tpch research report 2014

Living & Breathing Research

2014

Data collection period 1 January to 31 December 2013

Living & Breathing | Research | Contents2

ContentsJayne Bancroft

4Cardiac Imaging Research Group

22Queensland Lung Transplant Service

50

6Message from Chair of Research Council

24In Vitro Human Heart Laboratory

52University of Queensland Thoracic Research Centre

8Adult Congenital Heart Disease Unit

28Christian Hamilton-Craig

55Core Thoracic Research Group

10Advanced Heart Failure and Cardiac Transplant Unit

30Anaesthesia Research Group

56James Walsh

12Cardiovascular Research Group

34Emergency Medicine Research Group

58Sleep Disorders Centre Research Group

14Cardiology Clinical Research Centre

38Critical Care Research Group

62Orthopaedic Research Group

18Cardiac Electrophysiology

42Innovative Cardiovascular Engineering and Technology Lab

65Dan Chambers

20Echocardiography Research Group

46Cystic Fibrosis Research Group

66Allied Health Ageing and Rehabilitation Research Group

Contents | Living & Breathing | Research 3

Allied Health Complex Chronic Disease Research Group

70Higher Research Degree Students

100

74Internal Medicine Dementia and Ortho Geriatrics Research Group

108Publications

78Oncology Services Research

121Journal Editorial Positions

80Nursing Research and Practice Development Centre

122Mike Watson

82Felicia Goh

84Grants

96The Prince Charles Hospital Foundation

97Research Partners

Support life saving research. Visit www.tpchfoundation.org.au

Living & Breathing | Research | Jayne Bancroft4

In the past seven years, Jayne

Bancroft has witnessed the direct

patient benefits of research. As the

hospital’s Mechanical Circulatory

Support Coordinator, she provides

care and expertise to people awaiting

a heart transplant.

Her career has almost been

predestined. Jayne left school wanting

to be a nurse, but wasn’t eligible to

start training until she was 19. Her first

nursing position was allocated by the

matron – the cardiothoracic intensive

care unit.

The experience took her to Saudi

Arabia as an Enrolled Nurse where

she worked in an Army hospital which

performed the country’s first heart

transplant. ‘I remember he was a lovely

13 year old boy,’ she says.

After a couple of years she returned to

England to complete her Registered

Nurse training, then moved to Bahrain

to work in a new cardiac surgery

centre. ‘The best part of the job was

that the coronary care nurses would

go out with the ambulance crews for

chest pain calls,’ she says.

Jayne returned to England to do her

cardiothoracic speciality at London

Chest Hospital and worked for 10

years in the Papworth Hospital ICU

as a senior nurse and teaching sister.

There she met Dr Keith McNeill from

the transplant program at TPCH.

When she and her husband decided to

move to Australia, Jayne already knew

where she wanted to work.

Jayne’s role in the transplant team

includes participating in preoperative

assessment and postoperative care,

as well as looking after patients with

ventricular assistance devices (VADs)

and training them and their families to

manage the devices.

VAD technology has rapidly

progressed from unwieldy pumps

attached to large machines to today’s

artificial heart, smaller than an apple,

connected to a battery less than half

the size of a shoebox.

For patients it means they’re no longer

stuck in a hospital bed. Some patients

are able to go home and live relatively

normal lives while they wait for a heart

transplant.

‘I love that the role has a lot of patient

contact and teaching,’ Jayne says. ‘I

learn something new every day about

the technology.’

The job has also allowed Jayne

to participate in device trials and

transplant research projects such

as an audit of infection rates and a

survey of VAD coordinators to look at

different practices across the world.

She hopes the questionnaire results

will be published and presented at

the international VAD coordination

meeting in Germany.

‘It’s very interesting data,’ she says.

‘There are great variances across sites

with things like discharge processes,

bloods, dressings, clinics. A lot of it

comes down to resources available in

different hospitals such as equipment

and staffing, but also the number of

implants they do.

‘We get a lot of great ideas from what

people are doing around the world.’

Jayne and fellow transplant nurse

Margaret Porra also coordinate the

regular nursing grand rounds lectures,

to share nursing practice and research

across the hospital.

Jayne Bancroft


Living & Breathing | Research | Chair of Research Council6

For 60 years, The Prince Charles

Hospital has always been ‘ahead of

the pack’ when it came to answering

the needs of the ever changing clinical

landscape. As researchers today, we

can look so much further by standing

on the shoulders of the giants who

made Prince Charles the world leading

cardio-thoracic centre for more than

half a century.

Originally commissioned as a part

of the national strategy to combat

tuberculosis, the then Brisbane Chest

Hospital was birthing some great

researchers right from the start.

Imagine the ingenuity of radiologist

Dr Jim Hood in the 1950s to rig up

the angiograph to a movie camera to

create moving images of the heart.

Necessity truly is the mother of

invention.

I am constantly impressed by the

passion and creativity of researchers

at The Prince Charles Hospital. Our

teachers and mentors weaned us

on a culture that nothing was too

hard, and no question should be

left unattempted. They inspired a

culture that encouraged clinicians and

scientists of all disciplines to look for

better, more effective, less dangerous

ways of improving patient outcomes.

Not knowing wasn’t good enough. The

‘Charlie’s way’ meant going the extra

yard, coming to the lab on your days

off, and being in the library till closing

time. Seeing a patient doing that bit

better was reward enough.

Achieving that improved outcome

takes an outstanding team. It starts

with the cleaners and wardies,

whose extra care results in the

lowest infection rate anywhere in

Australia. The team extends across all

the disciplines in the hospital – and

their extra effort and work is what

makes Prince Charles a great place

to work and research. Innovation and

research is ‘99% perspiration and 1 %

inspiration’.

It also includes our research partners,

granting bodies like our own The

Prince Charles Hospital Foundation

which continues to increase its

support of research in response to

the needs of our growing research

community, and the wider community

who give so generously to help others.

My mentor Dr John McCarthy used

to say: ‘Remember, you can probably

learn more from your patients than

you can ever hope to teach them.’

Research where the patient does

not feature prominently at the start,

middle and end, probably will never go

too far. Their bravery in facing illness,

whilst agreeing almost universally to

assist in studies always humbles me.

‘If it can help anyone else Dr, then I am

happy to help’ would be the answer to

the vast majority of research requests I

have ever made.

Whether we’re driven by the thrill of

discovery, the desire to ease suffering,

or the need to solve mysteries,

ultimately we’re all working to make

life better for our patients now

and the many who will come. The

wonderful thing about research is

even if we’re just trying to make life

easier for the person right in front

of us, the work will benefit people

around the world. As clinicians first

and foremost, our ultimate outcome is

improved patient outcomes through

improved understanding, investigation,

innovation, and integration of our work

into daily clinical practice.

I acknowledge and pay gratitude

to the generations of clinicians and

researchers who have come before

us. You have bestowed on us a great

and precious legacy. I can proudly say

that 60 years on, the researchers of

The Prince Charles Hospital nurture

and value the great gift you have left

us. Today’s researchers advance the

work you began all those years ago.

Their tools may be different, but their

burning desire to leave the world that

wee bit better continues unchanged.

On your behalf, and the patients that

will benefit through their work, I thank

and commend them.

Message from Chair of Research Council

Professor John Fraser

CHAIR, TPCH RESEARCH COUNCIL

8

5

Living & Breathing | Research | Adult Congenital Heart Disease Unit

Adult Congenital Heart Disease Unit

Congenital heart disease affects one

percent of Australian babies. In past

times, to be born with structural heart

abnormalities indicated likely death in

infancy or childhood.

Now, because of progress in medicine,

medical imaging, surgery and intensive

care, such children are able to be

treated and live to become adults. The

Adult Congenital Heart Unit cares for

such patients. We help teenagers with

congenital heart disease make the

transition from paediatric to adult care

and understand their heart problem so

they can start taking care of their own

health.

Our research addresses the quality of

life which we can offer to our young

patients born with heart defects.

We aim to elucidate the medical and

psychological problems of these

young people and to remedy all we

can. Those in whom we elucidate

psychological problems are given face

to face or telephone support and they

are taught coping mechanisms.

HIGHLIGHTS

A major achievement has been the

Australia wide and New Zealand

cooperative research looking at

various aspects of those born with

the most severe congenital heart

defects. They are the ones treated by

complex surgery known as the Fontan

operation.

A National Health and Medical

Research Council Partnership

Project Grant for $ 1,125,000 has

been awarded for ongoing work in

Australasia for the next five years.

Scientific report papers from this work

are well received internationally, as the

studies involve the entire experience

of two countries.

GRANTS

The unit is part of an Australasian

research collaboration which received

an NHMRC Partnership Project grant

of $1,250,000 over the next five years.

The project will look at giving an adult

life after Fontan surgery to those

with the most severe congenital heart

conditions.

Associate Professor Dorothy Radford

RESEARCH HEAD

Researchers

PUBLICATIONS AND PRESENTATIONS

There were five publications including

a chapter in an Adolescent Medicine

book. The latter aimed to educate

students and doctors about congenital

heart problems.

Our staff gave educational and

scientific presentations at national

Echocardiography and Cardiology

meetings, as well as at the World

Congress of Paediatric Cardiology and

Cardiac Surgery in South Africa.

AWARDS

Theresa Malpas our Clinical Nurse

Consultant in Adult Congenital

Heart Disease was awarded The

Prince Charles Hospital Outstanding

Achievement Award in 2013.

RESEARCH STUDENTS

The group has one PhD candidate in

Psychology.

RESEARCH COLLABORATIONS

The Adult Congenital Heart Unit

collaborates with the University of

Queensland School of Psychology,

Royal Children’s Hospital Melbourne,

and the ANZ Fontan Registry.

9

NHMRC Partnership Project grant

$1,250,000

Congenital heart disease affects one percent of Australian babies.

Adult Congenital Heart Disease Unit | Living & Breathing | Research

10 Living & Breathing | Research | Advanced Heart Failure and Transplant Unit

Advanced Heart Failure and Cardiac Transplant Unit

The Advanced Heart Failure and

Cardiac Transplant Unit is a clinical

care service with an active program

encouraging research into aspects

of the unit’s clinical care provision,

namely advanced heart failure and

cardiac transplant.

It therefore encompasses various

studies into aspects of the diagnosis

and care of patients with advanced

heart failure, recipients of heart

transplants, and those who receive

follow up via Telehealth.

The group aims to improve the

outcomes of transplant recipients

and people with heart failure, improve

selection and outcomes for patients

requiring ventricular assist devices,

and enhance health care for rural and

remote patients by using Telehealth.

The individual patients themselves

benefit from closer follow up and

greater contact with clinical staff.

Their participation provides the data

towards research of techniques and

technologies that may later benefit

patients.

HIGHLIGHTS

This year showed the strength of the

allied health and nursing staff of the

Advanced Heart Failure and Cardiac

Transplant Unit in promoting further

research into the issues seen and

addressed by non-medical staff in the

care of these patient groups.

Most prospective clinical studies were

in the allied health and nursing arenas.

A few ongoing clinical studies from

earlier years continued throughout the

study period producing more data,

with those studies still yet to conclude.

Junior medical staff within the team

contributed a number of presentations

on aspects of ventricular assist devices

and sleep disordered breathing in

heart failure patients.

Dr Scott McKenzie

RESEARCH HEAD


Advanced Heart Failure and Transplant Unit | Living & Breathing | Research 11


Our publications and presentations

for the year covered a broad

multidisciplinary range of topics

in heart failure and cardiac

transplantation.

Published articles included a case

report on an unusual cause of right

ventricular outflow tract obstruction

and a pilot study into the role of

thermal underwear in reducing

hospitalisation in heart failure patients

over winter.

Presentations included topics such as

mobilisation of heart failure patients,

data that might better predict

outcomes in ventricular assist device

patients, new echocardiography

techniques for evaluation of

pulmonary hypertension, and the

role of screening for sleep disordered

breathing in heart failure patients.

GRANTS

The unit received a New Investigator

grant from The Prince Charles Hospital

Foundation to complete the OAT

Study (Obesity and Activity in heart

Transplant recipients) investigating the

relationship between overall activity

levels in heart transplant recipients

and their levels of obesity.


We have research collaborations with

Australian Catholic University School

of Nursing and Midwifery, Institute of

Nursing Science in Basel Switzerland,

and Bayer in Germany.

12 Living & Breathing | Research | Cardiovascular Research Group

Cardiovascular Research Group

Aortic aneurysm disease and the

associated conditions affect young to

middle aged adults. It is a silent but

life threatening condition. The risk of

death is high in untreated aneurysm

and surgical repair is the only effective

treatment. Despite extensive studies

of aortic aneurysm the cause is not

known.

Based on data from post mortem

studies there are approximately

3000 deaths pa in Australia

from thoracic or aortic aneurysm

complications - about 500 deaths

pa in Queensland. Understanding

the genetic mechanisms underlying

aneurysm development will aid in the

identification of subjects at risk.

This has the potential to identify new

therapeutic approaches. The research

will be beneficial for targeting specific

treatments or preventative steps to

eliminate aneurysm disease. New

approaches will minimise the need

for repeated surgical procedures and

improve quality of life for subjects with

this common abnormality.

Our research may assist in finding

novel treatment and prevention of

aortic aneurysm and the identification

of genetic and environmental risk

factors.

We have used animal models to

identify early changes prior to

disease development to determine

pathophysiological mechanisms

underlying aneurysm and dissection.

Furthermore therapeutic approaches

in animals to determine the effects of

inhibition or slowing down of disease

progression are also being examined.

In clinical studies in patients with

aneurysm we conduct special clinics

and collect samples of aneurysm

tissue at surgery to compare findings

from our animal work. Genetic

variants can influence cellular and

connective tissue metabolism and are

likely to contribute to pathological

abnormalities.

We are focussed on identifying

mechanisms that might be influenced

to benefit patients at risk as well as

instituting demonstrated preventative

measures.

In an animal model we are assessing

the efficacy of angiotensin II inhibition

on aortic aneurysm prevention

and slowing down of aneurysm

progression. The completion of this

study may help to identify targets for

drug intervention as well as identifying

preventative measures.

HIGHLIGHTS

We are collaborating with Dr Fraser

Russell from the University of the

Sunshine Coast. The ongoing research

is in the topic of aortic aneurysm using

mice models investigating the efficacy

Professor Malcolm West

RESEARCH HEAD

4Rese

arc

hers

13Cardiovascular Research Group | Living & Breathing | Research

of dietary supplementation with

omega-3 polyunsaturated fatty acids

in aortic aneurysm development. We

have joint supervision of 1 PhD student

and 3 Honours students.

We are setting up a collaboration with

BakerIDI Heart & Diabetes Institute

in Melbourne where Professor Alex

Bobik and Dr Tin Soe Kyaw have an

established animal model designed to

investigate the role of B and T cells in

the development of atherosclerosis.

Our project will investigate the role of

B and T cells in the development of

aortic aneurysm.

Our research with Dr S Prabowo from

Hang Tuah Medical School in Surabaya,

Indonesia, includes an ongoing project

on the role of hyperbaric treatment in

diabetic wound healing.

Dr Maria Nataatmadja was invited as a

speaker in the International Workshop

& Symposium on Medical Hyperbaric

Oxygen Treatment and the 1st National

Congress of the Indonesian Hyperbaric

Medical Association.


In 2013 we have published our

research as abstracts of national and

international conferences as well as full

papers in peer-reviewed journals.

Our research was presented at the

American Society for Bone and

Mineral Research annual meeting in

Baltimore, the Australian Vascular

Biology Society annual meeting in

South Australia, and as one of the top

rated abstracts at The Prince Charles

Hospital annual research forum.

Dr Maria Nataatmadja was invited as a

speaker in the International Workshop

& Symposium on Medical Hyperbaric

Oxygen Treatment and the 1st National

Congress of the Indonesian Hyperbaric

Medical Association in Surabaya in

November 2013.

We published journal articles on

whole exome sequencing for mutation

detection in osteogenesis imperfecta

and Marfan syndrome, the effects of

angiotensin II inhibition, and influenza

in chronic obstructive pulmonary

disease patients.

We have had a paper accepted for

publication in Health, titled ‘Hyperbaric

oxygen treatment in a diabetic rat

model is associated with a decrease

in blood glucose, regression of organ

damage and improvement in wound

healing’ by Sulistiana Prabowo, Maria

Nataatmadja, Janto Poernomo Hadi,

Irmawati Dikman, Fitri Handajani,

Sihning EJ Tehupuring, Iswahyudi,

Mohammad Guritno Suryokusumo,

Aulanni’am, Anita Herawati, Malcolm

West.

GRANTS

The group received over $200,000 in

grants including $30,000 from Medical

Advances Without Animals, and two

experienced researcher project grants

from The Prince Charles Hospital

Foundation.

RESEARCH STUDENTS

Professor M West had a supervisory or

advisory role with eight higher degree

candidates during 2013, including

two PhD candidates and six MPhil

students.


Our research group collaborates with

the University of the Sunshine Coast,

BakerIDI Heart and Diabetes Institute

in Melbourne, and Hang Tuah Medical

School in Surabaya, Indonesia.

Grants Over $200,000

14


Living & Breathing | Research | Cardiology Clinical Research Centre

Cardiology Clinical Research Centre

The Cardiology Clinical Research

Centre has been actively involved in

various leading edge heart technology

and research in Transcather Aortic

Valve Implantation (TAVI) since 2008

and is the Lead Investigational Site

across Australia and New Zealand for

the SOLACE Au Registry of the use of

the Edwards Sapien Device in patients

with high risk aortic stenosis.

Cardiology Clinical Research Centre

has completed more than 50 clinical

studies which are designed to capture

both the clinical and patient derived

benefits of life saving technologies and

therapies. The centre is recognised as

one of the top recruiters in device and

drug trials producing quality data and

efficient conduct of clinical trials. It has

become one of the few lead research

sites in Australia undertaking the role

of coordinating multi centre Ethics

submissions.

The main focus of our research is

the development of new therapies

for treating ischaemic heart disease,

structural heart disease and cardiac

rehabilitation. These areas represent

some of the most significant

contributors to cardiac morbidity and

mortality in the Australian context.

Unfortunately, heart disease continues

to be the single greatest burden of

disease in our community.


Centre is one the country’s leading

cardiac clinical trials unit. The Centre

conducts industry sponsored clinical

trials, academic research projects

and investigator initiated translational

research in the fields of interventional

cardiology, general cardiology and

cardiac rehabilitation.

The research team has a particular

interest in novel cardiac device

technology, innovative procedures,

new drug therapies, and outcome

based clinical registries. Early phase

trials, especially first-in-man studies,

are given priority.

The Centre has been at the forefront

of the introduction of transcatheter

heart valves, percutaneous valve

repair systems, new coronary

stent technologies and novel oral

anticoagulants into Australia. Our

team has been the national lead site

for a number of international and

national pivotal trials.

Our research has reduced mortality in

the treatment of valvular heart disease

in the (often elderly) high surgical risk

patient with aortic stenosis and mitral

regurgitation.

These are the most common heart

valve diseases affecting Australians.

New stent and imaging technologies

have made treating ischaemic heart

disease safer for patients. A number

of the new drugs have been shown

to reduce mortality and are safer

Professor Darren Walters

RESEARCH HEAD

24

Rese

arc

hers

15Cardiology Clinical Research Centre | Living & Breathing | Research

to use in the treatment of patient

with ischaemic heart disease and

arrhythmia.

The Transcatheter Valve Replacement

and Mitra Clip programs provide an

option for patients who are deemed

unsuitable for surgery, and provide

an alternative for high risk surgical

patients.

In most instances there are substantial

benefits to patients who consent to

be involved in our studies including

improving outcomes, a reduction

in mortality, morbidity and hospital

admissions, increased quality of life

and easing some of the economic

burden of their health care on the

community.

HIGHLIGHTS


Centre has been a stand out site for

studies in structural heart disease.

Professor Walters is the national lead

and principal investigator for the

SOLACE AU Registry of the use of

the Edwards SapienXT transcatheter

heart valves (TAVI) in patients with

intermediate to high risk aortic

stenosis.

In addition, the team has been the

leading enrolling site in the Medtronic

Corevalve Trial and the Boston

Scientific Reprise II (Lotus Valve) Trial.

Both studies involve new devices for

the catheter based replacement of the

aortic valve in patients with high risk

aortic stenosis.

This centre is also one of only three

in Australia involved in the study of

Percutaneous Mitral Valve Repair in

Australia using the Abbott Mitraclip

device for edge to edge repair of the

mitral valve in patients with severe

symptomatic mitral regurgitation.

These studies have been conducted in

collaboration with the Cardiac Surgical

Program.

In 2013, multi-centred international

clinical trials and national and local

investigator driven studies undertaken

in the centre included studies of

the renal denervation procedure,

bioabsorbable coronary stents,

new technologies in implantable

defibrillators and pacemakers, cardiac

magnetic resonance imaging of heart

valve repair systems, intravascular

ultrasound, fractional flow reserve,

optical coherence tomography,

novel ICT strategies for the cardiac

rehabilitation, as well as drug trials

for acute coronary syndrome and

coronary artery disease.

The centre is also continuously

collecting data for the

CONCORDANCE Registry

(Cooperative National Registry of

Acute Coronary Care Guideline

Adherence and Clinical Events), and

The Massachusetts General Hospital

Optical Coherence Tomography

Registry.

In 2013, the group published 27 papers

in peer-reviewed journals and were

authors on three book chapters.

There were more than 20 abstracts

accepted for presentation.

Numerous invited speaker faculty

presentation were undertaken by

group members at international

and national conferences including

ANZET 2013, the annual scientific

meeting of the Cardiac Society

of Australia and New Zealand,

Euro-PCR in Paris, Transcatheter

Coronary Therapeutics conference

in San Francisco, the London Valve

Meeting, the national meeting of the

society of Cardiothoracic surgeons,

the Singapore Live conference and

the Complex Coronary Therapies

conference in Japan.


A key publication for the year was

the first published clinical trial of TAVI

in Australia and New Zealand in the

International Journal of Cardiology.

AWARDS

QLD Innovation Award 2014

(iAward) for the MOTER platform for

management of IHD.

Health Round Table award for National

Grants Over

$1,700,000

16 Living & Breathing | Research |


Living & Breathing | Research | Cardiology Clinical Research Centre

Cardiology Clinical Research Centre (continued)

Excellence and Innovation, ‘Improving

health reimbursement through quality

coding’.

GRANTS


Centre has received over $1,700,000 in

industry support and grants, including

significant support for clinical trials.

RESEARCH STUDENTS


Centre had two PhD candidates and

three MPhil students during 2013.


The centre has extensive Australian

research collaborations including:

the University of Queensland; Griffith

University; eCSIRO; Royal Brisbane

and Women’s Hospital; Cairns

Hospital; Concord Hospital, NSW;

The Northern Hospital, Victoria;

Royal Adelaide Hospital; St Vincent’s

Hospital Victoria; St Vincent’s Hospital

NSW; Prince of Wales Hospital NSW;

Royal Melbourne Hospital NSW; Royal

North Shore Hospital NSW; John

Hunter New England NSW; Gosford

Hospital NSW; St George Hospital

NSW; George Institute NSW; Flinders

Medical Centre SA; South Australia

Health and Medical Research Institute

SA; Monash University, Monash Heart,

Victoria; and Royal Perth Hospital.

Internationally we collaborate with

industry and medical partners

including: Edwards Lifesciences USA;

Medtronic USA; Boston Scientific

USA; St. Jude Medical USA; Abbott

Vascular USA; Bayer Germany;

Servier France; Amgen; Biosense

Webster USA; Sanofi-Aventis France;

Biosensors; Reva Medical USA;

Vessix USA; Johnson and Johnson

USA; Centre of Outcomes Research,

University of Massachussetts Medical

School (UMMS) USA; Massachusetts

General Hospital; Harvard Medical

School USA; Barons Medical; Global

Genomics Group; Sanofi Aventis; Glaxo

Smith Klein; Janssen Cilag; Standford

University USA; Imperial College UK;

Oschner Clinic USA; and Siemens

Germany.

EDITORIAL POSITIONS

Prof Darren Walters, Associate Editor,

International Journal Cardiology.

Prof Darren Walters, Editorial Board,

Heart Lung and Circulation.

27Pap

ers

Publis

hed

Living & Breathing | Research 17

27Pap

ers

Publis

hed

Sascha Abdul-Rahman, research scientist

18 Living & Breathing | Research | Cardiac Electrophysiology

Cardiac Electrophysiology

The Cardiac Electrophysiology

research group consists of

electrophysiologists Dr Haris Haqqani

and Dr Russell Denman, EP Fellow

Dr Himabindu Samardhi, and cardiac

scientists Ms Colleen Taylor, Mr Daniel

Wright and Mr John Betts.

The increasing global epidemic

of heart failure and its associated

heart rhythm disturbances continue

to cause significant morbidity and

mortality, particularly related to stroke

and sudden death. An improved

understanding of the mechanisms of

these abnormal rhythms will lead to

the development of targeted therapies

for these common and devastating

clinical problems.

The group aims to contribute to

the mechanistic understanding of

various heart rhythm disorders and

to be involved in the development of

novel therapies for them. The focus

is particularly on potentially life-

threatening ventricular arrhythmias in

various at-risk patient cohorts.

Our work benefits patients through

the possibility of improved treatments

for the more complicated heart

rhythm disturbances and the

application of cutting edge technology

to develop better pacing and ablation

therapy.

HIGHLIGHTS

This year saw the continuation of

several multicentre clinical trials

of pacemaker and defibrillator

technology and the commencement

of the CAAN-AF trial looking at

AV node ablation in biventricular

defibrillator patients with atrial

fibrillation. The SmartTouch study

examining the use of contact force

sensing for atrial fibrillation ablation

concluded successfully without any

adverse events and with confirmation

of the utility of this new approach.

A protocol for a worldwide clinical

trial examining a new pacemaker lead

has been finalised with Dr Haqqani

being appointed the global co-

principal investigator. The existing

investigator initiated project examining

the mechanisms of idiopathic

outflow tract arrhythmias continued

recruitment.

New local and national collaborations

were established with the University

of Queensland and the University of

Melbourne.

The statewide research and

teaching forum Queensland Pacing

Electrophysiology and Group (QPEG)

was again convened throughout the

year with increased attendances

both in Brisbane and remotely

via teleconference. A proctoring

course for local and interstate

electrophysiologists on the use

Dr Haris Haqqani

RESEARCH HEAD

6Researchers

19Cardiac Electrophysiology | Living & Breathing | Research

of intracardiac echocardiography

during ventricular arrhythmia

ablations was successfully run in

the electrophysiology lab. Teaching

of medical students, residents,

registrars, fellows, scientists and

nurses continued throughout the year,

particularly in the weekly ECG and EP

meetings run by the group.


The group published 6 papers in

peer-reviewed journals in 2013 and

one book chapter. Eighteen invited

faculty presentations were delivered

at national and international meetings

and eight peer-reviewed abstracts

were also presented. Dr Haqqani was

an invited reviewer for seven journals

and graded abstracts for one national

cardiology meeting.

AWARDS

Dr Haqqani was again recognised

by the Heart Rhythm Journal as a

Remarkable Reviewer in 2013.


Within Queensland, the group

collaborates with the University of

Queensland and Princess Alexandra

Hospital. We also have research

relationships with the University of

Melbourne and Royal Melbourne

Hospital, and the University of

Pennsylvania in Philadelphia, United

States.

EDITORIAL POSITIONS

Dr Haqqani was an invited reviewer for

seven journals and graded abstracts

for one national cardiology meeting. 18Presentations



20 Living & Breathing | Research | Echocardiography Research Group

Echocardiography Research Group

Echocardiography remains the most

commonly used modality for imaging

patients with cardiac disorders. It

is widely available, is accurate and

provides prognostic information.

Cardiac anatomical and physiological

parameters are obtained using a

non-invasive, safe and well tolerated

technique. The echocardiography

laboratory at The Prince Charles

Hospital is actively involved in

both pre-clinical and clinical

research in the application of

existing echocardiographic imaging

techniques, as well as the expansion

and development of ultrasound

imaging in patients with heart disease.

HIGHLIGHTS

Research performed within the

Echocardiography Department

was presented at two international

meetings in 2013. The role of

echocardiography in ECMO was

presented (four posters and one oral

presentation) at the European ECMO

ELSO scientific meeting in Stockholm,

Sweden in May 2013.

Additionally, we had five abstracts

accepted at the American Society of

Echocardiography annual scientific

meeting, in Minneapolis, USA in June

2013. Two of these were selected as

finalists in the case report competition,

admirably presented by Darryl

Burstow.

There are currently numerous research

projects being performed within the

Echocardiography laboratory at The

Prince Charles Hospital.

These include expanding the use

of perflutren microsphere contrast

echocardiography, three dimensional

transoesophageal evaluation of

cardiac structures, and the role of

strain/myocardial mechanics in stress

echocardiography.

There is also active research in

the area of infective endocarditis,

especially cardiac device related

infective endocarditis (CDRIE).

Associate Professor Darryl Burstow

RESEARCH HEAD

10International Presentatio

ns

21Living & Breathing | Research


The group had four publications

in major journals, including the

International Journal of Cardiology

and the European Heart Journal

Cardiovascular Imaging.

Researchers from the group had five

abstracts at the American Society of

Echocardiography Annual Scientific

Meeting in June 2013, and four posters

and one oral at the European ECMO

ELSO scientific meeting in Stockholm,

Sweden in May 2013.

RESEARCH COLLABORATION

The researchers within the

Echocardiography department at

The Prince Charles Hospital work

closely and collaboratively with other

units both within the hospital, within

Queensland and also internationally.

Our collaborations include all cardiac

sub-specialities within The Prince

Charles Hospital, cardiac surgery,

adult intensive care unit and thoracic

medicine. We also work closely with

Innovative Cardiovascular Engineering

and Technology Laboratory (ICETLab)

and Critical Care Research group.

Collaborative research and education

links include the University of

Queensland, Queensland University of

Technology, Griffith University.

Internationally, there are collaborative

links with the University of

Washington, Seattle, Fujita Health

University, Japan and the Department

of Anaesthesiology and Intensive Care,

Philipps University Marburg, Germany.

There is also a collaborative research

and teaching link with Ochsner Heart

and Vascular Institute, New Orleans,

USA.

21Echocardiography Research Group | Living & Breathing | Research

“The most commonly used modality for imaging patients with cardiac disorders.”

22


Living & Breathing | Research | Cardiac Imaging Research Group

Cardiac Imaging Research Group

The Cardiac Imaging Research Group

(CIRG) undertakes clinical research

within the Richard Slaughter Centre

of Excellence in Cardiovascular MRI to

progress the development of magnetic

resonance imaging as a diagnostic

tool for congenital and acquired heart

disease.

The Prince Charles Hospital is the

largest cardiac MRI centre in Australia.

Cardiac CT research by CIRG aims to

improve patient safety through the

optimisation of acquisition protocols

and radiation reduction in patients

undergoing cardiac CT.

Research is also focused on reducing

cost and length-of-stay through the

investigation of cardiac CT in the

Emergency Department.

Our research focuses on accurate

measurements of cardiac function

for patients with congenital heart

disease, ischaemic heart disease,

cardiomyopathies and aortic disease;

understanding right heart function

at rest and stress in pulmonary

hypertension; and early detection of

myocardial fibrosis in hypertension.

The work benefits patients through

improved accuracy and reproducibility

of measurements of the left and

right heart, and quantitation of

valvular function, myocardial scar,

and fibrosis. This leads to better

informed treatment decisions based

on quantitative assessment of left

and right heart function, myocardial

viability prior to surgery, or functional

recovery after intervention (medical or

surgical).

We apply new MRI techniques to

better image the heart and great

vessels and provide more accurate

diagnoses.

HIGHLIGHTS

Through an international research

collaboration with Siemens Healthcare,

the CIRG was one of the first MRI

research groups in the world to have

access to advanced technology

enabling the capture of ultra-fast

images of the heart.

This ground-breaking technology

makes magnetic resonance imaging

during exercise clinically feasible by

maintaining spatial resolution and

reducing the image acquisition time

more than ten-fold (whole-heart

imaging in one breath hold, rather

than the usual ten breath holds).

In collaboration with the TPCH

Pulmonary Hypertension Program

and Griffith University, CIRG is using

this technology combined with an

MRI-compatible cycle ergometer, to

capture MR images of the heart while

the patient exercises inside the MRI

scanner.

Associate Professor Christian Hamilton-Craig

RESEARCH HEAD

10Researchers

“The largest Cardiac MRI centre in Australia”

23Cardiac Imaging Research Group | Living & Breathing | Research

Tour-de-France Champion and

Siemens Ambassador, Cadel Evans

opened the Exercise Cardiac MRI

research program in November 2013.

This event was broadcast

internationally, and received significant

media attention.

We completed the CT-COMPARE

randomised trial which showed that

cardiac CT angiography for chest

pain is superior to exercise stress

testing in an emergency department,

and provides significantly decreased

length of stay and reduced cost.

GRANTS

Members of the research group

received a Smart Futures Research

Fellowship Early Career Grant

(2012-2015) from the Queensland

Government, a main research grant

providing cash support for research

and fellows, and in-kind support from

UQ Centre for Advanced Imaging, and

a UQ Academic Title Holder Research

Grant which provided leveraged cash

support for research assistant and

ultra-high-field scanning at 7.0Tesla.

Additionally, the group received

a Capacity Grant from The Prince

Charles Hospital Foundation to build

research capacity within the Richard

Slaughter Centre of Excellence in

CVMRI.


Christian Hamilton-Craig was

invited to present at the Society of

Cardiovascular CT, National Heart

Institute of Malaysia, and World

Congress of Thoracic Imaging.

Wendy Strugnell was invited to

present at the 22nd international

meeting of the Section for Magnetic

Resonance Technologists of the

International Society for Magnetic

Resonance in Medicine (SMRT/ISMRM)

in Salt Lake City, and the 9th Annual

Meeting of the SMRT/ISMRM ANZ

Chapter in Sydney.

The group had four publications in

major international journals and 10

abstracts at national and international

meetings.

AWARDS

Wendy Strugnell received an

international award (the 2013 Crues

Kressel Award) from the Section for

Magnetic Resonance Technologists of

the International Society for Magnetic

Resonance in Medicine for outstanding

contributions to the education of MR

Technologists.

RESEARCH STUDENTS

During 2013 there were three PhD

students in the group, two with UQ

Centre for Advanced Imaging, and one

with the UQ School of Medicine.


Locally, CIRG has research

collaborations with the Centre for

Advanced Imaging at the University of

Queensland, Griffith University School

of Allied Health Sciences, and The

Prince Charles Hospital’s Cardiology

Program, Critical Care Research Group,

and Queensland Lung Transplant

Service.

Other Australian collaborations include

St Vincents Hospital, Melbourne and

University of Melbourne, the Charles

Perkins Centre for Imaging at the

University of Sydney.

International collaborations are

with Siemens Healthcare, Erlangan,

Germany, and the Cardiology and

Radiology Programs, University of

Washington, Seattle USA.

EDITORIAL POSITIONS

Associate Professor Christian

Hamilton-Craig holds editorial

positions with nine international

journals including Circulation:

Cardiovascular Imaging, the European

Heart Journal, and World Journal of

Cardiology.

In Vitro Human Heart Laboratory

Heart disease is the number one killer

in Australia.

Current drug treatments are often

inadequate and therefore new drug

targets are urgently needed.

The aim of the in vitro human heart

laboratory is to identify novel drug

targets that can be used for the

management and treatment of human

heart diseases including heart failure

and arrhythmias.

The laboratory is uniquely placed to

use live human beating heart samples

to understand disease processes, to

elucidate mechanisms and to identify

drug targets, directly in the human

heart.

Human heart disease carries a

significant and unacceptable burden in

the community.

Patients with heart failure are at

increased risk of sudden death due to

the occurrence of an arrhythmia.

The research carried out in the in

vitro human heart laboratory seeks

to identify chemicals, receptors,

biochemical pathways and specific

proteins that lead to progression of

heart failure and the occurrence of

arrhythmias.

It therefore may be possible to

identify new drug targets that can

more effectively manage and treat

heart disease.

In order to identify new drug targets

for patients, it is necessary to

understand disease processes.

The findings of the laboratory are

made available to the research and

clinical community so that they can

contribute to the development of

treatment strategies for patients.

HIGHLIGHTS

During 2013 the group had three major

studies published in the British Journal

of Pharmacology and PLoS One.

Noradrenaline is a naturally occurring

chemical in the body. It is released

from nerves and activates receptors

in the heart (beta-adrenoceptors) to

make the heart beat faster and harder

so that more blood can be pumped

around the body.

This effect is appropriate when we

are exercising since it allows more

oxygenated blood to be pumped to

vital organs.

However chronic activation of beta-

adrenoceptors in the context of heart

failure, or inappropriate activation

during a heart attack can cause

a progression of heart failure and

arrhythmias which can lead to death.

We used human heart tissues

to discover that enzymes called

phosphodiesterases (PDEs) can

Associate Professor Peter Molenaar

RESEARCH HEAD

Living & Breathing | Research | In Vitro Human Heart Laboratory24

4Rese

arc

hers

dampen the biochemical pathway

that noradrenaline uses to stimulate

the heart. Drugs called beta-blockers

can be used to protect the heart by

preventing noradrenaline from binding

to its beta-adrenoceptor (hence the

name beta-blocker).

One such beta-blocker, metoprolol,

blocks the access of noradrenaline

to the beta-adrenoceptor and has a

beneficial, protective effect on the

heart.

We found that metoprolol also works

by a novel mechanism by increasing

the activity of PDEs.

Thus the beta-blocker metoprolol is

likely to produce a protective effect

by at least two ways, by blocking

the beta-adrenoceptor to prevent

noradrenaline from binding to it and

also by increasing the activity of PDE

so that it dampens the harmful signals

initiated by noradrenaline that can

cause progression of heart failure and

can lead to arrhythmias and death.

The chemical noradrenaline works

by activating beta1-adrenoceptors

in human heart to causes

cardiostimulation. It works in a

highly organised way by binding to

highly specific regions of the beta1-

adrenoceptor.

Some time ago we discovered another

distinct, highly localised region of

the beta1-adrenoceptor that can be

activated, and called it the beta1L-

adrenoceptor binding site.

Activation of the beta1L-adrenoceptor

binding site stimulated the heart.

However the effect of chronic

stimulation of the beta1L-adrenoceptor

was not known.

In collaboration with Helen Kiriazis and

Xiao Jun Du of the Baker IDI Heart and

Diabetes Institute, Victoria, we found

that chronic activation is harmful to

the heart and makes the heart grow

inappropriately, a process known as

hypertrophy.

Therefore drugs that can block beta1L-

adrenoceptor could be useful to

prevent hypertrophy.

Our collaborators at the University of

Queensland, Professor Walter Thomas

and his team discovered novel bitter

taste receptors in human heart.

However it was not known what

they did to human heart function.

In an honours degree program, BSc

student Danielle Edwards and PhD

student Simon Foster investigated

what happens when the bitter taste

receptor is activated in human heart.

They found that some ligands that

activated the receptor caused severe

cardio-depression.

The next step in this project will be

to investigate which biochemical

pathways are responsible for this

effect and to develop blockers.

GRANTS

The group received a grant from The


to investigate the influence

of beta-blocker treatment on

phosphodiesterease 3A regulation in

human heart failure. We discovered

that the continued use of the beta-

blocker metoprolol in human heart

25In Vitro Human Heart Laboratory | Living & Breathing | Research

“Heart disease is the number one killer in Australia.”


In Vitro Human Heart Laboratory (Continued)

failure caused an increase in the

phosphodiesterese (PDE3) control of

harmful signalling by noradrenaline

which occurs naturally in the

human body. An increase in PDE3 is

protective in patients with heart failure

and patients who have arrhythmias.

In this grant we want to determine

how PDE3 increases its activity. If

we understand the mechanism, it

may provide a specific drug target

for patients with heart failure and

arrhythmias.


Researchers from the in-vitro human

heart laboratory had two publications

in the British Journal of Pharmacology

and one article in PLoS One 8.

RESEARCH STUDENTS

During 2013 the group had one PhD

candidate and one BSc Honours

student.


Locally, the group has research

relationships with the University

of Queensland and Queensland

University of Technology. Across

Australia we partner with Baker IDI

Heart & Diabetes Institute, Victoria;

University of Newcastle, NSW;

Canberra University, ACT; and Victor

Chang Research Institute, NSW.

Our international collaborations

include University of Cambridge, UK;

Dresden University of Technology,

Germany; University Medical Centre

Hamburg Eppendorf, Germany;

University of Oslo, Norway; and

University of Murcia, Spain.

EDITORIAL POSITIONS

Associate Professor Peter Molenaar is

an Associate Editor of Pharmacology

& Therapeutics, and Editor of

Naunyn-Schmiedeberg’s Archives of

Pharmacology.

3International Publications

Living & Breathing | Research | In Vitro Human Heart Laboratory26

27

Biomedical engineer Frank Nestler


28 Living & Breathing | Research | Christian Hamilton-Craig

Translating cutting edge technology

to direct patient benefits is the drive

behind Christian Hamilton-Craig’s

clinical research.

As a cardiologist, Christian finds new

cardiac imaging techniques essential

to getting the best overall results for

his patients.

‘I’m interested the application of new

technology to clinical practice,’ he

says. ‘How can we get better quality,

more reproducible images to answer

the questions? It’s translational

research. The feedback loop is

immediate.’

Christian’s research focuses on

magnetic resonance imaging and

ultrahigh field magnet 7 Tesla

scanning.

The Prince Charles Hospital has

Australia’s only exercise bike MRI,

opened by Tour de France champion

Cadel Evans who also participated in a

research study.

‘MRI is non-invasive, has no radiation

and is safe,’ he says. ‘We’re at the

absolute forefront globally for MRI.

‘That’s the legacy of Dr Richard

Slaughter who started the Centre

of Excellence in Cardiac Imaging in

2002, with the support of a Smart

State grant from the then-Beattie

government.’

That allowed TPCH to become the

biggest cardiac imaging centre in

Australasia and led to a state level

partnership between Queensland and

Washington State in the US. Christian

received the first grant from the

Queensland Washington Transpacific

agreement.

‘It’s a visionary grant because it’s

small money but has a big impact

for creating pathways for capacity

building,’ he says. ‘I’m still on staff at

the University of Washington.’

Strategic knowledge partnerships are

one of Christian’s passions. He’s been

building and maintaining informal

knowledge partnerships since he took

a year out of medical training to do his

research Honours at Cambridge.

He returned home and finished his

cardiology specialisation then a clinical

PhD which took him to the US and

Europe for one year each.

‘I learnt a lot about the business of

research and leveraging grants to build

capacity,’ he says. ‘Research must

have an other-focused motivation

and be collaborative and inclusive.

That doesn’t mean I don’t do the work

myself, but I bring people in to get

involved.’

Early in his career, Christian was

advised to have at least three projects

on the go so that there was always

something happening when other

projects inevitably stalled or slowed

down.

The key he’s found is to diversify

without being fragmented.

Despite being a self-described cliché

– balding middle-aged husband

and father of two with a golden

retriever and a white picket fence –

Christian’s focus is on forging new

paths and creating new knowledge.

His philosophy is to jump in and give

things a rip.

‘I could see all these new technologies

coming into medicine. How do you

know what’s real and what’s spin? You

have to test them out for yourself,’ he

says.

‘It’s important to engage positively

with industry. My research has been

enabled by early access to technology

in my clinical practice. That’s

immediately beneficial to my patients.’

Christian Hamilton-Craig


5

Living & Breathing | Research | Anaesthesia Research Group30

Anaesthesia Research Group

The Prince Charles Hospital

Anaesthesia Research group was

started as a departmental initiative in

order to maintain safety and quality

of anaesthetic practice through high

standard research driven by clinical

goals.

Despite being very recently

established, it has been a rapidly

growing group with involvement

in several clinical trials. Our initial

objective is to promote a positive

atmosphere for research activity in

our department such that research is

seen as an essential component of our

practice.

The priorities are to build adequate

research infrastructure and

attract funding by engaging in

multidisciplinary, national and

international collaborative research,

particularly in our area of expertise

and thereby creating a productive

research environment.

Our research helps us to improve and

review our anaesthetic practice to

provide exceptional patient care along

their surgical pathway.

The focus of our research is patient

related outcomes.

Currently our areas of interest

are pain management, ultrasound

guided regional blocks for pain

relief, perioperative medicine

including preoperative optimisation,

perioperative outcomes, pulmonary

hypertension and perioperative blood

management.

HIGHLIGHTS

In 2013, the major highlights included

the start of five investigator initiated

trials, collaboration with other

departments and hospitals for

multicentre trials and a pilot grant

from the Australian New Zealand

College of Anaesthetists (ANZCA).

Our group of anaesthetists, residents,

medical students, and perioperative

nursing staff have been actively

involved in these projects.

We are thankful to other units,

namely the Critical Care Research

Group, orthopaedic, general, and

cardiothoracic surgery, thoracic

medicine, and the Nursing Research

and Practice Development Centre for

their involvement and support of our

projects.

Inadequate treatment of postoperative

pain can be one of the main reasons

for persistent post-surgical pain.

A randomised double blind trial

was conducted to evaluate at the

efficacy of pregabalin and celecoxib in

managing pain following laparoscopic

cholecystectomy.

Dr Usha Gurunathan

RESEARCH HEAD

investigator initiated trials

31

This study received funding from The

Prince Charles Hospital Foundation.

A retrospective analysis of data from

all the hip and knee replacement

surgeries between 2006 and 2010

at The Prince Charles Hospital

was commenced to analyse the

relationship between body mass index

and adverse postoperative outcomes.

A pilot study was started to compare

the ability of waist circumference with

body mass index in predicting major

postoperative adverse outcomes

following non-cardiac surgeries.

The hypothesis is that body mass

index, being a ratio, is not an accurate

measure of obesity whereas waist

circumference is more reflective

of adiposity around viscera and

hence can more accurately predict

complications.

Orthopaedic surgeons use ketorolac

along with local anaesthetics for

infiltration into the joints following hip

and knee joint replacements.

The pharmacokinetics of ketorolac

following intramuscular and

intravenous routes has been well

studied.

However, there have been no previous

studies in humans on the kinetics of

ketorolac following intra-articular and

peri-articular infiltration.

Also the effect of such an infiltrated

ketorolac on renal function is

unknown.

Our study aims to assess the kinetics

of infiltrated ketorolac and the change

in renal parameters in the first 24

hours postoperative.

Elderly patients are more prone to

hypothermia because of increased

frailty, comorbidities, and impaired

thermoregulation with age. In the

current study, we aim to study the

changes to the body temperature

in patients undergoing hip fracture

surgery through the perioperative

course.

The secondary aims are to calculate

the prevalence of hypothermia

in the patients undergoing hip

fracture surgery arriving at the post

anaesthesia care unit and to evaluate

postoperative length of stay in the

recovery room as a consequence of

hypothermia.

Other highlights are our collaboration

with other national and international

hospitals for multicentre projects

including the RELIEF trial, the METS

study and the IronNOF study.

RELIEF trial (Restrictive versus Liberal

Fluid Therapy in Major Abdominal

Surgery): This project is initiated

by the Alfred Hospital Department

of Anaesthesia and Perioperative

Medicine and funded by an NHMRC

grant.

This project aims to identify optimal

fluid management strategy for major

abdominal surgery. The sample size

is 2800 patients and the project is

expected to run for three years.

The important aspect is that our TPCH

anaesthesia group will be running

an obesity substudy on all the 2800

participants.

This substudy is aimed as assessing

the effects of obesity, with various

body composition measures, on

the development of major septic

complications following major

abdominal surgery.

Measurement of Exercise Tolerance

for Surgery (METS) study and six-

minute walk test substudy: This is a

multicentre international prospective

cohort study on 1312 patients,

worldwide and initiated by Toronto

Hospital (Canada) and Alfred Hospital

(Australia).

The primary objective is to compare

preoperative cardiopulmonary exercise

testing to physicians’ subjective

assessments of functional capacity for

predicting postoperative 30-day death

or non-fatal myocardial infarction in

patients undergoing major elective

non-cardiac surgery.

Anaesthesia Research Group | Living & Breathing | Research

32


Living & Breathing | Research | Anaesthesia Research Group

IronNOF study: Ongoing discussions

with Fremantle Hospital, Western

Australia, for collaboration in their

study on assessing the benefits of

iron infusion on the elderly patients

undergoing hip fracture surgeries.

If found beneficial, this may lead to

changes in transfusion practices by

avoiding unnecessary transfusion in

this cohort of patients.

Dr Ivan Rapchuk is involved with

CCRG in the multicentre randomised

controlled superiority trial comparing

peripheral intravenous device

dressings and securement methods

(SAVE trial) to reduce the incidence

of catheter failure, which may

increase infection and reduce cost

effectiveness.


There were four publications in peer-

reviewed journals and five abstract/

poster presentations in 2013.

We presented a poster on the

retrospective analysis of the

relationship between body mass index

and complications following 1,666 total

knee replacements.

Through collaborative research,

abstracts were presented on the

safety of a mesenchymal-like

adherent stromal cell (PLX-PAD)

in a human model of pulmonary

arterial hypertension, feasibility and

effectiveness of establishing an ex vivo

lung perfusion service in Queensland,

point of care testing in cardiac surgery

patients and pilot study on the novel

approach to securing peripheral

arterial catheters.

Dr Faulke and Dr Natani were invited

national and international speakers

on perioperative blood management,

ROTEM, TAVI and perioperative

echocardiography.

GRANTS

ANZCA pilot grant 2013 of $5,000 was

awarded for the study on obesity and

major adverse outcomes following

non-cardiac surgeries.

AWARDS

Bronwyn Pearse received the

International Nurses Day awards for

Emerging Researcher and Clinical

Excellence.


The Anaesthetic Research Group has

local research collaborations with

the University of Queensland, Griffith

University’s AVATAR group & Centre

of Research Excellence in Nursing, and

across The Prince Charles, Princess

Alexandra and Redcliffe Hospitals.

Within Australia, the group

collaborates with Department of

Anaesthesia and Perioperative

Medicine, Alfred Health, Victoria, and

Fremantle and Royal Perth Hospital,

Western Australia.

The group has collaborative

relationship with the Applied Health

Research Centre, St.Michael’s Hospital,

Toronto, Canada.

Anaesthesia Research Group (Continued)


Griffith University biomedical engineering student Ned Granger

34


Living & Breathing | Research | Emergency Medicine Research Group

Emergency Medicine Research Group

The Emergency Medicine Research

Group was only formed in 2012

following the massive expansion of

Emergency Medical Services (EMS),

resulting from the government

initiative for TPCH to widen its scope

of practice. Its remit is to develop

research capacity within the EMS.

In line with the nature of emergency

medicine and our position as the

access point for hospital-based care,

our areas of interest span the whole

age spectrum (paediatrics-geriatrics)

plus a wide range of categories.

These include, but are not limited to,

critical care, cardiology, respiratory,

mental health, ultrasound, medical

education plus process and patient-

flow related topics.

Despite our relative youth, efforts are

beginning to pay off with the first

projects reaching the publication

stage, providing impetus for

ongoing growth that will be further

strengthened by the collaborations

we have built with other Emergency

Departments.

Every day around 200 patients of

all ages present to TPCH EMS with a

whole spectrum of undifferentiated

symptoms.

One of the challenges of emergency

medicine is to increase the speed,

efficiency and accuracy with which

we deliver care to these patients while

minimising harm.

Our research therefore not only

spans the spectrum of specialities

that ‘medicine’ traditionally divides

disease entities into but also looks at

the delivery of emergency care from a

number of different perspectives.

These include studies on the

symptoms that patients present with

rather than the final diagnosis and

how we investigate these with a view

to increasing future accuracy. Other

studies include audits/registries to

document compliance and uptake of

best practice, and improving patient

follow-up and flow, all within a rapidly

changing environment with high staff

turnover.

All our studies are aimed at improving

the quality of care but approach this

from a number of different angles.

These include increasing awareness

of and compliance with best practice

plus monitoring/improving systems

that cross-check the delivery of quality

care.

Those related to patient flow not

only aid compliance with government

targets with resulting improvement in

hospital reputation and function but

also decrease complications related to

extended stays within the ED. Studies

aimed at novel ways of doing things

Dr Frances Kinnear

RESEARCH HEAD

12Researchers

35Emergency Medicine Research Group | Living & Breathing | Research

include those aimed at preventing

deterioration through to those

investigating ways of reducing invasive

or potentially harmful diagnostic

and treatment strategies without

reductions in efficacy or accuracy.

This also has benefits in terms of

direct cost reductions but also indirect

benefits related to litigation and

reduced hospital stay.

Our studies benefit patients requiring

EMS on a number of levels. Process/

flow-related research may not seem

to benefit the individual but is actually

very important to overall function.

For example more rapid transit

through the EMS, when appropriately

applied, not only results in reduced

complications or negative outcomes

but also improved comfort and

satisfaction with the patient journey.

Advantages for patients related to

reduced use of invasive diagnostic or

treatment options are more intuitively

obvious, but their full impact is not

perhaps appreciated unless one has

been in the position of the patient or

carer.

For example, the ability of a novel

oxygen therapy to reduce intubation

in bronchiolitic children is being

investigated which is clearly desirable.

Less obvious are the benefits in

avoiding transport to a specialist

centre and reduction in the attendant

stress on the family.

HIGHLIGHTS

Although the Emergency Medicine

Research Group (EMRG) has only

been in existence for a few years it

continues to grow at a rapid pace.

In line with the strategic plan for its

development, collaborations have

been actively built in the early phases

both with the established specialties

already engaged in research at The

Prince Charles Hospital and with other

researchers within the emergency

medicine field throughout Queensland,

interstate and even internationally.

Dr Kinnear, the founder and director

of EMRG, is also deputy-chair of the

Queensland Emergency Research

Collaborative (QERC), a group of

multidisciplinary medical researchers

who aim to improve the quality and

impact of emergency health research

activities by supporting multi-centre

research. The group is currently

coordinating the involvement of a

number of emergency departments

from Queensland in several statewide

and national studies. A number of its

members also recently participated in

the Australian arm of an international

study.

In addition, having now satisfied

the criteria of having 15,000+

paediatric presentations per year and

a growing research profile, EMRG

has applied for membership of the

Steering Committee of the Paediatric

Research in Emergency Departments

International Collaborative (PREDICT).

The foundations thus constructed

provide a solid base for development

and the first projects are now nearing

the end of the research cycle.

Successful completion of projects not

only helps cement the relationships for

future collaborations but also begins

the process of growing the reputation

of EMRG as a developing research

group with the attendant influence

on attracting grant money for future

studies.

For example, a multisite study of

intramuscular Droperidol (DORM II)

has recently been completed, with

TPCH contributing over 10% of the

total patient enrolments.

The results of this trial have the

potential to change practice in an

area of emergency care that is fraught

with difficulties: namely, the sedation

of the patient with acute behavioural

disturbance. They are being prepared

for publication.

EMRG is also participating in a number

of ‘snapshot’ studies. These include an

international study to investigate the

characteristics of patients presenting

36


Living & Breathing | Research | Emergency Medicine Research Group

with shortness of breath and how

they are investigated, an Australia and

New Zealand study on the prevalence

of alcohol-related presentations to

the Emergency Department plus

a Queensland-wide study looking

into current practice in investigating

patients suspected of having a

subarachnoid haemorrhage.

Not only will the projects concerned

provide data to inform future studies

in these important fields but the

methodology employed and the

resulting collaborations are already

being used to kickstart other projects.

For example, through the role of

members of EMRG contributing to a

primary spontaneous pneumothorax

trial, including coordinating the

Queensland sites, several other trials

with the Centre for Clinical Research

in Emergency Medicine, Western

Australia, are now under development

in fields highly pertinent to the

practice of emergency medicine

– namely sepsis and pulmonary

thrombo-embolism.

The latter is to some extent being

based on the model being used in

the other snapshot studies and will

ultimately lead to further studies

designed to guide investigation

in patients suspected of having

this relatively rare but potentially

life threatening condition. These

developments also cement our

relationship with this important

group active in emergency medicine

research, as indeed do a number of

other collaborations mentioned herein.

Although, the focus up until this

point has been to develop research

capacity and culture by aligning

with established researchers, themes

are also now beginning to emerge

according to the interests of members

and their areas of expertise.

These include studies designed to

improve the delivery of care in the

emergency environment and to

minimise harm.

For example the group is participating

in a study run by the Australasian

College of Emergency Medicine

designed to investigate common

errors, in an Australia-wide airway

registry, plus a trial to investigate

the implementation of evidence-

based recommendations for the

management of patients with mild

traumatic brain injuries.

Another study looks at the

potential for lung ultrasound to help

differentiate heart failure from other

causes of breathlessness in the elderly

while there is also a paediatric trial

investigating the use of high flow nasal

cannula oxygen in bronchiolitis.

The former is a novel use of this

diagnostic modality in this country

while the latter is a relatively new

therapy being adopted into the

emergency environment for use in a

range of conditions.

Other studies relate to education, a

strong focus within the department.

Yet others are designed around the

experiences related to the rapid

growth of the department and in

particular the development of the

dedicated paediatric services both

from a staff and patient perspective.

These are obviously ongoing but

preliminary results have been

presented and prepared for

publication as indeed has work related

to the delivery of care at the opposite

end of the age spectrum, performed

with a view to developing quality

indicators for geriatric care.

All these projects look at the delivery

of quality care at the front line,

albeit from a number of different

perspectives.

Another exciting development within

EMRG is that, in line with the aim of

making research part of core business

of the multidisciplinary team in

Emergency, a grant has been secured

for a six-month project in collaboration

with the Nursing Research and

Practice Development Centre.

This will investigate the role of a

Emergency Medicine Research Group (Continued)

37Emergency Medicine Research Group | Living & Breathing | Research

Navigator Nurse in improving patient

flow and meeting NEAT targets in the

ED with the research nurses working

alongside the other Emergency staff,

thus embedding research within the

clinical process.

In summary, only a few short years

after its formation EMRG is now

poised at a critical and exciting

position in its journey as a developing

research group. It has strong working

relationships with a number of the

established specialties within TPCH

and has developed important links

within the emergency research field

active in Australia.

The first projects are now coming to

fruition and it is strongly positioned

to capitalise on these foundations,

a process greatly facilitated by the

employment of a research co-

ordinator, Dr Mike Watson in late 2013.


Dr Fran Kinnear and Dr Michelle

Davison presented the results of

their research projects (DORM II and

Paediatric High Flow for bronchiolitis)

at the Australasian College of

Emergency Medicine QLD Research

Symposium.

Two papers arising from the Improving

Quality of Care of Older People with

Cognitive Impairment in ED study

have been accepted in Academic

Emergency Medicine Journal to be

published in 2014.

The results of a recent simulation

study to improve staff confidence

and orientation in the new children’s

emergency service have been

submitted to Medical Teacher.

GRANTS

EMRG has received funding from

a number sources to continue its

research activities. The funding

received from Queensland Emergency

Medicine Research Foundation

(QEMRF) and University of Western

Australia has allowed the clinical trial

investigating the treatment of primary

pneumothorax to continue and also

provides operational support for the

trial across other sites in southern

Queensland.

Funding received from other

sources such as the Victorian Traffic

Accident Commission, QEMRF,

TPCH Foundation, AusHSI have

allowed the lung ultrasound trial,

paediatric high flow in bronchiolitis

trial, Navigator Nurse trial, and the

study implementing evidence-based

recommendations for patients with

mild traumatic brain injuries to

continue.


Within Queensland EMRG has ongoing

research collaborations with the Royal

Brisbane and Women’s, Mater and

Ipswich Hospitals, the University of


Technology, and Australian Catholic

University.

Interstate EMRG has ongoing

collaborations with the Centre for

Clinical Research in Emergency

Medicine (WA), Dept. Clinical

Pharmacology and Toxicology, Calvary

Mater Hospital (NSW), Joseph Epstein

Centre for Emergency Medicine

Research (VIC) and Central Clinical

School, Monash University (VIC).

Internationally, EMRG collaborates

with the London School of Tropical

Medicine & Hygiene (UK).

38


Living & Breathing | Research | Critical Care Research Group

Critical Care Research Group

The Critical Care Research Group

(CCRG) is a multidisciplinary team that

specialises in translational research in

areas relevant to critically ill patients.

By utilising a systematic approach

that combines basic science and

biomedical engineering research,

in vivo animal work and national

and multinational clinical studies in

critically ill patients, we aim to:

• Increase our understanding of the

many issues that face the critically ill

patient;

• Translate this new knowledge

regarding critically ill patients into new

or improved treatment modalities;

• Develop the quality and significance

of our research to become a nationally

and internationally recognised

research centre; and

• Facilitate inter-departmental and

international collaboration between

key specialties and opinion leaders

involved in acute care medicine.

Our research addresses most

importantly the diverse healthcare

needs of a critically ill patient.

This is dependent on the advanced

understanding of technology and its

clinical application, appreciation of

pathophysiology and understanding of

disease and smooth functioning of a

multidisciplinary team involved in the

care of these patients.

Our work continues to refine basic and

mechanical cardiorespiratory support

for critically ill patients.

Equally, our work in areas of

resuscitation and blood transfusion

has implications for care of any

acutely ill patient.

Allied health research in areas of

nutrition, physical therapy, speech

pathology and podiatry all ensure the

holistic research process, with the

critically ill patient always being at the

centre.

Our research also allows millions

to benefit from simple respiratory

support interventions in resource poor

settings demonstrating our quest for

innovation and our global relevance.

Clinically, a multidisciplinary team is

essential for best outcomes in the

sickest patients in the hospital.

Our research team mirrors the clinical

team with interdigitation of all the

relevant teams through research.

We believe that involving all these

teams acting synergistically, we can

improve clinical practice and patient

outcomes, reduce pain and morbidity

whilst shortening ICU and hospital

length of stays. In turn, we aim to

Professor John Fraser

RESEARCH HEAD

39Critical Care Research Group | Living & Breathing | Research

improve efficiency and reduce costs to

healthcare.

The patient is the ultimate beneficiary

as our research comprehensively

addresses many aspects of

management of a critically ill patient.

Better understanding of the disease

process and pathophysiological

sequelae of available treatments,

innovations driven by clinical needs

and cutting edge research into

advanced organ support techniques

and equal emphasis on qualitative

aspects of ICU all lead to better

outcomes for a critically ill patient.

HIGHLIGHTS

Our research activities in 2013 were

focused on multiple facets of intensive

care patient management.

The broad areas researched included

basic and advanced cardiorespiratory

management, advanced

extracorporeal cardiorespiratory

support and other mechanical

assist devices, effects of fluid

resuscitation and blood transfusion

in animal models of sepsis and

trauma, pathophysiology of thoracic

organ transplantation, neurological

injury during percutaneous cardiac

interventions, inhalational drug

delivery in critically ill, ex vivo lung

perfusion, facilitating communication

with the ventilated patient, nutrition

and physical therapy in the intensive

care unit (ICU) and qualitative

research into areas including

handover practices in ICU and clinical

information systems.

Our work in the above areas includes

both mechanistic and clinical research

undertaken within our science,

engineering and animal laboratories

and clinical areas.

CCRG was well represented with over

25 invited lecturers and around 45

high impact publications nationally

and internationally ensuring that

our work was presented in a timely

manner to the right target audience

facilitating further collaboration and

global participation.

This year saw the completion of the

three-year NHMRC funded ovine

ECMO model.

This study was developed to increase

our understanding of how artificial

lung support can be optimised to

allow even better outcomes in patients

who cannot be supported by normal

means.

To date, over 20 publications,

abstracts and presentations have

derived from this study with many

more pending. This study has elevated

the CCRG to the forefront of ECMO

research internationally.

2013 also saw the development of

an ovine model for acute traumatic

coagulopathy.

This model, supported by the

Australian Military, accurately mimics

the evolution of coagulation issues

following trauma and haemorrhage

and is an exciting new vehicle to

assess novel treatment modalities.

CCRG was awarded NHMRC funding

for investigating sepsis resuscitation in

an ovine model, commencing 2014.

Ongoing research in traumatic brain

injury, pharmacokinetics in critical

illness, transfusion related acute lung

injury continued throughout 2013.

Our ICET Lab was highly productive

in 2013 under Dr Shaun Gregory’s

watchful eye, both developing new

technology and testing existing

devices and systems in their state of

the art laboratory and in our animal

lab.

The year held incredible progress for

the BiVACOR total artificial heart with

the miniaturised device implanted in a

waking animal trial with our colleagues

at Texas Heart Institute, under Dr

Dan Timms’s leadership. Research

conducted by our engineering

team in 2013 not only allowed for

improvements on existing devices,

but also saw the development of a

number of new systems and devices,

Grants Over

$1,000,000

40


Living & Breathing | Research | Critical Care Research Group

with multiple successful animal

studies using two mechanical hearts

to replace the function of the native

biological heart.

CCRG not only initiated several

investigator led clinical studies but

also participated in numerous studies

conducted by other research groups.

Some of our key clinical research

areas included transfusion and

critical illness including point of

care coagulation testing; oxidative

stress in cardiac surgery; drug and

nutrient pharmacokinetics during

extracorporeal life support; respiratory

support in intubated and non-

intubated patients using high flow gas

delivery devices; neurological injuries

during transaortic valve implantation;

nutritional therapy during mechanical

cardiorespiratory support; speaking

valves in tracheotomised patients;

respiratory weaning; electric

impedance tomography in monitoring

respiratory support and progress in

ventilated patients; ECMO cannulae

securement.

These studies have potential to

significantly alter ICU practice. For

example, in an investigator driven

study examining securement methods

of ECMO cannulae, a medical grade

‘superglue’ was shown to have a

higher pull-out force than standard

practice and resulted in a practice

change in our ICU.

Furthermore, following microbiological

testing of dressings, it was revealed

that medical grade ‘superglue’ had

bacteriostatic properties and inhibited

bacteria migration at the insertion site

unlike Opsite (standard practice).

The physiological research we

conducted into HiFlo respiratory

devices in our clinical research led

us to believe that these devices

may assist children in resource poor

countries, such is their simplicity.

Working with Professor Kath Mailtand

in Kenya, we were awarded a $4.3

million grant from the Wellcome Trust

in 2013, and work begins in 2014 into

improving the outcomes in children

with pneumonia in our study across

four African countries.

We participated in a multi-centre

randomised controlled trial

coordinated by the ANZICS CTG to

determine best ventilator practice

in critically ill patients with acute

respiratory distress syndrome

(PHARLAP study).

We were also involved in a number

of studies to determine the ideal

securement method for peripherally

inserted intravascular devices.

Failure rates of these devices are

high and associated with pain to

the patient, worsened outcome and

increased cost.

The CCRG initiated these studies

through basic research which started

in the animal lab and has now grown

into three multi-centre randomised

controlled trials examining securement

access devices.

These studies aim to identify the best

securement methods in an attempt to

reduce device failure, infection rates

and costs to the healthcare system.

Our research also focuses on staff

practices such as clinical handover, as

it is clear that poor communication is

linked to adverse patient events.

Two studies were conducted in ICU

which resulted in implementation of

an electronic minimum dataset for

handover and education packages.

These studies aim to improve

communication practices and reduce

adverse events associated with

miscommunication.

Our work was appropriately

recognised nationally and

internationally and led to our active

involvement in various global

organisations such as Extracorporeal

Life Support Organisation (ELSO)

and the international ECMO network

which provide best practice guidelines

for optimal use of extracorporeal life

support therapies.

We now chair the Research and

Critical Care Research Group (Continued)

Protocols Chair for the entire Asia

Pacific region of ELSO – a fantastic

achievement and important task in this

rapidly evolving area of extracorporeal

life support.


Members of the group gave 30 invited

lectures and another 27 conference

presentations.

GRANTS

The group received 25 grants in

2013 totalling over $1M for the year,

including $450,000 awarded by The


and three-year funding of $400,000

per year from the National Health and

Medical Research Council.

AWARDS

Dr Kiran Shekar, as lead author,

received the Graeme Neilson

Best Published Paper Award for

‘Sequestration of drugs in the circuit

may lead to therapeutic failure

during extracorporeal membrane

oxygenation’ published in Critical Care

2012.

RESEARCH STUDENTS

CCRG had 27 higher degree research

students in 2013.


CCRG collaborates across Australia

with the University of Queensland;

Griffith University; Mater Hospital;

Queensland University of Technology;

CSIRO; Royal Brisbane and Women’s

Hospital; Princess Alexandra Hospital;

Holy Spirit Northside; Nambour

General Hospital; Austin Hospital,

Victoria; Royal North Shore Hospital,

NSW; Royal Adelaide Hospital, South

Australia; Australian Red Cross

Blood Service, NSW; RMIT University,

Victoria; Royal Children’s Hospital;

The University of New South Wales,

NSW; The Alfred Hospital; University

of Western Australia; The Children’s

Hospital, NSW; Royal Perth Hospital;

Royal Prince Alfred Hospital; and Royal

Adelaide Hospital.

International collaborations include

University of Malaya; Imperial College,

UK; Malmo University Hospital,

Sweden; National Cardiovascular

Centre Research Institute, Osaka,

Japan; Rayne Institute, King’s College,

London; Xian Hospital, Xian, China;

National Heart Hospital, Malaysia;

Ibaraki University, Japan; PREVOR,

France; University of Texas, USA; St

Michael’s Hospital, Canada; Bonfils

Blood Centre, University of Colorado,

USA; Helmholtz Institute, RWTH

Aachen University, Germany; Fisher

and Paykel Healthcare Ltd, Auckland,

New Zealand; Texas Heart Institute,

USA; National University Heart Centre,

Singapore; Universiti Teknologi

Malaysia, Johor Bahru, Malaysia; RWTH

Aachen University, Germany; Mbale

Hospital, Uganda; and Steve Biko

Hospital, South Africa.

EDITORIAL POSITIONS

Professor John Fraser is the Editor of

Intensive Care Medicine experimental

(ICMx), and Burns, and an Editorial

Board Member of Current Anaesthesia

and Critical Care.

45Publications

42


Living & Breathing | Research | Innovative Cardiovascular Engineering and Technology Lab

Innovative Cardiovascular Engineering and Technology Lab

It has been estimated that

approximately 277,700 Australians

were living with heart failure in 2008,

while only 71 heart transplants were

performed in the following year.

Clearly there are insufficient donors to

match the demand. Mechanical assist

devices are a proven therapy to treat

patients while they wait for a donor

heart to become available or as a

destination therapy.

The aim of the ICET Lab is to combat

cardiovascular disease by forming a

strong link between the clinic and the

engineering department.

Specific aims of the ICET Lab centre

on the development of new ventricular

assist device and artificial heart

technology, evaluation of clinical

monitoring tools and development

of systems to assist in new medical

device development and medical

training.

Research in the ICET Lab is focused on

the development of mechanical assist

devices through new pump design,

control techniques and implantation

procedures.

Research is also underway to reduce

postoperative complications such as

bleeding and stroke while improving

quality of life by making ergonomic

wearable components with built in

controllers that allow patients to

return to regular day to day activities

at home, rather than being confined to

a hospital bed.

We aim to improve patient lifespan

and quality of life through delivering

optimised alternatives to heart

transplantation.

We also focus on the evaluation of

various cardiovascular devices and

medical monitoring equipment using

our highly developed representation of

the heart and circulatory system.

HIGHLIGHTS

There were many highlights in 2013 in

the ICET Lab.

The BiVACOR total artificial heart

received over $2 Million in funding and

development moved to the world-

class facilities of the Texas Heart

Institute.

The device has since been miniaturised

and implanted in a waking animal

trial for over 80 hours of artificial

heart support, a record to date and

a demonstration of the amazing

progress made by all researchers

involved.

Meanwhile in Brisbane, researchers

implanted two devices normally used

to support the left side of the heart as

a total heart support system.

Professor John Fraser and Dr Shaun Gregory

RESEARCH HEADS

19Researchers

43Innovative Cardiovascular Engineering and Technology Lab | Living & Breathing | Research

The adjustments made to the system,

including banding the surgical grant

on the right-sided pump to reduce the

blood pressure delivered to the lungs,

demonstrated the capacity of these

clinically available systems to be used

in a wider range of patients.

The results were subsequently used

to adjust clinical practice when

implanting these devices.

New devices and systems were also

developed in the ICET Lab.

A patent application was submitted

for a new passive control system

which automatically adjusts

mechanical assist device flow rate

based on what the patient needs.

Another patent application was

submitted for a new implantation tool

for mechanical assist devices which

can dramatically reduce surgical time,

postoperative bleeding and other

postoperative complications.

The vast amount of research

completed in the ICET Lab through

2013 resulted in five publications,

17 presentations (6 international, 1

national and 10 local), a variety of

research awards and approximately

$230,000 in awarded competitive

research funding.

Shaun Gregory and Nicholas Greatrex

were awarded their PhDs, Kristin

Moser was awarded her Masters and

five ICET Lab students successfully

completed their undergraduate

engineering degrees.

The annual ICET Lab symposium,

which brings together national and

international researchers working

towards mechanical assist device

development, was a success with

tremendously positive feedback on

research to date and planning for

future research strategies.

GRANTS

Researchers in the ICET Lab received

nine New Investigator and Research

Equipment grants from The Prince

Charles Hospital Foundation totalling

over $195,000.


The ICET Lab team gave 17

presentations in Australia and

internationally and had five journal

articles published.

AWARDS

Michael Stevens received the Stenning

PhD Top up award, and the Michael

Ray Best Basic Science / Translational

Research Presentation award at The

Prince Charles Hospital research

forum.

Jo Phillip Pauls received the Stenning

Travel award.

Emma Schummy received the ABEC

Best student presentation award, the

DePuy Synthes Award for the best

final year project in the Bachelor

of Medical Engineering, and the

Engineers Australia JH Curtis Award

for the best overall project in the

Bachelor of Engineering.

BiVACOR Artificial Heart Funding

$2,000,000

“We aim to improve patient lifespan and quality of life.”

44


Living & Breathing | Research | Innovative Cardiovascular Engineering and Technology Lab

RESEARCH STUDENTS

During 2013, the ICET Lab had

seven PhD candidates, three Masters

students, and nine Honours students.

Dr Shaun Gregory and Dr Nicholas

Greatrex had their PhDs conferred.


The ICET Lab has Australian

partnerships with the University

of Queensland; Griffith University;


Princess Alexandra Hospital; University

of NSW; Austin Hospital, Melbourne;

Royal North Shore Hospital, NSW;

Royal Adelaide Hospital; Australian

Red Cross Blood Service, NSW; St

Vincent’s Hospital; The University

of New South Wales; University

of Western Australia; Royal Perth

Hospital; The Alfred Hospital; and

Royal Prince Alfred Hospital.

Internationally, the group collaborates

with Helmholtz Institute, Aachen,

Germany; Malmo University Hospital,

Sweden; National Cardiovascular

Centre Research Institute, Osaka,

Japan; Rayne Institute, King’s College,

London; Xian Hospital, Xian, China;

National Heart Hospital, Malaysia;

University of Malaysia; Ibaraki

University, Japan; PREVOR, France;

University of Texas, USA; St Michael’s

Hospital, Canada; Bonfils Blood

Centre, University of Colorado, USA;

Helmholtz Institute, RWTH Aachen

University, Germany; Fisher and

Paykel Healthcare Ltd, Auckland, New

Zealand; Texas Heart Institute, USA;

National University Heart Centre,

Singapore; and Universiti Teknologi

Malaysia, Johor Bahru, Malaysia.

Innovative Cardiovascular Engineering and Technology Lab (Continued)

17Presentations

45

Research scientist Luke Samson

46


Living & Breathing | Research | Cystic Fibrosis Research Group

Cystic Fibrosis Research Group

The Cystic Fibrosis research group

aims to improve fundamental

understanding of the complications

of cystic fibrosis as a multi-system

disease and to enhance all aspects

of care delivered to our patients and

improve clinical outcomes.

The group studies the

pathophysiology of CF focusing on

infection and inflammation of CF

airways using laboratory based in vitro

and in vivo (mouse model) techniques

to complement our clinical studies.

A major focus is to attract and retain

(and train) members of the CF

multi-disciplinary team in research

methods and principles ensuring

future sustainability of the CF research

program at The Prince Charles

Hospital. Increasing population of

adults with CF who are growing

older and a number of emerging

complications are now common place.

The team aims to better understand

how best to diagnose and manage

each of these complications and the

aetiology of manifestations such as an

increased risk of colonic cancer.

Cross-infection is now well established

and our research aims to improve

understanding of how this occurs and

what the implications of such infection

are to our patients. We are also

concentrating on the optimal model

of care to deliver to our patients in

the geography of Australia and the

growing numbers of adults with CF,

particularly through diagnosis and

treatment of lung infection, the major

cause of mortality and morbidity of

cystic fibrosis.

Clinical trials give patients the

opportunity to be involved in

international studies trialling

novel therapies and new device

technologies. Currently, 10 patients

have access to ivacaftor therapy

(for the 2nd most common CF gene,

G551D mutation). Research has also

led to delivery of safer care to patients

attending CF centres by changing

practice in outpatient clinics and in the

inpatient wards to reduce the risk of

cross-infection.

Research provides better

understanding of treatments offered

to our patients and the optimal way to

deliver them, for example preparation

for colonoscopy, effectiveness of

Telehealth, role of mentoring for

patients to enhance engagement and

adherence. Better diagnostic testing to

evaluate infection in CF allows better

early diagnosis of cross-infection and

better understanding of resistance to

antibiotics. Through research we have

improved understanding of modes

of cross-infection, which informs

evidence based infection control

policies and delivery of care at TPCH,

nationally and internationally.

Professor Scott Bell and Dr David Reid

RESEARCH HEADS

13Researchers

47Cystic Fibrosis Research Group | Living & Breathing | Research

HIGHLIGHTS

A major research theme over the

past 10 years for our group has

been to increase understanding of

the prevalence and clinical impact

of shared Pseudomonas infection

in patients with CF. A large national

study was published in the European

Respiratory Journal and reported the

largest such study performed to date.

Shared strain infection is common and

associated with increased treatment

requirements for patients with CF, the

two most common strains (AUST-01

and AUST-02) each cause infection in

~20% of Australians with CF.

This work was funded by the NHMRC

and our pilot work initially funded

by The Prince Charles Hospital

Foundation. Our group published an

important paper describing enhanced

methods for the diagnosis of shared

Pseudomonas strain infection using

state of the art technology and

will improve our ability to continue

our national Pseudomonas study

(longitudinal study to determine

clinical impact of these infections over

time).

We completed a clinical study to

determine how far and for how long

bacteria travel and remain viable after

coughing in adolescents and adults

with CF. This landmark study involved

a multi-disciplinary research team

of clinicians (adult and paediatric),

infection disease and infection

control experts, aerosol scientists and

molecular microbiologists.

This work was funded by the TPCH

Foundation and has just been

published in the journal Thorax with

an accompanying Editorial article

highlighting the importance of this

work. Cough aerosols travel much

further (4 metres) and remain airborne

much longer (45 minutes) than

previously thought and this has major

implications of the models of the

care we deliver. This work is likely to

influence care delivery internationally

and builds on our cough work

published over the past five years.

The lung of adults with CF is infected

with many different bacterial species,

which together comprise the lung

microbiome. In a novel study,

employing bacterial DNA sequencing

techniques, we were able to explore

the effect of intravenous antibiotics on

the CF lung microbiome.

In this study, performed in

collaboration with biostatisticians from

QIMR Berghofer Medical Research

Institute and to be published in the

European Respiratory Journal, we

demonstrate the apparent rapid

adaptation and resistance of infection

to antibiotic therapy. This work is of

great interest and has potential to

change opinions on how antibiotic

therapy should be delivered in the

future.

For several years we have been

interested in understanding the impact

of climate on infection in patients

with CF. Ramsay, Ranganathan and

Price published papers examining

bacterial infections common in CF

(Burkholderia cepacia complex,

Burkholderia pseudomallei and

Pseudomonas aeruginosa). It is

clear that risk of infection with some

bacteria is more common in certain

geographical and climatic conditions.

This work is ongoing and involves

collaborations with colleagues in

Darwin, Melbourne, Canberra and

internationally.

Several reviews and editorials

were published from our groups

highlighting important aspects of the

delivery of CF care in 2013 focusing on

the complications of CF in the older

patient, costs and modes of care and

the influence of regulators such as the

FDA and EMA on trial design. Original

work also reported improved ways

of supporting care for the patient

(utilising information technology

tools), involving collaborations with

colleagues at the RCH in Brisbane and

Tasmania.


The group had 16 papers published

during the year involving

collaborations with authors from 18

other research groups in Australia and

internationally.

Grants Over

$1,600,000

48


Living & Breathing | Research | Cystic Fibrosis Research Group

The NHMRC-funded national

Pseudomonas study, which

commenced in 2007 and has

generated more than 10 original

papers to date, published the key

clinical paper in the ERJ in 2013. Our

work on the longitudinal aspects of

this study will be completed in 2014.

Scott Bell presented plenary lectures

at the TSANZ Meeting (Darwin, April

2013) and Australasian CF Conference

(Auckland, August 2013). David Reid

and Scott Bell were invited speakers

at European CF Conference in Lisbon,

Portugal (June 2013). Scott Bell is the

Chair of the Organising Committee for

the ECFC Pulmonology/Immunology

Assembly (‘13 & ‘14).

Many members of the CF

Multidisciplinary Team presented

oral presentations and posters at

the TSANZ and Australasian CF

Conference in 2013.

GRANTS

The team was awarded more than

$1.6million grant support including -

Scholarships, Fellowships, Project and

Program grants (including NHMRC

and QCH Program Grant).

David Reid received the NHMRC

Practitioner Fellowship and

Queensland Health Health Research

Fellowship.

Scott Bell received the Queensland

Health Health Research Fellowship.

Kay Ramsay and Anna Tai each

received Cystic Fibrosis Australia

Postgraduate Scholarships in 2013,

and Kate Myslinski was awarded a

TPCH Foundation New Investigator

grant.

AWARDS

David Reid holds an NHMRC

Practitioner Fellowship and a

Queensland Health Health Research

Fellowship.

Scott Bell has a Queensland Health

Health Research Fellowship.

Dr Timothy Kidd was awarded The

University of Queensland Dean’s

Award for Research Higher Degree

Excellence.

Dr Anna Tai was awarded best poster

prizes at the TSANZ Conference

and RBWH Research Expo, and best

oral presentation at the Queensland

Children’s Medical Research Institute

Student Research day.

RESEARCH STUDENTS

Scott Bell supervises two PhD

candidates. David Reid supervises two

PhD candidates and one international

Honours student.


The Cystic Fibrosis research group

has multi-disciplinary collaborations in

Australia with Queensland Children’s

Medical Research Institute; University

of Queensland School of Population

Health; Queensland University of

Technology International Air Quality

Laboratory; QIMR-Berghofer Institute

of Medical Research; Clinical Genetics,

Royal Children’s Hospital, Brisbane;

Monash University, Vic; The Alfred

Hospital, Vic; Royal Prince Alfred

Hospital, NSW; Macquarie University,

NSW; Menzies School of Health

Research, NT; University of Tasmania;

and Child Telethon Institute, UWA.

Internationally, the group collaborates

with Johns Hopkins Medical Research

Institute, USA; University of North

Carolina at Chapel Hill, USA; Massey

University, Auckland, NZ; Otago

University, NZ; University of Toronto,

Canada; University of Swansea,

UK; International Pseudomonas

Consortium, Laval University, Canada

and Queen’s University, Belfast, UK;

Cambridge Medical Research Institute

and Sanger, Cambridge, UK; and Royal

Brompton Hospital, UK.

EDITORIAL POSITIONS

Professor Scott Bell is Editor-in-Chief

of the Journal of Cystic Fibrosis.

Cystic Fibrosis Research Group (Continued)

49

Laboratory technician Leanne Morrison

The goal of the Qld Lung Transplant

and Pulmonary Hypertension Research

Program is to improve patient

outcomes through innovation.

Our broad ranging research into

incurable lung diseases focuses on

basic science, translational and clinical

research.

Research is embedded within our

clinical programs, ensuring not only

that we deliver state-of-the-art care,

but also that our research questions

are highly relevant to human lung

disease.

It also means that we can rapidly

translate what we find in the

laboratory into improved outcomes for

our patients.

Bringing our clinicians and scientists

together in this way benefits everyone,

invigorates our clinical program, and

ensures that Queenslanders will always

have access to world class care.

Our program researches advanced

lung disease and lung transplantation,

which encompasses a range of lung

diseases for which there are no or few

therapeutic options available.

Our research aims to both understand

the biology of lung disease and to trial

potential new therapies.

As our research program is embedded

in the clinical program, our research

has direct clinical benefit for our

patients.

The clinical trial program trials new

therapies to stop the progression of

advanced lung disease and many

patients have had positive results.

The clinical trial program directly

trials new therapies for the benefit

of the patients, while studies from

the laboratory have identified the

increased presence of specific T cells

in poorly functioning lung transplants.

These results are then directly

translated into the clinical

management of the patients.

Finally, the basic research continues to

help us better understand the biology

of lung disease, and the transplanted

lung, so that in the future new

therapeutic targets can be identified.

HIGHLIGHTS

In 2013 our Research Program was

again recognised as a world leader.

We continue to be one of the top

contributors at The International

Society for Heart and Lung

Transplantation annual scientific

meeting and published 15 original

studies during the year.

In collaboration with the Australian

Centre for Ecogenomics (ACE, UQ),

Queensland Lung Transplant Service

Associate Professor Daniel Chambers

RESEARCH HEAD

50 Living & Breathing | Research | Queensland Lung Transplant Service

Support live saving research. Visit www.tpchfoundation.org.au

we established our Centre as the

world leader in the study of the lung

allograft microbiome and presented

our data in the Opening Plenary at the

International Society for Heart and

Lung Transplantation Annual Scientific

Meeting.

We remain the world’s largest centre

for stem cell therapy for lung disease

and in 2013 completed the world’s first

trial of stem cell therapy for idiopathic

pulmonary fibrosis. We also remain the

world’s largest recruiter of patients to

trials of new therapies for idiopathic

pulmonary fibrosis.

GRANTS

Our research program was supported

by approximately $700,000 in

competitive grant support in 2013,

including funding from the world’s

most prestigious funding source for

solid organ transplant research. In

addition, our clinical trials program

was supported by over $400,000

from industry.


Our group published a total of 15

original papers in 2013. We had

seven presentations, including

five oral presentations and one

talk in the Opening Plenary at the

International Society for Heart and

Lung Transplantation Annual Scientific

Meeting, again placing our program

amongst the top in the world.

RESEARCH STUDENTS

The program has four PhD students,

two MPhil, one MClin Pharm, and one

MBBS (Hons).


Our Australian collaborators include

Australian Centre for Ecogenomics;

University of Queensland; Griffith

University; QIMR-Berghofer; University

of Melbourne; Cell & Tissue Therapies

WA, Royal Perth Hospital; and Princess

Margaret Hospital, WA.

Internationally, we collaborate with

Harvard, Boston; United Therapeutics,

North Carolina; and University of

Vermont.

EDITORIAL POSITIONS

Associate Professor Dan Chambers is

a member of the Editorial Board of the

European Respiratory Journal.

51Queensland Lung Transplant Service | Living & Breathing | Research

“World’s largest lung disease cell therapy centre”

18Researchers

52 Living & Breathing | Research | University of Queensland Thoracic Research Centre

University of Queensland Thoracic Research Centre

The University of Queensland

Thoracic Research Centre (UQTRC)

is a longstanding research centre

that conducts research in partnership

with the University of Queensland

School of Medicine, and has a large

multidisciplinary team of clinicians,

scientists, students and researchers.

Clinical and translational research is

conducted in respiratory medicine

with the aim of improving lung health.

Research interests include lung

cancer, mesothelioma, chronic airways

diseases (such as chronic obstructive

pulmonary disease & asthma), sleep

medicine, pulmonary infection and

respiratory diseases caused by air

pollution.

The UQTRC is also developing

research strategies in population

based health and health service

improvement, as well as health

consumer participation approaches.

Our research program conducts

clinical and translational research

in airways diseases (such as lung

cancer, mesothelioma, asthma and

COPD) with a focus on methods

for prevention such as lifestyle

management and smoking cessation;

investigating innovations in early

detection, screening diagnostic

techniques using digital tomosynthesis

(DT), computed tomography (CT)

screening, volatile organic compounds

(VOCs) and bronchoscopy; genomics

and biomarkers to support the

discovery of personalised treatments;

medication repurposing; and, the

methods and processes through which

air pollution can lead to respiratory

diseases.

Our research aims at finding better

ways to detect and diagnose lung

cancer and other respiratory diseases

at an earlier stage in the disease

process, when identification can often

result in a boarder range of options for

treatment and an improved prognosis.

Our biomarker research program aims

to identify biomarkers in the human

genome, through blood or tissues

samples, that may lead also to more

personalised targeted treatments that

have a stronger ability to combat the

disease process and limit the damage

caused to the body.

In some cases, our work in the area

of trialling new diagnostic techniques

also aims at finding diagnostic tests

that are less invasive and more

comfortable for patients to experience,

for example a simple non-invasive

breath or blood sample may be more

comfortable and lower risk for patients

than tissue samples removed through

a formal procedure or surgery.

HIGHLIGHTS

This year we have two PhD, three

MBBS (Hons), and two BSc (Hons)

Professor Kwun Fong

RESEARCH HEAD

36

Rese

arc

hers

53University of Queensland Thoracic Research Centre | Living & Breathing | Research

students graduating; with one PhD,

two MPhil and four MBBS Honours

students commencing. Continuing

students include seven PhD students.

A large number of grant applications

were submitted to a range of funding

bodies. Training in grant writing and

project management was provided to

our laboratory staff and students and

as a result many have been successful

in obtaining scholarships or new

researcher grants.

The team developed a total of 21

publications this year (20 Journal

articles and one book chapter), with

an additional three under review or in

press; and over 20 presentations were

given at conferences or seminars, with

11 of these peer-reviewed abstracts

published. In addition one of our

MBBS (Hons) students (Joseph Burke)

has published a Cochrane protocol on

the use of glycopyrronium bromide

for chronic obstructive pulmonary

disease.

Professor Fong was the Co-Chair for

the 2013 IASLC World Lung Cancer

Conference in Sydney.

We have developed new

collaborations with a number of

internationally renowned researchers

including, for example, Dr Natthaya

Tribuhridet in Bangkok, Dr Lutz Krause

at QIMR, Dr Darryl Irwin at Sequenom,

and Dr Tim O’Meara at GE Healthcare.

We continued our collaboration with

The Cancer Genome Atlas (TCGA),

National Cancer Institute (USA)

for genomic analysis with samples

continuing to be submitted.

The National Health and Medical

Research Council Project Grant

studying methylation biomarkers

in lung cancer continues, as does

recruitment for the NHMRC-funded

AMAZES randomised controlled

trial of azithromycin in asthma, in

collaboration with John Hunter

Hospital. Our study continued during

the year using air-liquid interface

models for primary human bronchial

epithelial cells to test air pollution

exposure (ARC Discovery Grant

awarded with QUT collaborators).

PhD students in our group have

published in the fields of lung cancer,

expired breath analysis, and COPD.


The group published 21 journal articles

on air pollution, mesothelioma, LDCT

screening, genomics and biomarkers,

and tomosynthesis. We also published

one book chapter, one clinical

guideline, and one clinical protocol.

We have one journal article accepted

for publication (in press) and two

under review. Of particular note is the

book chapter in the World Allergy

Organization (WAO) White Book on

Allergy on the potential of genetics

in allergic diseases, and the clinical

guideline published in COPDX on the

management of chronic obstructive

pulmonary disease.

We also published 12 presentations

in peer-reviewed journals. Our PhD

students published in the fields of lung

cancer, expired breath analysis, and

COPD.

GRANTS

The UQTRC had $2,205,003 to

support research projects during

2013, including $489,559 in new

funding, $931,233 available in ongoing

grants from NHMRC and $784,211

available from other funding. New

Grants received included UQ/NHMRC

major equipment grant ($81,702),

two TPCHF experienced researcher

grants to support molecular studies

($199,379), three TPCHF new

researcher grants ($30,000), QH

Allied Health Thesis Assistance

Scheme ($26,126), and two TPCHF

Scholarships ($152,352).

AWARDS

Associate Professor Ian Yang received

The Prince Charles Hospital Award for

Excellence in Clinical Research 2013.

RESEARCH STUDENTS

The UQTRC currently has seven PhD

students; two MPhil Students; four

Grants Over

$2,200,000


54 Living & Breathing | Research | University of Queensland Thoracic Research Centre

MBBS (Hons) students, of these

one PhD, two MPhil and four MBBS

Honours students commenced

during 2013. During the year two PhD

students, three MBBS (Hons) and two

BSc (Hons) completed their studies.

A total of nine summer students also

attended the UQTRC during 2013.


The UQTRC has extensive research

collaborations in Queensland including

Royal Brisbane and Women’s Hospital;

Queensland Institute of Medical

Research - Berghofer Research

Institute; QFAB; CSIRO; Asia Pacific

Sequenom Bioscience; International

Air Quality Laboratory, Queensland

University of Technology; Lung and

Allergy Research Centre University

of Queensland/Princess Alexandra

Hospital; Royal Children’s Hospital,

Brisbane; Princess Alexandra Hospital;

Queensland Health Closing the Gap

initiative; Mater Hospital.

Nationally, we work with National

Health and Medical Research Council

(NHMRC) Centre for Research

Excellence for Asbestos Disease

Research; Bernie Banton Asbestos

Diseases Centre, University of Sydney;

Lowy Cancer Research Centre,

University of NSW; John Hunter

Hospital, Newcastle; NHMRC Centre

for Research Excellence National

Centre for Asbestos Related Disease, &

University of Western Australia; Alfred

Hospital, Victoria; Garvan Institute for

Medical Research; GE Healthcare; Sir

Charles Gairdner Hospital, and UWA;

The Clive and Vera Ramaciotti Centre

for Lung Cancer Research; Children’s

Cancer Research Centre, UNSW;

Peter MacCallum Cancer Centre, East

Melbourne; and Royal Perth & Princess

Margaret Hospitals, Perth.

Our international research

collaborations include Hamon Center

for Therapeutic Oncology Research,

Texas; National Cancer Institute,

NIH - NCI Cancer Genome Atlas

project; University of Southampton;

University of Hong Kong; University

of British Columbia and British

Columbian Cancer Agency (BCCA);

Brock University, Canada; Toronto

Lung Transplant program; Cancer

Services NSW Cancer Institute; Pan-

Canadian Early Detection of Lung

Cancer Study; Zhongshan Hospital &

Medical College of Fudan University

in Shanghai; VU University Medical

Centre, the Netherlands; Radbound

University Nijmegen, the Netherlands;

and Chulabhorn Hospital, Bangkok,

Thailand.

EDITORIAL POSITIONS

Professor Kwun Fong is an editor

and reviewer for several international

scientific and medical journals and

a grant reviewer for cancer councils,

NHMRC, and TPCH Foundation. He is

a higher degree thesis examiner for

seven Australian and international

universities.

Associate Professor Ian Yang is an

editor for five journals and reviewer for

10 international scientific journals. He

is a member of the Australian Satellite

of the Cochrane Airways Group.

University of Queensland Thoracic Research Centre (Continued)

55Core Thoracic Research Group | Living & Breathing | Research

The Core Thoracic Research Group

evaluates a range of thoracic disease

processes including pulmonary emboli,

pneumonia, pneumothorax, COPD, and

asthma.

Through our multidisciplinary

approach, we aim to improve service

to non-cystic fibrosis bronchiectasis

patients, and improve assessment

and management of a variety of lung

diseases leading to better outcomes

for our patients. Research allows

access to new therapies for our

patients.

HIGHLIGHTS

The group presented multiple

abstracts at the Thoracic Society of

Australia and New Zealand annual

meeting, including a presentation on

the new Thoracic Close Observation

Unit which has improved patient care.


The Core Thoracic Research Group

made nine presentations including

personalised care for COPD, the cost

of precise documentation, and the

impact of a clinical pharmacist in a

thoracic outpatient clinic.

GRANTS

Dietician Jenna Stonestreet received

a New Investigator grant from The


to study the influence of malnutrition

on clinical outcomes in patients

hospitalised with an infective

exacerbation of chronic obstructive

pulmonary disease.

AWARDS

Liz Pardede Presentation Prize 2013


We collaborate with the Queensland

University of Technology

Physiotherapy Department.

Core Thoracic Research Group

9Pre

sen

tati

on

s

Dr Philip Masel

RESEARCH HEAD


56 Living & Breathing | Research56 Living & Breathing | Research | James Walsh

If you want something done, ask a

busy person.

That seems to be the motto guiding

James Walsh’s life at the moment.

He has three kids, plays and coaches

basketball, and is currently involved

in no fewer than 15 research

projects, on top of his job as a senior

physiotherapist with Queensland’s

heart and lung transplant programs.

James’s PhD, which he completed

in 2013, was an examination of the

predictive factors of success in

pulmonary rehabilitation. He found

that patients who were weaker in the

quadriceps were more likely to benefit

from the rehabilitation program,

allowing physiotherapists to better

plan rehabilitation programs.

The study has been cited in numerous

other research projects around the

world.

‘I’m interested in the next stage of

the research looking at the response

to rehabilitation,’ he says. ‘Do people

who complete the program have

less healthcare needs, less doctor

visits, fewer emergency department

presentations?’

His personal research is currently

focused on frailty for transplant, the

tight balance between being both

sick enough and well enough for

transplantation, and post-transplant

recovery and exercise capacity.

Since 2000, James has worked

primarily with in the thoracic program,

but this year his role changed to

encompass both lung and heart

transplantation.

He’s keen to expand his research into

the physiotherapy needs of cardiac

patients.

‘I’m very passionate about research,’

he says. ‘I’ve got my own research

path and interests, but I also really like

to support young researchers develop

their projects.’

His own path has been fairly straight,

starting at the Royal Brisbane Hospital

as a graduate, and spending a year in

private practice before coming to The

Prince Charles Hospital.

‘I love exercise. I love the sport side of

physio, but this area is very interesting

and has captivated my attention for

more than a decade. It’s important

work.

‘It’s nice to see my patients get well

again,’ he says. ‘I meet them when

they’re sick and sometimes they get

sicker, but I watch them get well again

and get their life back.’

James Walsh




58 Living & Breathing | Research | Sleep Disorders Centre Research Group

Sleep Disorders Centre Research Group

The Sleep Disorders Centre Research

Group aims to heighten awareness

through clinical research of the

fundamental importance of sleep for

optimal health.

Our research includes studies into

insomnia, obstructive sleep apnoea,

and other causes of sleep disruption.

A key area of research is how to

improve the quality of life for patients

with neuromuscular disease (and

their carers) in the presence of these

disorders characterised by universal

increasing respiratory failure and

whether mouth-piece ventilation in

addition to standard care improves

quality of life.

The mouth-piece ventilation study

will allow patients with neuromuscular

disease and their carers to be better

informed about choices for assisted

ventilation as respiratory failure

progresses.

Concomitant insomnia occurs in

about 30% of patients with OSA.

Both disorders have the potential to

negatively impact on each other. There

is effective treatment available for

both conditions.

The CoMISA study will address

whether sequential treatment

improves outcomes in both these

common sleep disorders.

If the CoMISA study yields a positive

outcome, then combined treatment to

manage these common disorders may

become standard of care.

We are looking at whether treatment

of OSA with CPAP improves

cardiovascular outcomes through the

SAVE study.

The aim of the study is determine

whether the addition of CPAP to

standard cardiovascular risk factor

management lowers the incidence of

new cardiovascular events in patients

with established cardiovascular

disease and moderate to severe OSA.

This will mean that for patients with

cardiovascular disease, there will be

another treatment option to further

lower cardiovascular risk.

Sleep is a fundamental ingredient

for optimal health and tissue repair.

Recognizing and improving poor sleep

quality in hospitalized patients may

improve patient outcomes.

We are also interested in metrics

and novel technology, such as

accelerometry, to improve standards

and measurement of disrupted sleep,

including within the hospital setting.

The accelerometer study will provide

a better understanding of the role of

periodic leg movements in the genesis

of sleep disruption and daytime

dysfunction.

Deanne Curtin & Greg Jorgensen

RESEARCH HEAD

17Researchers


Sleep Disorders Centre Research Group | Living & Breathing | Research 59

HIGHLIGHTS

During 2013 we commenced an

NHMRC funded project grant looking

at co-morbid insomnia and sleep

apnoea (CoMISA study).

This multi-site study will examine in

a randomised control trial design,

the benefit of cognitive behavioural

therapy for insomnia in addition to

continuous positive airways pressure

(CPAP) for obstructive sleep apnoea

(OSA) in patients with both of these

sleep disorders.

Our group has previously

demonstrated the high prevalence

of both of these disorders coexisting

together. Both disorders have effective

treatment, but it is unknown whether

sequential treatment of the disorders

will be beneficial.

We have completed the recruitment

phase of the sleep apnoea

cardiovascular endpoints (SAVE)

study.

This is the largest intervention study

ever conducted in OSA.

It is a multi-national study with over

2800 participants enrolled.

The Cardiology, Cardiac Surgical

and Internal Medicine Programs all

contributed patients for this study.

TPCH recruited the third largest

number of patients from Australia and

New Zealand.

Follow up of patients will extend to

2016. Additionally TPCH was involved

with a cardiac MRI sub-study for

SAVE.

The research group is extremely

grateful for the fantastic support we

received from the Medical Imaging

Department at TPCH for this sub-

study.

We also commenced a quality of

life study examining the impact of

mouth-piece intervention in patients

with neuromuscular diseases and their

carers.

This study involves collaboration with

Institute of Sleep and Breathing in

Victoria and the Victorian Respiratory

Support Service.

Lynn Hoey, as part of her PhD

candidature, examined the impact

of sleep disturbance in hospitalised

patients.

This is an essential area of research

especially in an ageing population

undergoing more complex procedures

in hospital.

In order to define the relevance and

prevalence of this problem, robust and

easy to administer tools are required.

The initial part of Lynn’s PhD will focus

on what published methods to assess

sleep in hospitalised patients currently

exist.

The sleep scientific staff, in

conjunction with Medical Diagnostic

Technologies in Queensland MedTeQ

(University of Queensland), are

examining the utility of accelerometers

transmitting data wirelessly to more

accurately define the presence and

the consequence of periodic leg

movements (PLMs) in the genesis of

sleep disruption.

“Largest interventional study into obstructive sleep apnoea”

60 Living & Breathing | Research | Sleep Disorders Centre Research Group

Sleep Disorders Centre Research Group (Continued)


This research has the potential to

redefine the measurement of this

common cause of sleep disruption.

GRANTS

The Sleep Disorders Centre received

our first NHMRC Grant for the CoMISA

study which will provide $96,731

per year for 2013-2015 to fund the

research across TPCH & QUT for this

project.

This prestigious grant will allow our

group to examine this important

question.

Physiotherapist Kim Meden received a

Coopers Foundation Grant of $9,627

for the mouth-piece ventilation

study in patients with neuromuscular

disease.


We published our study of home

mechanical ventilation in the

European Respiratory Journal. This

study retrospectively examined the

indications and outcomes of patients

undertaking long term domiciliary

noninvasive ventilation in Australia and

New Zealand. It allowed comparison

to an earlier published study, the

Eurovent study, which examined

similar data in Europe.

AWARDS

Lynn Hoey received the Thoracic

Medicine Clinical Research Fellowship

($33,000) which allowed her to

commence her PhD candidature

examining sleep in hospitalised

patients

RESEARCH STUDENTS

The Sleep Disorders Centre Research

Group has one PhD candidate.


We collaborate with (CARRS Q)

Queensland University of Technology

& (MedTeQ) University of Queensland;

Institute of Sleep & Breathing, Victoria;

Adelaide Institute of Sleep Health,

South Australia; Flinders University,

South Australia; and The George

Institute for Global Health, Australia.

61

Eunike McGowan, critical care researcher

62 Living & Breathing | Research | Orthopaedic Research Group

Orthopaedic Research Group

The Orthopaedic Research Group

aims to improve the quality of life of

patients with osteoarthritis through

improved surgical outcomes and

prevention of disease progression.

Our research focus is primarily

on osteoarthritis and total joint

replacement surgery.

The aim of our osteoarthritis research

is to show the progression of disease.

Our clinical research has highlighted

the high standard of care delivered to

the patients presenting with fractured

femurs at TPCH.

More rational use of resources has

resulted as a consequence of research

showing that regular follow up of

patients with total hip replacement is

costly and unnecessary.

HIGHLIGHTS

The Orthopaedic Research Unit had a

busy 2013.

We published more than 23 peer-

reviewed papers on topics ranging

from pure basic science through to

clinical outcomes.

Our continuing publications from the

fractured neck of femur unit, known as

NO FEAR (Neck Of Femur Education,

Administration and Research),

highlight the excellent outcomes now

achieved from a dedicated unit.

The unit is covered by physicians, a

dedicated nursing and paramedical

staff, and the orthopaedic department.

The cooperation of the anaesthetic

department has led to a rapid

throughput of patients with minimal

delays to surgery.

Further research into the appropriate

peri-operative management of this

difficult group of patients is ongoing.

The unique collaboration with QUT &

tissue engineering research continues

to be fruitful.

Much progress has been made in

understanding the pathways of

osteoarthritis.

Though a cure is many years away, we

are gradually gaining insights into the

cellular mechanisms that contribute

to it.

Researchers come to theatre to see

procedures and tissue is collected

at surgery - clearly always with

appropriate consent.

Patients are very excited to know

that they can contribute to basic

science research and always excited

to hear that their stem cells have been

cultured in the laboratory.

Professor Ross Crawford

RESEARCH HEAD

20

Rese

arc

hers

63Orthopaedic Research Group | Living & Breathing | Research

Implant design remains an area

of focus for the unit and the

understanding of what may contribute

to fractures around implants has

greatly increased.

We believe that the overall incidence

of peri-prosthetic fractures nationwide

may be decreased by appropriate use

of implants.


In 2013 the Orthopaedic Research

Unit produced 23 referred journal

articles, eight presentations, six

abstract publications or conference

proceedings and one book chapter.

GRANTS

Orthopaedic Research received

funding from 15 grants in 2013.

RESEARCH STUDENTS

In 2013 Ortho Research had 16 PhD

students and eight masters students.


The group has significant

collaborations with Queensland

University of Technology; Holy Spirit

Northside Hospital; St Vincent’s

Hospital, Melbourne; Exeter Hip

Unit; Princess Elizabeth Orthopaedic

Centre, Royal Devon and Exeter

Hospital, Exeter UK; and Stryker Corp,

USA.

EDITORIAL POSITIONS

Professor Ross Crawford is an editor

of the Journal of Arthroplasty, and a

reviewer for ANZ Journal Surgery and

CORR.

Dr Bill Donnelly is an editor of the

Journal of Arthroplasty.

24Research Students


64

65

A chance news bulletin seen in an

Irish pub changed the course of Dan

Chambers’s life.

The young doctor was offered a

research job in Birmingham by

someone he didn’t know. He was

planning to turn it down until he saw

Professor John Ayres appear on the

news on the pub TV.

‘I realised he was famous and I should

take the job,’ Dan says. ‘He’s still

probably my main mentor.’

That serendipitous moment led Dan to

become a thoracic physician and then

complete his cystic fibrosis specialist

training at Papworth Hospital. ‘Who

should I bump into in the tea room

than my good friend from university

Peter Hopkins?’

A few years later Dan finished his

transplant speciality and now works

with Peter in the Queensland lung

transplant service at The Prince

Charles Hospital.

He previously worked in Perth where

a bone marrow project sparked his

interest in lung cell therapy.

The research has grown and The

Prince Charles Hospital is now the

world’s largest lung cell therapy

program as well as a world leader in

lung transplantation.

‘The most interesting part about

research is discovering new things

before someone else. I love using my

imagination to see things not as they

are conventionally seen,’ Dan says. ‘To

do research you have to understand

the dogma and the evidence of the

medicine – are they irrefutable or

shaky?’

His passion for discovering and

questioning the status quo has paid

off. Dan’s research has included

creating new treatments for lung

fibrosis and preventing transplanted

lung rejection.

He is collaborating with QIMR on a

world-first project, funded by NHMRC,

to transplant the patient’s own treated

T cells to manage lung failure.

Dan sees cell therapies as the future of

thoracic medicine, with the potential

to deliver a range of cell functions to

damaged cells.

He is also on the Pulmonary

Committee for the International

Society for Cell Therapy which is

working to regulate cell therapies

across the world.

‘A lot of problems are caused by

exhaustion of the person’s own cells,’

he says. ‘They can’t maintain the

organ and problems arise such as lung

fibrosis.

‘Cell therapy has got the capacity to

be far more effective,’ he says. ‘But

there’s a lot of unregulated treatment.

There’s a risk of harm to the patients

and the risk to the reputation of the

whole field.’

Dan Chambers

66


Living & Breathing | Research | Allied Health Ageing and Rehabilitation Research Group

Allied Health Ageing and Rehabilitation Research Group

The Allied Health Ageing and

Rehabilitation Research Group is a

collaborative comprising multiple

allied health disciplines including

occupational therapy, physiotherapy,

psychology, speech pathology, social

work, and nutrition and dietetics.

The group collaborates across many

of the medical programs at The Prince

Charles Hospital, other state and

national health services, and numerous

universities across the country and

internationally.

The group aims to use research

to improve health outcomes for

older patients and those individuals

requiring rehabilitation to maximise

participation and reduce long-term

disability.

Broadly speaking, allied health

research seeks to change the lives of

people living within our community

and this research group focuses

particularly on those requiring

rehabilitation services or who are

ageing.

Key areas of research include:

improving rehabilitation processes

and outcomes for survivors of

stroke; optimising the recovery

and functioning of the frail, aged

patient; and early identification and

management of vestibular dysfunction

(ie people who are dizzy, or fall) to

prevent hospitalisation and increase

life participation.

Members of the research group are

also key team members in clinical trials

research investigating drug therapies

for people with Alzheimer’s disease.

Research conducted by the group

seeks to improve assessment

techniques and treatment options

available to our patients.

It also enables us to identify the most

appropriate management for each

patient group, with a focus on right

patient, right place, and right time.

Research conducted by the Allied

Health Ageing and Rehabilitation

Research Group is driven by the

clinical practice with the aim of

improving the health outcomes of

our patients and reducing long-term

disability levels.

The patients are our research

participants and so they are part of

the research evidence as it evolves.

The research ensures patients

receive the most appropriate clinical

management for their condition, that

evidence based and cost effective

treatment options are available, and

that the staff treating them continue

to question their practice and improve

the service quality in a rigorous and

systematic way.

Dr Suzanne Kuys and Dr Petrea Cornwell

RESEARCH HEAD

18Researchers

67Allied Health Ageing and Rehabilitation Research Group | Living & Breathing | Research

HIGHLIGHTS


presented at state, national and

international conferences including the

International Association of Geriatrics

and Gerontology World Congress

of Gerontology and Geriatrics,

Canadian Association for Occupational

Therapists National Conference, and

the International Society for Posture

and Gait.

Dr Suzanne Kuys along with

collaborators from the University of

Queensland and University of Sydney

were awarded an NHMRC Project

Grant to investigate high intensity

treadmill training following stroke to

improve physical activity.

Speech pathologists Dr Petrea

Cornwell and Ann Finimore have

collaborated as associate investigators

with members of the Centre for

Clinical Research Excellence in

Aphasia Rehabilitation in a successful

NHMRC Partnership Grant comparing

two models of service delivery for

aphasia rehabilitation post stroke.

Dr Cornwell travelled to Beijing,

China, to meet with researchers at the

Chinese Academy of Sciences and

Peking University to discuss research

collaborations.

Late 2013 saw formation of the Centre

for Innovative Psychology Practice,

Education, and Research (CIPPER)

within the Metro North HHS as an

adjunct to the existing Allied Health

research groups at The Prince Charles

Hospital.

The centre draws upon a small, but

skilled, psychology workforce and

involves a number of training and

research partnerships with four

leading universities (Australian

Catholic University, Griffith University,

Queensland University of Technology,

and the University of Queensland).

CIPPER aims to be a centre of clinical

innovation and research excellence

in the field of medical psychology

with a number of small projects

already underway with the aim of

improving access to services, patient

experiences, and evidence-based

health care outcomes.



international peer-reviewed journal

during 2013. Members of the group

also made 54 presentations of

research findings at state, national and

international conferences.

Papers and presentations from the

researchers continue to build a

national and international profile for

The Prince Charles Hospital in the

areas of stroke and other acquired

brain injury, assessment and treatment

vestibular dysfunction, with growth in

the area of frailty.

GRANTS

IThe Allied Health Ageing and

Rehabilitation Research Group

received approximately $450,000

in research from local and national

competitive grant agencies including

National Health and Medical Research

Council, The Prince Charles Hospital

Foundation, and Queensland Health

(Health Practitioner Grants).

AWARDS

Dr R Mustaffa Kamal and Dr Emily

Nalder were awarded PhDs, and Mrs

Brooke Wadsworth was awarded her

MPhil.

RESEARCH STUDENTS


Rehabilitation Research Group has

four current Doctorate of Philosophy

candidates, and six current and two

new Master of Philosophy candidates

enrolled.

The candidates are drawn from a

range of allied health disciplines

(physiotherapy, speech pathology,

psychology) and enrolled through

various universities (University of


Sydney, and Griffith University).

Grants Over

$450,000

68 Living & Breathing | Research | Allied Health Ageing and Rehabilitation Research Group

Allied Health Ageing and Rehabilitation Research Group (Continued)


Research collaborations



extensive state-based research

collaborations, including with

Metro South, West Moreton, Gold

Coast Hospital and Health Services.

Collaborations also exist with

the following universities: Griffith

University, Australian Catholic

University, and University of

Queensland.



established national collaborations

with the Centre for Clinical Excellence

in Aphasia Rehabilitation, University of

Sydney, and NaCorr - Faculty of Health

Sciences ACU Research Centre (Stroke

& CV Disease), Australian Catholic

University.



developing international collaborations

with the Institute of Psychology,

Chinese Academy of Sciences

(Beijing, China), Baycrest, Rotman

Research Institute (Toronto, Canada)

and Department of Physical Therapy,

Universidade Federal de Minas Gerais,

Belo Horizonte MG, Brazil.

EDITORIAL POSITIONS

Dr Donna Pinsker is a Reviewer for

Oxford Handbook of Geropsychology.

Dr Petrea Cornwell is a member of

the Editorial Committee for Brain

Impairment.

54Presentations


54 Dr Stephanie Yerkovich, Chief Scientist, Qld Lung Transplant Program

70


Living & Breathing | Research | Allied Health Complex Chronic Disease Research Group

Allied Health Complex Chronic Disease Research Group

The Allied Health Complex Chronic

Disease Research Group is a

collaborative comprising multiple

allied health disciplines including:

occupational therapy, physiotherapy,

podiatry, speech pathology, social

work, and nutrition and dietetics.

The group collaborates across many

of the medical programs at The Prince

Charles Hospital, other state and

national health services, and numerous

universities across the country and

internationally.

The group aims to use research to

improve health outcomes for patients

with complex chronic diseases

through evaluating the effectiveness

of screening programs, best practice

interventions, and prevention of long-

term disability.

Broadly speaking allied health research

seeks to change the lives of people

living with chronic health conditions.

Key areas of research include: early

identification and management of foot

disease (ie foot ulcers and infections)

to prevent avoidable hospitalisation

and leg amputations; examining the

role of exercise in improving health

outcomes for heart and lung patients;

and maximising patients quality of

life through considering the impact

of chronic health conditions on varied

aspects of everyday living such as

mood, communication, eating and

drinking, memory, and participation in

basic life activities.

Research conducted by the group

seeks to improve in assessment

techniques and treatment options

available to our patients.

It also enables us to identify the most

appropriate management for each

patient group, with a focus on right

patient, right place, and right time.

Research conducted by the Allied

Health Complex Chronic Disease

Research Group occurs at ‘the coal-

face’ of health care. The patients are

our research participants and so they

are part of the research evidence as it

evolves.

The research ensures patients

receive the most appropriate clinical

management for their condition, that

evidence based and cost effective

treatment options are available, that

the staff treating them continue to

question their practice and improve

the service quality in a rigorous and

systematic way.

HIGHLIGHTS


presented at state, national and

international conferences including

the European Respiratory Society,

Australasian Cystic Fibrosis

Conferences, and the International

Dr Petrea Cornwell and Dr Suzanne Kuys

RESEARCH HEAD

18Researchers

71Allied Health Complex Chronic Disease Research Group | Living & Breathing | Research

Society of Heart and Lung

Transplantation Annual Scientific

Meeting.

James Walsh, a physiotherapy

researcher within the group, was

invited to present at the Thoracic

Society of Australia and New Zealand

on Exercise Rehabilitation Pre- and

Post-Lung Transplantation.

Peter Lazzarini, Senior Research

Fellow (Podiatry), was invited to

present at the International Diabetic

Foot Conference in Sydney.



international peer-reviewed journal

during 2013. Members of the group

also made 39 presentations of

research findings at state, national and

international conferences.

Papers and presentations from the

podiatry members of the group

continue to build a national and

international profile for The Prince

Charles Hospital as a leader in

research in foot disease.

While physiotherapy researchers

working in Heart and Lung continue to

build their national and international

profile as leaders in the field through

these publications and presentations.

GRANTS

The Allied Health Chronic Complex

Disease Research Group received

approximately $200,000 in research

from local and national competitive

grant agencies including The

Prince Charles Hospital Foundation,

Queensland Health (Health

Practitioner Grants), and Speech

Pathology Australia.

AWARDS

Tamara Milne, Ewan Kinnear, Helen

Martin, and Peter Lazzarini were

awarded Best Poster Presentation at

the Australasian Podiatry Conference.

RESEARCH STUDENTS


Disease Research Group has six

current and two new Doctorate of

Philosophy candidates, and two

new Masters of Research candidates

enrolled.

The candidates are drawn from a

range of allied health disciplines

(physiotherapy, speech pathology,

psychology and podiatry), and

enrolled through various universities

(University of Queensland, Queensland

University of Technology, James Cook

University, and Griffith University).



Disease Research Group has extensive

state-based research collaborations,

including with Metro South, Central

Queensland, West Moreton, Townsville,

Gold Coast, Cairns, and Sunshine

Coast Hospital and Health Services.

Grants Over

$200,000

“A collaborative comprising multiple allied health disciplines”

72


Living & Breathing | Research | Allied Health Complex Chronic Disease Research Group

Allied Health Complex Chronic Disease Research Group (Continued)

Collaborations also exist with

Griffith University, Australian

Catholic University, The University of

Queensland, James Cook University,

Queensland University of Technology,

and Central Queensland University.


Disease Research Group has

established national collaborations

with Royal Adelaide, Royal Melbourne,

Royal Prince Alfred, Royal Perth,

St Vincent’s, Western Melbourne,

Dandenong, Liverpool, and

Launceston Hospitals.

University collaborations have also

been made with the University of

Sydney, Monash University and

LaTrobe University.


Disease Research Group has ongoing

international collaborations with

the University of Arizona (USA),

University of West Indies (Jamaica),

University of Ottawa (Canada), Khon

Kaen (Thailand), and the University of

Manchester. (UK).

EDITORIAL POSITIONS

Peter Lazzarini was a Guest Editor

for the Journal of Foot and Ankle

Research.

32Publications


32 Dr Michelle Davison, Emergency Medicine Specialist

74 Living & Breathing | Research | Internal Medicine Dementia and Ortho Geriatrics Research Group

Internal Medicine Dementia and Ortho Geriatrics Research Group

The research group is comprised

of interdisciplinary clinicians with a

passion and interest in contributing

to research and creating and testing

innovative alternatives for better care

for their patients.

It combines the Internal Medicine

Dementia Research Unit (IMDRU) and

the Neck of Femur Education and

Research group (NOFEAR).

The goal of our research is to make

clinical care better.

Interdisciplinary clinically based

research is a driver for the

continuation of contemporary

evidenced based clinical practice.

Empowering clinician involvement in

research is also an enabler for personal

and professional skill development and

continuation of quality improvement

cycles.

The diverse research of IMDRU

and NOFEAR ranges from team

participation in research investigating

cutting edge treatment alternatives

and interdisciplinary therapeutic

interventions to facilitate, promote

and consolidate effective patient

outcomes.

The research groups are overseen

by the IMS Research Committee

which aims to provide a centre of

research excellence that drives clinical

improvement.

The committee provides leadership

and support to enable research and

provides overall governance of all

research undertaken within the wards

of the program to balance burden of

research with patient and ward clinical

activity.

The committee also functions to

provide peer review to researchers

and provide opportunity to optimise

research opportunity for all

interdisciplinary clinicians.

Internal Medicine research addresses

numerous health facets for the diverse

patient cohort to which the program

serves.

Specifically areas of health research

include: delirium; dementia, including

the use of recreational therapy to aid

behavioural and psychiatric symptoms;

frailty including goal setting, capacity

/decision making, pain and pressure

injuries; stroke and other acquired

brain injury; functional impairment

and treatment outcomes; falls; patient

flow and pathways, including from the

emergency department and returning

home; functional outcomes and

surgical predictors of hip fracture; and

oncology and cancer care.

Research undertaken in Internal

Dr Eamonn Eeles and Dr Chrys Pulle

RESEARCH HEAD

40

Researchers

Internal Medicine Dementia and Ortho Geriatrics Research Group | Living & Breathing | Research 75

Medicine and NOFEAR assists in

the search for a cure, diagnosis,

assessment of risks and the

opportunity for patients to trial

possible new treatments in the area of

cognitive decline, Alzheimer’s disease,

Clostridium Difficile and fractured

neck of femur. Research initiatives

and outcomes benefit the patient

journey and experience to ensure that

all patients have equitable access to

diagnostics, treatments, interventions

and follow-up.

Research undertaken in the Internal

Medicine and Dementia Research Unit

(IMDRU) assists in the improvement

of a diagnosis, the assessment of

risks and the opportunity for patients

to trial possible new treatments in

the area of cognitive decline and

Alzheimer’s disease.

Research initiatives and outcomes

benefit the patient journey and

experience to ensure that all patients

have equitable access to diagnostics,

treatments, interventions and follow-

up.

Further research projects have

demonstrated how pragmatically

focused action research studies

provide a platform for identifying,

implementing, evaluating and

publishing improvements to clinical

care within the scope of routine

clinical practice.

HIGHLIGHTS

In 2013 the Internal Medicine and

Dementia Research Unit (IMDRU)

has strived for the transference

of innovation and research to be

fostered in a culture of contemporary

interdisciplinary clinical practice.

The Neck of Femur Education &

Research (NOFEAR) collaborative

has established a growing

international research track record

in pragmatically focused studies

targeting multidisciplinary clinical care

improvements in patients with acute

hip fracture.

Sixteen new research studies were

commenced in 2013 to compliment

the ongoing work from previous years

and foster further research initiatives

in the coming years.

Dr Chrys Pulle won the Richard

Slaughter Research Award at The

Prince Charles Hospital 2013 Research

Forum with his presentation on

the impact of delirium on 12 month

mortality after hip fracture.

Dietician Jack Bell received the Health

Round Table Innovation Award in

the Stranded Patient stream for his

presentation on multidisciplinary

action research improves nutrition

related outcomes post acute hip

fracture.

Rebecca Ferrier was awarded a New

Investigator grant from The Prince

Charles Hospital Foundation to study

Grants Over

$700,000

“Creating and testing innovative alternatives for better care for their patients”

76


Living & Breathing | Research | Internal Medicine Dementia and Ortho Geriatrics Research Group

Internal Medicine Dementia and Ortho Geriatrics Research Group (Continued)

functional outcomes at discharge in

people with hip fracture, based on

fracture stability and fixation.

Dr Eamonn Eeles was appointed to

the Advisory Board of the Queensland

Brain Institute.

Other successes included

consolidation of systems and

processes to support the balance

of research in the clinical areas

and appropriate governance and

mentoring strategies, and successful

recruitment into large international

clinical drug trials for both Alzheimer’s

disease and Clostridium Difficile.

The group published 16 articles and

had 48 presentations (oral and poster)

in 2013.


The group had 16 publications and

multiple presentations.

GRANTS

Researchers in the group received five

grants including two SEED Innovation

Funding grants totalling $201,000, two

TPCH Foundation New Investigator

grants, and $498,938 from the Health

Innovation Fund.

AWARDS

Jack Bell received the Health Round

Table Innovation Awards and Dr

Chrys Pulle received an award for

his presentation at the 2013 TPCH

Research Forum.


Our research groups collaborate

with the University of Queensland;

Cambridge University Hospitals

NHS Foundation Trust, UK; Cardiff

University, United Kingdom; and

Ochsner Clinical School, Jefferson,

USA.

16New Studies Commenced

77Living & Breathing | Research

16 Brielle Parris, research scientist

78


Living & Breathing | Research | Oncology Services Research

The Oncology Services Research unit

is highly active in the participation of

studies focusing on new therapies in

the different stages of lung cancer.

We foster an ethos to undertake

clinical trials which will improve

treatments and outcomes for our

patients.

This has been reflected in major

changes to the treatment regimes our

patients now receive.

During 2013 we actively recruited

to seven pharmaceutical sponsored

& collaborative group studies and

followed patients in two studies which

had closed to recruitment.

The program participates in studies

that include the various stages of lung

cancer treatment (adjuvant through to

metastatic disease) and mesothelioma.

The program is involved in

international studies that investigate

novel therapies.

These therapies have changed

outcomes for patients, such as the

PROFILE 1014, study which included

Crizotinib for people with ALK

mutation positive lung cancer.

The program is also a leading

collaborator with the Australasian

Lung cancer Trials Group (ALTG).

The studies undertaken in the program

often involve treatments that are less

invasive as compared to standard

treatments, which can impact on their

quality of life.

The investigational drugs are often

well tolerated, and the patients

experience less side effects and

to a lesser extent. The treatments

potentially increase the patient’s

survival.

HIGHLIGHTS

Some of the highlights for the

program for 2013 include recruitment

to a number of international studies;

participating in practice changing

studies such as PROFILE 1014

(Crizotinib) and LUX-Lung 7 (Afatinib);

recruiting patients to the flagship

Australasian Lung Cancer Trials

Group (ALTG) NITRO study, which

investigates adding a Nitroglycerin

patch to standard chemotherapy

in the hope of improving patient

outcomes.

We also have an ongoing collaboration

with Dr Kwun Fong and his team on

the Mutation 177 study.


The team had one publication in Lung

Cancer and three presentations at

the World Lung Cancer Congress in

Sydney.

Oncology Services Research

Dr Brett Hughes

RESEARCH HEAD

79Oncology Services Research | Living & Breathing | Research

GRANTS

Our program received approximately

$100,000 in 2012 to support an

investigator driven clinical trial, which

has rolled over to 2013.

The program has also received

approximately $200,000 for

pharmaceutical sponsored clinical

trials.


The Oncology Service Research Group

collaborated with the UQ Thoracic

Research Centre, the Australasian

Lung cancer Trials Group (ALTG) in

New South Wales , and the National

Cancer Institute of Canada.

3Presentations

Grants Over

$300,000

80 Living & Breathing | Research | Nursing Research and Practice Development Centre

Nursing Research and Practice Development Centre

The TPCH Nursing Research and

Practice Development Centre

(NRPDC) is relatively new but

has had a significant impact on

nurse-led research hospital-wide,

generating grants, new projects

and collaborations, and resultant

publications.

Nursing research conducted via the

NRPDC ensures a rigorous approach

to both knowledge generation and

knowledge transfer.

This is achieved through systematic

research inquiry, evidence-based

knowledge application, evidence-

based intervention, implementation

and testing, and evaluation of

strategies that lead to measurable

health outcomes for Queenslanders.

Research undertaken via the NRPDC

is of particular value to TPCH patients

because the results can be rapidly

translated into clinical practice,

thereby achieving demonstrable

patient-focused outcomes in a

relatively short time frame.

The NRPDC houses a nurse-led

research team whose aim is to inspire,

support, and undertake quality

research within the hospital.

Its overall aim is to contribute to

improved clinical outcomes and

foster change through research and

encourage the implementation of

evidence-based practice regarding

patient care.

Our current research priority areas are:

falls injury prevention, pressure injury

prevention, cardiac care, thoracic care,

and emergency care.

HIGHLIGHTS

Two of the main research priorities for

the NRPDC are pressure injury and

falls injury prevention.

These research areas have been very

productive, and the research focus

on these helped TPCH to achieve an

excellent result in the 2013 Australian

Council of Healthcare Standards

Accreditation, with a total of seven

merits awarded in these two areas.

Research undertaken under the

auspice of the NRPDC has been

presented internationally, nationally

and locally.

A highlight of 2013 was the one-day

research seminar ‘Pressure Injury

and Falls Prevention: Research and

Implications for Practice’, which was

held at TPCH. Several TPCH research

projects were showcased to a large

audience from across the state.


Research via the NRPDC has resulted

in 13 publications in peer-reviewed

Professor Paul Fulbrook

RESEARCH HEAD

5Rese

arc

hers


journals, two peer-reviewed published

abstracts, 14 international conference

presentations, and six national

conference presentations.

GRANTS

NRPDC received a new investigator

grant and a small research equipment

grant from The Prince Charles Hospital

Foundation totalling $14,511; an

Australian Catholic University faculty

grant for $10,000, and a University of

Victoria faculty grant for $4,989.

We also received $74,000 from

the Australian Centre for Health

Services Innovation for a study in the

emergency department to implement

and evaluate a new ‘Navigator’ nursing

role to improve timely delivery of

patient care.

RESEARCH STUDENTS

During 2013, five PhD students, one

MPhil student, three Master of Nursing

(Research) students, and one Honours

student were supervised via the

NRPDC.


We collaborate in Australia with

the Faculty of Health Sciences,


Australian Catholic University;

School of Public Health, James Cook

University; Monash Health, Victoria;

and Nursing Research Institute, St

Vincent’s Hospital, Sydney.

Internationally, we work with Victoria

University, Wellington New Zealand,

and University of Witswatersrand,

South Africa.

EDITORIAL POSITIONS

Paul Fulbrook is the editor for one

peer-reviewed journal, and on the

editorial board of another. He is also a

journal referee for five nursing journals.

Melanie Jessup is a journal referee for

seven nursing journals and Sandra

Miles is referee for one.

81Nursing Research and Practice Development Centre | Living & Breathing | Research

14International Presentations


It’s internationally known for

progressive heart surgery, lung cancer

treatment and transplantation, but

perhaps The Prince Charles Hospital

could also lay claim to the largest

number of young PhDs per capita.

Dr Felicia Goh is certainly doing her

part in that area. At only 31, she’s

already five years post PhD.

Four of those post-doctoral years have

been in the University of Queensland

Thoracic Research Centre, a research

powerhouse hidden in an old orange

brick building at The Prince Charles

Hospital.

Felicia’s research currently focuses

on the connection between ageing,

lung cancer and chronic obstructive

pulmonary disease with Associate

Professor Ian Yang, and a study of the

similarities between neuroendocrine

cancers with Professor Kwun Fong.

That’s not the subject of her PhD

though.

Felicia’s original research interest

was how the immune system detects

parasite products, as a joint PhD

student with the CSIRO and UQ

Institute of Molecular Biosciences.

‘I was working with livestock industries

looking at parasites in sheep and

cattle,’ she says. ‘Most of the work was

in mouse models.’

Once she finished studying, Felicia

decided she needed to work more

closely with humans.

She found a good fit between the skills

she picked up during her PhD and the

needs of the UQTRC.

‘I wanted something more clinically

based. It’s good to have direct access

to patient samples,’ she says. ‘The

research is directly relevant.’

Felicia has always been interested in

science and human disease.

‘I find it interesting how the body

deals with disease, whether through

genetics, environmental factors or

pathogens.’

Felicia Goh

82 Living & Breathing | Research | Felicia Goh


84


Living & Breathing | Research | Grants

Project Chief Investigator

TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

MITRA CLIP Darren Walters Abbott Vascular No payments received in 2013

Industry sponsored

Mitra Clip MRI ECHO Study

Christian Hamilton-Craig, Niranjan Gaikwad, Darren Walters

Abbott Vascular $11,000.00 Industry sponsored

James Walsh Allied Health Professionals Office of Queensland

$37,905.00 $37,905.00 2013 Scholarship

Nicole Bellett Allied Health Professionals Office of Queensland

$37,905.00 $37,905.00 2013 Scholarship

A fundamental study into the role of the organic fraction on the toxicity of combustion generated airborne particles

Ristovski Ian Yang Australian Research Council

$390,000.00 $130,000.00 2012-2014 Australian Research Council Discovery Grant

Hypoxia-mimicking Bio-scaffold for Skeleton Regeneration

Yin Xiao R Crawford Australian Research Council Discovery - Projects

$271,691.00 $107,843.00 2012-2014

The development of new scaffolds for bone repair comprising polycaprolactone and strontium-substituted bioactive glasses

Mia Woodruff R Crawford Australian Research Council Linkage - Projects

$366,214.00 $100,779.00 2012-2014

The development of new scaffolds for bone repair comprising polycaprolactone and strontium-substituted bioactive glasses

Mia Woodruff R Crawford Australian Research Council Linkage - Projects

$366,214.00 $50,000.00 2012-2014

Bone Tissue Engineering using Innovative Tubular Dual-layered Nanofiber Meshes

D Hutmacher R Crawford Australian Research Council Linkage Projects with APAI or APDI components

$94,214.00 $94,214.00 2011-2013

Bone Tissue Engineering using Innovative Tubular Dual-layered Nanofiber Meshes

D Hutmacher, R Crawford Australian Research Council Linkage Projects with APAI or APDI components

$390,108.00 $47,522.00 2011-2013

Implementation, evaluation and efficacy of a Navigator Nurse with regard to supporting flow in the ED Department (NAVIGATOR)

Paul Fulbrook Fran Kinnear AusHSI $75,000.00 2014 project grant

Grants

85Grants | Living & Breathing | Research


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Implementation and evaluation of an ED Navigator role to improve timely delivery of care

Paul Fulbrook F Kinnear, M Jessup

AusHSI $74,000.00 $74,000.00 2014 Health Services Innovation

A double blind trial of the application of 0.2% glyceryl trinitrate ointment for the healing of chronic venous

R Lord P Fulbrook, D Williams, S Miles, F Kinnear, J Rowland

Australian Catholic University

$10,000.00 $10,000.00 2014 Faculty Grant

Organisational aspects of peri-operative care; Does Team case volume affect outcomes in cardiac surgery?

Daniel Mullany John Fraser, Ian Smith, Peter Tesar

Australian Centre for Health Services Innovation

$58,100.00 2013 Stimulus Grant

Usha Gurunathan Usha Gurunathan

Australian NewZealand College of Anesthesiologists

$5,000.00 $5,000.00 2013-2014 Pilot grant

SMART TOUCH Harris Haqqani Biosense Webster

$16,311.00 Industry sponsored

BEACON 2 Darren Walters Biosensors $4,950.00 Industry sponsored

LEADERS FREE Darren Walters, Chris Raffel

Biosensors Europe SA/CERC


EVOLVE I Darren Walters, Chris Raffel

Boston Scientific $7,800.00 Industry sponsored

EVOLVE II Darren Walters, Chris Raffel


EVOLVE II QCA Darren Walters, Chris Raffel


REPRISE II Darren Walters Boston Scientific $279,265.00 Industry sponsored

INGEVITY Russell Denman Boston Scientific $5,000.00 Industry sponsored

PLATINUM WORKHORSE

Darren Walters Boston Scientific $2,595.00 Industry sponsored

REDUCE HTN Darren Walters Boston Scientific $92,879.00 Industry sponsored

COHEREX Darren Walters Coherex $21,400.00 Industry sponsored

Detection of treatment-responsive lung cancer mutations.

Kwun Fong Kwun Fong, Rayleen Bowman, Duhig, Clarke

Cancer Council Queensland

$181,900.00 $90,590.00 2012-2013 Project

Molecular mechanism of carbapenem resistance in Pseudomonas aeruginosa from patients with cysitc fibrosis

Anna Tai Scott Bell CF Australia Postgraduate Scholarship

$15,000.00 $5,000.00 2013-2015 Project grant

Adaptive and innate immunity in children with bronchiectasis

Anne Chang Yerkovich ST Channel 7 Children’s Research Foundation

$75,000.00 $37,500.00 2013 Project

86



TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

CONCORDANCE Darren Walters Concord $27,340.00 Industry sponsored

Role of the mouthpiece non-invasive ventilation in neuromuscular disease

Kim Meden James Douglas, Petrea Cornwell

Coopers Brewery Foundation

$9,626.88 $4,500.00 2013-2014 Project

eCSIRO CAP mobile phone based cardiac rehabilitation (2010-2013)

Darren Walters CSIRO $250,000.00 Project

Clinical Consortium of Genomics data produced by Pseudomonas International Consortium

Scott Bell Cystic Fibrosis Canada

$Can750000 $250,000.00 2013-2015 Project grant

Non-Invasive Cardiac Imaging

C Hamilton-Craig C Hamilton-Craig

DEEDI $180,000.00 $60,000.00 2012-2015 Early Career Grant

CHORuS-II - Coagulation, Haemorrhage and Oxygenation in Resuscitation of Severe trauma - Phase II

John Fraser l Elissa Milford, Yoke Lin Fung, John-Paul Tung, Kiran Shekar, Natasha Van Zy

Defence Health Foundation

$84,300.00 2013-2014 Booster Grant

Goal planning in community rehabilitation settings exploration of the process and the relationship between client-centredness, contextual factors and outcomes.

Emmah Doig Petrea Cornwell Division of Rehabilitation CRWP Research & Development Grants

$30,886.00 $15,443.00 2013-2014 Project

Mood disturbance following acute MI (2010-2013)

Darren Walters DOHA $250,000.00

SOLACE Darren Walters Edwards $13,916.00 Industry sponsored

Cross sectional study of lower Airway infection, nasopharyngeal carriage and adaptive immunity in children immunised with synflorix

Anne Chang ST Yerkovich GSK $436,527.00 $110,000.00 2011-2013 Project

Accelerated Transient Attack Pathways – TIA, Seizure, Syncope and Falls

Jeffrey Rowland, Rohan Grimley, Elizabeth Whiting, Kevin Clark, Hayley Middleton

Health Innovation Fund

$498, 938

How transmissible is influenza by the airborne route?

Graham Johnson Scott Bell Institute of Health and Biomedical Innovation

$30,000.00 $15,000.00 2013-2014 Project grant

Endothelin Blockade in Ex-vivo lung perfusion

John Fraser Ryan Watts, Kimble Dunster

Intensive Care Foundation

$24,998.05 2014

OPTIMA Darren Walters Investigator Driven

$11,000.00

IIS-141 Harris Haqqani Johnson and Johnson



87


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Elastin integrity and the development of aortic aneurysm

Malcolm West, Maria Nataatmadja

Medical Advances Without Animals Trust Research Grant Scheme

$30,000.00 2012-13

ATTAIN PERFORMA Russell Denman Medtronic $15,862.00 Industry sponsored

PROTECT PCI Darren Walters Medtronic $1,389.00 Industry sponsored

COREVALVE Darren Walters Medtronic $67,734.00 Industry sponsored

Educational Grant Russell Denman Medtronic $45,000.00 Industry sponsored

Delirium Pathway for Hospital in the Home (HITH)

Eamonn Eeles, Kym Tattam, Kirstie Hastie

Metro North $105,000.00 SEED Innovation Funding

Improving care of older orthopaedic patients

Chrys Pulle, Jack Bell, Margaret Cahill

Metro North $96,000.00 2013-2014 SEED Innovation Funding

Personalised care for COPD - the COPD Snapshot

Ian Yang Ian Yang, Rayleen Bowman,

Metro North Hospital and Health Service

$30,537.00 $15,685.00 2012-2013 SEED Innovation project

Resuscitation in Endotoxaemic Shock - Understanding Sepsis (RESUS)

John Fraser Kiran Shekar, Yoke Lin Fung, John-Paul Tung

National Health and Medical Research Council

$1,240,880.00 2014 - 2016

Project Grant

Giving an adult life after Fontan surgery to those with the most severe congenital heart conditions

Yves d'Udekem Dorothy Radford


$ 1, 250,181 2013-2018 Partnership Projects

National Health and Medical Research Council 2013 application: APP1063041 Clinical trial of coronary artery calcification scoring in COPD

Ian Yang, Darren Walters, Christian Hamilton-Craig


$357,111.00

Novel therapies for bronchiectasis

Scott Bell National Health and Medical Research Council

$441,367.00 $147,122.00 2011-2013 Project grant

Identification of the mechanisms of liver fibrinogenesis and the detection and prediction of clinical outcomes in paediatric cholestatic liver disease

GA Ramm David Reid National Health and Medical Research Council

$602,878.00 $150,720.00 2012-2015 Project grant

National Health and Medical Research Council Practitioner Fellowship

David Reid National Health and Medical Research Council

$300,000.00 $60,000.00 2010-2015 Fellowship

The AMAZES Study: Asthma and Macrolides: the AZithromycin Efficacy and Safety study

Gibson Ian Yang National Health and Medical Research Council

$2,991,000.00 $598,200.00 2009-2013 Project

National Health and Medical Research Council Practitioner Fellowship

Kwun Fong Kwun Fong National Health and Medical Research Council

$436,590.00 $87,318.00 2012-2016 Fellowship

Grants | Living & Breathing | Research

88



TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

National Health and Medical Research Council Career Development Fellowship

Ian Yang Ian Yang National Health and Medical Research Council

$302,796.00 $75,699.00 2012-2015 Fellowship

Biological drivers of lung cancer

M Daniels National Health and Medical Research Council

$85,053.00 $85,053.00 2013 National Health and Medical Research Council PhD scholarship

IMproving Physical ACtivity with Treadmill training following stroke: the stroke-IMPACT RCT trial.

Sandra Brauer Suzanne Kuys National Health and Medical Research Council

$711,000.00 $237,000.00 2013-2015 Project

A stratified randomized control trial of an intensive, comprehensive aphasia program to compare patient outcomes post stroke with usual care.

Linda Worrall Petrea Cornwell, Ann Finnimore


$928,000.00 $0.00 2013-2018 Partnership

Prospective methylation biomarker validation study in lung cancer

Kwun Fong Duhig National Health and Medical Research Council

$510,048.00 $179,016.00 2011-2013 Project

Breathe Well: A Centre for Research Excellence in chronic respiratory diseases and lung ageing

David Reid National Health and Medical Research Council Centre for Research Excellence

$2,439,690.00 $487,938.00 2011-2016 Project grant

MAPK/ERK pathway in osteoarthritis

Yin Xiao R Crawford National Health and Medical Research Council Project Grants

$384,784.00 $134,558.00 2012-2014

IMproving Physical ACtivity with Treadmill training following stroke: the stroke-IMPACT translation trial.

Suzanne Kuys Office of Health & Medical Research

$248,000.00 $82,600.00 2012-2015 Project

Health Research Fellowship

Scott Bell Office of Health and Medical Research

$750,000.00 $150,000.00 2011-2015 Fellowship


David Reid Office of Health and Medical Research

$750,000.00 $150,000.00 2011-2016 Fellowship

How to build a human lung

Daniel Chambers D Chambers, J McQualter

Perpetual $38,250.00 $19,125.00 2013-2015 Project

A phase II trial of a novel intervention for social language use impairments following traumatic brain injury.

Emma Finch Petrea Cornwell Princess Alexandra Hospital Research Foundation

$20,000.00 $10,000.00 2013-2014 Project

Developing a quality framework for the care of older patients in the Emergency Department (GERI)

Ellen Burkett Fran Kinnear Queensland Emergency Medicine Research Foundation

$11,000.00 2011-2013 project grant


89


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

A randomised controlled trial of interventional versus conservative management treatment of primary spontaneous pneumothorax (PSPx)

Fran Kinnear Queensland Emergency Medicine Research Foundation

$50,086.00 2012-2014 project grant

Queensland Emergency Medicine Research Foundation Capacity Building Grant

Fran Kinnear Queensland Emergency Medicine Research Foundation

$150,000.00 2013-2015 capacity building grant

Deconstructing the immunopathogenesis of non-tuberculous infection

John Miles Scott Bell QIMR-Clinician Research Collaboration Award

$50,000.00 $25,000.00 2013-2014 Project grant

Program Inflammatory airways disease in children with a focus in cystic fibrosis

Peter Sly Scott Bell Qld Children’s Medical Research Institute

$2.25 million $450,000.00 2010-2014 Project grant

CT compare phase II) CT coronary angiography assessment of emergency patients presenting with undifferentiated chest pain and intermediate risk of coronary artery disease (2009-2013)

Darren Walters Queensland Emergency Medicine Research Foundation

$50,000.00 Project

Evaluation of health care utilisation benefits following pulmonary rehabilitation across twenty programs throughout Queensland

James Walsh D Chambers, S Yerkovich

Queensland Health - Health Practitioner Research Grant

$26,241.95 $26,241.95 2013 Project


Daniel Chambers Queensland Health (Office of Health and Medical Research, OHMR)

$750,000.00 $150,000.00 2011-2015 Fellowship

Functional outcomes for patients at 6 and 18 weeks follow up after fractured neck of femur: a randomised control trial

Rebecca Ferrier Nancy Low Choy

Queensland Health Health Practitioner Grants

$19,565.00 $9,782.50 2013-2014 Project

Diabetes foot ulcer study: Investigating gait and plantar pressure characterisits of type 2 diabetes and its relationship to foot ulceration.

Malindu Fernando Peter Lazzarini Queensland Health Health Practitioner Grants

$19,809.00 $19,809.00 2013-14 Project

Diabetes Amputation Mobile Phone (DAMP) Project: Does regular mobile phone image monitoring of diabetic foot ulcers improve patient outcomes?

Damien Clark Peter Lazzarini, Ewan Kinnear

Queensland Health Health Practitioner Grants

$18,386.00 $0.00 2013-14 Project

Evaluation of health care utilisation benefits following pulmonary rehabilitation across twenty programs throughout QLD

James Walsh Queensland Health Health Practitioner Grants

$26,242.00 $26,242.00 2013-2014 Project


90



TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Delivering heart failure rehabilitation programs to patients at home via tele-rehabilitation: a randomised controlled trial

Jared Bruning Queensland Health Health Practitioner Grants

$19,950.00 $9,975.00 2013-2014 Project

Longer term outcomes from immediate and delayed (wait-list) service models to inform best practice for the Vestibular Rehabilitation Service at TPCH

Vicky Stewart Nancy Low Choy

Queensland Physiotherapy Rehabilitation Network

$2,000.00 $2,000.00 2013 Project

A novel ex-vivo model of human lung disease to treat Pulmonary Arterial Hypertension

Daniel Chambers S Yerkovich, B Basker

Rebecca L. Cooper Medical Research Foundation Ltd

$11,476.00 $11,476.00 2013 Equipment

RESTORE II (REVA) Darren Walters, Chris Raffel

REVA MEDICAL $10,702.00 Industry sponsored

Assessment of airway rejection in lung transplantation – no longer B grade?

Daniel Chambers ST Yerkovich Roche Organ Transplant Research Fund

CHF 288,008 CHF 100,000 2011-2013 Project

ODYSSEY Christopher Raffel, Darren Walters

Sanofi-Aventis /Covance


MODIFY Darren Walters, Chris Raffel

SERVIER $35,762.00 Industry sponsored

Prevalence and nature of dysphagia in Chronic Obstructive Pulmonary Disease

Michelle Slee Petrea Cornwell, Philip Masel, Ian Yang, Lisa McCarthy

Speech Pathology Austalia

$2,000.00 $2,000.00 2013 Project

ILUMIEN Chris Raffel St Jude Medical $9,833.00 Industry sponsored

ENLIGHTN Darren Walters St Jude Medical $30,186.00 Industry sponsored

Stryker - A Prospective, Randomised, Single-blind, Multi-centre Clinical Study to Evaluate the Comparative Effectiveness of the Scorpio and Mobile Bearing Knee (R. Crawford)

R Crawford R Crawford Stryker South Pacific - Australia

$1,071,985.00 $108,000.00 2002-2013

Optical Coherence Tomography (2012-2013)

Darren Walters The Prince Charles Hospital Foundation

$40,000.00 Project grant

MA24PAU perivascular flow sensor

Shaun Gregory The Prince Charles Hospital Foundation

$3,920.00 2013 Small Equipment Grant

Understanding biofilm in Pseudomonas aeruginosa infection derived from different niches

Scott Bell David Reid The Prince Charles Hospital Foundation

$83,500.00 $41,750.00 2012-2013 Project grant


91


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Detection of treatment-responsive lung cancer mutations

Brett Hughes Rayleen Bowman, Kwun Fong, Felicia Goh, Houston

The Prince Charles Hospital Foundation

$94,515.00 2013 (extended)

Experienced Researcher, Project

Personalised lung cancer treatment with precise molecular genotyping

Kwun Fong Rayleen Bowman, Ian Yang, Leong


$99,515.00 2013 (extended)

Experienced Researcher, Project

Precision Molecular Diagnosis for lung cancer

Kwun Fong Rayleen Bowman, Clarke


$99,793.00 $99,793.00 2013 Experienced Researcher, Project

Whole genome sequencing for neuroendocrine lung cancer

Kwun Fong Rayleen Bowman, Ian Yang, Clarke


$99,586.00 $99,586.00 2013 Experienced Researcher, Project

Is FGFR1 amplification an early lung cancer biomarker?

Marissa Daniels The Prince Charles Hospital Foundation

$9,174.00 $9,174.00 2013 New Researcher

Epigenetic changes in the ageing lung

Emily Impey The Prince Charles Hospital Foundation

$9,792.00 $9,792.00 2013 New Researcher

The effects of primary versus aged diesel emissions on bronchial epithelial cells at an air-liquid interface

Annalicia Vaughan The Prince Charles Hospital Foundation

$9,831.00 $9,831.00 21013 New Researcher

Optimising 3D spheroid tumour model for personalized cancer treatment.

Tianmun (Kelly) Chee


$9,976.00 $9,976.00 2013 New Researcher

Finding cancer mutations in bronchial washing samples

Louise Franz The Prince Charles Hospital Foundation

$9,976.00 $9,976.00 2013 New Researcher

Equipment grant for Ion Proton and Ion Personal Genome Machine items

Kwun Fong The Prince Charles Hospital Foundation

$3,777.00 $3,777.00 2013 The Prince Charles Hospital Foundation equipment grant (small)

Minus 86°C Freezer John Fraser The Prince Charles Hospital Foundation

$5,695.00 2013 Large Equipment Grant

Belts for Respitrace QDC 220V machine

Anna-Lisa Sutt The Prince Charles Hospital Foundation

$592.90 2013 Small Equipment Grant

Sepsis risk with aged vs fresh red blood cell transfusions: A retrospective study

Beatrice Sim The Prince Charles Hospital Foundation

$9,780.50 2013 New Researcher Grant

MPW-55 micro-centrifuge

Saul Chemonges The Prince Charles Hospital Foundation



92



TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

The double whammy: impact of activated endothelium and stored blood transfusion on microparticle formation and thrombosis

Monica Ng The Prince Charles Hospital Foundation


Study of Disposition of Macro and Micronutrients in Ex-Vivo Extra Corporeal Membrane Oxygenation (ECMO) Circuits To Optimise Nutritional Delivery during ECMO

Kristine Estensen The Prince Charles Hospital Foundation


Development of a novel assay to characterise the inflammatory responses to transfusion of stored blood in an ovine model of smoke-induced acute lung injury and extracorporeal membrane oxygenation.

Eunike McGowan The Prince Charles Hospital Foundation


What are the prevelance rates of foot complications in inpatient populations?

Peter Lazzarini Suzanne Kuys, Ewan Kinnear

Wound Management Innovation CRC

$30,000.00 $30,000.00 2013-14 Scholarship

Improving communication in the ventilated patient: assessing changes in lung volume when using a speaking valve.

Anna-Lisa Sutt The Prince Charles Hospital Foundation


Alteration of high mobility group box 1 expression accelerates pathogenesis in calcific aortic valve stenosis

Yoke Lin Fung Margaret Passmore, Maria Nataatmadja, Bronwyn Pearse, Peter Tesar, John Fraser


$80,445.34 2013-2014 Experienced researcher Grant

Silent and Apparent Neurological Injury In Transcatheter Aortic Valve Implantation (SANITY) Study

John Fraser Jonathon Fanning, Darren Walters, Judith Bellapart, Andrew Clarke


$99,272.00 2013 Experienced researcher Grant

The lmplications of Brain Death in Donor Lung lnjury: lnvestigation and Blockade of the Endothelin Axis

Ryan Watts The Prince Charles Hospital Foundation


Validating the cryopreservation of ovine red blood cells for use in ovine models of transfusion

Elissa Milford The Prince Charles Hospital Foundation


Fibreoptic spectrometer Ashwaths Rajamani The Prince Charles Hospital Foundation


Force Transducer Frank Nestler The Prince Charles Hospital Foundation



93


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Systemic Venous Compliance Chamber with Flow Sensor

Michael Stevens The Prince Charles Hospital Foundation


Physiological Controller Development for the BiVACOR Total Artificial Heart

Frank Nestler The Prince Charles Hospital Foundation


Improving the implantability of a total artificial heart through miniaturisation of the BiVACOR™ controller.

David Morales The Prince Charles Hospital Foundation


Development and in-vivo evaluation of a novel inflow cannula for ventricular assist devices.

Shaun Gregory Bruce Thomson, John Fraser



Determination of mechanisms of ventricular interaction responsible for right ventricular failure found with left ventricular assist device implantation.

John Fraser Mohanraj Karunanithi, David Platts, Haris Haqqani, Bruce Thomson, Shaun Gregory



Development of a robust control strategy for Ventricular Assist Devices

Ashwaths Rajamani The Prince Charles Hospital Foundation

$9,209.55 2013 New Investigator Grant

Developing an Injectable Drug Containing Hyaluronic Acid (HA) and ERK signaling pathway Modulators for Osteoarthritis Treatment.

Yin Xiao R Crawford The Prince Charles Hospital Foundation

$73,250.00 $73,250.00 2012-2013 Project grant

Jeff Overington The University of Queensland

$24,652.00 $12,326.00 2013-2014 The University of Queensland MPhil scholarship

A prospective evaluation of the utility of ultrasound guided radial artery cannulation versus the traditional blind palpation technique in adult cardiac surgical patients.

Justin Wong Ivan Rapchuk The Prince Charles Hospital Foundation

$9,489.02 $9,489.02 2013-2014 New Investigator Grant

Obesity and Activity in Heart Transplant Recipients

Scott McKenzie Rebecca Francis The Prince Charles Hospital Foundation

$9,498.64 - - New Investigator Grant

Marfan syndrome: using next-generation sequencing to identify Mendelian mutations and modifying genes.

M West, M Brown, E Duncan, K Summers


$91,000.00 2013 Project grant

Notch1, ApoE and osteopontin dysfunction in bicuspid aortic valve associated with aortic aneurysm.

M West, A Dettrick, M Nataatmadja, P Walker, J West, M Passmore


$98,432.00 2013-2014 Project grant


94



TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Radiometer TCM4 transcutaneous monitor and Sensor for tcpCO2 and tcpO2 (Adults and Paediatric).

Fran Kinnear The Prince Charles Hospital Foundation


Functional outcomes at discharge in people with Hip Fracture, based on fracture stability and fixation

Rebecca Ferrier The Prince Charles Hospital Foundation

$9,982.92 2013 New Investigator Grant

Cardiac Indigenous patients’ and their relatives’ experience of acute hospital care

V Mbuzi P Fulbrook The Prince Charles Hospital Foundation

$9,978.15 $9,978.15 2014 New Investigator Grant

Digital camera P Fulbrook The Prince Charles Hospital Foundation

$4,533.38 $4,533.38 2014 Small Research Equipment Grant

Intra-strain diversity of Pseudomonas aeruginosa in the lungs of patients with CF and their role in exacerbation

Scott Bell The Prince Charles Hospital Foundation

$94,797.00 $47,398.00 2013-2014 Project grant

Physical Activity and Inflammatory markers in people with CF post hospitalisation

Kate Myslinski The Prince Charles Hospital Foundation

$10, 000 $10, 000 2013 New Investigator Grant

A randomised controlled trial of recreational therapy for Behavioural and Psychiatric Symptoms of Dementia

Leah Thompson Eamonn Eeles, Mujtaba Ahmed, Emily Gibbs


$9,676.45 New Investigator Grant

Vestibular, Balance and Mobility Research Clinics at TPCH

Nancy Low Choy Aaron Lamont, Rachel Williams, Greg Morrison


$54,680.00 $54,680.00 2013 Equipment

Validation of a Vestibular Screening Tool in the acute hospital setting, in detecting vestibular dysfunction to facilitate referral of patients to Physiotherapy Vestibular Clinic

Vicky Stewart Nancy Low Choy



Maximising balance, mobility and community participation of people after surgery following fractured neck of femur.

Rebecca Ferrier Nancy Low Choy



Does obesity post heart transplant relate to patient activity levels?

Rebecca Francis The Prince Charles Hospital Foundation


Inflammatory markers and physical activity capacity In adult cystic fibrosis population following an acute exacerbation requiring hospitalisation

Kate Myslinski The Prince Charles Hospital Foundation



95


TPCH Investigators

Granting Agency

Total Funding

2013 Funding

Year of Funding

Grant Type

Towards an improved understanding of the effect of a speaking valve on lung volumes and communication in the critically ill tracheostomised patient

Anna-Liisa Sutt John Fraser, Petrea Cornwell, Kimble Dunster



Towards an improved understanding of the effect of a speaking valve on lung volumes and communication in the critically ill tracheostomised patient

Anna-Liisa Sutt John Fraser, Petrea Cornwell, Kimble Dunster


$592.90 $592.90 2013 Equipment

The Lung Transplant Mycobiome

Daniel Chambers The Prince Charles Hospital Foundation

$95,762.00 $95,762.00 2013 Project

Airway stem cell exhaustion – predicting the lifespan of the lung allograft

Stephanie Yerkovich

Daniel Chambers The Prince Charles Hospital Foundation

$82,278.00 $82,278.00 2013 Project

Protein Repletion post lung Transplantation: Early Intervention Nutrition

Donna Hickling The Prince Charles Hospital Foundation Novice


A novel assay to distinguish and identify mesenchymal stem cells within the lung

Kenneth Sinclair The Prince Charles Hospital Foundation


A randomised controlled trial of interventional versus conservative management treatment of primary spontaneous pneumothorax (PSPx)

Simon Brown Fran Kinnear University of Western Australia

$50,000.00 2012-2014 project grant

Intensive care nurses’ experiences of, attitudes towards, end of life care: a New Zealand perspective

M Coombs P Fulbrook University of Victoria

$4,989.00 $4,989.00 2013 Faculty Grant

Cardiac Magnetic Resonance

C Hamilton-Craig C Hamilton-Craig University of Queensland

$60,000.00 $40,000.00 2014-2015 ATHRF Grant

Optimising organ function during ex-vivo lung perfusion – role of the endothelial glycocalyx

Daniel Chambers J Hill University of Queensland Academic Title Holder Research Fund

$37,078.00 $37,078.00 2013 Project

Contexts of learning: impact of an inter-service aged care placement on student interest and confidence in working with people 65 years and older

Ronelle Hewetson Petrea Cornwell Health Workforce Australia

$17,159.00 $17,159.00 2013 Project

Osteoarthritis Research Fund

R Crawford R Crawford Osteoarthritis Research Fund

$9,880.00 $10,130.00 2011-2021


96


Living & Breathing | Research | The Prince Charles Hospital Foundation

Australia’s population is ageing

and chronic disease is on the rise,

contributing to 90% of deaths. The


supports research to fight Australia’s

most chronic diseases and debilitating

conditions.

Since we were established in 1986,

the Foundation has provided more

than $16 million in grant funding to

researchers at The Prince Charles

Hospital. These grants have covered

a vast range of health research from

across the hospital, including surgery,

nursing, nutrition, physiotherapy,

mental health, transplantation, pure

science, and speech pathology.

This could not have been achieved

without the generous support of

community donors, payroll donors,

corporate partners, event participants,

and volunteers.

We fund researchers at all stages in

their careers. In 2010, the Foundation

introduced research equipment and

new investigator grants to foster

the next generation of researchers

and provide broader support to the

hospital community. Already 97 new

investigators have been given a start

in research through this program.

As a result of several years of

consistent significant growth, in

2013-14 the Foundation introduced

two new types of grants to support

further research at The Prince Charles

Hospital. We offered Program Grants

to support specific programs of

research across medical areas, such as

multi-disciplinary patient or disease

focussed collaborations. These are

multiple year projects with bulk

funding of $200,000 per year.

Building capacity for health and

medical researchers is an important

aim for the Foundation. To support

this, we created PhD scholarships of

$25,000 per year for three years. This

will allow PhD students to reduce their

paid working hours if necessary to

dedicate more time to their research

projects.

These new grants brought our

funding pool for the year to over

$2.1m. The Foundation’s goal is to

distribute $5m annually in health and

medical research funding by 2018.

We raise money through donations,

bequests, fundraising events,

appeals, and commercial activities

such as managing the Breeze Café

and catering service to offset our

administration costs.

We are committed to helping our

health and medical researchers find

new ways to diagnose and treat early,

to prevent and cure the chronic,

congenital and acquired diseases

which cause suffering in Australia and

around the world.

For information on research we

support and to make a donation, visit

www.tpchfoundation.org.au.


97Research Partners | Living & Breathing | Research

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Living & Breathing | Research | Research Partners

Research Partners

Regenerative Medicine

99Research Partners | Living & Breathing | Research

Regenerative Medicine

100


Living & Breathing | Research | Higher Research Degree Students

Name Higher Degree

Project University Affiliation

Primary Supervisor

TPCH Supervisor(s)

Niru Mahendran

PhD Ambulation recovery after stroke The University of Queensland

Sandra Brauer Suzanne Kuys

Lee Pryoir PhD Evaluating speech pathology practice in the intensive care unit


Elizabeth Ward Petrea Cornwell

Sarah Mattin PhD Readiness for discharge from hospital to home in community: physiotherapist, family/caregiver and patient perspectives.


Nancy Low Choy Suzanne Kuys

Hannah Tehan

PhD Brain Training in Prospective Memory for Those Suffering the Effects of Stroke or Other Forms of Acquired Brain Injury


Mia Mariani

Peter Lazzarini

PhD Prevalence and risk factors of foot disease in inpatient populations


Lloyd Reed Suzanne Kuys

Malindu Fernando

PhD Plantar pressure and gait characteristics of diabetes foot ulcers

James Cook University

Jonathon Golledge Peter Lazzarini

Sharon Kwiatkowski

PhD Investigation of home based exercise for severe COPD

Griffith University Norman Morris Suzanne Kuys

Julie Adsett PhD Safety, efficacy and acceptability of aquatic exercise for patients with chronic heart failure

Griffith University Norman Morris Suzanne Kuys

Judith Sheridan

PhD Exploring adherence to medical recommendations in the lung transplant populations


D Kavanagh Daniel Chambers

Anna-Liisa Sutt

PhD Towards an improved understanding of the effect of a speaking valve on lung volumes and communication in the critically ill tracheostomised patient


John Fraser Petrea Cornwell

James Walsh PhD Predictive Factors of Success in Pulmonary Rehabilitation


J Paratz N Morris

Nicole Bellet PhD Outcomes in Cardiac Rehabilitation: Use of the 6MWT, TUGT and the effects of Frequency of Program Delivery

Griffith University N Morris N Morris

Ellie Newman

PhD An Exploration of Adjustment in Adult Congenital Heart Disease


Esben Strodl Judith Sheridan, Dorothy Radford

Jim Crowhurst

PhD Darren Walters

Nazil Bashi PhD Darren Walters

Katie Gillette PhD Beta-adrenoceptor determinants of contractility and arrhythmias in the human heart: the role of phosphodiesterase enzymes and ryanodine channels.


Peter Molenaar

Higher Research Degree Students

101Higher Research Degree Students | Living & Breathing | Research

Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

Charles McDonald

PhD Oxidative stress and selenium modulation in extra corporeal membrane oxygenation.


John Fraser John Fraser

Rob Phillips PhD USCOM: Development of a non-invasive haemodynamic device.


John Fraser Malcolm West

David Platts PhD Novel clinical indications and the interaction with mechanical cardiac circulatory support devices


John Fraser Malcolm West

Kiran Shekar PhD Characterisation of pharmacokinetics of commonly used sedatives, analgesics, broad spectrum antibiotics and their clinically relevant metabolites during ECMO using simulated circuits, clinical studies and an ovine model.



Jonothan Fanning

PhD The cerebral autoregulartory mechanism during intra-aortic balloon pump counterpulsation (IABP) weaning.



Jo Phillip Pauls

PhD Development of a Passive Physiological Control System for Ventricular Assist Devices

Griffith University Geoff Tansley John Fraser

Yunhui Chen PhD Advanced manufacturing method for hard and brittle materials


Han Huang John Fraser

Frank Nestler

PhD The cerebral autoregulartory mechanism during intra-aortic balloon pump counterpulsation (IABP) weaning.



Michael Stevens

PhD Physiological control of rotary biventricular assist devices



Anthony Yuen

PhD A Pilot Study on Haemocompatibility and the Effect of Pulsatility on Platelets in Artificial Hearts.



Qurain Alshammari

PhD MRI Relaxometry in hyperetension UQ Centre for Advanced Imaging

G Galloway C Hamilton-Craig

Greg Brown PhD T2* in cardiac iron overload UQ Centre for Advanced Imaging

G Galloway C Hamilton-Craig

Sushil Luis PhD MultiModality imaging in cardiac disease UQ School of Medicine

Chris Raffel C Hamilton-Craig

Sandra Miles PhD Able-Bodied Children and Education Australian Catholic University

Paul Fulbrook

Petra Lawrence

PhD A randomised controlled trial of a psychosocial intervention for emergency department attendees with moderate psychological distress


Paul Fulbrook

Vainess Mbuzi

PhD Indigenous peoples' experiences of acute cardiac care


Paul Fulbrook Melanie Jessup

Alison Peeler PhD Provision of a new paediatric service: An investigation of staff and ED attendees perceptions and experience of the transition from an adult emergency department


Paul Fulbrook Frances Kinnear

Lynn Hoey PhD Sleep quality in acute hospitalised patients Australian Catholic University

Paul Fulbrook James Douglas

Isaac Oluwaseun Afara

PhD Near infrared spectroscopy for non-destructive evaluation of articular cartilage


Adekunle Oloyede Ross Crawford

102


Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

June Evelyn Jeon

PhD Development of zonal cartilage constructs : effects of chondrocyte subpopulation, compressive stimulation, and culture models


Travis Klein Ross Crawford

John Andrew Roe

PhD How important is length? : mechanical testing and measurement of a cemented, polished, tapered femoral implant


Ross Crawford Ross Crawford

Nishant Chakravorty

PhD Role of Micro-RNAs in imporved Osteogenicity of Modified Titanium Implant Surfaces.


Yin Xiao Ross Crawford

Zetao Chen PhD Regulating the immune response to bone substitute materials to improve osteogenesis



Nghiem Van Trong Doan

PhD An evaluation of clinical procedures used in dental Implant treatment in posterior maxilla using flapless technique



Saba Farnaghi

PhD Obesity and osteoarthritis: A new insight in understanding the role of leptin-induced osteocytes in osteoarthritis pathogenesis.



Thor - Einar Friis

PhD The ancient gene C12ORF29: an exploration of its role in the chordate body plan


Dietmar Hutmacher Ross Crawford

Pingping Han

PhD The Regulation of Wnt Canonical Signalling Pathway during Cementum Regeneration



Yuanbiao Liu PhD Functional Adaptations and Rehabilitation following Total Knee Replacement


Anthony Parker Ross Crawford

Timothy John McMeniman

PhD Fixation Methods in Impaction Bone Grafting of the Acetabulum in Revision Total Hip Arthroplasty: An in vitro study



Hoi Ting Shiu PhD Controlling whole blood activation and Resultant clot properties on various material surfaces: a possible therapeutic approach for enhancing bone healing


Benjamin Goss Ross Crawford

Anjali Tumkur Jaiprakash

PhD Osteocytes in the Development and Progression of Osteoarthritis.



Kehinde Quasim Yusuf

PhD An exploratory study of the potential of resurfacing articular cartilage with synthetic phospholipids


Adekunle Oloyede Ross Crawford

Xufang Zhang

PhD Pro-angiogenic and anti-angiogenic factors in the degeneration of osteoarthritic cartilage



Yinghong Zhou

PhD Interactions between Undifferentiated and Osteogenic Differentiated Mesenchymal Stromal Cells during Osteogenesis



Daniel Smith PhD The effect of defective iron handling on immune function and Pseudmonas aeruginosa in the Cystic Fibrosis lung

QIMR Berghofer David Reid Scott Bell

Anna Tai PhD Molecular mechanism of carbapenem resistance in Pseudomonas aeruginosa from patients with cysitc fibrosis

Queensland Children's Medical Research Institute

Scott Bell


103

Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

Kay Ramsay PhD Phenotypic and genotypic characterisation of Pseudomonas aeruginosa to determine the differences between adaptation, adherence and transmission amongst strains isolated from the environment and patients with cystic fibrosis

Queensland Children's Medical Research Institute

Timothy Kidd David Reid, Scott Bell

Janet Shaw PhD Biomarkers in COPD The University of Queensland School of Medicine

Ian Yang Kwun Fong, Rayleen Bowman, Paul Zimmerman

Kelly Chee PhD Next generation sequencing analysis of thoracic malignancies - optimisation of bioinformatics for somatic variant identification and validation strategies towards personalised therapy

The University of Queensland School of Medicine

Rayleen Bowman Kwun Fong, Ian Yang

Santiyagu Savarimuthu

PhD Molecular genetics of innate immunity in lung diseases


Ian Yang Kwun Fong, Rayleen Bowman

Casey Wright

PhD Asbestos-related lung disease The University of Queensland School of Medicine

Kwun Fong Rayleen Bowman, Ian Yang

Annette Dent

PhD Exhaled breath volatile organic compounds in lung disease



Henry Marshall

PhD Screening for lung cancer by low-dose computerised tomography in Australia



Marissa Daniels

PhD Genomic and epigenomic changes in lung malignancy



Krishna Sriram

PhD Lung cancer/mesothelioma; Biomarkers in lung cancer and pleural malignancy



Kenneth Sinclair

PhD Resident stem/progenitor cells & mesenchymal stromal cells in lung health and disease


Daniel Chambers Stephanie Yerkovich

Susan Pizzutto

PhD Characterisation of non cystic fibrosis chronic lung disease in Northern Territory children

Charles Darwin University

Anne Chang Stephanie Yerkovich

Danielle Wurzel

PhD Protracted bacterial bronchitis (PBB) in children – natural history, innate immunity, infection and obstructive sleep disorders


Anne Chang Stephanie Yerkovich

Judith Sheridan

PhD Adherance after lung transplantation Queensland University of Technology

David Kavanagh Daniel Chambers

Steven Leong

PhD (withdrawn)

Bronchoscopic approaches to lung cancer The University of Queensland School of Medicine


Michael Seco MBBS/ PhD Minimising the invasiveness of cardiac surgery The University of Queensland


Adrian Singh Masters by Research

The association between socioeconomic, indigenous and geographic status and diabetic foot complications


Gavin Turrell Peter Lazzarini

Damien Clark

Masters by Research

What effect does transmitting images by mobile phone have on diagnosing diabetic foot complicaitons


Lloyd Reed Peter Lazzarini, Petrea Cornwell

Higher Research Degree Students | Living & Breathing | Research

104


Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

Vicky Stewart

MPhil Validation of a Vestibular screening tool to facilitate referral to physiotherapy vestibular services in the actue hospital setting


Nancy Low Choy Nancy Low Choy

Rebecca Ferrier

MPhil Australian Catholic University

Nancy Low Choy Nancy Low Choy

Janelle Gesch

MPhil Development, validation, reliability and predictive capacity of motor recovery of the Acquired Brain Injury Physiotherapy Assessment (ABIPA): A tool for physiotherapists during early management of people following traumatic brain injury

Griffith University Suzanne Kuys Suzanne Kuys

Praline Choolun

MPhil Tracking changes in scapular position in acute post-stroke hemiplegic patients

Griffith University Leanne Bisset Suzanne Kuys

Urszula Dolecka

MPhil Spaced retrieval, erroroless learning and vanishing cues in retraining of sit to stand in people with dementia

Griffith University Suzanne Kuys Suzanne Kuys

Heather Batten

MPhil Functional outcomes of lower limb amputees The University of Queensland

Allison Mandruisak Suzanne Kuys

Erin Stanley MPhil Investigating the impact a Saturday rehabilitation physiotherapy service has on patient outcomes and length of stay


Sandra Brauer Suzanne Kuys

Claire Stewart

MPhil Increasing the amount of practice completed by stroke inpatients.

University of Sydney Annie McCluskey Suzanne Kuys

Alexander Incani

MPhil Optical coherence tomography assessment of intermediate coronary stenosis


Darren Walters, Chris Raffel


Karl Poon MPhil Percutaneous treatment of valvular heart disease - improving patient selection and optimising outcomes




Dale Mudoch MPhil Darren Walters, Malcolm West

Darren Walters, Malcolm West

Joseph Hanna

MPhil Heart function in Marfan syndrome External M Phil student

Malcolm West Daryl Burstow

John Hunter MPhil Cardiovascular risk profiling in Samoan subjects (SPACIFIC Study)

External M Phil student

Malcolm West Malcolm West

Daniel Mullany

MPhil The effect of new technology and organisational characteristics on risk modelling and outcome predictions in the cardiac surgical ICU.


Malcolm West John Fraser

D Roper MPhil Malcolm West

Natasha van Zyl

MPhil Validation of Acute Traumatic Coaulopathy in an ovine model of trauma and haemorrhage


John Fraser

Ryan Watts MPhil The implications of brain death in donor lung injury: investigation and blockade of the endothelin axis.



Elissa Milford MPhil Effects of commonly used and emerging resuscitation fluids on end organ function in severe trauma.



David Morales

MPhil Improving the implantability of a total artificial heart through miniaturization of the BiVACOR™ controller.


John Fraser


105

Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

Kristin Moser MPhil The University of Queensland

John Fraser

Eric Wu MPhil Development of a physiological control system that relates total LVAD and left ventricular work to preload


Andrew Bradley John Fraser

Stephanie Gettens

MPhil Psychosocial implications of sustaining a fall while in hospital


Paul Fulbrook Melanie Jessup

Kate Myslinski

MPhil Physical Activity and Inflammatory markers in people with CF post hospitalisation

Griffith University David Reid David Reid

Barbara Page

MPhil Rural journey for lung cancer patients The University of Queensland School of Medicine


Jeffrey Overington

MPhil Use of electronic COPD checklists The University of Queensland School of Medicine


Timothy Sladden

MPhil The role of the glycocalyx in lung transplantation


Daniel Chambers Stephanie Yerkovich

Mauren Peasey

MPhil Baseline Characteristics do not Predict Physical Activity in COPD patients pre-Pulmonary Rehabilitation

Griffith University Norman Morris James Walsh

Cathy Saxon MN (Research) Patients with chronic respiratory disease: experiences of bronchoscopy


Paul Fulbrook Kwun Fong

Rachel Teis MN (Research) The use of prompts based on crisis resource management principles to improve resuscitation team performance


Sue Kildea Paul Fulbrook

Jodie Lay MN (Research) Falls injury prevention Australian Catholic University

Paul Fulbrook Paul Fulbrook

Christine Chau

MClin Pharm Tolerability of azole antifungals after lung transplantation


Stephanie Henning Daniel Chambers, Tracy Tse

Gregory Bennett Couzens

Masters by Research

The Role of Wrist Motors in Carpal Stability Queensland University of Technology


Ali Kalhor Masters by Research

Effects of hyperbaric oxygen and inducible nitric oxide inhibitor treatment on femoral head osteonecrosis in a rat model



Praveen Vijaysegaran

Masters by Research

An analysis of variables affecting the quality of orthopaedic laminar airflow systems



Hao Yu Masters by Research

Comparison of the subchondral plate in osteoarthritis and osteoporosis in an animal model



Noel Wong Honours The Development of a Silicone Right Heart Model for use as a Training Rig for Endomyocardial Biopsies


Shaun Gregory John Fraser

Adrian Lowry

Honours John Fraser

Higher Research Degree Students | Living & Breathing | Research

106


Name Higher Degree


Primary Supervisor

TPCH Supervisor(s)

Emma Schummy

Honours Design and validation of a compliant, banded outflow cannula for decreasing the after-load sensitivity of rotary right ventricular assist devices


Mark Pearcy John Fraser

Krystine Chung

Honours Comparison of physiological controllers for LVADs

Geoff Tansley John Fraser

Masoud Hashemi

Honours Design and Construction of Mock Circulatory System to Evaluate VAD Inflow Cannula Using Naturally Shaped Silicone Ventricle

Geoff Tansley John Fraser

Tom Burgess Honours John Fraser

Ashleigh Bond

Honours John Fraser

Adrian Tai Honours John Fraser

Thomas Crn Honours John Fraser

Elyse Fitzpatrick

Honours The association between emergency department admission time and occurence of pressure injury


Sandra Miles Sandra Miles

Danielle Edwards

BSc Hons Taste GPCR mediated contractile effects in human cardiac tissue. A novel investigation into their functional role.

Peter Molenaar

Dianna Luong

MBBS Hons Exhaled breath condensate measurement The University of Queensland School of Medicine


Wen Lee MBBS Hons Digital tomosynthesis The University of Queensland School of Medicine


Jacques Eastment

MBBS Hons Cochrane review: prophylactic radiotherapy to present tract metastasis in mesothelioma


Rayleen Bowman Kwun Fong, Ian Yang

Joseph Burke

MBBS Hons Cochrane review: glycopyrronium for COPD The University of Queensland School of Medicine


Claire Robinson

MBBS (Hons) TOMM40 & pulmonary hypertension The University of Queensland

Daniel Chambers Daniel Chambers


107

Sam Foley, research assistant

108


PublicationsAbramson M, AJ Crockett, E Dabscheck, PA Frith, N Glasgow, S Jenkins, CF McDonald, DK McKenzie, R Wood-Baker and I Yang (2013), The COPDX Plan: Australian and New Zealand Guidelines for the management of Chronic Obstructive Pulmonary Disease 2012, Thoracic Society of Australian and New Zealand and Australian Lung Foundation

Ashraf O and H Sharif (2013), "Cardiac failure, transplantation and donation: current perspectives." J Cardiovasc Surg (Torino)

Asmussen S, DM Maybauer, JF Fraser, K Jennings, S George, A Keiralla and MO Maybauer (2013), "Extracorporeal membrane oxygenation in burn and smoke inhalation injury." Burns 39(3): 429-435

Asmussen S, DM Maybauer, JF Fraser, K Jennings, S George and MO Maybauer (2013), "A meta-analysis of analgesic and sedative effects of dexmedetomidine in burn patients." Burns 39(4): 625-631

Aubron C, MC Reade, JF Fraser and DJ Cooper (2014), "Efficacy and safety of fibrinogen concentrate in trauma patients--a systematic review." J Crit Care 29(3): 471 e411-477

Aung T, K Poon, R Horvath, C Coulter and DL Walters (2013), "A case series of medically managed infective endocarditis after transcatheter aortic valve replacement." Scand J Infect Dis 45(6): 489-493

Barnett AG, M Lucas, D Platts, E Whiting and JF Fraser (2013), "The benefits of thermal clothing during winter in patients with heart failure: a pilot randomised controlled trial." BMJ Open 3(4)

Bell J, J Bauer, S Capra and CR Pulle (2013), "Barriers to nutritional intake in patients with acute hip fracture: time to treat malnutrition as a disease and food as a medicine?" Can J Physiol Pharmacol 91(6): 489-495

Bell JJ, JD Bauer and S Capra (2013), "The malnutrition screening tool versus objective measures to detect malnutrition in hip fracture." J Hum Nutr Diet 26(6): 519-526

Bell JJ, JD Bauer, S Capra and CR Pulle (2013), "Multidisciplinary, multi-modal nutritional care in acute hip fracture inpatients - Results of a pragmatic intervention." Clin Nutr

Bell SC, D Hartl and H Heijerman (2013), "Change in the Executive Team at JCF." J Cystic Fibrosis 12(6): 545-546

Bellapart J, KR Dunster, S Diab, DG Platts, C Raffel, L Gabrielian, MO Maybauer, A Barnett, RJ Boots and JF Fraser (2013), "Intracardiac echocardiography guided transeptal catheter injection of microspheres for assessment of cerebral microcirculation in experimental models." Cardiology Research and Practice 1(1)

Bellet RN, RL Francis, JS Jacob, KM Healy, HJ Bartlett, L Adams and NR Morris (2013), "Timed Up and Go Tests in cardiac rehabilitation: reliability and comparison with the 6-Minute Walk Test." J Cardiopulm Rehabil Prev 33(2): 99-105

Bergin SM, VL Nube, JB Alford, BP Allard, JM Gurr, EL Holland, MW Horsley, MC Kamp, PA Lazzarini, AK Sinha JT Warnock and PR Wraight (2013), "Australian Diabetes Foot Network: practical guideline on the provision of footwear for people with diabetes." Journal of Foot and Ankle Research 6(1): 6-6

Bhaskar B, M Zeigenfuss, J Choudhary and JF Fraser (2013), "Use of recombinant activated Factor VII for refractory after lung transplant bleeding as an effective strategy to restrict blood transfusion and associated complications." Transfusion 53(4): 798-804

Brew CJ, LJ Wilson, SL Whitehouse, MJ Hubble and RW Crawford (2013), "Cement-in-cement revision for selected Vancouver Type B1 femoral periprosthetic fractures: a biomechanical analysis." J Arthroplasty 28(3): 521-525

Brown M, C Hamilton-Craig, G Javorsky, S McKenzie, D Platts and D Burstow (2013), "Right Atrial Pressure Evaluation Comparing Invasive Right Heart Catheterisation and Simultaneous Transthoracic Echocardiography Using Old and New ASE Guidelines." Heart, Lung and Circulation 22: S196

Brown M, C Hamilton-Craig, G Javorsky, S McKenzie, D Platts and D Burstow (2013), "Transthoracic Echocardiography Guided Assessment of Pulmonary Vascular Resistance – Time for a New Formula." Heart, Lung and Circulation 22: S203-S204

Brown MR, A Dettrick, G Javorsky, SC McKenzie and DG Platts (2013), "Indolent cardiac angioma mimicking hypertrophic obstructive cardiomyopathy and causing right ventricular outflow tract obstruction." European Heart Journal Cardiovascular Imaging 14(7): 718

Burke JP, JG Eastment, RV Bowman, KM Fong and IA Yang (2013), "Glycopyrronium bromide for chronic obstructive pulmonary disease." Cochrane Library Pubished online on 31 OCT 2013: DOI: 10.1002/14651858.CD14010798

Living & Breathing | Research | Publications

109

Camuglia AC, SA Luis, A Sengupta, JH Bett and DL Walters (2013), "Pre-hospital fibrinolysis in the management of patients with ST elevation acute coronary syndrome: review of the evidence, implementation and future directions." Cardiovasc Hematol Disord Drug Targets 13(3): 243-255

Cartmill B, PL Cornwell, E Ward, W Davidson, R Nund, C Bettington, R Masoud Rahbari, M Poulsen and S Porceddu (2013), "Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer." Head and Neck 35(8): 1211-1219

Cartmill B, PL Cornwell, E Ward, W Davidson and S Porceddu (2013), "A prospective study examining the onset and progression of acute toxicity and patient-reported side effects during altered fractionation radiotherapy with concomitant boost for oropharyngeal cancer." World Journal of Surgical Medical and Radiation Oncology 2:6

Cawley PJ, C Hamilton-Craig, DS Owens, EV Krieger, WE Strugnell, L Mitsumori, CL D'Jang, RG Schwaegler, KQ Nguyen, B Nguyen, JH Maki and CM Otto (2013), "Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and transthoracic echocardiography." Circ Cardiovasc Imaging 6(1): 48-57

Chambers DC, B Davies, A Mathews, ST Yerkovich and PM Hopkins (2013), "Bronchiolitis obliterans syndrome, hypogammaglobulinemia, and infectious complications of lung transplantation." J Heart Lung Transplant 32(1): 36-43

Chambers DC and PM Hopkins (2013), "Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach." Am J Respir Crit Care Med 188(2): 252-253

Chan SS, MI Pumar, SC Leong, RL Horvath, HM Marshall, IA Yang and KM Fong (2013), "Electromagnetic navigation bronchoscopy for the diagnosis of Aspergillus infection." Respirology Case Reports (in press).

Chang WW, JY Hyung, HY Sung, OK Chang, CID Lourdes, M Akishita, J Rowland, HH Chang, J Wang, A Masahiro, TT Lian, C Lum, and O Prakahsh (2013), “List of Geriatric syndromes in the Asian-Pacific geriatric societies.” European Geriatric Medicine 4(5):335-338

Chaudhuri A and D Ruzek (2013), "First documented case of imported tick-borne encephalitis in Australia." Intern Med J 43(1): 93-96

Chen TS, A Incani, TC Butler, K Poon, J Fu, M Savage, M Dahl, DE Callow, D Colburn, C Hammett and DL Walters (2014), "The demographic profile of young patients (<45 years-old) with acute coronary syndromes in Queensland." Heart Lung Circ 23(1): 49-55

Cherian PS, AJ Clarke and DJ Burstow (2014), "Unusual case of acute posteromedial papillary muscle rupture after acute anterior myocardial infarction." Heart Lung Circ 23(1): e16-19

Choolun P, SS Kuys, L Bisset and P Mills (2013), "The glenohumeral joint centre position in acute post-stroke hemiplegia patients: changes in the first six weeks." International Journal of Stroke 8(S2): 21

Choolun P, SS Kuys, L Bisset and P Mills (2013), "Glenohumeral joint position, motor recovery and shoulder pain in acute post-stroke hemiplegia patients." International Journal of Stroke 8(S1): 23

Clark D, L Reed, EM Kinnear and PA Lazzarini (2013), "Evaluating the impact of high risk foot training on undergraduate podiatry students." Journal of Foot & Ankle Research 6(Suppl 1): O7

Clark KW, E Whiting, J Rowland, LE Thompson, I Missenden and G Schellein (2013), "Breaking the mould without breaking the system: the development and pilot of a clinical dashboard at The Prince Charles Hospital." Aust Health Rev 37(3): 304-308

Clarke A, P Wiemers, KK Poon, CN Aroney, G Scalia, D Burstow, DL Walters and P Tesar (2013), "Early experience of transaortic TAVI--the future of surgical TAVI?" Heart Lung Circ 22(4): 265-269

Constantinou M and SS Kuys (2013), "Physiotherapy students find guided journals useful to develop reflective thinking and practice during their first clinical placement: a qualitative study." Physiotherapy 99(1): 49-55

Conway A, J Rolley, K Page and P Fulbrook (2014), "Trends in nurse-administered procedural sedation and analgesia across cardiac catheterisation laboratories in Australia and New Zealand: results of an electronic survey." Aust Crit Care 27(1): 4-10

Conway AW, K Page, JX Rolley and P Fulbrook (2013), "Risk factors for impaired respiratory function during nurse-administered procedural sedation and analgesia in the cardiac catheterisation laboratory: a matched case-control study." European Journal of Cardiovascular Nursing 12(4): 393-399

Conway AW, JX Rolley, P Fulbrook and K Page (2013), "Issues and challenges associated with nurse-administered procedural sedation and analgesia in the cardiac catheterisation laboratory: a qualitative study." Journal of Clinical Nursing 23(3-4): 374-384

Conway AW, JX Rolley, P Fulbrook, K Page and DR Thompson (2013), "Improving statistical analysis of matched case-control studies in the nursing literature." Research in Nursing and Health 36(3): 320-324

Conway AW, JX Rolley, K Page and P Fulbrook (2013), "Clinical practice guidelines for nurse administered procedural sedation and analgesia in the cardiac catheterisation laboratory: a modified Delphi study." Journal of Advanced Nursing 70(5): 1040-1053

Publications | Living & Breathing | Research

110


Conway AW, JX Rolley, K Page and P Fulbrook (2013), "Trends in nurse-administered procedural sedation and analgesia across cardiac catheterisation laboratories in Australia and New Zealand: results of on electronic survey." Australian Critical Care 27(1): 4-10

Corley A, N Sharpe, LR Caruana, AJ Spooner and JF Fraser (2014), "Lung volume changes during cleaning of closed endotracheal suction catheters: a randomized crossover study using electrical impedance tomography." Respir Care 59(4): 497-503

Corte TJ, NS Goh, IN Glaspole, CJ Zappala, PM Hopkins and ML Wilsher (2013), "Idiopathic pulmonary fibrosis: is all-cause mortality a practical and realistic end-point for clinical trials?" Thorax 68(5): 491-492

Crawford R (2014), "CORR Insights (R): Loss of cement-bone interlock in retrieved tibial components from total knee arthroplasties." Clin Orthop Relat Res 472(1): 314-315

Crowhurst JA, D Campbell, OC Raffel, M Whitby, P Pathmanathan, S Redmond, A Incani, K Poon, C James, C Aroney, A Clarke and DL Walters (2013), "Using DynaCT for the assessment of ilio-femoral arterial calibre, calcification and tortuosity index in patients selected for trans-catheter aortic valve replacement." Int J Cardiovasc Imaging 29(7): 1537-1545

Daniels MG, RV Bowman, IA Yang, R Govindan and KM Fong (2013), "An emerging place for lung cancer genomics in 2013." J Thorac Dis 5(Suppl 5): S491-S497

Davidson MR, AF Gazdar and BE Clarke (2013), "The pivotal role of pathology in the management of lung cancer." J Thorac Dis 5 Suppl 5: S463-478

Davies MW, KR Dunster, JF Fraser and PB Colditz (2013), "Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation." J Paediatr Child Health 49(12): 1010-1018

De Soyza A, AJ Hall, E Mahenthiralingam, P Drevinek, W Kaca, Z Drulis-Kawa, SR Stoitsova, V Toth, T Coenye, JE Zlosnik, JL Burns, I Sa-Correia, D De Vos, JP Pirnay, T Kidd, D Reid, J Manos, J Klockgether, L Wiehlmann, B Tummler, S McClean and C Winstanley (2013), "Developing an international Pseudomonas aeruginosa reference panel." Microbiologyopen 2(6): 1010-1023

Dent AG, TG Sutedja and PV Zimmerman (2013), "Exhaled breath analysis for lung cancer." J Thorac Dis 5 Suppl 5: S540-550

Devine MJ and DJ Radford (2013), "Treatment of haemoptysis in pulmonary atresia with tranexamic acid." Cardiol Young 23(2): 304-305

Dhanani J, DV Mullany and JF Fraser (2013), "Effect of preoperative renal function on long-term survival after cardiac surgery." J Thorac Cardiovasc Surg 146(1): 90-95

Dobrzynski H, RH Anderson, A Atkinson, Z Borbas, A D'Souza, JF Fraser, S Inada, SJ Logantha, O Monfredi, GM Morris, AF Moorman, T Nikolaidou, H Schneider, V Szuts, IP Temple, J Yanni and MR Boyett (2013), "Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues." Pharmacol Ther 139(2): 260-288

Doran GC, CM Burns, DJ Murdoch, A Incani and DL Walters (2013), "A repeat alcohol septal ablation procedure for hypertrophic obstructive cardiomyopathy where the first septal branch arose from the intermediate (ramus) artery." Heart Lung Circ 22(12): 1026-1029.

Eames S, P Cornwell, M Godfrey and S Cochrane (2013), "Establishing a research project within a Queensland Health Hospital Occupational Therapy Department." Australian Occupational Therapy Journal 60(S1): 102

Eames S, T Hoffmann, L Worrall, S Read and A Wong (2013), "Randomised controlled trial of an education and support package for stroke patients and their carers." BMJ Open 3(5)

Earl BJ, PA Lazzarini, EM Kinnear and PL Cornwell (2013), "High risk feet in subacute rehabilitation facilities: how many are there?" Journal of Foot & Ankle Research 6(Suppl 1): O11

Edelman JJ, YL Fung, GJ Pennings, CJ Reddel, PG Bannon, MS Bayfield, L Kritharides, JF Fraser and MP Vallely (2013), "Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology." Shock 39(2): 149-154

Edelman JJ, CJ Reddel, L Kritharides, PG Bannon, JF Fraser, JL Curnow and MP Vallely (2014), "Natural history of hypercoagulability in patients undergoing coronary revascularization and effect of preoperative myocardial infarction." J Thorac Cardiovasc Surg 148(2): 536-543

Edmunds J, P Fulbrook and S Miles (2013), "Understanding the experiences of mothers who are breastfeeding an infant with tongue tie: a phenomenological study." Journal of Human Lactation 29(2): 150-195

Eeles E and N Low Choy (2013), Frailty and Mobility, Frailty and Ageing: Biological, Clinical and Social Implications. O Theou and K Rockwood, KARGER, Switzerland.

Eeles E, L Thompson, J McCrow and S Pandy (2013), "Management of delirium in medicine: experience of a Close Observation Unit." Australas J Ageing 32(1): 60-63

Eeles EM, S Pandy and JL Ray (2013), "Delirium: a disorder of consciousness?" Med Hypotheses 80(4): 399-404


111

Fanning JP, DG Platts, DL Walters and JF Fraser (2013), "Transcatheter aortic valve implantation (TAVI): Valve design and evolution." International Journal of Cardiology 168(3): 1822-1831

Fanning JP, DL Walters and JF Fraser (2013), "Letter by Fanning et al regarding article, "Histopathology of embolic debris captured during transcatheter aortic valve replacement"." Circulation 128(25): e477

Fernando M, R Crowther, P Lazzarini, K Sangla, M Cunningham, P Buttner and J Golledge (2013), "Biomechanical characteristics of peripheral diabetic neuropathy: A systematic review and meta-analysis of findings from the gait cycle, muscle activity and dynamic barefoot plantar pressure." Clinical Biomechanics (Bristol, Avon) 28(8): 831-845

Fernando M, R Crowther, PA Lazzarini, K Sangla, M Cunningham and J Golledge (2013), "Is it how they walk? Biomechanics in diabetic peripheral neuropathy: a review of the literature." Journal of Foot & Ankle Research 6(Suppl 1): P4

Fernando ME, RM Seneviratne, M Cunningham, PA Lazzarini, KS Sangla, YM Tan, PG Buttner and J Golledge (2013), "Intensive versus conventional glycaemic control for treating diabetic foot ulcers (Protocol)." Cochrane Database of Systematic Reviews 2013(10)

Fielding DI, F Bashirzadeh, D Deller, A Douglas, R Boots and P Hopkins (2013), "Life-saving closure of a pulmonary cavity by endobronchial valve placement." Am J Respir Crit Care Med 187(10): 1145-1146

Finch E, P Cornwell, E Ward and S McPhail (2013), "Research interest and experience in a speech-language pathology workforce: Factors influencing research engagement." Biomed Central: Health Services Research 13: 144

Fong KM (2013), "Lung cancer." J Thorac Dis 5 Suppl 5: S452-453

Foster SR, ER Porrello, B Purdue, HW Chan, A Voigt, S Frenzel, RD Hannan, KM Moritz, DG Simmons, P Molenaar, E Roura, U Boehm, W Meyerhof and WG Thomas (2013), "Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart." PLoS One 8(5): e64579

Francis DK, PA Lazzarini, TS Ferguson, SD Jen, C Cumberbatch and V Welch (2013), "Education of health professionals for preventing diabetic foot ulceration (Protocol)." Cochrane Database of Systematic Reviews 2013(3)

Francis RL, L Moore, A Bullen, O Tronstad, G Javorsky, M Brown, S McKenzie, D Platts and SS Kuys (2013), "MOBILE-HF: Physiotherapist Supervised Early Mobilisation in Patients with Acute Decompensated Heart Failure." Heart, Lung and Circulation 22(S1): S83

Francis SM, ME Tan, PR Fung, JG Shaw, AB Semmler, M Nataatmadja, RV Bowman, KM Fong and IA Yang (2013), "Peripheral compartment innate immune response to Haemophilus influenzae and Streptococcus pneumoniae in chronic obstructive pulmonary disease patients." Innate Immun 19(4): 428-437

Fraser JF, MS Hussain, C Eskey, T Abruzzo, K Bulsara, J English, K Blackham, HM Do, C Prestigiacomo, MV Jayaraman, A Patsalides, M Kelly, JL Sunshine, P Meyers and Society for NeuroInterventional Surgery (2013), "Reporting standards for endovascular chemotherapy of head, neck and CNS tumors." J Neurointerv Surg 5(5): 396-399

Fukushima S, PJ Tesar, B Pearse, H Jalali, L Sparks, JF Fraser and PG Pohlner (2014), "Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft." J Thorac Cardiovasc Surg 148(1): 65-72 e62

Fung YL, JP Tung, SR Foley, G Simonova, O Thom, A Staib, J Collier, KR Dunster, C Solano, K Shekar, MS Chew and JF Fraser (2013), "Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage." Vox Sang 105(2): 150-158

Godfrey M, P Cornwell, S Eames, T Thomas, S Shand, D Robinson, L O'Brien, E Grant and A Gillen (2013), "Informing the development of a framework to support occupational therapists clinical reasoning processes regarding pre-discharge home visits." Australian Occupational Therapy Journal 60(S1): 139

Goh F, JG Shaw, SM Savarimuthu Francis, A Vaughan, L Morrison, V Relan, HM Marshall, AG Dent, PE O’Hare, A Hsiao, RV Bowman, KM Fong and IA Yang (2013), "Personalising and targeting therapy for COPD – the role of molecular and clinical biomarkers." Expert Rev Respir Med 7(6): 593-605

Gompelmann D, R Eberhardt, A Ernst, P Hopkins, J Egan, F Stanzel, A Valipour, M Wagner, C Witt, KM Baker, MH Gotfried, S Kesten, G Snell and FJ Herth (2013), "The localized inflammatory response to bronchoscopic thermal vapor ablation." Respiration 86(4): 324-331

Goss CH and SC Bell (2012), "Aztreonam for inhalation solution, challenges to drug approval and integration into CF care." J Cyst Fibros

Gregory SD, N Loechel, MJ Pearcy, J Fraser, S Parnis, WE Cohn and D Timms (2013), "Anatomic fitting of total artificial hearts for in vivo evaluation." Artif Organs 37(8): 735-741

Gregory SD, MJ Pearcy, J Fraser and D Timms (2013), "Evaluation of inflow cannulation site for implantation of right-sided rotary ventricular assist device." Artif Organs 37(8): 704-711

Gregory SD, MC Stevens, E Wu, JF Fraser and D Timms (2013), "In vitro evaluation of aortic insufficiency with a rotary left ventricular assist device." Artif Organs 37(9): 802-809


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Gurunathan U (2013), "Perioperative considerations of bilateral total knee replacement: a review." J Clin Anesth 25(3): 232-239

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Hammond NE, AJ Spooner, AG Barnett, A Corley, P Brown and JF Fraser (2013), "The effect of implementing a modified early warning scoring (MEWS) system on the adequacy of vital sign documentation." Aust Crit Care 26(1): 18-22

Haqqani HM and FE Marchlinski (2013), "Improving the resolution of ventricular tachycardia substrate mapping: marrying (ultra)structure and function." J Cardiovasc Electrophysiol 24(4): 427-429

Haqqani HM, JB Morton and JM Kalman (2013), "Channeling post-infarction ventricular tachycardia ablation: "electroanatomy" versus electrophysiology." J Am Coll Cardiol 61(20): 2096-2097

Hayes RA, K Shekar and JF Fraser (2013), "Hyperoxic damage and the need for optimised oxygenation practices." Crit Care 17(4): 441

Hayes RA, K Shekar and JF Fraser (2013), "Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem." Perfusion 28(3): 184-193

Hayward KS, SS Kuys, RN Barker and SG Brauer (2013), "Stroke survivors with severe motor disability can make clinically important improvements during inpatient rehabilitation." International Journal of Stroke 8(S1): 17

Hegarty CP and JE Mikli (2013), "Behavioural disturbance requiring medical referral: A case of anti-N-methyl-D-aspartate receptor encephalitis in the emergency department." Emerg Med Australas 25(1): 87-89

Heller G, VN Babinsky, B Zeigler, M Weinzierl, C Noll, C Altenberger, L Mullauer, G Dekan, Y Grin, G Lang, A End-Pfutzenreuter, I Steiner, S Zehetmayer, B Dome, BM Arns, KM Fong, CM Wright, IA Yang, W Klepetkop, M Posch, CC Zielinski and S Zochbauer-Muller (2013), "Genome-wide CpG island methylation analyses in non-small cell lung cancer patients." Carcinogenesis 34(3): 513-521

Henning MA, R Pinnock, W Hazell and S Hawken (2013), "Professionalism in Medical Education." Education on Medicine Journal 5(3)

Hillier S, D Burstow, D Platts and J Sedgwick (2013), "The Role of Transoesophageal and Serial Echocardiography with a Normal Transthoracic Study And Clinical Suspicion of Staphylococcus aureus Infective Endocarditis." Heart, Lung and Circulation 22: S202

Hillier S, D Roper, M Harten, P Hopkins and D Platts (2013), "Echocardiographic Assessment of Pulmonary Vein Velocities Following Lung Transplantation." Heart, Lung and Circulation 22: S176

Hofmeyr L, P Pohlner and DJ Radford (2013), "Long-term complications following surgical patch closure of multiple muscular ventricular septal defects." Congenit Heart Dis 8(6): 541-549

Holloway JW, Yang IA, Rosenwasser LJ and ST Holgate (2013), The potential of genetics in allergic diseases. World Allergy Organization (WAO) White Book on Allergy. R Pawankar, GW Canonica, ST Holgate and RF Lockey. Milwaukee, World Allergy Organization: 77-82

Houston N, N Stewart, DS Smith, SC Bell, AC Champion and DW Reid (2013), "Sputum neutrophils in cystic fibrosis patients display a reduced respiratory burst." J Cyst Fibros 12(4): 352-362

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Hwang R, F Chuan, R Peters and S Kuys (2013), "Urinary incontinence in people with chronic heart failure. Reply to a letter to the Editor." Heart Lung 42(2): 154-155

Isbister G, C Page, L Calver, F Kinnear (2014), “A safety and efficacy study of a standardised protocol of intramuscular (IM) droperidol for acute behavioral disturbance in the Emergency Department environment.” ACEM QLD Emergency Medicine Autumn Symposium, Brisbane

Impey EJ, CM Wright, V Relan, F Goh, MG Daniels, SM Savarimuthu Francis, EE Duhig, BE Clarke, RV Bowman, KM Fong and I Yang (2013), "Age-related changes in DNA methylation in the lung." Respirology 18, S2 59

Incani A, JC Lee, MJ Nicolae and DL Walters (2014), "Stenting an aortopulmonary conduit with peripheral cardiopulmonary bypass support." Catheter Cardiovasc Interv 83(1): E77-81

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Ischenko M, A Yamada, J Cafaro, V Speranza, M Harten, A Benjamin, D Platts, C Hamilton-Craig, D Burstow and J Chan (2013), "Evaluation of Inter-vendor Consistency and Reproducibility of Left Ventricular Two-dimensional Strain Measurements with Two Different High-end Ultrasound Systems." Heart, Lung and Circulation 22: S177

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Lamanna A, M Brown, D Smith, S McKenzie, D Platts, M Lucas, J Douglas, G Javorsky (2013), "Excessive Daytime Sleepiness and Sleep Disordered Breathing in Stable Heart Failure Patients." Heart, Lung and Circulation 22(Suppl 1): S77

Lamanna A, M Brown, S McKenzie, D Smith, D Platts, M Lucas, J Douglas, G Javorsky (2013), "Poor Health Status and Depression are Associated with Excessive Daytime Sleepiness in Stable Heart Failure Patients." Heart, Lung and Circulation 22(Suppl 1): S206

Lamanna A, S McKenzie, M Brown, D Platts, B Thomson, P Tesar, J Maddicks-Law, J Bancroft, G Javorsky (2013), "Heart Transplant Survival Rates in Patients Requiring a Ventricular Assist Device as a Bridge to Transplant." Heart, Lung and Circulation 22(Suppl 1): S78

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Lawrence P, P Fulbrook and S Miles (2013), Metro North Health Service District Nursing Staff Skin Integrity Knowledge survey 2012, Metro North Pressure Injury Prevention Committee, Queensland Health.

Lazzarini PA, J Geraghty, EM Kinnear, M Butterworth and D Ward (2013), "Research capacity and culture in podiatry: early observations within Queensland Health." Journal of Foot and Ankle Research 6(1): 1-1

Lazzarini PA, J Geraghty, EM Kinnear, M Butterworth and D Ward (2013), "Research skills of Queensland Health podiatrists: how do they rate and are they improving?" Journal of Foot & Ankle Research 6(Suppl 1): P9

Lazzarini PA, JM Gurr, JR Rogers, A Schox and SM Bergin (2013), "Australia’s ‘silent pandemic’ of diabetes complications: where do feet stand in this pandemic?" Journal of Foot & Ankle Research 6(Suppl 1): O25

Lazzarini PA, V Ng, EM Kinnear, MC Kamp, SS Kuys, C Hurst and L Reed (2013), "Is the clinical Queensland High Risk Foot Form valid or reliable for research?" Journal of Foot & Ankle Research 6(Suppl 1): O23

Lazzarini PA, V Ng, PM Rego, SS Kuys and S Jen (2013), "Foot ulcer simulation training (FUST): are podiatrists FUST with long-term clinical confidence?" journal of Foot & Ankle Research 6(Suppl 1): 022


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Lazzarini PA, SR O'Rourke, AW Russell, PH Derhy and MC Kamp (2013), "Queensland diabetic foot hospitalisations (2005-10): In what state is our foot hospital problem? (Abstract)." Journal of Foot & Ankle Research 6(Suppl 1): P8

Lazzarini PA, SR O'Rourke, AW Russell, PH Derhy and MC Kamp (2013), "Reduction in the incidence of diabetes lower extremity amputations in Queensland: 2005-2010 (Abstract)." Journal of Foot and Ankle Research 6(Suppl 1): O20

Lazzarini PA, SR O'Rourke, AW Russell, PH Derhy, MC Kamp, MC d’Emden and EM Kinnear (2013), "Queensland’s high risk foot database: Tracking the length and width of Queensland’s foot ulcers (Abstract)." Journal of Foot & Ankle Research 6(Suppl 1): O21

Lee JC and RA Baer (2013), "Private hospitals and physician education." Intern Med J 43(12): 1354-1355

Lee JC, GF Hartnett and AS Ravi Kumar (2013), "Investigation of incidental bowel FDG uptake." J Gastrointest Surg 17(12): 2182

Lee JC, KM Harvey and FA Khafagi (2013), "Cerebral perfusion (SPECT) studies." Aust Fam Physician 42(3): 119-121

Lee JC and SC McKenzie (2013), "Does cardiac testing before trastuzumab therapy actually make a difference?" Intern Med J 43(5): 610

Lee JC, MJ West and FA Khafagi (2013), "Myocardial perfusion scans." Aust Fam Physician 42(8): 564-567

Leong DP, MX Joseph, A Sinhal and JB Selvanayagam (2013), "The evolving role of cardiac imaging in percutaneous valvular intervention." Heart Lung Circ 22(9): 704-716

Leong S, Marshall H, Bint M, Yang IA, Bowman RV and KM Fong (2013), "Mediastinal abscess after endobronchial ultrasound guided transbronchial needle aspiration: a case report and literature review." J Bronchology Interv Pulmonol. 20(4): 338-341

Leong S, T Shaipanich, S Lam and K Yasufuku (2013), "Diagnostic bronchoscopy - current and future perspectives." J Thorac Dis 5 Suppl 5: S498-510

Love A, P Cornwell and S Whitehouse (2013), "Incidence and predictors of dysphagia following hip fracture surgery in the elderly." Age and Ageing 42(6): 782-785

Love AL, PL Cornwell and SL Whitehouse (2013), "Oropharyngeal dysphagia in an elderly post-operative hip fracture population: a prospective cohort study." Age Ageing 42(6): 782-785

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Luis SA, K Poon, C Luis, A Shukla, N Bett and C Hamilton-Craig (2013), "Massive left atrial thrombus in a patient with rheumatic mitral stenosis and atrial fibrillation while anticoagulated with dabigatran." Circ Cardiovasc Imaging 6(3): 491-492

Luis SA, K Poon, R Shetty, DL Walters and OC Raffel (2013), "Optical coherence tomography of late acquired bare metal stent malapposition: bare metal stent "diverticulosis"." Heart Lung Circ 22(8): 688-689

Luis SA, A Yamada, BK Khandheria, V Speranza, A Benjamin, M Ischenko, DG Platts, CR Hamilton-Craig, L Haseler, D Burstow and J Chan (2014), "Use of three-dimensional speckle-tracking echocardiography for quantitative assessment of global left ventricular function: a comparative study to three-dimensional echocardiography." J Am Soc Echocardiogr 27(3): 285-291

Davison M, F Kinnear and P Fulbrook (2014), “Simulation improves staff confidence and orientation to a new children’s emergency service.” Medical Teacher (in press)

Mahendran N, E Downie, P Ng, SS Kuys and SG Brauer (2013), "The validity and reliability of accelerometers and GPS for the purpose of fee-living community ambulation measurement post stroke." International Journal of Stroke 8(S2): 12

Malkin CJ, J Judd, DP Chew and A Sinhal (2013), "Balloon aortic valvuloplasty to bridge and triage patients in the era of trans-catheter aortic valve implantation." Catheter Cardiovasc Interv 81(2): 358-363

Malone M, JM White, L Taylor, AM Schembri, P Lazzarini, NS Lau and HG Dickson (2013), "Update on the Inaugural Sydney Diabetic Foot Conference 2013." The International Journal Of Lower Extremity Wounds

Marshall HM, RV Bowman, J Crossin, MA Lau, RE Slaughter, J Ayres, LH Passmore, EM Mccaul, SC Leong, DA Courtney, MN Windsor, IA Yang, PV Zimmerman, TJ Hayes, SJ Redmond, SC Lam, MC Tammemagi and K Fong (2013), “The Queensland lung cancer screening study: enhanced population risk stratification increases effectiveness of low dose CT screening for lung cancer.” Respirology 18: 36

Marshall HM, RV Bowman, J Crossin, M Fuentes, R Slaughter, L Passmore, E Mccaul, D Courtney, M Windsor, IA Yang, T Hayes, P Zimmerman, S Redmond, I Smith, BJ Keir and KM Fong (2013), "Queensland Lung Cancer Screening Study: rationale, design and methods." Intern Med J 43(2): 174-182

Marshall HM, RV Bowman, IA Yang, KM Fong and CD Berg (2013), " Screening for lung cancer with low-dose computed tomography: a review of current status." J Thorac Dis 5(S5): S524-S539


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Marshall HM, KM Fong and RV Bowman (2013), "Should we screen for lung cancer in Australia?" Med J Aust 199(5): 585-586

Marshall HM and KM Fong (2013), "Screening for Lung Cancer" Cancer Forum 37(2)

Marshall HM, SC Leong, J Bennett, IA Yang, RV Bowman and KM Fong (2013), "Tomosynthesis for detection and management of pulmonary nodules." Lung Cancer Management 2(1): 5-7

Marshall HM, RV Bowman, J Crossin, MA Lau, RE Slaughter, LH Passmore, EM McCaul, DA Courtney, MN Windsor, IA Yang, IR Smith, BJ Keir, TJ Hayes, SJ Redmond, PV Zimmerman and KM Fong (2013), "Queensland Lung Cancer Screening Study: rationale, design and methods." Intern Med J 43(2): 174-182

Marshall HM, RV Bowman, IA Yang, KM Fong and CD Berg (2013), "Screening for lung cancer with low-dose computed tomography: a review of current status." J Thorac Dis 5 Suppl 5: S524-539

Martin HV, PA Lazzarini, EM. Kinnear, L Munck and J Fraser (2013), "Dying feet in ICU: why might extracorporeal membrane oxygenation machines cause necrotic feet?" Journal of Foot & Ankle Research 6(Suppl 1): O26

Maurice A, J Sherman, N Daley, K Collins, D Burstow, D Platts, J Chan, G Scalia, P Tesar, A Yamada and J Sedgwick (2013), "The Sensitivity and Specificity of Modern-Era 2D/3D Transoesophageal and Transthoracic Echocardiography for Diagnosis of Native and Prosthetic Valve Left-Sided Infective Endocarditis Compared with Surgical Findings." Heart, Lung and Circulation 22: S202-S203

Maybauer MO, S Asmussen, DG Platts, JF Fraser, F Sanfilippo and DM Maybauer (2014), "Transesophageal echocardiography in the management of burn patients." Burns 40(4): 630-635

McClanachan NJ, J Gesch, N Wuthapanich, J Fleming and SS Kuys (2013), "Feasibility of gaming console exercise and its effect on endurance, gait and balance in people with an acquired brain injury." Brain Inj 27(12): 1402-1408

McDonald C, K Colebourne, HM Faddy, R Flower and JF Fraser (2013), "Plasma selenium status in a group of Australian blood donors and fresh blood components." J Trace Elem Med Biol 27(4): 352-354

McDougall CJ, HS Gray, PM Simpson, SL Whitehouse, RW Crawford and WJ Donnelly (2013), "Complications related to therapeutic anticoagulation in total hip arthroplasty." J Arthroplasty 28(1): 187-192

McGuire A, D Anderson and P Fulbrook (2013), "Percieved barriers to healthy lifestyle activities in midlife and older Australian women with type 2 diabetes." Collegian

McInerney-Leo AM, MS Marshall, B Gardiner, PJ Coucke, L Van Laer, BL Loeys, KM Summers, S Symoens, JA West, MJ West, B Paul Wordsworth, A Zankl, PJ Leo, MA Brown and EL Duncan (2013), "Whole exome sequencing is an efficient, sensitive and specific method of mutation detection in osteogenesis imperfecta and Marfan syndrome." Bonekey Rep 2: 456

McKenzie S, D Platts, J Bancroft, J Maddicks-Law, M Brown, B Thomson and G Javorsky "Preoperative Predictors for Length of ICU Admission after Ventricular Assist Device (VAD) Implantation as Bridge to Transplant—A Single Centre Experience." Heart, Lung and Circulation 22: S86

McKenzie SC, M Brown, D Platts, G Javorsky, J Maddicks-Law, M Whitby (2013), "Heart Transplant Workup Medical Imaging and Resulting Radiation Exposure." Journal of Heart and Lung Transplantation 32(4): S206

McKenzie SC, A Goodman, R Mahoney, R Corpus, and MR Brown (2013), "The Economic Savings of Queensland’s Indigenous Cardiac Outreach Program." Heart, Lung and Circulation 22(Suppl 1): S254

Mercer M, K Bootle, G Kewalram, A Attokaran, P Masel, SS Kuys, S Cochrane and M Godfrey (2013), "Community acquired pneumonia changes in functional ability over time." Australian Occupational Therapy Journal 60(S1): 83

Meredith IT, S Verheye, NJ Weissman, P Barragan, D Scott, MV Chavarri, NE West, H Kelbaek, R Whitbourn, DL Walters, J Kubica, L Thuesen, M Masotti, A Banning, I Sjogren, RH Stables, DJ Allocco and KD Dawkins (2013), "Six-month IVUS and two-year clinical outcomes in the EVOLVE FHU trial: a randomised evaluation of a novel bioabsorbable polymer-coated, everolimus-eluting stent." EuroIntervention 9(3): 308-315

Miles S, P Fulbrook, T Nowicki and C Franks (2013), "Decreasing pressure injury prevalence in an Australian general hospital: a 10 year review." Wound Practice and Research 21(4): 148-156

Milne TE, JR Rogers, EM Kinnear, HV Martin, PA Lazzarini, TR Quinton and FM Boyle (2013), "Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot Neuro-Arthropathy: a systematic review." Journal of Foot and Ankle Research 6(1): 30-30

Molenaar P, T Christ, RI Hussain, A Engel, E Berk, KT Gillette, L Chen, A Galindo-Tovar, KA Krobert, U Ravens, FO Levy and AJ Kaumann (2013), "PDE3, but not PDE4, reduces beta(1) - and beta(2)-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients." Br J Pharmacol 169(3): 528-538

Morishima T, BL Ginsel, GG Choy, LJ Wilson, SL Whitehouse and RW Crawford (2014), "Periprosthetic fracture torque for short versus standard cemented hip stems: an experimental in vitro study." J Arthroplasty 29(5): 1067-1071


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Morrison G (2013), "Implementation and evaluation of a patient and family/carer stroke education program." International Journal of Stroke 8(Supplement 2): 9,.

Mullany D (2013), "Benefits of using ultrasound and non-invasive haemodynamic monitoring for critically ill and cardiac surgical patients." Anaesth Intensive Care 41(6): 706-709

Mustaffa Kamal R, E Ward and P Cornwell (2013), "Levels of Awareness, Involvement and Training in Dysphagia Management Among Other Health Professionals in Malaysia." Dysphagieforum 1: 4-14

Naidoo R, MN Windsor and P Goldstraw (2013), "Surgery in 2013 and beyond." J Thorac Dis 5 Suppl 5: S593-606

Nalder E, J Fleming, P Cornwell, MM Foster and C Shields (2013), "Reflections on life: Experiences of individuals with brain injury during the transition from hospital to home." Brain Injury 27(11): 1294-1303

Nestler F, AP Bradley, SJ Wilson and DL Timms (2014), "Modeling of a rotary blood pump." Artif Organs 38(3): 182-190

Ng V, PA Lazzarini, PM Rego and PL Cornwell (2013), "Is foot ulcer simulation training (FUST) really effective? Participants’ supervisors speak out." Journal of Foot & Ankle Research 6(Suppl 1): O24

Nicolae M and DJ Radford (2013). “Common cardiology problems in adolescences.” A clinical handbook in adolescent medicine. K. Steinbeck and M. Kohn. Singapore, World Scientific: 591-604

Nowak A, C Brown, M Millward, J Creaney, M Byrne, B Hughes, et al (2013), “A phase II clinical trial of the vascular disrupting agent BNC105P as second line chemotherapy for advanced pleural mesothelioma.” Lung Cancer 81(3): 422-7

O’Hare PE, J Ayres, R O’Rourke, RE Slaughter, HM Marshall, RV Bowman, KM Fong and I Yang (2013), “Visual coronary artery calcification score on thoracic CT predicts all-cause mortality in patients with COPD.” Respirology 18: 18

Peasey MM, CM Nolan, SSC Kon, JL Canavan, SE Jones, AL Clark and WDC Man (2013), "Pulmonary rehabilitation in idiopathic pulmonary fibrosis: Predictors of adherence and exercise improvement." European Respiratory Journal 42(Suppl 57)

Peel NM and SS Kuys (2013), "Walking activity in older patients in rehabilitation: A prospective study." Journal of Frailty and Aging 2(1): 22-26

Peel NM, SS Kuys and K Klein (2013), "Gait speed as a measure in geriatric assessment in clinical settings: a systematic review." J Gerontol A Biol Sci Med Sci 68(1): 39-46

Peel NM, SS Kuys, A Slater, K Klein, S Paul and RE Hubbard (2013), "Gait speed in nursing home residents: a systematic review." Australasian Journal on Ageing 32(S1): 14

Peeler A, P Fulbrook and S Kildea (2013), "The experiences of parents and nurses of hospitalised infants requiring oxygen therapy for severe bronchoilitis: a phenomenological study." Journal of Child Health

Pizzutto SJ, K Grimwood, P Bauert, KL Schutz, ST Yerkovich, JW Upham and AB Chang (2013), "Bronchoscopy contributes to the clinical management of indigenous children newly diagnosed with bronchiectasis." Pediatr Pulmonol 48(1): 67-73

Plant BJ, CH Goss, WD Plant and SC Bell (2013), "Management of comorbidities in older patients with cystic fibrosis." Lancet Respir Med 1(2): 164-174

Platts D, J Cafaro, A Maurice, K Dunster, S Diab, J Fraser, K Shekar, D Burstow, L Fung and J Chan (2013), "Temporal Changes in Left Ventricular Radial and Circumferential Strain During Venovenous Extra Corporeal Membrane Oxygenation Following Acute Lung Injury in an Ovine Model." Heart, Lung and Circulation 22: S198

Platts D, S Diab, C MacDonald, M Tunbridge, S Chemonges, K Dunster, K Shekar, D Burstow, D Mullany and J Fraser (2013), "The Impact of Continuous Flow From Venovenous Extracorporeal Membrane Oxygenation Cannulae on Tricuspid Valve Geometry and Function." Heart, Lung and Circulation 22: S199

Platts D, A Hilton, S Diab, C MacDonald, M Tunbridge, S Chemonges, K Dunster, K Shekar, D Burstow and J Fraser (2013), "Feasibility of a Novel Echocardiographic Imaging Technique, Intracatheter Echocardiography, to Guide Venovenous Extracorporeal Membrane Oxygenation Cannulae Placement in a Validated Ovine Model." Heart, Lung and Circulation 22: S180

Platts D, B Sim, M Tunbridge, S Diab, K Dunster, K Shekar, D Burstow, M Maybauer, J Chan and J Fraser (2013), "Perflutren Microsphere Contrast Transthoracic Echocardiography Improves Endocardial Definition During Venovenous Extra Corporeal Membrane Oxygenation in a Validated Ovine Model." Heart, Lung and Circulation 22: S190-S191

Platts DG, SA Luis, D Roper, D Burstow, T Call, A Forshaw and R Pascoe (2013), "The safety profile of perflutren microsphere contrast echocardiography during rest and stress imaging: Results from an Australian multicentre cohort." Heart, Lung and Circulation 22(12): 996-1002

Platts DG, M Morsy and D Burstow (2014), "Multi-modality imaging in the assessment of a metastatic cardiac rhabdomyosarcoma presenting with recurrent ventricular tachycardia." Eur Heart J Cardiovasc Imaging 15(3): 306

117Publications | Living & Breathing | Research

Poon K, A Incani, A Small and OC Raffel (2013), "Drug eluting stents trapping intramural hematoma in spontaneous coronary artery dissection and healing pattern at six months: optical coherence tomography findings." Cardiovasc Revasc Med 14(3): 183-186

Poon KK and DL Walters (2013), "MDCT in TAVR for better implant angle and outcomes." JACC Cardiovasc Imaging 6(8): 922

Powell H, CG Garside, JL Simpson, IA Yang, PN Reynolds, SJ Hodge, AL James, J Upham, CR Jenkins, MJ Peters, PG Gibson and AMAZES Study Research Group (2013), "Characteristics of uncontrolled asthma in Australia." Respirology 18, 42

Powers CJ, JA Hirsch, MS Hussain, AT Patsalides, KA Blackham, S Narayanan, SK Lee, JF Fraser, KR Bulsara, CJ Prestigiacomo, CD Gandhi, T Abruzzo, HM Do, PM Meyers, FC Albuquerque, D Frei, ME Kelly, GL Pride, MV Jayaraman, Standards and Guidelines committee of the Society of NeuroInterventional Surgery (2014), "Standards of practice and reporting standards for carotid artery angioplasty and stenting." J Neurointerv Surg 6(2): 87-90

Price EP, DS Sarovich, M Mayo, A Tuanyok, KP Drees, M Kaestli, SM Beckstrom-Sternberg, JS Babic-Sternberg, TJ Kidd, SC Bell, P Keim, T Pearson and BJ Currie (2013), "Within-host evolution of Burkholderia pseudomallei over a twelve-year chronic carriage infection." MBio 4(4)

Pryor L, E Ward, P Cornwell, S O'Connor, M Finnis and M Chapman (2013), "Impact of nasogastric tubes on swallowing physiology in older healthy volunteers: A randomised controlled trial." Dysphagia 28(4): 600-601

Quah JX, L Hofmeyr, H Haqqani, A Clarke, A Rahman, P Pohlner, D Radford and M Nicolae (2013), "The Management of the Older Adult Patient with Anomalous Left Coronary Artery from the Pulmonary Artery Syndrome: A Presentation of Two Cases and Review of the Literature." Congenit Heart Dis

Hakim R, L McCarthy, PJ Masel, RV Bowman, A Burke, S Bazdar, JG Serginson and I Yang (2013), “Personalised care for COPD: the COPD snapshot”. Respirology

Ramsay KA, CA Butler, S Paynter, RS Ware, TJ Kidd, CE Wainwright and SC Bell (2013), "Factors influencing acquisition of Burkholderia cepacia complex organisms in patients with cystic fibrosis." J Clin Microbiol 51(12): 3975-3980

Ranganathan SC, B Skoric, KA Ramsay, R Carzino, AM Gibson, E Hart, J Harrison, SC Bell, TJ Kidd and Australian Respiratory Early Surveillance Team for Cystic Fibrosis (2013), "Geographical differences in first acquisition of Pseudomonas aeruginosa in cystic fibrosis." Ann Am Thorac Soc 10(2): 108-114

Rapchuk IL and P Glover (2013), "Combined use of fascia iliaca block, subarachnoid block and dexmedetomidine sedation for patients having fractured femur surgery." J Anesth 27(1): 149-150

Reid DW and SC Bell (2013), "ICU outcomes in cystic fibrosis following invasive ventilation." Respirology 18(4): 585-586

Reid DW, R Latham, IL Lamont, M Camara and LF Roddam (2013), "Molecular analysis of changes in Pseudomonas aeruginosa load during treatment of a pulmonary exacerbation in cystic fibrosis." J Cyst Fibros 12(6): 688-699

Relan V, L Morrison, K Parsonson, BE Clarke, EE Duhig, MN Windsor, KS Matar, R Naidoo, L Passmore, E McCaul, D Courtney, IA Yang, KM Fong and RV Bowman (2013), "Phenotypes and karyotypes of human malignant mesothelioma cell lines." PLoS ONE 8(3)

Renjel R, S Pandy, E Eeles (2013), “Delirium in medical inpatients: Adverse outcomes.” OA Medical Hypothesis 2013 Apr 30;1(1):4

Rodriguez AD, L Worrall, K Brown, B Grohn, E McKinnon, C Pearson, S van Hees, T Roxbury, P Cornwell, A McDonald, A Angwin, E Cardell, B Davidson and D Copland (2013), "Aphasia LIFT: A Phase I/II trial of an intensive comprehensive therapy program." Aphasiology 27(11): 1339-1361

Roehrer E, E Cummings, P Turner, J Hauser, H Cameron-Tucker, SA Beggs, NA Micallef, C Wainwright, J Cheney, M Jessup, H Saddington, L Ellis, H Walters and DW Reid (2013), "Supporting cystic fibrosis with ICT." Stud Health Technol Inform 183: 137-141

Roper D, SD Hillier, DJ Burstow and D Platts (2014), "Non-tropical endomyocardial fibrosis associated with sarcoidosis." Eur Heart J Cardiovasc Imaging 15(4): 472

Rowland NC, J Breshears and EF Chang (2013), "Neurosurgery and the dawning age of Brain-Machine Interfaces." Surg Neurol Int 4(Suppl 1): S11-14

Russell TG, TC Hoffman, M Nelson, L Thompson and A Vincent (2013), “Internet-based physical assessment of people with Parkinson Disease is accurate and reliable: A pilot study.” Journal of Rehabilitation Research & Development 50(5) 643:650

Safaa AM, LL Du, R Batra and N Essack (2013), "A rare case of adult type ALCAPA syndrome: presentation, diagnosis and management." Heart Lung Circ 22(6): 444-446

Salamonsen RF, V Pellegrino, JF Fraser, KHayes, D Timms, NH Lovell and C Hayward (2013), "Exercise studies in patients with rotary blood pumps: cause, effects, and implications for starling-like control of changes in pump flow." Artif Organs 37(8): 695-703

Samardhi H, DL Walters, C Raffel, S Rateesh, C Harley, D Burstow, P Pohlner and C Aroney (2014), "The long-term outcomes of transcoronary ablation of septal hypertrophy compared to surgical myectomy in patients with symptomatic hypertrophic obstructive cardiomyopathy." Catheter Cardiovasc Interv 83(2): 270-277

118



Savage ML, KK Poon, EM Johnston, OC Raffel, A Incani, J Bryant, S Rashford, M Pincus and DL Walters (2014), "Pre-hospital ambulance notification and initiation of treatment of ST elevation myocardial infarction is associated with significant reduction in door-to-balloon time for primary PCI." Heart Lung Circ 23(5): 435-443

Savarimuthu Francis SM, ME Tan, PR Fung, JG Shaw, ABT Semmler, M Nataatmadja, RV Bowman, KM Fong and IA Yang (2013), "Peripheral compartment innate immune response to Haemophilus influenzae and Streptococcus pneumoniae in chronic obstructive pulmonary disease patients." Innate Immun 19(4): 428-437

Schnitker LM, M Martin-Khan, E Burkett, ERA Beattie, RN Jones, LC Gray and the Research Collaboration for Quality Care of Older Persons: Emergency Care Panel (2014), "Improving Quality of Care of Older People with Cognitive Impairment in Emergency Departments: Structural Quality Indicators." Academic Emergency Medicine

Scott L, J Crilly, W Chaboyer and M Jessup (2013), "Paediatric pain assessment and management in the emergency setting: the impact of a paediatric pain bundle." International Emergency Nursing 21(30): 173-179

Seeto T, SS Kuys, C Budden, E Griffin, H Kajewski and S McPhail (2013), "Feasibility of an interdisciplinary early intervention for patients with low levels of responsiveness following an Acquired Brain Injury." Brain Impairment 14(2): 213-222

Sengupta A and D Platts (2013) "Incidence of Basal Septal Bulge in Echocardiographic Referrals." Heart, Lung and Circulation 22: S57

Shekar K, AR Davies, DV Mullany, R Tiruvoipati and JF Fraser (2013), "To ventilate, oscillate, or cannulate?" J Crit Care 28(5): 655-662

Shekar K, JF Fraser and JA Roberts (2013), "Can optimal drug dosing during ECMO improve outcomes?" Intensive Care Med 39(12): 2237

Shekar K, JA Roberts, S Ghassabian, DV Mullany, SC Wallis, MT Smith and JF Fraser (2013), "Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?" J Antimicrob Chemother 68(3): 726-727

Shekar K, JA Roberts, MT Smith, YL Fung and JF Fraser (2013), "The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation." BMC Anesthesiol 13: 7

Simonova G, JP Tung, JF Fraser, HL Do, A Staib, MS Chew, KR Dunster, KM Glenister, DE Jackson and YL Fung (2014), "A comprehensive ovine model of blood transfusion." Vox Sang 106(2): 153-160

Simpson J, P Gibson, IA Yang, J Upham, A James, P Reynolds and S Hodge (2013), "Altered sputum granzyme B and granzyme B/PI-9 in patients with non-eosinophilic asthma." Respirology (in press)

Simpson JL, PG Gibson, IA Yang, J Upham, A James, PN Reynolds, S Hodge and the AMAZES Study Research Group (2013), "Impaired macrophage phagocytosis in non-eosinophilic asthma." Clinical & Experimental Allergy 43: 29-35

Simpson JL, IA Yang, PN Reynolds, SJ Hodge, AL James, J Upham, C Jenkins, M Peters, PG Gibson and The AMAZES Study (2013), “Alternatives to induced sputum for identifying patients with eosinophilic asthma.” Respirology 18: 43

Sinclair K, ST Yerkovich and DC Chambers (2013), "Mesenchymal stem cells and the lung." Respirology 18(3): 397-411

Sinhal AR and PE Aylward (2013), "New antiplatelet agents and the role of platelet function testing in acute coronary syndromes." Clin Ther 35(8): 1064-1068

Sivagangabalan G, W Chik, S Zaman, W Stafford, J Hayes, R Denman, G Young, P Sanders and P Kovoor (2013), "Antitachycardia pacing for very fast ventricular tachycardia and low-energy shock for ventricular arrhythmias in patients with implantable defibrillators." Am J Cardiol 112(8): 1153-1157

Sivakumar BS, LM McDermott, JJ Bell, CR Pulle, S Jayamaha and MC Ottley (2013), "Dedicated hip fracture service: implementing a novel model of care." ANZ J Surg 83(7-8): 559-563

Smith DJ, GJ Anderson, SC Bell and DW Reid (2014), "Elevated metal concentrations in the CF airway correlate with cellular injury and disease severity." J Cyst Fibros 13(3): 289-295

Smith DJ, GJ Anderson, IL Lamont, P Masel, SC Bell and DW Reid (2013), "Accurate assessment of systemic iron status in cystic fibrosis will avoid the hazards of inappropriate iron supplementation." J Cyst Fibros 12(3): 303-304

Smith DJ, IL Lamont, GJ Anderson and DW Reid (2013), "Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis." Eur Respir J 42(6): 1723-1736

Smith I, I Rapchuk, C Macdonald, B Thomson and B Pearse (2013), "Management of Exsanguination During Laser Lead Extraction." J Cardiothorac Vasc Anesth

Speranza V, A Yamada, J Cafaro, M Ischenko, A Benjamin, M Harten, B Anderson, D Platts, C Hamilton-Craig, D Burstow and J Chan (2013), "Assessment of Inter-observer Reproducibility of Left Ventricular Global Longitudinal Strain between an Expert and Novice Observer." Heart, Lung and Circulation 22: S166

119Publications | Living & Breathing | Research

Spooner AJ, W Chaboyer, A Corley, N Hammond and JF Fraser (2013), "Understanding current intensive care unit nursing handover practices." Int J Nurs Pract 19(2): 214-220

Stanton T, D Holland, L Short, R Leano, B Haluska, D Burstow, J Chan and C Hamilton-Craig (2013), "Reliability of Speckle Strain Echocardiography for the Assessment of Right Ventricular Function." Heart, Lung and Circulation 22: S195

Stevens MC, AP Bradley, SJ Wilson and DG Mason (2013), "Evaluation of a morphological filter in mean cardiac output determination: application to left ventricular assist devices." Med Biol Eng Comput 51(8): 891-899

Stewart G, A Yamada, J Chan, L Haseler, J Kavanagh and S Sabapathy (2013), "Dynamic Low Intensity Exercise Echocardiography for the Assessment of Strain After High Intensity Endurance Exercise." Heart, Lung and Circulation 22: S174

Strange G, E Gabbay, F Kermeen, T Williams, M Carrington, S Stewart and A Keogh (2013), "Time from symptoms to definitive diagnosis of idiopathic pulmonary arterial hypertension: The delay study." Pulm Circ 3(1): 89-94

Subban V, B Bell, OC Raffel, A Small, M Savage, A Incani and DL Walters (2014), "A rare mechanism of very late bare metal stent thrombosis - role of optical coherence imaging in its evaluation and management." Heart Lung Circ 23(2): 190-192

Subban V, A Incani, A Clarke, C Aroney, GM Scalia, JA Crowhurst, OC Raffel and DL Walters (2013), "Conservative management and resolution of a contained rupture of aortic annulus following transcatheter valve replacement." JACC Cardiovasc Interv 6(6): e33-34

Syrmis MW, RJ Moser, TJ Kidd, P Hunt, KA Ramsay, SC Bell, CE Wainwright, K Grimwood, MD Nissen, TP Sloots and DM Whiley (2013), "High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform." J Med Microbiol 62(Pt 5): 734-740

Tjahjadi C, C Hamilton-Craig, F Syed, J Chan, D Burstow and D Platts (2013), "Diagnostic Utility and Economic Impact of Contrast Echocardiography." Heart, Lung and Circulation 22: S172

Toon MH and MR Brown (2013), "Tachycardia of unknown Origin." Med J Aust 199(11): 791

Traykov VB, R Pap, Z Gingl, S Chadaide, HM Haqqani, G Klausz, R Gallardo, T Forster, DJ Callans and L Saghy (2013), "Role of triggering pulmonary veins in the maintenance of sustained paroxysmal atrial fibrillation." Pacing Clin Electrophysiol 36(7): 845-854

Tschabrunn CM, HM Haqqani, JM Cooper, S Dixit, FC Garcia, EP Gerstenfeld, DJ Callans, ES Zado and FE Marchlinski (2013), "Percutaneous epicardial ventricular tachycardia ablation after noncoronary cardiac surgery or pericarditis." Heart Rhythm 10(2): 165-169

Tyack Z, KA Frakes, P Cornwell, SS Kuys, AG Barnett and SM McPhail (2013), "The health outcomes and costs of people attending an interdisciplinary chronic disease service in regional Australia: protocol for a longitudinal cohort investigation." BMC Health Serv Res 13: 410

Walsh J, Z McKeough, N Morris, S TYerkovich, M Wood and J Paratz (2013), "Seasonal variation and living alone are related to pulmonary rehabilitation non-completion." World Journal of Respirology 3(2): 29-37

Walsh JR, DC Chambers, RJ Davis, NR Morris, HE Seale, ST Yerkovich and PM Hopkins (2013), "Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength." Clin Transplant 27(4): E504-511

Walsh JR, ZJ McKeough, NR Morris, AT Chang, ST Yerkovich, HE Seale and JD Paratz (2013), "Metabolic disease and participant age are independent predictors of response to pulmonary rehabilitation." J Cardiopulm Rehabil Prev 33(4): 249-256

Walsh JR, ZJ McKeough, NR Morris and JD Paratz (2013), "Performance-based criteria are used in participant selection for pulmonary rehabilitation programs." Aust Health Rev 37(3): 331-336

Walters DL, A Sinhal, D Baron, S Pasupati, S Thambar, G Yong, N Jepson, R Bhindi, J Bennetts, R Larbalestier, A Clarke, P Brady, H Wolfenden, A James, A El Gamel, P Jansz, DP Chew and Source ANZ investigators (2014), "Initial experience with the balloon expandable Edwards-SAPIEN Transcatheter Heart Valve in Australia and New Zealand: the SOURCE ANZ registry: outcomes at 30 days and one year." Int J Cardiol 170(3): 406-412

Watts RP, O Thom and JF Fraser (2013), "Inflammatory signalling associated with brain dead organ donation: from brain injury to brain stem death and post transplant ischaemia reperfusion injury." J Transplant 2013: 521369

Wiemers P, L Marney, R Muller, M Brandon, P Kuchu, K Kuhlar, C Uchime, D Kang, N White, R Greenup, JF Fraser, S Yadav and R Tam (2014), "Cardiac surgery in Indigenous Australians - how wide is 'the gap'?" Heart Lung Circ 23(3): 265-272

Wijesekera VA and DJ Radford (2013), "Hypertrophic osteoarthropathy in Eisenmenger syndrome." Congenit Heart Dis 8(3): E65-69

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Wood ME, DJ Smith DW Reid, PJ Masel, MW France and SC Bell (2013), "Ivacaftor in severe cystic fibrosis lung disease and a G551D mutation." Respirology Case Reports 1(3): 52-54

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Worthley SG, CP Tsioufis, MI Worthley, A Sinhal, DP Chew, IT Meredith, Y Malaiapan and V Papademetriou (2013). "Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial." Eur Heart J 34(28): 2132-2140

Wright CM, SM Savarimuthu Francis, KB Sriram, MS Stark, NK Hayward, IA Yang, RV Bowman and K Fong (2013), Distinct profiles for lung cancer and its major subtypes, Respirology 18: 23

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121Journal Editorial Positions | Living & Breathing | Research

PROFESSOR DARREN WALTERS

Associate Editor, International Journal

Cardiology; Editorial Board, Heart

Lung and Circulation

ASSOCIATE PROFESSOR CHRISTIAN HAMILTON-CRAIG

Circulation:Cardiovascular Imaging;

JACC:Cardiovascular Imaging;

Journal of the American College

of Cardiology (JACC); European

Heart Journal; European Heart

Journal Cardiovascular Imaging;

Journal of Cardiovascular Computed

Tomography; Internal Medicine

Journal; Heart Lung & Circulation;

Editorial Board Member, World Journal

of Cardiology

PROFESSOR JOHN FRASER

Editor, Intensive Care Medicine

experimental (ICMx); Editorial Board

Member, Burns; Editorial Board

Member, Current Anaesthesia and

Critical Care

ASSOCIATE PROFESSOR PETER MOLENAAR

Associate Editor, Pharmacology

& Therapeutics; Editor, Naunyn-

Schmiedeberg’s Archives of

Pharmacology

PROFESSOR SCOTT BELL

Editor-in-Chief, Journal of Cystic

Fibrosis

ASSOCIATE PROFESSOR DANIEL CHAMBERS

Editorial Board Member, European

Respiratory Journal.

PROFESSOR KWUN FONG

Co-Editor, Lung Cancer Cochrane

group; Associate-Editor, APSR

Newsletter; Deputy Editor-in-Chief,

Journal of Thoracic Disease

ASSOCIATE PROFESSOR IAN YANG

Deputy Editor, Respirology; Editorial

Board Member, Respirology; Senior

Associate Editor, Clinical and

Experimental Allergy; Editor, Cochrane

Airways Group

PROFESSOR ROSS CRAWFORD

Editor, Journal of Arthroplasty

DR BILL DONNELLY

Editor, Journal of Arthroplasty

DR PETREA CORNWELL

Editorial Committee, Brain Impairment

PETER LAZZARINI

Guest Editor, Journal of Foot and

Ankle Research

PROFESSOR PAUL FULBROOK

is the editor for one peer-reviewed

journal, and on the editorial board of

another.

Journal Editorial Positions


122

Keeping abreast of emergency

medicine research in a busy clinical

environment can be a tough gig.

Which is why having a dedicated non-

medical medical researcher on the

team is a good idea.

Cue Dr Mike Watson, new research

coordinator for The Prince Charles

Hospital’s emergency medicine

services.

Mike’s research career has been global,

from working on Duchenne muscular

dystrophy in the UK, to teaching at

a medical school in the Caribbean

for three years, and chronic kidney

disease trials in Brisbane.

Mike decided he wanted something

in a similar but more varied field and

a year ago started in the Emergency

Department.

‘I’m a scientist by trade. I’ve done

the science in terms of pre-clinical

research,’ he says. ‘But after the

Caribbean, I had to decide between

going back to academia or something

different. I chose something different,

hospitals.’

Mike has a science degree and

postgraduate training in medical

research and physiology, as well

as some workplace training and

assessment. His role in the ED is

to promote the opportunities for

research to both staff and patients.

‘You can’t make people do research,’

he says. ‘But create a culture of

research and then people start

thinking about research and wanting

to get involved.’

The department has been successful in

a short period of time, being invited to

participate in an international multisite

study.

Mike’s role is to find the balance

between homegrown research

projects and collaborating with larger

centres around the world.

‘An important part of research is

showing our peers we can work with

them and produce results,’ he says.

‘I’m focused on building the research

culture and infrastructure, and

securing grant money.’

One of the challenges is working in

an environment where there is a huge

number of staff who might all be

different each day and balancing the

research interests against the reality of

a busy department.

Mike tries to keep each study to a

discrete patient group so people aren’t

being asked to participate in multiple

research projects during their short

time in Emergency.

‘I’m also trying to get all the staff to

the point where getting involved in

research is easy and they aren’t scared

to enrol someone to a study,’ he says.

‘But it’s an Emergency Department.

We might see someone for only two

hours and then they go home or move

onto another area, so we don’t want to

overcomplicate things by overlapping

projects.’

Mike Watson

Living & Breathing | Research | Mike Watson

Cover image: Research Scientist Luke Samson, Queensland Lung Transplant Service.

The Prince Charles Hospital

627 Rode Rd Chermside

Queensland 4032 Australia

Phone: +61 (0)7 3139 4000

http://www.health.qld.gov.au/tpch/


627 Rode Rd Chermside

Queensland 4032 Australia

Phone: +61 (0)7 3139 4636

www.tpchfoundation.org.au

© The Prince Charles Hospital and Foundation

tpch research report 2014

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