to fight cancer new living drug f.d.a. panel urges · ácio lula da silva, was found guilty of...

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U(D54G1D)y+$!;![!#!_ A Food and Drug Administra- tion panel opened a new era in medicine on Wednesday, unani- mously recommending that the agency approve the first-ever treatment that genetically alters a patient’s own cells to fight cancer, transforming them into what sci- entists call “a living drug” that powerfully bolsters the immune system to shut down the disease. If the F.D.A. accepts the recom- mendation, which is likely, the treatment will be the first gene therapy ever to reach the market. Others are expected: Re- searchers and drug companies have been engaged in intense competition for decades to reach this milestone. Novartis is now poised to be the first. Its treatment is for a type of leukemia, and it is working on similar types of treat- ments in hundreds of patients for another form of the disease, as well as multiple myeloma and an aggressive brain tumor. To use the technique, a separate treatment must be created for each patient — their cells re- moved at an approved medical center, frozen, shipped to a Novar- tis plant for thawing and process- ing, frozen again and shipped back to the treatment center. A single dose of the resulting product has brought long remis- sions, and possibly cures, to scores of patients in studies who were facing death because every other treatment had failed. The panel recommended approving the treatment for B-cell acute lym- phoblastic leukemia that has re- sisted treatment, or relapsed, in children and young adults aged 3 to 25. One of those patients, Emily Whitehead, now 12 and the first child ever given the altered cells, was at the meeting of the panel with her parents to advocate for approval of the drug that saved her life. In 2012, as a 6-year-old, she was treated in a study at the F.D.A. PANEL URGES NEW ‘LIVING DRUG’ TO FIGHT CANCER MILESTONE IN MEDICINE Treatment That Alters a Patient’s Own Cells to Fight Back By DENISE GRADY Continued on Page A13 RIO DE JANEIRO — The for- mer president of Brazil, Luiz In- ácio Lula da Silva, was found guilty of corruption and money laundering on Wednesday and sentenced to nearly 10 years in prison, a stunning setback for a politician who has wielded enor- mous influence across Latin America for decades. The case against Mr. da Silva, who raised Brazil’s profile on the world stage as president from 2003 to 2010, stemmed from charges that he and his wife ille- gally received about $1.1 million in improvements and expenses from a construction company for a beachfront apartment. In exchange, prosecutors said, the company was able to obtain lu- crative contracts from Petrobras, the state-controlled oil giant. His conviction tarnishes the legacy of one of Brazil’s most com- manding political figures, a char- ismatic leader who grew up poor, challenged the military dictator- ship and nurtured global ambi- tions for his nation, helping to land Ex-President Of Brazil Gets Years in Prison By ERNESTO LONDOÑO Continued on Page A8 LUCKNOW, India — A Hindu warrior-priest has been chosen to rule India’s most populous state, and the cable news channels can- not get enough of him. Yogi, as ev- eryone calls him, is so ascetic and incorruptible that he doesn’t use air-conditioners, they say. Yogi sleeps on a hard mattress on the floor. Yogi sometimes eats only an apple for dinner. But the taproot of Yogi Adityanath’s popularity is in a more ominous place. As leader of a temple known for its militant Hindu supremacist tradition, he built an army of youths intent on avenging historic wrongs by Mus- lims, whom he has called “a crop of two-legged animals that has to be stopped.” At one rally he cried out, “We are all preparing for reli- gious war!” Adityanath (pronounced Ah- DIT-ya-nath) was an astonishing choice by Narendra Modi, India’s prime minister, who came into of- fice three years ago promising to usher India into a new age of de- velopment and economic growth, and playing down any far-right Hindu agenda. But a populist drive to transform India into a “Hindu nation” has drowned out Mr. Modi’s development agenda, shrinking the economic and social space for the country’s 170 million Muslims. Few decisions in Indian politics matter more than the selection of the chief minister of Uttar Pradesh, because the post is seen as a springboard for future prime ministers. At the age of 45, the di- minutive, baby-faced Adityanath is receiving the kind of career- making attention that projects an Indian politician toward higher of- fice. “He is automatically on any- body’s list as a potential contend- er to succeed Modi,” said Sadanand Dhume, an India spe- cialist at the American Enterprise Institute. “They have normalized someone who, three years ago, was considered too extreme to be minister of state for textiles. Ev- erything has been normalized so quickly.” Adityanath did not respond to repeated requests for comment Anti-Muslim Venom Fuels Rise to Power in India By ELLEN BARRY and SUHASINI RAJ Yogi Adityanath is chief minister of India’s most-populous state. JITENDRA PRAKASH/REUTERS Continued on Page A10 WASHINGTON — The letters have come in to her office by the hundreds, heartfelt missives from college students, mostly men, who had been accused of rape or sexu- al assault. Some had lost schol- arships. Some had been expelled. A mother stumbled upon her son trying to take his own life, recalled Candice E. Jackson, the top civil rights official at the Department of Education. “Listening to her talk about walking in and finding him in the middle of trying to kill himself be- cause his life and his future were gone, and he was forever branded a rapist — that’s haunting,” said Ms. Jackson, describing a meeting with the mother of a young man who had been accused of sexual assault three months after his first sexual encounter. The young man, who main- tained he was innocent, had hoped to become a doctor. In recent years, on campus af- ter campus, from the University of Virginia to Columbia University, from Duke to Stanford, higher ed- ucation has been roiled by high- profile cases of sexual assault ac- cusations. Now Education Secre- tary Betsy DeVos is stepping into that maelstrom. On Thursday, she will meet in private with women who say they were assaulted, ac- cused students and their families, advocates for both sides and higher education officials, the first step in a contentious effort to re- examine policies of President Barack Obama, who made expan- sive use of his powers to investi- gate the way universities and col- leges handle sexual violence. How university and college ad- ministrations have dealt with campus sexual misconduct charges has become one of the most volatile issues in higher edu- cation, with many women saying higher education leaders have not taken their trauma seriously. But the Obama administration’s re- sponse sparked a backlash, not just from the accused and their families but from well-regarded law school professors who say new rules went too far. In an interview previewing her plans, Ms. Jackson, who heads the Education Department’s Office for Civil Rights and organized Thursday’s sessions, made clear A Review of Campus Rape Policy After Complaints by the Accused By ERICA L. GREEN and SHERYL GAY STOLBERG Continued on Page A18 A chunk of floating ice roughly the size of Delaware broke away from the Antarctic Peninsula this week, NASA confirmed on Wednesday, producing one of the largest icebergs ever recorded and providing a glimpse of how the Antarctic ice sheet might ulti- mately start to fall apart. A crack more than 120 miles long had developed over several years in a floating ice shelf called Larsen C. Scientists carefully tracked it in recent months, and images shot by a NASA satellite on Wednesday morning showed that a 2,200-square-mile chunk had finally broken loose. There is no scientific consensus over whether global warming is to blame. But the event fundamen- tally changes the landscape of the Antarctic Peninsula, according to Project Midas, a research team from Swansea University and Ab- erystwyth University in Wales that had been monitoring the rift since 2014. “The remaining shelf will be at its smallest ever known size,” said Adrian Luckman, a lead re- searcher for Project Midas. “This is a big change. Maps will need to be redrawn.” Larsen C, like two smaller ice shelves that collapsed before it, was holding back relatively little land ice, and it is not expected to contribute much to the rise of the sea. But in other parts of Antarctica, similar shelves are holding back enormous amounts of ice, and scientists fear that their future collapse could dump enough ice into the ocean to raise the sea level by many feet. How fast this could happen is unclear. In the late 20th century, the Ant- arctic Peninsula, which juts out from the main body of Antarctica and points toward South America, was one of the fastest-warming places in the world. That warming had slowed or perhaps reversed slightly in the 21st century, but sci- entists believe the ice is still catch- ing up to the higher temperatures. Some climate scientists believe the warming in the region was at least in part a consequence of hu- man-caused climate change, while others have disputed that, seeing a large role for natural vari- Antarctica Sheds Huge Iceberg That Hints at Future Calamity By JUSTIN GILLIS and JUGAL K. PATEL The Larsen C ice shelf on the Antarctic Peninsula in February. NASA says a chunk of ice broke away this week, producing one of the largest icebergs ever recorded. BRITISH ANTARCTIC SURVEY, VIA ASSOCIATED PRESS Continued on Page A6 DEFLATED A shorter recess is an admission of failure by the Sen- ate, Carl Hulse writes. PAGE A17 DELUDED Using email is foolish, but it leaves a marvelous record, Farhad Manjoo writes. PAGE B1 DEFIANT The nominee to lead the F.B.I. said he would stand up to the president. PAGE A16 Some parents believe the departure of the principal at Fieldston Lower was not completely voluntary. PAGE A21 Anger Over a Swift Retirement David Wildstein, who schemed to block traffic lanes near the George Washing- ton Bridge, will not go to jail. PAGE A19 NEW YORK A19-21 Probation in Bridge Scandal Scientists can store video on DNA, retrieving it after generations of growth, and hope someday to use the process to record cell behavior. PAGE A11 NATIONAL A11-18 Living Cell Used as Hard Drive The military plane that crashed Mon- day, killing 16 people, spread debris across a mile of farmland. PAGE A13 Emergency at High Altitude France’s leader, Emmanuel Macron, has positioned himself as President Trump’s first point of contact in Europe. PAGE A8 INTERNATIONAL A4-10 France Softens Toward Trump Warren LeGarie and Albert Hall have turned the Las Vegas summer league into a booming business. PAGE B11 An N.B.A. Summer Franchise Andy Murray, above, lost in five sets to Sam Querrey, while Novak Djokovic left his match with an elbow injury. PAGE B11 SPORTSTHURSDAY B11-14 Big Names Exit Wimbledon “Flash organizations,” modeled on filmmaking, are finding their way into more industries, assembling freelancers and then disbanding. PAGE B1 BUSINESS DAY B1-10 Gone in a Flash Monica Hesse’s “American Fire” is a twisting story with all the elements of a lively crime procedural. PAGE C1 ARTS C1-8 Baffling Tale of an Arsonist At New York Fashion Week: Men’s, the Belgian designer Raf Simons put on a steamy nighttime show at a market under the Manhattan Bridge. PAGE D1 THURSDAY STYLES D1-8 Hometown Edge to Fashion Gary Cohn and H.R. McMaster PAGE A23 EDITORIAL, OP-ED A22-23 THE FAMILY The Trump siblings Ivanka, Eric and Donald Jr. are caught in a storm-tossed presidency, and it’s personal for their father. PAGE A14 TASOS KATOPODIS/AGENCE FRANCE-PRESSE — GETTY IMAGES WASHINGTON — At 6:14 p.m. on June 7, 2016, Donald Trump Jr. clicked the send button on an email to confirm a meeting with a woman described as a “Russian government attorney” who would give him “information that would incriminate Hillary and her deal- ings with Russia.” Three hours later, his father, Donald J. Trump, claimed victory in the final primary races propel- ling him to the Republican presi- dential nomination and a general election contest against former Secretary of State Hillary Clinton. In his victory speech, Mr. Trump promised to deliver a major ad- dress detailing Mrs. Clinton’s “corrupt dealings” to give “favor- able treatment” to foreign govern- ments, including “the Russians.” The White House said the tim- ing was a coincidence. The young- er Mr. Trump said this week that he never told his father about the meeting with the Russian lawyer, and the president said on Wednes- day that he did not know about it until a few days ago. But the time frame raised questions that inves- tigators will presumably examine as they try to piece together who knew what, and when, last year during what American intelli- gence agencies have called a Rus- sian effort to influence the presi- dential election. The meeting with the Russian lawyer came at a crucial stage in the elder Mr. Trump’s against-the- odds campaign as he pivoted to- Meeting Renews Scrutiny on Trump’s ’16 Actions By PETER BAKER Continued on Page A14 Late Edition VOL. CLXVI . . . No. 57,657 © 2017 The New York Times Company NEW YORK, THURSDAY, JULY 13, 2017 Today, sunshine, afternoon showers, hot, humid, high 93. Tonight, humid, showers, thunderstorms, low 72. To- morrow, cooler, showers, high 76. Weather map appears on Page B9. $2.50

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Page 1: TO FIGHT CANCER NEW LIVING DRUG F.D.A. PANEL URGES · ácio Lula da Silva, was found guilty of corruption and money laundering on Wednesday and sentenced to nearly 10 years in prison,

C M Y K Nxxx,2017-07-13,A,001,Bs-4C,E2

U(D54G1D)y+$!;![!#!_

A Food and Drug Administra-tion panel opened a new era inmedicine on Wednesday, unani-mously recommending that theagency approve the first-evertreatment that genetically alters apatient’s own cells to fight cancer,transforming them into what sci-entists call “a living drug” thatpowerfully bolsters the immunesystem to shut down the disease.

If the F.D.A. accepts the recom-mendation, which is likely, thetreatment will be the first genetherapy ever to reach the market.Others are expected: Re-searchers and drug companieshave been engaged in intensecompetition for decades to reachthis milestone. Novartis is nowpoised to be the first. Its treatmentis for a type of leukemia, and it isworking on similar types of treat-ments in hundreds of patients foranother form of the disease, aswell as multiple myeloma and anaggressive brain tumor.

To use the technique, a separatetreatment must be created foreach patient — their cells re-moved at an approved medicalcenter, frozen, shipped to a Novar-tis plant for thawing and process-ing, frozen again and shippedback to the treatment center.

A single dose of the resultingproduct has brought long remis-sions, and possibly cures, toscores of patients in studies whowere facing death because everyother treatment had failed. Thepanel recommended approvingthe treatment for B-cell acute lym-phoblastic leukemia that has re-sisted treatment, or relapsed, inchildren and young adults aged 3to 25.

One of those patients, EmilyWhitehead, now 12 and the firstchild ever given the altered cells,was at the meeting of the panelwith her parents to advocate forapproval of the drug that savedher life. In 2012, as a 6-year-old,she was treated in a study at the

F.D.A. PANEL URGESNEW ‘LIVING DRUG’TO FIGHT CANCER

MILESTONE IN MEDICINE

Treatment That Alters aPatient’s Own Cells

to Fight Back

By DENISE GRADY

Continued on Page A13

RIO DE JANEIRO — The for-mer president of Brazil, Luiz In-ácio Lula da Silva, was foundguilty of corruption and moneylaundering on Wednesday andsentenced to nearly 10 years inprison, a stunning setback for apolitician who has wielded enor-mous influence across LatinAmerica for decades.

The case against Mr. da Silva,who raised Brazil’s profile on theworld stage as president from2003 to 2010, stemmed fromcharges that he and his wife ille-gally received about $1.1 million inimprovements and expenses froma construction company for abeachfront apartment.

In exchange, prosecutors said,the company was able to obtain lu-crative contracts from Petrobras,the state-controlled oil giant.

His conviction tarnishes thelegacy of one of Brazil’s most com-manding political figures, a char-ismatic leader who grew up poor,challenged the military dictator-ship and nurtured global ambi-tions for his nation, helping to land

Ex-President Of Brazil GetsYears in PrisonBy ERNESTO LONDOÑO

Continued on Page A8

LUCKNOW, India — A Hinduwarrior-priest has been chosen torule India’s most populous state,and the cable news channels can-not get enough of him. Yogi, as ev-eryone calls him, is so ascetic andincorruptible that he doesn’t useair-conditioners, they say. Yogisleeps on a hard mattress on thefloor. Yogi sometimes eats only anapple for dinner.

But the taproot of YogiAdityanath’s popularity is in amore ominous place. As leader ofa temple known for its militantHindu supremacist tradition, hebuilt an army of youths intent onavenging historic wrongs by Mus-lims, whom he has called “a cropof two-legged animals that has tobe stopped.” At one rally he criedout, “We are all preparing for reli-gious war!”

Adityanath (pronounced Ah-DIT-ya-nath) was an astonishingchoice by Narendra Modi, India’sprime minister, who came into of-fice three years ago promising tousher India into a new age of de-velopment and economic growth,and playing down any far-rightHindu agenda. But a populistdrive to transform India into a“Hindu nation” has drowned outMr. Modi’s development agenda,

shrinking the economic and socialspace for the country’s 170 millionMuslims.

Few decisions in Indian politicsmatter more than the selection ofthe chief minister of UttarPradesh, because the post is seenas a springboard for future primeministers. At the age of 45, the di-minutive, baby-faced Adityanathis receiving the kind of career-making attention that projects anIndian politician toward higher of-fice.

“He is automatically on any-body’s list as a potential contend-er to succeed Modi,” saidSadanand Dhume, an India spe-cialist at the American EnterpriseInstitute. “They have normalizedsomeone who, three years ago,was considered too extreme to beminister of state for textiles. Ev-erything has been normalized soquickly.”

Adityanath did not respond torepeated requests for comment

Anti-Muslim Venom Fuels Rise to Power in India By ELLEN BARRY

and SUHASINI RAJ

Yogi Adityanath is chief minister of India’s most-populous state.JITENDRA PRAKASH/REUTERS

Continued on Page A10

WASHINGTON — The lettershave come in to her office by thehundreds, heartfelt missives fromcollege students, mostly men, whohad been accused of rape or sexu-al assault. Some had lost schol-arships. Some had been expelled.A mother stumbled upon her sontrying to take his own life, recalledCandice E. Jackson, the top civilrights official at the Departmentof Education.

“Listening to her talk aboutwalking in and finding him in themiddle of trying to kill himself be-cause his life and his future weregone, and he was forever brandeda rapist — that’s haunting,” saidMs. Jackson, describing a meetingwith the mother of a young manwho had been accused of sexualassault three months after his firstsexual encounter.

The young man, who main-tained he was innocent, had hopedto become a doctor.

In recent years, on campus af-ter campus, from the University ofVirginia to Columbia University,from Duke to Stanford, higher ed-ucation has been roiled by high-profile cases of sexual assault ac-cusations. Now Education Secre-

tary Betsy DeVos is stepping intothat maelstrom. On Thursday, shewill meet in private with womenwho say they were assaulted, ac-cused students and their families,advocates for both sides andhigher education officials, the firststep in a contentious effort to re-examine policies of PresidentBarack Obama, who made expan-sive use of his powers to investi-gate the way universities and col-leges handle sexual violence.

How university and college ad-ministrations have dealt withcampus sexual misconductcharges has become one of themost volatile issues in higher edu-cation, with many women sayinghigher education leaders have nottaken their trauma seriously. Butthe Obama administration’s re-sponse sparked a backlash, notjust from the accused and theirfamilies but from well-regardedlaw school professors who saynew rules went too far.

In an interview previewing herplans, Ms. Jackson, who heads theEducation Department’s Officefor Civil Rights and organizedThursday’s sessions, made clear

A Review of Campus Rape PolicyAfter Complaints by the Accused

By ERICA L. GREEN and SHERYL GAY STOLBERG

Continued on Page A18

A chunk of floating ice roughlythe size of Delaware broke awayfrom the Antarctic Peninsula thisweek, NASA confirmed onWednesday, producing one of thelargest icebergs ever recordedand providing a glimpse of howthe Antarctic ice sheet might ulti-mately start to fall apart.

A crack more than 120 mileslong had developed over severalyears in a floating ice shelf calledLarsen C. Scientists carefullytracked it in recent months, andimages shot by a NASA satelliteon Wednesday morning showedthat a 2,200-square-mile chunkhad finally broken loose.

There is no scientific consensusover whether global warming is toblame. But the event fundamen-tally changes the landscape of theAntarctic Peninsula, according toProject Midas, a research teamfrom Swansea University and Ab-erystwyth University in Walesthat had been monitoring the riftsince 2014.

“The remaining shelf will be atits smallest ever known size,” saidAdrian Luckman, a lead re-searcher for Project Midas. “This

is a big change. Maps will need tobe redrawn.”

Larsen C, like two smaller iceshelves that collapsed before it,was holding back relatively littleland ice, and it is not expected tocontribute much to the rise of thesea. But in other parts ofAntarctica, similar shelves areholding back enormous amountsof ice, and scientists fear that theirfuture collapse could dumpenough ice into the ocean to raisethe sea level by many feet. Howfast this could happen is unclear.

In the late 20th century, the Ant-arctic Peninsula, which juts outfrom the main body of Antarcticaand points toward South America,was one of the fastest-warmingplaces in the world. That warminghad slowed or perhaps reversedslightly in the 21st century, but sci-entists believe the ice is still catch-ing up to the higher temperatures.

Some climate scientists believethe warming in the region was atleast in part a consequence of hu-man-caused climate change,while others have disputed that,seeing a large role for natural vari-

Antarctica Sheds Huge IcebergThat Hints at Future Calamity

By JUSTIN GILLIS and JUGAL K. PATEL

The Larsen C ice shelf on the Antarctic Peninsula in February. NASA says a chunk of ice broke away this week, producing one of the largest icebergs ever recorded.BRITISH ANTARCTIC SURVEY, VIA ASSOCIATED PRESS

Continued on Page A6

DEFLATED A shorter recess is anadmission of failure by the Sen-ate, Carl Hulse writes. PAGE A17

DELUDED Using email is foolish,but it leaves a marvelous record,Farhad Manjoo writes. PAGE B1

DEFIANT The nominee to lead theF.B.I. said he would stand up tothe president. PAGE A16

Some parents believe the departure ofthe principal at Fieldston Lower wasnot completely voluntary. PAGE A21

Anger Over a Swift Retirement

David Wildstein, who schemed to blocktraffic lanes near the George Washing-ton Bridge, will not go to jail. PAGE A19

NEW YORK A19-21

Probation in Bridge Scandal

Scientists can store video on DNA,retrieving it after generations of growth,and hope someday to use the process torecord cell behavior. PAGE A11

NATIONAL A11-18

Living Cell Used as Hard Drive

The military plane that crashed Mon-day, killing 16 people, spread debrisacross a mile of farmland. PAGE A13

Emergency at High Altitude

France’s leader, Emmanuel Macron, haspositioned himself as President Trump’sfirst point of contact in Europe. PAGE A8

INTERNATIONAL A4-10

France Softens Toward TrumpWarren LeGarie and Albert Hall haveturned the Las Vegas summer leagueinto a booming business. PAGE B11

An N.B.A. Summer Franchise

Andy Murray, above, lost in five sets toSam Querrey, while Novak Djokovic lefthis match with an elbow injury. PAGE B11

SPORTSTHURSDAY B11-14

Big Names Exit Wimbledon

“Flash organizations,” modeled onfilmmaking, are finding their way intomore industries, assembling freelancersand then disbanding. PAGE B1

BUSINESS DAY B1-10

Gone in a Flash

Monica Hesse’s “American Fire” is atwisting story with all the elements of alively crime procedural. PAGE C1

ARTS C1-8

Baffling Tale of an ArsonistAt New York Fashion Week: Men’s, theBelgian designer Raf Simons put on asteamy nighttime show at a marketunder the Manhattan Bridge. PAGE D1

THURSDAY STYLES D1-8

Hometown Edge to Fashion

Gary Cohn and H.R. McMaster PAGE A23

EDITORIAL, OP-ED A22-23

THE FAMILY The Trump siblings Ivanka, Eric and Donald Jr. are caughtin a storm-tossed presidency, and it’s personal for their father. PAGE A14

TASOS KATOPODIS/AGENCE FRANCE-PRESSE — GETTY IMAGES

WASHINGTON — At 6:14 p.m.on June 7, 2016, Donald Trump Jr.clicked the send button on anemail to confirm a meeting with awoman described as a “Russiangovernment attorney” who wouldgive him “information that wouldincriminate Hillary and her deal-

ings with Russia.”Three hours later, his father,

Donald J. Trump, claimed victoryin the final primary races propel-ling him to the Republican presi-dential nomination and a generalelection contest against formerSecretary of State Hillary Clinton.In his victory speech, Mr. Trumppromised to deliver a major ad-dress detailing Mrs. Clinton’s

“corrupt dealings” to give “favor-able treatment” to foreign govern-ments, including “the Russians.”

The White House said the tim-ing was a coincidence. The young-er Mr. Trump said this week thathe never told his father about themeeting with the Russian lawyer,and the president said on Wednes-day that he did not know about ituntil a few days ago. But the timeframe raised questions that inves-tigators will presumably examineas they try to piece together whoknew what, and when, last yearduring what American intelli-gence agencies have called a Rus-sian effort to influence the presi-dential election.

The meeting with the Russianlawyer came at a crucial stage inthe elder Mr. Trump’s against-the-odds campaign as he pivoted to-

Meeting Renews Scrutiny on Trump’s ’16 Actions

By PETER BAKER

Continued on Page A14

Late Edition

VOL. CLXVI . . . No. 57,657 © 2017 The New York Times Company NEW YORK, THURSDAY, JULY 13, 2017

Today, sunshine, afternoon showers,hot, humid, high 93. Tonight, humid,showers, thunderstorms, low 72. To-morrow, cooler, showers, high 76.Weather map appears on Page B9.

$2.50