together — today — we have an extraordinary opportunity to...

Together — today — we have an extraordinary opportunity to transform childhood health

The Campaign for Seattle Children’s 1

Until we can say YES to every child and family, our work is far from done.Together — today — we have an extraordinary opportunity to transform childhood health for generations to come.

2 It Starts With YES


Right now, a worried mom or dad is on the way to Seattle Children’s with a sick child.

Can we give them hope? Can we provide the care their child needs? Do we have a cure?

We see a day when we can say yes to hope, care and cure every time, for every child. To get there, we need to continue to push, to innovate, to advocate, relentlessly.

We need to “go big.”

That’s why we’ve launched It Starts With Yes: The Campaign for Seattle Children’s. Our dollar goal is big, for sure, bold even — $1 billion bold.

Bigger and bolder yet is our vision: to transform children’s health.

We have the clinical expertise to get it done. We have the research capacity and the intellectual muscle. We have the plan, the people and the passion.

And we have you.

With your generous support, we will create healthier communities — in our region, across our nation and around the world. We will save promising young lives, for a lifetime of dreams and achievements. We will be there when kids need us most.

It Starts With YES.

Jeff Sperring, MDChief Executive OfficerSeattle Children’s

We live in a special time and place.

Medical breakthroughs that were unimaginable even a decade ago are now within reach.

So, too, is our continued promise to provide hope, care and cures for every child in need.

Can we deliver?

With your help, the answer is a resounding YES.



It Starts With YES is a remarkable convergence of purpose and vision, momentum and opportunity.Today, thanks to your support, Seattle Children’s continues to deliver on our founding promise to provide care for every family in need. We’re also on the cusp of transforming treatments and cures for some of the most devastating childhood diseases.

This convergence of purpose and vision, of momentum and opportunity, of world-class talent and seemingly unlimited possibilities positions us to dream like never before.

You can help us deliver on our biggest ideas — life-changing ideas that point toward an amazing future.

For us. For you. For kids.Every child deserves a childhood. With this campaign, and with your partnership, we are:

• Advancing our core mission to care for every child

• Delivering on the promise and power of immunotherapy

• Unlocking the mysteries of the childhood brain

• Launching a new era for community health and wellness

Life-Changing Idea:

Our founders had a clear mission when they opened the doors of the Children’s Orthopedic Hospital more than a century ago: to care for every child in need across our region, regardless of their family’s finances.

They also promised to be there for every child, regardless of race or religion.

Their far-reaching vision formed the foundation that has enabled what is now Seattle Children’s to thrive through world wars, great economic turmoil and periods of civil unrest.


Celebrating Our CommunityToday, we continue to be guided by the same enduring goals and values. Now, as it was back in 1907, it’s still all about the kids.

That’s why we continue to celebrate our community, people like you whose foresight and generosity have helped us meet the unique challenges of each generation of children.

Once again, without hesitation — but with heartfelt gratitude — we call on our friends, supporters and champions to help advance our core mission.

Say yes to the children who depend on us when they are sick, hurt and scared.

Advancing Our Core Mission to Care for Every Child

Can we care for every child who needs us — today, tomorrow and always?

Caleb, 6, has a serious, chronic condition for which there is no cure — a prognosis shared by many of our patients. Your investment improves quality of life at every age and developmental stage for medically complex kids like Caleb.

YES

“ My digestive system doesn’t work, but I can still play.”— Caleb, at age 6

Advancing our core mission ensures that illness doesn’t take away a childhood — and helps us envision a future without childhood disease.

Your generous gift will help:• Strengthen the clinical programs that bring

exceptional care to our patients, such ascardiology and heart surgery, diabetes andendocrinology, orthopedics and neonatology.This includes the opportunity to extend yourlegacy with an enduring gift that will keep SeattleChildren’s at the forefront of specialty care.

• Expand our facilities to increase our capacity tocare for patients and advance new discoveries.Continued investments in capital will propel ourmission far into the future.

• Carry out our founding promise to providemedical care to all children in our region regard-less of a family’s ability to pay. Unexpectedhospital costs hit many families hard, leading tomountains of medical bills that can be impossibleto pay. We typically provide roughly $120 millionor more a year to cover care for families in need.Your investment will benefit kids for decadesto come.

• Secure the flexible funding required to respondnimbly to emerging needs and opportunities,such as recruiting a world-class doctor or scien-tist or purchasing new, innovative equipmentto provide early diagnoses or novel treatments.With your support, we will shape the future ofpediatric health.


Thanks to you, we can meet the unique needs of each generation of kids.

Caleb’s Daily Journey

Our son Caleb, 6, was born with a rare and very

serious intestinal condition that will challenge

him — and all of us in the family — for the rest

of our lives.

I always say we hope for the best and prepare

for the worst on a daily basis.

Moving to Seattle to work with Seattle Children’s

intestinal failure team has given my smart boy

the active childhood he deserves — and made

our journey a little less unpredictable and a lot

less scary.

Life-Changing Idea:

Cancer immunotherapy is a groundbreaking approach that reprograms a child’s own T cells — the white blood cells that fight infections — to find and kill cancer cells.

Early clinical trials have shown promising results for patients who were not responding to standard therapies. In our first study of 42 patients with acute lymphoblastic leukemia (the most common cancer in children), 93% achieved initial remission.

These are kids who had relapsed more than once and were out of traditional treatment options. Each was on the verge of hospice care. Now we can begin to imagine a future with no surgery, no radiation, no chemo — and no debilitating side effects that rob so many kids of a healthy future.


Remarkable PotentialWe’re in the early stages of fully harnessing the promise and potential of T cells. Many hurdles remain. Nearly half of the patients from our first clinical trial relapsed. But make no mistake: The potential is remarkable.

We are determined to redouble our efforts. To that end, we launched Strong Against Cancer, a national fundraising initiative that supports cancer immunotherapy research and our quest to bring cures to all kids with cancer.

The success of immunotherapy has implications for curing disease at the cellular level as well. With your help, we will speed up research for dozens of other childhood diseases — from diabetes to sickle cell to HIV.

Say yes to a miracle in the making.

Delivering on the Promise and Power of Immunotherapy

YES

Can we use her own immune system to cure her cancer?

When Sarah and Antony Cross got on a plane from England with their daughter, they felt a mix of emotions — hope, fear and determination. Erin received T-cell immunotherapy and then they waited. A few weeks later, they learned the treatment worked.

“ For us, that infusion — that one moment — meant everything. The one moment that could give us our little girl back.”

— Sarah Cross, Erin’s mom

Philanthropy has fueled rapid advances in T-cell therapy. Now you can help us turn a promising possibility into a life-saving cure.

Your generous gift will help:• Increase access to clinical trials and patient care

for kids who are out of options. Our plans call forexpanding the number of T-cell immunotherapyclinical trials we can conduct at any one time.That way, kids with cancer — for whom time isof the essence — will not have to wait months fora trial to open. We will also expand outpatientcancer care facilities on our main campus tobetter serve patients and their families.

• Recruit star clinical and research talent andexpand program areas at the Ben Towne Centerfor Childhood Cancer Research. Investing in thebest and the brightest — in the lab and at thebedside — gives our patients and families theirbest chance to beat cancer and other diseases.With your support, we will continue to recruitand retain the top physicians and scientists fromaround the world to stop cancer in its tracks.

• Construct Building Cure, the research facilitythat will revolutionize the way childhood diseasesare treated. Cell therapies hold the promise ofcuring many diseases at the cellular level. Justtreating symptoms is not the answer; now wehave the opportunity to fix the causes of manyillnesses. With your help, we will make majorinvestments to speed up research for dozensof childhood diseases, from diabetes to sicklecell disease to HIV.

• Expand our ability to manufacture cell therapyproducts, such as T cells. It’s a costly proposition,yet it is quickly emerging as the future of treat-ment for cancer and genetic diseases. When ourCure Factory (two stories within Building Cure) isup and running, we will be able to produce enoughcell therapy products to help 1,000 children eachyear versus the 150 we can help today.


With your support, we can imagine a future without pediatric cancer.

Cancer Warrior

For Dr. Mike Jensen,

immunotherapy’s a family tradition:

Jensen’s grandfather was a Danish

vaccine pioneer. Jensen’s team

is achieving remarkable results

in clinical trials that harness kids’

own immune systems to beat

leukemia. Jensen’s expertise

is grounded in decades of

immunotherapy research.

Life-Changing Idea:

Children and teens are not small adults. Their growing bodies are complex and always changing; marvelously resilient in some ways, breathtakingly fragile in others.

Perhaps nowhere are these differences between kids and adults more pronounced than with the brain. And Seattle Children’s is at the forefront of understanding the mechanisms of the developing childhood brain.

A Profound Moment in TimeNeuroscience specialists at Seattle Children’s collaborate across disciplines to study the brain at every level. Their clinical and research work is leading to earlier diagnoses and groundbreaking therapies to treat a wide range of brain disorders — such as epilepsy, autism, brain tumors, ADHD and other mental and behavioral health issues.


Potential cures for some of these neurological diseases are on the horizon, thanks to the ground-work our specialists have set in place and the unsurpassed expertise and passion they bring to this emerging field.

Dramatic advances in precision medicine, person-alized for each child, point to a future in which we can use a child’s unique genetic or molecular profile to effectively diagnose and treat brain disorders.

It adds up to a profound moment in time — a once-in-a-generation opportunity — in which we can more readily target the cause of the disease, not just treat the symptoms.

Say yes to a brighter future for our patients and millions like them around the globe.

Unlocking the Mysteries of the Developing Brain

YES

Can we find better ways to treat her neurological disorder?

When Carmen was diagnosed with epilepsy as a preschooler, her parents entrusted a team at Seattle Children’s to remove a portion of her brain, hoping she would no longer suffer from debilitating seizures. In 2017, she graduated from high school as valedictorian and started college.

“ I am really excited to get this surgery. I have a lot of important things to do!” — Carmen Conforti, at age 4


Our donors have helped hasten lifesaving treatments for brain disorders.

Aiming for Obsolescence

Brain surgeon Dr. Jeff Ojemann envisions

a future in which he’s obsolete — a future

of personalized, precision medicine that

can cure epilepsy and destroy brain tumors

without surgery. Meanwhile, he uses break-

throughs in guided imaging and fiber-optic

lasers to make surgery far less invasive and

far more precise.

Breathing New Ideas Into Research

Dr. Nino Ramirez, director of the Center for

Integrative Brain Research, seeks to find

breakthrough treatments for many diseases

and challenges, including epilepsy, autism,

tumors and cognitive disorders. His early

research — unraveling the neural networks

behind breathing, thinking and sleeping —

is paving the way to better understand and

potentially cure childhood diseases.

Now you can help us develop precision approaches that target the underlying cause of a child’s neuro-logical difference.

Your generous gift will help:• Expand and fully integrate clinical programs

and research studies to transform treatments and quicken the pace to find cures for kids with a wide range of brain disorders. Experts at Seattle Children’s work across disciplines, translating research results into real-life solutions as quickly as possible. You can help advance these efforts at the bedside, at the nationally recognized Seattle Children’s Research Institute and at our Center for Integrative Brain Research, in collaboration with the University of Washington.

• Recruit, train and retain a renowned team of experts — including physicians, surgeons, scien-tists and psychologists — all working towards a common goal: to advance innovative therapies and cures that improve the lives of children and families worldwide. These strategic investments will build on our strengths as a leading center for treating brain disorders, help attract world-class talent and keep us at the forefront of innovation, now and into the future.

• Expand vital facilities and infrastructure and create a national data bank to support clinical and research excellence. Investing in a state-of-the-art neurosciences center will ensure that we deliver the best care and outcomes possible for all children. Investments in technology will revolutionize our understanding and treatment of brain disorders as we build better predictive models for individual patients. Big data is the big idea as we create a massive national database to allow us to identify patterns in brain disorders and apply what we learn to make more precise, personalized treatment choices for kids.

Life-Changing Idea:

We make every effort to give sick kids the extraor-dinary care they need and deserve. But that’s not enough. We also must do whatever it takes to keep more children from ever needing to come to a hospital. That’s why the Odessa Brown Children’s Clinic (OBCC) is central to our mission.

OBCC has been a beacon of hope in our city for nearly 50 years. The clinic manages over 40,000 patient visits a year, offering medical, dental and mental health services — especially to families in low-income communities.

Big-Picture ViewOBCC’s big-picture view takes us beyond the clinic and into the heart of our community. That can mean helping a child stay in school. Or making sure a family’s home is mold-free. Or providing a child with warm outerwear during the winter months.


Or helping families provide adequate food and nutrition for their children.

The demand for services is on the rise. How will we respond? By doing something bold. Something different. Something unprecedented.

We will create a new model for OBCC, one in which addressing the social, economic and environmental roots of illness is as important as direct medical care.The new OBCC will give us a unique opportunity to care for more kids, to keep them on the path toward successful futures — and to model kindness and inclusivity to our patients, their families and our community. What better investment is there?

Say yes to creating the healthiest generation of kids ever.

Launching a New Era for Community Health and Wellness

YES

Can we give them a fighting chance to stay healthy?

Jonah and Jeremiah turn to their grandma and guardian, Marva Harris, for just about everything. Marva turns to OBCC — and physicians like Dr. Shaquita Bell — as the one place where her boys can receive the comprehensive and compassionate care they need.

“ Jonah and Jeremiah’s doctors take the time to find out what’s going on in their lives, not just their bodies.” — Marva Harris, proud grandma

Philanthropy has kept Odessa Brown at the forefront of delivering equitable health to Seattle’s children. Support for It Starts With Yes will help clear the obstacles that impede the health and development of youth from disadvantaged backgrounds.

Your generous gift will help:• Build a new Odessa Brown Children’s Clinic.

OBCC, based in Seattle’s Central District, is our only primary care clinic. It has been at the forefront of delivering equitable health and wellness care to low-income and ethnically diverse children for nearly half a century. Your support will help us build a larger location to serve more kids and for the many low-income families who have moved to South Seattle, South King County and beyond due to the rising cost of housing in Seattle’s urban core.

• Create partnerships that matter. We will expand the number and variety of partnerships we have with social service organizations whose expertise complements our own. These alliances — which will likely include organizations with expertise in areas such as food security, foster care, active living, vocational services, housing and transportation — will enable us to better address the social, economic and environmental factors that determine a child’s well-being.

• Develop a community health innovation hub. Your investment will also allow us to set up a one-of-a-kind proving ground at the new clinic where clinicians, researchers and families work together to develop and test strategies that counteract the greatest challenges to children’s health. This will include an emphasis on maternal health and nutrition, knowing that a healthy child needs a healthy mother. We’ll share the most successful strategies with other communities in our region and beyond.


We need you to help us keep Seattle’s kids healthy today … and tomorrow.

An Expansive Vision of Community Health

After two decades as medical

director of the Odessa Brown

Children’s Clinic, Ben Danielson, MD,

is as passionate as ever about the

clinic’s mission — and is thrilled

about plans to build a new clinic

in South Seattle. “The community

spoke, and we listened,” he says.

At a time when many hospitals are cutting back, we ask you to join us as we seize the moment and do more.

We don’t believe today’s volatile healthcare landscape is a reason to scale back services at the expense of children who need us now more than ever.

With your help, Seattle Children’s will continue to invest in the people, programs and facilities that bring hope, care and cures to kids and families.



Join us and say YES.The talent, the will and the passion are here.

The vision is in place. The opportunity is before us.

The time is now.

Together, we can transform children’s health for generations to come.

It Starts With YES.


Total Campaign Goal: $1 Billion

It Starts With YES — The Campaign at a Glance

Advancing Our Core Mission to

Care for Every Child

Delivering on the Power and Promise of Immunotherapy

Unlocking the Mysteries of the Developing Brain

Launching a New Era for Community Health

and Wellness

Ensuring families can count on us today and always through legacy gifts

This is our moment to raise our collective voices and shout out YES.

YES … to eliminating barriers to quality healthcare for all kids.

YES … to new research trials, new facilities — and new discoveries.

YES … to ensuring families can count on us, now and always.

YES … to a generous, far-reaching gift to transform children’s health.



Our MissionWe provide hope, care and cures to help every child live the healthiest and most fulfilling life possible.

Our VisionSeattle Children’s will be an innovative leader in pediatric health and wellness through our unsurpassed quality, clinical care, relentless spirit of inquiry and compassion for children and their families.

Our ValuesCompassion

Excellence

Integrity

Collaboration

Equity

Innovation

Seattle Children’s Hospital and Research Foundation6901 Sand Point Way NESeattle, WA 98115TEL 206-987-2153

www.seattlechildrens.org

© 2017 Seattle Children’s, Seattle, Washington. All rights reserved.

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