases in the postsynaptic neuronJoseph
Xia
What happens after you drink alcohol?
? ?
Xia
Which image represents the effect of alcohol on the balance between inhibition and excitation?
A
B
CXia
Inhibition Excitation
Inhibition
Inhibition
Excitation
Excitation
Alcohol exposure enhances inhibition and decreases excitation
Xia
GABA
Glutamate
Miriam
Activity
GABA
Glutamate
How alcohol enhances inhibitory actions of GABA neurotransmission
Agonist
Jackie
(+)
How alcohol reduces the excitatory actions of glutamate neurotransmission
Alcohol
(-)
Antagonist
Jackie
Summative
Jackie
Alcohol + “downers” = ???
Xanax
Jackie
Thank You!!!