[Title]

Iroise DumontheilSam Gilbert

Sarah-Jayne Blakemore

Institute of Cognitive Neuroscience, UCL

UCL

Changes in recruitment of rostral prefrontal cortex during development

[Title]UCL

Match shape Match change

Smith, Keramatian & Christoff 2004

A, B, C, D, ?, ?, ?, ?, I , J, K

Switch - Stay

z = 4Gilbert et al. 2005, 2008

Increase with age in children (8-12 y.) Adults > Children

Crone et al. In press

Does the recruitment of lateral rostral PFC change during adolescence ?

[Title]UCL

Shapes task: (Smith, Keramatian & Christoff 2007)

- Factors: Relational or Control (shapes or texture)

- 20 blocks, alternating Control and Relational blocks

- 1s instruction, 32s block

- Relational blocks: 8 trials x 4s (max 3.5s + 0.5s blank)

- Control blocks: 10 trials x 3.2s (max 2.8s + 0.4s blank)

Subjects Females, right handed, adolescents: 18 x 11-16y, adults: 12 x 20-30y

ShapeTexture

Change

Alphabet task: (Gilbert and colleagues)

- Factors: Block type: SO/SI, Trial type: Switch/Stay/Other

- Duration of the SO/SI block varying from 3 to 20 seconds, average ~7seconds

- Self-paced

- 4 blocks of ~2min with short breaks in between / run

Y, Z, A, B, C, D, E, F, G, M, Z, F, X, T , E, A, O, P, Q, R, S, T

SO SOSI SI

Switch Switch SwitchStay Stay Stay

[Title]

[Investigators & Affiliations]

UCL Females, right handed

Adolescents: 18 x 11-16y, adults: 12 x 20-30y Three functional runs: Shapes - 11min, Alphabet – 2 x 8min

Structural: Joe’s Flash sequence – 2 x 6min Shapes: Blocked

Alphabet: Mixed design (SO/SI blocks, switch/stay events) Shapes analysis : Relational vs Control x Age

Alphabet analysis : SI vs SO x Age, Switch vs Stay x Age

Brain coverage: 30 slices, TR=3s , TE=50ms , 3x3x3mm