ADDICTION

The Cleveland Clinic Foundation (Cleveland Clinic)Fighting opioid addiction through education and multidisciplinary approaches to pain managementWebsite: my.clevelandclinic.orgOverview video: https://youtu.be/bkdOH2HC_xM

Facing AddictionRecognizing addiction as a chronic disease and fighting it with diagnosis, treatment, and supportWebsite: https://www.facingaddiction.orgOverview video: https://youtu.be/6VDL-CypaxQ

West Virginia University Research CorporationReversing a trend towards increasing mortality in West Virginia through opioid addiction treatment, job training, and community engagementWebsite: hr.research.wvu.eduOverview video: https://youtu.be/rKmYohDh7wY

AFFORDABLE AND CLEAN ENERGY

Global Alliance for Clean Cookstoves, an initiative of the United Nations FoundationReducing indoor pollution through increased supply of clean cookstoves in Uganda and KenyaWebsite: http://www.unfoundation.org/what-we-do/campaigns-and-initiatives/cookstoves/Overview video: https://youtu.be/rT7_CEGuvrw

Nova Lumos Netherlands Holding B.V.Distributing affordable solar systems in NigeriaWebsite: http://www.nova-lumos.comOverview video: https://youtu.be/bq-a0Xj6aI8

The Solutions ProjectWorking to transition to a 100 percent clean, renewable energy economy through evidence building and community engagementWebsite: thesolutionsproject.orgOverview video: https://youtu.be/hJLwKbgPtIU

The University of New South WalesAccelerating development and deployment of photovoltaics to increase reliance on solar energy and reduce CO2 emissionsWebsite: https://www.unsw.edu.auOverview video: https://youtu.be/IgqDUnB0zfw

University of WaterlooAddressing energy poverty by supporting innovators on distributed generation and energy storageWebsite: https://uwaterloo.caOverview video: https://youtu.be/lnvtfLiV5DI

We Care SolarReducing maternal and newborn mortality through deployment of a compact solar-power unit for medical lightingWebsite: https://wecaresolar.orgOverview video: https://youtu.be/0DgzyMxicDA

TOP 200 APPLICANTS

John D. and Catherine T. MacArthur Foundation April 2017

www.100andchange.org/#results/top200 • #100andChange

100&Change is a MacArthur Foundation competition for a $100 million grant to fund a single proposal that promises real and measurable progress in solving a critical problem of our time.

100&CHANGE TOP 200 APPLICANTS

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ANTIBIOTIC RESISTANCE

Board of Trustees of the University of IllinoisFinding new antibiotics to combat “superbugs” by mining the genes of natural microbesWebsite: www.bot.uillinois.eduOverview video: https://youtu.be/iIrGUi95ko4

Northeastern UniversityDiscovering new antibiotics from microbes in soilWebsite: https://www.northeastern.eduOverview video: https://youtu.be/drXfuvqY_oA

UC RegentsCombating antibiotic resistance through global tracking of infectious disease cases and effective treatmentsWebsite: https://twin-cities.umn.eduOverview video: https://youtu.be/quT7XHGez4Y

The University of MelbourneEliminating over-use of antibiotics in human and animal medicineWebsite: www.unimelb.edu.auOverview video: https://youtu.be/G5jL_J4fsPc

ARTS AND CULTURE

University of Southern CaliforniaTraining cultural heritage scholars in digital preservation techniquesWebsite: www.usc.eduOverview video: https://youtu.be/l0T72JdhJ0s

ASSISTIVE TECHNOLOGY

Beneficent Technology, Inc. DBA BenetechProviding accessible books to people with disabilitiesWebsite: www.benetech.orgOverview video: https://youtu.be/S3MD9Pqyy9g

Duke UniversityDeploying low-cost technologies and protocols to U.S. neurorehabilitation therapists and training them to use with patients at centers or on virtual reality platformsWebsite: https://www.duke.eduOverview video: https://youtu.be/gOFj5rsOBIA

University of California San Francisco Global Health GroupFighting vector-borne diseases like malaria and dengue by mobilizing communitiesWebsite: globalhealthsciences.ucsf.eduOverview video: https://youtu.be/rm_zEAbaDAs

CLEAN WATER AND SANITATION

ASU Foundation for A New American UniversityDemocratizing access to safe drinking water through a new technology—“drinking water solar panels”Website: asufoundation.orgOverview video: https://youtu.be/XQOMDQpO4DM

Carnegie Mellon UniversityRemoving micropollutants from water using a new affordable, green technologyWebsite: http://www.cmu.eduOverview video: https://youtu.be/e-V52oFl7ms

Columbia UniversityDesigning innovative technical and financial models to improve water and sanitation infrastructureWebsite: http://www.columbia.eduOverview video: https://youtu.be/qK2dYvXTkkU

Duke UniversityImproving sanitation and empowering women through business development in Gujarat, IndiaWebsite: https://www.duke.eduOverview video: https://youtu.be/OB_V8KDj5y0

Evidence ActionProviding safe drinking water through the distribution of bacteria killing chlorine dispensersWebsite: https://www.evidenceaction.orgOverview video: https://youtu.be/J82jpemNbPc

Fundação Banco do BrasilCollecting and storing rainwater in Brazil for drinking, cooking, and irrigation during the dry seasonWebsite: www.fbb.org.brOverview video: https://youtu.be/hbtiPOSybwA

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Clean Water and Sanitation continued

The Ohio State UniversityBuilding sustainable solar-powered water systems in Tanzanian villagesWebsite: https://www.osu.eduOverview video: https://youtu.be/kOtwH9uVJ9o

The Regents of the University of California, Berkeley CampusEliminating arsenic in drinking water in India and rural CaliforniaWebsite: http://www.berkeley.eduOverview video: https://youtu.be/WcjLXoCdSZg

Safe Water NetworkProviding safe water in Ghana and India through microenterpriseWebsite: http://www.safewaternetwork.orgOverview video: https://youtu.be/5lJfgzkLmkM

Stony Brook UniversityPurifying drinking water with nanotechnology and micro-enterprisesWebsite: www.stonybrook.eduOverview video: https://youtu.be/CENb3c5-dX4

Water For PeopleEmploying off-grid decentralized sanitation systems to recover energy and nutrients from human wasteWebsite: https://www.waterforpeople.orgOverview video: https://youtu.be/jLJ9ms5ViPw

CONSERVATION AND BIODIVERSITY

American Bird Conservancy/Alliance for Zero ExtinctionPreventing global species extinction through land conservation and protectionWebsite: www.abcbirds.org/, www.zeroextinction.orgOverview video: https://youtu.be/KICpAr5Ha7Y

Arizona State UniversityExpanding the Sustainability Consortium Index to promote conservation in the supply chainWebsite: www.asu.eduOverview video: https://youtu.be/L9w3HeII9g8

Arizona State UniversityChanging the trajectory of rice-based cultures towards sustainabilityWebsite: www.asu.eduOverview video: https://youtu.be/hTHWnzT3agM

CAB International (CABI)Fighting invasive species in agriculture and natural ecosystemsWebsite: http://www.cabi.orgOverview video: https://youtu.be/CiO4FQ7WFfw

California Polytechnic State UniversityPromoting effective marine reserve management in the Western Indian OceanWebsite: www.calpoly.eduOverview video: https://youtu.be/cOqgc1KJj64

Environmental Defense FundPromoting sustainable fishing in Asia-Pacific oceansWebsite: https://www.edf.orgOverview video: https://youtu.be/Aargh5xfltw

E.O. Wilson Biodiversity FoundationCampaigning to conserve half the earth’s land and water to protect species and habitatWebsite: https://eowilsonfoundation.orgOverview video: https://youtu.be/VF1Anlpf4PM

Governors’ Climate and Forests Task ForceFighting deforestation through partnerships and collaborationWebsite: http://www.gcftaskforce.orgOverview video: https://youtu.be/Mj3O2-pGWOA

Mesoamerican Reef Fund IncProtecting the Mesoamerican Reef and surrounding communitiesWebsite: www.marfund.orgOverview video: https://youtu.be/OgXt3STQ1do

Oceana, Inc.Rebuilding wild fish stocks to promote good nutrition and healthWebsite: oceana.orgOverview video: https://youtu.be/g5XwIjFdYNE

Peace Parks FoundationConserving wildlife, supporting socio-economic development, and building security through cross national management of critical ecosystems in AfricaWebsite: http://www.peaceparks.orgOverview video: https://youtu.be/IwO8uVFZZDE

The Pew Charitable TrustsCombating illegal fishing through global tracking and enforcementWebsite: www.pewtrusts.orgOverview video: https://youtu.be/odRWDLrObgY

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Conservation and Biodiversity continued

The Rockefeller UniversityBuilding a Digital Noah’s Ark, cataloging genomes of endangered vertebratesWebsite: https://genome10k.soe.ucsc.eduOverview video: https://youtu.be/EwNR66FXwVk

San Diego Zoo GlobalPreserving plant and animal genetic material to fight extinctionWebsite: http://institute.sandiegozoo.orgOverview video: https://youtu.be/Qkkado7thro

Stitching the Ocean CleanupRemoving plastic waste from the oceanWebsite: https://www.theoceancleanup.comOverview video: https://youtu.be/rNkxaFrhGoI

CRIME, PUNISHMENT, AND REHABILITATION

American Bar Association Fund for Justice and EducationTransforming the public defender system in the United States to protect the right to counselWebsite: http://www.americanbar.org/groups/departments_offices/fund_justice_education.htmlOverview video: https://youtu.be/4SDDhw3wXDo

Bridges of IowaBreaking the cycle of drug abuse and unemployment by providing cognitive behavior-based substance abuse treatment in jail settingsWebsite: https://bridgesofiowa.orgOverview video: https://youtu.be/ng_IuHTPR9U

Harvard UniversityAddressing drugs as a public health issue through criminal justice diversion programsWebsite: http://www.harvard.eduOverview video: https://youtu.be/Ez4FJ9cUUL0

Prison Fellowship MinistriesReducing prison recidivism through education and reentry programsWebsite: https://www.prisonfellowship.orgOverview video: https://youtu.be/lS_X6eH-_6E

DISEASE CONTROL AND ERADICATION

Administrators of the Tulane Educational FundCombating emerging disease threats through surveillance, DNA sequencing, and trackingWebsite: Overview video: https://youtu.be/cOF-tjIgYZw

Broad Institute, Inc.Rapidly detecting and responding to infectious disease outbreaksWebsite: https://www.broadinstitute.orgOverview video: https://youtu.be/pUpgvR8_WE0

The Carter Center, Inc.Eliminating river blindness in NigeriaWebsite: https://www.cartercenter.orgOverview video: https://youtu.be/iWj2uWRoOJo

Helen Keller InternationalFighting podoconiosis in Africa through mapping, diagnostics, and educationWebsite: www.hki.orgOverview video: https://youtu.be/YhXhdRyUXOg

International Livestock Research Institute (ILRI)Preventing infectious diseases transmitted from livestock and wildlife to peoplehttps://www.ilri.orgOverview video: https://youtu.be/4G6e_w0zWx0

The Leprosy Mission InternationalControlling leprosy through prevention, early diagnosis, mapping, and treatmentWebsite: https://www.leprosymission.orgOverview video: https://youtu.be/oxgB6Af86WA

Monash UniversityDeploying bacteria that prevents mosquitoes from transmitting Zika, dengue, and chikungunyaWebsite: http://www.monash.eduOverview video: https://youtu.be/Dbk29Ksa1Vk

The Regents of the University of California, Santa BarbaraEliminating disease-carrying mosquitoes through genetic engineeringWebsite: www.ucsb.eduOverview video: https://youtu.be/OoB49KlHUtA

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Disease Control and Eradication continued

The University of ChicagoEradicating human Toxoplasma gondii, a single-celled parasite, and the infection and diseases it causesWebsite: www.uchicago.eduOverview video: https://youtu.be/Iqlugqtz2JM

Washington State UniversityEliminating rabies in sub-Saharan AfricaWebsite: https://wsu.eduOverview video: https://youtu.be/3uk-lgA5kIc

DISEASE THERAPY AND TREATMENT

The Chancellor, Masters and Scholars of the University of CambridgeDeveloping personalized treatment approaches for dementiaWebsite: http://www.cam.ac.ukOverview video: https://youtu.be/D9KKxKh0nGI

Jhpiego CorporationFighting cervical cancer through vaccination, screening, and treatmentWebsite: https://www.jhpiego.orgOverview video: https://youtu.be/5PeY49pC1Uo

MiracleFeetTreating club foot without surgeryWebsite: www.miraclefeet.orgOverview video: https://youtu.be/pr1lB8aPSH0

Northwestern UniversityFighting cancer through early detection and the development of new therapiesWebsite: https://osr.northwestern.eduOverview video: https://youtu.be/Sf_Wi1LJ_Bs

NYU Langone Medical CenterGenetically engineering pigs to produce organs for human transplantWebsite: nyulangone.orgOverview video: https://youtu.be/POzNIbvJc48

Operation Smile Inc.Promoting and delivering safe cleft surgeries in low-income global communitiesWebsite: www.operationsmile.orgOverview video: https://youtu.be/JJ06xlDTs4Y

President and Fellows of Harvard CollegeGenerating long-term, viable, and safe, cell therapy treat-ments for patients with ALS, diabetes, Duchenne muscular dystrophy, heart failure, and musculoskeletal diseaseWebsite: http://www.harvard.edu/about-harvard/harvards- leadership/president-and-fellows-harvard-corporationOverview video: https://youtu.be/Oz32SDrT0q4

University Hospitals Health System, Inc.Developing new drugs for rare diseasesWebsite: www.uhhospitals.orgOverview video: https://youtu.be/lFxHGPOIQ2w

University of North Carolina at Chapel HillDeveloping low-cost, low-intensity cancer interventions in Malawi and scaling an evidence-based project to low and middle-income countriesWebsite: www.unc.eduOverview video: https://youtu.be/vPhbvSZAksY

The University of Texas at AustinDeveloping radio-isotopes to treat cancer, heart disease, and infectionWebsite: http://www.utexas.eduOverview video: https://youtu.be/PqEZy34mBU0

The University of Texas Health Science Center at HoustonPreventing brain disease through early detectionWebsite: https://www.uth.eduOverview video: https://youtu.be/7AVP6OAqJrE

University of Washington Center for Dialysis InnovationMaking dialysis accessible and convenientWebsite: cdi.washington.eduOverview video: https://youtu.be/vjcqjJDoAwQ

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ECONOMIC OPPORTUNITY

B Lab CompanyCreating a global network of certified benefit corporations to change the trajectory of capitalism, reducing inequality and povertyWebsite: http://www.bcorporation.netOverview video: https://youtu.be/OlF1KAC4IqY

BRAC USAEradicating extreme poverty for 300,000 people in Uganda and Tanzania through a series of interdependent interventions within householdsWebsite: https://www.bracusa.orgOverview video: https://youtu.be/epJ-ENcNTNI

Friends of WWB USA INCEmpowering girls through financial education and savings programsWebsite: https://www.womensworldbanking.orgOverview video: https://youtu.be/JpKU1yOezE4

Generation LLCFiguring out what works in youth employment training worldwideWebsite: Overview video: https://youtu.be/5X45iEJiGeI

GO Fintech LLC dba MeedOffering affordable and accessible banking via mobile phonesWebsite: https://meed.netOverview video: https://youtu.be/7IKk24ZVGJ0

Goodwill Industries InternationalHelping adults get high school diplomas and continue their educationWebsite: http://www.goodwill.orgOverview video: https://youtu.be/HxQjnygaO-8

Reading and BeyondBreaking cycles of poverty through wrap-around services, education, and workforce developmentWebsite: http://www.readingandbeyond.orgOverview video: https://youtu.be/G89HLYyDUyo

Tostan, Inc.Scaling a community empowerment program in Guinea-Bissau, the Gambia, and Senegal to unlock the leadership potential of women and girls and achieve progress on economic and human development indicatorsWebsite: www.tostan.orgOverview video: https://youtu.be/jeXmQG3eyyo

EDUCATION

ChildFund InternationalEnding child labor through education and economic supportWebsite: https://www.childfund.orgOverview video: https://youtu.be/GVaKsu4m9w4

Gooru Inc.Designing free, virtual, interactive, and personalized STEM learning tools for middle and high school studentsWebsite: https://www.gooru.orgOverview video: https://youtu.be/uP71bISDC1c

IBM CorporationIncreasing literacy through free smart phone-based personal learning programsWebsite: https://www.ibm.comOverview video: https://youtu.be/Psx_YierLPs

Khan AcademyDeveloping internationally-recognized diplomas for worldwide education and job accessWebsite: https://www.khanacademy.orgOverview video: https://youtu.be/yOP0R4GaoeY

Leland Stanford Junior University and NextGenU.orgProviding free higher education to train health care workersWebsite: lsjumb.stanford.edu/, NextGenU.orgOverview video: https://youtu.be/LdoaTbhsEgo

Library For AllCreating a global library of free e-booksWebsite: http://www.libraryforall.orgOverview video: https://youtu.be/1x6F4fmBtZM

OneSky for All ChildrenBuilding local capacity to provide early interventions to unlock the potential of at-risk children in AsiaWebsite: onesky.orgOverview video: https://youtu.be/S9mxsqx3FLo

Playworks Education EnergizedLeveraging play to develop empathy and conflict resolution skills among young childrenWebsite: http://www.playworks.orgOverview video: https://youtu.be/5VVMgscGv3Y

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ENVIRONMENTAL HEALTH

Trustees of Indiana UniversityMapping chemical exposure and toxicity to protect human healthWebsite: http://trustees.iu.eduOverview video: https://youtu.be/QZTW_y3MSR8

Virginia TechFacilitating community-based science to guard against toxic environmental exposuresWebsite: https://www.vt.eduOverview video: https://youtu.be/j8Y2Q7WPLOE

Education continued

The Sapling FoundationDeveloping online short video lessons on non-traditional subjects to spark creativity and curiosityWebsite: https://youtu.be/5HjjDDtPc04

WorldreaderPromoting literacy and reading through digitized books and online toolsWebsite: https://www.worldreader.orgOverview video: https://youtu.be/MBeP6saOVXc

FOOD SECURITY

BAIF Development Research FoundationFighting malnutrition by deploying solar-powered technology for drying fruits and vegetablesWebsite: www.baif.org.inOverview video: https://youtu.be/mz2sPE8Pl28

Carnegie Mellon UniversityDeveloping perennial staple crops in sub-Saharan AfricaWebsite: www.cmu.eduOverview video: https://youtu.be/aA7NxHgqWRw

Cornell UniversityRevitalizing degraded agricultural soil in semi-arid regionsWebsite: https://www.cornell.eduOverview video: https://youtu.be/rxEDKfAXfKE

Forever Oceans CorporationProviding sustainable seafood through deep ocean seafood farmingWebsite: www.foreveroceans.comOverview video: https://youtu.be/RnVvA5qyDjI

HarvestPlusEliminating hidden hunger in Africa by fortifying staple cropsWebsite: http://www.harvestplus.orgOverview video: https://youtu.be/2NdmuTwgOqM

International Plant Genetic Resources Institute operating as Bioversity InternationalReviving “forgotten crops” and reducing unsustainable meat consumptionWebsite: http://www.bioversityinternational.orgOverview video: https://youtu.be/Ya4KndJ1QtE

Iowa State UniversityDeveloping crops with enhanced nutrient contentWebsite: https://www.iastate.eduOverview video: https://youtu.be/6Yw_9qJgSuk

Johns Hopkins UniversityProtecting honeybees by developing and deploying natural toxins against Varroa mitesWebsite: https://www.jhu.eduOverview video: https://youtu.be/Qw4yoAqAu_Y

Massachusetts Institute of TechnologyLeveraging microbes to provide nitrogen and phosphorus to crops and minimize harmful fertilizer useWebsite: http://web.mit.eduOverview video: https://youtu.be/61C0B-dK3o8

Northeastern UniversityTransforming mariculture, supplanting livestock production, and industrial fishing, to provide sustainable, healthy animal protein to a growing human populationWebsite: https://www.northeastern.eduOverview video: https://youtu.be/Pqk4oKgqCJg

Oz Harvest LimitedDistributing surplus food to avoid waste, reduce carbon emissions, and fight hungerWebsite: www.ozharvest.orgOverview video: https://youtu.be/nfhiRnTLGVU

Purdue UniversityStoring grain without using insecticides to increase farmers’ incomes, improve food security, and decrease health risksWebsite: www.purdue.eduOverview video: https://youtu.be/EAlc5EIrUco

Texas A&M AgriLife ResearchDeveloping genetically engineered rice with high yields and low greenhouse gas emissions in tropical climatesWebsite: agriliferesearch.tamu.eduOverview video: https://youtu.be/Q5UsFMeEnRo

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Food Security continued

University of California Davis (UC Davis)Developing crop drying and storage systems to prevent food waste and contaminationWebsite: https://www.ucdavis.eduOverview video: https://youtu.be/-Xahy8rETEQ

University of California San DiegoCultivating algae as a sustainable source of dietary proteinWebsite: https://ucsd.eduOverview video: https://youtu.be/85wqMSqSbz4

University of MinnesotaProtecting Upper Midwest U.S. soil and water through cover crops that prevent erosionWebsite: https://twin-cities.umn.eduOverview video: https://youtu.be/6MUBhqlnmMY

The University of SydneyDeveloping new wheat strains fortified with zinc and ironWebsite: https://sydney.edu.auOverview video: https://youtu.be/Hf_s05oUizE

World Agroforestry CentreRestoring land threatened by deforestation, over-grazing, and charcoal production in several sub-Saharan African regionsWebsite: http://www.worldagroforestry.orgOverview video: https://youtu.be/a8tALDwT1t4

World Wildlife Fund, Inc.Fighting food waste through incentives, market tools, and metricsWebsite: www.worldwildlife.orgOverview video: https://youtu.be/yHb_ZU3Zcq0

HEALTH BEHAVIORS

American Heart AssociationReducing children’s consumption of unhealthy sugary drinks through policy reform and educationWebsite: www.heart.orgOverview video: https://youtu.be/FKTVhdkJYV0

The George Institute for Global Health BehaviorsCataloging the global food supply and using the data to enhance nutrition and improve dietsWebsite: http://www.georgeinstitute.org/units/food-policyhttps://youtu.be/19d4Vwtk9Ck

The Trustees of the University of PennsylvaniaImproving life and health through behavior change interventionsWebsite: www.upenn.eduOverview video: https://youtu.be/7dUUqtRQG_Y

Tufts UniversityPromoting healthy eating in the U.SWebsite: https://www.tufts.eduOverview video: https://youtu.be/ENs9vhM9lOM

University of California, San Francisco (UCSF) Center for Vulnerable PopulationsMobilizing youth to prevent diabetesWebsite: https://cvp.ucsf.eduOverview video: https://youtu.be/skj4TdHSW00

HEALTH CARE DELIVERY

Colorado State UniversityAdvancing access to radiotherapy for cancer patientsWebsite: http://www.colostate.eduOverview video: https://youtu.be/zL9SqLCyqjM

Health Leads, Inc.Making social needs like housing and nutrition an intrinsic part of health care provisionWebsite: https://healthleadsusa.orgOverview video: https://youtu.be/D0JMolG0MY0

HudsonAlphaPromoting proactive healthcare through deployment of genomic-guided medicine into the public health systemWebsite: hudsonalpha.orgOverview video: https://youtu.be/hbHFjY8fc6k

Human Dx, Ltd. / Human Diagnosis Project, Ltd.Providing virtual access to specialist medical care for underserved U.S. patientsWebsite: https://www.humandx.orgOverview video: https://youtu.be/TarS4K3eoss

Northwestern UniversityEstablishing a new model of primary care in underutilized Chicago schools by making high-quality care locally accessibleWebsite: www.northwestern.eduOverview video: https://youtu.be/APG4JwCZVR0

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Health Care Delivery continued

The Ohio State University Comprehensive Cancer CenterPreventing cancer through screening and surveillance of genetically high-risk individualsWebsite: https://cancer.osu.edu/about/locations/the-james-cancer-hospital-and-solove-research-instituteOverview video: https://youtu.be/p6rYBgNvTbY

Partners In HealthDeploying community health workers with modern digital toolsWebsite: http://www.pih.orgOverview video: https://youtu.be/tf57U990z1U

President and Fellows of Harvard CollegeStrengthening the delivery of surgical care in Sierra LeoneWebsite: http://www.harvard.edu/about-harvard/harvards- leadership/president-and-fellows-harvard-corporationhttps://youtu.be/lIx9-cn9-ZA

The Trustees of Columbia University in the City of New YorkPromoting maternal and infant health through technology and community engagementWebsite: http://secretary.columbia.edu/trustees-columbia-universityOverview video: https://www.youtube.com/watch?v=oj_fU_i7kjw

HOUSING AND HOMELESSNESS

Community Solutions International, Inc.Ending chronic homelessness through supportive housingWebsite: www.cmtysolutions.orgOverview video: https://youtu.be/3lti4taioP8

Foundation for Charitable Activities in Bangladesh (FCAB)Resettling climate refugees from Bangladesh’s coastlinesWebsite: www.fcabd.orgOverview video: https://youtu.be/Cg-pKQ4_-HA

Project HOMEFighting chronic homelessness through housing and holistic case managementWebsite: https://projecthome.orgOverview video: https://youtu.be/dY9QKXhpatI

Vermont Energy Investment CorporationFacilitating home-ownership and car-sharing for lower income familiesWebsite: https://www.veic.orgOverview video: https://youtu.be/xK4p6IgEddY

HUMAN TRAFFICKING

Seattle FoundationFighting sex trafficking and sexual exploitation by reducing demand and changing normsWebsite: www.endingexploitation.comOverview video: https://youtu.be/nXPnVzO84Xw

INFORMATION AND MEDIA ACCESS AND INCLUSION

The Internet ArchiveProviding digital access to four million booksWebsite: https://archive.orgOverview video: https://youtu.be/5eMqwgFEavA

The University of EdinburghProviding robust, affordable, solar-powered internet access to remote regionsWebsite: www.ed.ac.ukOverview video: https://youtu.be/sM9bc8OSwdU

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MEDICAL INFORMATICS

Children’s Medical Research InstituteAnalyzing cancer samples and treatment outcomes worldwide for a digitized libraryWebsite: http://www.cmri.org.auOverview video: https://youtu.be/moFdZ6WM_wM

Curoverse, Inc.Creating a high quality public resource of genomic and health data to inform disease diagnosis and treatment with the help of well-consented participantsWebsite: curoverse.com/100andChangeOverview video: https://youtu.be/de7y-kJCS5U

The Regents of the University of MichiganProviding health monitoring tools and education for people with chronic diseaseWebsite: www.regents.umich.eduOverview video: https://youtu.be/b74f7b6BYkQ

Sanford ResearchImproving health care in isolated areas through data and telemedicineWebsite: www.sanfordresearch.orgOverview video:

State University of New York at BuffaloDeveloping a platform to screen and rank all human-use drugsWebsite: http://www.buffalo.eduOverview video: https://youtu.be/2tI8RZXYO-M

University of California San DiegoMapping cancer cell genomes to develop personalized treatmentsWebsite: https://ucsd.eduOverview video: https://youtu.be/LHs312JNbUw

MATERNAL AND REPRODUCTIVE HEALTH

American College of Obstetricians and GynecologistsFighting maternal death during childbirth through training and community careWebsite: www.acog.orgOverview video: https://youtu.be/h2CoJX1OvYU

ayzh, Inc.Providing women affordable, culturally relevant products that support childbirth, newborn and postpartum health, and menstrual hygieneWebsite: www.ayzh.comOverview video: https://youtu.be/IefFrQ0PdfU

DKT International. Inc.Expanding access to contraception through leveraging existing commercial infrastructure in the developing worldWebsite: www.dktinternational.orgOverview video: https://youtu.be/viIkd-uezu0

Living GoodsTraining community health workers to improve basic health care in AfricaWebsite: https://livinggoods.orgOverview video: https://youtu.be/9mfmIcAHuWQ

MSI-USDeploying 20,000 community health workers across Africa to provide reproductive health servicesWebsite: Overview video: https://youtu.be/orcPuqpRJQY

Praekelt Foundation NPCImproving maternal and infant health through mobile phone based health messagingWebsite: www.praekelt.orgOverview video: https://youtu.be/ga21TWQG9OI

Regents of the University of MichiganEliminating preventable maternal and early neonatal death in sub-Saharan Africa through OBGYN trainingWebsite: http://www.regents.umich.eduOverview video: https://youtu.be/z_wdrhKKVis

INTERNATIONAL PEACE AND SECURITY

Polis Center, Indiana University Purdue University, IndianapolisEradicating land mines through technology, mine removal, advocacy, and educationWebsite: http://polis.iupui.eduOverview video: https://youtu.be/krYwxL-ltMM

Project for Public SpacesEmpowering community members to transform public urban spacesWebsite: https://www.pps.orgOverview video: https://youtu.be/bMePTc4WHmM

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Medical Informatics continued

University of ChicagoCreating a massive open database of cancer genomic data, facilitating research and treatmentWebsite: www.uchicago.eduOverview video: https://youtu.be/7paZO4xRm4U

University of North Carolina at Chapel HillIndexing under-studied proteins in the human genome to facilitate drug research and developmentWebsite: http://www.unc.eduOverview video: https://youtu.be/JO7Eg6Kc-qk

Vanderbilt University Medical CenterCataloging human immune system genes to understand diseases and find curesWebsite: https://ww2.mc.vanderbilt.eduOverview video: https://youtu.be/gPdwiNUEkkM

MENTAL HEALTH

Board of Regents of The University of Texas SystemImproving screening and care for serious mental illness in TexasWebsite: https://www.utsystem.edu/board-of-regentsOverview video: https://youtu.be/QjpqQIu2dC4

Crisis Text LineEstablishing a global, text-based hotline service for suicide and mental health counselingWebsite: http://www.crisistextline.orgOverview video: https://youtu.be/mgue7zX6pp8

Florida Institute of TechnologyCreating a web-based hub for screening and treatment of autismWebsite: www.fit.eduOverview video: https://youtu.be/CRpLv9g1mn0

Give an HourChanging the culture around mental health in the U.S.A. through education and outreachWebsite: https://www.giveanhour.orgOverview video: https://youtu.be/ljIRU8iXudo

Grand Challenges CanadaProviding universal mental health care through evidence-based community solutionsWebsite: www.grandchallenges.caOverview video: https://youtu.be/QvjvgYtGbOM

The Regents of the University of California - on behalf of the UCLA campusPreventing and treating depression in poorly resourced areasWebsite: regents.universityofcalifornia.eduOverview video: https://youtu.be/qokoJ_FtTIY

Southcentral FoundationProviding mental health care, basic needs, and mentoring to Alaska Native families and childrenWebsite: https://www.southcentralfoundation.comOverview video: https://youtu.be/0SZl66rtMps

NEWBORN HEALTH

Save the Children Federation, Inc.Reducing neonatal mortality by preventing infections, ensuring warmth, and providing optimal feedingWebsite: www.savethechildren.orgOverview video: https://youtu.be/ffOuRMRN0K0

William Marsh Rice UniversityImproving newborn survival in AfricaWebsite: http://www.rice.eduOverview video: https://youtu.be/o_WJDA1EgT4

100&CHANGE TOP 200 APPLICANTS

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PUBLIC SECTOR CAPACITY BUILDING

The Board of Trustees of the Leland Stanford Junior UniversityCreating tools for data-driven public policyWebsite: http://facts.stanford.edu/administrationOverview video: https://youtu.be/H808rP-lh5w

University of TorontoCollecting data on death in Asia and Africa, facilitating study of mortality and climate changeWebsite: https://www.utoronto.caOverview video: https://youtu.be/ZIgkMkIbGPo

what3wordsMapping and creating addresses for informal settlements, enabling government services and health careWebsite: what3words.comOverview video: https://youtu.be/KPiD-gkBsqs

PRIVACY RIGHTS

Consumers Union of United States, Inc., dba Consumer ReportsProtecting consumers in the digital marketplaceWebsite: http://consumersunion.orgOverview video: https://youtu.be/w5SEAE3-uXo

REFUGEES AND VICTIMS OF CONFLICT

Sesame WorkshopEducating children displaced by conflict and persecutionWebsite: www.sesameworkshop.orgOverview video: https://youtu.be/99qeQSTmSaw

Southern New Hampshire UniversityProviding higher education and accredited degrees to refugees in emergency situationsWebsite: http://www.snhu.eduOverview video: https://youtu.be/F33g_Y8OnoE

RACIAL, ETHNIC AND GENDER JUSTICE, EQUITY, AND INCLUSION

Johns Hopkins UniversityFostering social cohesion in Baltimore neighborhoods and developing a template for inclusive revitalization for U.S. citiesWebsite: https://www.jhu.eduOverview video: https://youtu.be/zPTI82oawfY

Pro MujerEmpowering women in Latin America through financial opportunities, health care, and support for victims of violenceWebsite: promujer.orgOverview video: https://youtu.be/yINr8rwD1z8

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RESILIENCE AGAINST CLIMATE CHANGE AND ENVIRONMENT

Aclima, Inc.Deploying networked air pollution sensors in 50 cities worldwideWebsite: https://aclima.ioOverview video: https://youtu.be/1Lwo-IXbs8g

Climate Policy InitiativeDeveloping financial tools for investment in climate change mitigation and adaptationWebsite: https://climatepolicyinitiative.orgOverview video: https://youtu.be/fUkxxDxY6Bc

Deakin UniversityProtecting coastal zone carbon sinks to combat climate change and provide resourcesWebsite: www.deakin.edu.auOverview video: https://youtu.be/mGFy7nyWh0c

Dioxide Materials, Inc.Demonstrating new approaches to carbon capture and fuel productionWebsite: https://dioxidematerials.comOverview video: https://youtu.be/HU9z6nuDwCM

Ecology Action of the MidpeninsulaUsing organic farming principles to improve soil capacity, crop yields, and financial outcomes for small farmersWebsite: http://www.growbiointensive.orgOverview video: https://youtu.be/zNZhNkuRe-A

Greening Australia LimitedReducing sediment run-off to protect the Great Barrier ReefWebsite: https://www.greeningaustralia.org.auOverview video: https://youtu.be/G3U339JckBg

One Acre FundHelping small farmers in East Africa adapt to climate change and improve yieldsWebsite: https://www.oneacrefund.orgOverview video: https://youtu.be/H9HdfLhqAfM

Trustees of Princeton UniversityMonitoring ocean temperatures and climate change with floating autonomous robotsWebsite: https://www.princeton.edu/vpsec/trusteesOverview video: https://youtu.be/mFypYbuoWnE

University of South FloridaRestoring coral reefs with local stakeholdersWebsite: www.usf.eduOverview video: https://youtu.be/rsvqgxl6CVQ

RESILIENCE AGAINST CLIMATE CHANGE

Columbia UniversityIdentifying opportunities for coordinated behavior across countries to reduce greenhouse gas emissionsWebsite: www.columbia.eduOverview video: https://youtu.be/DGnRc_8JsVU

Environmental Defense FundReduce global warming by using science to pinpoint the sources of emissions and creating a campaign that generates the will for policymakers and the oil and gas industry to actWebsite: https://www.edf.orgOverview video: https://youtu.be/mdHzFLDriQ0

WWF BrasilFighting climate change, augmenting soil, and providing energy through decentralized production of biocharWebsite: http://wwf.panda.org/who_we_are/wwf_offices/brazilOverview video: https://youtu.be/oXPivLy6vCs

RESILIENCE AGAINST NATURAL DISASTERS

Rutgers, The State University of New JerseyPredicting catastrophic storms through undersea robotic glidersWebsite: www.rutgers.eduOverview video: https://youtu.be/d3tXLNBfYSQ

100&CHANGE TOP 200 APPLICANTS

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SOCIAL PROTECTION AND/OR SAFETY NETS

Catholic Relief Services - United States Conference of Catholic BishopsChanging how society cares for children in orphanagesWebsite: http://www.crs.orgOverview video: https://youtu.be/xECBsNPkOZ4

Institute for the FutureCreating a guild for workers across sectors nationwide, offering benefits, advocacy, and supportWebsite: www.dataforcities.orgOverview video: https://youtu.be/fiGQxvmulTQ

LIFE ElderCareExpanding Meals on Wheels food and service delivery to senior citizensWebsite: lifeeldercare.orgOverview video: https://youtu.be/kmIPhhJzYME

Plan International USA, Inc.Accelerating birth and death registrations in Ghana and Zambia to facilitate rights and servicesWebsite: https://www.planusa.orgOverview video: https://youtu.be/u0l1ZKTzSb0

Washington UniversityPreventing child maltreatment in the U.S. through restructuring public health and family service systemsWebsite: https://wustl.eduOverview video: https://youtu.be/6p7GufxeskU

SUSTAINABLE CITIES, COMMUNITIES, AND REGIONS

ASU Foundation for A New American UniversityRevolutionizing public health management, using data-driven decision-making, informed by near- real-time population health monitoringWebsite: https://www.asufoundation.orgOverview video: https://youtu.be/Kqq4nqAu4og

Habitat for Humanity InternationalRevitalizing distressed neighborhoods by connecting and organizing residentsWebsite: http://www.habitat.orgOverview video: https://youtu.be/vfChkVJ1Pz0

ISEAL AllianceTransforming business practices and promoting conservation through the adoption of sustainability standardsWebsite: www.isealalliance.orgOverview video: https://youtu.be/GuhQvHptPzM

RAND CorporationImproving life in rural U.S. communities through education, economic development, health, and technologyWebsite: www.rand.orgOverview video: https://youtu.be/Wsy6aKR-rys

The Regents of the University of ColoradoEnabling renewable ammonia production using concentrated sunlight, air, and water to facilitate improved use of farmable landWebsite: http://www.cu.edu/regentsOverview video: https://youtu.be/AqS74QYaIhU

Sustainability Leaders NetworkIdentifying place-based climate solutions through participatory engagement of local communitiesWebsite: www.sustainabilityleadersnetwork.orgOverview video: https://youtu.be/TXhzRPbKPSc

RURAL POVERTY

Evidence ActionReducing seasonal income insecurity among rural households through migration subsidiesWebsite: https://www.evidenceaction.orgOverview video: https://youtu.be/L_FjjT2D3rs

Shared-X LLCTeaching small cacao and coffee farmers sustainable farming practicesOverview video: https://youtu.be/fm3hUxMFqc8

Stanford UniversityProviding energy, education, health care, and sanitation for rural villagesWebsite: https://www.stanford.eduOverview video: https://youtu.be/BkPFONQ3u1I

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Sustainable Cities, Communities, and Regions continued

World Council on City DataFacilitating data-driven innovation in cities through a global open data platformWebsite: www.dataforcities.orgOverview video: https://youtu.be/aICnXZRl4pg

VACCINE DEVELOPMENT

Beth Israel Deaconess Medical CenterDeveloping a Zika virus vaccineWebsite: http://www.bidmc.orgOverview video: https://youtu.be/liEFKCQNqUw

Duke UniversityDeveloping an HIV vaccine that prevents infectionWebsite: https://www.duke.eduOverview video: https://youtu.be/9Uejb1lcv00

Icahn School of Medicine at Mount SinaiDeveloping an influenza vaccine that provides lifetime protection against diverse flu strainsWebsite: http://icahn.mssm.eduOverview video: https://youtu.be/-TpYUY9dL9g

Roswell Park Alliance FoundationDeveloping a vaccine targeted at lung cancer most common in smokersWebsite: www.roswellpark.orgOverview video: https://youtu.be/s2x0TZ6-quM

VISION CARE

Himalayan Cataract ProjectEliminating needless blindness in Nepal, Ethiopia, and GhanaWebsite: http://www.cureblindness.orgOverview video: https://youtu.be/hNu6xDhigMs

Seva FoundationProviding accessible and low-cost eye care in developing countriesWebsite: www.seva.orgOverview video: https://youtu.be/NnKrEUfOYng

Wynn Institute for Vision ResearchPreventing and curing blindness through basic and clinical research and novel clinical treatment modalitiesWebsite: www.wivr.uiowa.eduOverview video: https://youtu.be/SFCLXwm3rmY

John D. and Catherine T. MacArthur Foundation April 2017

100&CHANGE TOP 200 APPLICANTS

ABOUT THE MACARTHUR FOUNDATIONThe John D. and Catherine T. MacArthur Foundation supports creative people, effective institutions, and influential networks building a more just, verdant, and peaceful world. MacArthur is placing a few big bets that truly significant progress is possible on some of the world’s most pressing social challenges, including over-incarceration, global climate change, nuclear risk, and significantly increasing financial capital for the social sector. In addition to the MacArthur Fellows Program, the Foundation continues its historic commitments to the role of journalism in a responsible and responsive democracy; the strength and vitality of our headquarters city, Chicago.

For more information or to sign-up for news and event updates, please visit www.macfound.org.

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ADDITIONAL RESOURCESwww.100andchange.orgwww.macfound.org/8boldsolutionswww.macfound.org/perspectives-100change/